CN112881345B - Sample analyzer hole site configuration method and device, computer equipment and sample analyzer - Google Patents
Sample analyzer hole site configuration method and device, computer equipment and sample analyzer Download PDFInfo
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- CN112881345B CN112881345B CN201911204765.6A CN201911204765A CN112881345B CN 112881345 B CN112881345 B CN 112881345B CN 201911204765 A CN201911204765 A CN 201911204765A CN 112881345 B CN112881345 B CN 112881345B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/59—Transmissivity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Abstract
The invention provides a sample analyzer hole site configuration method, a sample analyzer hole site configuration device, computer equipment and a sample analyzer, wherein the method comprises the following steps: acquiring a target detection period of the sample analyzer, wherein the target detection period is a time interval between two adjacent output detection results; obtaining a target incubation time of a standard sample; determining the configuration number of incubation hole sites in the incubation region according to the target detection period and the target incubation time; obtaining the detection time of a sample; determining the configuration number of detection hole sites in the detection area according to the target detection period and the detection time; and carrying out hole site configuration on the sample analyzer according to the configuration number of the incubation hole sites and the configuration number of the detection hole sites. By the sample analyzer hole site configuration method, the hole sites in the sample analyzer are configured, high-speed cyclic detection of the sample analyzer is met, detection efficiency is improved, and the size of the sample analyzer can be greatly reduced.
Description
Technical Field
The invention relates to the field of sample detection, in particular to a sample analyzer hole site configuration method and device, computer equipment and a sample analyzer.
Background
With the continuous development of in vitro diagnostic technology, the sample analyzer has wide application, hole sites for incubation and detection are arranged in the sample analyzer, and a sample is efficiently detected by the sample analyzer.
Some of the existing sample analyzers can meet the requirement of circular detection, but the volume of the analyzer is overlarge; some instruments are suitable in volume but cannot meet the requirement of circular detection.
Disclosure of Invention
In view of the above, it is desirable to provide a sample analyzer hole site arrangement method, device, computer equipment and sample analyzer.
In a first aspect, an embodiment of the present invention provides a method for configuring a hole site of a sample analyzer, including the following steps:
acquiring a target detection period of the sample analyzer, wherein the target detection period is a time interval between two adjacent output detection results;
obtaining a target incubation time of a standard sample;
determining the configuration number of incubation hole sites in the incubation region according to the target detection period and the target incubation time;
obtaining the detection time of a sample;
determining the configuration number of detection hole sites in the detection area according to the target detection period and the detection time;
and carrying out hole site configuration on the sample analyzer according to the configuration number of the incubation hole sites and the configuration number of the detection hole sites.
In one embodiment, detecting hole locations comprises: scattering detection hole site and transmission detection hole site, the check-out time includes: a scattering detection time and a transmission detection time;
determining the configuration number of detection hole sites in the detection area according to the target detection period and the detection time, wherein the configuration number comprises the following steps:
determining the configuration number of scattering detection hole sites in the detection area according to the target detection period and the scattering detection time;
and determining the configuration number of the transmission detection hole sites in the detection area according to the target detection period and the transmission detection time.
In one embodiment, determining the number of the transmission detection hole sites in the detection area according to the target detection period and the transmission detection time includes:
acquiring the quantity of the reagent required to be added for transmission detection;
and determining the configuration number of the transmission detection hole sites in the detection area according to the number of the reagents, the target detection period and the transmission detection time.
In one embodiment, the method further comprises:
acquiring activation time corresponding to an added reagent required by sample detection;
and determining the configuration number of the activated pore sites in the detection area according to the target detection period and the activation time of the reagent.
In one embodiment, there are a plurality of reagents to be added, and the method further comprises:
acquiring the type of a reagent to be added and the corresponding activation time of each reagent;
determining the configuration number of activated pore sites in the detection zone according to the target detection period and the activation time of the reagent, wherein the configuration number comprises the following steps:
obtaining the number of activated hole site configurations which meet the requirements and correspond to each reagent according to the target detection period and the activation time corresponding to each reagent;
and determining the configuration number of the largest activation hole site in the configuration number of the activation hole sites which meet the requirements corresponding to each reagent as the configuration number of the activation hole sites in the detection area.
In one embodiment, the method further comprises:
acquiring first activation time of an added reagent required by sample scattering detection;
acquiring second activation time of the added reagent required by sample transmission detection;
obtaining the configuration number of the activation hole sites meeting the scattering detection according to the target detection period and the first activation time;
obtaining the configuration number of the activation hole sites meeting the transmission detection according to the target detection period and the second activation time;
and determining the larger value of the configuration number of the activated hole sites meeting the scattering detection and the configuration number of the activated hole sites meeting the transmission detection as the configuration number of the activated hole sites in the detection area.
In one embodiment, determining the configured number of incubation well locations in the incubation area according to the target detection period and the target incubation time comprises:
calculating a first ratio of the target incubation time to the target detection period;
determining the configuration number of incubation hole sites according to the first ratio;
determining the configuration number of detection hole sites in the detection area according to the target detection period and the detection time, wherein the configuration number comprises the following steps:
calculating a second ratio of the detection time to the target detection period;
and determining the configuration number of the detection hole positions according to the second ratio.
In a second aspect, an embodiment of the present invention provides an apparatus for configuring a hole site of a sample analyzer, including:
the first acquisition module is used for acquiring a target detection period of the sample analyzer, wherein the target detection period is a time interval between two adjacent detection results;
the second acquisition module is used for acquiring the target incubation time of the standard sample;
the first determining module is used for determining the configuration number of incubation hole sites in the incubation region according to the target detection period and the target incubation time;
the third acquisition module is used for acquiring the detection time of the sample;
the second determining module is used for determining the configuration number of detection hole positions in the detection area according to the target detection period and the detection time;
and the configuration module is used for carrying out hole site configuration on the sample analyzer according to the configuration number of the incubation hole sites and the configuration number of the detection hole sites.
In a third aspect, an embodiment of the present invention provides a computer device, including a memory and a processor, where the memory stores a computer program, and the processor is configured to call the computer program in the memory to execute the following steps:
acquiring a target detection period of the sample analyzer, wherein the target detection period is a time interval between two adjacent output detection results;
obtaining a target incubation time of a standard sample;
determining the configuration number of incubation hole sites in the incubation region according to the target detection period and the target incubation time;
obtaining the detection time of a sample;
determining the configuration number of detection hole sites in the detection area according to the target detection period and the detection time;
and carrying out hole site configuration on the sample analyzer according to the configuration number of the incubation hole sites and the configuration number of the detection hole sites.
In a fourth aspect, an embodiment of the present invention provides a sample analyzer, including an incubation region and a detection region, where the number of corresponding well sites in the incubation region and the detection region is determined by the following steps:
acquiring a target detection period of the sample analyzer, wherein the target detection period is a time interval between two adjacent output detection results;
obtaining the target incubation time of a standard sample;
determining the configuration number of incubation hole sites in the incubation region according to the target detection period and the target incubation time;
obtaining the detection time of a sample;
determining the configuration number of detection hole sites in the detection area according to the target detection period and the detection time;
and carrying out hole site configuration on the sample analyzer according to the configuration number of the incubation hole sites and the configuration number of the detection hole sites.
By the sample analyzer hole site configuration method and device, the computer equipment and the sample analyzer, the hole sites in the sample analyzer are configured, high-speed cyclic detection of the sample analyzer is met, the detection efficiency is improved, and meanwhile the size of the sample analyzer can be greatly reduced.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
Wherein:
FIG. 1 is a flow chart of a sample analyzer well placement configuration method in one embodiment;
FIG. 2 is a flow chart of a sample analyzer well placement configuration method in one embodiment;
FIG. 3 is a flow chart of a sample analyzer well placement configuration method in one embodiment;
FIG. 4 is a flow chart of a sample analyzer well placement configuration method in one embodiment;
FIG. 5 is a flow chart of a sample analyzer well placement configuration method in one embodiment;
FIG. 6 is a flow chart of a sample analyzer well placement configuration method in one embodiment;
FIG. 7 is a flow diagram of performing sample analysis in one embodiment;
FIG. 8 is a block diagram of the sample analyzer in one embodiment;
FIG. 9 is a schematic diagram showing the structure of a hole site placement apparatus for a sample analyzer in one embodiment;
FIG. 10 is a diagram showing an internal structure of a computer device according to an embodiment.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
As shown in fig. 1, a device module configuration method is provided, which specifically includes the following steps:
The target detection period refers to an expected time interval between two adjacent detection results. The target detection period specifically refers to the time for obtaining an output result in the continuous operation of the sample analyzer, and does not include the incubation time and the detection time. For example, a sample analyzer includes: the sampling position, the incubation area and the detection area are characterized in that firstly, in a sample analyzer, t1 time is needed from the sampling position to the incubation area, a sample cup to be incubated is placed in the incubation area, then t2 time is needed for immediately taking out a sample cup which is incubated completely from the incubation area, then t3 time is needed for immediately placing the sample cup which is incubated completely and taken out from the incubation area into the detection area and then immediately taking out the sample cup which is detected completely from the detection area, then the total time is t1+ t2+ t3, the target detection period is not less than t, and in short, the target detection period is a time fixed value which meets t. Therefore, in the high-speed cyclic detection process, a detection result is output every time an object detection period passes.
The standard sample refers to a representative sample selected. The standard sample generally used refers to a sample meeting the relevant parameters required to be met by most of sample detection, and the sample analyzer can meet the detection requirements of most of samples by being used for configuring the sample analyzer hole sites. The target incubation time is an incubation time corresponding to a standard sample, and the sample needs to be heated to a certain temperature in the detection process to enable the reaction efficiency to be the highest, so that the time for heating the sample to reach the required temperature is the incubation time.
And 106, determining the configuration number of the incubation holes in the incubation region according to the target detection period and the target incubation time.
In the case where the target detection period and the target incubation time are known, the number of the incubation wells that satisfy the minimum cycle can be calculated. In one embodiment, the configured number of incubation wells can be calculated by using the ratio of the target incubation time to the target detection period. For example, if the target incubation time is T and the target detection period is T, the configuration number of incubation holes is: n is T/T.
In another embodiment, when the configuration number of the incubation holes is calculated, a preset proportionality coefficient is obtained, and the configuration number of the incubation holes is determined according to the preset proportionality coefficient, the target detection period and the target incubation time. The proportionality coefficient may be a positive integer, and may be specifically determined according to the type of the sample to be detected in the apparatus, for example, if the proportionality coefficient is k, the configuration number of the incubation hole sites at this time is: n2 ═ T/T × k.
The detection time refers to the time that the sample needs to stay in the detection channel after completing the incubation and activation, and the detection time is actually the time that the detection process needs to take because the detection needs a certain time. Because the change of the optical signal in the sample solidification process with time needs to be recorded in the optical detection process, so as to draw a corresponding curve or image, and finally, the required solidification time point is calculated based on the acquired curve or image, that is, in order to obtain the solidification time point, a detection process is needed, and the time spent by the process is the detection time.
And step 110, determining the configuration number of detection hole positions in the detection area according to the target detection period and the detection time.
When the target detection period and the detection time are known, the number of the detection holes that satisfy the minimum cycle can be calculated. In one embodiment, the configured number of detection hole sites may be calculated by using a ratio of the detection time to the target detection period. For example, if the target detection time is T1 and the target detection period is T, the configuration number of the incubation holes is: and m is T1/T.
In another embodiment, when the configuration number of the detection well sites is calculated, a proportionality coefficient is obtained, and the configuration number of the incubation well sites is determined according to the proportionality coefficient, the target detection period and the target incubation time. The scaling factor may be a positive integer, and may be specifically determined according to the type of samples that need to be detected simultaneously in the instrument, for example, if the scaling factor is k, the number of the detection holes configured at this time is: m2 ═ T1/T × k.
And 112, carrying out hole site configuration on the sample analyzer according to the configuration number of the incubation hole sites and the configuration number of the detection hole sites.
After the configuration number of the incubation hole sites and the configuration number of the detection hole sites are known, the configuration numbers of the incubation hole sites and the detection hole sites in the sample analyzer are set according to the configuration numbers.
By the sample analyzer hole site configuration method, the hole sites in the sample analyzer are configured, high-speed cyclic detection of the sample analyzer is met, detection efficiency is improved, and the size of the sample analyzer can be greatly reduced.
In one embodiment, detecting the hole locations comprises: scattering detection hole site and transmission detection hole site, the check-out time includes: a scatter detection time and a transmission detection time; determining the configuration number of detection hole sites in the detection area according to the target detection period and the detection time, wherein the configuration number comprises the following steps: determining the configuration number of scattering detection hole sites in a detection area according to the target detection period and the scattering detection time; and determining the configuration number of the transmission detection hole sites in the detection area according to the target detection period and the transmission detection time.
The optical detection method is generally adopted in sample detection, and comprises scattering detection and transmission detection, wherein the light setting angles required by the scattering detection and the transmission detection are different, so that two different detection hole positions are required for the scattering detection and the transmission detection. In addition, in the above calculation of the configuration number of the detection hole sites, the two specific detection modes of scattering detection and transmission detection are refined, and under the condition that the target detection period and the scattering detection time are known, the configuration number of the scattering detection hole sites which meets the minimum limit of circulation can be obtained through calculation; with the target detection period and the transmission detection time known, the number of the transmission detection holes that satisfies the minimum limit of the cycle can be calculated. In this embodiment, the detection modes include scattering detection and transmission detection, but are not limited to these two detection modes, and the hole site number of other detection modes can also be calculated by this method.
The detection efficiency of the detection hole sites in the sample analyzer is greatly improved by configuring the configuration number of the detection hole sites.
As shown in FIG. 2, in one embodiment, determining the number of through-detection-hole locations in the detection area according to the target detection period and the through-detection time includes:
step 202, the amount of reagent added for transmission detection is obtained.
Among them, in the transmission detection, the multi-reagent detection is generally performed, and each reagent detection in the multi-reagent detection is independent, and the detection of one reagent is performed before the detection of the next reagent.
And 204, determining the configuration number of the transmission detection hole sites in the detection area according to the number of the reagents, the target detection period and the transmission detection time.
Among them, since the transmission detection uses a plurality of reagents, the transmission detection time is the total time including the detection of a plurality of reagents, and therefore, it is necessary to comprehensively consider the total time and the number of reagents when determining the number of positions of the holes for transmission detection. When the target detection period, the transmission detection time, and the amount of the transmission detection reagent are known, the number of the transmission detection wells that satisfies the minimum cycle can be calculated. In an embodiment, the number of the transmissive detection holes may be calculated by using a ratio of the transmissive detection time to a product of the target detection period and the number of the transmissive detection reagents, for example, the transmissive detection time is 100s, the target detection period is 9s, and the number of the transmissive detection reagents is 2, then the number of the corresponding transmissive detection holes is 100/(9 × 2) is 5.5, and the number of the transmissive detection holes is obtained by rounding up, that is, the number of the transmissive detection holes is 6.
In another embodiment, when calculating the number of configured positions of the hole sites for transmission detection, a scaling factor may be obtained, and the number of configured positions of the hole sites for transmission detection may be determined according to the scaling factor, the target detection period, the transmission detection time, and the number of transmission detection reagents.
The configuration number of the transmission detection hole sites is comprehensively determined by combining the detection time and the reagent number of the transmission detection, so that the detection efficiency of the transmission detection hole sites is improved.
In one embodiment, the sample analyzer well site configuration method further comprises: acquiring activation time corresponding to an added reagent required by sample detection; and determining the configuration number of the activated pore sites in the detection area according to the target detection period and the activation time of the reagent.
In the sample detection, some items need to be activated to better detect the sample, so that an activation hole is additionally arranged in the detection area. The activation time refers to the time required to activate the agent. The activation time is obtained to calculate the number of the activation holes.
When the target detection period and the activation time are known, the minimum number of the activation holes that satisfy the cycle can be calculated. In one embodiment, the configured number of activated holes may be calculated by using a ratio of the activation time to the target detection period.
In another embodiment, when the configuration number of the activated hole sites is calculated, a scaling factor may also be obtained, and the configuration number of the activated hole sites is determined according to the scaling factor, the target detection period, and the activation time.
The detection efficiency of the activated hole sites is also improved by determining the configuration number of the activated hole sites by considering the activation time.
As shown in fig. 3, in an embodiment, when a plurality of reagents are added, the sample analyzer well location configuration method further includes:
Among them, detection in a part of items requires a plurality of reagents, and the plurality of reagents all require activation, so that it is necessary to acquire an activation time corresponding to each reagent.
And 304, obtaining the configuration number of the activation holes corresponding to each reagent and meeting the requirement according to the target detection period and the activation time corresponding to each reagent.
Since the activation times for the respective reagents are not necessarily the same, the number of active pore sites to be arranged for each activation time is calculated for each reagent, and the total determination is performed.
And step 306, determining the configuration number of the activation hole sites with the maximum configuration number of the activation hole sites which meet the requirements corresponding to each reagent as the configuration number of the activation hole sites in the detection area.
Wherein, in the case where the number of active pore sites corresponding to the activation time is known for each reagent, the maximum number is selected as the number of active pore sites arranged in the detection region so that the activation time corresponding to the reagent is satisfied.
The number of the activation holes which can meet the activation time corresponding to all reagents is obtained by considering the activation time corresponding to a plurality of reagents, and the applicability of the number of the configured activation holes is improved.
As shown in fig. 4, in an embodiment, the sample analyzer well site configuration method further includes:
at step 402, a first activation time of an added reagent required for a sample scatter detection is obtained.
In the sample detection, the activity requirements of the scattering detection and the transmission detection on the reagent are different, so that the activation time required for the reagent is different, the activation times corresponding to the detection requirements of the scattering detection and the transmission detection need to be respectively obtained, and the first activation time meeting the scattering detection needs to be obtained in the step.
At step 404, a second activation time of the added reagent required for transmission detection of the sample is obtained.
Here, the synchronization step 502 is the same, and in this step, a second activation time satisfying the transmission detection needs to be acquired.
And 406, obtaining the configuration number of the activated hole sites meeting the scattering detection according to the target detection period and the first activation time.
The number of the activated hole sites which meet the scattering detection requirement can be obtained in the known target detection period and the known first activation time as the number of the calculated hole sites.
And step 408, obtaining the configuration number of the activation hole sites meeting the transmission detection according to the target detection period and the second activation time.
Wherein, the same as the above-mentioned configuration number of the calculation hole sites, the configuration number of the activation hole sites satisfying the transmission detection can be obtained by knowing the target detection period and the second activation time.
After the activated hole sites corresponding to the two detection modes of scattering and transmission are obtained, the configuration number of the activated hole sites required by the two detection modes can be met at the same time by selecting the larger value of the calculation result and determining the configuration number of the activated hole sites in the detection area.
The number of the activated hole sites which can meet the requirements of all scattering detection and all transmission detection is obtained by considering the activation time required by the two detection modes of scattering and transmission, and the applicability of the configuration number of the configured activated hole sites is improved.
In one embodiment, determining the configured number of incubation well locations in the incubation area according to the target detection period and the target incubation time comprises: calculating a first ratio of the target incubation time to the target detection period; and determining the configuration number of the incubation hole sites according to the first ratio.
Determining the configuration number of detection hole sites in the detection area according to the target detection period and the detection time, wherein the configuration number comprises the following steps: calculating a second ratio of the detection time to the target detection period; and determining the configuration number of the detection hole sites according to the second ratio.
In order to determine the configuration number of the incubation holes, firstly, the ratio of the target incubation time to the target detection period is calculated, and for distinguishing, the ratio is called as a "first ratio", and then the configuration number of the incubation holes is obtained according to the first ratio. For example, if the target incubation time is 120s and the target detection period is 9s, the first ratio obtained is 120/9-13.33, and the number of the incubation holes is at least 14. Similarly, in order to determine the configured number of the detection hole sites, a second ratio of the detection time to the target detection period is calculated, and when the second ratio is not an integer, rounding up is performed to obtain at least the configured number of the detection hole sites.
As shown in FIG. 5, in one embodiment, the number of the incubation well sites, the scatter detection well sites and the activation well sites is determined by the following steps:
And step 506, calculating the quotient corresponding to the incubation time, the scattering detection time and the activation time.
And step 508, determining the quotient values corresponding to the incubation time, the scattering detection time and the activation time as the configuration number of the incubation hole site, the scattering detection hole site and the activation hole site respectively.
Wherein, steps 502 to 508 are specific steps and calculation formulas for determining the configuration number of the incubation well site, the scattering detection well site and the activation well site. The target detection period refers to a time limit within which the total time taken for taking out and putting in a sample cup once in each hole site region in the sample analyzer is not more than one, and a detection result can be output after completing one target detection period in the cyclic process of cyclic detection.
To make this embodiment clearer, for example, if a sample cup needs to be incubated in an incubation region for 120s in a sample analyzer, and the obtained target detection period is 9s, then the number of incubation wells in the incubation region is: 120/9 is 13.33, and according to the result, the operation amount of 13.33 target detection cycles can be completed in the period from the beginning to the completion of the incubation of one sample cup in the cycle process. Assuming that the sample cup is placed in the first incubation hole, the operation amount of one target detection period is completed after 9s, placing the second sample cup in the second incubation hole, and so on. When the thirteenth sample is placed in the thirteenth incubation hole, 12 × 9 — 108s has passed, at this time, the first sample cup needs to be incubated for 12s, and then when the fourteenth sample cup is placed in the fourteenth incubation hole, the first sample cup has been incubated for 117s, that is, after the fourteenth sample cup is placed in the fourteenth sample hole, 3s of incubation of the first sample cup is required, the 3s cycle is less than one, so that when the fifteenth sample cup is placed, the first sample cup has been incubated, and then the fifteenth sample cup can be placed in the first incubation hole. Thus, in the above case the final defined number of incubation well sites is 14, and 14 incubation well sites is the lowest well site number that meets the cycling requirements. Similarly, the calculation methods of the activated hole site and the scattering detection hole site are the same, and are not described herein again.
The number of the incubation hole sites, the scattering detection hole sites and the activation hole sites is configured, so that the requirements of the minimum number of the cyclic detection incubation hole sites, the minimum number of the scattering detection hole sites and the minimum number of the activation hole sites are met, and the balance of limiting the volume of the instrument is achieved.
In one embodiment, the number of the holes for transmission detection is obtained by the following steps:
And 606, calculating a quotient corresponding to the transmission detection time.
The principles of calculating the number of the incubation holes, the activation holes and the scattering detection holes are the same as those of the above steps 502 to 508, and the difference is that the number of the reagents is considered for the transmission detection which is the multi-reagent detection. Specifically, if the transmission detection time is 100s, the detection time of 100s includes the detection of 2 reagents, and the obtained target detection period is also 9s, then the number of transmission detection holes at this time is: 100/2/9 is 5.56, and it should be noted that each reagent is detected independently in the transmission detection, that is, the detection time of each reagent in 100s is: 100/2 is 50s, and the lowest transmission detection hole position satisfying the cycle can be obtained by calculating the 50 s.
The transmission detection hole sites are configured, so that the balance of meeting the requirement of the minimum number of the cyclic transmission detection hole sites and limiting the volume of the instrument is achieved.
In order to make the present invention easier to understand, the working flow of the sample analyzer of the present invention is now described, as shown in fig. 7, the test is started, whether there is an empty incubation hole, if there is an empty incubation hole, a sample cup containing a sample to be tested is placed in the empty incubation hole for incubation; judging whether an empty activating hole site exists or not, if so, taking out a sample cup which finishes incubation from the incubating hole site, putting the sample cup into the empty activating hole site, and adding a reagent R1 to be activated for activation; and then judging whether an empty detection hole site exists or not, if so, taking out a sample cup which is activated from the activation hole site, putting the sample cup into the empty detection hole site, adding an R2 reagent for detection, and finally, finishing the detection and finishing the whole process.
As shown in fig. 8, fig. 8 shows the positional relationship between the region setting and the hole position setting in the region in the sample analyzer, and first, the sample analyzer has a sampling region, an incubation region and a detection region therein, wherein the sampling region is provided with a plurality of sampling hole positions, the incubation region is provided with a plurality of incubation hole positions, and the detection region is provided with a plurality of activation hole positions, a plurality of scattering detection hole positions and a plurality of transmission detection hole positions.
As shown in fig. 9, in one embodiment, the present invention provides an apparatus for arranging sample analyzer holes, including:
a first obtaining module 902, configured to obtain a target detection period of the sample analyzer, where the target detection period is a time interval between two adjacent detection results;
a second obtaining module 904, configured to obtain a target incubation time of the standard sample;
a first determining module 906, configured to determine the configuration number of incubation holes in the incubation region according to the target detection period and the target incubation time;
a third obtaining module 908 for obtaining a detection time of the sample;
a second determining module 910, configured to determine the configured number of detection hole locations in the detection area according to the target detection period and the detection time;
a configuration module 912, configured to configure the pore locations of the sample analyzer according to the configured number of the incubation pore locations and the configured number of the detection pore locations.
In one embodiment, the second determining module is further configured to determine the number of scattering detection holes in the detection area according to the target detection period and the scattering detection time, and determine the number of transmission detection holes in the detection area according to the target detection period and the transmission detection time.
In one embodiment, the second determination module is further configured to obtain the amount of the reagent required to be added for the transmittance detection, and determine the configured number of the holes in the transmittance detection area according to the amount of the reagent, the target detection period, and the transmittance detection time.
In one embodiment, the sample analyzer well site configuration device further includes:
and the third determining module is used for acquiring the activation time corresponding to the added reagent required by the sample detection, and determining the configuration number of the activated hole sites in the detection area according to the target detection period and the activation time of the reagent.
In one embodiment, the sample analyzer well site configuration device further includes:
the fourth acquisition module is used for acquiring the type of the reagent to be added and the activation time corresponding to each reagent;
the third determining module is further configured to obtain the configuration number of the activation hole sites corresponding to each reagent and meeting the requirement according to the target detection period and the activation time corresponding to each reagent, and determine the configuration number of the activation hole site with the largest configuration number of the activation hole sites corresponding to each reagent and meeting the requirement as the configuration number of the activation hole sites in the detection region.
In one embodiment, the sample analyzer well site configuration device further includes:
the fifth acquisition module is used for acquiring the first activation time of the reagent required to be added for sample scattering detection and acquiring the second activation time of the reagent required to be added for sample transmission detection;
and the fourth determining module is further configured to obtain the configuration number of the activation hole sites meeting the scattering detection according to the target detection period and the first activation time, obtain the configuration number of the activation hole sites meeting the transmission detection according to the target detection period and the second activation time, and determine the larger value of the configuration number of the activation hole sites meeting the scattering detection and the configuration number of the activation hole sites meeting the transmission detection as the configuration number of the activation hole sites in the detection area.
In one embodiment, the first determining module is further configured to calculate a first ratio of the target incubation time to the target detection period; determining the configuration number of incubation hole sites according to the first ratio; the second determining module is further used for calculating a second ratio of the detection time to the target detection period; and determining the configuration number of the detection hole positions according to the second ratio.
In one embodiment, a computer device is provided, the internal structure of which is shown in fig. 10. The computer device includes a processor, a memory, and a network interface connected by a system bus. The memory comprises a nonvolatile storage medium and an internal memory. The non-volatile storage medium of the computer device stores an operating system and may also store a computer program that, when executed by the processor, causes the processor to implement the sample analyzer hole site configuration method. The internal memory may also have stored therein a computer program that, when executed by the processor, causes the processor to perform a sample analyzer hole site placement method. Those skilled in the art will appreciate that the architecture shown in fig. 10 is merely a block diagram of some of the structures associated with the disclosed aspects and is not intended to limit the computing devices to which the disclosed aspects apply, as particular computing devices may include more or less components than those shown, or may combine certain components, or have a different arrangement of components.
In one embodiment, the sample analyzer hole site configuration method provided herein can be implemented in the form of a computer program that can be run on a computer device as shown in fig. 10. The memory of the computer device can store various program modules which form the sample analyzer hole site configuration device. Such as an acquisition module 902 and a determination module 904.
A computer device comprising a memory having a computer program stored therein and a processor for invoking the computer program in the memory to perform the steps of: acquiring a target detection period of the sample analyzer, wherein the target detection period is a time interval for outputting a detection result; obtaining a target incubation time of a standard sample; determining the configuration number of incubation hole sites in the incubation region according to the target detection period and the target incubation time; obtaining the detection time of a sample; determining the configuration number of detection hole sites in the detection area according to the target detection period and the detection time; and carrying out hole site configuration on the sample analyzer according to the configuration number of the incubation hole sites and the configuration number of the detection hole sites.
In one embodiment, detecting hole locations comprises: scattering detection hole site and transmission detection hole site, the check-out time includes: a scattering detection time and a transmission detection time; determining the configuration number of detection hole sites in the detection area according to the target detection period and the detection time, wherein the configuration number comprises the following steps:
determining the configuration number of scattering detection hole sites in the detection area according to the target detection period and the scattering detection time; and determining the configuration number of the transmission detection hole sites in the detection area according to the target detection period and the transmission detection time.
In one embodiment, determining the number of the transmission detection hole sites in the detection area according to the target detection period and the transmission detection time includes: acquiring the quantity of the reagent required to be added for transmission detection; and determining the configuration number of the transmission detection hole sites in the detection area according to the number of the reagents, the target detection period and the transmission detection time.
In one embodiment, the processor is further configured to invoke a computer program in the memory to perform the steps of: acquiring activation time corresponding to an added reagent required by sample detection; and determining the configuration number of the activated pore sites in the detection area according to the target detection period and the activation time of the reagent.
In one embodiment, the number of agents to be added is multiple, and the processor is further configured to invoke the computer program in the memory to perform the steps of: acquiring the type of a reagent to be added and the corresponding activation time of each reagent; determining the configuration number of activated pore sites in the detection zone according to the target detection period and the activation time of the reagent, wherein the configuration number comprises the following steps: obtaining the configuration number of the activation holes corresponding to each reagent and meeting the requirements according to the target detection period and the activation time corresponding to each reagent; and determining the configuration number of the activation hole sites which is the largest in the configuration number of the activation hole sites which meet the requirements corresponding to each reagent as the configuration number of the activation hole sites in the detection area.
In one embodiment, the processor is further configured to invoke a computer program in the memory to perform the steps of: acquiring first activation time of an added reagent required by sample scattering detection; acquiring a second activation time of the added reagent required by the sample transmission detection; obtaining the configuration number of the activation hole sites meeting the scattering detection according to the target detection period and the first activation time; obtaining the configuration number of the activation hole sites meeting the transmission detection requirement according to the target detection period and the second activation time; and determining the larger value of the configuration number of the activation hole sites meeting the scattering detection requirement and the configuration number of the activation hole sites meeting the transmission detection requirement as the configuration number of the activation hole sites in the detection area.
In one embodiment, the number of the incubation well sites, the scatter detection well sites and the activation well sites is determined by the following steps: taking the incubation time, the scattering detection time and the activation time as dividends respectively; taking the target detection period as a divisor; calculating to obtain quotient values corresponding to the incubation time, the scattering detection time and the activation time; respectively determining the quotient values corresponding to the incubation time, the scattering detection time and the activation time as the configuration quantity of the incubation hole sites, the scattering detection hole sites and the activation hole sites;
the configuration number of the transmission detection hole sites is obtained by the following steps: taking the transmission detection time as a dividend; taking the product of the target detection period and the quantity of the reagent required by transmission detection as a divisor; calculating to obtain a quotient value corresponding to the transmission detection time; and determining the quotient corresponding to the transmission detection time as the configuration number of the transmission detection hole sites.
In one embodiment, determining the configured number of incubation well locations in the incubation area according to the target detection period and the target incubation time comprises: calculating a first ratio of the target incubation time to the target detection period; determining the configuration number of incubation hole sites according to the first ratio; determining the configuration number of detection hole sites in the detection area according to the target detection period and the detection time, wherein the configuration number comprises the following steps: and calculating a second ratio of the detection time to the target detection period, and determining the configuration number of the detection hole sites according to the second ratio.
In one embodiment, the present invention provides a sample analyzer comprising an incubation area and a detection area, wherein the number of corresponding well locations in the incubation area and the detection area is determined by the following steps: acquiring a target detection period of the sample analyzer, wherein the target detection period is a time interval for outputting a detection result; obtaining a target incubation time of a standard sample; determining the configuration number of incubation hole sites in the incubation region according to the target detection period and the target incubation time; obtaining the detection time of a sample; and determining the configuration number of detection hole positions in the detection area according to the target detection period and the detection time.
In one embodiment, the number of corresponding well locations in the detection zone is determined by: determining the configuration number of scattering detection hole sites in the detection area according to the target detection period and the scattering detection time; and determining the configuration number of the transmission detection hole sites in the detection area according to the target detection period and the transmission detection time.
In one embodiment, the number of corresponding well locations in the detection zone is determined by: acquiring the quantity of the reagent required to be added for transmission detection; and determining the configuration number of the transmission detection hole sites in the detection area according to the number of the reagents, the target detection period and the transmission detection time.
In one embodiment, the number of corresponding well locations in the detection zone is determined by: acquiring activation time corresponding to an added reagent required by sample detection; and determining the configuration number of the activated pore sites in the detection area according to the target detection period and the activation time of the reagent.
In one embodiment, the number of corresponding well locations in the detection zone is determined by: acquiring the type of a reagent to be added and the corresponding activation time of each reagent; determining the configuration number of activated pore sites in the detection zone according to the target detection period and the activation time of the reagent, wherein the configuration number comprises the following steps: obtaining the configuration number of the activation holes corresponding to each reagent and meeting the requirements according to the target detection period and the activation time corresponding to each reagent; and determining the configuration number of the activation hole sites which is the largest in the configuration number of the activation hole sites which meet the requirements corresponding to each reagent as the configuration number of the activation hole sites in the detection area.
In one embodiment, the number of corresponding well locations in the detection zone is determined by: acquiring first activation time of an added reagent required by sample scattering detection; acquiring a second activation time of the added reagent required by the sample transmission detection; obtaining the configuration number of the activation hole sites meeting the scattering detection according to the target detection period and the first activation time; obtaining the configuration number of the activation hole sites meeting the transmission detection according to the target detection period and the second activation time; and determining the larger value of the configuration number of the activation hole sites meeting the scattering detection requirement and the configuration number of the activation hole sites meeting the transmission detection requirement as the configuration number of the activation hole sites in the detection area.
In one embodiment, the number of corresponding wells in the incubation and detection zones is determined by: taking the incubation time, the scattering detection time and the activation time as dividends respectively; taking the target detection period as a divisor; calculating to obtain quotient values corresponding to the incubation time, the scattering detection time and the activation time; respectively determining the quotient values corresponding to the incubation time, the scattering detection time and the activation time as the configuration quantity of the incubation hole sites, the scattering detection hole sites and the activation hole sites;
the configuration number of the transmission detection hole sites is obtained by the following steps: taking the transmission detection time as a dividend; taking the product of the target detection period and the quantity of the reagent required by transmission detection as a divisor; calculating to obtain a quotient value corresponding to the transmission detection time; and determining the quotient corresponding to the transmission detection time as the configuration number of the transmission detection hole sites.
In one embodiment, determining the configured number of incubation well locations in the incubation area according to the target detection period and the target incubation time comprises: calculating a first ratio of the target incubation time to the target detection period; determining the configuration number of incubation hole sites according to the first ratio; determining the configuration number of detection hole sites in the detection area according to the target detection period and the detection time, wherein the configuration number comprises the following steps: and calculating a second ratio of the detection time to the target detection period, and determining the configuration number of the detection hole sites according to the second ratio.
The above-mentioned embodiments only express several embodiments of the present application, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present application. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, which falls within the scope of protection of the present application. Therefore, the protection scope of the present patent shall be subject to the appended claims.
It will be understood by those skilled in the art that all or part of the processes of the methods of the embodiments described above may be implemented by a computer program, which may be stored in a non-volatile computer readable storage medium, and when executed, may include the processes of the embodiments of the methods described above. Any reference to memory, storage, database, or other medium used in the embodiments provided herein may include non-volatile and/or volatile memory, among others. Non-volatile memory can include read-only memory (ROM), Programmable ROM (PROM), Electrically Programmable ROM (EPROM), Electrically Erasable Programmable ROM (EEPROM), or flash memory. Volatile memory can include Random Access Memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in a variety of forms such as Static RAM (SRAM), Dynamic RAM (DRAM), Synchronous DRAM (SDRAM), Double Data Rate SDRAM (DDRSDRAM), Enhanced SDRAM (ESDRAM), Synchronous Link DRAM (SLDRAM), Rambus Direct RAM (RDRAM), direct bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM).
All possible combinations of the technical features in the above embodiments may not be described for the sake of brevity, but should be considered as being within the scope of the present disclosure as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present application, and the description thereof is specific and detailed, but not construed as limiting the scope of the present application. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, which falls within the scope of protection of the present application. Therefore, the protection scope of the present patent application shall be subject to the appended claims. Please enter the implementation details.
Claims (5)
1. A sample analyzer well site configuration method, the sample analyzer comprising: an incubation zone and a detection zone, wherein the method comprises:
acquiring a target detection period of a sample analyzer, wherein the target detection period is a time interval between two adjacent detection results, the target detection period refers to the time for obtaining the output result in the continuous operation of the sample analyzer and does not include incubation time and detection time, the incubation time is the time for heating a sample to reach a required temperature, and the detection time is the time for the sample to stay in a detection channel after the incubation and activation are completed;
obtaining a target incubation time of a standard sample;
determining the configuration number of incubation holes in the incubation area according to the target detection period and the target incubation time, wherein the configuration number comprises the following steps: calculating a first ratio of the target incubation time to the target detection period; determining the configuration number of the incubation hole sites according to the first ratio;
obtaining the detection time of a sample;
determining the configuration number of detection hole sites in the detection area according to the target detection period and the detection time, wherein the configuration number comprises the following steps: calculating a second ratio of the detection time to the target detection period; determining the configuration number of the detection hole sites according to the second ratio; determining the configuration number of scattering detection hole sites in the detection area according to the target detection period and the scattering detection time, and determining the configuration number of transmission detection hole sites in the detection area according to the target detection period and the transmission detection time, wherein the transmission detection time is the total time of detection containing multiple reagents;
the determining the configuration number of the transmission detection hole sites in the detection area according to the target detection period and the transmission detection time comprises: acquiring the quantity of the reagents required to be added for the transmission detection, and determining the configuration quantity of the transmission detection hole sites in the detection area according to the quantity of the reagents, the target detection period and the transmission detection time;
performing hole site configuration on the sample analyzer according to the configuration number of the incubation hole sites and the configuration number of the detection hole sites;
the hole site configuration method further comprises:
acquiring first activation time of an added reagent required by sample scattering detection;
acquiring a second activation time of the added reagent required by the sample transmission detection;
obtaining the configuration number of the activation hole sites meeting the scattering detection according to the target detection period and the first activation time;
obtaining the configuration number of the activation hole sites meeting transmission detection according to the target detection period and the second activation time;
and determining the larger value of the configuration number of the activation hole sites meeting the scattering detection and the configuration number of the activation hole sites meeting the transmission detection as the configuration number of the activation hole sites in the detection area.
2. The method of claim 1, wherein the additional reagent is a plurality, the method further comprising:
acquiring the types of the added reagents and the corresponding activation time of each reagent;
obtaining the configuration number of the activation holes corresponding to each reagent and meeting the requirement according to the target detection period and the activation time corresponding to each reagent;
and determining the configuration number of the activation hole sites which are the largest in the configuration number of the activation hole sites which meet the requirements corresponding to each reagent as the configuration number of the activation hole sites in the detection area.
3. An apparatus for sample analyzer well site configuration, the apparatus comprising:
the first acquisition module is used for acquiring a target detection period of the sample analyzer, wherein the target detection period is a time interval between two adjacent output detection results; the target detection period refers to the time for obtaining an output result after the sample analyzer is continuously operated, and does not include incubation time and detection time, wherein the incubation time is the time for heating the sample to reach the required temperature, and the detection time is the time for the sample to stay in the detection channel after the incubation and activation are completed;
the second acquisition module is used for acquiring the target incubation time of the standard sample;
the first determining module is used for calculating a first ratio of the target incubation time to the target detection period and determining the configuration number of incubation hole sites in the incubation area according to the first ratio;
the third acquisition module is used for acquiring the detection time of the sample;
the second determining module is used for calculating a second ratio of the detection time to the target detection period and determining the configuration number of the detection hole positions in the detection area according to the second ratio; determining the configuration number of scattering detection hole sites in the detection area according to the target detection period and the scattering detection time, and determining the configuration number of transmission detection hole sites in the detection area according to the target detection period and the transmission detection time; the transmission detection time is the total time of detection comprising the plurality of reagents;
the second determining module is specifically configured to obtain the number of reagents required to be added for the transmission detection, and determine the configuration number of transmission detection holes in the detection area according to the number of reagents, the target detection period, and the transmission detection time;
the configuration module is used for configuring the hole sites of the sample analyzer according to the configuration number of the incubation hole sites and the configuration number of the detection hole sites;
the fifth acquisition module is used for acquiring the first activation time of the added reagent required by the sample scattering detection; acquiring a second activation time of the added reagent required by the sample transmission detection;
a fourth determining module, configured to obtain the configuration number of the activation hole sites satisfying the scattering detection according to the target detection period and the first activation time; obtaining the configuration number of the activation hole sites meeting transmission detection according to the target detection period and the second activation time; and determining the larger value of the configuration number of the activation hole sites meeting the scattering detection and the configuration number of the activation hole sites meeting the transmission detection as the configuration number of the activation hole sites in the detection area.
4. A computer device comprising a memory and a processor, wherein the memory has stored therein a computer program, and wherein the processor is adapted to invoke the computer program in the memory to perform the steps of the method according to any of claims 1 to 2.
5. A sample analyzer comprising an incubation zone and a detection zone, wherein the sample analyzer further comprises a sample analyzer well placement device according to claim 3.
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