CN112826904A - Medicine for quickly treating hyperplasia of mammary glands - Google Patents
Medicine for quickly treating hyperplasia of mammary glands Download PDFInfo
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Abstract
The invention discloses a medicine for quickly treating hyperplasia of mammary glands, which is prepared by taking hawthorn, angelica dahurica, fingered citron, malt, kelp, tuckahoe, citron, peach kernel, safflower, perilla, kudzu root, orange peel, rose, selfheal, angelica, turmeric, ginseng and liquorice as raw materials according to a certain weight ratio. The medicament has the functions of promoting blood circulation, removing obstruction in channels, soothing liver, relieving depression, regulating qi, reducing swelling, strengthening spleen, regulating menstruation and the like, has good effects on treating symptoms such as hyperplasia of mammary glands, local swelling and pain of breasts, dysphoria, depression, irregular menstruation, emotional dissatisfaction, limb weakness and the like, and has particularly quick response and no toxic or side effect.
Description
Technical Field
The invention relates to a medicament for quickly treating hyperplasia of mammary glands, in particular to a medicament which is prepared from plant Chinese medicaments which are all used as medicaments and foods according to a certain weight ratio and has obvious improvement effect on treating hyperplasia of mammary glands, local swelling and pain of breasts, dysphoria and depression, irregular menstruation, emotional distress, limb weakness and other symptoms.
Background
Mastoplasia (HDBA) is a common disease in women, and its onset features are the general names of diseases in which the abnormal proliferation of fibrous connective tissue and epithelial cells of breast and the degenerative change of mammary duct and lobule into basic pathological changes, also called as mammary dysplasia or hyperplasia.
Hyperplasia of mammary glands is currently the most common non-inflammatory, non-neoplastic disease in women. The incidence rate of the breast cancer is about 40% of women in the childbearing age, and accounts for 75% of all breast diseases. Reports have shown that the incidence rate is more than 90% in women over 30 years of age. Because the population base of China is large, the number of the people with the disease is considerable.
The hyperplasia of mammary glands has long course of disease and easy recurrence, has local lumps and obvious pain and discomfort symptoms, belongs to the lesion of the breast dysplasia, and mainly comprises two types of simple hyperplasia of mammary glands and cystic hyperplasia of mammary glands. In addition to the pain and discomfort symptoms, the part of patients with the disease still has the risk of malignant change, and the physical and psychological health of a plurality of patients is seriously harmed.
In clinical terms, western medicines do not have ideal treatment methods, and some western medicines have large side effects and limit wide clinical application. For example, the selective estrogen receptor modulator tamoxifen can effectively reduce the estrogen level in tissues, has a certain effect on treating hyperplasia of mammary glands, but also destroys the endocrine system of a patient while treating, and causes more serious complications, such as irregular menstruation, dizziness, facial acne and the like.
Although there are many Chinese patent medicines for treating hyperplasia of mammary glands, some medicines have unsatisfactory curative effect, and especially some medicines need to be taken for a long time and have potential safety hazards. At present, the development of a Chinese patent medicine with no toxic or side effect and remarkable treatment effect is urgent for clinical research.
In the aspect of clinical treatment, some scholars deeply explore, and in the aspect of research on action mechanism, clinical experiments and observation are performed in many aspects, so that feasible medication schemes are found, a research basis is laid for effective treatment of traditional Chinese medicine, and meanwhile, the treatment effect is remarkably improved.
A great deal of clinical researches prove that absolute or relative increase of estrogen level and relative low of progestogen level cause the mammary tissue to lose the protective effect of the progestogen, and further cause the estrogen to over-stimulate the mammary gland to cause the disease. From this perspective, the method widens the medication thought for the treatment approach of the traditional Chinese medicine, and can effectively relieve and even eliminate the hyperplasia of mammary glands by regulating the endocrine system and promoting the relative balance of the estrogen and the progestogen.
Several clinical studies have demonstrated that breast proliferative disorders can also be effectively treated by modulating estrogen and progestin receptors. It is believed that estrogen receptor is the medium of hormone to exert biological effect on target organs, and it is believed by some researchers that the abnormal increase of estradiol is mediated by estrogen receptor, so that the synthesis of estrogen receptor progestogen receptor is further increased through the complete estrogen receptor system, and the dependence and sensitivity of estradiol are increased, thereby causing hyperplasia of mammary epithelial cells and activating cell function. Research proves that some traditional Chinese medicines can inhibit hyperplasia of mammary glands of rats, reduce the contents of estrogen receptors and progestogen receptors of mammary gland tissues, promote the sensitivity of mammary glands to estrogen to be reduced, and play an effective treatment role.
However, no specific medicine for regulating endocrine and regulating the whole physical and mental conditions is available in the medicine market. Because the hyperplasia of mammary glands is complicated, the single treatment of the hyperplasia of mammary glands does not consider the cause and the influence on the whole body of the hyperplasia of mammary glands, and is a less scientific, less comprehensive and non-ideal medicament. Aiming at the problem, the inventor of Wangzhi folk Master traditional Chinese medicine doctors conducts multi-aspect, multi-level and multi-discipline discussion, and considers that part of traditional Chinese medicines with dual purposes of medicine and food can be selected to achieve the purpose of effective treatment.
Based on the thought, the traditional Chinese medicine inheritance studio instructor in Tianjin city, which is well-chosen by the master, combines the pharmacological research of traditional Chinese medicines according to the basic principles of syndrome differentiation treatment and holism, and applies the means of combining syndrome differentiation and disease differentiation to obtain success, and invents an efficient prescription for treating the hyperplasia of mammary glands by taking the traditional Chinese medicines with both medicine and food as the formula basis. The generation of the new medicine fills the blank of treating the hyperplasia of mammary glands by using the medicine-food dual-purpose traditional Chinese medicine, realizes the perfect combination of safety and effectiveness, and widens the channel for clinical medicine.
Disclosure of Invention
The medicine for quickly curing hyperplasia of mammary glands with the functions of promoting blood circulation, removing obstruction in the channels, dispersing stagnated liver qi, relieving depression, regulating spleen and regulating menstruation, etc. can quickly relieve the symptoms of hyperplasia of mammary glands and mammary gland local swelling and pain, dysphoria, depression, menoxenia, emotional discomfortable and limb debilitation, etc. and has reliable therapeutic action, quick action and no toxic side effect.
Hyperplasia of mammary glands belongs to the category of nodules of breast in traditional Chinese medicine. The main causes of this disease are related to stagnation of qi due to depression of the liver, dysfunction of the spleen in transportation, accumulation of phlegm and blood stasis. Among them, the most important viscera suffering from hyperplasia of mammary glands is the liver and spleen. The liver stores blood and governs smoothing flow of qi, so it has very important influence on qi and blood. The physiological functions of breast growth, development and milk secretion are closely related to the zang-fu organs, qi and blood, meridians and collaterals. The innate essence of the breast is not physically and pathologically independent, and is affected by the five zang-organs, six fu-organs, qi, blood, body fluids and twelve meridians, wherein the most closely related are the liver, spleen and stomach, and the second is the thoroughfare and conception vessels.
Liver qi stagnation failing to disperse and purge may cause disorder of qi and blood, directly or indirectly affecting breast function, and stagnation of qi and blood may cause diseases in mammary glands. The pressure of contemporary women in learning, working, economy and so on is not inferior to that of men, and is easy to cause depression, which causes stagnation of liver qi and abnormal catharsis, and causes breast diseases. Also before menstruation, qi and blood change, and during the process of uterus overflow and diarrhea, once qi and blood stagnation occurs in breast, symptoms such as obstruction, pain and swelling occur.
Cloud of Danxi Heart method: "Qi and blood are harmonized with each other, and all diseases are not born, so that people always have stagnation and all diseases are born. Physiological qi and blood changes occur in menstrual period of women in the childbearing age, endocrine hormone balance is broken, emotion is easy to melancholy, and the liver catharsis function is abnormal, so that abnormality in aspects of qi and blood, menstrual flow, color, spirit and the like is caused, and diseases such as mammary swelling, pain, mammary hyperplasia aggravation and the like occur. Clinically, the diseases are smooth in qi and blood, pain is relieved and lumps can be eliminated by soothing the liver, regulating qi, promoting blood circulation and removing blood stasis.
The spleen governs transportation and transformation, and generation of qi and blood. The liver and spleen are closely related and mutually take the role of each other. The spleen requires the smoothing flow of the liver, and the liver requires the generation of qi and blood by the spleen for nourishing. When the spleen and stomach are abnormal in ascending, descending, transportation, transformation and absorption functions, the attention should be paid to strengthening the spleen and stomach, and promoting the generation and transformation of qi and blood so as to ensure that the qi and blood are sufficient and the liver stores the blood as usual and to dredge and drain orderly. The symptoms of weakness of limbs, inappetence, lusterless complexion, scanty menstruation and the like of clinical patients are all related to the weakness of spleen qi.
Therefore, the formula for treating the hyperplasia of mammary glands needs to consider soothing liver and regulating qi, and also needs to pay attention to strengthening spleen and stomach, so that the functions of viscera are harmonious, and the hyperplasia of mammary glands can be effectively relieved. In the aspect of traditional Chinese medicine treatment, clinical treatment needs to be carried out according to the disease condition, and the pathogenesis characteristics of the hyperplasia of mammary glands are mainly reflected in the aspects of liver depression, qi stagnation, blood stasis, phlegm dampness and the like, and are related to factors such as liver and spleen disorder and the like. The clinical research of nearly 50 years by the traditional Chinese medicine inheritance studio instructor in Tianjin and the leading traditional Chinese medicine teacher in Wangzhong province considers that the main pathogenesis of the disease is the closest to the liver and spleen, and the key points of the formula are in the aspects of soothing the liver, regulating the flow of qi, strengthening the spleen and stomach, promoting blood circulation, removing blood stasis, dredging collaterals, relieving pain and the like. Clinical studies prove that the idea of the formula is scientific and more effective than a single and direct analgesic effect.
The medicine is realized by the following technical scheme. A medicine and food dual purpose medicine for rapidly treating hyperplasia of mammary glands is characterized in that the medicine and food dual purpose medicine is prepared by the following raw materials in parts by weight by the conventional process of Chinese materia medica pharmaceutics: 10-90 parts of hawthorn, 10-50 parts of angelica dahurica, 10-90 parts of fingered citron, 10-60 parts of malt, 10-60 parts of kelp, 10-90 parts of poria cocos, 10-60 parts of citron, 10-90 parts of peach kernel, 10-45 parts of safflower, 10-90 parts of purple perilla, 10-60 parts of kudzu root, 10-90 parts of orange peel, 10-90 parts of rose, 10-60 parts of selfheal, 10-90 parts of angelica sinensis, 10-90 parts of turmeric, 10-90 parts of ginseng and 10-90 parts of liquorice.
The raw material medicaments and the dosage formula are obtained by clinical experiments of an inventor for many years, and the medicaments have obvious treatment effect within the dosage range.
A medicine for quickly treating hyperplasia of mammary glands is prepared from hawthorn, angelica dahurica, fingered citron, malt, kelp, poria cocos, citron, peach kernel, safflower, purple perilla, kudzu vine root, orange peel, rose, selfheal, angelica sinensis, turmeric, ginseng and liquorice by compatibility, and mutual synergistic effect is generated among the efficacies of the medicines.
In a prescription of a medicament for quickly treating hyperplasia of mammary glands, hawthorn has the effects of strengthening spleen and stomach, promoting blood circulation to remove blood stasis, reducing blood fat and the like, has multiple effects of resisting oxidation, resisting aging and the like, has a promoting effect on humoral immunity and cellular immunity of mice, has good effects of resisting tumors, inhibiting distortion and the like, and is proved by clinical research that the hawthorn can inhibit the biosynthesis of tumor cell DNA so as to prevent division and propagation of tumor cells; the angelica dahurica has the effects of dispelling wind and eliminating dampness, dredging orifices and relieving pain, reducing swelling and expelling pus, activating blood and dissolving stasis, and has the efficacies of immunoregulation, anti-inflammation, antibiosis, antivirus, antimicrobial, antioxidation, antimutation, antitumor, analgesia, blood pressure reduction and the like, and the angelica dahurica polysaccharide can inhibit active ingredients of tumor cell proliferation and has a prevention effect on possible malignant change of hyperplasia of mammary glands; the fingered citron has the effects of soothing liver, regulating qi, harmonizing stomach, relieving pain, eliminating dampness and reducing phlegm, has the efficacies of immunoregulation, anti-inflammation, antibiosis, mutation resistance, tumor resistance, antioxidation, anti-aging, depression resistance, blood fat reduction, blood sugar reduction, cough relieving, phlegm reduction and the like, and has good treatment effect on the hyperplasia of mammary glands due to obvious effects of soothing liver, relieving depression and relieving pain; the malt has the effects of regulating qi to promote digestion, soothing liver to relieve depression, strengthening spleen to stimulate appetite, removing lactation to reduce swelling, softening and firming, relieving fullness, soothing liver to relieve depression, and inhibiting prolactin release by pharmacological verification, so that the effects of eliminating breast lumps and distending pain are achieved; the kelp can reduce phlegm and soften hard masses, induce diuresis and reduce edema, and has the effects of enhancing immunity, resisting bacteria, viruses, oxidation and fatigue, resisting mutation, tumors, blood coagulation and radiation, reducing blood pressure, blood fat, blood sugar and the like; the tuckahoe has the effects of promoting diuresis and eliminating dampness, strengthening spleen and reinforcing middle warmer, nourishing heart and tranquilizing mind, has the efficacies of enhancing immunity, resisting inflammation, bacteria, viruses, oxidation, mutation, tumor, fatigue, aging, coagulation, blood sugar and blood fat, and the like, has strong effects of strengthening spleen and reducing phlegm, and has good curative effect on the hyperplasia of mammary glands accompanied by the constitution of spleen deficiency and phlegm dampness; the citron has the effects of soothing liver, regulating qi, relieving epigastric distention, reducing phlegm, relieving distension and pain, resisting inflammation, resisting virus and the like, and has better relieving effect on local swelling and pain of the hyperplasia of mammary glands; peach kernel has the effects of promoting blood circulation to remove blood stasis, relaxing bowel, clearing and activating the channels and collaterals, relieving cough and asthma, enhancing immunity, resisting inflammation, easing pain, resisting oxidation, resisting tumor, resisting thrombus, resisting blood coagulation, preventing myocardial infarction, preventing hepatic fibrosis and the like, can utilize the effects of promoting blood circulation to remove blood stasis, dredging collaterals, relieving pain and the like of peach kernel, and is beneficial to eliminating hyperplasia of mammary glands, lumps and pain; safflower promotes blood circulation to remove blood stasis, regulates menstruation and relieves pain, has the functions of improving myocardial energy metabolism, relieving myocardial hypoxic injury, improving cardiac function, dilating coronary artery, relieving myocardial ischemia, relaxing vascular smooth muscle, inhibiting vascular smooth muscle cell proliferation, inhibiting platelet aggregation and release, resisting blood coagulation, resisting thrombosis, resisting free radicals, resisting oxidation, resisting aging, resisting tumors and enhancing immunity, has obvious effects of removing blood stasis and relieving pain, and has no good effect of relieving the pain and swelling caused by the hyperplasia of mammary glands; the purple perilla has the effects of relieving pain, regulating qi, preventing miscarriage, reducing phlegm and arresting vomiting, has the effects of resisting inflammation, bacteria, microbes, viruses, allergy, blood fat, blood pressure, oxidation and free radicals, resisting tumors, stopping bleeding, resisting coagulation, calming and relieving pain, relieving cough and reducing phlegm, enhancing immunity, enhancing memory and the like, and has a good relieving effect on distending pain caused by hyperplasia of mammary glands; radix Puerariae has effects of relieving exterior syndrome, expelling pathogenic factors from muscles, invigorating yang, promoting eruption, promoting fluid production, quenching thirst, clearing heat, relieving diarrhea, removing blood stasis, dredging collaterals, lowering blood pressure, reducing blood lipid, lowering blood sugar, preventing myocardial ischemia and myocardial infarction, resisting arrhythmia, arteriosclerosis, resisting mutation, oxidation, resisting tumor, and protecting potential senile diseases. Puerarin in radix Puerariae has plant estrogen component, can exert endogenous estrogen effect without side effect of endogenous estrogen, is beneficial to in vivo estrogen balance, and is beneficial to preventing and treating hyperplasia of mammary glands; the orange peel has the effects of regulating qi, strengthening spleen, eliminating dampness, reducing phlegm, relieving cough and asthma, has the effects of immunoregulation, antibiosis, anti-inflammation, cardiotonic, antishock, antioxidation, anti-aging, anti-tumor, anti-allergy, bidirectional regulation on intestinal smooth muscle, blood pressure increase and the like, can regulate estrogen level, and has good effects on hyperplasia pain, inflammation and swelling of mammary glands caused by unbalanced estrogen level; the rose has the effects of promoting qi circulation, relieving depression, regulating blood circulation, dissipating blood stasis, relieving swelling and pain, maintaining beauty and keeping young, has the efficacies of resisting inflammation, resisting virus, resisting oxidation, resisting tumor, expanding coronary artery, reducing blood sugar, detoxifying and benefiting gallbladder, is effective on regurgitation, vomiting, discomfort after drinking, constipation and migraine, has the functions of relieving pain, dissipating stagnation, relieving swelling and dissipating blood stasis on hyperplasia of mammary glands, and has particularly obvious treatment effect on premenstrual breast distending pain; the selfheal has the effects of clearing liver, improving vision, reducing swelling and dissipating stagnation, and has the effects of enhancing immunity, resisting inflammation, bacteria and viruses, resisting AIDS virus, allergy, blood pressure and blood sugar, resisting oxidation, free radicals, mutation, tumors, liver protection, cough and phlegm, and the like; the angelica has the effects of enriching and activating blood, regulating menstruation and relieving pain, relaxing bowel, enhancing immunologic function, promoting hematopoietic function, enhancing heart blood supply, expanding blood vessels, reducing vascular resistance, resisting atherosclerosis, arrhythmia, platelet aggregation, thrombus, oxidation, free radicals, tumors, inflammation, radiation, pain, neuronal degeneration in hypoxia, memory loss and the like, and is preferably used for patients with hyperplasia of mammary glands accompanied with blood deficiency and blood stasis; the turmeric has the effects of breaking blood and promoting qi circulation, and relieving dysmenorrheal and pain, has the effects of improving the immunologic function, resisting inflammation, fungi, microorganisms and oxidation, resisting platelet aggregation, resisting atherosclerosis, reducing blood fat, resisting free radicals, inhibiting stellate cell proliferation, resisting tumors, fibrosis and liver injury, benefiting gallbladder, preventing prostatic hyperplasia, resisting AIDS virus, protecting kidney function, resisting ulcer, protecting skin and the like, and has a certain effect of relieving swelling and pain caused by hyperplasia of mammary glands; the ginseng strengthens the body resistance to eliminate pathogenic factors, greatly supplements primordial qi, has the effects of improving immunity, regulating endocrine function, prolonging cell life, eliminating free radicals, resisting oxidation, mutation and tumor, improving cardiovascular and the like, and can help improve the disease resistance of the body weakness type hyperplasia of mammary glands; the liquorice has the effects of moistening lung for arresting cough, tonifying qi and kidney, relieving spasm and pain, harmonizing and detoxifying, enhancing immunity, resisting inflammation, bacteria, virus, arrhythmia, ulcer, oxidation, aging, tumor and the like, and has good relieving effect on local lump pain caused by hyperplasia of mammary glands.
In the research of the traditional Chinese medicine for treating the hyperplasia of mammary glands, the inventor considers that the treatment effect of the traditional Chinese medicine is various, not only the balance problem of estrogen and progestogen in a body is considered, but also the hyperplasia of mammary glands is related to factors such as increase of free radicals, abnormal antioxidant system and the like due to complex pathogenesis reasons, and the inventor pays attention to the prevention of oxygen free radical injury resistance and lipid peroxidation injury resistance besides the relative balance of estrogen and progestogen, so the medicine selection ideas in the aspects are embodied in the formula.
Clinical research proves that the medicine of the invention has the advantages that in the aspect of breast morphological change, partial cases suggest that acinar cavities are reduced, the number of lobules and acini is reduced, and the volume is reduced; the medicine also has certain effect on correcting hormone imbalance, the hormone proportion imbalance phenomenon of some patients is obviously improved, and related symptoms are improved; the phagocytic function of a mononuclear macrophage system is obviously improved after the systemic treatment of partial patients with low immune function, and the delayed skin hypersensitivity mediated by T cells is promoted; the hemorheology indexes of some patients are improved after treatment, and the indexes of partial patients such as whole blood viscosity, plasma viscosity, blood sedimentation, pressure and the like are obviously improved. The improvement of the above indexes indicates that the curative effect of the medicine of the present invention is reflected in various aspects.
A medicine for quickly treating the hyperplasia of mammary glands has the functions of promoting blood circulation to remove meridian obstruction, dispersing stagnated liver qi, relieving depression, regulating qi, dispersing swelling, invigorating spleen and regulating menstruation. Moreover, the medicines are not the superposition of the effects of single traditional Chinese medicines, but are scientifically prepared on the basis of the treatment based on syndrome differentiation of the traditional Chinese medicine, and the formula effect of 1+1 to more than 2 is realized. The main functions of the traditional Chinese medicine are mainly reflected in the aspects of relieving symptoms such as hyperplasia of mammary glands, local swelling and pain of breasts, dysphoria and depression, irregular menstruation, emotional discomfort, limb weakness and the like, and the traditional Chinese medicine has especially obvious treatment effect on relieving a series of symptoms shown by hyperplasia of mammary glands.
Moreover, the pharmacological actions of the medicines have related pharmacological research or animal test conclusions.
The medicine can be prepared into oral administration dosage forms by adopting a conventional method of Chinese medicine preparations. The medicine of the invention can be prepared by grinding the raw materials into powder and uniformly mixing the powder into powder, granules, oral liquid and beverage. Or decocting the raw materials with water, concentrating into paste, drying to obtain effective components, and preparing into various oral preparations according to the requirement, but the invention is not limited in scope.
The medicine can also be used for extracting effective components by adopting methods such as semi-bionic extraction (SBE), Supercritical Fluid Extraction (SFE), microwave extraction (MAE), enzyme extraction (ETE), ultrasonic extraction (UAE), semi-bionic extraction (SEB), squeezing extraction (PE), Continuous Countercurrent Extraction (CCE), tissue disruption extraction (STE), heating-free extraction (HFE), normal-temperature ultrahigh-pressure extraction (U HPE), Air Explosion Extraction (AEE) and the like, and the extraction methods are all in the protection range of the medicine.
The following capsule formulations are preferred for use in the present invention.
The preparation method of the medicine comprises the following steps:
(1) weighing the raw materials in proportion for later use;
(2) 18 Chinese medicaments of hawthorn, angelica dahurica, fingered citron, malt, kelp, tuckahoe, citron, peach kernel, safflower, purple perilla, kudzu root, orange peel, rose, selfheal, angelica, turmeric, ginseng and liquorice in the weight ratio are delivered to a professional Chinese medicament pharmaceutical factory for extraction after being accepted;
(3) extracting by a pharmaceutical factory according to a conventional method and a conventional program for extracting traditional Chinese medicines;
(4) packaging the extracted medicinal powder into bottled capsules, wherein each bottle contains 60 capsules, and each capsule contains 0.45g of the Chinese medicinal extract powder;
(5) or making the extracted medicine into granules, wherein each bag contains 6g of traditional Chinese medicine extraction powder;
(6) the finished product is delivered to clinical trials by the pharmaceutical factory.
The clinical use results show that the medicine of the invention has the following advantages:
1. the invention selects natural edible plant medicines as raw materials, and each component accords with the regulation of a pharmaceutical law and the principle of a traditional Chinese medicine prescription, and highlights the basic characteristics of the combination of traditional Chinese medicine syndrome differentiation and western medicine disease differentiation and the combination of etiology treatment and symptomatic treatment;
2. the medicine of the invention does not need to be decocted after being extracted, has good taste and convenient taking, is nontoxic and harmless before and after the prescription of each medicine, and has no side effect after being taken with normal dosage;
3. the medicine has good treatment effect on the low immune function of patients and various symptoms caused by the low immune function of the patients, has good prevention and health care effects, and has wide application range;
4. the medicine is selected from the varieties which can be used as both medicine and food and are regulated by Ministry of health, the safety is higher, and the medicine can be taken by patients with low immunity for a long time in treatment;
5. the medicine has good compatibility, and has certain treatment effect on symptoms such as hyperplasia of mammary glands, local swelling and pain, dysphoria and depression, irregular menstruation, emotional distress, limb weakness and the like which are easy to appear in patients;
6. the medicine of the invention treats both principal and secondary aspect of disease, and has quick effect.
Detailed Description
The effect of the present invention will be further illustrated by the following examples and clinical application statistics.
Example 1: capsule preparation
15kg of hawthorn, 20kg of angelica dahurica, 20kg of fingered citron, 20kg of malt, 15kg of kelp, 15kg of tuckahoe, 20kg of citron, 20kg of peach kernel, 15kg of safflower, 20kg of perilla, 20kg of kudzu root, 15kg of orange peel, 18kg of rose, 20kg of selfheal, 18kg of angelica, 20kg of turmeric, 20kg of ginseng and 20kg of liquorice, and the raw materials are extracted and processed by a professional Chinese medicine pharmacy factory and prepared into capsules, wherein each capsule is 0.45g, 4 capsules each time and 3 times a day.
Example 2: preparation of granules
15kg of hawthorn, 20kg of angelica dahurica, 20kg of fingered citron, 20kg of malt, 15kg of kelp, 15kg of tuckahoe, 20kg of citron, 20kg of peach kernel, 15kg of safflower, 20kg of perilla, 20kg of kudzu root, 15kg of orange peel, 18kg of rose, 20kg of selfheal, 18kg of angelica, 20kg of turmeric, 20kg of ginseng and 20kg of liquorice, are extracted and processed by a professional Chinese medicine pharmacy, are prepared into granules, 6g of the granules are prepared in each bag, 1 bag is taken every time, and the granules are taken with water 3 times a day.
Clinical observation of the drug of the invention
One, general data
In order to prove the clinical curative effect of the medicine, in 7 months to 6 months of 2019 in 2018, the gynecological outpatient service of traditional Chinese medicine is used for treating 112 cases of patients with hyperplasia of mammary glands, and the age is 17-55 years; the observed group and the control group were divided into 56 cases each by the digital random table method. The ages of the observation groups are 17-55 years, and the average age (35.61 +/-11.32) is the age; the course of the disease (16.26 +/-3.97) months. The age of the control group is 17-54 years, and the average age (35.97 +/-10.79) years; the course of the disease (17.01 +/-4.06) months. The general clinical data of age, disease course, etc. of two groups have no significant difference after statistical treatment and are comparable (P is more than 0.05).
Diagnostic criteria: the diagnosis is confirmed by clinical examination, B-ultrasonic examination and the like according to the diagnosis standard established by the special subject group of Chinese national academy of traditional Chinese medicine and surgery. The main clinical manifestations are breast swelling and lumps, part of patients have periodicity, pain is aggravated before menstruation and relieved or disappeared after menstruation, and breast pain in the whole menstrual period of part of patients; the physical examination shows that one or two mammary glands are subjected to diffuse thickening, can be limited to one part of the mammary glands, can also be dispersed in the whole mammary glands, and the lumps are granular, nodular or flaky, have different sizes, are tough and not hard, are often multiple and are not well-demarcated with the surrounding tissues; the ultrasonic examination finds that the breast body structure is disordered and the echoes are uneven.
And (3) inclusion standard: the age is 17-55 years old, and the diagnosis standard of the hyperplasia of mammary glands is met. The patient has no major consumptive diseases and good compliance through approval agreement of the ethical committee of the hospital, and voluntarily signs an informed consent.
Exclusion criteria: breast cancer patients; patients with severe diseases of the heart, brain, lung, liver, kidney, hematopoietic system and immune system are combined; patients who have received hormone therapy or taken contraceptives within 6 months; pregnant or lactating women; the patient can not normally participate in the clinical observer; without signing an informed consent.
Second, test method
Comparison medication: both groups were administered continuously for 3 months. The observation group takes the medicinal granules of the invention with 6g per bag, 1 bag per time and 3 times per day after being taken with water; the control group oral Rupixiao tablet (prepared from cornu Cervi, herba Taraxaci, thallus laminariae, Trichosanthis radix, caulis Spatholobi, Notoginseng radix, radix Paeoniae Rubra, Sargassum, radix Rhapontici, radix aucklandiae, radix scrophulariae, cortex moutan, Glycyrrhrizae radix, fructus forsythiae, Carthami flos, etc., SHENYANG Chinese medicinal preparation company Limited, batch No. Z21020757), 3 granules each time, 3 times daily.
Observation indexes are as follows: (1)2 groups of treatment effects; (2) observing the symptoms of breast lump size, breast pain degree, menstruation condition, chest distress and taixiong before and after treatment; (3) adverse reactions were associated after treatment.
The curative effect standard is as follows: refer to the guidance principle of clinical research of new Chinese medicine and make an opinion on the special subject group of mastopathy of the surgical society of the national medical society of China. The clinical cure is as follows: the lump disappears, the breast pain is relieved, the molybdenum target tablet shows that the breast density is uniform, the proliferation organism disappears, and the breast does not relapse after 3 months of stopping the medicine; the effect is shown: the maximum diameter of the lump is reduced by more than 1/2, the breast pain disappears, and the molybdenum target tablet shows that the proliferation is obviously reduced; the method has the following advantages: the breast pain is relieved when the maximum diameter of the lump is not reduced enough 1/2, or the breast pain is not relieved when the maximum diameter of the lump is reduced by more than 1/2, and the molybdenum target tablet shows that the proliferation is reduced; and (4) invalidation: the lump is not reduced or enlarged and hardened, or the lump is not reduced although the breast pain is relieved, and the molybdenum target photographic examination result is not obviously improved before treatment.
The symptoms were observed: the change of the main clinical symptoms of 2 groups of patients before and after treatment was observed, and quantitative score comparison was performed by drawing up quantitative scoring standards according to the symptoms in accordance with the "standard of curative effect for diagnosis of disease in traditional Chinese medicine" published by Nanjing university Press by the State administration of traditional Chinese medicine. Breast lumps: the mass is less than 1cm, 1 point; the mass is 1 cm-2 cm, 2 points; the mass is more than 2cm and 3 points; breast pain: dull pain without tenderness, 1 point; dull pain with tenderness, 2 points; pain and tenderness were evident, 3 points; pain was severe and did not touch or affect activity, score 4. Menstruation condition: the amount is small, and the color is light, 0.5 min; the amount is small, dark and 1 point. Chest distress and frequent sigh: mild chest distress with no hesitation, 0.5 point; chest distress with taixiong, 1 point; chest oppression with hypochondriac distension due to frequent sighing is 1.5 minutes.
Statistical analysis: statistical analysis is carried out by adopting SPSS10.0 for windows statistical software, and x is adopted for comparing the two groups of curative effects2The test shows that P is less than 0.05, which shows that the difference is statistical.
And (3) analyzing the curative effect: (1) the clinical efficacy of 2 groups is compared: the observation group comprises 56 clinical cases with 20 cases (35.71%), 18 cases with obvious effect (32.14%), 13 cases with effect (23.21%), 5 cases with no effect (8.93%) and total effective rate of 91.07%; the control group 56 cases are clinically cured by 10 cases (17.86%), the effective 12 cases (21.43%), the effective 15 cases (26.79%), the ineffective 19 cases (33.93%) and the total effective rate of 66.07%. The observed group is superior to the control group, and P is less than 0.05. (2) Comparison of clinical symptom scores before and after treatment in group 2: observing breast lumps of the group 2.15 +/-0.53 before treatment and 0.7 +/-0.33 after treatment; 2.66 +/-0.77 before and 1.01 +/-0.21 after treatment of breast swelling; 0.89 plus or minus 0.07 before menstruation and 0.15 plus or minus 0.06 after menstruation; 1.15 plus or minus 0.14 before chest distress tai ling treatment and 0.31 plus or minus 0.16 after treatment. 2.17 +/-0.51 before treatment and 0.97 +/-0.35 after treatment of the breast lumps in the control group; 2.63 plus or minus 0.79 before treatment and 1.13 plus or minus 0.37 after treatment of breast swelling; 0.87 + -0.06 before treatment and 0.91 + -0.03 after treatment of menstrual condition; 1.16 +/-0.13 before chest distress taiji treatment and 1.11 +/-0.19 after treatment. (3) No relevant adverse reaction is seen after the treatment of the group 2. Clinical research results show that the medicine has obvious advantages in the aspect of curative effect of treating the hyperplasia of mammary glands and has certain clinical popularization value.
Claims (7)
2. the medicine for rapidly treating hyperplasia of mammary glands according to claim 1, wherein the formula is that the capsule is prepared by adopting a conventional process of Chinese materia medica preparation.
3. The medicament for rapidly treating the hyperplasia of mammary glands according to claim 1, wherein the formulation is prepared into tablets by adopting a conventional process of Chinese medicinal preparation.
4. The medicine for rapidly treating hyperplasia of mammary glands according to claim 1, wherein the formulation is prepared into powder or granules by a conventional process of Chinese materia medica preparation.
5. The medicament for rapidly treating the hyperplasia of mammary glands according to claim 1, wherein the formulation is characterized in that the medicament is prepared into water pills, honey pills, water honey pills, concentrated pills or dropping pills by adopting a conventional process of Chinese medicinal preparations.
6. The medicine for rapidly treating hyperplasia of mammary glands according to claim 1, wherein the formula is that the medicine is prepared into oral liquid and paste by adopting a conventional process of Chinese materia medica pharmaceutics.
7. The medicine for rapidly treating hyperplasia of mammary glands according to claim 1, wherein the formula is that the medicine is prepared into tea by adopting a conventional process of Chinese materia medica pharmaceutics.
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