CN1130089A - Mini blood purifier - Google Patents
Mini blood purifier Download PDFInfo
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- CN1130089A CN1130089A CN 95110952 CN95110952A CN1130089A CN 1130089 A CN1130089 A CN 1130089A CN 95110952 CN95110952 CN 95110952 CN 95110952 A CN95110952 A CN 95110952A CN 1130089 A CN1130089 A CN 1130089A
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- blood
- polyester fiber
- blood purifier
- mini
- purifier
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Abstract
This invention relates to a miniature blood purifier which has a purifying tube capable of connecting with blood conveying tubing and there is air-exhaust tube on top end of purifying tube in which polyestr fibre filler layer is packed. The said polyester fibre after being treated with acidic or alkaline ionic solution or NaCl solution, is individually packed or mix-packed in layers. In the proces of blood passing through the purifier, the blood cells are statically rubbed with various layers of polyestr fibre, and actions of ion-exchange, adsorption and filtration, and static oxygen-charging are produced so as to make metabolic product removed, CO2 discharged, partial pressure dropped, O2 content increased, and oxygen partial pressure and saturation raised in the blood.
Description
The present invention relates to a kind of mini blood purifier, belong to medical apparatus and instruments.
Usually, the blood of blood transfusion usefulness is from blood bank, and blood bank adopts anticoagulant for storage of whole blood (preserving liquid as ACD or CPD) that blood is preserved under existing state, and storage life was generally 21-35 days.Because the blood of survival is still keeping most physiological functions, in the storage life, the metabolic process of its cell is proceeded, thereby metabolite constantly increases.This metabolite comprises harmful blood ammonia, microgranule and CO such as non-protein nitrogen, excessive free hemoglobin, sodium, potassium ion
2Along with the prolongation of holding time, CO in the blood
2Dividing potential drop increases, O
2Divide drops, influence blood quality.In addition, some acid (alkali) toxic disorder can cause body inner blood cell physiological function to be destroyed, and makes to produce a large amount of harmful substances in the blood, and threat to life need be made hemodialysis, to remove harmful substance in the blood; And for example cerebrovascular ischemia disease, acute infectious diseases etc. need carry out the blood oxygenation treatment.Below all need expensive instrument and equipment, the treatment complicated operation, the medical expense height, general patient is difficult to bear.
The purpose of this invention is to provide a kind of simple mini blood purifier,, remove metabolite, reduce CO so that the blood of input human body and the above-mentioned patient's of taking a disease body inner blood are carried out purified treatment
2, increase O
2Content.
The present invention have one can with the anastomosing depurator of Blood transfusion tubeline, pipe upper end is provided with exhaustor, and the polyester fiber packed layer is housed in the pipe.When blood when layer of polyester fiber is passed through, the part metabolite is adsorbed, removes by filter by fiber, blood cell also produces ion exchange and static friction with polyester fiber simultaneously, further remove the part metabolite and produce nascent oxygen, make oxygen content increase in the blood, partial pressure of oxygen and oxygen saturation improve, CO
2Get rid of from exhaustor.According to the different demands of patient to blood, the polyester fiber in the pipe can pass through different acid-alkali treatment, and when for example being used for alkalotic patient, what pack in the pipe is acid polyester fiber through the acidic ionic liquid processing; When being used for acidosic patient, the basic polyester fiber that can pack into and handle with alkali ion liquid can be with undressed or with the neutral polyester fiber of NaCl solution-treated for general blood transfusion patient.For the occasion that blood purification is had relatively high expectations, can adopt the form that is followed successively by acidity, alkalescence, neutral polyester fiber layering filling from top to bottom.Acid polyester fiber positively charged, the adsorbable blood neutral and alkali metabolite of removing, simultaneously because the cell membrane of positively charged and the electrostatic interaction that the acid fiber same sex is repelled each other produce a large amount of nascent oxygens, so acid fiber layer oxidation effect is the most remarkable.In like manner, basic polyester fabric strip negative electricity, the acidic metabolite in the blood is removed in main absorption, and neutral layer of polyester fiber is mainly adsorbed and is removed neutral metabolite.It is better that the comprehensive purifying effect is loaded in three's layering.Above polyester fiber also can replace with the fabric of polyester fiber.
In sum, depurator of the present invention is simple in structure, and volume is little, only need insert in the Blood transfusion tubeline during use, need not complex operations.This device can be removed waste metabolite in blood effectively, reduces CO
2Dividing potential drop.Utilize static oxygenation principle, make the O of blood
2Dividing potential drop and O
2Saturation rises significantly, reaches the raising blood quality, avoids the therapeutic purposes of transfusion reaction.Not only can be used in the blood transfusion process purified treatment to blood, also can replace expensive hemodialysis apparatus and blood quantization therapeutic instrument that patients' such as some acid (alkali) poisoning and cerebrovascular ischemia body inner blood is purified, operation is simple, reduces medical expense greatly.The purification pipe of this depurator can adopt medical plastic, and manufacturing process is simple, and price is low, can disposablely use, and avoids cross infection.
Below in conjunction with description of drawings structure embodiment of the present invention.
Fig. 1 is this mini blood purifier example structure sketch map.
Fig. 2 is the annexation sketch map of this mini blood purifier in Blood transfusion tubeline.
As shown in Figure 1, this depurator has a plastics purification pipe 3, and there is import 1 upper end of purification pipe, and there is outlet 8 lower end, and outlet is provided with adjustable clamp 7, and exhaustor 2 is located at the upper end of purification pipe.Three strata ester fibers are housed in the purification pipe, and ground floor is acid layer of polyester fiber 4, and the second layer is that the basic polyester fibrous layer is neutral layer of polyester fiber 6 for 5, the three layers.More than three strata ester fiber layers adopted acidic ionic liquid, alkali ion liquid, NaCl solution soaking respectively 24 hours, then with double distilled water repeatedly the rinsing dehydration dry to handle and form.
The annexation of this mini blood purifier on Blood transfusion tubeline seen Fig. 2, among Fig. 2, depurator 3 upper ends be provided with two filters of getting liquid needle tubing 9 10 and connect, lower end and the filter 10 that is connected to injection needle 11 ' be connected, blood is gone into filter 10 by needle tubing 9 and is removed solid particle impurity in the blood, go into this miniature depurator 3, remove metabolite, discharge CO from exhaustor 2
2, make blood purification and oxygenation, then from lower end outlet through filter 10 ' remove small amount of fibers impurity, by injection needle 11 input human veins.
The result of use example of this mini blood purifier is as follows:
Extract human vein blood sample 1 and sample 2 each 200ml, wherein sample 2 passes through with per minute 80 drip speed through depurator of the present invention, sample 2 blood after test purifies respectively and the O without sample 1 blood that purifies
2, CO
2Dividing potential drop, pH value, glucose (GLU), O
2The content of saturation, and observe the blood color, two groups of blood testing data contrast as following table:
PO
2MmHg PCO
2MmHg pH value GLUmg/de O
2The dark red sample of saturation % color and luster sample 1 62.3 229.8 6.561 19.7 30.6 2 138.6 161.8 6.683 19.8 95.3 is scarlet
From last table as seen, after this depurator was handled, partial pressure of oxygen and oxygen saturation in the blood obviously increased CO
2Dividing potential drop obviously descends, and pH value improves in addition, and blood is more drawn close to neutrality.Glucose content slightly increases, and illustrates that the lactic acid metabolism thing reduces.The blood color and luster becomes cerise by kermesinus, more near arterial blood.Blood quality improves.
The used polyester fiber of present embodiment is the hyperfine polyester fiber of 0.5DPF.
Claims (5)
1, mini blood purifier, it is characterized in that having one can with the anastomosing depurator of Blood transfusion tubeline, pipe upper end is provided with exhaustor, and the polyester fiber packed layer is housed in the pipe.
2, mini blood purifier according to claim 1, what it is characterized in that packing in the said purification pipe is the acid polyester fiber packed layer of handling through acidic ionic liquid.
3, mini blood purifier according to claim 1, what it is characterized in that packing in the said depurator is the basic polyester fiber filled layer of handling through alkali ion liquid.
4, mini blood purifier according to claim 1, what it is characterized in that packing in the said purification pipe is neutral polyester fiber packed layer through the NaCl solution-treated.
5, mini blood purifier according to claim 1 is characterized in that in the said purification pipe it being the packed layer acid, alkaline, that neutral polyester fiber layering loads in mixture from top to bottom successively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95110952 CN1130089A (en) | 1995-02-28 | 1995-02-28 | Mini blood purifier |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95110952 CN1130089A (en) | 1995-02-28 | 1995-02-28 | Mini blood purifier |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1130089A true CN1130089A (en) | 1996-09-04 |
Family
ID=5078278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 95110952 Pending CN1130089A (en) | 1995-02-28 | 1995-02-28 | Mini blood purifier |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1130089A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1298397C (en) * | 1998-11-09 | 2007-02-07 | 旭化成医疗株式会社 | Blood purifying apparatus |
| CN1988926B (en) * | 2004-07-23 | 2010-05-05 | 株式会社钟化 | Direct hemoperfusion adsorber packed with adsorbent having water insoluble microparticle removed therefrom, and method of obtaining direct hemoperfusion adsorbent having water insoluble microparticle |
| CN102973994A (en) * | 2012-12-10 | 2013-03-20 | 中国人民解放军第三军医大学第二附属医院 | Functional blood transfusion apparatus |
-
1995
- 1995-02-28 CN CN 95110952 patent/CN1130089A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1298397C (en) * | 1998-11-09 | 2007-02-07 | 旭化成医疗株式会社 | Blood purifying apparatus |
| CN1988926B (en) * | 2004-07-23 | 2010-05-05 | 株式会社钟化 | Direct hemoperfusion adsorber packed with adsorbent having water insoluble microparticle removed therefrom, and method of obtaining direct hemoperfusion adsorbent having water insoluble microparticle |
| CN102973994A (en) * | 2012-12-10 | 2013-03-20 | 中国人民解放军第三军医大学第二附属医院 | Functional blood transfusion apparatus |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |