CN112890882A - Injection device and silica gel filling equipment - Google Patents
Injection device and silica gel filling equipment Download PDFInfo
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- CN112890882A CN112890882A CN202110114213.7A CN202110114213A CN112890882A CN 112890882 A CN112890882 A CN 112890882A CN 202110114213 A CN202110114213 A CN 202110114213A CN 112890882 A CN112890882 A CN 112890882A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00792—Plastic surgery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
Abstract
The invention discloses an injection device, which comprises an injection tube body and an injection rod, wherein the injection tube body comprises a first opening end, a second opening end and a cavity, and the cavity is positioned between the first opening end and the second opening end; two ends of the injection rod are respectively a contact end and a pushing end, the contact end is inserted into the cavity through the second port, and a sealing element is further arranged on the contact end; the first opening end is provided with a convex extrusion port, the convex extrusion port is provided with a sealing plug, the center of the sealing plug is provided with a groove, and the sealing plug is detachably connected with the convex extrusion port through the groove; a filter screen is also arranged on the wall of the cavity between the convex extrusion port and the sealing element; the inner wall of cavity, the inner wall of protruding type extrusion mouth, the surface of closing plug, the surface of recess and the surface of filter screen all are provided with antibacterial material layer, can solve current silica gel filling equipment and all be disposable in order to avoid bacterial infection and caused the extravagant problem of a large amount of materials.
Description
Technical Field
The invention relates to the field of injection devices, in particular to an injection device and silica gel filling equipment.
Background
The medical solid silica gel has good biocompatibility, and is widely applied to the medical field, particularly the plastic and cosmetic medical field for more than half a century. However, the existing solid silica gel materials are all blocky, the steps of incision and stripping to form lacuna, silica gel prosthesis implantation, position adjustment, wound suturing and the like are needed in the operation, the operation wound is large, a long recovery period is needed after the operation, and the adjustment cannot be realized in the later period. And the liquid silica gel is easy to displace after injection, has large risk of generating complications such as granuloma and the like, and has large difficulty in removal. At present, the filling materials are required to be injected and repaired repeatedly, and the filling parts are deformed to different degrees, so that the physical and mental of a patient suffer from a plurality of pains, and the economic burden is increased. By miniaturizing the medical solid silica gel, the medical solid silica gel has good biocompatibility, can relieve the pain of patients and can realize continuous repair. The existing silica gel filling equipment is disposable in order to avoid bacterial infection, so that a large amount of materials are wasted, however, most of the existing antibacterial coatings can damage the safety of human bodies, and the antibacterial effect is not enough, so that the improvement is needed.
Disclosure of Invention
In view of the above problems, the present invention provides an injection device and a silica gel filling apparatus, which improve the disadvantages of the prior art, prevent silica gel particles from blocking an injection port, achieve uniform output of silica gel particles, avoid structural damage to silica gel particles, have an antibacterial effect, and can be used for multiple times.
The purpose of the invention is realized by adopting the following technical scheme:
in a first aspect, the present invention provides an injection device comprising an injection tube body and an injection rod, the injection tube body comprising a first open end, a second open end and a cavity, the cavity being located between the first open end and the second open end; the two ends of the injection rod are respectively provided with a contact end and a pushing end, the contact end is inserted into the cavity through the second port, the contact end is also provided with a sealing element, the sealing element is tightly attached to the inner wall of the cavity and can slide in the cavity, and the pushing end is arranged on the outer side of the cavity; the first opening end is provided with a convex extrusion port, the convex extrusion port is provided with a sealing plug, the center of the sealing plug is provided with a groove, and the sealing plug is detachably connected with the convex extrusion port through the groove; a filter screen is also arranged on the wall of the cavity between the convex extrusion port and the sealing element; the inner wall of the cavity, the inner wall of the convex extrusion opening, the surface of the sealing plug, the surface of the groove and the surface of the filter screen are all provided with antibacterial material layers.
Preferably, two sides of the second opening end are provided with force-borrowing plates, and the force-borrowing plates are perpendicular to the injection tube body.
Preferably, the injection tube body is made of a high polymer polypropylene material, and the injection rod is made of a high polymer polyvinyl chloride material.
Preferably, the material of the sealing element is soft food-grade rubber.
Preferably, the antibacterial material layer is food-grade resin added with an antibacterial factor, wherein the antibacterial factor is a porous polyethylene oxide microsphere compounded with chitosan and dehydroabietylamine.
Preferably, the food grade resin is one of unsaturated polyester resin, vinyl resin, epoxy resin and polyurethane.
Preferably, the mass ratio of the antibacterial factor to the food-grade resin is 1: 15-50.
Preferably, the preparation method of the porous polyethylene oxide microsphere compounded with chitosan and dehydroabietylamine comprises the following steps:
(1) weighing polyethylene oxide, adding the polyethylene oxide into distilled water, placing the mixture in a water bath at the temperature of 70-90 ℃, and stirring the mixture until the polyethylene oxide is completely dissolved to obtain a polyethylene oxide solution; weighing chitosan and dehydroabietylamine, adding the chitosan and dehydroabietylamine into a polyethylene oxide solution, stirring for 0.2-0.5 h under the condition of water bath at 70-90 ℃, dropwise adding a sulfuric acid solution with the mass fraction of 40-60%, and continuously stirring for 0.5-1 h to obtain a polyethylene oxide mixed solution;
wherein the mass ratio of the polyethylene oxide to the distilled water is 1: 12-20; the mass ratio of the chitosan to the dehydroabietylamine to the polyethylene oxide solution is 2-5: 3-6: 18-25;
(2) putting dry ice into a vacuum flask, adding chloroform when the temperature in the vacuum flask is lower than 0 ℃, and adding the dry ice until the temperature in the vacuum flask is lower than-20 ℃ after the chloroform is completely added to obtain an ultra-low-temperature flowable dry ice-chloroform bath;
wherein the mass ratio of the dry ice to the chloroform in the dry ice-chloroform bath is 1.8-2.7: 2.2-3.6;
(3) and filling the polyethylene oxide mixed solution into an injector while the polyethylene oxide mixed solution is hot, dripping the polyethylene oxide mixed solution into a dry ice-chloroform bath through a needle with the diameter of 300-1000 mu m at the speed of 5-8 seconds per drop, collecting ice beads deposited at the bottom of the heat preservation bottle after dripping, quickly placing the ice beads into a drying box for freeze drying, then washing the ice beads for 3 times by using pure water, and placing the ice beads into the drying box at the temperature of 50-70 ℃ for reduced pressure drying to obtain the porous polyethylene oxide microspheres compounded with chitosan and dehydroabietylamine.
In a second aspect, the present invention also provides a silica gel filling apparatus comprising the above-mentioned injection device, which has all the functions of the injection device.
The invention has the beneficial effects that:
1. the invention provides an injection device and silica gel filling equipment, wherein the injection device can be movably arranged in a cavity through an injection rod, so that silica gel particles accommodated in the cavity can flow out through a convex extrusion port arranged on a first opening end, a filter screen is also arranged between the convex extrusion port and a sealing plug, the silica gel particles can be further filtered and intercepted, the safety is ensured, and meanwhile, the uniform output of the silica gel particles can be realized. In addition, all be provided with the antibacterial material layer on the inner wall of cavity, the inner wall of protruding type extrusion mouth, the surface of closing the stopper, the surface and the filter screen of recess, can solve current silica gel filling equipment and avoid bacterial infection all be disposable and caused the extravagant problem of a large amount of materials.
2. The antibacterial factor prepared by the invention is added into the food-grade resin to form an antibacterial material layer, and the antibacterial factor and the food-grade resin are both safe and environment-friendly materials and have no toxic or side effect on human bodies. The antibacterial factor is a porous polyethylene oxide microsphere compounded with chitosan and dehydroabietylamine, the porous microsphere is prepared by taking polyethylene oxide as a carrier and taking chitosan and quaternary ammonium raw materials dehydroabietylamine as receptors, and the antibacterial factor is reacted and combined with the chitosan and dehydroabietylamine with strong antibacterial effect by a special method, so that the antibacterial factor can be uniformly adsorbed on the surface of the polyethylene oxide, a porous microsphere structure with larger surface activity is formed in the preparation process, and the antibacterial factor can play a stronger antibacterial effect after being combined with resin, so that the inside of an injection device can be free from bacterial invasion for a long time, the antibacterial effect is excellent, and no toxic or side effect is caused to a human body.
Drawings
The invention is further illustrated by means of the attached drawings, but the embodiments in the drawings do not constitute any limitation to the invention, and for a person skilled in the art, other drawings can be obtained on the basis of the following drawings without inventive effort.
Fig. 1 is a schematic view of the structure of an injection device of the present invention.
Reference numerals: the injection device comprises an injection tube body 1, an injection rod 2, a first opening end 3, a second opening end 4, a cavity 5, a convex extrusion opening 6, a closing plug 7, a force-bearing plate 8, a groove 9, a filter screen 11, a contact end 21, a pushing end 22 and a sealing piece 23.
Detailed Description
The invention is further described with reference to the following examples.
Example 1
An injection device, as shown in fig. 1, comprises an injection tube body 1 and an injection rod 2, wherein the injection tube body 1 comprises a first open end 3, a second open end 4 and a cavity 5, and the cavity 5 is positioned between the first open end 3 and the second open end 4; the two ends of the injection rod 2 are respectively provided with a contact end 21 and a pushing end 22, the contact end 21 is inserted into the cavity 5 through a second port, the contact end 21 is further provided with a sealing element 23, the sealing element 23 is tightly attached to the inner wall of the cavity 5 and can slide in the cavity 5, and the pushing end 22 is arranged on the outer side of the cavity 5; a convex extrusion port 6 is formed in the first opening end 3, a sealing plug 7 is arranged on the convex extrusion port 6, a groove 9 is formed in the center of the sealing plug 7, and the sealing plug 7 is detachably connected with the convex extrusion port 6 through the groove 9; a filter screen 11 is also arranged on the wall of the cavity 5 between the convex extrusion opening 6 and the sealing piece 23; the inner wall of the cavity 5, the inner wall of the convex extrusion opening 6, the surface of the sealing plug 7, the surface of the groove 9 and the surface of the filter screen 11 are all provided with antibacterial material layers.
Two sides of the second opening end 4 are provided with a force-borrowing plate 8, and the force-borrowing plate 8 is perpendicular to the injection tube body 1.
The injection tube body 1 is made of high polymer polypropylene material, and the injection rod 2 is made of high polymer polyvinyl chloride material.
The sealing member 23 is made of soft food-grade rubber.
The antibacterial material layer is food-grade resin added with antibacterial factors, wherein the antibacterial factors are porous polyethylene oxide microspheres compounded with chitosan and dehydroabietylamine.
The food-grade resin is one of unsaturated polyester resin, vinyl resin, epoxy resin and polyurethane.
The mass ratio of the antibacterial factor to the food-grade resin is 1: 36.
The preparation method of the porous polyethylene oxide microsphere compounded with chitosan and dehydroabietylamine comprises the following steps:
(1) weighing polyethylene oxide, adding the polyethylene oxide into distilled water, placing the mixture in a water bath at the temperature of 70-90 ℃, and stirring the mixture until the polyethylene oxide is completely dissolved to obtain a polyethylene oxide solution; weighing chitosan and dehydroabietylamine, adding the chitosan and dehydroabietylamine into a polyethylene oxide solution, stirring for 0.2-0.5 h under the condition of water bath at 70-90 ℃, dropwise adding a sulfuric acid solution with the mass fraction of 40-60%, and continuously stirring for 0.5-1 h to obtain a polyethylene oxide mixed solution;
wherein the mass ratio of the polyethylene oxide to the distilled water is 1: 18; the mass ratio of the chitosan to the dehydroabietylamine to the polyethylene oxide solution is 3:5: 22;
(2) putting dry ice into a vacuum flask, adding chloroform when the temperature in the vacuum flask is lower than 0 ℃, and adding the dry ice until the temperature in the vacuum flask is lower than-20 ℃ after the chloroform is completely added to obtain an ultra-low-temperature flowable dry ice-chloroform bath;
wherein the mass ratio of the dry ice to the chloroform in the dry ice-chloroform bath is 2.1: 3.2;
(3) and filling the polyethylene oxide mixed solution into an injector while the polyethylene oxide mixed solution is hot, dripping the polyethylene oxide mixed solution into a dry ice-chloroform bath through a needle with the diameter of 300-1000 mu m at the speed of 5-8 seconds per drop, collecting ice beads deposited at the bottom of the heat preservation bottle after dripping, quickly placing the ice beads into a drying box for freeze drying, then washing the ice beads for 3 times by using pure water, and placing the ice beads into the drying box at the temperature of 50-70 ℃ for reduced pressure drying to obtain the porous polyethylene oxide microspheres compounded with chitosan and dehydroabietylamine.
A silica gel filling apparatus comprising the above-mentioned injection device, which has all the functions of the injection device.
Example 2
An injection device, as shown in fig. 1, comprises an injection tube body 1 and an injection rod 2, wherein the injection tube body 1 comprises a first open end 3, a second open end 4 and a cavity 5, and the cavity 5 is positioned between the first open end 3 and the second open end 4; the two ends of the injection rod 2 are respectively provided with a contact end 21 and a pushing end 22, the contact end 21 is inserted into the cavity 5 through a second port, the contact end 21 is further provided with a sealing element 23, the sealing element 23 is tightly attached to the inner wall of the cavity 5 and can slide in the cavity 5, and the pushing end 22 is arranged on the outer side of the cavity 5; a convex extrusion port 6 is formed in the first opening end 3, a sealing plug 7 is arranged on the convex extrusion port 6, a groove 9 is formed in the center of the sealing plug 7, and the sealing plug 7 is detachably connected with the convex extrusion port 6 through the groove 9; a filter screen 11 is also arranged on the wall of the cavity 5 between the convex extrusion opening 6 and the sealing piece 23; the inner wall of the cavity 5, the inner wall of the convex extrusion opening 6, the surface of the sealing plug 7, the surface of the groove 9 and the surface of the filter screen 11 are all provided with antibacterial material layers.
Two sides of the second opening end 4 are provided with a force-borrowing plate 8, and the force-borrowing plate 8 is perpendicular to the injection tube body 1.
The injection tube body 1 is made of high polymer polypropylene material, and the injection rod 2 is made of high polymer polyvinyl chloride material.
The sealing member 23 is made of soft food-grade rubber.
The antibacterial material layer is food-grade resin added with antibacterial factors, wherein the antibacterial factors are porous polyethylene oxide microspheres compounded with chitosan and dehydroabietylamine.
The food-grade resin is one of unsaturated polyester resin, vinyl resin, epoxy resin and polyurethane.
The mass ratio of the antibacterial factor to the food-grade resin is 1: 50.
The preparation method of the porous polyethylene oxide microsphere compounded with chitosan and dehydroabietylamine comprises the following steps:
(1) weighing polyethylene oxide, adding the polyethylene oxide into distilled water, placing the mixture in a water bath at the temperature of 70-90 ℃, and stirring the mixture until the polyethylene oxide is completely dissolved to obtain a polyethylene oxide solution; weighing chitosan and dehydroabietylamine, adding the chitosan and dehydroabietylamine into a polyethylene oxide solution, stirring for 0.2-0.5 h under the condition of water bath at 70-90 ℃, dropwise adding a sulfuric acid solution with the mass fraction of 40-60%, and continuously stirring for 0.5-1 h to obtain a polyethylene oxide mixed solution;
wherein the mass ratio of the polyethylene oxide to the distilled water is 1: 12; the mass ratio of the chitosan to the dehydroabietylamine to the polyethylene oxide solution is 2:3: 18;
(2) putting dry ice into a vacuum flask, adding chloroform when the temperature in the vacuum flask is lower than 0 ℃, and adding the dry ice until the temperature in the vacuum flask is lower than-20 ℃ after the chloroform is completely added to obtain an ultra-low-temperature flowable dry ice-chloroform bath;
wherein the mass ratio of the dry ice to the chloroform in the dry ice-chloroform bath is 1.8: 2.2;
(3) and filling the polyethylene oxide mixed solution into an injector while the polyethylene oxide mixed solution is hot, dripping the polyethylene oxide mixed solution into a dry ice-chloroform bath through a needle with the diameter of 300-1000 mu m at the speed of 5-8 seconds per drop, collecting ice beads deposited at the bottom of the heat preservation bottle after dripping, quickly placing the ice beads into a drying box for freeze drying, then washing the ice beads for 3 times by using pure water, and placing the ice beads into the drying box at the temperature of 50-70 ℃ for reduced pressure drying to obtain the porous polyethylene oxide microspheres compounded with chitosan and dehydroabietylamine.
A silica gel filling apparatus comprising the above-mentioned injection device, which has all the functions of the injection device.
Example 3
An injection device, as shown in fig. 1, comprises an injection tube body 1 and an injection rod 2, wherein the injection tube body 1 comprises a first open end 3, a second open end 4 and a cavity 5, and the cavity 5 is positioned between the first open end 3 and the second open end 4; the two ends of the injection rod 2 are respectively provided with a contact end 21 and a pushing end 22, the contact end 21 is inserted into the cavity 5 through a second port, the contact end 21 is further provided with a sealing element 23, the sealing element 23 is tightly attached to the inner wall of the cavity 5 and can slide in the cavity 5, and the pushing end 22 is arranged on the outer side of the cavity 5; a convex extrusion port 6 is formed in the first opening end 3, a sealing plug 7 is arranged on the convex extrusion port 6, a groove 9 is formed in the center of the sealing plug 7, and the sealing plug 7 is detachably connected with the convex extrusion port 6 through the groove 9; a filter screen 11 is also arranged on the wall of the cavity 5 between the convex extrusion opening 6 and the sealing piece 23; the inner wall of the cavity 5, the inner wall of the convex extrusion opening 6, the surface of the sealing plug 7, the surface of the groove 9 and the surface of the filter screen 11 are all provided with antibacterial material layers.
Two sides of the second opening end 4 are provided with a force-borrowing plate 8, and the force-borrowing plate 8 is perpendicular to the injection tube body 1.
The injection tube body 1 is made of high polymer polypropylene material, and the injection rod 2 is made of high polymer polyvinyl chloride material.
The sealing member 23 is made of soft food-grade rubber.
The antibacterial material layer is food-grade resin added with antibacterial factors, wherein the antibacterial factors are porous polyethylene oxide microspheres compounded with chitosan and dehydroabietylamine.
The food-grade resin is one of unsaturated polyester resin, vinyl resin, epoxy resin and polyurethane.
The mass ratio of the antibacterial factor to the food-grade resin is 1: 15.
The preparation method of the porous polyethylene oxide microsphere compounded with chitosan and dehydroabietylamine comprises the following steps:
(1) weighing polyethylene oxide, adding the polyethylene oxide into distilled water, placing the mixture in a water bath at the temperature of 70-90 ℃, and stirring the mixture until the polyethylene oxide is completely dissolved to obtain a polyethylene oxide solution; weighing chitosan and dehydroabietylamine, adding the chitosan and dehydroabietylamine into a polyethylene oxide solution, stirring for 0.2-0.5 h under the condition of water bath at 70-90 ℃, dropwise adding a sulfuric acid solution with the mass fraction of 40-60%, and continuously stirring for 0.5-1 h to obtain a polyethylene oxide mixed solution;
wherein the mass ratio of the polyethylene oxide to the distilled water is 1: 20; the mass ratio of the chitosan to the dehydroabietylamine to the polyethylene oxide solution is 5:6: 25;
(2) putting dry ice into a vacuum flask, adding chloroform when the temperature in the vacuum flask is lower than 0 ℃, and adding the dry ice until the temperature in the vacuum flask is lower than-20 ℃ after the chloroform is completely added to obtain an ultra-low-temperature flowable dry ice-chloroform bath;
wherein the mass ratio of the dry ice to the chloroform in the dry ice-chloroform bath is 2.7: 3.6;
(3) and filling the polyethylene oxide mixed solution into an injector while the polyethylene oxide mixed solution is hot, dripping the polyethylene oxide mixed solution into a dry ice-chloroform bath through a needle with the diameter of 300-1000 mu m at the speed of 5-8 seconds per drop, collecting ice beads deposited at the bottom of the heat preservation bottle after dripping, quickly placing the ice beads into a drying box for freeze drying, then washing the ice beads for 3 times by using pure water, and placing the ice beads into the drying box at the temperature of 50-70 ℃ for reduced pressure drying to obtain the porous polyethylene oxide microspheres compounded with chitosan and dehydroabietylamine.
A silica gel filling apparatus comprising the above-mentioned injection device, which has all the functions of the injection device.
In order to more clearly illustrate the effects of the antibacterial material layer, the antibacterial material layers prepared in the embodiments 1 to 3 of the present invention are subjected to antibacterial performance detection and comparison, and the antibacterial material layers prepared in the embodiments 1, 2 and 3 of the present invention, which have the thickness of 0.05mm, the length of 1mm and the width of 1mm, are subjected to antibacterial performance detection by a bacteriostatic circle method against escherichia coli, staphylococcus aureus, bacillus subtilis, brewer's yeast, aspergillus flavus and pseudomonas aeruginosa, and the results are shown in table 1.
Table 1 comparison of the properties of different antibacterial material layers
As can be seen from Table 1, the antibacterial material layers prepared in the embodiments 1 to 3 of the present invention have good resistance to Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Saccharomyces cerevisiae, Aspergillus flavus, and Pseudomonas aeruginosa.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (9)
1. An injection device is characterized by comprising an injection tube body and an injection rod, wherein the injection tube body comprises a first opening end, a second opening end and a cavity, and the cavity is positioned between the first opening end and the second opening end; the two ends of the injection rod are respectively provided with a contact end and a pushing end, the contact end is inserted into the cavity through the second port, the contact end is also provided with a sealing element, the sealing element is tightly attached to the inner wall of the cavity and can slide in the cavity, and the pushing end is arranged on the outer side of the cavity; the first opening end is provided with a convex extrusion port, the convex extrusion port is provided with a sealing plug, the center of the sealing plug is provided with a groove, and the sealing plug is detachably connected with the convex extrusion port through the groove; a filter screen is also arranged on the wall of the cavity between the convex extrusion port and the sealing element; the inner wall of the cavity, the inner wall of the convex extrusion opening, the surface of the sealing plug, the surface of the groove and the surface of the filter screen are all provided with antibacterial material layers.
2. The injection device as claimed in claim 1, wherein the second open end is provided with force-applying plates at two sides thereof, and the force-applying plates are arranged perpendicular to the injection tube body.
3. The injection device as claimed in claim 1, wherein the injection tube body is made of a high polymer polypropylene material, and the injection rod is made of a high polymer polyvinyl chloride material.
4. An injection device according to claim 1, wherein the sealing member is made of a soft food grade rubber.
5. The injection device as claimed in claim 1, wherein the antibacterial material layer is a food grade resin added with antibacterial factors, wherein the antibacterial factors are porous polyethylene oxide microspheres compounded with chitosan and dehydroabietylamine.
6. An injection device according to claim 1, wherein the food grade resin is one of an unsaturated polyester resin, a vinyl resin, an epoxy resin, a polyurethane.
7. The injection device according to claim 1, wherein the mass ratio of the antibacterial factor to the food-grade resin is 1:15 to 50.
8. The injection device according to claim 1, wherein the porous polyethylene oxide microspheres compounded with chitosan and dehydroabietylamine are prepared by a method comprising:
(1) weighing polyethylene oxide, adding the polyethylene oxide into distilled water, placing the mixture in a water bath at the temperature of 70-90 ℃, and stirring the mixture until the polyethylene oxide is completely dissolved to obtain a polyethylene oxide solution; weighing chitosan and dehydroabietylamine, adding the chitosan and dehydroabietylamine into a polyethylene oxide solution, stirring for 0.2-0.5 h under the condition of water bath at 70-90 ℃, dropwise adding a sulfuric acid solution with the mass fraction of 40-60%, and continuously stirring for 0.5-1 h to obtain a polyethylene oxide mixed solution;
wherein the mass ratio of the polyethylene oxide to the distilled water is 1: 12-20; the mass ratio of the chitosan to the dehydroabietylamine to the polyethylene oxide solution is 2-5: 3-6: 18-25;
(2) putting dry ice into a vacuum flask, adding chloroform when the temperature in the vacuum flask is lower than 0 ℃, and adding the dry ice until the temperature in the vacuum flask is lower than-20 ℃ after the chloroform is completely added to obtain an ultra-low-temperature flowable dry ice-chloroform bath;
wherein the mass ratio of the dry ice to the chloroform in the dry ice-chloroform bath is 1.8-2.7: 2.2-3.6;
(3) and filling the polyethylene oxide mixed solution into an injector while the polyethylene oxide mixed solution is hot, dripping the polyethylene oxide mixed solution into a dry ice-chloroform bath through a needle with the diameter of 300-1000 mu m at the speed of 5-8 seconds per drop, collecting ice beads deposited at the bottom of the heat preservation bottle after dripping, quickly placing the ice beads into a drying box for freeze drying, then washing the ice beads for 3 times by using pure water, and placing the ice beads into the drying box at the temperature of 50-70 ℃ for reduced pressure drying to obtain the porous polyethylene oxide microspheres compounded with chitosan and dehydroabietylamine.
9. A silica gel filling apparatus comprising an injection device as claimed in any of claims 1 to 8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110114213.7A CN112890882A (en) | 2021-01-27 | 2021-01-27 | Injection device and silica gel filling equipment |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110114213.7A CN112890882A (en) | 2021-01-27 | 2021-01-27 | Injection device and silica gel filling equipment |
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| CN112890882A true CN112890882A (en) | 2021-06-04 |
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| CN202110114213.7A Withdrawn CN112890882A (en) | 2021-01-27 | 2021-01-27 | Injection device and silica gel filling equipment |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060175242A1 (en) * | 2005-02-07 | 2006-08-10 | Hanuman Llc | Method and apparatus for preparing platelet rich plasma and concentrates thereof |
| US20110212179A1 (en) * | 2008-10-30 | 2011-09-01 | David Liu | Micro-spherical porous biocompatible scaffolds and methods and apparatus for fabricating same |
| US20150071982A1 (en) * | 2013-09-06 | 2015-03-12 | The Trustees Of The University Of Pennsylvania | Antimicrobial polymer layers |
| CN206167532U (en) * | 2016-08-16 | 2017-05-17 | 四川省金核辐照技术有限公司 | Safe and reliable's syringe structure |
| CN209347310U (en) * | 2018-12-28 | 2019-09-06 | 重庆当代整形美容医院有限公司 | A kind of injection device and silicone filler equipment |
-
2021
- 2021-01-27 CN CN202110114213.7A patent/CN112890882A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060175242A1 (en) * | 2005-02-07 | 2006-08-10 | Hanuman Llc | Method and apparatus for preparing platelet rich plasma and concentrates thereof |
| US20110212179A1 (en) * | 2008-10-30 | 2011-09-01 | David Liu | Micro-spherical porous biocompatible scaffolds and methods and apparatus for fabricating same |
| US20150071982A1 (en) * | 2013-09-06 | 2015-03-12 | The Trustees Of The University Of Pennsylvania | Antimicrobial polymer layers |
| CN206167532U (en) * | 2016-08-16 | 2017-05-17 | 四川省金核辐照技术有限公司 | Safe and reliable's syringe structure |
| CN209347310U (en) * | 2018-12-28 | 2019-09-06 | 重庆当代整形美容医院有限公司 | A kind of injection device and silicone filler equipment |
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