CN112930395A - 靶向rna的融合蛋白组合物和使用方法 - Google Patents

靶向rna的融合蛋白组合物和使用方法 Download PDF

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CN112930395A
CN112930395A CN201980050249.4A CN201980050249A CN112930395A CN 112930395 A CN112930395 A CN 112930395A CN 201980050249 A CN201980050249 A CN 201980050249A CN 112930395 A CN112930395 A CN 112930395A
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rna
sequence
present disclosure
composition
seq
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D·A·内尔斯
R·巴特拉
E·杨
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Rocana Biological Co ltd
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CN201980050249.4A 2018-06-08 2019-06-07 靶向rna的融合蛋白组合物和使用方法 Pending CN112930395A (zh)

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US201862682271P 2018-06-08 2018-06-08
US62/682,271 2018-06-08
PCT/US2019/036021 WO2019236982A1 (en) 2018-06-08 2019-06-07 Rna-targeting fusion protein compositions and methods for use

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US (3) US20200071718A1 (https=)
EP (1) EP3802812A4 (https=)
JP (1) JP2021526858A (https=)
KR (1) KR20210058806A (https=)
CN (1) CN112930395A (https=)
AU (1) AU2019280990A1 (https=)
CA (1) CA3102779A1 (https=)
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CN114835776A (zh) * 2022-04-08 2022-08-02 陕西师范大学 一种靶向Smad4/PELO相互作用的抵抗肿瘤转移小分子多肽及应用
WO2023208256A1 (zh) * 2022-04-26 2023-11-02 北京干细胞与再生医学研究院 经分离的Cas13蛋白、基于它的基因编辑系统及其用途

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US9499805B2 (en) 2010-06-18 2016-11-22 The University Of North Carolina At Chapel Hill Methods and compositions for synthetic RNA endonucleases
US20190284553A1 (en) 2018-03-15 2019-09-19 KSQ Therapeutics, Inc. Gene-regulating compositions and methods for improved immunotherapy
AU2020208346B2 (en) 2019-01-14 2026-01-29 University Of Rochester Targeted nuclear RNA cleavage and polyadenylation with CRISPR-cas
EP4004206A1 (en) * 2019-07-23 2022-06-01 University of Rochester Targeted rna cleavage with crispr-cas
WO2022020431A2 (en) * 2020-07-21 2022-01-27 Trustees Of Boston University Inducible control of gene expression
CN112126645B (zh) * 2020-09-11 2021-06-01 广州吉赛生物科技股份有限公司 一种环形rna敲低方法及其应用
CN112430597A (zh) * 2020-11-24 2021-03-02 深圳市瑞吉生物科技有限公司 一种使目的基因沉默的CasRx制剂及其应用
KR20230127221A9 (ko) * 2020-12-01 2024-12-06 로카나바이오 인크. Cag 반복 질환을 치료하기 위한 rna 표적화 조성물 및 방법
US20240108751A1 (en) * 2020-12-01 2024-04-04 Locanabio, Inc. Rna-targeting compositions and methods for treating myotonic dystrophy type 1
GB202105455D0 (en) 2021-04-16 2021-06-02 Ucl Business Ltd Composition
WO2022256414A1 (en) * 2021-06-02 2022-12-08 The Regents Of The University Of California Rna recognition complex and uses thereof
US20250163475A1 (en) * 2021-12-27 2025-05-22 Gracell Biotechnologies (Shanghai) Co., Ltd. Systems and methods for cell modification
US20250382596A1 (en) * 2022-10-28 2025-12-18 The Regents Of The University Of California Recombinant enhanced antiviral restrictors
CN115820603B (zh) * 2022-11-15 2024-07-05 吉林大学 一种基于dCasRx-NSUN6单基因特异性M5C修饰编辑方法

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JP6793547B2 (ja) * 2013-12-12 2020-12-02 ザ・ブロード・インスティテュート・インコーポレイテッド 最適化機能ＣＲＩＳＰＲ−Ｃａｓ系による配列操作のための系、方法および組成物
US10330674B2 (en) 2015-01-13 2019-06-25 Massachusetts Institute Of Technology Pumilio domain-based modular protein architecture for RNA binding
EP3303634B1 (en) 2015-06-03 2023-08-30 The Regents of The University of California Cas9 variants and methods of use thereof
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US20130178513A1 (en) * 2003-09-18 2013-07-11 Isis Pharmaceuticals, Inc. Modulation of eif4e expression
US20110002981A1 (en) * 2006-12-20 2011-01-06 Kolattukudy Pappachan E MCPIP Protection Against Cardiac Dysfunction
US20170088845A1 (en) * 2014-03-14 2017-03-30 The Regents Of The University Of California Vectors and methods for fungal genome engineering by crispr-cas9
WO2017091630A1 (en) * 2015-11-23 2017-06-01 The Regents Of The University Of California Tracking and manipulating cellular rna via nuclear delivery of crispr/cas9

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114835776A (zh) * 2022-04-08 2022-08-02 陕西师范大学 一种靶向Smad4/PELO相互作用的抵抗肿瘤转移小分子多肽及应用
CN114835776B (zh) * 2022-04-08 2023-09-01 陕西师范大学 一种靶向Smad4/PELO相互作用的抵抗肿瘤转移小分子多肽及应用
WO2023208256A1 (zh) * 2022-04-26 2023-11-02 北京干细胞与再生医学研究院 经分离的Cas13蛋白、基于它的基因编辑系统及其用途

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US20200123569A1 (en) 2020-04-23
AU2019280990A1 (en) 2021-01-28
SG11202012004SA (en) 2021-01-28
EP3802812A4 (en) 2022-03-30
CA3102779A1 (en) 2019-12-12
WO2019236982A1 (en) 2019-12-12
EP3802812A1 (en) 2021-04-14
JP2021526858A (ja) 2021-10-11
US20200071718A1 (en) 2020-03-05
KR20210058806A (ko) 2021-05-24
US10822617B2 (en) 2020-11-03
US20210047654A1 (en) 2021-02-18

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