CN112870427A - Hydrogel elastic patch and preparation method thereof - Google Patents
Hydrogel elastic patch and preparation method thereof Download PDFInfo
- Publication number
- CN112870427A CN112870427A CN202110271604.XA CN202110271604A CN112870427A CN 112870427 A CN112870427 A CN 112870427A CN 202110271604 A CN202110271604 A CN 202110271604A CN 112870427 A CN112870427 A CN 112870427A
- Authority
- CN
- China
- Prior art keywords
- hydrogel
- elastic
- elastic material
- percent
- material layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000017 hydrogel Substances 0.000 title claims abstract description 89
- 238000002360 preparation method Methods 0.000 title abstract description 16
- 239000013013 elastic material Substances 0.000 claims abstract description 58
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 35
- 229920000642 polymer Polymers 0.000 claims abstract description 31
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 23
- 239000000463 material Substances 0.000 claims abstract description 9
- 239000003814 drug Substances 0.000 claims abstract description 6
- 238000013329 compounding Methods 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims description 29
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 18
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical group O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 16
- 238000004132 cross linking Methods 0.000 claims description 16
- 239000003112 inhibitor Substances 0.000 claims description 16
- 239000002904 solvent Substances 0.000 claims description 16
- 239000008367 deionised water Substances 0.000 claims description 15
- 229910021641 deionized water Inorganic materials 0.000 claims description 15
- 239000011259 mixed solution Substances 0.000 claims description 15
- 238000001035 drying Methods 0.000 claims description 14
- 239000003607 modifier Substances 0.000 claims description 14
- 239000003431 cross linking reagent Substances 0.000 claims description 13
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 230000003750 conditioning effect Effects 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 12
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 12
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 12
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 12
- 239000003755 preservative agent Substances 0.000 claims description 12
- 238000010521 absorption reaction Methods 0.000 claims description 11
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 11
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 11
- 230000001804 emulsifying effect Effects 0.000 claims description 10
- 150000002500 ions Chemical class 0.000 claims description 10
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 9
- 239000004480 active ingredient Substances 0.000 claims description 9
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 9
- 230000002335 preservative effect Effects 0.000 claims description 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 8
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 8
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 8
- 239000011248 coating agent Substances 0.000 claims description 8
- 238000000576 coating method Methods 0.000 claims description 8
- 239000003623 enhancer Substances 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 8
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 8
- 229920000053 polysorbate 80 Polymers 0.000 claims description 8
- 239000011975 tartaric acid Substances 0.000 claims description 8
- 235000002906 tartaric acid Nutrition 0.000 claims description 8
- 239000004408 titanium dioxide Substances 0.000 claims description 8
- 239000002131 composite material Substances 0.000 claims description 7
- 229920001577 copolymer Polymers 0.000 claims description 7
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 7
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 7
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 6
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 6
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 6
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 5
- 239000005995 Aluminium silicate Substances 0.000 claims description 5
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical group OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 5
- 229920002125 Sokalan® Polymers 0.000 claims description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical group [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 5
- 229910052782 aluminium Inorganic materials 0.000 claims description 5
- 235000012211 aluminium silicate Nutrition 0.000 claims description 5
- 238000001723 curing Methods 0.000 claims description 5
- 238000004043 dyeing Methods 0.000 claims description 5
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 5
- 229920002521 macromolecule Polymers 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 5
- 229960005323 phenoxyethanol Drugs 0.000 claims description 5
- 239000000419 plant extract Substances 0.000 claims description 5
- 239000011347 resin Substances 0.000 claims description 5
- 229920005989 resin Polymers 0.000 claims description 5
- 238000010008 shearing Methods 0.000 claims description 5
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 4
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 4
- 238000004945 emulsification Methods 0.000 claims description 4
- 239000000284 extract Substances 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- 230000035515 penetration Effects 0.000 claims description 4
- 239000004584 polyacrylic acid Substances 0.000 claims description 4
- 239000002952 polymeric resin Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 229960003415 propylparaben Drugs 0.000 claims description 4
- 229920003002 synthetic resin Polymers 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 3
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 3
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 3
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 3
- 229960002216 methylparaben Drugs 0.000 claims description 3
- 239000003961 penetration enhancing agent Substances 0.000 claims description 3
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 3
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 3
- 238000013268 sustained release Methods 0.000 claims description 3
- 239000012730 sustained-release form Substances 0.000 claims description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 2
- 125000005907 alkyl ester group Chemical group 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 229920002313 fluoropolymer Polymers 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 239000002480 mineral oil Substances 0.000 claims description 2
- 235000010446 mineral oil Nutrition 0.000 claims description 2
- 230000036961 partial effect Effects 0.000 claims description 2
- 235000013772 propylene glycol Nutrition 0.000 claims description 2
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 2
- 229920002725 thermoplastic elastomer Polymers 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- -1 poly (fluoroalkyl acrylate Chemical compound 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 239000004744 fabric Substances 0.000 abstract description 34
- 239000000084 colloidal system Substances 0.000 abstract description 6
- 210000004243 sweat Anatomy 0.000 abstract description 5
- 230000008901 benefit Effects 0.000 abstract description 4
- 230000035699 permeability Effects 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 3
- 229920001477 hydrophilic polymer Polymers 0.000 abstract 1
- 230000000717 retained effect Effects 0.000 abstract 1
- 231100000245 skin permeability Toxicity 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 11
- 239000000047 product Substances 0.000 description 9
- 239000000203 mixture Substances 0.000 description 6
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 5
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 5
- 229940041616 menthol Drugs 0.000 description 5
- 238000010998 test method Methods 0.000 description 5
- DATAGRPVKZEWHA-YFKPBYRVSA-N N(5)-ethyl-L-glutamine Chemical compound CCNC(=O)CC[C@H]([NH3+])C([O-])=O DATAGRPVKZEWHA-YFKPBYRVSA-N 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 239000012466 permeate Substances 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 230000035900 sweating Effects 0.000 description 3
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- 241000628997 Flos Species 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
- 244000062730 Melissa officinalis Species 0.000 description 2
- 235000010654 Melissa officinalis Nutrition 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 235000020221 chamomile extract Nutrition 0.000 description 2
- 229940119217 chamomile extract Drugs 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 229960004194 lidocaine Drugs 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- LDCYZAJDBXYCGN-VIFPVBQESA-N 5-hydroxy-L-tryptophan Chemical compound C1=C(O)C=C2C(C[C@H](N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-VIFPVBQESA-N 0.000 description 1
- 229940000681 5-hydroxytryptophan Drugs 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 244000061520 Angelica archangelica Species 0.000 description 1
- 241000213006 Angelica dahurica Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000717739 Boswellia sacra Species 0.000 description 1
- QUVCFQAHXXKABX-UHFFFAOYSA-K C(CO)(=O)[O-].O[Al+]O Chemical compound C(CO)(=O)[O-].O[Al+]O QUVCFQAHXXKABX-UHFFFAOYSA-K 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
- 240000004530 Echinacea purpurea Species 0.000 description 1
- 239000004863 Frankincense Substances 0.000 description 1
- 239000006000 Garlic extract Substances 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
- 239000004831 Hot glue Substances 0.000 description 1
- 241000721662 Juniperus Species 0.000 description 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- DATAGRPVKZEWHA-UHFFFAOYSA-N L-gamma-glutamyl-n-ethylamine Natural products CCNC(=O)CCC(N)C(O)=O DATAGRPVKZEWHA-UHFFFAOYSA-N 0.000 description 1
- 206010050031 Muscle strain Diseases 0.000 description 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
- 235000005805 Prunus cerasus Nutrition 0.000 description 1
- 244000207449 Prunus puddum Species 0.000 description 1
- 235000009226 Prunus puddum Nutrition 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 229960003121 arginine Drugs 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 230000035587 bioadhesion Effects 0.000 description 1
- QRZAKQDHEVVFRX-UHFFFAOYSA-N biphenyl-4-ylacetic acid Chemical compound C1=CC(CC(=O)O)=CC=C1C1=CC=CC=C1 QRZAKQDHEVVFRX-UHFFFAOYSA-N 0.000 description 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
- 229940116229 borneol Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229940007061 capsicum extract Drugs 0.000 description 1
- 239000001943 capsicum frutescens fruit extract Substances 0.000 description 1
- 239000010630 cinnamon oil Substances 0.000 description 1
- 229960004544 cortisone Drugs 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
- 235000014134 echinacea Nutrition 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000005489 elastic deformation Effects 0.000 description 1
- 210000002310 elbow joint Anatomy 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 229960000192 felbinac Drugs 0.000 description 1
- 235000020706 garlic extract Nutrition 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 229960002449 glycine Drugs 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 229960004752 ketorolac Drugs 0.000 description 1
- OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 description 1
- 235000020723 lavender extract Nutrition 0.000 description 1
- 229940083980 lavender extract Drugs 0.000 description 1
- 229960004393 lidocaine hydrochloride Drugs 0.000 description 1
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 229960002373 loxoprofen Drugs 0.000 description 1
- BAZQYVYVKYOAGO-UHFFFAOYSA-M loxoprofen sodium hydrate Chemical compound O.O.[Na+].C1=CC(C(C([O-])=O)C)=CC=C1CC1C(=O)CCC1 BAZQYVYVKYOAGO-UHFFFAOYSA-M 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- DJGAAPFSPWAYTJ-UHFFFAOYSA-M metamizole sodium Chemical compound [Na+].O=C1C(N(CS([O-])(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 DJGAAPFSPWAYTJ-UHFFFAOYSA-M 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- LDCYZAJDBXYCGN-UHFFFAOYSA-N oxitriptan Natural products C1=C(O)C=C2C(CC(N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-UHFFFAOYSA-N 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 235000020689 passion flower extract Nutrition 0.000 description 1
- 229940001884 passion flower extract Drugs 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
- 239000001738 pogostemon cablin oil Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 229960001153 serine Drugs 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229940105022 spearmint extract Drugs 0.000 description 1
- 229940026510 theanine Drugs 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
- 235000020767 valerian extract Nutrition 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
- A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a hydrogel elastic patch and a preparation method thereof, wherein the elastic patch comprises an elastic material layer, a high polymer hydrogel layer with a slow release function and a release covering layer which are sequentially arranged; the elastic material layer is an elastic material layer compounded with a hydrophobic auxiliary agent, or a material layer formed by compounding an elastic material and a waterproof material, or an elastic material layer with an air layer structure. According to the invention, through carrying out hydrophobic treatment on the elastic material layer or compounding the elastic material with a waterproof material or the elastic material layer with an air layer structure, the risk that the elastic cloth is combined with hydrogel and is easy to penetrate is solved, and the advantage of good air permeability of the elastic cloth is retained. The hydrophilic polymer hydrogel has good skin-friendly property and skin permeability, long drug release time, good biological adhesiveness with skin, repeated uncovering and pasting, no residual colloid, and good adhesiveness even if a user sweats.
Description
Technical Field
The invention relates to the technical field of medicines and medical instruments, in particular to a hydrogel elastic patch and a preparation method thereof.
Background
Because people pay more and more attention to health, frequent sports, muscle strain is inevitable, or muscle needs to be protected before sports, but the traditional products on the market are easy to fall off due to sweating in the process of sports, or are used in combination with protective equipment, so that the use sense is heavy.
Current bandage development is largely around base fabric improvements, including the use of self-adhesive tape, stretch base fabrics, and the like. However, after treatment of a wound, direct contact between the bandage and the skin wound, often with exudates around the wound, and often poor breathability of the bandage, bacterial infection is likely to occur. Brings great pain to the wound and is not beneficial to the healing of the wound. The existing bandage using the hot melt adhesive coating cannot have a substantial transdermal drug delivery function, the colloid layout has salt resistance, or some hydrogel bandage products have a complicated structure due to the defect that hydrogel is easy to penetrate through cloth, the use feeling is heavy, the skin-sticking feeling is poor, the product is not light and thin, and the product is easy to fall off after sweating during sports.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a hydrogel elastic patch and a preparation method thereof.
The purpose of the invention is realized by the following technical scheme:
the invention provides a hydrogel elastic patch, which comprises an elastic material layer, a high polymer hydrogel layer with a slow release function and a release covering layer which are sequentially arranged;
the elastic material layer is compounded with hydrophobic auxiliary agent, or the elastic material layer is compounded with waterproof material, or the elastic material layer is provided with an air layer structure.
Preferably, the polymer hydrogel with the slow release function comprises the following components in percentage by mass:
0.01 to 15 percent of active medicine component, 0.01 to 15 percent of ion inhibitor, 0.01 to 1 percent of cross-linking agent, 0.1 to 10 percent of macromolecular resin, 10 to 35 percent of solvent, 0.1 to 15 percent of skin feel conditioning agent, 10 to 50 percent of deionized water, 0.1 to 3 percent of appearance conditioning agent, 0.01 to 1 percent of cross-linking conditioning agent, 0.01 to 1 percent of preservative and 0.01 to 5 percent of transdermal absorption penetration enhancer.
Preferably, the polymer hydrogel comprises the following components in percentage by mass:
1 to 10 percent of active ingredients, 3 to 10 percent of ion inhibitors, 0.1 to 0.5 percent of cross-linking agents, 5 to 10 percent of macromolecular resins, 20 to 35 percent of solvents, 1 to 5 percent of skin feel conditioning agents, 30 to 55 percent of deionized water, 0.1 to 1 percent of appearance conditioning agents, 0.1 to 1 percent of cross-linking conditioning agents, 0.1 to 0.5 percent of preservatives and 1 to 5 percent of transdermal absorption penetration enhancers.
More preferably, the polymer hydrogel comprises the following components in percentage by mass:
4 to 6 percent of active ingredients, 5 percent of ion inhibitors, 0.1 to 0.2 percent of cross-linking agents, 8 to 9.5 percent of macromolecular resins, 30 to 33 percent of solvents, 0.1 percent of skin feel conditioning agents, 40.9 to 52.04 percent of deionized water, 0.05 to 0.1 percent of appearance conditioning agents, 0.2 percent of cross-linking conditioning agents, 0.1 percent of preservatives and 0.5 percent of transdermal absorption penetration enhancers.
Preferably, the active ingredients comprise any one or more of medicinal ingredients, traditional Chinese medicine powder or extract, amino acids and plant extracts; for example, the pharmaceutical composition can be selected from analgesic components such as glucosamine, capsicum extract, camphor, menthol, methyl salicylate, lidocaine hydrochloride, etc., and can also be selected from anti-inflammatory analgesic components such as aspirin, analgin, acetaminophen, indomethacin, piroxicam, ketorolac, cortisone, hydrocortisone, dexamethasone, glycyrrhetinic acid, felbinac, loxoprofen, etc.; the Chinese medicinal powder or extractive solution can be selected from Borneolum Syntheticum, Aloe, flos Camelliae Japonicae, Olibanum resin, flos Caraganae Sinicae, radix Angelicae sinensis, semen Cassiae, herba Sidae Rhombifoliae, purple coneflower, and juniper fruit; the amino acid can be selected from glycine, serine, L-tryptophan, arginine, ornithine, 5-hydroxytryptophan, L-theanine, and theanine; the plant extract can be selected from plant extracts of sleep-aiding components such as valerian extract, passion flower extract, lemon balm leaf, chamomile extract, lavender extract, chamomile extract, balm extract, sour cherry extract, garlic extract, spearmint extract and the like, and can also be selected from plant extracts with the functions of refreshing and restoring consciousness such as wintergreen oil, angelica dahurica oil, angelica oil, cinnamon oil, eucalyptus oil, peppermint oil, borneol, patchouli oil and the like;
the ionic inhibitor comprises at least one of polyvinylpyrrolidone and a nonionic ionic inhibitor of polyvinyl alcohol;
the cross-linking agent is aluminum glycollate or aluminum hydroxide.
Preferably, the polymer resin is at least one of polyacrylic acid and sodium polyacrylate;
the solvent comprises at least one of glycerol, propylene glycol, mineral oil and polyoxyethylene sorbitan monooleate;
the skin feeling regulator is at least one of kaolin and sodium carboxymethyl cellulose;
the appearance regulator is titanium dioxide.
More preferably, the skin feel modifier is kaolin, which is an oil-absorbing inorganic powder that can modify the oil components secreted on the skin during exercise.
Preferably, the crosslinking regulator is at least one of tartaric acid, citric acid, EDTA-2Na, EDTA-4Na, malic acid and lactic acid;
the preservative is at least one of benzalkonium chloride, methyl paraben, propyl paraben and phenoxyethanol;
the transdermal absorption penetration enhancer is at least one of isopropyl myristate, dimethyl sulfoxide and azone.
Preferably, the preparation method of the polymer hydrogel with the slow release function comprises the following steps:
s1, mixing the sodium polyacrylate, the cross-linking agent, the cross-linking regulator and the appearance regulator with part of the solvent, stirring for 8-15 minutes at normal temperature, and uniformly dispersing to form phase A;
s2, adding the active pharmaceutical ingredients into partial solvent to be dissolved completely into a B phase at normal temperature;
s3, stirring the ionic inhibitor, the skin feel regulator, the transdermal absorption enhancer and the preservative for 15-20 minutes at normal temperature to form a mixed solution which is a phase C;
and S4, emulsifying the phase B and the phase C in a homogenizing emulsifying machine, pouring the emulsified liquid into a vacuum stirring kettle, mixing the phase A into the vacuum stirring kettle, and stirring to obtain the polymer hydrogel with the slow release function.
Preferably, in step S4, the rotation speed of emulsification is 4000r/min, and the emulsification time is 10-15 minutes; the stirring speed is 40-60r/min, and the stirring time is 10-15 minutes.
The hydrophobic auxiliary agent is at least one selected from a polyacrylic fluoroalkyl ester copolymer, organic silicon, a fluorocarbon polymer, a long-chain alkyl ester and a copolymer thereof.
Preferably, the preparation method of the composite hydrophobic auxiliary agent on the elastic material layer is as follows:
mixing the hydrophobic auxiliary agent and water according to the proportion of 6:94-12:88 to obtain a mixed solution, dyeing and fixing the elastic material, immersing the elastic material in the mixed solution for 5 minutes after finishing, pre-drying the elastic material for 2 minutes at the temperature of 120-140 ℃, and then sequentially drying the elastic material for 1 minute at the temperature of 150-155 ℃, 2 minutes at the temperature of 160-165 ℃ and 5 minutes at the temperature of 180-190 ℃ to obtain the elastic material layer of the composite hydrophobic auxiliary agent.
Preferably, the release covering layer comprises covering layers made of various materials and having a release effect, and is specifically selected from any one of silicone oil paper, a pearlized film, a PP release film and a PET release film.
The invention also provides a preparation method of the hydrogel elastic patch, which comprises the following steps: coating a macromolecule hydrogel layer with a slow release function on the elastic material layer, then covering a release covering layer, shearing, curing and packaging to obtain the product.
Compared with the prior art, the invention has the following beneficial effects:
1. the hydrogel elastic patch prepared by the invention is suitable for use during sports and is not easy to fall off; and the adopted elastic material has good air permeability and elastic deformation force effect, is particularly suitable for elbow joints and can be well pasted.
2. The existing elastic cloth is easy to pull due to large elasticity and has larger gaps, and the colloid is easy to flow out from the gaps of the elastic cloth due to fluidity when hydrogel is coated; the invention solves the risk of easy cloth penetration of the combination of the elastic cloth and the hydrogel by performing hydrophobic treatment on the elastic material layer or compounding the elastic material with the TPU, and simultaneously reserves the advantage of good air permeability of the elastic cloth.
3. The hydrogel layer adopted by the invention is formed by the way that sodium polyacrylate exists in a hydrophilic matrix in a cross-linked state, the formed polymer skeleton embeds active ingredients, and the colloid is compounded with a nonionic water-based ion inhibitor to improve the salt resistance of the colloid.
Drawings
Other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments with reference to the following drawings:
fig. 1 is a structural diagram of a hydrogel elastic patch, wherein, 1 is a release covering layer, 2 is a macromolecule hydrogel layer with a slow release function, and 3 is an elastic material layer.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications can be made by persons skilled in the art without departing from the spirit of the invention. All falling within the scope of the present invention.
Example 1
The embodiment provides a hydrogel elastic patch, as shown in fig. 1, which includes a release cover layer 1, a polymer hydrogel layer 2 with a slow release function, and an elastic material layer 3, which are sequentially disposed. The elastic material layer 3 is elastic cloth compounded with hydrophobic additives, and the release covering layer 1 is a pearlized film.
The polymer hydrogel layer with the slow release function comprises the following components in percentage by mass: 4% lidocaine (active pharmaceutical ingredient), 5% polyvinylpyrrolidone (ion inhibitor), 0.1% aluminum glycollate (cross-linking agent), 5% sodium polyacrylate (polymer resin), polyacrylic acid 3% (polymer resin), 24% glycerol (solvent), 5% propylene glycol (solvent), 1% polyoxyethylene sorbitan monooleate (solvent), 0.1% kaolin (skin feel modifier), 0.05% titanium dioxide (appearance modifier), 0.1% tartaric acid (cross-linking modifier), 0.1% EDTA-2Na (cross-linking modifier), 0.1% phenoxyethanol (preservative), 0.5% dimethyl sulfoxide (transdermal absorption enhancer), 51.95% deionized water.
The preparation method of the elastic cloth compounded with the hydrophobic auxiliary agent comprises the following steps: mixing a polyfluoroalkyl acrylate copolymer (a hydrophobic auxiliary agent) with water according to the proportion of 6:94 to form a mixed solution, dyeing and fixing the elastic material, immersing the elastic material into the mixed solution for 5 minutes after finishing, then pre-drying the elastic material for 2 minutes at the temperature of 120-155 ℃, then drying the elastic material for 1 minute at the temperature of 150-155 ℃, drying the elastic material for 2 minutes at the temperature of 160-165 ℃ and drying the elastic material for 5 minutes at the temperature of 180-190 ℃ in sequence to obtain the modified polyfluoroalkyl acrylate. The hydrophobic grade of the elastic cloth can reach more than 5 grade according to the test method in AATCC-127-.
The preparation method of the hydrogel elastic patch in this example is as follows:
(1) stirring sodium polyacrylate, dihydroxyaluminum glycolate, kaolin, EDTA-2Na, tartaric acid and glycerol at normal temperature for 10 minutes to obtain phase A;
(2) adding lidocaine into propylene glycol and polyoxyethylene sorbitan monooleate, and dissolving at normal temperature to obtain phase B;
(3) and stirring polyvinylpyrrolidone, titanium dioxide, dimethyl sulfoxide and phenoxyethanol in deionized water at normal temperature for 15-20 minutes to form a mixed solution which is a phase C.
(4) And emulsifying the phase B and the phase C in a homogenizing emulsifying machine for 10-15 minutes at the rotation speed of 4000r/min, pouring the mixed liquid into a vacuum stirring kettle, mixing the phase A with the mixed liquid, and stirring for 10-15 minutes at the stirring speed of 40-60r/min to form the polymer hydrogel with the slow release function.
(5) Coating the elastic cloth compounded with the hydrophobic auxiliary agent with polymer hydrogel with a slow release function, then covering the elastic cloth with a pearlized film, shearing, curing and packaging to obtain the water-based coating.
The hydrogel elastic patch prepared by the invention does not permeate hydrogel on the elastic cloth due to the hydrophobic treatment of the elastic cloth.
Example 2
The embodiment provides a hydrogel elastic patch, as shown in fig. 1, which includes a release cover layer 1, a polymer hydrogel layer 2 with a slow release function, and an elastic material layer 3, which are sequentially disposed. The elastic material layer 3 is elastic cloth compounded with hydrophobic additives, and the release covering layer 1 is a pearlized film.
The polymer hydrogel layer with the slow release function comprises the following components in percentage by mass: 5% menthol (active ingredient), 5% polyvinylpyrrolidone (ion inhibitor), 0.1% aluminum glycollate (cross-linking agent), 5.5% sodium polyacrylate (polymer), 3.5% polyacrylic acid (polymer), 23% glycerol (solvent), 7% propylene glycol (solvent), 1% polyoxyethylene sorbitan monooleate (solvent), 0.1% sodium carboxymethylcellulose (skin feel modifier), 0.1% titanium dioxide (appearance modifier), 0.1% tartaric acid (cross-linking modifier), 0.1% EDTA-2Na (cross-linking modifier), 0.1% benzalkonium chloride (preservative), 0.5% isopropyl myristate (transdermal absorption enhancer), 48.9% deionized water.
The preparation method of the elastic cloth compounded with the hydrophobic auxiliary agent comprises the following steps: mixing a polyfluoroalkyl acrylate copolymer (a hydrophobic auxiliary agent) with water according to the proportion of 8:92 to form a mixed solution, dyeing and fixing the elastic material, immersing the elastic material into the mixed solution for 5 minutes after finishing, then pre-drying the elastic material for 2 minutes at the temperature of 120-155 ℃, then drying the elastic material for 1 minute at the temperature of 150-155 ℃, drying the elastic material for 2 minutes at the temperature of 160-165 ℃ and drying the elastic material for 5 minutes at the temperature of 180-190 ℃ in sequence to obtain the modified polyfluoroalkyl acrylate. The hydrophobic grade of the elastic cloth can reach more than 5 grade according to the test method in AATCC-127-.
The preparation method of the hydrogel elastic patch in this example is as follows:
(1) stirring sodium polyacrylate, aluminium glycollate, sodium carboxymethylcellulose, EDTA-2Na, tartaric acid and glycerol at normal temperature for 10 min to obtain phase A;
(2) adding menthol into propylene glycol and polyoxyethylene sorbitan monooleate, and dissolving at normal temperature to obtain phase B;
(3) stirring polyvinylpyrrolidone, titanium dioxide, isopropyl myristate and phenoxyethanol in deionized water at normal temperature for 15-20 minutes to form a mixed solution as a C phase.
(4) Emulsifying the phase B and the phase C in a homogenizing emulsifying machine for 10-15 minutes at the rotation speed of 4000r/min, pouring the mixed liquid into a vacuum stirring kettle, mixing the phase A with the mixed liquid, and stirring for 10-15 minutes at the stirring speed of 40-60r/min to form the hydrogel paste embedding the active ingredients.
(5) Coating the elastic cloth compounded with the hydrophobic auxiliary agent with polymer hydrogel with a slow release function, then covering the elastic cloth with a pearlized film, shearing, curing and packaging to obtain the water-based coating.
The hydrogel elastic patch prepared by the invention does not permeate hydrogel on the elastic cloth due to the hydrophobic treatment of the elastic cloth.
Example 3
The embodiment provides a hydrogel elastic patch, as shown in fig. 1, which includes a release cover layer 1, a polymer hydrogel layer 2 with a slow release function, and an elastic material layer 3, which are sequentially disposed. The elastic material layer 3 is elastic cloth compounded with hydrophobic auxiliary agents, and the release covering layer 1 is a pp release film.
The polymer hydrogel layer with the slow release function comprises the following components in percentage by mass: 5% menthol (active pharmaceutical ingredient), 5% polyvinylpyrrolidone (ion inhibitor), 0.2% aluminium hydroxide (cross-linking agent), 3.5% sodium polyacrylate (macromolecule), 6% polyacrylic acid (macromolecule), 25% glycerol (solvent), 7% propylene glycol (solvent), 1% polyoxyethylene sorbitan monooleate (solvent), 0.1% sodium carboxymethylcellulose (skin feel modifier), 0.1% titanium dioxide (appearance modifier), 0.1% tartaric acid (cross-linking modifier), 0.1% EDTA-2Na (cross-linking modifier), 0.1% methyl paraben (preservative), 0.1% propyl paraben (preservative), 0.5% isopropyl myristate (transdermal absorption enhancer), 46.2% deionized water.
The preparation method of the elastic cloth compounded with the hydrophobic auxiliary agent comprises the following steps: mixing a polyfluoroalkyl acrylate copolymer (a hydrophobic auxiliary agent) with water according to a ratio of 9:91 to form a mixed solution, dyeing and fixing the elastic material, immersing the elastic material into the mixed solution for 5 minutes after finishing, then pre-drying the elastic material at the temperature of 120-155 ℃ for 2 minutes, and then sequentially drying the elastic material at the temperature of 150-155 ℃ for 1 minute, at the temperature of 160-165 ℃ for 2 minutes, and at the temperature of 180-190 ℃ for 5 minutes to obtain the modified polyfluoroalkyl acrylate/hydrophobic auxiliary agent. The hydrophobic grade of the elastic cloth can reach more than 5 grade according to the test method in AATCC-127-.
The preparation method of the hydrogel elastic patch comprises the following steps:
(1) stirring sodium polyacrylate, aluminum hydroxide, sodium carboxymethylcellulose, EDTA-2Na, tartaric acid and glycerol at normal temperature for 10 minutes to obtain phase A;
(2) adding menthol into propylene glycol and polyoxyethylene sorbitan monooleate, and dissolving at normal temperature to obtain phase B;
(3) and stirring polyvinylpyrrolidone, titanium dioxide, isopropyl myristate, methyl hydroxybenzoate and propyl hydroxybenzoate in deionized water at normal temperature for 15-20 min to obtain a mixed solution as phase C.
(4) Emulsifying the phase B and the phase C in a homogenizing emulsifying machine for 10-15 minutes at the rotation speed of 4000r/min, pouring the mixed liquid into a vacuum stirring kettle, mixing the phase A with the mixed liquid, and stirring for 10-15 minutes at the stirring speed of 40-60r/min to form the hydrogel paste embedding the active ingredients.
(5) And (3) coating the macromolecular hydrogel with the slow release function on the elastic cloth of the composite hydrophobic auxiliary agent, then covering a pp release film, shearing, curing and packaging to obtain the composite hydrophobic auxiliary agent.
The hydrogel elastic patch prepared by the invention does not permeate hydrogel on the elastic cloth due to the hydrophobic treatment of the elastic cloth.
Example 4
The invention provides a hydrogel elastic patch which is basically the same as the structure of the embodiment 1, and is different from the embodiment in that: in the composition of each component of the polymer hydrogel with the sustained-release function, polyvinyl alcohol is used to replace polyvinylpyrrolidone in this example.
The hydrogels prepared in examples 1-4 above have good skin-friendly and skin-permeable properties, long drug release time, good bio-adhesion to skin, repeated release, no residual gel, and good adhesion even if a user sweats, especially when used during exercise.
Example 5
The invention provides a hydrogel elastic patch which is basically the same as the structure of the embodiment 1, and is different from the embodiment in that: in the composition of each component of the polymer hydrogel with the slow release function, polyvinyl alcohol is used to replace polyvinylpyrrolidone in this embodiment, and the content of polyvinyl alcohol is 3%, and the content of deionized water is 53.95%.
Example 6
The invention provides a hydrogel elastic patch which is basically the same as the structure of the embodiment 1, and is different from the embodiment in that: in the composition of each component of the polymer hydrogel with the slow release function, polyvinyl alcohol is used to replace polyvinylpyrrolidone in this embodiment, and the content of polyvinyl alcohol is 8%, and the content of deionized water is 48.95%.
Example 7
The invention provides a hydrogel elastic patch which is basically the same as the structure of the embodiment 1, and is different from the embodiment in that: in the components of the polymer hydrogel with the slow release function, polyvinyl alcohol is used to replace polyvinylpyrrolidone in this embodiment, and the content of polyvinyl alcohol is 10%, and the content of deionized water is 46.95%.
Comparative example 1
This comparative example provides a hydrogel elastic patch having substantially the same structural composition as example 1, except that: the polymer hydrogel layer with the slow release function of the comparative example is not added with a cross-linking agent, and the content of deionized water is 52.14%.
The preparation method of the polymer hydrogel is the same as that of example 1.
The gel prepared by the hydrogel elastic patch prepared by the invention has no cross-linking agent, so that the cross-linking process is too fast or too slow, the cross-linking degree of the gel is not uniform, and the gel cannot be coated.
Comparative example 2
This comparative example provides a hydrogel elastic patch having substantially the same structural composition as example 1, except that: the polymer hydrogel layer with the slow release function of the comparative example is not added with an ion inhibitor, and the content of deionized water is 56.95%.
The preparation method of the polymer hydrogel is the same as that of example 1.
The hydrogel elastic patch prepared by the invention is applied for a long time, and is easy to lose stickiness and fall off due to human body sweating.
Comparative example 3
This comparative example provides a hydrogel elastic patch having substantially the same structural composition as example 1, except that: the elastic material layer used in this comparative example was a conventional elastic cloth (i.e., an elastic cloth not compounded with a hydrophobic auxiliary).
The hydrogel elastic patch prepared by the invention has the advantage that hydrogel permeates on the elastic cloth because the elastic cloth is not subjected to hydrophobic treatment.
The hydrogel elastic patches prepared in example 1 and comparative example 2 were cut into 3 pieces of samples with a length of 30cm × 2.5cm, and about 2 g of artificial sweat was uniformly applied to the surface of each piece of hydrogel elastic patch and pretreated at 25 ± 2 ℃ and 60% RH for 2 hours, according to the test method of GB/T2792-:
TABLE 1
From the above test results, comparative example 2 has a significantly reduced adhesion effect under the condition of immersion in artificial sweat, since no ion inhibitor is added.
The hydrogel elastic patches prepared in examples 2-6 were cut into 3 pieces of strip samples of 30cm × 2.5cm according to the aforementioned method, about 2 g of artificial sweat was uniformly coated on the surface of each piece of hydrogel elastic patch and pretreated for 2 hours at 25 ± 2 ℃ and 60% RH according to the test method of GB/T2792-:
TABLE 2
The hydrogel can be coated on a composite waterproof composite material or an air layer material with a certain structure, so that the problem of colloid seepage is solved, the shape of the product is not limited in the attached drawing, the size of the product can be cut at will, the product comprises a product with a hollow-out surface, and the air permeability is improved.
The embodiments described above are described to facilitate an understanding and use of the invention by those skilled in the art. It will be readily apparent to those skilled in the art that various modifications to these embodiments may be made, and the generic principles described herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present invention is not limited to the above embodiments, and those skilled in the art should make improvements and modifications within the scope of the present invention based on the disclosure of the present invention.
Claims (10)
1. The hydrogel elastic patch is characterized by comprising an elastic material layer, a high polymer hydrogel layer with a slow release function and a release covering layer which are sequentially arranged;
the elastic material layer is an elastic material layer compounded with a hydrophobic auxiliary agent, or a material layer formed by compounding an elastic material and a waterproof material, or an elastic material layer with an air layer structure.
2. The hydrogel elastic patch as claimed in claim 1, wherein the polymer hydrogel layer with slow release function comprises the following components by mass percent:
0.01 to 15 percent of active ingredients, 0.01 to 15 percent of ion inhibitors, 0.01 to 1 percent of cross-linking agents, 0.1 to 10 percent of macromolecular resin, 10 to 35 percent of solvents, 0.1 to 15 percent of skin feel conditioning agents, 10 to 50 percent of deionized water, 0.1 to 3 percent of appearance conditioning agents, 0.01 to 1 percent of cross-linking conditioning agents, 0.01 to 1 percent of preservatives and 0.01 to 5 percent of transdermal absorption penetration enhancers.
3. The hydrogel elastic patch as claimed in claim 1, wherein the active ingredient comprises any one or more of a pharmaceutical ingredient, a powder or an extract of a traditional Chinese medicine, an amino acid, and a plant extract;
the ionic inhibitor comprises at least one of polyvinylpyrrolidone and a nonionic ionic inhibitor of polyvinyl alcohol;
the cross-linking agent is aluminum glycollate or aluminum hydroxide.
4. The hydrogel elastic patch as claimed in claim 1, wherein the polymeric resin is at least one of polyacrylic acid and sodium polyacrylate;
the solvent comprises at least one of glycerol, propylene glycol, mineral oil and polyoxyethylene sorbitan monooleate;
the skin feeling regulator is at least one of kaolin and sodium carboxymethyl cellulose;
the appearance regulator is titanium dioxide.
5. The hydrogel elastic patch according to claim 1, wherein the crosslinking modifier is tartaric acid, citric acid, EDTA-2Na, EDTA-4Na, malic acid, lactic acid;
the preservative is at least one of benzalkonium chloride, methyl paraben, propyl paraben and phenoxyethanol;
the transdermal absorption penetration enhancer is at least one of isopropyl myristate, dimethyl sulfoxide and azone.
6. The hydrogel elastic patch as claimed in claim 1, wherein the method for preparing the polymer hydrogel with sustained release function comprises the following steps:
s1, mixing the sodium polyacrylate, the cross-linking agent, the cross-linking regulator and the appearance regulator with part of the solvent, stirring for 8-15 minutes at normal temperature, and uniformly dispersing to form phase A;
s2, adding the active pharmaceutical ingredients into partial solvent to be dissolved completely into a B phase at normal temperature;
s3, stirring the ionic inhibitor, the skin feel regulator, the transdermal absorption enhancer and the preservative for 15-20 minutes at normal temperature to form a mixed solution which is a phase C;
and S4, emulsifying the phase B and the phase C in a homogenizing emulsifying machine, pouring the emulsified liquid into a vacuum stirring kettle, mixing the phase A into the vacuum stirring kettle, and stirring to obtain the polymer hydrogel with the slow release function.
7. The method for preparing polymer hydrogel with sustained-release function according to claim 6, wherein in step S4, the rotation speed of emulsification is 4000r/min, and the emulsification time is 10-15 minutes; the stirring speed is 40-60r/min, and the stirring time is 10-15 minutes.
8. The hydrogel elastic patch as claimed in claim 1, wherein the hydrophobic auxiliary agent is at least one selected from the group consisting of a poly (fluoroalkyl acrylate) copolymer, silicone, fluorocarbon polymer, long-chain alkyl ester, and a copolymer thereof;
the waterproof material is made of thermoplastic elastomer or rubber.
9. The hydrogel elastic patch as claimed in claim 1 or 8, wherein the elastic material layer compounded with the hydrophobic auxiliary agent is prepared by the following method:
mixing the hydrophobic auxiliary agent and water according to the proportion of 6:94-12:88 to obtain a mixed solution, dyeing and fixing the elastic material, immersing the elastic material in the mixed solution for 5 minutes after finishing, pre-drying the elastic material for 2 minutes at the temperature of 120-140 ℃, and then sequentially drying the elastic material for 1 minute at the temperature of 150-155 ℃, 2 minutes at the temperature of 160-165 ℃ and 5 minutes at the temperature of 180-190 ℃ to obtain the elastic material layer of the composite hydrophobic auxiliary agent.
10. A method of making a hydrogel elastic patch according to claim 1 comprising the steps of: coating a macromolecule hydrogel layer with a slow release function on the elastic material layer, then covering a release covering layer, shearing, curing and packaging to obtain the product.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110271604.XA CN112870427A (en) | 2021-03-12 | 2021-03-12 | Hydrogel elastic patch and preparation method thereof |
PCT/CN2022/080351 WO2022188861A1 (en) | 2021-03-12 | 2022-03-11 | Polymer hydrogel with sustained-release function, and preparation method therefor and application thereof |
US18/033,371 US20230381371A1 (en) | 2021-03-12 | 2022-03-11 | Polymer hydrogel with slow-release function and preparation method and use thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110271604.XA CN112870427A (en) | 2021-03-12 | 2021-03-12 | Hydrogel elastic patch and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN112870427A true CN112870427A (en) | 2021-06-01 |
Family
ID=76041644
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202110271604.XA Pending CN112870427A (en) | 2021-03-12 | 2021-03-12 | Hydrogel elastic patch and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN112870427A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022188861A1 (en) * | 2021-03-12 | 2022-09-15 | 上海创始医疗科技(集团)股份有限公司 | Polymer hydrogel with sustained-release function, and preparation method therefor and application thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1360950A (en) * | 2000-12-28 | 2002-07-31 | 曹传波 | Production process of waterproof medical adhesive tape |
CN1827094A (en) * | 2006-04-07 | 2006-09-06 | 华中科技大学 | Gel type dexketoprofen plaster and method for preparing the same |
CN1857261A (en) * | 2006-03-30 | 2006-11-08 | 华中科技大学 | Aquogel type thiamazole plaster preparation |
US20110208101A1 (en) * | 2010-02-22 | 2011-08-25 | Keller Keith A | Compression Dressing |
CN207071113U (en) * | 2017-01-04 | 2018-03-06 | 苏州恒星医用材料有限公司 | A kind of elastoplast |
CN209019185U (en) * | 2017-11-06 | 2019-06-25 | 苏州康孚智能科技有限公司 | Utilize the absorbent article of close and distant waterpower control liquid directional profile |
CN110478519A (en) * | 2019-06-24 | 2019-11-22 | 武汉兵兵药业有限公司 | One kind is for soft tissue surface of a wound scar repair hydrogel dressing and preparation method thereof |
-
2021
- 2021-03-12 CN CN202110271604.XA patent/CN112870427A/en active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1360950A (en) * | 2000-12-28 | 2002-07-31 | 曹传波 | Production process of waterproof medical adhesive tape |
CN1857261A (en) * | 2006-03-30 | 2006-11-08 | 华中科技大学 | Aquogel type thiamazole plaster preparation |
CN1827094A (en) * | 2006-04-07 | 2006-09-06 | 华中科技大学 | Gel type dexketoprofen plaster and method for preparing the same |
US20110208101A1 (en) * | 2010-02-22 | 2011-08-25 | Keller Keith A | Compression Dressing |
CN207071113U (en) * | 2017-01-04 | 2018-03-06 | 苏州恒星医用材料有限公司 | A kind of elastoplast |
CN209019185U (en) * | 2017-11-06 | 2019-06-25 | 苏州康孚智能科技有限公司 | Utilize the absorbent article of close and distant waterpower control liquid directional profile |
CN110478519A (en) * | 2019-06-24 | 2019-11-22 | 武汉兵兵药业有限公司 | One kind is for soft tissue surface of a wound scar repair hydrogel dressing and preparation method thereof |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022188861A1 (en) * | 2021-03-12 | 2022-09-15 | 上海创始医疗科技(集团)股份有限公司 | Polymer hydrogel with sustained-release function, and preparation method therefor and application thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR101015491B1 (en) | Patch | |
JP5564469B2 (en) | Improved transdermal delivery system for rotigotine administration | |
FI104618B (en) | Process for preparing an adhesive transdermal drug delivery device | |
US20110300198A1 (en) | Hydrocolloid - essential oil patches | |
CA2258242A1 (en) | Device for topical treatment of acne and its method of manufacture | |
US20040156886A1 (en) | Sheet-like patch agent | |
US11311423B2 (en) | Facial patch | |
CN106074453B (en) | Lappaconitine Gel emplastrum and preparation method thereof | |
AU772863B2 (en) | Sheet-form adhesive preparation | |
KR20180058641A (en) | A Hydrogel Composition Excellent In Moisture Resistance And A Sheet Using The Composition | |
JP5089933B2 (en) | Water-containing pressure-sensitive adhesive composition and patch using the same | |
DE60126607T2 (en) | ELEMENT FOR APPLYING AN OINTMENT AND AN OINTMENT THAT USES THIS | |
CN112870427A (en) | Hydrogel elastic patch and preparation method thereof | |
JP4837915B2 (en) | Improved transdermal delivery system | |
CN112807484A (en) | Polymer hydrogel with slow release function and preparation method thereof | |
KR20000062348A (en) | Extremely flexible plaster acting dermally or transdermally, and method for producing same | |
KR100614090B1 (en) | Sheet-type packs | |
CN104955426A (en) | Patch for treatment of eyelid diseases containing clobetasol | |
JP2010064997A (en) | Patch and patch preparation | |
AU3340997A (en) | Device for topical treatment of acne and its method of manufacture | |
KR20110109250A (en) | The film-forming compositions based on polymers with hydrophilic components for the hydrophilic and hydrophobic drug delivery and process for preparing the same | |
WO2022188861A1 (en) | Polymer hydrogel with sustained-release function, and preparation method therefor and application thereof | |
WO2021002124A1 (en) | Moisturizing film cosmetic material | |
WO2022125624A1 (en) | Highly elastic patches and masks for delivery of therapeutic agents | |
JPH09268123A (en) | Cataplasm for local anesthesia |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210601 |
|
RJ01 | Rejection of invention patent application after publication |