CN112972584A - Traditional Chinese medicine composition for preventing and treating gout and preparation method thereof - Google Patents

Traditional Chinese medicine composition for preventing and treating gout and preparation method thereof Download PDF

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Publication number
CN112972584A
CN112972584A CN201911277225.0A CN201911277225A CN112972584A CN 112972584 A CN112972584 A CN 112972584A CN 201911277225 A CN201911277225 A CN 201911277225A CN 112972584 A CN112972584 A CN 112972584A
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parts
extract
preventing
lily
traditional chinese
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张木坤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/732—Chaenomeles, e.g. flowering quince
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8967—Lilium, e.g. tiger lily or Easter lily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing and treating gout and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 7-13 parts of angelica aqueous extract, 2-6 parts of pawpaw alcohol extract, 11-15 parts of rhizoma corydalis aqueous extract and 1-5 parts of lily fermentation product.

Description

Traditional Chinese medicine composition for preventing and treating gout and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating gout and a preparation method thereof.
Background
Gout is a clinical syndrome caused by purine metabolic disorders or reduced uric acid excretion, characterized by hyperuricemia, repeated attacks of idiopathic acute arthritis, tophus deposition, and tophaceous chronic arthritis, which often involve the kidneys.
With the improvement of the living standard of China, the incidence rate of gout diseases is rapidly increased due to the change of the dietary structure and the living style, and the pain is severe and recurrent, so that the gout is a serious problem which troubles gout patients. The traditional gout treatment method comprises western medicine and traditional Chinese medicine, wherein the western medicine mainly uses analgesic and anti-inflammatory medicines to temporarily relieve pain, and the principle of the traditional Chinese medicine for treating gout is to take heat clearing, dampness removing, blood circulation promoting and vein relaxing as methods and promote the excretion of uric acid by adding some biological components contained in the traditional Chinese medicine. Patent No. CN201611178529.8 discloses a traditional Chinese medicine composition for treating gout, which is prepared from the following raw materials in parts by weight: 28-35 parts of herba siegesbeckiae, 13-20 parts of herba sambuci chinensis, 13-20 parts of garden balsam stem, 13-20 parts of salvia miltiorrhiza, 8-15 parts of radix rehmanniae, 8-15 parts of rhizoma polygonati, 8-15 parts of gentiana macrophylla, 8-15 parts of kadsura pepper stem, 8-15 parts of honeysuckle stem and 6-13 parts of dendrobium, and the raw materials are not easy to source, have high cost and are not suitable for general popularization.
Disclosure of Invention
The invention provides a traditional Chinese medicine composition for preventing and treating gout and a preparation method thereof to solve the technical problems.
The method is realized according to the following technical scheme:
a traditional Chinese medicine composition for preventing and treating gout comprises the following raw materials in parts by weight: 7-13 parts of angelica aqueous extract, 2-6 parts of pawpaw alcohol extract, 11-15 parts of rhizoma corydalis aqueous extract and 1-5 parts of lily fermentation extract.
Further, the traditional Chinese medicine composition for preventing and treating gout comprises the following raw materials in parts by weight: 10 parts of angelica aqueous extract, 4 parts of pawpaw alcohol extract, 13 parts of rhizoma corydalis aqueous extract and 3 parts of lily fermentation extract.
A preparation method of a traditional Chinese medicine composition for preventing and treating gout comprises the following steps:
(1) pulverizing radix Angelicae sinensis, extracting with water, separating the extractive solution from the residue, concentrating the supernatant, and concentrating to obtain radix Angelicae sinensis water extract;
(2) pulverizing rhizoma corydalis, extracting with water, centrifuging, collecting supernatant, and concentrating the supernatant to obtain rhizoma corydalis water extract;
(3) mixing papaya and ethanol, stirring at a high speed to form a suspension, extracting again, filtering an extracting solution, and concentrating a filtrate to obtain a papaya alcohol extract;
(4) crushing lily, adding water and saccharomyces cerevisiae into the lily, fermenting, taking upper layer fermentation liquor, and concentrating the fermentation liquor to obtain lily fermentation product;
(5) mixing the above components, and treating in steam environment for 10-15 min.
Preferably, the preparation method of the angelica aqueous extract comprises the following steps: pulverizing radix Angelicae sinensis to 600 mesh, extracting with water at a material-to-liquid ratio of 1:10 at 50 deg.C for 2 hr, centrifuging the extractive solution and residue, separating, concentrating the supernatant, and concentrating to obtain radix Angelicae sinensis water extract.
Preferably, the preparation steps of the rhizoma corydalis aqueous extract are as follows: pulverizing rhizoma corydalis to 600 mesh, extracting with water at 65 deg.C for 1 hr at a ratio of material to liquid of 1:7, centrifuging, collecting supernatant, and concentrating the supernatant to obtain rhizoma corydalis water extract.
Preferably, the preparation steps of the pawpaw alcohol extract are as follows: mixing papaya and ethanol according to a material-liquid ratio of 1:8, stirring at a rotating speed of 500 revolutions per minute to form a suspension, extracting at 75 ℃ for 1.5 hours, filtering the extracting solution, and concentrating the filtrate to obtain the papaya alcohol extract.
Preferably, the preparation method of the lily fermentation product comprises the following steps: pulverizing Bulbus Lilii, adding water and Saccharomyces cerevisiae into Bulbus Lilii, the concentration of Saccharomyces cerevisiae is 2.5 × 108cfu/L, the weight of the aqueous solution is 5 times of that of the lily, sealed fermentation is carried out for 2 hours, the upper layer fermentation liquor is taken after fermentation, and the fermentation liquor is concentrated to obtain the lily fermentation product.
The invention has the beneficial effects that:
1. the traditional Chinese medicine composition for preventing and treating gout disclosed by the invention is derived from natural plants, is wide in source and low in cost, and has no toxic or side effect on a human body.
2. According to the invention, dialectical formula is carried out according to the pathogenesis of gout and the drug mechanism of monarch, minister, guide and adjuvant, so that the curative effect is remarkable, both symptoms and root causes are treated, and the disease is not easy to recur after healing, clinical data analysis shows that the composition has a good curative effect on treating gout, the clinical total effective rate reaches 93.3%, the recurrence rate is less than 1%, and the prevention efficiency reaches 95.5%.
Detailed Description
The following is a detailed description of the embodiments of the present invention, but the present invention is not limited to these embodiments, and any modifications or substitutions in the basic spirit of the embodiments are included in the scope of the present invention as claimed in the claims.
Example 1
A traditional Chinese medicine composition for preventing and treating gout comprises the following raw materials in parts by weight: 7 parts of angelica aqueous extract, 2 parts of pawpaw alcohol extract, 11 parts of rhizoma corydalis aqueous extract and 1 part of lily fermentation extract.
Example 2
A traditional Chinese medicine composition for preventing and treating gout comprises the following raw materials in parts by weight: 13 parts of angelica aqueous extract, 6 parts of pawpaw alcohol extract, 15 parts of rhizoma corydalis aqueous extract and 5 parts of lily fermentation extract.
Example 3
A traditional Chinese medicine composition for preventing and treating gout comprises the following raw materials in parts by weight: 13 parts of angelica aqueous extract, 2 parts of pawpaw alcohol extract, 11 parts of rhizoma corydalis aqueous extract and 5 parts of lily fermentation extract.
Example 4
A traditional Chinese medicine composition for preventing and treating gout comprises the following raw materials in parts by weight: 10 parts of angelica aqueous extract, 4 parts of pawpaw alcohol extract, 13 parts of rhizoma corydalis aqueous extract and 3 parts of lily fermentation extract.
Examples 5 to 8
Embodiments 5 to 8 provide methods for preparing a Chinese medicinal composition for preventing and treating gout, based on the formulations of embodiments 1 to 4, respectively, comprising the steps of:
(1) pulverizing radix Angelicae sinensis to 600 mesh, extracting with water at a material-to-liquid ratio of 1:10 at 50 deg.C for 2 hr, centrifuging the extractive solution and residue, separating, concentrating the supernatant by evaporation to obtain radix Angelicae sinensis water extract;
(2) pulverizing rhizoma corydalis to 600 mesh, extracting with water at 65 deg.C for 1 hr at a material-to-liquid ratio of 1:7, centrifuging, collecting supernatant, and concentrating the supernatant to obtain rhizoma corydalis water extract;
(3) mixing papaya and ethanol according to a material-liquid ratio of 1:8, stirring at a rotating speed of 500 revolutions per minute to form a suspension, extracting at 75 ℃ for 1.5 hours, filtering the extracting solution, and concentrating the filtrate to obtain a papaya alcohol extract;
(4) pulverizing Bulbus Lilii, adding water into Bulbus LiliiAnd Saccharomyces cerevisiae with a Saccharomyces cerevisiae concentration of 2.5 × 108cfu/L, wherein the weight of the aqueous solution is 5 times of that of the lily, sealed fermentation is carried out for 2 hours, the upper layer fermentation liquor is taken after fermentation, and the fermentation liquor is concentrated to obtain lily fermentation product;
(5) mixing the above components, and treating in steam environment for 10-15 min.

Claims (7)

1. The traditional Chinese medicine composition for preventing and treating gout is characterized by comprising the following raw materials in parts by weight: 7-13 parts of angelica aqueous extract, 2-6 parts of pawpaw alcohol extract, 11-15 parts of rhizoma corydalis aqueous extract and 1-5 parts of lily fermentation extract.
2. The traditional Chinese medicine composition for preventing and treating gout according to claim 1, which comprises the following raw materials in parts by weight: 10 parts of angelica aqueous extract, 4 parts of pawpaw alcohol extract, 13 parts of rhizoma corydalis aqueous extract and 3 parts of lily fermentation extract.
3. The method for preparing a Chinese medicinal composition for preventing and treating gout as claimed in claim 1 or 2, wherein the extract is separated from the residue, and after separation, the supernatant is concentrated to obtain an aqueous extract of angelica;
(1) pulverizing rhizoma corydalis, extracting with water, centrifuging, collecting supernatant, and concentrating the supernatant to obtain rhizoma corydalis water extract;
(2) mixing papaya and ethanol, stirring at a high speed to form a suspension, extracting again, filtering an extracting solution, and concentrating a filtrate to obtain a papaya alcohol extract;
(3) crushing lily, adding water and saccharomyces cerevisiae into the lily, fermenting, taking upper layer fermentation liquor, and concentrating the fermentation liquor to obtain lily fermentation product;
(4) mixing the above components, and treating in steam environment for 10-15 min.
4. The method for preparing a Chinese medicinal composition for preventing and treating gout according to claim 3, wherein the preparation steps of the Chinese angelica aqueous extract are as follows: pulverizing radix Angelicae sinensis to 600 mesh, extracting with water at a material-to-liquid ratio of 1:10 at 50 deg.C for 2 hr, centrifuging the extractive solution and residue, separating, concentrating the supernatant, and concentrating to obtain radix Angelicae sinensis water extract.
5. The preparation method of the traditional Chinese medicine composition for preventing and treating gout according to claim 3, wherein the preparation steps of the rhizoma corydalis aqueous extract are as follows: pulverizing rhizoma corydalis to 600 mesh, extracting with water at 65 deg.C for 1 hr at a ratio of material to liquid of 1:7, centrifuging, collecting supernatant, and concentrating the supernatant to obtain rhizoma corydalis water extract.
6. The preparation method of the traditional Chinese medicine composition for preventing and treating gout according to claim 3, wherein the steps of preparing the papaya alcohol extract are as follows: mixing papaya and ethanol according to a material-liquid ratio of 1:8, stirring at a rotating speed of 500 revolutions per minute to form a suspension, extracting at 75 ℃ for 1.5 hours, filtering the extracting solution, and concentrating the filtrate to obtain the papaya alcohol extract.
7. The preparation method of the traditional Chinese medicine composition for preventing and treating gout according to claim 3, wherein the preparation method of the lily fermented product comprises the following steps: pulverizing Bulbus Lilii, adding water and Saccharomyces cerevisiae into Bulbus Lilii, the concentration of Saccharomyces cerevisiae is 2.5 × 108cfu/L, the weight of the aqueous solution is 5 times of that of the lily, sealed fermentation is carried out for 2 hours, the upper layer fermentation liquor is taken after fermentation, and the fermentation liquor is concentrated to obtain the lily fermentation product.
CN201911277225.0A 2019-12-12 2019-12-12 Traditional Chinese medicine composition for preventing and treating gout and preparation method thereof Withdrawn CN112972584A (en)

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Application Number Priority Date Filing Date Title
CN201911277225.0A CN112972584A (en) 2019-12-12 2019-12-12 Traditional Chinese medicine composition for preventing and treating gout and preparation method thereof

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Application Number Priority Date Filing Date Title
CN201911277225.0A CN112972584A (en) 2019-12-12 2019-12-12 Traditional Chinese medicine composition for preventing and treating gout and preparation method thereof

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Application publication date: 20210618