CN112870533B - Medicine carrying microsphere preparation device - Google Patents

Abstract

The invention relates to a drug-loaded microsphere preparation device, which comprises a suspension generation module and a screening module, wherein the screening module comprises a cavity, a spraying unit, a primary filtering unit and a secondary filtering unit, wherein: the baffle is arranged in the cavity and divides the cavity into an upper cavity and a lower cavity; one end of the spraying unit is communicated with the suspension generation module, and the other end of the spraying unit extends into the upper chamber and sprays suspension along the lower chamber towards the upper chamber; the primary filtering unit is arranged on one side, away from the lower chamber, of the spraying unit in the upper chamber, is communicated with the lower chamber in a diversion way and is used for separating a first filtering liquid with the particle size not larger than a first set value; the secondary filtering unit is arranged in the lower chamber, is positioned at one side of the liquid outlet of the first filtering liquid, which is far away from the baffle, and is used for separating the drug-loaded microspheres with the particle size not less than a second set value; drug-loaded microspheres with uniform particle sizes are screened out through a simpler structure and a twice separation process, so that blockage caused by microsphere accumulation is avoided, and large-batch screening and production are realized.

Description

Medicine carrying microsphere preparation device

Technical Field

The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation device of drug-loaded microspheres.

Background

In recent years, with the rapid development of the pharmaceutical industry and the continuous development and improvement of medicament technology and materials by people, the sustained-release preparation serving as a novel medicament dosage form can improve the action effect of medicaments and has great development and application prospects, and the medicament-carrying microspheres become a hot point direction for the research and development of the sustained-release preparation due to the advantages of reducing the administration frequency, maintaining stable blood concentration, reducing toxic and side effects and the like.

The drug-loaded microspheres are a micro drug delivery system for dissolving, dispersing, adsorbing or coating drugs in a high-molecular framework material, can control the release rate of the drugs, improve the stability of the drugs and change the action effect of the drugs. At present, the preparation method of the drug-loaded microsphere mainly comprises a phase separation method, a spray drying method, an electrostatic spray method, an emulsion crosslinking method and a solvent evaporation method, but a solvent used by the phase separation method is very difficult to remove from the drug-loaded microsphere, and the problem of solvent residue exists; the spray drying method and the electrostatic spraying method are not suitable for drug-loaded micro-spheroidization of temperature-sensitive compounds, and the particle size of the formed drug-loaded microspheres is difficult to control; the emulsion crosslinking method has long preparation time, is greatly influenced by external environment and is not suitable for large-scale preparation; compared with the methods, the solvent volatilization method is the most extensive method for preparing the drug-loaded microspheres at present, the particle size and the form of the drug-loaded microspheres are adjusted by controlling the stability and the form of emulsion droplets, but the emulsion droplets are difficult to control, the particle size is difficult to adjust, the product quality is difficult to control due to uneven particle size of the drug-loaded microspheres, the drug stability of the drug-loaded microspheres is poor, the production process is complex, the drug-loaded microspheres are easily influenced by the environment, and the batch production is not convenient.

Disclosure of Invention

Therefore, it is necessary to provide a drug-loaded microsphere preparation device for solving the problems of uneven particle size and difficulty in mass production of the drug-loaded microspheres.

The utility model provides a medicine carrying microsphere preparation facilities, includes suspension generation module and screening module, the screening module includes cavity, spraying unit, one-level filter unit, second grade filter unit, wherein:

a baffle is arranged in the cavity and divides the cavity into an upper cavity and a lower cavity;

one end of the spraying unit is communicated with the suspension generation module, and the other end of the spraying unit extends into the upper chamber and sprays suspension along the lower chamber towards the upper chamber;

the primary filtering unit is arranged on one side, away from the lower chamber, of the spraying unit in the upper chamber, is communicated with the lower chamber in a diversion way, and is used for separating a first filtering liquid with the particle size not larger than a first set value;

the second grade filter unit sets up in the lower chamber, and is located the liquid outlet of first filtrate is kept away from one side of baffle for the medicine carrying microballon that the separation particle diameter is not less than the second setting value.

In one embodiment, the primary filtering unit comprises a first container and a first micro-filtration membrane, the first container is fixed on the inner wall of the upper chamber, and one side of the first container facing the spraying unit is provided with an opening, and the first micro-filtration membrane is fixed on one side of the first container facing the spraying unit and has a pore size of the first set value.

In one embodiment, the first container is in diversion communication with the lower chamber through a pumping unit, the pumping unit is provided with a first diversion pipe, one end of the first diversion pipe extends into the upper chamber and is communicated with the first container, the other end of the first diversion pipe extends into the lower chamber, and the first diversion pipe is positioned on one side, close to the baffle, of the secondary filtering unit.

In one embodiment, the secondary filtering unit comprises a second container and a second microfiltration membrane, the second container is arranged on the inner wall of the lower chamber and is provided with a microcavity penetrating through the thickness of the second container, the aperture of the microcavity is not smaller than the second set value, the second microfiltration membrane is detachably arranged on one side, facing the baffle, of the second container, and the aperture is the second set value.

In one embodiment, the second container is rotatably disposed on an inner wall of the lower chamber, a partition plate protrudes from one side of the second container facing the baffle plate, the partition plate extends below the liquid outlet of the first filtrate, and divides a space between the baffle plate and the second container into at least two accommodating cavities, the liquid outlet of the first filtrate is located in the accommodating cavities, and the second microfiltration membrane is clamped on a part of the second container in each accommodating cavity.

In one embodiment, the screening module further comprises a third microfiltration membrane, the third microfiltration membrane is arranged in the upper chamber and located on one side of the spraying unit far away from the primary filtering unit, and the third microfiltration membrane has the same filtering pore size as the first microfiltration membrane and is used for separating the first filtrate.

In one embodiment, the screening module further comprises a fourth microfiltration membrane, the fourth microfiltration membrane is arranged in the upper chamber and located on one side of the third microfiltration membrane away from the spraying unit, and the filtering pore size of the fourth microfiltration membrane is the same as that of the second microfiltration membrane, so that the drug-loaded microspheres are separated.

In one embodiment, the medicine carrying microsphere preparation device further comprises a second flow guide pipe, one end of the second flow guide pipe extends into the upper cavity and is arranged on the baffle, the other end of the second flow guide pipe extends into the lower cavity, and the second-stage filtering unit is located close to one side of the baffle.

In one embodiment, the drug-loaded microsphere preparation device further comprises a first collection unit and a second collection unit, wherein one end of the first collection unit extends into the upper cavity and is arranged on the baffle, and one end of the second collection unit is inserted into the through groove in the bottom wall of the lower cavity.

In one embodiment, medicine carrying microsphere preparation facilities still includes the backward flow module, the backward flow module includes condensation unit and purification unit, the condensation unit with suspension generates the module and is linked together for collect and condense steam, the one end of purification unit with the condensation unit is linked together, the other end with suspension generates the module and is linked together for purify and carry organic solvent.

Has the advantages that:

1. in the medicine carrying microsphere preparation device, suspension generated by the suspension generation module is input from one end of the spraying unit and reversely sprayed from the other end of the spraying unit towards the upper cavity along the direction of the lower cavity towards the upper cavity towards the primary filtering unit, the suspension is firstly separated and separated into two parts at the primary filtering unit, microspheres with the particle sizes larger than a first set value cannot pass through and fall back to the baffle, first filtering liquid with the particle sizes not larger than the first set value remains at the primary filtering unit and is guided into the lower cavity through the primary filtering unit, the first filtering liquid is sprayed towards the secondary filtering unit from the liquid outlet, secondary separation is performed at the secondary filtering unit, medicine carrying microspheres with the particle sizes not smaller than a second set value cannot pass through and remain above the secondary filtering unit, the medicine carrying microspheres are screened, and the preparation process is simple, convenient and easy to operate.

2. The prepared drug-loaded microspheres have the particle size between a first set value and a second set value, and the drug-loaded microspheres with uniform particle size are screened out through a simpler structure and process.

3. Because the suspension is reversely sprayed towards the first-stage filtering unit along the direction of the lower cavity towards the upper cavity, the microspheres with the particle sizes larger than the first set value cannot pass through, so that the blockage caused by the accumulation of part of microspheres in the first-stage filtering unit when the filtration capacity of the suspension is large is avoided, a large amount of suspensions can be filtered, and the mass screening and mass production are realized.

4. Be provided with the backward flow module in the above-mentioned medicine carrying microsphere preparation facilities, can retrieve and recycle organic solvent, can avoid the waste of resource on the one hand, save the cost, on the other hand can also avoid steam direct discharge to air polluted air to the environmental protection.

Drawings

Fig. 1 is a schematic structural diagram of a drug-loaded microsphere preparation device provided by the invention;

fig. 2 is a schematic structural diagram of a screening module in a drug-loaded microsphere preparation device provided by the invention;

fig. 3 is a schematic structural diagram of a screening module in another drug-loaded microsphere preparation device provided by the invention;

fig. 4 is a schematic structural diagram of a screening module in another drug-loaded microsphere preparation device provided by the invention;

fig. 5 is a schematic structural diagram of a screening module in another drug-loaded microsphere preparation device provided by the invention;

fig. 6 is a schematic structural diagram of another drug-loaded microsphere preparation device provided by the invention;

fig. 7 is a schematic structural view of another drug-loaded microsphere preparation device provided by the invention;

FIG. 8 is a photograph of the microsphere obtained by the prior art under a scanning electron microscope;

fig. 9 is a shape photograph of a drug-loaded microsphere of the drug-loaded microsphere preparation device under a scanning electron microscope.

Reference numerals:

10. a drug-loaded microsphere preparation device;

100. a suspension generation module; 110. an emulsion reaction module; 120. a blender; 130. an oil phase proportioning unit; 140. a water phase proportioning unit; 150. an oil phase titration speed control unit;

200. a screening module; 210. a cavity; 211. a baffle plate; 212. an upper chamber; 213. a lower chamber; 220. a spray unit; 221. a liquid suction unit; 222. a pressurizing unit; 223. a spray head; 230. a primary filtration unit; 231. a first container; 2311. an opening; 232. a first microfiltration membrane; 240. a secondary filtration unit; 241. a second container; 2411. a microcavity; 242. a second microfiltration membrane; 243. a partition plate; 244. an accommodating cavity; 250. a suction unit; 251. a first draft tube; 260. a third microfiltration membrane; 270. a fourth microfiltration membrane; 280. a second draft tube;

300. a first collecting unit;

400. a second collection unit;

500. a reflow module;

510. a condensing unit; 520. a purification unit; 530. a first receiving unit; 540. a second receiving unit; 550. an additional unit; 560. an extraction unit;

20. suspension; 21. carrying a drug microsphere; 22. a first microsphere; 23. a second microsphere; 24. a first filtrate; 25. and (4) filtering the second filtrate.

Detailed Description

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the invention.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.

In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.

It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like as used herein are for illustrative purposes only and do not denote a unique embodiment.

The technical scheme provided by the embodiment of the invention is described below by combining the accompanying drawings.

As shown in fig. 1, the invention provides a drug-loaded microsphere preparation device 10, the drug-loaded microsphere preparation device 10 is used for preparing drug-loaded microspheres 21 by a solvent volatilization method, and the particle size of the drug-loaded microspheres 21 is changed in a small range, so that the particle size of the drug-loaded microspheres 21 is uniform. The drug-loaded microsphere preparation device 10 comprises a suspension generation module 100 and a screening module 200, wherein the screening module 200 comprises a cavity 210, a spraying unit 220, a primary filtering unit 230 and a secondary filtering unit 240, wherein:

as shown in fig. 2 and 3, the suspension generation module 100 includes an emulsion reaction module 110, and a stirrer 120, an oil phase proportioning unit 130, a water phase proportioning unit 140, and an oil phase titration speed control unit 150 inserted into the emulsion reaction module 110; wherein, the stirrer 120 is provided with a touch panel which can adjust the stirring speed and control the mixing speed of the oil phase and the water phase in the whole process, and the stirring speed of the stirrer 120 can be 100Rpm-20000 Rpm; the oil phase proportioning unit 130 and the water phase proportioning unit 140 may be configured to be fully automatic; the oil phase proportioning unit 130 is internally provided with one or more synergistic medicines and corresponding polymer carriers, and the oil phase proportioning unit 130 comprises an automatic filling mechanism, a control system and at least three preparation containers connected with the automatic filling mechanism and the control system, and is used for automatically filling materials and automatically measuring organic solvents, polymers, medicines and the like; the oil phase proportioning unit 130 adjusts the titration speed of the oil phase through an oil phase titration speed control unit 150 arranged on a pipeline between the oil phase proportioning unit 130 and the emulsion reaction module 110, wherein the oil phase titration speed control unit 150 can be a touch control adjusting button, and the speed control range is 0.01-50 ml/min; the water phase proportioning unit 140 is internally provided with water, an emulsifier and other additives, and comprises a raw material loading container and a weighing mechanism connected with the raw material loading container, so that the components can be accurately measured and fully and uniformly mixed, the error is small, and the efficiency is high; after oil phase in the emulsion reaction module 110 is dripped, a certain amount of aqueous solvent and a certain proportion of emulsifier are added, emulsion reaction is carried out at a certain rotating speed and temperature, along with stirring in the reaction process, in the whole process, the organic solvent gradually volatilizes along with the stirring to form a suspension 20, microspheres in the suspension 20 comprise first microspheres 22 with the particle size larger than a first set value, second microspheres 23 with the particle size smaller than a second set value and required target drug-carrying microspheres 21, and the particle size of the drug-carrying microspheres 21 is between the first set value and the second set value.

As shown in fig. 1, a baffle 211 is disposed in the cavity 210, the baffle 211 is fixedly disposed on the cavity 210, the baffle 211 and the cavity 210 may be integrally formed, for example, manufactured by a casting process, the baffle 211 may be fixed on the cavity 210 by a snap connection, a concave-convex fit, or the like at a later stage, the baffle 211 is disposed at a set height inside the cavity 210, and divides the cavity 210 into an upper chamber 212 and a lower chamber 213, and when the cavity 210 is placed on a horizontal plane, the upper chamber 212 and the lower chamber 213 are sequentially arranged from top to bottom.

As shown in fig. 1, one end of the spraying unit 220 is in communication with the suspension-generating module 100, and in particular, the spraying unit 220 is in communication with the suspension-generating module 100 through a pipe, and a suction unit 221, e.g., a suction pressure pump, is mounted on the pipe so as to suck the suspension 20 from the suspension-generating module 100 into the pipe, and a pressurizing unit 222, e.g., a pressurizing pump, is disposed on the side of the pipe on which the suction unit 250 is close to the chamber 210 so as to pressurize the suspension 20 so as to spray from the spraying unit 220. The other end of the spraying unit 220 extends into the upper chamber 212, and the spraying unit 220 sprays the suspension 20 in the direction of the upper chamber 212 along the lower chamber 213, and when the arrangement is specific, the spray head 223 of the spraying unit 220 may be arranged in the middle area of the upper chamber 212, for example, the spray head 223 is located at the center of the upper chamber 212, so that the spraying area of the suspension 20 is larger, and in order to further increase the spraying area, the spraying unit 220 may be in the form of an umbrella structure, for example, the umbrella-shaped spray head 223 is adopted, so that the spraying area in the form of a conical surface can be formed.

As shown in fig. 1, the primary filter unit 230 is disposed inside the upper chamber 212 and located on one side of the spraying unit 220 away from the lower chamber 213, when the primary filter unit 230 is specifically disposed, the primary filter unit 230 may be detachably connected inside the upper chamber 212 in a snap connection, a concave-convex fit, or the like, the primary filter unit 230 may also be fixed inside the upper chamber 212 in a welding manner, or the like, the primary filter unit 230 is located at a set height on one side of the spraying unit 220 away from the lower chamber 213, and the specific disposition form of the primary filter unit 230 may be determined according to the actual situation of the drug-loaded microsphere preparation apparatus 10. The primary filtering unit 230 is in flow guide communication with the lower chamber 213, the primary filtering unit 230 is used for separating a first filtering liquid 24 with a particle size not larger than a first set value, the first filtering liquid 24 contains second microspheres 23 and drug-loaded microspheres 21, when the primary filtering unit is specifically arranged, the suspension 20 is firstly separated and separated into two parts at the primary filtering unit 230, the first microspheres 22 cannot fall back to the baffle 211, and the first filtering liquid 24 remains in the primary filtering unit 230 and is guided into the lower chamber 213 through the primary filtering unit 230.

As shown in fig. 1, the secondary filtering unit 240 is disposed in the lower chamber 213, the secondary filtering unit 240 is located at a side of the liquid outlet of the first filtrate 24 away from the baffle 211, and when the secondary filtering unit 240 is specifically disposed, the secondary filtering unit 240 may be detachably connected to the inside of the lower chamber 213 by means of a snap connection, a concave-convex fit, and the like, and the secondary filtering unit 240 is located at a set height of the side of the liquid outlet of the first filtrate 24 away from the baffle 211, and the specific disposition form of the secondary filtering unit 240 may be determined according to the actual situation of the drug-loaded microsphere preparation apparatus 10. The secondary filtering unit 240 is used for separating the drug-loaded microspheres 21 with the particle size not smaller than a second set value, when the device is specifically set, the first filtering liquid 24 is sprayed from the liquid outlet toward the secondary filtering unit 240, and is separated into two parts at the secondary filtering unit 240 for the second time, the drug-loaded microspheres 21 cannot pass through the upper part of the secondary filtering unit 240, and the second filtering liquid containing the second microspheres 23 flows to the bottom of the lower chamber 213 after passing through the secondary filtering unit 240.

In the device 10 for preparing drug-loaded microspheres, the suspension 20 generated by the suspension generating module 100 is input from one end of the spraying unit 220 and is reversely sprayed from the other end toward the primary filtering unit 230 along the direction from the lower chamber 213 to the upper chamber 212, the suspension 20 is first separated and separated into two parts at the primary filtering unit 230, microspheres with a particle size larger than a first set value cannot pass through and fall back to the baffle 211, the first filtrate 24 with a particle size not larger than the first set value remains in the primary filtering unit 230 and is guided into the lower chamber 213 through the primary filtering unit 230, the first filtrate 24 is sprayed toward the secondary filtering unit 240 from a liquid outlet and is second separated at the secondary filtering unit 240, and the drug-loaded microspheres 21 with a particle size not smaller than a second set value cannot pass through and remain above the secondary filtering unit 240, so as to realize the screening of the drug-loaded microspheres 21, and at this moment, the particle size of the drug carrying microspheres 21 is between the first set value and the second set value, the drug carrying microspheres 21 with uniform particle size are screened out through a simpler structure and process, in addition, because the suspension 20 is reversely sprayed towards the primary filtering unit 230 along the direction from the lower cavity 213 to the upper cavity 212, the microspheres with the particle size larger than the first set value cannot pass through, so that the blockage caused by the accumulation of part of microspheres in the primary filtering unit 230 when the filtration capacity of the suspension 20 is large is avoided, a large amount of suspensions 20 can be filtered, and the mass screening and mass production are realized.

The primary filter unit 230 has various structures, as shown in fig. 1, in a preferred embodiment, the primary filter unit 230 includes a first container 231 and a first micro filtration membrane 232, the first container 231 may be fixed on the inner wall of the upper chamber 212 by means of snap connection, male-female fit, screw connection, etc., the first container 231 is hollow inside, and one side of the first container 231 facing the spraying unit 220 has an opening 2311, the number of the openings 2311 is plural, the plural openings 2311 are uniformly arranged on the surface of the first container 231 facing the spraying unit 220, each opening 2311 communicates with the inside of the first container 231, the liquid entering from the opening 2311 is contained inside the first container 231, the first micro filtration membrane 232 is fixed on one side of the first container 231 facing the spraying unit 220 by means of snap connection, screw connection, etc., the first micro filtration membrane 232 is supported by the first container 231, and the pore size of the first micro-filtration membrane 232 is a first set value.

In the device 10 for preparing drug-loaded microspheres, the spraying unit 220 sprays the suspension 20 in the reverse direction toward the first microporous filtration membrane 232 along the direction from the lower chamber 213 to the upper chamber 212, the particle size of the first microspheres 22 is greater than a first set value and cannot pass through the pore size of the first microporous filtration membrane 232, the first microspheres 22 directly fall back onto the baffle 211 under the action of gravity, the particle size of each microsphere in the first filtrate 24 is not greater than the first set value, and the first filtrate 24 enters the first container 231 from the opening 2311 through the pore size of the first microporous filtration membrane 232, so that the suspension 20 can be first separated at the primary filtration unit 230 simply and conveniently by limiting the structure of the primary filtration unit 230, and is separated into the first microspheres 22 and the first filtrate 24. And the suspension 20 is reversely sprayed towards the first microporous filtering membrane 232, so that compared with the traditional forward downward spraying, the accumulation of microspheres in the filtering holes can be reduced, the blockage is avoided, the deposited impurities can be prevented from continuously entering the secondary filtering unit 240, and the filtering effect is improved. When the filtering device is specifically arranged, the first microfiltration membrane 232 may be an SPG membrane (a Shirasu Porous Glass membrane), the first microfiltration membrane 232 may also be in other structural forms capable of meeting the filtering requirements, the first container 231 may be an elongated cavity 210, openings 2311 are uniformly distributed on one side of the elongated cavity 210, and the first container 231 may also be in other structural forms capable of supporting and storing functions. Of course, the structure of the primary filtering unit 230 is not limited to the structure of the first container 231 and the first microfiltration membrane 232, and may be in other structures capable of satisfying the filtering and storing functions.

To facilitate fluid communication between the primary filter unit 230 and the lower chamber 213, as shown in fig. 1, specifically, the first container 231 is in fluid communication with the lower chamber 213 via a pumping unit 250, e.g., a suction pressure pump, and the pumping unit 250 facilitates pumping the first filtrate 24 from the first container 231 into the lower chamber 213. The pumping unit 250 has a first guide tube 251, one end of the first guide tube 251 extends into the upper chamber 212, and the first guide tube 251 is communicated with the first container 231, and the other end of the first guide tube 251 extends into the lower chamber 213, and the other end of the first guide tube 251 is positioned at a side of the secondary filtering unit 240 close to the baffle 211, so that the first filtrate 24 is sprayed downward.

In the above drug-loaded microsphere preparation device 10, the suction unit 250 communicates the first container 231 and the lower chamber 213, and allows the first filtrate 24 to perform a suction function. The first filtered liquid 24 is retained in the first vessel 231, and the first filtered liquid 24 is sucked from the first vessel 231 into one end of the first flow guide tube 251 and is ejected from the other end of the first flow guide tube 251 to enter the lower chamber 213. Therefore, the first filtrate 24 in the upper chamber 212 can be transferred to the lower chamber 213 and sprayed out of the lower chamber 213 through the pumping unit 250. In a specific arrangement, the first container 231 may be in flow-guide communication with the lower chamber 213 through the pumping unit 250, and the flow-guide communication between the primary filtering unit 230 and the lower chamber 213 may also be in other forms that can meet the requirements.

The structure of the secondary filtering unit 240 has various structures, as shown in fig. 1, in a preferred embodiment, the secondary filtering unit 240 includes a second container 241 and a second micro-porous filtering membrane 242, the second container 241 can be disposed on the inner wall of the lower chamber 213 by means of snap connection, male-female fit, screw connection, etc., and the second container 241 has a micro-cavity 2411, the micro-cavity 2411 penetrates through the thickness of the second container 241, the number of the micro-cavities 2411 is plural, the plural micro-cavities 2411 are uniformly arranged on the second container 241, and the pore diameter of the micro-cavity 2411 is smaller than or equal to a second set value. The aperture of the second microporous filtering membrane 242 is a second set value, the second microporous filtering membrane 242 is installed on one side of the second container 241 facing the baffle 211, the second microporous filtering membrane 242 is supported by the second container 241, and the second microporous filtering membrane 242 can be detached from the second container 241, when specifically installed, the second microporous filtering membrane 242 can be fixed on the second container 241 by mechanical connection methods such as snap connection, concave-convex fit, threaded connection, and the like, and the micro-cavity 2411 is arranged opposite to the filtering holes of the second microporous filtering membrane 242.

In the device 10 for preparing drug-loaded microspheres, the first filtrate 24 is sprayed towards the second microporous filtering membrane 242 from the liquid outlet, the particle size of the drug-loaded microspheres 21 is between the first set value and the second set value, and cannot pass through the pore size of the second microporous filtering membrane 242 and remain above the second microporous filtering membrane 242, the particle size of the second microspheres 23 is smaller than the second set value, and the second filtrate including the second microspheres 23 passes through the pore size of the second microporous filtering membrane 242, enters the microcavity 2411, and flows to the bottom of the lower chamber 213 after passing through the microcavity 2411. Therefore, the second separation of the first filtered liquid 24 at the secondary filtering unit 240 can be performed simply and conveniently by defining the structure of the secondary filtering unit 240, and the first filtered liquid is separated into two parts, namely the drug-loaded microspheres 21 and the second filtered liquid. When the specific arrangement is carried out, the second microfiltration membrane 242 can be an SPG membrane (Shirasu Porous Glass membrane), the second microfiltration membrane 242 can also be other structural forms capable of meeting the filtration requirements, the second container 241 can be a strip-shaped plate body, openings 2311 are uniformly distributed on one side of the strip-shaped cavity 210, and the second container 241 can also be other structural forms capable of supporting and guiding the flow. Of course, the structure of the primary filtering unit 230 is not limited to the structure of the second container 241 and the second microporous filtering membrane 242, and may be other structures capable of satisfying the filtering and flow guiding functions. Through changing first microfiltration membrane 232 and the second microfiltration membrane 242 in different apertures, carry out the filtration of different particle size scopes, can realize the screening of the medicine carrying microsphere 21 of different particle sizes for above-mentioned medicine carrying microsphere preparation facilities 10's commonality is better, and it is less to receive the environmental impact, can make things convenient for the mass production of medicine carrying microsphere 21.

In order to reduce the clogging of the secondary filter unit 240, as shown in fig. 4, specifically, the second container 241 is rotatably disposed on the inner wall of the lower chamber 213, and in the specific arrangement, the second container 241 overlaps the boss on the inner wall of the lower chamber 213, and the second container 241 is connected to a driving module, which drives the second container 241 to rotate around its axis, the driving module may be disposed inside the second container 241 or on a side of the second container 241 near the bottom of the lower chamber 213. The second container 241 is provided with a partition 243 protruding from a side facing the baffle 211, the partition 243 may be integrally formed with the second container 241, for example, by casting, and the partition 243 may be fixed on a surface of the second container 241 facing the baffle 211 by means of snap connection, male-female fit, or screw connection. The partition 243 extends below the liquid outlet of the first filtrate 24, and a certain distance is provided between the partition 243 and the liquid outlet of the first filtrate 24, so as to avoid interference between the partition 243 and the liquid outlet of the first filtrate 24 when the second container 241 rotates. The partition 243 divides the space between the baffle 211 and the second container 241 into at least two accommodating chambers 244, the number of the accommodating chambers 244 may be two, three, four or more, and the accommodating chambers 244 are uniformly arranged in the circumferential direction of the second container 241. The outlet of the first filtrate 24 is located in the accommodating cavities 244, and a part of the second container 241 in each accommodating cavity 244 is clamped with the second microporous filter membrane 242, however, the fixing manner of the second microporous filter membrane 242 is not limited to the above clamping, and may be other forms capable of meeting the requirements.

In the above drug-loaded microsphere preparation apparatus 10, the liquid outlet of the first filtrate 24 is located in an accommodating chamber 244, the first filtrate 24 is sprayed toward the second microporous filtering membrane 242 in the accommodating chamber 244, the drug-loaded microspheres 21 are retained above the second microporous filtering membrane 242, the second filtrate enters the microcavity 2411 after passing through the aperture of the second microporous filtering membrane 242, the first filtrate 24 is continuously sprayed with the liquid, the drug-loaded microspheres 21 above the second microporous filtering membrane 242 are gradually increased, after the drug-loaded microspheres 21 are accumulated to a certain thickness, in order to prevent the accumulated drug-loaded microspheres 21 from blocking the filter holes of the second microporous filtering membrane 242, the second container 241 is rotated to a certain angle, the accommodating chamber 244 rotates, the liquid outlet of the first filtrate 24 is transferred to another accommodating chamber 244, the drug-loaded microspheres 21 are not present above the second microporous filtering membrane 242 in the accommodating chamber 244, the filtration and screening operation is continuously performed, and after all the drug-loaded microspheres 21 are uniformly distributed in the accommodating chamber 244, and the second microporous filtration membrane 242 is cleaned or replaced for the next filtration and screening cycle. Therefore, the structure of the secondary filtering unit 240 can avoid the blockage of the filtering holes, improve the filtering efficiency and further obtain the drug-loaded microspheres 21 with uniform particle size. In particular arrangements, the partition 243 may include a support column to which the spacer is removably attached and a plurality of spacers that are secured to the second container 241. Of course, the structure of the secondary filter unit 240 is not limited to the above-mentioned form, and may be other structural forms capable of meeting the requirements.

In order to improve the filtering efficiency, as shown in fig. 5, in a preferred embodiment, the sieving module 200 further includes a third microfiltration membrane 260, the third microfiltration membrane 260 is disposed in the upper chamber 212 by means of screw connection, concave-convex fit, and the like, and the third microfiltration membrane 260 is located at a side of the spraying unit 220 away from the primary filtering unit 230, the third microfiltration membrane 260 has a certain distance from the spraying unit 220 and the baffle 211, the third microfiltration membrane 260 has the same filtering pore size as the first microfiltration membrane 232, and the third microfiltration membrane 260 is used for separating the first filtrate 24.

In the above drug-loaded microsphere preparation apparatus 10, the suspension 20 is reversely ejected toward the first microporous filtration membrane 232 along the direction from the lower chamber 213 to the upper chamber 212, a part of the suspension 20 and the microparticles directly fall under the action of gravity and cannot reach the first microporous filtration membrane 232, the part of the suspension 20 and the microparticles fall back onto the third microporous filtration membrane 260, the first microspheres 22 cannot directly remain on the first microporous filtration membrane 232 through the aperture of the third microporous filtration membrane 260, and the first filtrate 24 flows downward through the aperture of the third microporous filtration membrane 260, so that the suspension 20 and the microspheres which cannot reach the first microporous filtration membrane 232 can be first separated simply and conveniently by limiting the third microporous filtration membrane 260, and are separated into the first microspheres 22 and the first filtrate 24, and then the first filtrate 24 is treated, so as to avoid missing the drug-loaded microspheres 21, the filtration efficiency and the recovery efficiency are improved. In a specific configuration, the third microfiltration membrane 260 may be an SPG (Shirasu Porous Glass membrane), and the third microfiltration membrane 260 may also be in other structural forms capable of meeting the filtration requirements. The structure capable of separating the suspension 20 and the microspheres which cannot reach the first microfiltration membrane 232 for the first time is not limited to the third microfiltration membrane 260, and may be other structure capable of satisfying the requirement, for example, the third microfiltration membrane 260 is combined with a support plate having through holes.

In order to further improve the filtering efficiency, as shown in fig. 6, specifically, the sieving module 200 further includes a fourth micro-filtration membrane 270, the fourth micro-filtration membrane 270 is disposed in the upper chamber 212 by means of screw connection, concave-convex fit, and the like, and the fourth micro-filtration membrane 270 is located on a side of the third micro-filtration membrane 260 away from the spraying unit 220, the fourth micro-filtration membrane 270 is located at a certain distance from the third micro-filtration membrane 260 and the baffle 211, the filtering pore diameter of the fourth micro-filtration membrane 270 is the same as that of the second micro-filtration membrane 242, and the fourth micro-filtration membrane 270 is used for separating the drug-loaded microspheres 21.

In the drug-loaded microsphere preparation device 10, after the suspension 20 and the microspheres which cannot reach the first microfiltration membrane 232 are separated for the first time by the third microfiltration membrane 260, the first microspheres 22 and impurities are retained on the third microfiltration membrane 260, the first filtrate 24 flows downwards to the fourth microfiltration membrane 270 after passing through the aperture of the third microfiltration membrane 260, the drug-loaded microspheres 21 cannot pass through the aperture of the fourth microfiltration membrane 270 and are retained above the fourth microfiltration membrane 270, and the second filtrate comprising the second microspheres 23 flows to the bottom of the upper chamber 212 after passing through the fourth microfiltration membrane 270. Therefore, the first filtrate 24 can be simply and conveniently separated for the second time at the fourth microporous filtering membrane 270 by limiting the fourth microporous filtering membrane 270, and the first filtrate is separated into two parts, namely the drug-loaded microspheres 21 and the second filtrate, so that the filtering efficiency and the recovery efficiency are improved. In a specific configuration, the fourth microfiltration membrane 270 may be an SPG (Shirasu Porous Glass membrane), and the fourth microfiltration membrane 270 may also be in other structural forms capable of meeting the filtration requirements. The structure capable of secondarily separating the suspension 20 and the microspheres which cannot reach the first microfiltration membrane 232 is not limited to the fourth microfiltration membrane 270, and other structures capable of satisfying the requirements, for example, the fourth microfiltration membrane 270 is combined with a support plate having through holes.

In order to further improve the filtering efficiency, as shown in fig. 7, in particular, the sieving module 200 further includes a second flow duct 280, one end of the second flow duct 280 extends into the upper chamber 212, and the one end of the second flow duct 280 may be disposed on the baffle 211 by means of embedding or clamping, and the other end of the second flow duct 280 extends into the lower chamber 213, and the other end of the second flow duct 280 is located at one side of the secondary filtering unit 240 close to the baffle 211, so as to facilitate the first filtrate 24 to be sprayed downwards.

In the drug-loaded microsphere preparation apparatus 10, due to the limitation of the space of the upper chamber 212, the fourth microporous filtering membrane 270 may not be disposed in the upper chamber 212, but the first filtrate 24 separated by the third microporous filtering membrane 260 is guided into the lower chamber 210 to be separated on the second microporous filtering membrane 242 for the second time. The second flow tube 280 communicates the upper chamber 212 and the lower chamber 213, and the first filtrate 24 enters one end of the second flow tube 280 from the baffle 211 and is sprayed out of the other end of the second flow tube 280 to enter the lower chamber 213. In a specific arrangement, the configuration that allows the flow-through and communication between the upper chamber 212 and the lower chamber 213 is not limited to the second flow guide pipe 280, and may be the suction unit 250, or may be another configuration that can satisfy the requirement.

In order to improve the resource utilization and flexibility, as shown in fig. 3, fig. 4, fig. 5, fig. 6 and fig. 7, in a preferred embodiment, the drug-loaded microsphere preparation apparatus 10 further includes a first collection unit 300 and a second collection unit 400, one end of the first collection unit 300 extends into the upper chamber 212, and the one end of the first collection unit 300 is disposed on the baffle 211, the first collection unit 300 is used for collecting the suspension 20 and microspheres which cannot reach the first microporous filtration membrane 232, one end of the second collection unit 400 is inserted into the through groove on the bottom wall of the lower chamber 213, and the second collection unit 400 is used for collecting the second filtrate.

In the drug-loaded microsphere preparation device 10, the suspension 20 is reversely sprayed towards the primary filtering unit 230 along the direction from the lower chamber 213 to the upper chamber 212, the suspension 20 and the microspheres which cannot reach the primary filtering unit 230 directly fall onto the baffle 211 under the action of gravity, enter one end of the first collecting unit 300 from the baffle 211, and are collected by the first collecting unit 300, so that subsequent operations, such as re-separation, are performed, the resource utilization rate is improved, and waste is avoided. The drug-loaded microspheres 21 remain on the secondary filtering unit 240 after the first filtrate 24 is separated by the secondary filtering unit 240, the particle size of the second microspheres 23 is smaller than a second set value, the second filtrate including the second microspheres 23 flows to the bottom of the lower chamber 213, enters one end of the second collecting unit 400 from the bottom of the lower chamber 213, and is collected by the second collecting unit 400, so as to perform subsequent operations, such as re-separation, thereby improving the resource utilization rate and avoiding waste. When specifically arranged, the first collection unit 300 and the second collection unit 400 may be a liquid storage tank with a suction function, or may be in other structural forms capable of meeting requirements. The first collection unit 300 is adapted to collect the second filtrate when the third microfiltration membrane 260 and the fourth microfiltration membrane 270 are present, and the first collection unit 300 is adapted to collect the first filtrate 24 when the third microfiltration membrane 260 is present. Of course, it is not limited to the first collection unit 300 and the second collection unit 400, and a third collection unit connected to the primary filtration unit 230 may be provided and controlled by a valve to switch between directly performing the second separation and transferring to another pipeline, or a fourth collection unit may be provided directly on the emulsion reaction module 110 and controlled by a valve to switch between performing the second separation and transferring to another pipeline.

In order to solve the problems of low resource utilization rate caused by evaporation of organic solvent in the production process and environmental pollution caused by the evaporation of organic solvent, as shown in fig. 2 and 3, in a preferred embodiment, the drug-loaded microsphere preparation apparatus 10 further comprises a reflux module 500, the reflux module 500 is used for recovering the organic solvent evaporated in the production process, the reflux module 500 comprises a condensation unit 510 and a purification unit 520, the condensation unit 510 is communicated with the suspension generation module 100 through a pipeline, vapor formed by the suspension generation module 100 enters the condensation unit 510 under the action of pressure, the condensation unit 510 is used for collecting the vapor and condensing the vapor to form liquid mixed liquid, one end of the purification unit 520 is communicated with the condensation unit 510, the mixed liquid flows into the purification unit 520 from the condensation unit 510, and the other end of the purification unit 520 is communicated with the suspension generation module 100, purification unit 520 is used to purify the mixed liquor, purify the organic solvent and deliver the organic solvent to suspension generation module 100.

In the drug-loaded microsphere preparation device 10, vapor evaporated in the production process is condensed and recovered in the condensation unit 510, and then extracted in the purification unit 520 to form an organic solvent, and the organic solvent is conveyed to the suspension generation module 100 for reuse. Therefore, through setting up above-mentioned backward flow module 500 and can retrieve and recycle organic solvent, can avoid the waste of resource on the one hand, save the cost, on the other hand can also avoid steam directly to discharge contaminated air in the air to the environmental protection. In a specific configuration, the condensing unit 510 includes a condensing tube, and the condensing temperature of the organic gas volatilized by the emulsification reaction is different at different saturated vapor pressures, so that the gas is condensed and recovered by cooling the condensing tube with a condensate, which may be cold water or frozen brine at 0-4 ℃. The purification unit 520 includes a rectification device capable of realizing multi-stage distillation, and under a certain pressure, the concentration of light components in the gas phase and heavy components in the liquid phase is gradually increased through multiple partial liquid phase gasification and gas phase condensation due to different boiling points of the mixed components, so as to realize separation. Of course, the reflow module 500 is not limited to the above-mentioned structural forms of the condensation unit 510 and the purification unit 520, and may further include one or more of a first receiving unit 530, a second receiving unit 540, an adding unit 550, and an extracting unit 560, the first receiving unit 530 is disposed between the purification unit 520 and the condensation unit 510 and communicates the purification unit 520 and the condensation unit 510 for storing the mixed liquid, the second receiving unit 540 is disposed between the purification unit 520 and the suspension generation module 100 and communicates the purification unit 520 and the oil phase proportioning unit 130 for storing the organic solvent, the adding unit 550 is connected to the second receiving unit 540 for adding the organic solvent, and the extracting unit 560 is disposed between the second receiving unit 540 and the oil phase proportioning unit 130 for extracting the organic solvent from the second receiving unit 540 into the oil phase proportioning unit 130.

The drug-loaded microsphere preparation device 10 is described below with reference to a comparative example and a preparation example.

Comparative example: 10g of rapamycin and 2g of polymer are placed in a preparation container, 1L of dichloromethane is placed in another preparation container, mixing parameters are set, the proportion of organic solvent medicine containing medicine and polymer is 10ml and is 120mg and 24mg, and the mixture is stirred to be fully and uniformly mixed to serve as an oil phase for standby. Putting the water phase raw material into a raw material loading container, uniformly stirring and mixing 100L of distilled water and Tween 805L, uniformly mixing the water phase raw material with the oil phase, carrying out primary reaction, controlling the speed of an oil phase titration speed control unit to be 8ml/min by 150, emulsifying for 10min at the rotating speed of 4000, volatilizing the solvent at the rotating speed of 200rmp by a stirrer 120, curing microspheres for 5h, fully reacting the solution, completely emulsifying, and directly carrying out centrifugal drying. The dried sample was subjected to scanning electron microscopy to obtain the result shown in FIG. 8. In the method, the particle size is not limited by the screening module 200, that is, the microspheres solidified into spheres after emulsification are directly separated and dried, most of the obtained microspheres are homogeneous microspheres, but a few non-uniform microspheres with small particle sizes exist, and for the drug-loaded microspheres 21, the problems in the aspects of drug stability and drug release are solved.

Preparation examples: in the suspension generation module 100, 15g of rapamycin and 5g of polymer are placed in a preparation container, 1.5L of dichloromethane is placed in another preparation container, mixing parameters are set, the proportion of organic solvent drugs containing drugs and polymers is 10ml and is 100mg and 150mg, and the mixture is stirred to be fully and uniformly mixed to serve as an oil phase for later use. Putting water phase raw materials into a raw material loading container, uniformly stirring and mixing 100L of distilled water and tween 804L, uniformly mixing the raw materials with an oil phase for one-time reaction, controlling the speed of an oil phase titration speed control unit to be 8ml/min by 150, emulsifying the mixture for 10min at the rotation speed of 4000 by a stirrer 120, volatilizing a solvent at the rotation speed of 200rmp, solidifying microspheres for 5 hours, fully reacting and emulsifying the solution to form a suspension 20, separating the suspension by a screening module 200, limiting a first set value to be 10um and a second set value to be 3um, ensuring that the particle size of the drug-loaded microspheres 21 to be obtained is between 3um and 10um, inputting the suspension 20 from one end of a spraying unit 220, reversely spraying the suspension 20 from the other end along a lower cavity 213 towards an upper cavity 212 towards a primary filtering unit 230, carrying out first separation on the primary filtering unit 230 and separating the suspension 20 into two parts, and ensuring that the microspheres with the particle size larger than 10um cannot pass through and fall back to a baffle 211, the first filtering liquid 24 with the particle size not larger than 10um is remained in the first-stage filtering unit 230 and is guided to the lower chamber 213 through the first-stage filtering unit 230, the first filtering liquid 24 is sprayed towards the second-stage filtering unit 240 from a liquid outlet, and is separated for the second time at the second-stage filtering unit 240, the drug-loaded microspheres 21 with the particle size not smaller than 3um cannot pass through and remain above the second-stage filtering unit 240, so that the drug-loaded microspheres 21 are screened, the particle size of the drug-loaded microspheres 21 is between 3um and 10um at the moment, the drug-loaded microspheres 21 after being separated and dried are scanned by a scanning electron microscope as shown in figure 9, the drug-loaded microspheres 21 passing through the drug-loaded microsphere preparation device 10 are uniform in particle size, the drug-loaded amount is relatively uniform, the microspheres in the suspension 20 are divided into three size ranges, and the required specification of automatic screening is realized.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (10)

1. The utility model provides a medicine carrying microsphere preparation facilities, its characterized in that generates module and screening module including the suspension, the screening module includes cavity, spraying unit, one-level filter unit, second grade filter unit, wherein:

the baffle is arranged in the cavity and divides the cavity into an upper cavity and a lower cavity which are sequentially arranged from top to bottom;

one end of the spraying unit is communicated with the suspension generation module, the other end of the spraying unit extends into the upper chamber, and the suspension is sprayed along the direction of the lower chamber towards the upper chamber;

the primary filtering unit is arranged on one side, away from the lower chamber, of the spraying unit in the upper chamber, is communicated with the lower chamber in a diversion way and is used for separating a first filtering liquid with the particle size not larger than a first set value;

the secondary filtering unit is arranged in the lower cavity, is positioned at one side of the baffle plate away from the liquid outlet of the first filtering liquid and is used for separating drug-loaded microspheres with the particle size not less than a second set value.

2. The drug-loaded microsphere preparation device of claim 1, wherein the primary filtering unit comprises a first container and a first microporous filtering membrane, the first container is fixed on the inner wall of the upper chamber, an opening is formed in one side of the first container facing the spraying unit, the first microporous filtering membrane is fixed on one side of the first container facing the spraying unit, and the pore diameter is the first set value.

3. The drug-loaded microsphere preparation device of claim 2, wherein the first container is communicated with the lower chamber in a diversion way through a pumping unit, the pumping unit is provided with a first diversion pipe, one end of the first diversion pipe extends into the upper chamber and is communicated with the first container, the other end of the first diversion pipe extends into the lower chamber, and the first diversion pipe is positioned on one side of the second-stage filtering unit close to the baffle.

4. The drug-loaded microsphere preparation device according to claim 2, wherein the secondary filtration unit comprises a second container and a second microfiltration membrane, the second container is arranged on the inner wall of the lower chamber and has a microcavity penetrating through the thickness of the second container, the aperture of the microcavity is not smaller than the second set value, and the second microfiltration membrane is detachably mounted on one side of the second container facing the baffle and has the second set value.

5. The device for preparing drug-loaded microspheres according to claim 4, wherein the second container is rotatably disposed on the inner wall of the lower chamber, a partition plate is protruded from one side of the second container facing the baffle plate, the partition plate extends to a position below the liquid outlet of the first filtrate, and divides the space between the baffle plate and the second container into at least two accommodating cavities, the liquid outlet of the first filtrate is located in the accommodating cavities, and the second microporous filtration membrane is clamped on part of the second container in each accommodating cavity.

6. The drug-loaded microsphere preparation device according to claim 4, wherein the sieving module further comprises a third microfiltration membrane, the third microfiltration membrane is arranged in the upper chamber and is located on one side of the spraying unit far away from the primary filtering unit, and the third microfiltration membrane has the same filtering pore size as the first microfiltration membrane and is used for separating the first filtrate.

7. The drug-loaded microsphere preparation device of claim 6, wherein the sieving module further comprises a fourth microfiltration membrane, the fourth microfiltration membrane is arranged in the upper chamber and is located at one side of the third microfiltration membrane away from the spraying unit, and the fourth microfiltration membrane has the same filtering aperture as the second microfiltration membrane and is used for separating the drug-loaded microspheres.

8. The drug-loaded microsphere preparation device of claim 6, further comprising a second flow guide pipe, wherein one end of the second flow guide pipe extends into the upper chamber and is arranged on the baffle, and the other end of the second flow guide pipe extends into the lower chamber and is positioned on one side of the second-stage filtering unit close to the baffle.

9. The drug-loaded microsphere preparation device of claim 1, further comprising a first collection unit and a second collection unit, wherein one end of the first collection unit extends into the upper chamber and is arranged on the baffle plate, and one end of the second collection unit is inserted into the through groove on the bottom wall of the lower chamber.

10. The drug-loaded microsphere preparation device according to claim 1, further comprising a reflux module, wherein the reflux module comprises a condensation unit and a purification unit, the condensation unit is communicated with the suspension generation module and used for collecting and condensing steam, one end of the purification unit is communicated with the condensation unit, and the other end of the purification unit is communicated with the suspension generation module and used for purifying and conveying an organic solvent.

Images