CN112972081A

CN112972081A - Degradable anti-displacement bracket for digestive tract and preparation method thereof

Info

Publication number: CN112972081A
Application number: CN202110212003.1A
Authority: CN
Inventors: 蒯小玲; 杨宇民
Original assignee: Nantong University; Affiliated Hospital of Nantong University
Current assignee: Nantong University; Affiliated Hospital of Nantong University
Priority date: 2021-02-25
Filing date: 2021-02-25
Publication date: 2021-06-18
Anticipated expiration: 2041-02-25
Also published as: CN112972081B

Abstract

The invention discloses a degradable anti-displacement bracket for a digestive tract, which comprises a bracket body woven by degradable filaments; the bracket body is provided with a plurality of raised barbs. The degradable silk is used as the raw material of the stent, so that the tissue compatibility is good, and the foreign body sensation of the stent is less. The stent body is provided with a plurality of raised barbs which can effectively prevent the stent from shifting, and the poly-p-dioxanone thread is adopted, so that the stent has good tissue compatibility, has high strength retention rate in a human body, has the strength retention rate of more than 80% after 2 weeks and is 13% after 8 weeks, is more than polyglycolide and polylactic acid, has better flexibility than polyglycolide and polylactide, and is more suitable for digestive tracts with peristaltic functions.

Description

Degradable anti-displacement bracket for digestive tract and preparation method thereof

Technical Field

The invention relates to the technical field of digestive tract stents, in particular to a degradable digestive tract anti-displacement stent and a preparation method thereof.

Background

Stent intervention has found numerous applications in the clinic of vascular surgery, thoracic surgery, urology, and digestive surgery. By utilizing medical imaging equipment such as X-ray fluoroscopy, CT positioning, B-ultrasonic and the like, and by means of special catheters or instrument introduction, an interventional therapist can already deliver the stent to almost all blood vessel branches, digestive tract lumens and other specific focus parts of a human body.

The currently used interventional stents are mainly metal non-degradable stents, such as nitinol stents, which have the advantages that nitinol has shape memory and the stent can recover deformation at body temperature, thereby providing sufficient expansion and support force to the lesion site. However, its disadvantages are also evident, such as: (1) the non-degradable metal stent is used as a foreign body of a human body, has poor adaptability with the human body, and is easy to cause long-term complications such as continuous pain, foreign body inflammatory reaction, intimal hyperplasia, late thrombosis and the like; (2) if the non-degradable metal stent needs to be taken out, secondary operation is needed, so that the pain, the risk and the medical expense of a patient are increased; (3) if the non-degradable metal stent slips to the intestines and stomach or other parts, medical accidents such as internal injury, bleeding and even perforation can be caused.

Therefore, non-degradable metal stents are currently used in the field of the digestive system mainly in some palliative treatments of patients with advanced tumors, while for some benign strictures or obstructions, such as the digestive tract obstruction caused by strictures after ESD surgery, achalasia of the cardia, huge diverticular compartments, etc., permanent metal stents are not suitable to be placed in the treatment. Benign stenotic lesions require stent removal after treatment is over, which is not met by non-degradable metal stents.

Disclosure of Invention

The invention aims to provide a degradable anti-displacement bracket for the alimentary canal, which can prevent the bracket from displacing and reduce the foreign body sensation of the bracket.

In order to solve the technical problems, the invention adopts the following technical scheme: a digestive tract degradable anti-displacement stent comprises a stent body woven by degradable filaments; the bracket body is provided with a plurality of raised barbs.

Further, the barb and the support body integrated into one piece.

Further, the degradable filaments are polydioxanone threads.

Furthermore, the whole bracket body is of a dumbbell-shaped structure and comprises a bracket main body in the middle and supporting bodies at two ends; the diameter of the support body is larger than that of the support main body.

Furthermore, the stent main body and the support body are both of a rhombic net structure.

Further, the outer end of the supporting body is provided with an elastic supporting ring.

Further, the support body is longitudinally woven with a plurality of axial limiting rings between the elastic support rings, and the woven corrugated structure between two adjacent axial limiting rings enables the support body to have axial flexibility.

And further, cutting the surface of the degradable filament by using a cutting tool to form barbs with small thorn-shaped protrusions, and weaving the degradable filament with the barbs to form the stent body.

Furthermore, the elastic support rings are woven into the two ends of the bracket body to form the elastic support body.

Furthermore, the barbs of the small thorn-shaped protrusions are spirally distributed on the surface of the degradable filament.

The invention has the beneficial effects that:

1) the degradable silk is used as the raw material of the stent, so that the tissue compatibility is good, and the foreign body sensation of the stent is less.

2) The support body is provided with the plurality of raised barbs, so that the support is effectively prevented from shifting.

3) The poly (p-dioxanone) thread adopted by the invention has good tissue compatibility, can maintain the strength for a long time, has high strength retention rate in a human body, the strength retention rate of more than 80% in 2 weeks and 13% in 8 weeks, are both greater than polyglycolide and polylactic acid, have better flexibility than polyglycolide and polylactide and are more suitable for digestive tracts with peristaltic function.

4) When the stent is woven, the supporting force is transversely kept, and certain axial telescopic compliance is longitudinally kept, so that the stent is suitable for intestinal peristalsis.

Drawings

The invention is further illustrated by the following figures and examples.

Fig. 1 is a schematic structural view of the present invention.

Fig. 2 is a schematic view of the woven structure of the present invention.

Fig. 3 is a partial schematic view of a stent body of the present invention.

FIG. 4 is a schematic view of a degradable filament delivery channel of the present invention.

Fig. 5 is a schematic view of the position of the cutting knife.

Fig. 6 is a schematic view of a cutting knife structure.

Detailed Description

The technical solution of the present invention will be clearly and completely described by the following detailed description.

In the description of the present invention, it is to be understood that the terms "middle", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on those shown in the drawings, are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and thus, should not be construed as limiting the present invention. The terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.

In addition, unless expressly stated or limited otherwise, the terms "mounted," "connected," "secured," and the like are intended to be inclusive and mean, for example, that there may be a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the present invention, unless otherwise expressly stated or limited, "above" or "below" a first feature means that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact with each other via another feature therebetween. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.

Example 1

Referring to fig. 1-3, the degradable anti-displacement stent for the digestive tract of the invention comprises a stent body 1 woven by degradable filaments; the bracket body is provided with a plurality of raised barbs 2. The degradable filament adopts poly (p-dioxanone) thread. The barb on the bracket body and the bracket body are integrally formed.

According to the invention, the plurality of barbs are arranged on the bracket body, so that the bracket is effectively prevented from shifting.

The stent main body and the support body are both of a rhombic net structure. The support main body of the rhombic net-shaped structure endows the support with larger radial supporting force and good axial compliance.

According to the support body, the plurality of axial limiting rings are longitudinally woven between the elastic support rings, and the woven corrugated structure between every two adjacent axial limiting rings enables the support body to have axial flexibility.

The whole bracket body of the invention is in a dumbbell-shaped structure and comprises a bracket main body 11 in the middle and supporting bodies 12 at two ends; the diameter of the support body is larger than that of the support main body. The support body with the dumbbell-shaped structure can prevent the support from shifting.

The outer end of the support body of the invention is provided with an elastic support ring 13. The elastic support ring arranged at the outer end of the support body can enable the displacement support to be well attached to the side wall of the digestive tract, and the support body can be quickly recovered after being deformed.

Example 2

The invention adopts a cutting tool to cut the surface of the degradable filament to form barbs of the small thorn-shaped protrusions, and weaves the degradable filament with the barbs to form the stent body, wherein the barbs of the small thorn-shaped protrusions are spirally distributed on the surface of the degradable filament. The elastic support rings are woven into the two ends of the bracket body to form the elastic support body.

The shearing angle of the barb is 145-175 degrees, the shearing depth is one third of the diameter of the degradable filament, and the shearing length is generally equal to or slightly larger than the diameter of the degradable filament.

In order to achieve a better displacement prevention effect, the inclination directions of two adjacent barbs are opposite.

As shown in fig. 4-6, the present invention employs four cutting knives 3 to cut the surface of the degradable filaments, and the degradable filaments are conveyed through the degradable filament conveying passage; one end of the degradable silk conveying channel is a degradable silk winding shaft, the other end of the degradable silk unwinding shaft is a degradable silk unwinding shaft, and the winding shaft and the unwinding shaft are both driven by a motor.

The degradable silk conveying channel consists of limiting rings 41 at two ends and four connecting rods 42 for connecting the limiting rings at the two ends, wherein the four connecting rods are uniformly distributed; be cutting region 43 between two adjacent connecting rods, four connecting rods divide into four cutting regions with degradable silk transfer passage, all set up in a cutting knife 3 in every cutting region, and four cutting knives 3 distribute in proper order from the front to the back.

The cutting knife 3 of the invention is arranged on a knife seat 5, and the knife seat 5 is driven by a cutting driving device 6 to cut. According to the invention, the limit stops 7 are further arranged on the two sides of the cutter holder 5, the limit stops 7 are provided with adjusting components for adjusting the distance of the limit stops 7 extending out of the cutter holder, so that the cutting depth of the cutting knife is adjusted, and after the driving device drives the cutter holder to cut, the limit stops 7 can be clamped on the connecting rods on the two sides of the cutting area, so that the cutting knife is prevented from being inserted too deeply.

While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the spirit and scope of the invention.

Claims

1. The utility model provides a alimentary canal degradable prevents displacement support which characterized in that: comprises a stent body woven by degradable filaments; the bracket body is provided with a plurality of raised barbs.

2. The degradable digestive tract stent capable of preventing displacement according to the patent claim 1 is characterized in that: the barb and the support body integrated into one piece.

3. The degradable digestive tract stent against displacement according to claim 1, wherein: the degradable silk is poly (p-dioxanone) thread.

4. The degradable digestive tract stent against displacement according to claim 1, wherein: the whole bracket body is of a dumbbell-shaped structure and comprises a bracket main body in the middle and supporting bodies at two ends; the diameter of the support body is larger than that of the support main body.

5. The degradable digestive tract stent against displacement according to claim 4, wherein: the support main body and the support body are both of a rhombic net structure.

6. The degradable digestive tract stent against displacement according to claim 4, wherein: the outer end of the supporting body is provided with an elastic supporting ring.

7. The degradable digestive tract stent against displacement according to claim 6, wherein: the supporting body is provided with a plurality of axial limiting rings which are woven between the elastic supporting rings along the longitudinal direction, and the corrugated structure woven between every two adjacent axial limiting rings enables the supporting body to have axial flexibility.

8. The method for preparing the degradable anti-displacement bracket for the digestive tract, which is disclosed by claim 1, is characterized in that: cutting the surface of the degradable filament by using a cutting tool to form small barbed raised barbs, and weaving the degradable filament with the barbs to form the support body.

9. The method for preparing the degradable anti-displacement bracket for the digestive tract according to the claim 8, which is characterized in that: the elastic support rings are woven into the two ends of the bracket body to form the elastic support body.

10. The method for preparing the degradable anti-displacement bracket for the digestive tract according to the claim 8, which is characterized in that: the barbs of the small thorn-shaped bulges are spirally distributed on the surface of the degradable filament.