CN112845046A - Preparation device of slow-release nano-drug for inhibiting tumor recurrence and metastasis - Google Patents
Preparation device of slow-release nano-drug for inhibiting tumor recurrence and metastasis Download PDFInfo
- Publication number
- CN112845046A CN112845046A CN202110017774.5A CN202110017774A CN112845046A CN 112845046 A CN112845046 A CN 112845046A CN 202110017774 A CN202110017774 A CN 202110017774A CN 112845046 A CN112845046 A CN 112845046A
- Authority
- CN
- China
- Prior art keywords
- sieve
- screening
- primary
- pipe
- stage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 41
- 229940079593 drug Drugs 0.000 title claims abstract description 41
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 18
- 206010027476 Metastases Diseases 0.000 title claims abstract description 17
- 230000002401 inhibitory effect Effects 0.000 title claims abstract description 17
- 230000009401 metastasis Effects 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 238000012216 screening Methods 0.000 claims abstract description 64
- 239000000463 material Substances 0.000 claims abstract description 55
- 239000012528 membrane Substances 0.000 claims abstract description 41
- 239000002105 nanoparticle Substances 0.000 claims abstract description 24
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims abstract description 14
- 235000017491 Bambusa tulda Nutrition 0.000 claims abstract description 14
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims abstract description 14
- 241001330002 Bambuseae Species 0.000 claims abstract description 13
- 239000011425 bamboo Substances 0.000 claims abstract description 13
- 238000007599 discharging Methods 0.000 claims description 33
- 238000007873 sieving Methods 0.000 claims description 17
- 239000011148 porous material Substances 0.000 claims description 16
- 238000003860 storage Methods 0.000 claims description 16
- 230000002146 bilateral effect Effects 0.000 claims description 13
- 239000002245 particle Substances 0.000 abstract description 12
- 238000013268 sustained release Methods 0.000 abstract description 11
- 239000012730 sustained-release form Substances 0.000 abstract description 11
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 239000012876 carrier material Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 208000028659 discharge Diseases 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 201000007270 liver cancer Diseases 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 241000209128 Bambusa Species 0.000 description 1
- 208000007660 Residual Neoplasm Diseases 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000003980 solgel method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
- B07B1/28—Moving screens not otherwise provided for, e.g. swinging, reciprocating, rocking, tilting or wobbling screens
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
- B07B1/46—Constructional details of screens in general; Cleaning or heating of screens
- B07B1/4609—Constructional details of screens in general; Cleaning or heating of screens constructional details of screening surfaces or meshes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B2201/00—Details applicable to machines for screening using sieves or gratings
- B07B2201/04—Multiple deck screening devices comprising one or more superimposed screens
Abstract
The invention relates to the technical field of drug production, and particularly discloses a preparation device of a sustained-release nano-drug for inhibiting tumor recurrence and metastasis, which comprises a nano-particle grading and screening device; the nanoparticle classifying and screening device comprises a primary feeding pipe; the one-level inlet pipe bottom left and right sides is connected with first shunt tube and second shunt tube, and the bottom of first shunt tube and second shunt tube communicates first sieve section of thick bamboo and second sieve section of thick bamboo respectively, and the inside of first sieve section of thick bamboo and second sieve section of thick bamboo all is provided with first sieve material chamber and second sieve material chamber, and the one-level row of the bottom one side in two first sieve material chambers all communicates the slope structure expects the pipe, and the bottom that the one-level was arranged the material pipe communicates one-level secondary sieve material cylinder. The mixed nanoparticles are subjected to primary screening through the primary screening membranes in the first screening cylinder and the second screening cylinder, coarser particles are screened again through the primary screening membrane in the primary secondary screening cylinder, and secondary screening is performed through the secondary screening membrane in the secondary screening cylinder, so that the graded screening of the nanoparticles is realized.
Description
Technical Field
The invention relates to the technical field of drug production, in particular to a preparation device of a slow-release nano-drug for inhibiting tumor recurrence and metastasis.
Background
Primary liver cancer is the third leading cause of death of tumors in the world and china, and hepatocellular carcinoma accounts for 90% of primary liver cancer in china. A drug sustained-release system is constructed, a material which is nontoxic to a human body, has good biocompatibility and biodegradability is used as a drug sustained-release carrier, the drug sustained-release carrier is combined with a drug in a physical adsorption or chemical adsorption mode, drug delivery is carried out on the residual tumor of the liver after operation, drug molecules are continuously and slowly released in the human body at a controllable speed and at an appropriate concentration through diffusion action, osmosis action and other modes, effective blood concentration is achieved, the acting time of the drug in the human body is prolonged, the drug delivery frequency is obviously reduced, particularly the drug utilization rate can reach more than 80%, and the treatment effect is obviously improved while the toxicity and the side effect of the drug are effectively reduced.
The drug sustained-release carrier material is an important component of a drug sustained-release system, and not only can determine the drug-loading performance of the drug sustained-release carrier material, but also can influence the drug sustained-release performance of the drug sustained-release carrier material. The hollow structure material is a porous material with large internal cavities, and is an ideal drug sustained-release carrier due to the characteristics of large specific surface area, low density, large capacity and carrying capacity and the like. In the production of nano-drugs, the particle size of drug particles is often required to be consistent, and the commonly used manufacturing methods of nano-drugs include a chemical reduction method, a vapor deposition method, a sol-gel method and the like, and because the reaction conditions influence and the reaction process is difficult to accurately control, the methods are difficult to obtain nano-drug particles with uniform particle size, so that the nano-drug particles are classified and screened by a screening device, and the nano-drugs with uniform particle size can be obtained as long as the pore size of the screening device is consistent and reaches the nano-scale.
The existing nanoscale drug particle screening device is usually mainly composed of a support body and a nanometer screening membrane, and when the device is actually used, the device can only screen the nanometer drug particles with one pore diameter once due to the simple structure, so that the screening efficiency is not high, and the device needs to be improved.
Disclosure of Invention
The invention aims to provide a preparation device of a slow-release nano-drug for inhibiting tumor recurrence and metastasis, which aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: a preparation device of slow-release nano-drug for inhibiting tumor recurrence and metastasis comprises a nano-particle grading and screening device; the nanoparticle classifying and screening device comprises a primary feeding pipe; the left side and the right side of the bottom of the primary feeding pipe are connected with a first shunt pipe and a second shunt pipe, the bottom ends of the first shunt pipe and the second shunt pipe are respectively communicated with a first sieve barrel and a second sieve barrel, a first sieve cavity and a second sieve cavity are respectively arranged inside the first sieve barrel and the second sieve barrel, the first sieve cavity is arranged at the top end of the second sieve cavity, one side of the bottom of each of the two first sieve cavities is communicated with a primary discharging pipe of an inclined structure, the two primary discharging pipes are symmetrically arranged in a left-right mode, and the bottom end of each primary discharging pipe is communicated with a primary secondary sieve barrel;
the bottom ends of the two second material sieving cavities are communicated with a second-stage material feeding pipe, the bottom ends of the two second-stage material feeding pipes are communicated with a second-stage sieving drum through the second-stage material feeding pipes, and the two second-stage material feeding pipes are arranged in a bilateral symmetry manner; a third screening cavity and a fourth screening cavity are arranged in the secondary screening drum from top to bottom; one side of the bottom of the third screening cavity is communicated with a secondary discharging pipe, and the bottom end of the secondary discharging pipe is communicated with a secondary storage box; the bottom of the fourth screening cavity is communicated with a third-level discharging pipe, and the third-level discharging pipe is communicated with a third-level storage box.
In a preferable scheme of the invention, the first shunt pipe and the second shunt pipe are obliquely arranged on the left side and the right side of the primary feeding pipe in a bilateral symmetry mode.
As a preferable scheme of the invention, the first screening cavity and the second screening cavity are separated by a primary screening membrane with an inclined structure, and the primary screening membranes in the first screening cylinder and the second screening cylinder are arranged in bilateral symmetry.
As a preferable scheme of the invention, the third screening cavity and the fourth screening cavity are separated by a secondary screening membrane with an inclined structure, and the secondary screening membranes in the two secondary screening cylinders are arranged in bilateral symmetry.
As a preferred scheme of the invention, a primary sieving membrane with an inclined structure is also installed inside the primary secondary sieving cylinder, and the primary sieving membrane divides the primary secondary sieving cylinder into a primary discharging cavity and a secondary discharging cavity from top to bottom.
As a preferred scheme of the invention, a primary material pipe is arranged on one side of the bottom of the primary discharging cavity, and the bottom end of the primary material pipe is communicated with a primary material storage box; the bottom of the secondary discharging cavity is communicated with the top end of the secondary screen drum through a secondary feeding pipe.
As a preferable scheme of the present invention, the bottom of each of the first screen cylinder and the second screen cylinder is provided with a fixed pillar, a horizontal pillar is connected between the fixed pillar and the second-stage screen cylinder, and the bottom end of the fixed pillar is provided with a fixed base.
As a preferable scheme of the present invention, the first sieve drum, the second sieve drum, the primary secondary sieve drum and the secondary sieve drum are all provided with a vibration motor.
As a preferable scheme of the present invention, the first-stage sieve membrane and the second-stage sieve membrane are both provided with a nano-sieve pore, and the pore size of the nano-sieve pore on the first-stage sieve membrane is larger than the pore size of the nano-sieve pore on the second-stage sieve membrane.
Compared with the prior art, the invention has the beneficial effects that:
the preparation device of the sustained-release nano-drug for inhibiting tumor recurrence and metastasis mainly comprises a nano-particle grading and screening device, wherein the device mainly comprises a first sieve cylinder, a second sieve cylinder, a secondary sieve cylinder and a secondary sieve cylinder; during the in-service use, carry out one-level screening work to the nanoparticle of mixing through the one-level sieve membrane in first sieve section of thick bamboo and the second sieve section of thick bamboo, screen comparatively thick granule once more via the one-level sieve membrane in the one-level secondary sieve section of thick bamboo, carry out second grade screening work to it through the second grade sieve membrane in the second grade sieve section of thick bamboo to this realizes the hierarchical screening work of nanoparticle, and the integrated form design of integration has effectually improved the production efficiency and the quality of nanoparticle.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
fig. 2 is a schematic structural diagram of the primary sieving membrane of the present invention.
In the figure: 1. a first-stage feeding pipe; 2. a first shunt pipe; 3. a second shunt pipe; 4. a first screen cylinder; 5. a second screen cylinder; 6. a first sieve cavity; 7. a second sieve cavity; 8. primary screening membrane; 9. a primary discharge pipe; 10. a primary secondary screening cylinder; 11. a secondary feeding pipe; 12. a secondary screen drum; 13. a third sieve material cavity; 14. a fourth sieve material cavity; 15. a second-stage sieving membrane; 16. a secondary discharge pipe; 17. a secondary material storage box; 18. a third-stage discharge pipe; 19. a third-stage material storage box; 20. a primary discharge chamber; 21. a secondary discharging cavity; 22. a primary material pipe; 23. a primary material storage box; 24. a secondary feeding pipe; 25. fixing a strut; 26. a horizontal strut; 27. a fixed base; 28. a vibration motor.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "vertical", "upper", "lower", "horizontal", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of describing the present invention and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.
In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
Referring to fig. 1-2, the present invention provides a technical solution: a preparation device of slow-release nano-drug for inhibiting tumor recurrence and metastasis comprises a nano-particle grading and screening device; the nanoparticle classifying and screening device comprises a primary feeding pipe 1; the left side and the right side of the bottom of the primary feeding pipe 1 are connected with a first shunt pipe 2 and a second shunt pipe 3, the bottom ends of the first shunt pipe 2 and the second shunt pipe 3 are respectively communicated with a first screen drum 4 and a second screen drum 5, a first screen material cavity 6 and a second screen material cavity 7 are respectively arranged inside the first screen drum 4 and the second screen drum 5, the first screen material cavity 6 is arranged at the top end of the second screen material cavity 7, one side of the bottom of each of the two first screen material cavities 6 is communicated with a primary discharging pipe 9 with an inclined structure, the two primary discharging pipes 9 are symmetrically arranged left and right, and the bottom end of the primary discharging pipe 9 is communicated with a primary secondary screen drum 10;
the bottom ends of the two second material sieving cavities 7 are communicated with a secondary material feeding pipe 11, the bottom ends of the two secondary material feeding pipes 11 are communicated with a secondary sieving cylinder 12 through the secondary material feeding pipes 11, and the two secondary material feeding pipes 11 are arranged in bilateral symmetry; a third screening cavity 13 and a fourth screening cavity 14 are arranged in the secondary screening drum 12 from top to bottom; one side of the bottom of the third screening cavity 13 is communicated with a secondary discharging pipe 16, and the bottom end of the secondary discharging pipe 16 is communicated with a secondary storage box 17; the bottom of the fourth screening cavity 14 is communicated with a third-level discharging pipe 18, and the third-level discharging pipe 18 is communicated with a third-level storage box 19.
Furthermore, the first shunt pipe 2 and the second shunt pipe 3 are arranged on the left side and the right side of the first-stage feeding pipe 1 in a bilateral symmetry inclined mode.
Further, first sieve material chamber 6 and second sieve material chamber 7 are separated through the one-level sieve membrane 8 of slope structure between, and the one-level sieve membrane 8 bilateral symmetry of first sieve section of thick bamboo 4 and the inside of second sieve section of thick bamboo 5 sets up.
Further, third sieve material chamber 13 and fourth sieve material chamber 14 are separated through the second grade sieve membrane 15 of slope structure, and the inside second grade sieve membrane 15 bilateral symmetry of two second grade sieve section of thick bamboos 12 sets up.
Further, the inside of the first-stage secondary screening cylinder 10 is also provided with a first-stage screening membrane 8 with an inclined structure, and the first-stage screening membrane 8 divides the first-stage secondary screening cylinder 10 into a first-stage discharging cavity 20 and a second-stage discharging cavity 21 from top to bottom.
Further, a primary material pipe 22 is arranged on one side of the bottom of the primary discharging cavity 20, and the bottom end of the primary material pipe 22 is communicated with a primary material storage box 23; the bottom of the secondary discharging cavity 21 is communicated with the top end of the secondary screen drum 12 through a secondary feeding pipe 24.
Further, the bottom of the first screen drum 4 and the bottom of the second screen drum 5 are both provided with a fixed pillar 25, a horizontal pillar 26 is connected between the fixed pillar 25 and the second-stage screen drum 12, and a fixed base 27 is installed at the bottom end of the fixed pillar 25.
Further, the first screen drum 4, the second screen drum 5, the primary secondary screen drum 10 and the secondary screen drum 12 are all provided with a vibration motor 28.
Further, the first-stage sieve membrane 8 and the second-stage sieve membrane 15 are both provided with a nano-sieve pore, and the pore size of the nano-sieve pore on the first-stage sieve membrane 8 is larger than that of the nano-sieve pore on the second-stage sieve membrane 15.
The working principle is as follows: during actual use, mixed nanoparticles to be screened are added into the device through the first-stage feeding pipe 1, the mixed nanoparticles are respectively guided into the first screen cylinder 4 and the second screen cylinder 5 through the first shunt pipe 2 and the second shunt pipe 3, the mixed nanoparticles are subjected to first-stage screening work through the first-stage screen membrane 8 in the first screen cylinder 4 and the second screen cylinder 5, the screened finer nanoparticles are guided into the second-stage screen cylinder 12 through the second-stage feeding pipe 11, the coarser particles are discharged into the first-stage secondary screen cylinder 10 through the first-stage discharging pipe 9, the coarser particles are screened again through the first-stage screen membrane 8 in the first-stage secondary screen cylinder 10, the screened fine particles are guided into the second-stage screen cylinder 12 through the second-stage feeding pipe 24, and the coarser particles are guided out to the first-stage storage box 23 through the first-stage feeding pipe 22 for storage; after the nano particles enter the secondary sieve drum 12, secondary screening work is carried out on the nano particles through a secondary sieve membrane 15 in the secondary sieve drum 12, the screened qualified nano particles are discharged to a secondary storage box 17 through a secondary discharge pipe 16, and the rest nano particles are discharged to a tertiary discharge box 19 through a tertiary discharge pipe 18 for storage, so that the multistage screening work of the nano particles is completed; the vibrating motors 28 arranged on the first screen drum 4, the second screen drum 5, the primary secondary screen drum 10 and the secondary screen drum 12 play an effective auxiliary acceleration role in the classification screening work of the nano particles, and the separation screening efficiency and quality are improved.
It is worth noting that: the whole device realizes control over the device through the controller, and because the equipment matched with the controller is common equipment, the device belongs to the existing mature technology, and the electrical connection relation and the specific circuit structure are not repeated.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (9)
1. A preparation device of slow-release nano-drugs for inhibiting tumor recurrence and metastasis is characterized in that: comprises a nano-particle grading and screening device; the nanoparticle classifying and screening device comprises a primary feeding pipe (1); the left side and the right side of the bottom of the primary feeding pipe (1) are connected with a first shunt pipe (2) and a second shunt pipe (3), the bottoms of the first shunt pipe (2) and the second shunt pipe (3) are respectively communicated with a first screen cylinder (4) and a second screen cylinder (5), a first screen material cavity (6) and a second screen material cavity (7) are respectively arranged inside the first screen cylinder (4) and the second screen cylinder (5), the first screen material cavity (6) is arranged at the top end of the second screen material cavity (7), one sides of the bottoms of the two first screen material cavities (6) are respectively communicated with primary discharging pipes (9) of an inclined structure, the two primary discharging pipes (9) are arranged in bilateral symmetry, and the bottom ends of the primary discharging pipes (9) are communicated with a primary secondary screen cylinder (10);
the bottom ends of the two second material sieving cavities (7) are communicated with a secondary material feeding pipe (11), the bottom ends of the two secondary material feeding pipes (11) are communicated with a secondary sieving drum (12) through the secondary material feeding pipes (11), and the two secondary material feeding pipes (11) are arranged in a bilateral symmetry manner; a third screening cavity (13) and a fourth screening cavity (14) are arranged in the secondary screening drum (12) from top to bottom; one side of the bottom of the third screening cavity (13) is communicated with a secondary discharging pipe (16), and the bottom end of the secondary discharging pipe (16) is communicated with a secondary storage box (17); the bottom of the fourth screening cavity (14) is communicated with a third-level discharging pipe (18), and the third-level discharging pipe (18) is communicated with a third-level storage box (19).
2. The device for preparing the slow-release nano-drug for inhibiting the recurrence and the metastasis of tumor according to claim 1, wherein: the first shunt pipe (2) and the second shunt pipe (3) are arranged on the left side and the right side of the first-stage feeding pipe (1) in a bilateral symmetry inclined mode.
3. The device for preparing the slow-release nano-drug for inhibiting the recurrence and the metastasis of tumor according to claim 1, wherein: the first sieve material chamber (6) and the second sieve material chamber (7) are separated by a first-stage sieve membrane (8) with an inclined structure, and the first sieve drum (4) and the first-stage sieve membrane (8) inside the second sieve drum (5) are arranged in a bilateral symmetry manner.
4. The device for preparing the slow-release nano-drug for inhibiting the recurrence and the metastasis of tumor according to claim 1, wherein: the third material sieving cavity (13) and the fourth material sieving cavity (14) are separated by a second-stage sieving film (15) of an inclined structure, and the second-stage sieving films (15) inside the two second-stage sieving cylinders (12) are arranged in a bilateral symmetry mode.
5. The device for preparing the slow-release nano-drug for inhibiting the recurrence and the metastasis of tumor according to claim 1, wherein: the inside of one-level secondary sieve feed cylinder (10) also installs one-level sieve membrane (8) of slope structure, and one-level sieve membrane (8) are from last to cutting apart into one-level ejection of compact chamber (20) and second grade ejection of compact chamber (21) with one-level secondary sieve feed cylinder (10).
6. The device for preparing the slow-release nano-drug for inhibiting the tumor recurrence and metastasis as claimed in claim 5, wherein: a primary material pipe (22) is arranged on one side of the bottom of the primary discharging cavity (20), and the bottom end of the primary material pipe (22) is communicated with a primary material storage box (23); the bottom of the secondary discharging cavity (21) is communicated with the top end of the secondary screen drum (12) through a secondary feeding pipe (24).
7. The device for preparing the slow-release nano-drug for inhibiting the recurrence and the metastasis of tumor according to claim 1, wherein: fixed pillar (25) are all installed to the bottom of a first sieve section of thick bamboo (4) and a second sieve section of thick bamboo (5), are connected with horizontal strut (26) between fixed pillar (25) and a second grade sieve section of thick bamboo (12), and unable adjustment base (27) are installed to the bottom of fixed pillar (25).
8. The device for preparing the slow-release nano-drug for inhibiting the recurrence and the metastasis of tumor according to claim 1, wherein: and the first screen cylinder (4), the second screen cylinder (5), the second screen cylinder (12) and the first-stage secondary screen cylinder (10) are all provided with a vibration motor (28).
9. The device for preparing the slow-release nano-drug for inhibiting the recurrence and the metastasis of tumor according to claim 1, wherein: the first-stage sieve membrane (8) and the second-stage sieve membrane (15) are both provided with nanometer sieve pores, and the pore size of the nanometer sieve pores on the first-stage sieve membrane (8) is larger than that of the nanometer sieve pores on the second-stage sieve membrane (15).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110017774.5A CN112845046A (en) | 2021-01-07 | 2021-01-07 | Preparation device of slow-release nano-drug for inhibiting tumor recurrence and metastasis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110017774.5A CN112845046A (en) | 2021-01-07 | 2021-01-07 | Preparation device of slow-release nano-drug for inhibiting tumor recurrence and metastasis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112845046A true CN112845046A (en) | 2021-05-28 |
Family
ID=76004745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110017774.5A Pending CN112845046A (en) | 2021-01-07 | 2021-01-07 | Preparation device of slow-release nano-drug for inhibiting tumor recurrence and metastasis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112845046A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6032803A (en) * | 1997-09-11 | 2000-03-07 | Waescle Gmbh | Bulk material separator |
| CN107744852A (en) * | 2017-11-14 | 2018-03-02 | 成都华西天然药物有限公司 | A kind of medicine crushing and screening device |
| CN207288078U (en) * | 2017-09-29 | 2018-05-01 | 黑龙江省镈浩石墨有限责任公司 | A kind of spherical graphite classifying equipoment |
| CN108217238A (en) * | 2017-12-26 | 2018-06-29 | 马嘉昌 | A kind of silicon-carbide particle screening plant |
| CN207929546U (en) * | 2018-01-04 | 2018-10-02 | 山东建邦胶体材料有限公司 | A kind of ultrasonic activation screening plant of silver powder |
| CN208555019U (en) * | 2018-05-10 | 2019-03-01 | 安徽圣鹰药业有限公司 | A kind of efficient sieving equipment of oyster shell calcium particle processing |
| KR20190030040A (en) * | 2017-09-13 | 2019-03-21 | 피그넷엔에스(주) | Separation device for harmful substances in corn |
| CN209141197U (en) * | 2018-09-21 | 2019-07-23 | 成都锐起环保科技有限公司 | A kind of screening plant of waste plastic |
-
2021
- 2021-01-07 CN CN202110017774.5A patent/CN112845046A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6032803A (en) * | 1997-09-11 | 2000-03-07 | Waescle Gmbh | Bulk material separator |
| KR20190030040A (en) * | 2017-09-13 | 2019-03-21 | 피그넷엔에스(주) | Separation device for harmful substances in corn |
| CN207288078U (en) * | 2017-09-29 | 2018-05-01 | 黑龙江省镈浩石墨有限责任公司 | A kind of spherical graphite classifying equipoment |
| CN107744852A (en) * | 2017-11-14 | 2018-03-02 | 成都华西天然药物有限公司 | A kind of medicine crushing and screening device |
| CN108217238A (en) * | 2017-12-26 | 2018-06-29 | 马嘉昌 | A kind of silicon-carbide particle screening plant |
| CN207929546U (en) * | 2018-01-04 | 2018-10-02 | 山东建邦胶体材料有限公司 | A kind of ultrasonic activation screening plant of silver powder |
| CN208555019U (en) * | 2018-05-10 | 2019-03-01 | 安徽圣鹰药业有限公司 | A kind of efficient sieving equipment of oyster shell calcium particle processing |
| CN209141197U (en) * | 2018-09-21 | 2019-07-23 | 成都锐起环保科技有限公司 | A kind of screening plant of waste plastic |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9994488B2 (en) | Ultrafine continuous fibrous ceramic filter and method of manufacturing same | |
| CN1077814C (en) | Device for manufacture of composite filtering material and method of its manufacture | |
| CN106310782B (en) | Nanofiber filtering membrane, nanofiber composite filtering membrane and preparation method thereof | |
| JP2003501237A (en) | Filtration material and its manufacturing apparatus and manufacturing method | |
| US20210154606A1 (en) | Efficient low-resistance micro-nano-fiber microscopic gradient structure filtration material, and preparation method therefor | |
| CN104010990B (en) | The compact substance material and the utilization thereof that comprise carbon nanohorn | |
| KR20190050109A (en) | Porous metal organic framework with fibrous structure and method for preparing the same | |
| CN105489916B (en) | A kind of lithium ion battery polymer porous membrane and its preparation method and application | |
| CN1248764C (en) | Thickener for forming thick film and manufacturing method and filtering equipment | |
| CN108905968A (en) | A kind of preparation method and water purification catridge of graphene oxide composite filter element material | |
| CN112845046A (en) | Preparation device of slow-release nano-drug for inhibiting tumor recurrence and metastasis | |
| EP1369157B1 (en) | High rate filter and high rate filtration method using the filter | |
| CN110395978A (en) | A method of filtering molding machine and preparation ITO planar targets | |
| JPH09180730A (en) | Electrode for solid high molecular fuel cell and manufacture thereof | |
| KR20210050993A (en) | Method and apparatus for preparing nanofibers | |
| EP3736041A1 (en) | Porous molding | |
| Yao et al. | Self-assembly of rare-earth Anderson polyoxometalates on the surface of imide polymeric hollow fiber membranes potentially for organic pollutant degradation | |
| CN106466493A (en) | A kind of multilevel hole material | |
| CN111732754B (en) | Three-dimensional scaffold with multistage holes, three-dimensional functional scaffold and preparation method thereof | |
| CN219401133U (en) | Silicon particle end recovery device | |
| CN112316918A (en) | Electrostatic spinning metal chelating affinity adsorption film and preparation method and application thereof | |
| CN111905574A (en) | MXene attapulgite composite film and preparation method thereof | |
| CN211963748U (en) | Fine filtering water treatment device | |
| CN213192773U (en) | Nano intermediate film coating filter | |
| CN110184676B (en) | Emulsion composition, polystyrene nanofiber product, preparation method and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20210528 |