CN112903878A - Headspace sampling device for medicine inspection - Google Patents
Headspace sampling device for medicine inspection Download PDFInfo
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- CN112903878A CN112903878A CN202110150775.7A CN202110150775A CN112903878A CN 112903878 A CN112903878 A CN 112903878A CN 202110150775 A CN202110150775 A CN 202110150775A CN 112903878 A CN112903878 A CN 112903878A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
- G01N2001/1418—Depression, aspiration
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
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- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Hydrology & Water Resources (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention relates to the technical field of medicine detection, in particular to a headspace sampling device for medicine inspection, which comprises a base and a top plate in a U-shaped structure, wherein the top plate is positioned above the base, two support columns are connected between two sides of the bottom of the top plate and the upper surface of the base, an installation plate is arranged on the upper surface of the base, a plurality of installation holes are formed in the installation plate, sample bottles are embedded in the installation holes, a fixing mechanism for fixing the sample bottles is arranged on the installation plate, the fixing mechanism comprises movable grooves formed in two sides of the installation holes, movable blocks are arranged in the movable grooves, elastic pieces are arranged on the sides of the movable blocks, which are far away from the sample bottles, one sides of the tops of the movable blocks are in an inclined plane structure, and rubber pads are arranged on the sides, which are attached to the sample bottles, of a current sampling needle, when the sampling needle cannot, the sampling needle can contact with the bottle cap, so that the sampling needle is bent, and the subsequent detection of the sample is influenced.
Description
Technical Field
The invention relates to the technical field of medicine inspection, in particular to a headspace sampling device for medicine inspection.
Background
The headspace sampling is a commonly used sampling mode in a gas chromatography detection method, and the headspace sampling is generally carried out by precisely weighing 3-5ml of each of a standard solution and a test sample solution and placing the standard solution and the test sample solution into headspace sampling bottles with the volume of 8ml respectively. Heating each sample bottle in a water bath for 30-40min to ensure that residual solvent is volatilized to reach saturation, and then extracting a proper amount of headspace air by using an injector heated in an empty test tube in the same water bath, but at present, whatever heating mode is adopted, the sample bottles are heated, the detection time of a gas chromatograph is longer, and generally, after a program is set, the samples are placed well, and the detection results can be recorded after the detection is completely finished.
When the current sampling needle can not aim at the sealing gasket at the upper opening of the bottle cap of the sample bottle 3 when sampling the sample bottle, the sampling needle can contact with the bottle cap to bend the sampling needle, so that the follow-up detection of the sample is influenced, and therefore, the headspace sampling device for medicine inspection is provided to well solve the defects.
Disclosure of Invention
The invention aims to provide a headspace sampling device for drug inspection.
In order to achieve the purpose, the invention provides the following technical scheme: a headspace sampling device for drug testing comprises a base and a top plate in a U-shaped structure, wherein the top plate is positioned above the base, two support columns are connected between two sides of the bottom of the top plate and the upper surface of the base, a mounting plate is arranged on the upper surface of the base, a plurality of mounting holes are formed in the mounting plate, sample bottles are embedded in the mounting holes, a fixing mechanism for fixing the sample bottles is arranged on the mounting plate, the fixing mechanism comprises movable grooves formed in two sides of the mounting holes, movable blocks are arranged in the movable grooves, elastic pieces are arranged on one sides of the movable blocks, which are far away from the sample bottles, one sides of the tops of the movable blocks are in an inclined plane structure, rubber pads are arranged on one sides of the movable blocks, which are attached to the sample bottles, a magnetic shaft is arranged on the inner side of the top plate, and a linear motor is arranged, linear motor bottom fixed mounting has electric putter, electric putter output fixedly connected with pipette, the pipette bottom is provided with the sampling needle, the roof top be provided with time control switch and the controller that linear motor and electric putter electricity are connected, time control switch and controller control jointly linear motor moving direction and the distance of removal, roof top fixed mounting has the heating bucket, the positive fixed mounting of heating bucket has the liquid pump, the liquid pump outlet end with the inside intercommunication of heating bucket, the end of intaking of liquid pump with be connected with communicating pipe between the pipette.
Furthermore, the elastic part is a spring, and two ends of the elastic part are respectively abutted against the inner end face of the movable groove and the movable block.
Furthermore, the movable groove with the movable block is the protruding style of calligraphy column structure, for the embedding in the mounting hole during the sample bottle, the movable block is provided with the one end of rubber pad and extends to in the mounting hole.
Further, heating barrel head portion is provided with the hot plate, the hot plate with the controller electricity is connected, heating barrel head portion is provided with the inlet pipe, the heating barrel lateral wall is provided with row's material pipe, all be provided with the valve on inlet pipe and the row's material pipe.
Furthermore, a temperature sensor electrically connected with the controller is arranged at the top end inside the heating barrel.
Furthermore, the controller, the linear motor, the electric push rod, the liquid pump and the time control switch are electrically connected with an external power supply through leads.
Compared with the prior art, the invention has the beneficial effects that:
1. this kind of headspace sampling device for medicine inspection, through setting up the mounting panel, and set up a plurality of mounting hole on the mounting panel, set up the movable groove in the mounting hole simultaneously, the movable block, rubber pad and elastic component, when fixing the sample bottle, can fix in the direct insertion mounting hole of sample bottle bottom, when inserting the mounting hole, because movable block top one side is the inclined plane structure, make the sample bottle can promote the movable block and remove to the movable groove, after the bottom contact of sample bottle bottom and mounting hole, two movable blocks centre gripping in the both sides of sample bottle this moment, the setting of rubber pad can prevent sample bottle wearing and tearing, the life of extension sample bottle, the sampling device who has this structure, can fix the sample bottle fast, and sampling efficiency is improved.
2. This kind of headspace sampling device is used in medicine inspection, through setting up the magnetic axis, linear electric motor, electric putter, controller and time switch, the distance of time switch and the steerable linear electric motor of controller along the trend of magnetic axis and removal at every turn, thereby make the sample needle of pipette bottom can both be located the sample bottle directly over at every turn, solve present sample needle when can not aim at the sealed pad of the bottle lid upper shed department of sample bottle when taking a sample to the sample bottle, thereby the sample needle can take place to contact with the bottle lid and make the sample needle crooked, thereby influence the problem of follow-up detection to the sample.
3. This kind of headspace sampling device is used in medicine inspection, through setting up the heating barrel, temperature sensor, liquid pump and communicating pipe, during the sample, insert pipette and sample needle downstream with controller control electric putter and take a sample in the sample bottle, then take out the liquid in the pipette to the heating barrel in through the liquid pump and heat, temperature sensor can the temperature in the real-time detection heating barrel, the control hot plate carries out the rational heating to the liquid of heating barrel, make liquid reach the optimum temperature, then carry out the analysis and reach the result in sending into gas chromatography appearance with gas through the carrier gas.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is an enlarged schematic view of FIG. 1 at A in accordance with the present invention;
FIG. 3 is an enlarged view of FIG. 1 at B of the present invention;
in the figure: 1. the base, 2, the roof, 3, the support column, 4, the mounting panel, 5, the mounting hole, 6, the sample bottle, 7, the activity groove, 8, the movable block, 9, the spring part, 10, the rubber pad, 11, the magnetic axis, 12, linear motor, 13, electric putter, 14, the pipette, 15, the sample needle, 16, time switch, 17, the controller, 18, the heating bucket, 19, the liquid pump, 20, communicating pipe, 21, the hot plate, 22, the inlet pipe, 23, arrange the material pipe, 24, temperature sensor.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention.
Referring to fig. 1 and 3, the present embodiment provides a technical solution: a headspace sampling device for drug testing comprises a base 1 and a top plate 2 in a U-shaped structure, wherein the top plate 2 is positioned above the base 1, two support columns 3 are connected between two sides of the bottom of the top plate 2 and the upper surface of the base 1, a mounting plate 4 is arranged on the upper surface of the base 1, a plurality of mounting holes 5 are arranged on the mounting plate 4, sample bottles 6 are embedded in the mounting holes 5, a fixing mechanism for fixing the sample bottles 6 is arranged on the mounting plate 4, the fixing mechanism comprises movable grooves 7 arranged on two sides of the mounting holes 5, movable blocks 8 are arranged in the movable grooves 7, the movable grooves 7 and the movable blocks 8 are both in a convex structure, when the sample bottles 6 are embedded in the mounting holes 5, one ends of the movable blocks 8, which are provided with rubber pads 10, extend into the mounting holes 5, elastic pieces 9 are arranged on one sides of the movable blocks 8, which are far away from the sample bottles 6, the elastic pieces 9 are springs, two ends of the elastic pieces 9 are respectively abutted, 8 top one sides of movable block are the inclined plane structure, 8 one sides of laminating mutually with sample bottle 6 of movable block are provided with rubber pad 10, when fixing sample bottle 6, can fix in 6 bottom disect insertions mounting holes 5 of sample bottle, when inserting mounting hole 5, because 2 top one sides of movable block are the inclined plane structure, make sample bottle 6 can promote movable block 8 and remove to activity inslot 7, after 6 bottoms of sample bottle contact with mounting hole 5, two 8 centre gripping in the both sides of sample bottle 6 of movable block this moment, rubber pad 10 set up and can prevent sample bottle 6 wearing and tearing, prolong sample bottle 6's life, the sampling device who has this structure, can fix sample bottle 6 fast, the sampling efficiency is improved.
Wherein, the inner side of the top plate 2 is provided with a magnetic shaft 11, the magnetic shaft 11 is provided with a linear motor 12 in a sliding manner, the bottom of the linear motor 12 is fixedly provided with an electric push rod 13, the output end of the electric push rod 13 is fixedly connected with a pipette 14, the bottom of the pipette 14 is provided with a sampling needle 15, the top of the top plate 2 is provided with a time switch 16 and a controller 17 which are electrically connected with the linear motor 12 and the electric push rod 13, the time switch 16 and the controller 17 jointly control the moving direction and the moving distance of the linear motor 12, the top of the top plate 2 is fixedly provided with a heating barrel 18, the front of the heating barrel 18 is fixedly provided with a liquid pump 19, the water outlet end of the liquid pump 19 is communicated with the inside of the heating barrel 18, a communicating pipe 20 is connected between the water inlet end of the liquid pump 19 and the pipette 14, the time switch 16 and the controller 17 can control the moving direction and, the problem of present sampling needle 15 can not aim at the sealed pad of the bottle lid upper shed department of sample bottle 6 when taking a sample to sample bottle 6 is solved, thereby sampling needle 15 can take place to contact with the bottle lid and make sampling needle 15 crooked to influence follow-up detection to the sample is solved.
Wherein, heating barrel 18 bottom is provided with hot plate 21, hot plate 21 is connected with controller 17 electricity, heating barrel 18 top is provided with inlet pipe 22, heating barrel 18 lateral wall is provided with row material pipe 23, all be provided with the valve on inlet pipe 22 and the row material pipe 23, heating barrel 18 inside top is provided with temperature sensor 24 with controller 17 electricity is connected, it takes a sample to move downwards with pipette 14 and sample needle 15 through controller 17 control electric putter 13 and insert in sample bottle 6, then heat in taking out heating barrel 18 through liquid pump 19 with the liquid in pipette 14, temperature sensor 24 can real-time detection heating barrel 18 in the temperature, control hot plate 21 carries out reasonable heating to heating barrel 18's liquid, make liquid reach the optimum temperature, then send into gaseous analysis and drawing the result in the gas chromatograph through the carrier gas.
The controller 17, the linear motor 12, the electric push rod 13, the liquid pump 19 and the time control switch 16 are electrically connected with an external power supply through wires.
The working principle is as follows: firstly, the bottom end of a sample bottle 6 can be directly inserted into a mounting hole 5 to be fixed, when the sample bottle is inserted into the mounting hole 5, the sample bottle 6 can push the movable block 8 to move into the movable groove 7 because one side of the top of the movable block 2 is of an inclined plane structure, when the bottom of the sample bottle 6 is contacted with the bottom of the mounting hole 5, the two movable blocks 8 are clamped at two sides of the sample bottle 6 at the moment, the rubber pad 10 is arranged to prevent the sample bottle 6 from being worn, the service life of the sample bottle 6 is prolonged, then, the trend of the linear motor 12 along the magnetic shaft 11 and the distance of each movement are controlled by the time control switch 16 and the controller 17, when the linear motor 12 stops, the controller 17 controls the electric push rod 13 to move the pipette 14 and the sampling needle 15 downwards to be inserted into the sample bottle 6 for sampling, then the liquid in the pipette 14 is pumped into the heating barrel 18 by the liquid pump 19 for heating, the temperature sensor 24 can detect the, the heating plate 21 is controlled to reasonably heat the liquid in the heating barrel 18 to enable the liquid to reach the optimal temperature, and then the gas is sent into a gas chromatograph for analysis through the carrier gas, and the result is obtained.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. The utility model provides a medicine inspection is with headspace sampling device, includes base (1) and roof (2) that are U type structure, its characterized in that: the sample bottle fixing device is characterized in that the top plate (2) is located above the base (1), two supporting columns (3) are connected between the two sides of the bottom of the top plate (2) and the upper surface of the base (1), a mounting plate (4) is arranged on the upper surface of the base (1), a plurality of mounting holes (5) are formed in the mounting plate (4), sample bottles (6) are embedded in the mounting holes (5), a fixing mechanism for fixing the sample bottles (6) is arranged on the mounting plate (4), the fixing mechanism comprises movable grooves (7) formed in the two sides of the mounting holes (5), movable blocks (8) are arranged in the movable grooves (7), elastic pieces (9) are arranged on one sides, far away from the sample bottles (6), of the movable blocks (8), one sides of the tops of the movable blocks (8) are of inclined plane structures, rubber pads (10) are arranged on one sides, attached to the sample bottles (6), of the movable blocks (8), the inner side of the top plate (2) is provided with a magnetic shaft (11), the magnetic shaft (11) is provided with a linear motor (12) in a sliding manner, the bottom of the linear motor (12) is fixedly provided with an electric push rod (13), the output end of the electric push rod (13) is fixedly connected with a liquid suction pipe (14), the bottom of the liquid suction pipe (14) is provided with a sampling needle (15), the top of the top plate (2) is provided with a time switch (16) and a controller (17) which are electrically connected with the linear motor (12) and the electric push rod (13), the time switch (16) and the controller (17) jointly control the moving direction and the moving distance of the linear motor (12), the top of the top plate (2) is fixedly provided with a heating barrel (18), the front of the heating barrel (18) is fixedly provided with a liquid pump (19), and the water outlet end of the liquid pump (19, a communicating pipe (20) is connected between the water inlet end of the liquid pump (19) and the liquid suction pipe (14).
2. A headspace sampling device for pharmaceutical testing according to claim 1, wherein: the elastic piece (9) is a spring, and two ends of the elastic piece (9) are respectively abutted against the inner end face of the movable groove (7) and the movable block (8).
3. A headspace sampling device for pharmaceutical testing according to claim 1, wherein: the movable groove (7) and the movable block (8) are both in a convex structure, the sample bottle (6) is embedded into the mounting hole (5), and one end of the movable block (8) provided with a rubber pad (10) extends into the mounting hole (5).
4. A headspace sampling device for pharmaceutical testing according to claim 1, wherein: heating bucket (18) bottom is provided with hot plate (21), hot plate (21) with controller (17) electricity is connected, heating bucket (18) top is provided with inlet pipe (22), heating bucket (18) lateral wall is provided with row material pipe (23), all be provided with the valve on inlet pipe (22) and row material pipe (23).
5. A headspace sampling device for pharmaceutical testing according to claim 1, wherein: and a temperature sensor (24) electrically connected with the controller (17) is arranged at the top end in the heating barrel (18).
6. A headspace sampling device for pharmaceutical testing according to claim 1, wherein: the controller (17), the linear motor (12), the electric push rod (13), the liquid pump (19) and the time control switch (16) are electrically connected with an external power supply through leads.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110150775.7A CN112903878A (en) | 2021-02-04 | 2021-02-04 | Headspace sampling device for medicine inspection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110150775.7A CN112903878A (en) | 2021-02-04 | 2021-02-04 | Headspace sampling device for medicine inspection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112903878A true CN112903878A (en) | 2021-06-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110150775.7A Withdrawn CN112903878A (en) | 2021-02-04 | 2021-02-04 | Headspace sampling device for medicine inspection |
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| Country | Link |
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| CN (1) | CN112903878A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115184494A (en) * | 2022-07-08 | 2022-10-14 | 谱质分析检测技术(上海)有限公司 | Automatic headspace sample injector |
-
2021
- 2021-02-04 CN CN202110150775.7A patent/CN112903878A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115184494A (en) * | 2022-07-08 | 2022-10-14 | 谱质分析检测技术(上海)有限公司 | Automatic headspace sample injector |
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Application publication date: 20210604 |
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| WW01 | Invention patent application withdrawn after publication |