CN112869907A

CN112869907A - Poison gas experimental apparatus for mouse

Info

Publication number: CN112869907A
Application number: CN202110031800.XA
Authority: CN
Inventors: 吴婷婷
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-01-11
Filing date: 2021-01-11
Publication date: 2021-06-01

Abstract

The invention discloses a toxic gas experimental device for mice, which relates to the field of medical experimental instruments and comprises an experimental box for containing the mice, wherein the experimental box comprises an experimental box, a first contrast box and a second contrast box, the experimental box, the first contrast box and the second contrast box are sequentially arranged and are isolated from each other, the experimental box comprises an experimental cabin and a recovery cabin which are arranged from top to bottom, the circumferential side wall of the experimental cabin is connected with an annular shell which is coaxially arranged, an annular channel communicated with a toxic gas supply source is formed between the annular shell and the side wall of the experimental cabin, the annular shell is arranged on the outer ring of the experimental cabin body, the original toxic gas fed from the top is changed into the toxic gas diffused from the periphery to the middle, the annular shell is matched with a gas conveying end to pre-diffuse the toxic gas at an input end and fully shunt, all spaces in the annular direction are covered, the toxic gas can be uniformly released into the cabin body, the toxic gas is uniformly distributed in the, effectively ensures that the detection concentration is close to the actual concentration in the cabin body and meets the error requirement.

Description

Poison gas experimental apparatus for mouse

Technical Field

The disclosure relates to the field of medical experimental instruments, in particular to a toxic gas experimental device for mice.

Background

The statements in this section merely provide background information related to the present disclosure and may not necessarily constitute prior art.

When some toxic gases (nitrogen dioxide, sulfur dioxide and the like) influence the relevant experiments of the vital signs of the mice, a toxic gas experiment box is usually adopted, a group of mice are put into the experiment box, then air mixed with the toxic gases is uniformly introduced into the experiment box, after the experiments are carried out for a set time, the mice are taken out, the vital signs of the mice are detected and recorded, and the influence of the toxic gases on the vital signs of the mice under different parameters is obtained.

When the existing toxic gas box injects toxic gas into an experiment cabin body, the gas supply end is communicated with the gas exhaust end, the gas supply end injects the toxic gas from the top, the gas exhaust port and the gas supply are less blocked, so that a main flow path of the toxic gas is on a connecting line of the gas supply end and the gas exhaust port to form convection, the toxic gas is difficult to be fully dispersed in an experiment area, the distribution of the toxic gas is uneven, a high-concentration area and a low-concentration area exist, a mouse tends to be at a lower position of concentration, and an error exists between the measured concentration and the concentration at the actual position of the mouse.

The inventor finds that the main mode for solving the problem of uneven concentration distribution in the toxic gas experiment box at present is to increase a fan, enlarge the sectional area of a toxic gas spray head and the like in a cabin body, wherein one mode is to increase a disturbance structure such as the fan, and the other mode is to enlarge the area of the spray head, so that the output position of the toxic gas spray head is larger, and a larger range is covered; however, the disturbance structure occupies the space of the cabin body inside the toxic gas box, and the disturbance effect of the disturbance structure enables the periphery of the disturbance structure to be a high-concentration and low-concentration crossed area, although most of the space in the cabin is promoted to be an area with uniform concentration, the movement of the mouse still tends to a low-concentration area, and the detection concentration is still not guaranteed to be close to the actual inhalation concentration of the mouse; and the mode of expanding the toxic gas spray head is adopted, and the upper limit specification of the toxic gas spray head is certain, so that the complete coverage of the toxic gas experiment cabin body with larger volume cannot be realized.

Disclosure of Invention

The utility model discloses a defect to prior art exists is directed against, a poison gas experimental apparatus is used to mouse is provided, arrange annular casing in experiment cabin body outer lane, change original poison gas of puting in from the top, change into from diffusing all around to the centre, annular casing cooperation gas transmission end can carry out the diffusion in advance with the poison gas of input, fully shunt, cover all spaces of hoop, can make in the poison gas evenly releases gets into the cabin, it is even in the internal distribution of cabin, need not to arrange the disturbance structure in the cabin, the whole convenient operation, it is close and satisfy the error demand effectively to guarantee that its concentration of detection is close with the internal actual concentration of cabin.

In order to realize the purpose, the following technical scheme is adopted:

the utility model provides a poison gas experimental apparatus for mouse, including the experimental box that is used for holding the mouse, the experimental box is including setting gradually and the experiment box of mutual isolation, the control box two that has control chamber one and have control chamber two, the experiment box is including being the experiment cabin and the recovery cabin of arranging from top to bottom, experiment cabin circumference lateral wall is connected with the annular housing of coaxial arrangement, form the annular channel of intercommunication poison gas supply source between annular housing and the experiment cabin lateral wall, experiment cabin hoop evenly distributed has four at least air vents that all communicate the annular channel, be equipped with the intercommunicating pore on the space bar between experiment cabin and the recovery cabin, be equipped with the gas vent that is used for communicateing recovery plant on the recovery cabin lateral wall.

Furthermore, the test box is transparent cylindric, and experiment cabin, recovery cabin, comparison box one and comparison box two arrange along the axial in proper order, and the experiment cabin top is equipped with the opening that is used for getting to put experimental group mouse, and the opening cooperation has the top cap for the shutoff or open the opening.

Furthermore, the side walls of the first control box and the second control box are respectively provided with a feeding opening for feeding mice in a control group, and the feeding openings are respectively provided with a baffle door for plugging or opening the feeding openings.

Furthermore, the annular shell is provided with air inlets communicated with the annular channel, and the two air inlets are respectively positioned at two ends of the diameter of the annular shell.

Furthermore, the vent hole penetrates through the side wall of the experiment chamber to communicate the annular channel with the experiment cavity in the experiment chamber, and the length of the vent hole is longer and the sectional area of the opening of the vent hole is larger along the upward direction of the experiment chamber.

Furthermore, a plurality of communicating holes are arranged on the partition plate in an array mode, the partition plate is used for supporting the experimental group mouse, and the diameter of the communicating holes is gradually increased along the direction from the radius to the circle center of the partition plate.

Furthermore, retrieve the inside recovery chamber that is equipped with the inside experiment chamber of intercommunication experiment cabin of cabin, be equipped with the two gas vents that the chamber was retrieved in the intercommunication on retrieving the cabin lateral wall, two gas vents are located the both ends of retrieving a diameter of cabin respectively, all are used for communicateing poison gas recovery plant.

Furthermore, a plurality of circulation holes are formed in the side walls of the first contrast box and the second contrast box and are used for communicating the first contrast cavity with the external environment and the second contrast cavity with the external environment.

Furthermore, a circulating fan is arranged in at least one circulating hole of the first comparison box, and a circulating fan is arranged in at least one circulating hole of the second comparison box.

Further, an air inlet fan is arranged at the position, where the annular channel is butted with an air inlet of an external poison gas supply source.

Compared with the prior art, the utility model has the advantages and positive effects that:

(1) arrange annular housing in experiment cabin body outer lane, change original poison gas of puting in from the top, change into from diffusing all around to the centre, annular housing cooperation gas transmission end can be with the poison gas of input in advance diffusion, fully shunts, cover all spaces of hoop, can make in the poison gas evenly releases enters into the cabin, it is even to distribute in the cabin body, need not to arrange the disturbance structure in the cabin body, whole convenient operation, it is close and satisfy the error demand effectively to guarantee that its concentration that detects is close with the interior actual concentration of cabin.

(2) Arrange three layer construction about well, the top is the experiment cabin, and the middle part and the lower part cabin body are the contrast group, wholly are the transparent plate preparation, and the leakproofness can satisfy the demand, and transparent housing can be convenient observe the internal conditions.

(3) The annular channel structure can change the toxic gas from the traditional single-point output to the annular large-area input, and compared with the traditional mode of entering from the bottom, the toxic gas can enter the cabin body from more positions; the channel structure enters the cabin body through the dense small holes formed in the outer wall of the cabin body, so that the mode of diffusing poison gas from the periphery to the middle is realized, even if a mouse is close to the periphery of the cabin body, the poison gas can directly penetrate through the dense lower holes to cover the position of the mouse, the poison gas environment with the environment of the mouse being uniform in concentration is ensured, and the detection data are the same as the actual concentration data in the cabin body.

(4) The outside cover of the cabin body of top experiment group is equipped with annular shell structure, as the middle channel structure of poison gas supply source and experimental cabin body, annular shell structure cooperation cabin body outer wall can form annular channel, after the poison gas gets into annular shell, disperse in advance along annular channel, and through the intensive aperture that sets up on the cabin body outer wall get into experimental cabin internal, then after the sufficient dispersion in the cabin body, pass the space bar and discharge from the gas vent below, improve the even degree that gets into the distribution of poison gas in the experimental cavity.

(5) The top of the experimental group is provided with the cover body, so that the experimental group is convenient to disassemble, assemble and clean quickly; the side surface of the control group is provided with an opening and a baffle plate which are used as an inlet and an outlet for the control group test to take and place the mouse, and the side surface is also provided with an air hole, so that the control group is in a normal air environment under the same experimental condition.

(6) Along the circumferencial direction of annular passage, along with being mingled with the air of toxic gas and flowing gradually, its pressure reduces gradually, and it is higher more to be close to its atmospheric pressure of air inlet more, and through the cross sectional area of control air vent, the air input of the air vent of the position far away from the air inlet is guaranteed to guarantee that its toxic gas concentration is close with the air vent position concentration that is close to the air inlet position, realizes getting into the experiment intracavity gas and keeps evenly.

Drawings

The accompanying drawings, which are included to provide a further understanding of the disclosure, illustrate embodiments of the disclosure and together with the description serve to explain the disclosure and are not to limit the disclosure.

Fig. 1 is an overall schematic view of a toxic gas experimental apparatus for mice in embodiment 1 of the present disclosure;

FIG. 2 is a schematic external view of a toxic gas experimental apparatus for mice in example 1 of the present disclosure;

FIG. 3 is a schematic view of the whole section of a toxic gas experimental apparatus for mice in example 1 of the present disclosure;

fig. 4 is a schematic partial cross-sectional view of a toxic gas experimental apparatus for mice in embodiment 1 of the present disclosure.

In the figure, 1-test chamber, 2-test box, 3-contrast chamber I, 4-contrast chamber II, 5-annular shell, 6-annular channel, 7-test chamber, 8-vent hole, 9-recovery chamber, 10-partition plate, 11-top cover, 12-air inlet, 13-air outlet, 14-communication hole, 15-circulation hole and 16-baffle door.

Detailed Description

It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present disclosure. As used herein, the singular forms "a", "an", and/or "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof;

for convenience of description, the words "up", "down", "left" and "right" in this disclosure, if any, merely indicate that the directions of movement are consistent with those of the figures themselves, and are not limiting in structure, but merely facilitate the description of the invention and simplify the description, rather than indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the present disclosure.

As introduced in the background art, the existing toxic gas is difficult to be fully dispersed in an experimental area, the toxic gas is unevenly distributed, a high-concentration area and a low-concentration area exist, a mouse tends to be at a position with lower concentration, and an error exists between the measured concentration and the concentration of the position where the mouse is actually located.

Example 1

In a typical embodiment of the present disclosure, as shown in fig. 1 to 4, a toxic gas experimental apparatus for mice is provided.

The main body is of a cylindrical test box 1 structure, and the test box comprises an experiment box, a comparison box I with a comparison cavity I and a comparison box II with a comparison cavity II which are sequentially arranged and mutually isolated;

specifically, the proof box divide into experiment box 2, comparison box one and comparison box two triplexes along the axial in proper order, and the triplex is isolated each other, avoids producing the interact between experiment group and the comparison group, piles up the setting with it, can guarantee that its other parameters except that the poison gas environment are unanimous.

Corresponding cavities are correspondingly arranged in the experiment box, the first control box and the second control box, and the experiment group mouse or the control group mouse is accommodated in the cavities.

To contrast box one and contrast box two, its inside contrast chamber one 3, contrast chamber two 4 of being equipped with respectively, holds first group contrast group mouse in the contrast chamber one, holds second group contrast mouse in the contrast chamber two, sets up the multiunit contrast that two sets of contrast groups can realize the experimentation, overcomes in the traditional experimentation one a pair of contrast easily to receive the drawback that environmental impact contrast group became invalid.

It can be understood that the structure of the first control box and the second control box is completely the same, which can ensure that two groups of control groups meeting the experimental requirements are formed.

Specifically, for the structure of the first contrast box and the second contrast box, the side walls of the first contrast box and the second contrast box are respectively provided with a feeding opening for feeding mice of a contrast group, and the feeding openings are respectively provided with a baffle door 16 for plugging or opening the feeding openings.

The whole transparent construction that is of experimental box, the condition of observing inside mouse that can be clear in this embodiment, can choose for use transparent acrylic plate preparation, and its thickness and transparency homoenergetic can satisfy the demand of experiment to guarantee its gas tightness.

For controlling the environment of the contrast group, the mouse of the contrast group is in a normal air environment, and the side walls of the contrast box I and the contrast box II are respectively provided with a plurality of circulation holes 15 which are used for communicating the contrast cavity I with the external environment, and the contrast cavity II with the external environment.

Furthermore, because a group of a plurality of mice are arranged in each control cavity and are relatively dense, the circulating fan is arranged to ensure that the air quality of the environment where the mice are located is good;

and a circulating fan is arranged in at least one circulating hole of the first comparison box, and a circulating fan is arranged in at least one circulating hole of the second comparison box.

The air in the control cavity is actively disturbed through the circulating fan, so that the circulation environment of the air is ensured, and the quality of the air in the control cavity is kept good.

To the configuration of the experimental box of input experimental group mouse, the experimental box is including being experiment cabin and the recovery cabin of arranging from top to bottom, be equipped with the intercommunicating pore 14 on the space bar 10 between experiment cabin and the recovery cabin, the mouse is put in the experiment cabin, the space bar is as the backup pad that bears the mouse, poison gas pours into the experiment cabin into, then the dispersion is in the experiment cabin back, get into the recovery cabin through the intercommunicating pore, then is taken out, make the poison gas concentration in the experiment cabin keep dynamic stability, make the mouse can evenly inhale the poison gas.

In order to solve the problem of uneven toxic gas distribution in the traditional toxic gas box test area, in the embodiment, the test chamber is specially configured;

the circumferential side wall of the experiment chamber is connected with an annular shell 5 which is coaxially arranged, an annular channel 6 which is communicated with a poison gas supply source is formed between the annular shell and the side wall of the experiment chamber, at least four vent holes 8 which are communicated with the annular channel are uniformly distributed in the circumferential direction of the experiment chamber, and an exhaust port 13 which is used for being communicated with recovery equipment is arranged on the side wall of the recovery chamber.

It will be appreciated that the number of ventilation holes is selected according to the actual diameter of the test chamber, and that as the diameter of the test chamber increases, the number of ventilation holes may be increased, e.g. to 20, 8, etc.

To the input of mouse, in order to make things convenient for the mouse to input the operation, in this embodiment, throw the position of putting into the experiment cabin to the mouse and dispose, the experiment cabin top is equipped with the opening that is used for getting to put the experiment group mouse, and the opening cooperation has top cap 11 for the shutoff or open the opening.

The top of the experimental group is provided with the cover body, so that the experimental group is convenient to disassemble, assemble and clean quickly; the side surface of the control group is provided with an opening and a baffle plate which are used as an inlet and an outlet for the control group test to take and place the mouse, and the side surface is also provided with an air hole, so that the control group is in a normal air environment under the same experimental condition.

Further, the annular shell is provided with air inlets 12 communicated with the annular channel, and the two air inlets are respectively positioned at two ends of the diameter of the annular shell;

the outside cover of the cabin body of top experiment group is equipped with annular shell structure, as the middle channel structure of poison gas supply source and experimental cabin body, annular shell structure cooperation cabin body outer wall can form annular channel, after the poison gas gets into annular shell, disperse in advance along annular channel, and through the intensive aperture that sets up on the cabin body outer wall get into experimental cabin internal, then after the sufficient dispersion in the cabin body, pass the space bar and discharge from the gas vent below, improve the even degree that gets into the distribution of poison gas in the experimental cavity.

The air vent runs through the side wall of the experiment chamber to communicate the annular channel with the experiment chamber 7 in the experiment chamber, and the distance from the air inlet to the annular channel is longer and the opening sectional area of the air vent is larger.

The annular channel structure can change the toxic gas from the traditional single-point output to the annular large-area input, and compared with the traditional mode of entering from the bottom, the toxic gas can enter the cabin body from more positions.

The poison gas injected into the annular channel enters the cabin body through the dense small holes formed in the outer wall of the cabin body, so that the mode of diffusing poison gas from the periphery to the middle is realized, even if a mouse is close to the periphery of the cabin body, the poison gas can directly penetrate through the dense lower holes to cover the position of the mouse, the poison gas environment with the environment being uniform in concentration is ensured, and the detection data are the same as the actual concentration data in the cabin body.

It should be noted that, along the circumferential direction of the annular channel, along with the air mixed with toxic gas flows gradually, the pressure of the annular channel is reduced gradually, the air pressure of the annular channel is higher as the annular channel is closer to the air inlet, and the air inflow of the air vent at the position far away from the air inlet is ensured by controlling the cross-sectional area of the air vent, so that the concentration of the toxic gas is close to that of the air vent close to the air inlet, and the gas entering the experimental cavity is kept uniform.

For the cross-sectional shape of the vent hole, a rectangular through hole as shown in the figure can be selected, a circular through hole structure can be selected, the processing can be conveniently carried out, and the cross-sectional area during the processing is conveniently controlled to meet the requirement.

The partition plate is provided with a plurality of communicating holes in an array mode and used for supporting the mice in the experimental group, and the diameter of each communicating hole is gradually increased along the direction from the radius to the circle center;

similarly, the diameter of the communicating hole far away from the vent hole is increased, so that the communicating hole can adapt to different air pressure distribution ranges, and toxic gas entering the experiment cabin can uniformly enter the recovery cabin.

The recovery cabin is internally provided with a recovery cavity 9 communicated with the experiment cavity in the experiment cabin, the side wall of the recovery cabin is provided with two exhaust ports communicated with the recovery cavity, and the two exhaust ports are respectively positioned at two ends of one diameter of the recovery cabin and are all used for being communicated with toxic gas recovery equipment.

An annular shell is arranged on the outer ring of the experimental cabin body, the original toxic gas put from the top is changed into the toxic gas diffusion from the periphery to the middle, and the annular shell is matched with the gas transmission end to pre-diffuse the toxic gas at the input end and fully shunt the toxic gas;

the split toxic gas is diffused into the middle experiment cabin from the periphery, all circumferential spaces are covered, the toxic gas can be uniformly released into the cabin body, the distribution in the cabin body is uniform, the dynamic stability of the concentration of the toxic gas is kept, a disturbance structure does not need to be arranged in the cabin body, the whole operation is convenient, the detection concentration of the split toxic gas is effectively guaranteed to be close to the actual concentration in the cabin body, and the error requirement is met.

The above description is only a preferred embodiment of the present disclosure and is not intended to limit the present disclosure, and various modifications and changes may be made to the present disclosure by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present disclosure should be included in the protection scope of the present disclosure.

Claims

1. The utility model provides a poison gas experimental apparatus for mouse, a serial communication port, including the experimental box that is used for holding the mouse, the experimental box is including setting gradually and the experiment box of mutual isolation, the control box one that has control chamber one and the control box two that has control chamber two, the experiment box is including being the experiment cabin and the recovery cabin of arranging from top to bottom, experiment cabin circumference lateral wall is connected with the annular casing of coaxial arrangement, form the annular channel who communicates the poison gas supply source between annular casing and the experiment cabin lateral wall, experiment cabin hoop evenly distributed has at least four air vents that all communicate annular channel, be equipped with the intercommunicating pore on the space bar between experiment cabin and the recovery cabin, be equipped with the gas vent that is used for communicateing recovery plant on the recovery cabin lateral wall.

2. The apparatus of claim 1, wherein the test chamber is a transparent cylinder, the test chamber, the recycling chamber, the first control box and the second control box are sequentially arranged along the axial direction, the top of the test chamber is provided with an opening for taking and placing the mice in the experimental group, and the opening is matched with a top cover for sealing or opening the opening.

3. The toxic gas experimental device for mice as claimed in claim 2, wherein the side walls of the first control box and the second control box are respectively provided with a feeding opening for feeding control mice, and the feeding openings are respectively provided with a baffle door for blocking or opening the feeding openings.

4. The apparatus of claim 1, wherein the annular housing has an inlet opening communicating with the annular channel, and the two inlet openings are located at two ends of the diameter of the annular housing.

5. The mouse gas poisoning test apparatus of claim 4, wherein the vent hole penetrates through a side wall of the test chamber to communicate the annular passage with the test chamber inside the test chamber, and the cross-sectional area of the opening of the vent hole is larger along the length of the gas inlet and the length of the vent hole is longer along the circumference of the test chamber.

6. The experimental device for mouse poison gas as claimed in claim 1, wherein a plurality of communication holes are arranged on the partition plate in an array, the partition plate is used for supporting the experimental group mouse, and the diameter of the communication holes is gradually increased along the direction from the radius to the center of the circle of the partition plate.

7. The apparatus of claim 1, wherein the recovery chamber is provided with a recovery cavity communicating with the experimental chamber inside the experimental chamber, and the sidewall of the recovery chamber is provided with two exhaust ports communicating with the recovery cavity, the two exhaust ports are respectively located at two ends of a diameter of the recovery chamber and are used for communicating with the toxic gas recovery device.

8. The apparatus of claim 1, wherein the first control box and the second control box each have a plurality of circulation holes formed in a sidewall thereof for communicating the first control chamber with an external environment and the second control chamber with the external environment.

9. The apparatus of claim 8, wherein a circulation fan is installed in at least one of the circulation holes of the first control box, and a circulation fan is installed in at least one of the circulation holes of the second control box.

10. The apparatus of claim 1, wherein an air inlet fan is disposed at a position where the annular channel is abutted against an air inlet of an external poison gas supply source.