CN112972591A - Liver-protecting tablet and preparation method thereof - Google Patents
Liver-protecting tablet and preparation method thereof Download PDFInfo
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- CN112972591A CN112972591A CN201911284365.0A CN201911284365A CN112972591A CN 112972591 A CN112972591 A CN 112972591A CN 201911284365 A CN201911284365 A CN 201911284365A CN 112972591 A CN112972591 A CN 112972591A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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Abstract
The invention belongs to the technical field of medical health products, and particularly relates to a liver-protecting tablet and a preparation method thereof; the liver-protecting tablet is prepared from puerarin, garlic extract, artichoke extract, medlar extract, sealwort, white hyacinth bean and vitamins. Wherein the Bulbus Allii extract is ethanol-water solution extract of Bulbus Allii, and is prepared by drying, pulverizing, sieving, stirring, and tabletting. The liver protection tablet prepared by the method can obviously reduce the fat content of the liver in vivo and reduce transaminase, and has strong practicability.
Description
Technical Field
The invention belongs to the technical field of medical health products, and particularly relates to a liver-protecting tablet and a preparation method thereof.
Background
The liver is one of the important metabolic organs of the human body, is responsible for the metabolism of alcohol, various drugs, poisons and the like, and has a biotransformation effect. With the improvement of people's life, the change of eating habits and the increase of daily compensation, the incidence of liver diseases such as fatty liver is increasing year by year. The liver-protecting tablet products on the market at present have various varieties, different component contents and no guarantee of specific drug effect. Even has certain efficacy on relieving alcoholism and chemical liver injury, and has certain health care effect on the liver. However, most of these products or the main ingredients of the products are medicines, and when the dosage is too large, side effects are generated. The long-term administration of the traditional Chinese medicine composition can accumulate in the liver, and can increase the burden of the liver to some extent, influence the normal liver function, even cause the increase of transaminase, damage to the kidney and the like.
Disclosure of Invention
The invention provides a liver-protecting tablet and a preparation method thereof to solve the problems. Solves the problem that the liver protection tablet in the prior art has harm to human body.
The method is realized by the following technical scheme:
a liver-protecting tablet comprises, by mass, 15-30 parts of puerarin, 20-30 parts of garlic extract, 15-30 parts of artichoke extract, 15-30 parts of medlar extract, 5-10 parts of rhizoma polygonati, 5-10 parts of white hyacinth bean, and 2-5 parts of vitamin C.
Further, the feed comprises the following raw materials in parts by mass: 20 parts of kudzu root, 25 parts of garlic extract, 25 parts of artichoke extract, 15 parts of medlar, 5 parts of rhizoma polygonati, 8 parts of white hyacinth bean and 2 parts of vitamin C.
Further, the garlic extract is garlic ethanol-water solution extract.
Further, the garlic ethanol-water solution extract comprises the following components in percentage by volume: ethanol: 55% of water: 45 percent.
Further, the artichoke extract is prepared by washing artichoke petals, drying, and pulverizing to particles smaller than
120μm。
Further, the rhizoma polygonati of the liver-protecting tablet is prepared by cleaning and slicing rhizoma polygonati, and drying at 85 ℃ for 5 hours.
Meanwhile, the invention provides a preparation method, which comprises the following steps:
the method comprises the following steps: drying radix Puerariae, artichoke extract, fructus Lycii, rhizoma Polygonati, and semen lablab album respectively, and pulverizing into powder with pulverizer;
step two: sieving the material obtained in the step one;
step three: adding Bulbus Allii extract and vitamin C, and stirring;
step four: and tabletting and forming the mixture by a physical tablet press to obtain the liver-protecting tablet.
In conclusion, the beneficial effects of the invention are as follows: artichoke extract has strong antioxidation, and the antioxidation is the main reason for the liver protection and liver regeneration promotion effect. Meanwhile, the white hyacinth bean is sweet in taste and slightly warm in nature, has the effects of inducing diuresis to reduce edema, clearing liver and improving vision and the like, and has good curative effect on chemical liver injury by the components such as the kudzuvine root, the rhizoma polygonati and the like. The product has good improving effect on liver protection and chemical liver injury.
Detailed Description
The following is a detailed description of the embodiments of the present invention, but the present invention is not limited to these embodiments, and any modifications or substitutions in the basic spirit of the embodiments are included in the scope of the present invention as claimed in the claims.
Example 1
The preparation method of the liver-protecting tablet comprises the following steps:
according to the weight portion, the traditional Chinese medicine composition comprises 20 portions of kudzuvine root, 25 portions of garlic extract, 25 portions of artichoke extract, 15 portions of medlar, 5 portions of rhizoma polygonati, 8 portions of white hyacinth bean and 2 portions of vitamin C.
The method comprises the following steps: drying radix Puerariae, artichoke extract, fructus Lycii, rhizoma Polygonati, and semen lablab album respectively, and pulverizing into powder with pulverizer;
step two: sieving the material obtained in the step one;
step three: adding Bulbus Allii extract and vitamin C, and stirring;
step four: and tabletting and forming the mixture by a physical tablet press to obtain the liver-protecting tablet.
Example 2
The preparation method of the liver-protecting tablet comprises the following steps:
the traditional Chinese medicine composition comprises, by weight, 15 parts of puerarin, 25 parts of garlic extract, 30 parts of artichoke extract, 15 parts of medlar extract, 5 parts of rhizoma polygonati, 5 parts of white hyacinth bean and 5 parts of vitamin C.
The method comprises the following steps: drying radix Puerariae, artichoke extract, fructus Lycii, rhizoma Polygonati, and semen lablab album respectively, and pulverizing into powder with pulverizer;
step two: sieving the material obtained in the step one;
step three: adding Bulbus Allii extract and vitamin C, and stirring;
step four: and tabletting and forming the mixture by a physical tablet press to obtain the liver-protecting tablet.
Example 3
The traditional Chinese medicine composition comprises, by weight, 20 parts of puerarin, 30 parts of garlic extract, 15 parts of artichoke extract, 15 parts of medlar extract, 10 parts of rhizoma polygonati, 5 parts of white hyacinth bean and 5 parts of vitamin C.
The method comprises the following steps: drying radix Puerariae, artichoke extract, fructus Lycii, rhizoma Polygonati, and semen lablab album respectively, and pulverizing into powder with pulverizer;
step two: sieving the material obtained in the step one;
step three: adding Bulbus Allii extract and vitamin C, and stirring;
step four: and tabletting and forming the mixture by a physical tablet press to obtain the liver-protecting tablet.
Comparative example 1
90 volunteers are selected, clinical examination shows that transaminase of stage II fatty liver with inflammation is increased to different degrees, the weight of intrahepatic fat is 8% -10% of the weight of liver, the 90 volunteers are randomly divided into three groups, and 30 people in each group take the fatty liver treatment composition of example 1, example 2 and example 3 respectively. After taking for three months, the content of intrahepatic fat is reduced to be within 5 percent, the transaminase becomes normal and is effective, the content of intrahepatic fat is reduced by more than 1 percent but more than 5 percent, the transaminase is reduced to be effective in different degrees, and the statistical results are shown in the table 1
TABLE 1 results of clinical trials for obese fatty liver (Unit: human)
| Group of | Show effect | Is effective |
| Example 1 | 16 | 14 |
| Example 2 | 18 | 12 |
| Example 3 | 11 | 19 |
As can be seen from Table 1, the liver protecting tablets of the present invention have significantly improved effects of reducing intrahepatic fat content and reducing in vivo transaminase, wherein the effect is best shown in example 2.
Claims (7)
1. The liver-protecting tablet is characterized by comprising the following raw materials, by mass, 15-30 parts of puerarin, 20-30 parts of garlic extract, 15-30 parts of artichoke extract, 15-30 parts of medlar extract, 5-10 parts of rhizoma polygonati, 5-10 parts of white hyacinth bean and 2-5 parts of vitamin C.
2. The liver protection tablet of claim 1, which is prepared from the following raw materials in parts by mass: 20 parts of kudzu root, 25 parts of garlic extract, 25 parts of artichoke extract, 15 parts of medlar, 5 parts of rhizoma polygonati, 8 parts of white hyacinth bean and 2 parts of vitamin C.
3. The liver protection tablet of claim 1 or 2, wherein the garlic extract is an ethanol-water garlic extract.
4. The ethanol-water solution extract of garlic as claimed in claim 3, wherein the ethanol-water solution extract of garlic comprises, by volume: ethanol: 55% of water: 45 percent.
5. The liver-protecting tablet of claim 1, wherein the artichoke extract is obtained by washing and drying artichoke petals and then pulverizing the artichoke petals to particles of less than 120 μm.
6. The liver-protecting tablet of claim 1, wherein the polygonatum sibiricum is washed, sliced and dried at 85 ℃ for 5 hours.
7. The liver protection tablet of claim 1, wherein the preparation method comprises the steps of:
the method comprises the following steps: drying radix Puerariae, artichoke extract, fructus Lycii, rhizoma Polygonati, and semen lablab album respectively, and pulverizing into powder with pulverizer;
step two: sieving the material obtained in the step one;
step three: adding Bulbus Allii extract and vitamin C, and stirring;
step four: and tabletting and forming the mixture by a physical tablet press to obtain the liver-protecting tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911284365.0A CN112972591A (en) | 2019-12-13 | 2019-12-13 | Liver-protecting tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911284365.0A CN112972591A (en) | 2019-12-13 | 2019-12-13 | Liver-protecting tablet and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112972591A true CN112972591A (en) | 2021-06-18 |
Family
ID=76341866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911284365.0A Withdrawn CN112972591A (en) | 2019-12-13 | 2019-12-13 | Liver-protecting tablet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112972591A (en) |
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2019
- 2019-12-13 CN CN201911284365.0A patent/CN112972591A/en not_active Withdrawn
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20210618 |