CN112914620B - Tumor tissue sampling device based on spiral knife cutting principle - Google Patents
Tumor tissue sampling device based on spiral knife cutting principle Download PDFInfo
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- CN112914620B CN112914620B CN202110214871.3A CN202110214871A CN112914620B CN 112914620 B CN112914620 B CN 112914620B CN 202110214871 A CN202110214871 A CN 202110214871A CN 112914620 B CN112914620 B CN 112914620B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
- A61B10/0275—Pointed or sharp biopsy instruments means for severing sample with sample notch, e.g. on the side of inner stylet
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/0283—Pointed or sharp biopsy instruments with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe
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Abstract
The invention belongs to the technical field of medical instruments, and particularly relates to a tumor tissue sampling device based on a spiral knife cutting principle. The injection device comprises an injection tube, wherein the head end of the injection tube is communicated with a needle tube, a movable rod is arranged in the injection tube, and a spiral cutting knife is sleeved at the head end of the movable rod; a retaining disc is arranged at the tail end of the cutting knife on the moving rod, a screw rod is arranged at the tail end of the moving rod, a cylindrical movable ring is further arranged in the injection tube, the screw rod is in threaded connection with the inner wall of the movable ring, and the outer wall of the movable ring is movably connected with the tail end of the inner wall of the injection tube; a sample channel is arranged in the injection tube and positioned between the movable ring and the needle head tube; the sample channel is communicated with a sample outlet pipe, and the sample outlet pipe is detachably connected with a sample pipe capable of being vacuumized. The utility model discloses when the tumour tissue is shifted into the vacuum tube from the cutting knife to this device, do not contact with external environment, reduce pollution probability.
Description
Technical Field
The invention belongs to the technical field of medical instruments, and particularly relates to a tumor tissue sampling device based on a spiral knife cutting principle.
Background
Tumors are one of the major diseases that endanger human health, and are classified as benign tumors and malignant tumors. Generally, the disease location of a tumor is located in the body and requires sampling and detection to determine the disease condition. In the prior art, the tumor sampling mode mainly comprises surgical incision cutting and needle puncturing sampling. Surgical operation is needed by surgical operation cutting as the name implies, scars are left on the body surface of a patient, and if the tumor treatment process is long, multiple times of sampling are needed to be performed, so that the pain of the patient is increased, and the recovery of the wound is not facilitated. The needle puncturing sampling mainly comprises the steps of puncturing a tumor part by adopting a syringe containing a needle, sucking out part of tumor tissue by pulling a piston rod of the syringe, and finally transferring the part of tumor tissue into a sample tube to be sent to a clinical laboratory for inspection. The needle head puncture sampling wound is small, the wound is easy to recover, the needle head puncture sampling wound is suitable for patients with multiple sampling, and the defect of surgical operation cutting can be overcome. However, when the needle head puncture sampling device transfers the taken tumor tissue into the sample tube, the tumor tissue needs to be scraped by an additional device, or the puncture needle of the sampling device needs to be repeatedly scraped in the sample tube, so that the contact area of the tumor tissue and the external environment is large, and the pollution risk exists. Therefore, there is a need to develop a tumor sampling apparatus that reduces contamination.
Disclosure of Invention
In order to solve the technical problems, the invention provides a tumor tissue sampling device based on a spiral knife cutting principle.
The invention aims to provide a tumor tissue sampling device based on a spiral knife cutting principle, which comprises an injection tube, wherein the head end of the injection tube is communicated with a needle tube, a movable rod is arranged in the injection tube, a spiral cutting knife is sleeved at the head end of the movable rod, and the cutting knife can axially reciprocate along the needle tube and can penetrate out of the needle tube;
the movable ring is arranged in the injection tube, the spiral rod penetrates through and is screwed with the inner wall of the movable ring, and the outer wall of the movable ring is movably connected with the tail end of the inner wall of the injection tube;
a sample channel is arranged in the injection tube and positioned between the movable ring and the needle head tube, three openings are formed in the sample channel, and the three openings are respectively clamped with the interception disc, communicated with the needle head tube and communicated with a sample outlet tube arranged on the side wall of the injection tube; one end of the sample channel along the axial direction of the injection tube is coaxially sleeved outside the movable rod and the cutting knife;
the sampling tube is detachably connected with a sample tube capable of being vacuumized.
Preferably, the above tumor tissue sampling device based on the spiral knife cutting principle, the sample channel is in an inverted L shape, and has two openings A, B along the axial direction of the injection tube, the opening a is communicated with the needle tube, the opening B is arranged towards the spiral rod and is used for being clamped with the retaining disc, and an opening C is arranged along the axial direction perpendicular to the injection tube and is communicated with the arranged outlet tube.
Preferably, in the tumor tissue sampling device based on the spiral knife cutting principle, a compression spring is further sleeved on the periphery of the moving rod, the tail end of the compression spring is fixed on the interception disc, the cutting knife is made of compressible elastic materials, the cutting knife surrounds and is fixed on the compression spring, when the compression spring is in a natural extension state, the cutting knife is also in a natural extension state, and the moving rod is connected to the interception disc in a penetrating manner and is screwed to the interception disc.
Preferably, in the tumor tissue sampling device based on the spiral knife cutting principle, the structure of the sample channel is a tee T-shaped channel, the tee T-shaped channel comprises a vertical section and a horizontal section positioned on the vertical section, the moving rod and the cutting knife are positioned in the vertical section, and the sampling tube is communicated with an end opening of the horizontal section.
Preferably, in the tumor tissue sampling device based on the spiral knife cutting principle, the mouth of the outlet tube and the mouth of the needle tube far away from the injection tube are covered with sealing covers.
Preferably, in the tumor tissue sampling device based on the spiral knife cutting principle, the distance between the outer edge of the cutting knife and the inner wall of the needle tube is set to be 0.1-0.5mm.
Preferably, in the tumor tissue sampling device based on the spiral knife cutting principle, the vacuum tube is provided with a vacuumizing port.
Preferably, in the tumor tissue sampling device based on the spiral knife cutting principle, a handle disc is installed at the rear part of the movable ring at the tail end of the spiral rod, and a holding disc is installed at the tail end of the movable ring.
Preferably, in the tumor tissue sampling device based on the spiral knife cutting principle, two rows of pits are formed in the outer wall of the movable ring along the axial direction, elastic balls are symmetrically arranged at the tail end of the inner wall of the injection tube, and the elastic balls can be clamped in any pit at the same side of the elastic balls.
Preferably, in the tumor tissue sampling device based on the spiral knife cutting principle, the elastic ball comprises a rigid ball which is used for being clamped in the pit, and the rigid ball is connected with the inner wall of the injection tube through an elastic material plate.
Compared with the prior art, the invention has the following beneficial effects:
1. the needle tube of the invention acts as a puncture needle; the sampling amount of the spiral cutting knife is larger than that of a common straight tubular puncture needle; the tumor tissue is embedded in the spiral gap, and when the cutting knife is pulled back into the needle head pipe and the needle head pipe is pulled out through the movable ring, the tumor tissue sample separated from the machine body is not easy to fall off and fall off the needle head pipe, so that the risk that the tumor tissue sample is free in the body is avoided, and the tumor cell transfer probability is reduced. In addition, after the movable ring is arranged, the reverse spiral cutting knife is not needed, so that the times of secondary spiral cutting of tumors can be reduced, the cutting knife can be rapidly separated from tumor tissues, the pain time of a patient is reduced, and the sampling efficiency is improved.
2. According to the invention, the sample can be quickly transferred from the sample channel into the vacuum tube under the action of negative pressure by arranging the sample tube capable of being vacuumized, so that repeated scraping and transferring operation efficiency is not required. When the tumor tissue is transferred into the vacuum tube from the cutting knife, the tumor tissue is not contacted with the external environment, so that the pollution probability is reduced. The reagent which can maintain the activity of the tumor cells, such as physiological saline, is put in the vacuum tube in advance, so that the inactivation of the tumor cells in the sample transferring process is prevented, and the detection fidelity is influenced.
Drawings
FIG. 1 is a schematic diagram of a tumor tissue sampling apparatus according to the embodiment 1 of the present invention based on the principle of helical knife cutting;
FIG. 2 is a schematic view of the embodiment 1 of the present invention when the cutter passes through the needle tube;
FIG. 3 is a schematic view showing the structure of the cutter according to the embodiment 1 of the present invention when the cutter is retracted into the needle tube;
FIG. 4 is a schematic diagram of the device of example 1 of the present invention when a tumor tissue sample is metastasized;
FIG. 5 is a schematic view of the appearance structure of FIG. 2;
fig. 6 is a schematic diagram illustrating the connection between the cutter and the movable rod according to embodiment 2 of the present invention;
fig. 7 is a schematic structural diagram of embodiment 3 of the present invention.
Detailed Description
In order that those skilled in the art will better understand the technical scheme of the present invention, the present invention will be further described with reference to specific embodiments and drawings.
In the present invention, "trailing end, rear" refers to the end of the device that is held in the hand during sampling, and "leading end, front" refers to the end that is proximal to the tumor site of the patient.
Example 1
1-5, a tumor tissue sampling device based on a spiral knife cutting principle comprises a syringe 1, wherein a needle tube 2 is arranged at the head end of the syringe 1 in a communicated manner, the needle tube 2 is used for penetrating into a human body, a reasonable diameter range is selected, a movable rod 3 is arranged in the syringe 1, a spiral-shaped cutting knife 31 is sleeved at the head end of the movable rod 3, and the cutting knife 31 can reciprocate along the axial direction of the needle tube 2 and can penetrate out of the needle tube 2. The movable rod 3 is provided with a retaining disc 32 which is connected with the tail end of the cutting knife 31 in a penetrating way, and the tail end of the movable rod 3 is provided with a head end of a screw rod 33 which is coaxially arranged with the movable rod. The inside of syringe 1 still is provided with the movable ring 4 of tube-shape, and movable ring 4 and screw 33 coaxial setting, screw 33 run through and the spiro union is at movable ring 4 inner wall. The outer wall of the movable ring 4 is movably connected with the tail end of the inner wall of the injection tube 1, specifically, two rows of pits 41 are formed in the outer wall of the movable ring 4 along the axial direction, the number of the pits 41 in each row is 3-15, the tail end of the inner wall of the injection tube 1 is symmetrically provided with elastic balls 11, and the elastic balls 11 can be clamped in any pit 41 on the same side of the elastic balls. The sample channel 12 is arranged in the injection tube 1 and positioned between the movable ring 4 and the needle tube 2, three openings are respectively arranged on the sample channel 12, two openings are respectively arranged along the axial direction of the injection tube 1 and A, B, an opening A is communicated with the needle tube 2, an opening B is arranged towards the screw rod 33, and an opening C is arranged along the axial direction perpendicular to the injection tube 1 and is communicated with the side wall of the injection tube 1. One end of the sample channel 12 along the axial direction of the injection tube 1 is coaxially sleeved outside the movable rod 3 and the cutting knife 31, the movable rod 3 and the cutting knife 31 at the periphery thereof can reciprocate along the sample channel 12, and the interception disc 32 can be embedded into the opening B of the sample channel 12 and seal the opening B. The opening C of the sample channel 12 is communicated with a sampling tube 13 arranged on the outer side wall of the injection tube 1, and sealing covers are covered on the opening of the sampling tube 13 and the opening of the needle head tube 2 far away from the injection tube 1.
In this embodiment, the elastic ball 11 includes a rigid ball, such as a rigid metal ball or a rigid plastic ball, which is clamped in the recess 41, and is connected with the inner wall of the syringe 1 through an elastic material plate, and when the movable ring 4 and the elastic material plate are made of materials, it should be ensured that the elastic material plate can be deformed by the hand force of a person, but the elastic material plate cannot be deformed by the gravity of the movable ring 4.
In this embodiment, the sample channel 12 has an inverted L shape, with two ends of its vertical end corresponding to the openings A and B, respectively, and with its horizontal end corresponding to the opening C.
The sampling working principle of the device is as follows: in the initial state, see fig. 1, the cutter 31 is positioned inside the needle tube 2, most of the movable ring 4 is positioned inside the syringe 1, the interception disk 32 is separated from the sample channel 12, and is positioned in the opening of the sample channel 12. During sampling, the needle tube 2 acts as a puncture needle, the sealing cover on the needle tube 2 is removed, the needle tube 2 is punctured into the tumor part of a patient, and the needle tube 2 can be made of metal materials. The injection tube 1, the needle tube 2, the movable rod 3, the cutting knife 31, the screw rod 33 and the movable ring 4 are coaxially arranged; the manual rotation screw 33 is rotated in the direction of the needle tube 2, so that the cutter 31 protrudes outside the needle tube 2, see fig. 2; the rotary screw rod 33 drives the moving rod 3 and the cutting knife 31 to rotate in sequence, so that the cutting knife 31 performs rotary cutting and sampling on tumors, and tumor tissues are left in the screw gaps of the cutting knife 31; then the movable ring 4 is pulled towards the tail end of the injection tube 1, and then the movable rod 3 and the cutting knife 31 are sequentially driven to return into the needle tube 2, see fig. 3, and the needle tube 2 is pulled out of the patient body at the moment, so that the sampling process is completed. The spiral cutting knife 31 provided by the invention has a sampling amount larger than that of a common straight tubular puncture needle, and because tumor tissues are embedded in a spiral gap, when the cutting knife 31 is pulled back into the needle head pipe 2 and the needle head pipe 2 is pulled out by the movable ring 4, a tumor tissue sample separated from a machine body is not easy to fall off and fall off the needle head pipe 2, so that the risk that the tumor tissue sample is free in the body is avoided, and the tumor cell transfer probability is reduced. In addition, after the movable ring 4 is arranged, the reverse spiral cutter 31 is not needed, so that the times of secondarily spirally cutting tumors can be reduced, the cutter 31 can be rapidly separated from tumor tissues, the pain time of a patient is reduced, and the sampling efficiency is improved.
Preferably, in order to further prevent the tumor tissue sample that has been detached from remaining in the body, the distance between the outer edge of the cutter 31 and the inner wall of the needle tube 2 is set to 0.1-0.5mm.
The sample transfer working principle of the device is as follows: after the device is detached, the screw 33 is screwed towards the tail end of the injection tube 1, so that the interception disc 32 is embedded into the opening B at the tail end of the vertical end of the sample channel 12, and the opening B is sealed, and at the moment, only two openings A and C are left in the sample channel 12. The sealing cover covered on the sampling tube 13 is taken down, the sampling tube 13 is inserted into the vacuum sample tube 5, and referring to fig. 4, under the action of negative pressure, the sample is rapidly transferred into the vacuum tube 5 from the sample channel 12, and the efficiency of repeated scraping and transferring operations is high. When the tumor tissue is transferred into the vacuum tube 5 from the device, the tumor tissue is not contacted with the external environment, so that the pollution probability is reduced.
Preferably, a reagent capable of maintaining the activity of tumor cells, such as physiological saline, is pre-placed in the vacuum tube 5 to prevent the inactivation of tumor cells during the sample transfer process, thereby affecting the detection fidelity.
Preferably, the vacuum tube 5 is provided with a vacuum-pumping port 51, and the vacuum pump can be communicated with the vacuum-pumping port 51 to pump tumor tissue samples so as to improve the sample transfer efficiency.
Preferably, the tail end of the screw rod 33 is provided with a handle disc 34 at the rear part of the movable ring 4, a holding disc 42 is arranged between the movable ring 4 and the handle disc 34, and the handle disc 34 is held by hand to rotate the screw rod 33 or the holding disc 42 to pull the movable ring 4, so that the holding power is high and the force is easy to use.
Example 2
The tumor tissue sampling device based on the spiral knife cutting principle is basically the same as the structure of the embodiment 1, except that referring to fig. 6, the outer circumference of the moving rod 3 is further sleeved with a compression spring 35, the tail end of the compression spring 35 is fixed on the retaining disc 32, the cutting knife 31 is made of a compressible elastic material, the cutting knife 31 surrounds and is fixed on the compression spring 35, and when the compression spring 34 is in a natural extension state, the cutting knife 31 is also in a natural extension state. The catch tray 32 can be snapped into the opening B of the sample channel 12, and the moving rod 3 is threaded and screwed onto the catch tray 32. When the movable rod 3 is pulled towards the tail end of the injection tube 1, the interception disc 32 is clamped in the opening B of the sample channel 12, the movable rod 3 is driven to rotate by rotating the spiral rod 33, the cutting knife 31 and the compression spring 34 are gradually compressed under the blocking of the interception disc 32, and tumor tissues in the gap of the cutting knife 31 are extruded into the horizontal end opening C of the sample channel 12 in the compression process, so that the tumor tissues are convenient to transfer. With the structure of this embodiment, the engagement resistance of the catch tray 32 with the opening B of the sample channel 12 is greater than the force required to rotate the movable rod 3 around the catch tray 32.
Example 3
A tumor tissue sampling device based on the spiral knife cutting principle is basically the same as the structure of embodiment 1, except that, in order to further improve the transfer efficiency, referring to fig. 7, the structure of the sample channel 12 is configured as a tee-shaped channel, including a vertical section and a horizontal section located at the midpoint of the vertical section, then the distances from the two ends of the vertical section to the ends of the horizontal section are equal, the cutter 31 is located in the vertical section of the tee-shaped channel, the vertical section has two openings, which are respectively equivalent to the function of the opening A, B of embodiment 1, the horizontal section has an opening, which is equivalent to the function of the opening C of embodiment 1, the sample outlet tube 13 is communicated with the end opening of the horizontal section of the sample channel 12, the length of the cutter 31 is equal to the length of the vertical end of the sample channel 12, and when the interception disc 32 is embedded in the tail end opening of the vertical end of the sample channel 12, the horizontal end of the sample channel 12 corresponds to the midpoint of the cutter 31, and then the tumor sample can be rapidly converged into the vacuum tube 5 in a bidirectional manner.
It should be noted that, the connection relationships of the components not specifically mentioned in the present invention are all default to the prior art, and the connection relationships of the structures are not described in detail because they do not relate to the invention points and are common applications of the prior art.
It should be noted that, when numerical ranges are referred to in the present invention, it should be understood that two endpoints of each numerical range and any numerical value between the two endpoints are optional, and because the adopted step method is the same as the embodiment, in order to prevent redundancy, the present invention describes a preferred embodiment. While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. It is therefore intended that the following claims be interpreted as including the preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (7)
1. The tumor tissue sampling device based on the spiral knife cutting principle is characterized by comprising an injection tube (1), wherein a needle tube (2) is arranged at the head end of the injection tube (1) in a communicating manner, a movable rod (3) is arranged in the injection tube, a spiral-shaped cutting knife (31) is sleeved at the head end of the movable rod (3), and the cutting knife (31) can axially reciprocate along the needle tube (2) and can penetrate out of the needle tube (2);
the movable rod (3) is positioned at the tail end of the cutting knife (31) in a penetrating way, a interception disc (32) is arranged at the tail end of the movable rod (3), the head end of a spiral rod (33) coaxially arranged with the movable rod is arranged at the tail end of the movable rod, a cylindrical movable ring (4) is further arranged in the injection tube (1), the spiral rod (33) penetrates through and is in threaded connection with the inner wall of the movable ring (4), and the outer wall of the movable ring (4) is movably connected with the tail end of the inner wall of the injection tube (1);
a sample channel (12) is arranged in the injection tube (1) and between the movable ring (4) and the needle tube (2), three openings are formed in the sample channel (12), and the three openings are respectively clamped with the interception disc (32), communicated with the needle tube (2) and communicated with a sampling tube (13) arranged on the side wall of the injection tube (1); one end of the sample channel (12) along the axial direction of the injection tube (1) is coaxially sleeved outside the movable rod (3) and the cutting knife (31);
the sampling tube (13) is detachably connected with a sample tube capable of being vacuumized;
the periphery of the movable rod (3) is also sleeved with a compression spring (35), the tail end of the compression spring (35) is fixed on the interception disc (32), the cutting knife (31) is made of compressible elastic materials, the cutting knife (31) surrounds and is fixed on the compression spring (35), when the compression spring (35) is in a natural extension state, the cutting knife (31) is also in a natural extension state, and the movable rod (3) is connected to the interception disc (32) in a penetrating and threaded manner;
two rows of pits (41) are formed in the outer wall of the movable ring (4) along the axial direction, elastic balls (11) are symmetrically arranged at the tail end of the inner wall of the injection tube (1), and the elastic balls (11) can be clamped in any pit (41) on the same side of the elastic balls;
the elastic ball (11) comprises a rigid ball which is used for being clamped in the concave pit (41), and the rigid ball is connected with the inner wall of the injection tube (1) through an elastic material plate.
2. The tumor tissue sampling device based on the spiral knife cutting principle according to claim 1, wherein the sample channel (12) is in an inverted L shape, and has two openings, A, B respectively, along the axial direction of the injection tube (1), the opening a is communicated with the needle tube (2), the opening B is arranged towards the spiral rod (33) and is used for being clamped with the interception disc (32), and an opening C is arranged along the axial direction perpendicular to the injection tube (1) and is communicated with the arranged outlet tube (13).
3. Tumor tissue sampling device based on the principle of helical knife cutting according to claim 1, characterized in that the structure of the sample channel (12) is provided as a tee-shaped channel comprising a vertical section and a horizontal section on the vertical section, the moving rod (3) and the cutting knife (31) are located in the vertical section, the sampling tube (13) is in open communication with the end of the horizontal section.
4. A tumor tissue sampling device based on the principle of helical blade cutting according to any one of claims 1-3, characterized in that the mouth of the outlet tube (13) and the needle tube (2) remote from the injection tube (1) are both covered with sealing caps.
5. The tumor tissue sampling apparatus based on the spiral knife cutting principle according to claim 4, wherein the distance between the outer edge of the cutting knife (31) and the inner wall of the needle tube (2) is set to 0.1-0.5mm.
6. The tumor tissue sampling apparatus based on the spiral knife cutting principle according to claim 4, wherein a vacuum suction port (51) is provided on the vacuum tube (5).
7. The tumor tissue sampling device based on the spiral knife cutting principle according to claim 4, wherein a handle disc (34) is mounted at the rear of the movable ring (4) at the tail end of the spiral rod (33), and a holding disc (42) is mounted at the tail end of the movable ring (4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN202110214871.3A CN112914620B (en) | 2021-02-23 | 2021-02-23 | Tumor tissue sampling device based on spiral knife cutting principle |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110214871.3A CN112914620B (en) | 2021-02-23 | 2021-02-23 | Tumor tissue sampling device based on spiral knife cutting principle |
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| CN112914620A CN112914620A (en) | 2021-06-08 |
| CN112914620B true CN112914620B (en) | 2023-08-29 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US10299819B2 (en) * | 2016-07-28 | 2019-05-28 | Covidien Lp | Reciprocating rotary surgical cutting device and system for tissue resecting, and method for its use |
| CN206534663U (en) * | 2016-08-31 | 2017-10-03 | 陈世辉 | Spiral soft tissue biopsy needle |
| CN107928714A (en) * | 2017-12-29 | 2018-04-20 | 南通霆川电子科技有限公司 | A kind of tumor sampling device |
| CN211674354U (en) * | 2019-07-24 | 2020-10-16 | 孙兴伟 | Tumor tissue biopsy puncture sampling device |
| CN210843196U (en) * | 2019-09-30 | 2020-06-26 | 山东卫康医学检验有限公司 | Tumor gene detection sampling device |
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