CN112843185A - Diabetes adjuvant therapy paste based on nano extraction and preparation method thereof - Google Patents
Diabetes adjuvant therapy paste based on nano extraction and preparation method thereof Download PDFInfo
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- CN112843185A CN112843185A CN202110195278.9A CN202110195278A CN112843185A CN 112843185 A CN112843185 A CN 112843185A CN 202110195278 A CN202110195278 A CN 202110195278A CN 112843185 A CN112843185 A CN 112843185A
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- adjuvant therapy
- diabetes
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Abstract
The invention discloses a diabetes adjuvant therapy paste based on nano extraction and a preparation method thereof, wherein the paste comprises the following raw materials, by mass, 50-96 parts of bitter gourd, 39-71 parts of evening primrose, 34-57 parts of phellinus igniarius, 10-32 parts of cinnamon, 12-30 parts of astragalus membranaceus, 4-15 parts of rhizoma anemarrhenae, 10-22 parts of radix trichosanthis, 17-39 parts of corn stigma, 5-10 parts of cortex lycii radicis, 3-9 parts of saponin and 4-26 parts of gynostemma pentaphyllum. The diabetes adjuvant therapy paste based on nano extraction improves the drug effect of the medicine through the nano extraction technology, and can be used for adjuvant therapy of diabetes through an internal disease external therapy mode.
Description
The technical field is as follows:
the invention relates to the field of medicines, in particular to a diabetes adjuvant therapy paste based on nano extraction and a preparation method thereof.
Background art:
diabetes as a modern epidemic disease has more and more seriously affected the normal life of people, even has the threats of blindness, disability and death in serious cases, has developed into a global disease, and particularly has the morbidity far higher than that of other developed countries in China. In recent years, with the continuous improvement of the living standard of Chinese people, excessive and complicated eating habits and less exercise amount aggravate the body metabolism of people, the intake energy is far higher than the consumption capacity, so that the 'rich and precious diseases' become more and more popular in China, the patients are afflicted with physical and mental diseases due to complicated and various complications, the treatment cost is high, and the economic burden of the patients is increased. Diabetes mellitus is a metabolic disease characterized by hyperglycemia, which is caused by defects in insulin secretion or dysfunction of insulin, or both, leading to endocrine disorders, dysoxyhemoglobin metabolism, and a series of complications. Diabetes can be divided into type 1 diabetes and type 2 diabetes and various acute and chronic complications, the clinical manifestations are more than three and less than one, i.e. polydipsia, polyphagia, diuresis and weight loss, type 2 diabetes is mostly fatigue and weakness, obesity and other symptoms, and the diabetic complications are various and complicated, such as diabetic nephropathy, eye diseases, hyperlipidemia, hypertension, alopecia, skin pruritus, diabetic nervous system complications and the like. Acute ketoacidosis, hypertonic coma, lactic acidosis, coronary heart disease, uremia, cerebral hemorrhage and the like can be caused seriously, and the health and the life of people can be endangered at any time. In the treatment process of diabetes, patients need to be matched with reasonable diet and properly take certain amount of exercise to reduce the recurrence of complications, most of the existing medicines for treating the diabetes complications are mainly used for controlling symptoms, and although the existing medicines have curative effects, the complications are easy to recur, so that the research of a medicine for fundamentally conditioning physique so as to realize the cure of the complications is the current research direction of the people.
Aiming at the defects in the prior art, the traditional Chinese medicine therapy has unique curative effect in the treatment of diabetic complications, the traditional Chinese medicine considers that diabetes belongs to the category of diabetes and diabetes, the pathology is originated from three organs of lung, spleen and kidney, yin deficiency is the essence of diabetes, spleen deficiency is the root of diabetes which cannot be cured for a long time, blood stasis is the key for causing the diabetic complications, and various complications are caused by yin and body fluid deficiency, meridian obstruction, qi stagnation and blood stasis and metabolic disorder, but the prior art still lacks corresponding in-vitro adjuvant therapy medicines.
The invention content is as follows:
the technical problem to be solved by the invention is to provide the diabetes adjuvant therapy paste based on the nano extraction, the efficacy of the medicine is improved by the nano extraction technology, and the diabetes can be treated in an adjuvant mode by an internal disease external treatment mode.
The invention provides a diabetes adjuvant therapy paste based on nano extraction, which comprises the following raw materials, by mass, 50-96 parts of bitter gourd, 39-71 parts of evening primrose, 34-57 parts of phellinus igniarius, 10-32 parts of cinnamon, 12-30 parts of astragalus membranaceus, 4-15 parts of rhizoma anemarrhenae, 10-22 parts of radix trichosanthis, 17-39 parts of corn stigma, 5-10 parts of cortex lycii radicis, 3-9 parts of saponin, 4-26 parts of gynostemma pentaphylla, 5-23 parts of rhizoma polygonati, 3-10 parts of salvia miltiorrhiza, 2-7 parts of ganoderma lucidum, 1-3 parts of ginseng and 250 parts of solvent 150 organic solvents.
Preferably, the composition also comprises 7-15 parts of guava leaves and 1-2 parts of leech.
Preferably, the salvia miltiorrhiza and the ginseng can be replaced by dendrobium officinale, and the mass fraction of the dendrobium officinale is 3-9 parts.
Preferably, the traditional Chinese medicine composition comprises, by mass, 60 parts of bitter gourd, 45 parts of evening primrose, 39 parts of phellinus igniarius, 16 parts of cinnamon, 13 parts of astragalus membranaceus, 10 parts of rhizoma anemarrhenae, 13 parts of trichosanthes root, 20 parts of corn stigma, 7 parts of cortex lycii radicis, 5 parts of saponin, 6 parts of gynostemma pentaphylla, 7 parts of rhizoma polygonati, 5 parts of salvia miltiorrhiza, 3 parts of ganoderma lucidum, 1 part of ginseng and 180 parts of a solvent.
The invention also provides a preparation method of the diabetes adjuvant therapy paste based on nano extraction, which comprises the following steps,
preparing gas and a solvent into fluid containing nano bubbles by a nano bubble generating device;
crushing the raw materials by using a high-pressure homogenizer, and adding the crushed raw materials and the fluid containing nano bubbles into a reaction container, wherein the raw materials comprise 50-96 parts of bitter gourd, 39-71 parts of evening primrose, 34-57 parts of phellinus igniarius, 10-32 parts of cinnamon, 12-30 parts of astragalus membranaceus, 4-15 parts of rhizoma anemarrhenae, 10-22 parts of radix trichosanthis, 17-39 parts of corn stigma, 5-10 parts of cortex lycii radicis, 3-9 parts of saponin, 4-26 parts of gynostemma pentaphyllum, 5-23 parts of rhizoma polygonati, 3-10 parts of salvia miltiorrhiza, 2-7 parts of ganoderma lucidum and 1-3 parts of ginseng;
mixing the raw materials by using a fluid containing nano bubbles, wherein the reaction temperature is 25-50 ℃ during mixing;
after uniform mixing, performing ultrasonic energy treatment on the reaction vessel by using an ultrasonic energy generator, wherein the ultrasonic energy explodes nanobubbles, increases collision between the fluid containing the nanobubbles and the raw material and improves the extraction effect;
and step five, adding 3-6% by mass of a thickening agent (sodium polyacrylate) and 0.1-1% by mass of an antioxidant (tartaric acid) into the extract liquor obtained in the step four, stirring into gel by using a double-planet stirrer, and preparing into paste.
Preferably, the gas is nitrogen.
Preferably, the solvent is purified water and any one or combination of glycerol, polyethylene glycol and sorbitol.
Preferably, the ultrasonic energy is at least 12W/cm2。
Further, the concentration of nanobubbles should not be less than 2X 107individual/mL bubbles, nanobubbles having an average bubble diameter of 70nm to about 90 nm.
Compared with the prior art, the invention has the following advantages after adopting the scheme: the ointment is prepared by reasonably matching various traditional Chinese medicinal materials, and the effective components are extracted by using a nano extraction technology, so that the drug effect is improved, the diabetes is treated in an auxiliary way by externally treating the internal diseases, the use method is simple, the curative effect is exact, the treatment course is short, and no toxic or side effect exists.
The specific implementation mode is as follows:
the invention is further illustrated with respect to specific embodiments below:
example 1
An auxiliary treatment paste for diabetes based on nano extraction comprises, by mass, 60 parts of balsam pear, 45 parts of evening primrose, 39 parts of phellinus igniarius, 16 parts of cinnamon, 13 parts of astragalus membranaceus, 10 parts of rhizoma anemarrhenae, 13 parts of trichosanthes kirilowii, 20 parts of corn stigma, 7 parts of cortex lycii radicis, 5 parts of saponin, 6 parts of gynostemma pentaphylla, 7 parts of rhizoma polygonati, 5 parts of salvia miltiorrhiza, 3 parts of lucid ganoderma, 1 part of ginseng and 180 parts of solvent, wherein the solvent is a mixture of purified water, glycerol and polyethylene glycol, and the glycerol and the polyethylene glycol act on the paste as a humectant, and the content of the glycerol and the polyethylene glycol accounts for 28% of the mass of the water.
Example 2
Different from the embodiment 1, the me food further comprises the following components, by mass, 7-15 parts of guava leaves and 1-2 parts of leeches. The adaptability is better by adjusting the components.
Example 3
On the basis of the embodiment 2, the salvia miltiorrhiza and the ginseng are replaced by the dendrobium officinale, the mass fraction of the dendrobium officinale is 5 parts, and the dendrobium officinale can be used as a replacement scheme for patients who are easy to get inflamed, so that the medicine property is mild.
The preparation of example 1 is further illustrated below, comprising the following steps,
preparing gas and a solvent into fluid containing nano bubbles by a nano bubble generating device; wherein, the gas is nitrogen, and the solvent is a mixture of purified water, glycerol and polyethylene glycol;
step two, crushing the raw materials by using a high-pressure homogenizer, and adding the crushed raw materials and the fluid containing nano bubbles into a reaction container, wherein 60 parts of balsam pear, 45 parts of evening primrose, 39 parts of phellinus igniarius, 16 parts of cinnamon, 13 parts of astragalus membranaceus, 10 parts of rhizoma anemarrhenae, 13 parts of radix trichosanthis, 20 parts of corn stigma, 7 parts of cortex lycii radicis, 5 parts of saponin, 6 parts of gynostemma pentaphylla, 7 parts of rhizoma polygonati, 5 parts of salvia miltiorrhiza, 3 parts of ganoderma lucidum and 1 part of ginseng;
mixing the raw materials by using a fluid containing nano bubbles, wherein the reaction temperature is 43 ℃ during mixing;
after uniform mixing, performing ultrasonic energy treatment on the reaction vessel by using an ultrasonic energy generator, wherein the ultrasonic energy explodes nanobubbles, increases collision between the fluid containing the nanobubbles and the raw material and improves the extraction effect; ultrasonic energy of 14W/cm2The concentration of the nano bubbles is 2.5 multiplied by 107one/mL bubble, nanobubbles having an average bubble diameter of 75 m;
step five, adding 3 percent by mass of sodium polyacrylate and 0.3 percent by mass of tartaric acid into the extract liquor obtained in the step four, and stirring the mixture into gel by using a double-planet stirrer to obtain paste.
When in use, the paste prepared above is coated on a coating machine into a patch with thickness of 400 μm and 6 × 12 cm. The use method comprises the following steps: the patch is baked with slow fire or heated to 50 deg.C before being applied to navel, and is applied to navel immediately, and applied at night, and taken half a month to 1 month continuously (poor constitution and good quality for 1 month) in the morning as a course of treatment, and meanwhile, radix Codonopsis, Trichosanthis radix, etc. are used for soaking in boiling water to replace tea for drinking, or applied to other parts of body such as back and chest, etc.
The invention prepares the ointment by reasonably matching a plurality of Chinese medicinal materials, extracts effective components by utilizing a nano extraction technology, improves the drug effect, carries out auxiliary treatment on diabetes by externally treating internal diseases, and has the advantages of simple usage, exact curative effect, short treatment course and no toxic or side effect.
The foregoing is illustrative of the preferred embodiments of the present invention only and is not to be construed as limiting the claims. All the equivalent structures or equivalent process changes made by the description of the invention are included in the scope of the patent protection of the invention.
Claims (9)
1. A diabetes adjuvant therapy paste based on nano extraction is characterized in that: the traditional Chinese medicine composition comprises, by mass, 50-96 parts of bitter gourd, 39-71 parts of evening primrose, 34-57 parts of phellinus igniarius, 10-32 parts of cinnamon, 12-30 parts of astragalus membranaceus, 4-15 parts of rhizoma anemarrhenae, 10-22 parts of trichosanthes root, 17-39 parts of corn stigma, 5-10 parts of cortex lycii radicis, 3-9 parts of saponin, 4-26 parts of gynostemma pentaphylla, 5-23 parts of rhizoma polygonati, 3-10 parts of salvia miltiorrhiza, 2-7 parts of ganoderma lucidum, 1-3 parts of ginseng and 250 parts of solvent 150-.
2. The diabetes adjuvant therapy paste based on nano extraction as claimed in claim 1, wherein: also comprises 7-15 parts of guava leaves and 1-2 parts of leech.
3. The diabetes adjuvant therapy paste based on nano extraction as claimed in claim 1, wherein: the salvia miltiorrhiza and the ginseng can be replaced by dendrobium officinale, and the mass fraction of the dendrobium officinale is 3-9 parts.
4. The diabetes adjuvant therapy paste based on nano extraction as claimed in claim 1, wherein: the traditional Chinese medicine composition comprises, by mass, 60 parts of bitter gourd, 45 parts of evening primrose, 39 parts of phellinus igniarius, 16 parts of cinnamon, 13 parts of astragalus membranaceus, 10 parts of rhizoma anemarrhenae, 13 parts of radix trichosanthis, 20 parts of corn stigma, 7 parts of cortex lycii radicis, 5 parts of saponin, 6 parts of gynostemma pentaphylla, 7 parts of rhizoma polygonati, 5 parts of salvia miltiorrhiza, 3 parts of ganoderma lucidum, 1 part of ginseng and 180 parts of a solvent.
5. A preparation method of a diabetes adjuvant therapy paste based on nano extraction is characterized in that: comprises the following steps of (a) carrying out,
preparing gas and a solvent into fluid containing nano bubbles by a nano bubble generating device;
crushing the raw materials by using a high-pressure homogenizer, and adding the crushed raw materials and the fluid containing nano bubbles into a reaction container, wherein the raw materials comprise 50-96 parts of bitter gourd, 39-71 parts of evening primrose, 34-57 parts of phellinus igniarius, 10-32 parts of cinnamon, 12-30 parts of astragalus membranaceus, 4-15 parts of rhizoma anemarrhenae, 10-22 parts of radix trichosanthis, 17-39 parts of corn stigma, 5-10 parts of cortex lycii radicis, 3-9 parts of saponin, 4-26 parts of gynostemma pentaphyllum, 5-23 parts of rhizoma polygonati, 3-10 parts of salvia miltiorrhiza, 2-7 parts of ganoderma lucidum and 1-3 parts of ginseng;
mixing the raw materials by using a fluid containing nano bubbles, wherein the reaction temperature is 25-50 ℃ during mixing;
after uniform mixing, performing ultrasonic energy treatment on the reaction vessel by using an ultrasonic energy generator, wherein the ultrasonic energy explodes nanobubbles, increases collision between the fluid containing the nanobubbles and the raw material and improves the extraction effect;
and step five, adding 3-6% of thickening agent and 0.1-1% of antioxidant by mass into the extract liquor obtained in the step four, and stirring into gel by using a double-planet stirrer to prepare paste.
6. The method for preparing the diabetes adjuvant therapy paste based on the nano extraction as claimed in claim 5, is characterized in that: the gas is nitrogen.
7. The method for preparing the diabetes adjuvant therapy paste based on the nano extraction as claimed in claim 5, is characterized in that: the solvent is the combination of purified water and any one or more of glycerol, polyethylene glycol and sorbitol.
8. The method for preparing the diabetes adjuvant therapy paste based on the nano extraction as claimed in claim 5, is characterized in that: ultrasonic energy of at least 12W/cm2。
9. The method for preparing the diabetes adjuvant therapy cream based on the nano extraction as claimed in claim 8, is characterized in that: the concentration of nano bubbles should not be less than 2 × 107individual/mL bubbles, nanobubbles having an average bubble diameter of 70nm to about 90 nm.
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| GB2622125A (en) * | 2021-09-07 | 2024-03-06 | Nihon Kilmar Co Ltd | Topical composition for nanobubble cosmetic |
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