CN112844223B

CN112844223B - Wet granulator for powder pharmacy

Info

Publication number: CN112844223B
Application number: CN202110066233.1A
Authority: CN
Inventors: 李华燕
Original assignee: Beijing Baiwei Innovation Technology Co ltd
Current assignee: Beijing Baiwei Innovation Technology Co ltd
Priority date: 2021-01-19
Filing date: 2021-01-19
Publication date: 2022-10-21
Anticipated expiration: 2041-01-19
Also published as: CN112844223A

Abstract

The invention relates to the technical field of pharmacy, and discloses a wet granulator for powder pharmacy, which comprises an inner cylinder, wherein a top cover is arranged at the top of the inner cylinder, a stirring paddle and a cutting knife are respectively arranged at the bottom and the side wall of the inner cylinder, an outer cylinder is arranged at the periphery of the inner cylinder, a material storage cavity is formed between the inner cylinder and the outer cylinder, an air inlet channel is arranged at the edge of the bottom of the inner cylinder, lower filter cloth is arranged above the air inlet channel, the air inlet channel is communicated with an air pipe, and an air guide channel is arranged on the inner wall of the inner cylinder. According to the invention, the air inlet channel is arranged at the edge of the inner cylinder and is matched with the air guide channel to guide the air to flow, so that a layer of air curtain is formed at the inner wall of the inner cylinder by the air, the material is separated from the inner wall of the inner cylinder, the contact between the inner wall of the inner cylinder and the material can be reduced, the material is effectively prevented from being attached to the inner wall of the inner cylinder, and the air flow exerts an upward acting force on the material, so that the material is favorably moved upwards and overturned, and the uniformity of material mixing is promoted.

Description

Wet granulator for powder pharmacy

Technical Field

The invention relates to the technical field of pharmacy, in particular to a wet granulator for powder pharmacy.

Background

In the wet granulation equipment, the granulation principle of a high-speed mixing granulator is as follows: the two procedures of mixing and granulating are completed in the same container, downward rotation type stirring is adopted, and a stirring paddle is arranged at the bottom of the pan and forms a gap with the bottom of the pan. The stirring blade surface can ensure that the materials are collided and dispersed into a semi-flowing rolling state and achieve full mixing. With the injection of the binder, the powder is gradually moistened, and the shape of the material is changed. The rotation of the chopping knife on the horizontal shaft of the pot wall and the stirring paddle generates vortex, so that the materials are fully mixed, rolled and collided, and the chopping knife in the area where the materials are required to be turned can fully crush the bulk materials into particles. Meanwhile, the materials are extruded, collided, rubbed, sheared and kneaded among particles in three-dimensional motion, so that the particles are rubbed more uniformly and finely, and finally stable spherical particles are formed, thereby forming a damp and uniform soft material.

The mode that present wet granulation adopted regularly pelletizes, set for the pelletization time promptly, open the exit baffle again after the pelletization is accomplished and carry out all materials, consequently can cause partly first fashioned material because can't carry out and constantly be cut, lead to the granule less or directly smash, then fashioned granule volume is then great, consequently can cause the granule size inhomogeneous.

In addition, after the wet granulator is added with the adhesive, the viscous materials are easily adhered to the inner wall of the charging barrel, and the viscosity of the materials and the charging barrel is increased due to the temperature rise because the materials generate heat due to friction in the granulating process, so that the difficulty in cleaning the charging barrel is increased.

Disclosure of Invention

Aiming at the defects of the existing wet granulator in the use process in the background technology, the invention provides the wet granulator for powder pharmacy, which has the advantages of uniform granulation and no material sticking to the wall, and solves the problems that the granules are excessively cut and the material is stuck to the inner wall of a charging barrel in the background technology.

The invention provides the following technical scheme: the utility model provides a wet granulator for powder pharmacy, includes the inner tube, the top of inner tube is equipped with the top cap, stirring rake and cutting knife are installed respectively to the bottom and the lateral wall of inner tube, the periphery of inner tube is equipped with the urceolus, form between inner tube and the urceolus and deposit the material chamber, the intake duct has been seted up at the edge of inner tube bottom, the top of intake duct is equipped with down the filter cloth, the intake duct intercommunication has the trachea, the air guide way has been seted up to the inner wall of inner tube, the venthole has been seted up to the bottom surface of top cap, be equipped with the last filter cloth that is located the venthole below on the outer wall of top cap.

Preferably, the air inlet duct and the air guide duct are inclined in the same direction, and the inclined directions of the air inlet duct and the air guide duct are consistent with the rotating directions of the stirring paddle and the cutting knife.

Preferably, the outer wall of the top cover is provided with springs, one ends, far away from the top cover, of the springs are connected with the upper filter cloth, the springs are evenly distributed along the outer wall of the top cover, the lengths of the springs are the same, and the elastic coefficients of the springs are increased progressively.

Preferably, the inner cavity of the top cover is hollow, the outlet end of the top cover is connected with an air pump, the outlet end of the air pump is connected with an ion fan, and the outlet end of the ion fan is communicated with the air pipe.

Preferably, the sieve plate is connected with the middle upper side of the inner cylinder inner wall, the sieve mesh is arranged on the sieve plate, the sieve mesh is provided with the sieve material component, and the sieve plate is provided with a groove which is the same as the air entraining channel and is arranged on the extension line of the air entraining channel.

Preferably, the sieve material subassembly includes baffle and reed, the baffle is located the inside of sieve mesh and flushes mutually with the surface of sieve, the baffle is located the sieve mesh and offsets with the reed, the reed can be dismantled.

The invention has the following beneficial effects:

1. according to the invention, the air inlet channel is arranged at the edge of the inner cylinder and is matched with the air guide channel to guide the air to flow, so that a layer of air curtain is formed at the inner wall of the inner cylinder by the air, the material is separated from the inner wall of the inner cylinder, the contact between the inner wall of the inner cylinder and the material can be reduced, the material is effectively prevented from being attached to the inner wall of the inner cylinder, and the air flow exerts an upward acting force on the material, so that the material is favorably moved upwards and overturned, and the uniformity of material mixing is promoted.

2. According to the invention, the sieve plate is arranged above the inner cylinder, and the sieve component is matched to screen the compactness and the size of particles, so that the particles meeting the requirements are screened out, the condition that the particles are smaller or chopped due to the fact that the particles are continuously cut in the inner cavity of the inner cylinder is avoided, and the quality and the size uniformity of the particles are improved.

Drawings

FIG. 1 is a schematic view of the structure of the present invention;

FIG. 2 is an enlarged view of a portion A of FIG. 1;

FIG. 3 is a schematic top view of a portion of the inner barrel of the present invention;

fig. 4 is a bottom view of the top cap of the present invention.

In the figure: 1. an inner barrel; 101. an air inlet channel; 2. an outer cylinder; 3. a top cover; 301. an air outlet; 4. an air tube; 5. lower filter cloth; 6. an air guide passage; 7. filtering cloth; 8. a spring; 9. a sieve plate; 901. screening holes; 10. a storage cavity; 11. a screen assembly; 1101. a baffle plate; 1102. a reed; 12. an ion fan.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1-4, a wet granulator for powder pharmacy comprises an inner cylinder 1, wherein a top cover 3 is arranged at the top of the inner cylinder 1, a stirring paddle and a cutter are respectively arranged at the bottom and the side wall of the inner cylinder 1, an outer cylinder 2 is arranged at the periphery of the inner cylinder 1, a material storage cavity 10 is formed between the inner cylinder 1 and the outer cylinder 2, an air inlet 101 is formed at the edge of the bottom of the inner cylinder 1, the air inlet 101 is uniformly formed along the edge of an air guide channel 6, lower filter cloth 5 is arranged above the air inlet 101, the lower filter cloth 5 plays a role in filtering air entering the inner cavity of the inner cylinder 1 from the air inlet 101, and simultaneously prevents the material in the inner cylinder 1 from permeating into the air inlet 101 to cause blockage of the air inlet 101, the air inlet 101 is communicated with an air pipe 4, the inner wall of the inner cylinder 1 is provided with an air guide channel 6, the air guide channel 6 plays a role in guiding air flow, the air flow upwards flows along the inner wall of the inner cylinder 1, an air curtain is formed between the material and the inner wall of the inner cylinder 1, and the contact between the material and the inner wall of the inner cylinder 1 can be reduced, so as to reduce the material sticking to the inner wall of the inner cylinder 1; intake duct 101 and bleed air way 6 homodromous slope, the incline direction of intake duct 101 and bleed air way 6 is unanimous with the direction of rotation of stirring rake and cutting knife, in order to avoid carrying the opposite direction that causes the material impact to fly off to the air current in the inner tube 1 inner chamber and material rotation from trachea 4, in the design, the direction of intake duct 101 and bleed air way 6 is fixed, consequently, need make its unanimous with the incline direction of intake duct 101 and bleed air way 6 through the direction of rotation of adjustment stirring rake and cutting knife, and also exert ascending effort to the material along the ascending air current of bleed air way 6, drive the material and upwards overturn, effectively promote the material misce bene.

The bottom surface of the top cover 3 is provided with an air outlet hole 301, the outer wall of the top cover 3 is provided with an upper filter cloth 7 positioned below the air outlet hole 301, and the upper filter cloth 7 is used for blocking materials and preventing the materials from escaping; be equipped with spring 8 on top cap 3's the outer wall, the one end that top cap 3 was kept away from to spring 8 is connected with last filter cloth 7, spring 8 evenly arranges along top cap 3's outer wall, spring 8's the same and the elastic coefficient of length increases progressively, when the air current contacted last filter cloth 7, because the velocity of flow of gas is roughly the same, kinetic energy is roughly the same, and spring 8's elastic coefficient is different, then spring 8 that elastic coefficient is big is extruded by wind-force for a short time by wind-force extrusion's degree big, thereby spring 8 has formed the state of high difference at a plurality of springs 8, and spring 8 links to each other with last filter cloth 7, consequently, go up filter cloth 7's different position sunken difference, and the time point that spring 8 extends is different, make go up filter cloth 7 and form the condition of a vibration, be favorable to shaking off the material that shelters from on the last filter cloth 7, reduce the loss of material.

The inner chamber cavity of top cap 3, the exit end of top cap 3 is connected with the air pump, the exit end of air pump is connected with ion fan 12, the exit end of ion fan 12 is linked together with trachea 4, because the material in the inner chamber of inner tube 1 is in the process of constantly striking, rubbing with the inner wall of inner tube 1, produce static easily, and the gas that gets into in the inner chamber of inner tube 1 through trachea 4 is the gas that has an electric charge by ion fan 12 output, can effectively neutralize the static in the inner tube 1.

A sieve plate 9 is connected to the upper middle of the inner wall of the inner cylinder 1, a sieve hole 901 is formed in the sieve plate 9, a sieve component 11 is arranged at the position of the sieve hole 901, and a groove which is the same as the air guide channel 6 and is arranged on the extension line of the air guide channel 6 is formed in the sieve plate 9; the screening component 11 comprises a baffle 1101 and a reed 1102, the baffle 1101 is positioned inside the sieve hole 901 and is flush with the surface of the screen plate 9, the baffle 1101 is connected with one point on the inner wall of the sieve hole 901, the baffle 1101 can rotate around the point to achieve the purposes of shielding the sieve hole 901 and opening the sieve hole 901, the baffle 1101 is positioned in the sieve hole 901 and is abutted against the reed 1102, and the reed 1102 is detachable; when the material is powdery, the particles are small, the weight is light, the centrifugal force of the material under the rotation of the stirring paddle is not enough to overcome the abutting pressure of the reed 1102, so that the baffle 1101 cannot be opened and the material enters the material storage cavity 10 from the sieve plate 9, when the material is granular, the size and the mass of the particle are increased, the centrifugal force of the particle is also increased, the pressure of the reed 1102 can be overcome in the rotating process to open the baffle 1101 and the material enters the material storage cavity 10 from the sieve plate 9, and the material which is made into the particles can be continuously screened out by the material in the inner cylinder 1 in the operation process in the unloading mode, so that the material particles are prevented from being cut too small; since the sieve plate 9 is arranged above and in the middle of the inner cylinder 1, the situation that the baffle 1101 is opened due to large amount of medicine powder and large extrusion force can be prevented, and therefore medicine powder which is not granulated can be prevented from entering the storage cavity 10 through the sieve holes 901; meanwhile, the reduction of the material amount in the inner cavity of the inner barrel 1 is beneficial to promoting the uniform mixing of the residual materials; since the reed 1102 is detachable, the supporting force of the reed 1102 on the baffle 1101 can be changed by replacing different reeds 1102, so that the tightness of the particles can be checked, and when the particles are not tight enough although the particles are large in size, the particles are easy to break when the particles impact on the baffle 1101 and cannot enter the storage cavity 10 through the sieve holes 901.

In addition, in the whole granulating process, the material storage cavity 10 is not contacted with the outside, and the air entering the inner cavity of the inner barrel 1 through the air pipe 4 is sterilized and disinfected, so that the safety of the medicinal powder can be ensured without pollution.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The utility model provides a wet granulator for powder pharmacy, includes inner tube (1), the top of inner tube (1) is equipped with top cap (3), stirring rake and cutting knife, its characterized in that are installed respectively to the bottom and the lateral wall of inner tube (1): an outer barrel (2) is arranged at the periphery of the inner barrel (1), a material storage cavity (10) is formed between the inner barrel (1) and the outer barrel (2), an air inlet channel (101) is formed in the edge of the bottom of the inner barrel (1), lower filter cloth (5) is arranged above the air inlet channel (101), the air inlet channel (101) is communicated with an air pipe (4), an air guide channel (6) is formed in the inner wall of the inner barrel (1), an air outlet hole (301) is formed in the bottom surface of the top cover (3), and upper filter cloth (7) located below the air outlet hole (301) is arranged on the outer wall of the top cover (3);

a sieve plate (9) is connected to the upper middle of the inner wall of the inner barrel (1), sieve holes (901) are formed in the sieve plate (9), a sieve material assembly (11) is arranged at the positions of the sieve holes (901), and a groove which is the same as the air guide channel (6) and is arranged on the extension line of the air guide channel (6) is formed in the sieve plate (9);

the screen assembly (11) comprises a baffle (1101) and reeds (1102), the baffle (1101) is located inside the screen holes (901) and is flush with the surface of the screen plate (9), the baffle (1101) is located inside the screen holes (901) and is abutted to the reeds (1102), and the reeds (1102) can be detached.

2. The wet granulator for powder pharmaceutical use according to claim 1, characterized in that: intake duct (101) and bleed way (6) homodromous slope, the incline direction of intake duct (101) and bleed way (6) is unanimous with the direction of rotation of stirring rake and cutting knife.

3. The wet granulator according to claim 1, characterized in that: be equipped with spring (8) on the outer wall of top cap (3), the one end that top cap (3) were kept away from in spring (8) is connected with last filter cloth (7), spring (8) are evenly arranged along the outer wall of top cap (3), the same and the elastic coefficient of length of spring (8) increases progressively.

4. The wet granulator according to claim 1, characterized in that: the inner cavity of the top cover (3) is hollow, the outlet end of the top cover (3) is connected with an air pump, the outlet end of the air pump is connected with an ion fan (12), and the outlet end of the ion fan (12) is communicated with the air pipe (4).