CN112935568A - Application of infrared laser on vaccine bottle sealing hole - Google Patents
Application of infrared laser on vaccine bottle sealing hole Download PDFInfo
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- CN112935568A CN112935568A CN202110159506.7A CN202110159506A CN112935568A CN 112935568 A CN112935568 A CN 112935568A CN 202110159506 A CN202110159506 A CN 202110159506A CN 112935568 A CN112935568 A CN 112935568A
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- vaccine
- vaccine bottle
- laser
- bottle
- hole
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- 229960005486 vaccine Drugs 0.000 title claims abstract description 116
- 238000007789 sealing Methods 0.000 title claims abstract description 55
- 238000012360 testing method Methods 0.000 claims abstract description 28
- 238000010330 laser marking Methods 0.000 claims abstract description 27
- 238000012545 processing Methods 0.000 claims abstract description 22
- 239000005060 rubber Substances 0.000 claims abstract description 22
- 239000007788 liquid Substances 0.000 claims abstract description 18
- 239000000463 material Substances 0.000 claims abstract description 18
- 238000002347 injection Methods 0.000 claims abstract description 15
- 239000007924 injection Substances 0.000 claims abstract description 15
- 238000003466 welding Methods 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 4
- 230000002265 prevention Effects 0.000 abstract description 3
- 230000000694 effects Effects 0.000 description 9
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 3
- 239000012815 thermoplastic material Substances 0.000 description 3
- 239000000428 dust Substances 0.000 description 2
- 238000010329 laser etching Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012858 packaging process Methods 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 239000002985 plastic film Substances 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/36—Removing material
- B23K26/362—Laser etching
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/70—Auxiliary operations or equipment
- B23K26/702—Auxiliary equipment
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- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Plasma & Fusion (AREA)
- Mechanical Engineering (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention relates to the technical field of medical treatment, and discloses an application of infrared laser on vaccine bottle hole sealing. Firstly, preparing a sealed vaccine bottle, and injecting vaccine liquid into the vaccine bottle to form an injection hole; designing a drawing file for laser marking, and adjusting the size of an area needing hole sealing on the drawing file; placing the prepared vaccine bottle on a processing platform, and fixing the vaccine bottle; selecting infrared laser marking equipment, adjusting the laser focal length to a proper position, and setting the processing parameters of the infrared laser marking equipment according to the drawing file; the infrared laser generated by the laser marking equipment acts on the surface of the liquid injection hole of the vaccine bottle rubber plug, so that the surface material is melted and flows into the liquid injection hole and is blocked to realize hole sealing; and taking out the sealed vaccine bottle from the processing platform, and testing the sealed vaccine bottle to obtain the sealed vaccine bottle meeting the requirements. The invention realizes the hole sealing of the vaccine bottle based on the infrared laser, can save time and cost, is beneficial to the pollution prevention and control of the vaccine and improves the efficiency.
Description
Technical Field
The invention relates to the technical field of medical treatment, in particular to application of infrared laser to vaccine bottle hole sealing.
Background
The vaccine bottle is used as a bearing device of the vaccine, and has extremely high requirement on the sealing performance of the product in the preparation process. The glass bottle body is made of low-temperature-resistant and wear-resistant medium borosilicate glass, and is sealed by a rubber plug and an aluminum cover. In the traditional vaccine bottling process, a glass bottle needs to be disinfected in a dust-free and non-toxic workshop, a vaccine is injected, then the glass bottle is sealed, an air tightness test is carried out, and finally, a disinfection and sterilization treatment is carried out. During the process of injecting the vaccine bottle into the sealed bottle, the bottle mouth is opened, so that the risk of secondary pollution exists. And laser is used, the sealed vaccine bottle needle tube can be injected into a vaccine sample, and then laser is used for blocking the needle hole in a hot melting mode.
Disclosure of Invention
The invention aims to solve the technical problems in the prior art, provides an application of an infrared laser-based vaccine bottle sealing hole, can save time and cost, is beneficial to pollution prevention and control of a vaccine, and improves efficiency.
In order to solve the problems proposed above, the technical scheme adopted by the invention is as follows:
an application of infrared laser on vaccine bottle sealing holes specifically comprises the following steps:
preparing a sealed vaccine bottle, and injecting vaccine liquid into the vaccine bottle to form an injection hole;
designing a drawing file for laser marking, and adjusting the size of an area needing hole sealing on the drawing file;
placing the prepared vaccine bottle on a processing platform and fixing;
selecting infrared laser marking equipment, adjusting the laser focal length to a proper position, and setting the processing parameters of the infrared laser marking equipment according to the drawing file;
the infrared laser acts on the surface of the liquid injection hole of the vaccine bottle rubber plug, so that the surface material is melted and flows into the liquid injection hole and is blocked to realize hole sealing;
and taking out the sealed vaccine bottle from the processing platform, and testing the sealed vaccine bottle to obtain the sealed vaccine bottle meeting the requirements.
Furthermore, the infrared laser marking device adopts an infrared nanosecond laser with the wavelength of 1064nm-1945nm, the maximum power of the laser is 15W, and the laser marking range is 100 mm-100 mm.
Further, the test comprises a sealing performance test and a welding depth test.
Further, the tightness test is as follows: during testing, water is injected into the vaccine bottle from a position outside the hole sealing area, air in the vaccine bottle is compressed to increase the air pressure in the vaccine bottle, and if no air leakage exists in the vaccine bottle, the requirement on sealing performance is met.
Further, after the vaccine bottle is sealed by normal laser, the air pressure which can be borne by the inner cavity of the vaccine bottle is 400 KPa.
Further, the welding depth test is as follows: during testing, the rubber plug of the vaccine bottle is taken out, the actual complete coverage depth is measured after the rubber plug is cut open, and the depth reaches a preset value and meets the requirement.
Further, the vaccine bottle is after normal laser hole sealing welding, the degree of depth can reach more than 90 um.
Furthermore, the liquid injection hole is a through pinhole formed by injecting the vaccine liquid into the vaccine bottle in a needle tube manner.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, infrared laser generated by the infrared laser marking equipment acts on the surface of the pinhole of the rubber plug to melt the material, and the melted material flows into the pinhole to block the pinhole, so that hole sealing is realized, the packaging process of the vaccine is simplified, and the efficiency is improved under the condition of ensuring the quality; in addition, the secondary pollution probability of the vaccine in the packaging process is reduced through the laser effect, redundant consumable materials are not needed in the processing, the cost is low, the efficiency is high, and the method is safe and environment-friendly; the research and development efficiency can be improved, and the next process can be entered by injecting and bottling the developed vaccine and sealing the hole with laser.
Drawings
In order to more clearly illustrate the solution of the present invention, the drawings used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without inventive efforts. Wherein:
fig. 1 is a flow chart of the present invention based on the application of infrared laser to the sealed hole of the vaccine bottle.
Fig. 2 is a schematic diagram of the present invention based on the application of infrared laser to the sealing hole of the vaccine bottle.
Detailed Description
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs; the terminology used in the description presented herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention, e.g., the terms "length," "width," "upper," "lower," "left," "right," "front," "rear," "vertical," "horizontal," "top," "bottom," "inner," "outer," etc., refer to an orientation or position based on that shown in the drawings, are for convenience of description only and are not to be construed as limiting of the present disclosure.
The terms "comprising" and "having," and any variations thereof, in the description and claims of this invention and the description of the above figures, are intended to cover non-exclusive inclusions; the terms "first," "second," and the like in the description and in the claims, or in the drawings, are used for distinguishing between different objects and not necessarily for describing a particular sequential order. In the description and claims of the present invention and in the description of the above figures, when an element is referred to as being "fixed" or "mounted" or "disposed" or "connected" to another element, it may be directly or indirectly located on the other element. For example, when an element is referred to as being "connected to" another element, it can be directly or indirectly connected to the other element.
Furthermore, reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the invention. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is explicitly and implicitly understood by one skilled in the art that the embodiments described herein can be combined with other embodiments.
Referring to fig. 1, the invention provides an application of an infrared laser on a vaccine bottle sealing hole, which specifically comprises the following steps:
step S1: preparing a sealed vaccine bottle, and injecting vaccine liquid into the vaccine bottle, wherein a penetrating injection hole is formed in a sealed plastic sheet of the vaccine bottle, so that the sealing performance of the vaccine bottle is influenced. Specifically, the vaccine bottle is subjected to disinfection and sterilization treatment, vaccine liquid is injected into the vaccine bottle in a needle tube mode, and the liquid injection hole is a through needle hole.
In this step S1, the rubber plug of the vaccine bottle, i.e., the sealing plastic sheet, is made of a thermoplastic material, such as TPE, so as to prevent the material from generating dust during laser processing, and the boiling point of the material cannot be too low, thereby ensuring that the material is heated and not directly vaporized during laser processing.
Step S2: designing a marked figure file, and adjusting the size of an area needing hole sealing on the figure file. The designed drawing file is used for managing and controlling the laser processing route and the size of the processing area, and is generally slightly larger than the surface size of the pinhole.
Step S3: and (4) placing the prepared vaccine bottle on a processing platform, and fixing the vaccine bottle.
Step S4: and selecting infrared laser marking equipment, adjusting the laser focal length to a proper position, and setting the processing parameters of the laser marking equipment according to the drawing file. Specifically, the designed drawing is imported to a laser marking device, and then parameter setting is performed.
In step S4, an infrared nanosecond laser with a wavelength of 1064nm-1945nm is used, the maximum power of the laser is 15W, and the laser marking range is 100mm x 100 mm. In the embodiment of the invention, the hole sealing is carried out by adopting the infrared laser, and the heat effect generated by the laser beam with longer wavelength is larger, so that the temperature of an action area can be uniformly increased in a shorter time, and the action area is further melted; however, use of laser light having a short wavelength such as ultraviolet laser light easily causes embrittlement of the material, thereby generating dust. In addition, the infrared laser has a large light spot, and can avoid heat concentration so as to carbonize the material.
Step S5: the infrared laser generated by the laser marking equipment acts on the surface of the rubber plug of the vaccine bottle, so that the rubber plug is melted under the action of high temperature, and the needle hole is completely covered after the rubber plug is re-condensed, thereby achieving the effect of complete sealing.
In the step S5, the laser generated by the laser marking device acts on the position of the pinhole of the thermoplastic material to generate a thermal effect to melt the material on the surface, and the melted material flows into the pinhole under the guiding of the laser scanning direction and the action of gravity, and the pinhole is completely blocked, thereby showing the final effect. The method has the advantages of good hole sealing air tightness, no pollution, no influence on the physical and chemical properties of the material in the process and higher hole sealing efficiency.
Step S6: and taking out the sealed vaccine bottle from the processing platform, testing the sealed vaccine bottle, and obtaining the sealed vaccine bottle meeting the requirements after the test is completed.
In step S6, since the hole sealing position has a slight protrusion after the laser hole sealing is completed, the plastic at the edge of the welding position is condensed after melting, and the performance of the material is not affected. After the laser hole sealing, the vaccine bottle needs to be tested in two aspects, namely, the sealing performance test and the welding depth test.
The tightness test is as follows: when in testing, the needle is used for injecting water into the vaccine bottle from the position outside the hole sealing area, the air in the vaccine bottle is compressed to increase the air pressure in the vaccine bottle, and whether the vaccine bottle has air leakage or not is observed, and the requirement can be met if no air leakage exists. Further, after the vaccine bottle is sealed by normal laser, the air pressure which can be borne by the inner cavity of the vaccine bottle is 400 KPa.
The welding depth test is as follows: during testing, the rubber plug of the vaccine bottle is taken out, the actual complete coverage depth is measured after splitting, and the depth reaches a preset value, so that the requirement can be met. Further, after the vaccine bottle is subjected to normal laser hole sealing welding, the depth can reach more than 90 um.
In the above, during laser processing, the position, the spot size and the shape of the laser focus and the laser etching parameters have an important influence on the processing effect. The position of a laser focus must be found accurately in the laser marking process, too much deflection causes heat to be incapable of melting the thermoplastic material, so that the sealing effect does not meet the requirement, and the sealing tightness is poor due to the fact that the size and the shape of a light spot do not meet the standard. In the embodiment of the invention, the adopted laser processing parameters are shown in the table I, and the proportion can be properly adjusted according to the effect.
Watch 1
In the embodiment of the invention, the times, speed and filling intervals of laser marking can be adjusted according to the hole sealing effect, the material properties are different, and the used parameters also need to be properly adjusted. If the situation that the air tightness does not reach the standard is detected, the energy of the laser needs to be increased, or the marking speed needs to be reduced, the marking times needs to be increased, the filling distance needs to be reduced, and the like.
Compared with the traditional process, the hole sealing method provided by the invention has the advantages that the time and the cost can be saved by adopting laser hole sealing, the pollution prevention and control of the vaccine are facilitated, in addition, the medical research and development efficiency can be improved, a vaccine company only needs to inject and bottle the developed vaccine, an infrared laser marking machine is loaded on a production line, and the next process can be accessed by using laser hole sealing.
The use of the above-described infrared laser-based vaccine vial closure is further illustrated by the following specific examples.
(1) Preparing a sealed vaccine bottle which is sterilized, puncturing the rubber of the vaccine bottle by using a medical needle tube, injecting a medicament into the vaccine bottle, and drawing out the needle tube to see a through hole in the rubber.
(2) Editing laser marking image files and laser etching parameters, and adjusting the size of an area needing hole sealing on the image files. Specifically, the marked graph is set to be a square with the diameter of 2mm, the graph is placed at the position of the pinhole, the graph is filled in a mode that the filling direction is contracted from outside to inside, and therefore the graph is beneficial to the flow of the hole sealing plastic material in a molten state to the inside of the pinhole.
(3) And (4) placing the prepared vaccine bottle on a processing platform, and fixing the vaccine bottle.
(4) And (3) placing the vaccine bottle under infrared laser, starting the infrared laser marking equipment, adjusting the laser focal distance to a proper position, and guiding the designed figure file into the laser marking equipment.
(5) The laser emits light to melt the surface material of the rubber plug of the vaccine bottle and flow into the liquid injection hole, and the rubber plug is plugged to realize hole sealing. When the welding surface is observed, obvious welding spots can be seen on the welding surface, and the positions of the original needle holes can not be seen visually, so that obvious bulges can be seen.
(6) The vaccine bottle after taking out the hole sealing from the processing platform to test it, include:
and (3) testing the welding depth: the sealing rubber of the vaccine bottle is taken down, split at the welding position, and then the melting depth is measured, the depth of the test result can reach 90um, the welding position is broken off with great force, the pin holes in the welding position are completely eliminated, the secondary cracking is not easy, and the requirements can be met.
And (3) testing the sealing property: clear water is injected into the vaccine bottle at other positions outside the hole sealing area by using an injector, so that the air pressure in the vaccine bottle is increased, and the rubber pad does not bulge when the vaccine bottle is not pressurized. After pressurization, the rubber pad swells and lasts for 2 minutes under the air pressure of 400KPa, and if the rubber pad can keep the swelling state, the air leakage condition in the vaccine bottle is proved, and the requirement can be met.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, and simplifications are intended to be included in the scope of the present invention.
Claims (8)
1. An application based on infrared laser on bacterin bottle seals hole which characterized in that: the method specifically comprises the following steps:
preparing a sealed vaccine bottle, and injecting vaccine liquid into the vaccine bottle to form an injection hole;
designing a drawing file for laser marking, and adjusting the size of an area needing hole sealing on the drawing file;
placing the prepared vaccine bottle on a processing platform and fixing;
selecting infrared laser marking equipment, adjusting the laser focal length to a proper position, and setting the processing parameters of the infrared laser marking equipment according to the drawing file;
the infrared laser acts on the surface of the liquid injection hole of the vaccine bottle rubber plug, so that the surface material is melted and flows into the liquid injection hole and is blocked to realize hole sealing;
and taking out the sealed vaccine bottle from the processing platform, and testing the sealed vaccine bottle to obtain the sealed vaccine bottle meeting the requirements.
2. The use of an infrared-based laser for sealing a hole in a vaccine vial according to claim 1, wherein: the infrared laser marking device adopts an infrared nanosecond laser with the wavelength of 1064nm-1945nm, the maximum power of the laser is 15W, and the laser marking range is 100 mm-100 mm.
3. The use of an infrared-based laser for sealing a hole in a vaccine vial according to claim 1, wherein: the test of the vaccine bottle comprises a tightness test and a welding depth test.
4. The use of an infrared laser based vaccine vial closure according to claim 3, wherein: the tightness test is as follows: during testing, water is injected into the vaccine bottle from the position outside the hole sealing area, air in the vaccine bottle is compressed to increase the air pressure in the vaccine bottle, and if no air leakage exists in the vaccine bottle, the requirement on sealing performance is met.
5. The use of an infrared laser based vaccine vial closure according to claim 4, wherein: after the vaccine bottle is sealed by normal laser, the air pressure which can be borne by the inner cavity of the vaccine bottle is 400 KPa.
6. The use of an infrared laser based vaccine vial closure according to claim 3, wherein: the welding depth test is as follows: during testing, the rubber plug of the vaccine bottle is taken out, the actual complete coverage depth is measured after the rubber plug is cut open, and the depth reaches a preset value and meets the requirement.
7. The use of an infrared-based laser for sealing a hole in a vaccine vial according to claim 6, wherein: the vaccine bottle is after normal laser hole sealing welding, the degree of depth can reach more than 90 um.
8. The use of an infrared-based laser for sealing a hole in a vaccine vial according to claim 1, wherein: the liquid injection hole is used for injecting vaccine liquid into the vaccine bottle in a needle tube mode, and the liquid injection hole is a through needle hole.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110159506.7A CN112935568A (en) | 2021-02-04 | 2021-02-04 | Application of infrared laser on vaccine bottle sealing hole |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110159506.7A CN112935568A (en) | 2021-02-04 | 2021-02-04 | Application of infrared laser on vaccine bottle sealing hole |
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2021
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| US5549141A (en) * | 1994-07-19 | 1996-08-27 | Kvm Technologies, Inc. | Liquid container sample transfer method and apparatus |
| CN103818625A (en) * | 2001-02-12 | 2014-05-28 | 因斯蒂尔医学技术有限公司 | Medicament vial having a heat-sealable cap, and apparatus and method for filling the vial |
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Application publication date: 20210611 |