CN112972708A - Palladium-103 and iodine-125 composite sealed seed source, source core and source core preparation method - Google Patents
Palladium-103 and iodine-125 composite sealed seed source, source core and source core preparation method Download PDFInfo
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- CN112972708A CN112972708A CN202110199136.XA CN202110199136A CN112972708A CN 112972708 A CN112972708 A CN 112972708A CN 202110199136 A CN202110199136 A CN 202110199136A CN 112972708 A CN112972708 A CN 112972708A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
- A61K51/1255—Granulates, agglomerates, microspheres
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
Abstract
A compound sealed seed source of palladium-103 and iodine-125, a source core and a preparation method of the source core. The source core comprises a carrier and a radioisotope thin film covering the carrier, wherein the carrier is made of SiO2The radioactive isotope film contains103Pd and125I. the preparation method of the source core comprises the following steps: step 1) preparation of the carrier: adding proper amount of SiO2Uniformly mixing the powder and water, blending into a viscous material, and sequentially performing extrusion treatment, baking treatment, cutting treatment and polishing treatment on the viscous material to obtain a carrier with a fixed shape; step 2)103Pd and125and I, deposition: cleaning the cleanedThe carrier and a proper amount of stable iodine are put together into the container103Pd element and125heating the mixed solution of the element I to a proper temperature, oscillating at a certain rotating speed for a proper time to cover a layer on the surface of the carrier103Pd and125radioisotope thin film of I.
Description
Technical Field
The invention relates to the technical field of doctor preparations containing radioactive substances, in particular to a palladium-103 and iodine-125 composite sealed seed source, a source core and a source core preparation method.
Background
The tissue implantation treatment is to implant radioactive seeds into tumor tissue, kill tumor cells by using the rays emitted by the seed source core, and achieve the purposes of treating tumors and relieving diseases. The tissue-to-tissue implantation therapy has been used for the treatment of various solid tumors, such as prostate cancer, breast cancer, liver cancer, lung cancer, brain cancer, ovarian cancer and the like, and achieves the same or better treatment effect as surgical operation and external radiotherapy. The tissue implantation treatment includes temporary implantation and permanent implantation, the temporary implantation refers to implanting radioactive seeds into tumor parts, and the radioactive seeds are taken out after a period of treatment; whereas permanent implantation refers to implantation of radioactive seeds into the tumor site without removal. The nuclides commonly used are192Ir，198Au，169Yb，103Pd and125i, etc., wherein103Pd and125i for permanent implantation.
The half-life of the iodine-125 is 59.6 days, the average energy of gamma rays is 28keV, the initial dose rate is 9cGy/h, and the iodine-125 is suitable for treating tumors with good differentiation and slow growth; the half-life of the palladium-103 is 16.96 days, the average energy of gamma rays is 23keV, the initial dose rate is 20cGy/h, and the palladium-103 is suitable for treating tumors with poor differentiation and rapid proliferation. The curative effect of iodine-125 and palladium-103 in treating solid tumors such as prostate cancer is extensively reported in many literatures, for example, Linget compares the curative effects of iodine-125 and palladium-103 on the basis of theoretical radiobiology by using a linear quaternary model, and the conclusion is that: on the basis of clinical application dosage, iodine-125 is superior to iodine-125 in treating tumor with slow proliferation, while palladium-103 has better effect in killing tumor cells with rapid proliferation than iodine-125. Also as shown by the animal experimental study of nagetal: palladium-103 is more effective in treating poorly differentiated carcinomas. Thus, based on the above and other findings, iodine-125 is often used to treat early stage tumors, while palladium-103 is often used to treat intermediate and late stage tumors.
The iodine-125 sealed seed source for treatment is prepared by fixing radioactive iodine-125 on silver rod and sealing in titanium or titanium alloy tube. The method of fixing radioactive iodine-125 to a silver rod generally employs an electroplating method and a chemisorption method. The electroplating method has complex process and high requirements on instruments and equipment,long production period and the like, and is difficult to popularize and apply. In contrast, the chemical adsorption method has simple process and equipment and short production period, and is easy to be applied to large-scale production. For example, U.S. Pat. No. 4,416,55 discloses a chemical adsorption method in which a silver rod is treated with a mixture of sodium chlorite and 6mol/L hydrochloric acid for 1.5 hours to oxidize and chlorinate the surface of the silver rod, thereby obtaining a silver rod with a surface covered with a silver chloride precipitate; then mixing it with iodine125I]The sodium chloride solution is subjected to ion exchange reaction for 18 hours under the condition of pH 10, so that the silver chloride precipitate is converted into iodine125I]And (4) silver dissolving and precipitating. In the method, sodium chlorite is not a conventional reagent and is difficult to purchase in the market; and a large amount of chlorine with pungent smell is generated in the reaction process, thereby polluting the environment.
The therapeutic palladium-103 sealed seed source is prepared by fixing radioactive palladium-103 on a silver rod and welding and sealing the silver rod in a titanium or titanium alloy tube. The method of fixing the radioactive palladium-103 to the silver rod generally employs an electroplating method and an electroless plating method. The electroplating method has complex process, high requirements on instruments and equipment, long production period and difficulty in large-scale production. The chemical plating method has simple process and equipment, short production period and easy popularization and application. For example, chinese patent ZL01105243.0 discloses an electroless plating method, which uses palladium chloride, ammonium chloride, ammonia and sodium hypophosphite as main plating solution components, adjusts PH to 10, and performs electroless plating at 35 ℃ for 1 hour to cover the surface of a silver rod with a layer of palladium-103. The silver rod with the surface covered with palladium-103 obtained in the method is difficult to continuously adsorb iodine-125 on the silver rod, and only a palladium-103 seed source can be prepared.
The current research is to implant single nuclide seed source into tumor for treatment. In fact, the two radioactive seed sources of iodine-125 and palladium-103 can be used in combination. The half-life of palladium-103 is 16.96 days, and 50% of the released dose is only 8.5 days, which becomes a 'first line' for attacking tumor cells; iodine-125 has a half-life of 59.6 days, and it takes 30 days to release 50% of the dose, just becoming the "second echelon" behind palladium-103. The assumption based on the radiobiological effect is also because the palladium-103 is suitable for poorly differentiated and rapidly proliferating tumor cells, while the iodine-125 is suitable for well differentiated and slowly dividing tumor cells, and the combination of the two can more comprehensively attack the tumor cellsTumor cells are targeted. For example, Chen et al have suggested that mixed implantation of palladium-103 seed source while using iodine-125 seed source for clinical survival will increase the killing power on tumor cells; on the other hand, if the palladium-103 seed source is implanted in combination with the iodine-125 seed source in the clinical survival dose for treating the tumor, the so-called cold spots of the radiobiology (namely, the repair increase of the cell survival or sub-lethal cells in the range) are generated at the main part of the dose distribution of the iodine-125 seed source, and the effect of the cold spots is particularly obvious for the tumor with rapid growth. However, there is a certain difficulty in simultaneously plating palladium-103 and iodine-125 on a silver rod support, and if palladium-103 and iodine-125 are simultaneously deposited on a silver rod support, because the two species have very different chemical properties, the deposition of palladium-103 requires the use of a reducing agent, while the deposition of iodine-125 requires an oxidizing agent, and the two species cannot be simultaneously present in the same solution; if palladium-103 is first plated on the carrier, it is difficult to deposit iodine-125 thereon due to the chemical stability of palladium; if iodine-125 is first plated, the iodine-125 is deposited in the form of AgI due to the presence of NH during electroless palladium plating4OH, which results in a large loss of AgI.
Disclosure of Invention
The invention aims to solve the technical problem of providing a palladium-103 and iodine-125 composite sealed seed source, a source core and a source core preparation method.
In order to solve the technical problems, the invention provides the following technical scheme:
in one aspect, the invention provides a source core of a composite sealed seed source of palladium-103 and iodine-125, the source core comprising a carrier and a radioisotope thin film coated on the carrier, wherein the carrier is made of SiO2The radioactive isotope film contains103Pd and125I. the support surface has a plurality of microscopic pores.
Correspondingly, the invention also provides a preparation method of the source core of the composite sealed seed source of palladium-103 and iodine-125, which comprises the following steps:
step 1) preparation of the carrier: adding proper amount of SiO2Mixing the powder with waterMixing, blending into a viscous material, and sequentially performing extrusion treatment, baking treatment, cutting treatment and polishing treatment on the viscous material to obtain a carrier with a fixed shape;
step 2)103Pd and125and I, deposition: putting the cleaned carrier and a proper amount of stable iodine into a container103Pd element and125heating the mixed solution of the element I to a proper temperature, oscillating at a certain rotating speed for a proper time to cover a layer on the surface of the carrier103Pd and125radioisotope thin film of I.
Preferably, in the step 1), the process of sequentially extruding the viscous material includes:
preparing a mould with a forming cavity therein, wherein the forming cavity is a cylindrical cavity;
and pouring the viscous material into a forming cavity of the mold, and then injecting gas into the forming cavity to enable the gas pressure value in the forming cavity to reach 15-20 atmospheric pressures, so that the viscous material is extruded and molded to obtain a strip-shaped body.
Preferably, in the step 1), the baking process includes: and taking out the strip-shaped body, and putting the strip-shaped body into an oven with the temperature of 200-800 ℃ for high-temperature baking for 1.5-2.0 hours.
Preferably, in the step 2), the mixed solution is prepared from103PdCl solution,125ICl2The solution is mixed with water.
Preferably, in the step 2), the temperature of the mixed solution is heated to 30-70 ℃.
Preferably, in the step 2), the rotating speed is 40-500 r/min.
Preferably, in the step 2), the reaction time is 20-40 min.
In another aspect, the invention also provides a palladium-103 and iodine-125 composite sealing seed source, which is prepared by welding the source core of the palladium-103 and iodine-125 composite sealing seed source in a titanium tube or a titanium alloy tube.
The technical scheme of the invention can at least achieve the following beneficial effects:
1. the radioactive isotope film on the surface of the source core simultaneously contains103Pd and125i, whereby, at the tumor site, only the implantation of a composite sealed seed source containing the source core is required103Pd and125the dose distribution of the two nuclides I achieves a satisfactory effect, so that the characteristics of the two nuclides are more fully utilized, the advantages and the disadvantages are made up, the defect of mixed implantation in the prior art is overcome, the maximum killing effect is obtained, and a better treatment effect is obtained;
2. only one step, namely the step 2) can be used103Pd and125i is simultaneously fixed to SiO2The formed carrier with micropores on the surface has short reaction time, simple operation and easy large-scale production.
Detailed Description
The invention provides a source core of a palladium-103 and iodine-125 composite sealed seed source, which comprises a carrier and a radioisotope thin film covering the carrier, and most importantly, the carrier is made of SiO2The radioactive isotope film contains103Pd and125I. here, the surface of the support has a plurality of microscopically visible pores, which makes the support more convenient103Pd and125and I, deposition and adsorption. The support is understood to be a porous glass-like body, the surface of which is rough but only visible under a microscope.
The invention also provides a preparation method of the source core of the composite sealed seed source of palladium-103 and iodine-125, which comprises the steps 1) and 2).
Step 1), preparation of the carrier: adding proper amount of SiO2Uniformly mixing the powder and water to prepare a viscous material; preparing a die with a forming cavity, wherein the forming cavity is a cylindrical cavity with the inner diameter; pouring the viscous material into a forming cavity of the mold, and then injecting gas into the forming cavity to enable the gas pressure value in the forming cavity to reach 15-20 atmospheric pressures, so that the viscous material is extrudedPressing and shaping to obtain a strip-shaped body; taking the strip-shaped body out of the mold, and placing the strip-shaped body into an oven at the temperature of 200-800 ℃ for high-temperature baking for 1.5-2.0 hours; then taking out the strip-shaped body and cutting the strip-shaped body into a rod-shaped body with the diameter of 0.5-1 mm and the length of 1.0-10.0 mm; the rod was lightly sanded to ensure the rod was burr free, resulting in the carrier.
Step 2) of performing a step of performing a,103pd and125and I, deposition: washing the carrier with concentrated hydrochloric acid several times, and placing the washed carrier and proper amount of stable iodine into the carrier103PdCl solution,125ICl2Heating the mixed solution formed by mixing the solution and water to 30-70 ℃, and adding a proper amount of concentrated NH3·H2Adjusting the pH value of the mixed solution to about 10, and oscillating and reacting at the rotating speed of 40-500 r/min for 20-40 min to cover a layer on the surface of the carrier103Pd and125a radioisotope thin film of I; and then taking out the carrier, discarding the supernatant, cleaning the surface of the carrier by using water and acetone, and airing to obtain the source core of the palladium-103 and iodine-125 composite sealed seed source.
Through the detection, the method finds that,103pd and125the deposition of I is far more than 95%, and the self-shielding rate of the carrier is 10-12%.
It should be noted that, in step 2), the rotation speed should not be too high, because too high rotation speed is likely to cause collision between the source cores, resulting in poor deposition effect.
The invention also provides a compound sealing seed source of palladium-103 and iodine-125, which is prepared by welding the source core of the compound sealing seed source of palladium-103 and iodine-125 in a titanium tube or a titanium alloy tube.
In order to facilitate an understanding of the invention, a more complete description of the invention follows. The invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
Example one
This example provides a source core of a palladium-103 and iodine-125 composite sealed seed source, which comprises a carrier and a radioisotope thin film covering the carrier, most importantly, the carrier is made of SiO2The radioactive isotope film contains103Pd and125I. here, the support surface has a plurality of microscopic micropores.
This example also provides a method of preparing a source core of a composite encapsulated seed source of palladium-103 and iodine-125 as described above, the method comprising steps 1) and 2).
Step 1), preparation of the carrier: adding proper amount of SiO2Uniformly mixing the powder and water to prepare a viscous material; preparing a die with a forming cavity, wherein the forming cavity is a cylindrical cavity with the inner diameter; pouring the viscous material into a forming cavity of the mold, and then injecting gas into the forming cavity to enable the gas pressure value in the forming cavity to reach 15 atmospheric pressures, so that the viscous material is extruded and molded to obtain a strip-shaped body; taking the strip-shaped body out of the die, and placing the strip-shaped body into an oven at 200 ℃ for high-temperature baking for 2.0 hours; then taking out the strip-shaped body and cutting the strip-shaped body into a rod-shaped body with the diameter of 0.5mm and the length of 1.0 mm; the rod was lightly sanded to ensure the rod was burr free, resulting in the carrier.
Step 2) of performing a step of performing a,103pd and125and I, deposition: washing the carrier with concentrated hydrochloric acid for three times, taking 50g of the washed carrier with 51g of stable iodine, and putting the carrier and 51g of stable iodine into a reactor of 200ml103PdCl solution (radioactive dose 50mci),125ICl2Mixing the solution (radioactive dose 100mci) with water, heating to 30 deg.C, adding appropriate amount of concentrated NH3·H2Adjusting the pH value of the mixed solution to about 10, and oscillating and reacting at the rotating speed of 40 r/min for 40min to ensure that the surface of the carrier is smoothCovering with a layer103Pd and125a radioisotope thin film of I; then taking out the carrier, discarding the supernatant, and cleaning the surface of the carrier by water and acetone to obtain the source core.
Through the detection, the method finds that,103pd and125the deposition of I is far more than 95%, and the self-shielding rate of the carrier is 10-12%.
The embodiment also provides a palladium-103 and iodine-125 composite sealing seed source, which is prepared by welding the source core of the palladium-103 and iodine-125 composite sealing seed source in a titanium tube or a titanium alloy tube by adopting a laser welding sealing method.
Example two
This example provides a source core of a palladium-103 and iodine-125 composite sealed seed source, which comprises a carrier and a radioisotope thin film covering the carrier, most importantly, the carrier is made of SiO2The radioactive isotope film contains103Pd and125I. here, the support surface has a plurality of microscopic micropores.
This example also provides a method of preparing a source core of a composite encapsulated seed source of palladium-103 and iodine-125 as described above, the method comprising steps 1) and 2).
Step 1), preparation of the carrier: adding proper amount of SiO2Uniformly mixing the powder and water to prepare a viscous material; preparing a die with a forming cavity, wherein the forming cavity is a cylindrical cavity with the inner diameter; pouring the viscous material into a forming cavity of the mold, and then injecting gas into the forming cavity to enable the gas pressure value in the forming cavity to reach 18 atmospheric pressures, so that the viscous material is extruded and molded to obtain a strip-shaped body; taking the strip-shaped body out of the die, and baking the strip-shaped body in an oven at 600 ℃ for 1.8 hours at high temperature; then taking out the strip-shaped body and cutting the strip-shaped body into a rod-shaped body with the diameter of 1.0mm and the length of 3.0 mm; the rod was lightly sanded to ensure the rod was burr free, resulting in the carrier.
Step 2) of performing a step of performing a,103pd and125and I, deposition: with strong saltWashing the carrier with acid for three times, taking 50g of the washed carrier with 51g of stable iodine and putting the carrier and 51g of stable iodine into a 200ml container103PdCl solution (radioactive dose 50mci),125ICl2Mixing the solution (radioactive dose 100mci) with water, heating to 50 deg.C, adding appropriate amount of concentrated NH3·H2Adjusting the pH value of the mixed solution to about 10, and oscillating and reacting at the rotating speed of 400 r/min for 30min to cover a layer of the surface of the carrier103Pd and125a radioisotope thin film of I; then taking out the carrier, discarding the supernatant, and cleaning the surface of the carrier by water and acetone to obtain the source core.
Through the detection, the method finds that,103pd and125the deposition of I is far more than 95%, and the self-shielding rate of the carrier is 10-12%.
The embodiment also provides a palladium-103 and iodine-125 composite sealing seed source, which is prepared by welding the source core of the palladium-103 and iodine-125 composite sealing seed source in a titanium tube or a titanium alloy tube by adopting a laser welding sealing method.
EXAMPLE III
This example provides a source core of a palladium-103 and iodine-125 composite sealed seed source, which comprises a carrier and a radioisotope thin film covering the carrier, most importantly, the carrier is made of SiO2The radioactive isotope film contains103Pd and125I. here, the support surface has a plurality of microscopic micropores.
This example also provides a method of preparing a source core of a composite encapsulated seed source of palladium-103 and iodine-125 as described above, the method comprising steps 1) and 2).
Step 1), preparation of the carrier: adding proper amount of SiO2Uniformly mixing the powder and water to prepare a viscous material; preparing a die with a forming cavity, wherein the forming cavity is a cylindrical cavity with the inner diameter; pouring the viscous material into a forming cavity of the mold, and then injecting gas into the forming cavity to enable the gas pressure value in the forming cavity to reach 20 atmospheric pressures, so that the viscous material is subjected to pressure treatmentExtruding and shaping the material to obtain a strip-shaped body; taking the strip-shaped body out of the die, and placing the strip-shaped body into an oven at 800 ℃ for high-temperature baking for 1.5 hours; then taking out the strip-shaped body and cutting the strip-shaped body into a rod-shaped body with the diameter of 1.0mm and the length of 10.0 mm; the rod was lightly sanded to ensure the rod was burr free, resulting in the carrier.
Step 2) of performing a step of performing a,103pd and125and I, deposition: washing the carrier with concentrated hydrochloric acid for three times, taking 50g of the washed carrier with 51g of stable iodine, and putting the carrier and 51g of stable iodine into a reactor of 200ml103PdCl solution (radioactive dose 50mci),125ICl2Mixing the solution (radioactive dose 100mci) with water, heating to 70 deg.C, adding appropriate amount of concentrated NH3·H2Adjusting the pH value of the mixed solution to about 10, and oscillating and reacting at the rotating speed of 500 r/min for 20min to cover a layer on the surface of the carrier103Pd and125a radioisotope thin film of I; then taking out the carrier, discarding the supernatant, and cleaning the surface of the carrier by water and acetone to obtain the source core.
Through the detection, the method finds that,103pd and125the deposition of I is far more than 95%, and the self-shielding rate of the carrier is 10-12%.
The embodiment also provides a palladium-103 and iodine-125 composite sealing seed source, which is prepared by welding the source core of the palladium-103 and iodine-125 composite sealing seed source in a titanium tube or a titanium alloy tube by adopting a laser welding sealing method.
While the embodiments of the present invention have been described, the present invention is not limited to the above-mentioned embodiments, which are only illustrative and not restrictive, and those skilled in the art can make various modifications without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (10)
1. A source core of a composite sealed seed source of palladium-103 and iodine-125, the source core comprising a support and a radioisotope coated on the supportA film of elemental material, characterized in that the support consists of SiO2The radioactive isotope film contains103Pd and125I。
2. the source core of a composite sealing seed of palladium-103 and iodine-125 as claimed in claim 1 wherein said support surface has a plurality of microscopically visible micropores.
3. A method of preparing a source core of a composite sealed seed source of palladium-103 and iodine-125 as set forth in claim 1, comprising the steps of:
step 1) preparation of the carrier: adding proper amount of SiO2Uniformly mixing the powder and water, blending into a viscous material, and sequentially performing extrusion treatment, baking treatment, cutting treatment and polishing treatment on the viscous material to obtain a carrier with a fixed shape;
step 2)103Pd and125and I, deposition: putting the cleaned carrier and a proper amount of stable iodine into a container103Pd element and125heating the mixed solution of the element I to a proper temperature, oscillating at a certain rotating speed for a proper time to cover a layer on the surface of the carrier103Pd and125radioisotope thin film of I.
4. The preparation method according to claim 3, wherein the step 1) of sequentially extruding the viscous material comprises the following steps:
preparing a mould with a forming cavity therein, wherein the forming cavity is a cylindrical cavity;
and pouring the viscous material into a forming cavity of the mold, and then injecting gas into the forming cavity to enable the gas pressure value in the forming cavity to reach 15-20 atmospheric pressures, so that the viscous material is extruded and molded to obtain a strip-shaped body.
5. The method according to claim 4, wherein in the step 1), the baking process comprises: and taking out the strip-shaped body, and putting the strip-shaped body into an oven with the temperature of 200-800 ℃ for high-temperature baking for 1.5-2.0 hours.
6. The method according to claim 3, wherein in the step 2), the mixed solution is prepared from103PdCl solution,125ICl2The solution is mixed with water.
7. The method according to claim 3, wherein the temperature of the mixed solution is heated to 30 to 70 ℃ in the step 2).
8. The method according to claim 7, wherein the rotation speed in the step 2) is 40 to 500 rpm.
9. The preparation method according to claim 7, wherein in the step 2), the reaction time is 20 to 40 min.
10. A composite sealing seed source of palladium-103 and iodine-125, wherein the composite sealing seed source is made by welding the source core of any one of claims 1-2 in a titanium tube or a titanium alloy tube.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000076584A1 (en) * | 1999-06-11 | 2000-12-21 | Nycomed Amersham Plc | Iodine-containing radioactive sources |
| CN101797392A (en) * | 2010-02-03 | 2010-08-11 | 中国原子能科学研究院 | Palladium-103 and iodine-125 composite sealed seed source, source core and source core preparation method |
| CN103705948A (en) * | 2013-12-10 | 2014-04-09 | 原子高科股份有限公司 | Source-core carrier for radioactive particles, and preparation process thereof |
| CN111920965A (en) * | 2019-05-13 | 2020-11-13 | 深圳市大西塔科技有限公司 | Radioactive particle, and preparation method and application thereof |
-
2021
- 2021-02-22 CN CN202110199136.XA patent/CN112972708A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000076584A1 (en) * | 1999-06-11 | 2000-12-21 | Nycomed Amersham Plc | Iodine-containing radioactive sources |
| CN101797392A (en) * | 2010-02-03 | 2010-08-11 | 中国原子能科学研究院 | Palladium-103 and iodine-125 composite sealed seed source, source core and source core preparation method |
| CN103705948A (en) * | 2013-12-10 | 2014-04-09 | 原子高科股份有限公司 | Source-core carrier for radioactive particles, and preparation process thereof |
| CN111920965A (en) * | 2019-05-13 | 2020-11-13 | 深圳市大西塔科技有限公司 | Radioactive particle, and preparation method and application thereof |
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