CN112812949A

CN112812949A - Preservation pipe is used to sampling swab prescreening

Info

Publication number: CN112812949A
Application number: CN202110019956.6A
Authority: CN
Inventors: 方鹏宇; 蒋析文
Original assignee: Daan Gene Co Ltd of Sun Yat Sen University
Current assignee: Daan Gene Co Ltd of Sun Yat Sen University
Priority date: 2021-01-07
Filing date: 2021-01-07
Publication date: 2021-05-18

Abstract

The invention relates to the technical field of sample preservation, in particular to a preservation tube for a primary screen of a sampling swab, which comprises a tube body and a tube cover which are detachably connected, wherein a plurality of first cavities are arranged in the tube body and are uniformly arranged in a surrounding and communicating manner, a sample releasing agent flows among the first cavities, and the central axis of the first cavities deviates from the central axis of the tube body. The invention omits the processes of oscillation elution and sample nucleic acid extraction, the sample nucleic acid is quickly released in the sample releasing agent, the field extraction and the field detection can be realized, and the infection risk caused by sample transfer is avoided; the swab is vertically arranged in the first cavity deviated from the center of the tube body, so that an operation space is provided for sampling operation, and detection faults caused by mutual collision of the sampling swab and the pipette head are avoided; in addition, the invention can simultaneously carry out primary screening on a plurality of samples, and can effectively improve the detection efficiency and reduce the detection cost when the number of detection groups is large.

Description

Preservation pipe is used to sampling swab prescreening

Technical Field

The invention relates to the technical field of sample preservation, in particular to a preservation tube for primary screening of a sampling swab.

Background

In the field of in vitro diagnosis, particularly gene diagnosis, a sample separated from a human body needs to be collected for detection, and the method for sampling by adopting a sampling swab is a simple, painless and noninvasive DNA specimen collection method. The method is suitable for collecting DNA samples of people of any age group. Swabs are commonly used as a tool for medical examination to collect microorganisms, exfoliated cells, or secretions, and the sampled swabs are stored in storage tubes for inspection.

Chinese patent CN210843181U discloses a swab sample storage tube, which comprises a tube body and a cover body that are detachably connected, wherein a sample swab collects a patient sample and then is stored in the tube body in a sealed manner, and then is sent into a laboratory to extract nucleic acid and detect, but at present, the method has many disadvantages: (1) in the process of extracting nucleic acid in a laboratory, sample nucleic acid on the swab needs to be shaken and eluted, so that the operation is complicated; (2) the collected sample needs to be subjected to nucleic acid extraction by using a nucleic acid extraction or purification kit so as to obtain pure nucleic acid; (3) can not be carried out on site; (4) the sample needs to be transferred to a special laboratory for sample extraction and detection, so that the risk of personnel infection caused by the sample transfer process is increased; (5) in the detection process, as the storage tube is not provided with a fixed sampling swab structure, the swab is easy to incline in the storage tube, so that the absorption of a sample is influenced, and particularly when an automatic instrument is used for extraction, the swab is easy to collide with a pipette tip, so that the sample absorption fault is caused, and the detection failure is caused; (6) each storage tube can only be used for storing one swab sample, and the detection efficiency is low when the number of detection groups is large.

Disclosure of Invention

The invention aims to overcome the defects in the prior art, and provides the storage tube for the primary screening of the sampling swabs, which does not need oscillation elution, can facilitate subsequent detection and sampling, can simultaneously perform the primary screening of a plurality of sampling swab samples and effectively improve the primary screening efficiency.

In order to solve the technical problems, the invention adopts the technical scheme that:

the utility model provides a sampling swab is preservation pipe for primary screen, including body and the tube cap that can dismantle the connection, be equipped with a plurality of first cavitys and a plurality of first cavitys that are used for placing the sampling swab in the body and evenly encircle the intercommunication setting, if do it has sample release agent to flow between the first cavity, the central axis of first cavity deviate in the central axis of body.

The invention relates to a storage tube for primary screening of sampling swabs, wherein a plurality of sampling swabs are respectively placed in corresponding first cavities, move up and down and are eluted in a rotating way in the first cavities, sample nucleic acid of each sampling swab is uniformly distributed in a sample releasing agent, and the sample releasing agent can be used for detection after being sucked: when the detection result shows negative, all the sample nucleic acids are negative; if the detection result is positive, at least one group of sample nucleic acids in the sample nucleic acids is positive, and the group of sample nucleic acids needs to be subjected to fine detection. The invention omits the process of extracting the sample nucleic acid by shaking elution, and the sample release agent flows in the preservation tube, so that the release of the sample nucleic acid can be completed by standing for 5-10 minutes at normal temperature, the field extraction and the field detection can be realized, and the personnel infection risk caused by sample transfer is avoided; the swab is vertically arranged in the first cavity which is deviated from the center of the tube body, so that an operation space is provided for sampling operation, the nucleic acid detection operation process is simplified, the clinical test operation is facilitated, and the infection risk in the detection process is reduced; in addition, the invention can simultaneously carry out primary screening on a plurality of samples, and can effectively improve the detection efficiency and reduce the detection cost when the number of detection groups is large.

Furthermore, a support column is arranged at the center inside the pipe body, and a plurality of groups of first cavities uniformly surround the support column and the inner wall of the pipe body. The support column and the inner wall of the tube body jointly support the sampling swab, so that the sampling swab can stably stand in the first cavity, and the sampling swab is prevented from being inclined to generate adverse effects on detection sampling.

Further, the height of the support column is lower than that of the first cavities, a second cavity for detecting and sampling is formed at the communication position of the upper part of the support column and each first cavity, and the second cavity above the support column is used as a sampling space.

Furthermore, the first cavity is a cylindrical hole, and the wall surface of the cylindrical hole is tangent to the inner wall surface of the pipe body and is overlapped with part of the outer wall surface of the support column. The sample releasing agent mixed with the sample nucleic acid is arranged in a second cavity, the central axis of the second cavity is coincident with the central axis of the tube body, and the position of the second cavity is limited to be beneficial to subsequent automatic detection and sampling; the pipe inner wall is located in the subsides of first cavity lateral part for the sampling swab pastes in the pipe inner wall, makes the sampling swab can stand in first cavity steadily, prevents that the slope of sampling swab from producing adverse effect to detecting the sample.

Further, the body top is equipped with the first connecting portion that are used for connecting the tube cap, and the body bottom is equipped with the fixed part. The first connecting part is used for connecting the tube cover and the tube body and sealing and storing the sampling swab and the sample releasing agent in the storage tube; the fixed part is used for the body and matches between fixed station or the fixed instrument, does benefit to the automation that realizes the rotatory operation of tube cap.

Furthermore, the top of the first cavities is connected with second connecting parts, and the second connecting parts surround the outer edge of the top of the first cavities and the inner wall of the tube body. After the tube body is connected with the tube cover, a closed space is formed among the second connecting part, the first cavity, the tube body and the tube cover, and the swab and the sample releasing agent are stored in the closed space, so that the storage stability of the sample can be effectively ensured.

Furthermore, a plurality of first convex parts are arranged on the inner wall of the first cavity. On the one hand, the nucleic acid sample can be well eluted when the sampling swab is moved up and down, rotated and rotated, and on the other hand, the sampling swab is beneficial to being stably stood in the second cavity and is not easy to topple over.

Furthermore, the first convex part is a first convex rib, and the first convex rib is one or a combination of a plurality of vertical ribs, transverse ribs, inclined ribs and spiral ribs. The shape of the first ridge is not intended to be limiting, and other frictional structures that increase the friction between the sampling swab and the inner wall of the second chamber to improve the elution of the sampling swab may be suitable for use in the present invention.

Further, the first convex part is a first convex point. The first salient points can be connected to form one or a combination of a plurality of vertical edge structures, transverse edge structures, oblique edge structures and spiral edge structures, irregular edge structures can also be processed as required, the swab has a good elution effect when moving up and down or rotating the sampling swab, and the using amount of preparation raw materials can be saved.

Furthermore, a plurality of second convex parts are uniformly distributed at the bottom of the inner side of the first cavity. The first convex part of the side part has an elution effect on the sample nucleic acid at the side part of the sampling swab, and the second convex part at the bottom has an elution effect on the sample nucleic acid at the bottom of the sampling swab, so that the elution effect on the sample on the sampling swab when the sampling swab moves up and down and rotates can be improved.

Furthermore, the second convex part is a second convex rib, one end of the second convex rib is arranged in the center of the bottom of the first cavity, and the other end of the second convex rib is connected with the first convex part. The position and shape of the second rib are preferably set to simplify the mold structure, simplify the molding process, improve the design appearance, and improve the elution effect, and are not intended to be restrictive in the present invention.

Further, the second convex part is a second convex point. The first salient points can be connected to form a radial edge structure which is radially distributed along the bottom of the first cavity, so that the rotary sampling swab has a good elution effect, and the consumption of raw materials for preparation can be saved.

Compared with the prior art, the invention has the beneficial effects that:

the storage tube for primary screening of the sampling swab saves the process of extracting the sample nucleic acid by shaking elution, can realize the field extraction and the field detection of the sample nucleic acid, and avoids the personnel infection risk caused by sample transfer; the swab is vertically arranged in the first cavity which is deviated from the center of the tube body, so that an operation space is provided for sampling operation, the nucleic acid detection operation process can be simplified, the detection fault caused by mutual collision of the pipette head and the sampling swab is avoided, and the infection risk in the detection process is reduced; in addition, the preservation tube for primary screening of the sampling swabs can simultaneously carry out primary screening on a plurality of sampling swabs, and can effectively improve the detection efficiency and reduce the detection cost when the number of detection groups is large.

Drawings

FIG. 1 is a perspective view of a storage tube for a primary screen of a sampling swab according to one embodiment;

FIG. 2 is a schematic view showing the shape of a storage tube for a primary screening of a sampling swab according to one embodiment;

FIG. 3 is a cross-sectional view taken along A-A of FIG. 2;

FIG. 4 is a bottom view of a storage tube for a primary screen of a sampling swab according to one embodiment;

FIG. 5 is a schematic view showing the first chamber and the second chamber communicating with each other according to the second embodiment;

FIG. 6 is a schematic view I of the third embodiment showing the communication between the first chamber and the second chamber;

FIG. 7 is a schematic view II illustrating the communication between the first chamber and the second chamber in the third embodiment;

FIG. 8 is a schematic view showing the first chamber and the second chamber communicating with each other in the fourth embodiment;

in the drawings: 1-a pipe body; 11-a first cavity; 12-a second cavity; 13-a first connection; 14-a fixed part; 15-a second connection; 16-a first projection; 17-a second projection; 2-a tube cover; and 3-support column.

Detailed Description

The present invention will be further described with reference to the following embodiments. Wherein the showings are for the purpose of illustration only and are shown by way of illustration only and not in actual form, and are not to be construed as limiting the present patent; to better illustrate the embodiments of the present invention, some components of the drawings may be omitted, enlarged or reduced, and do not represent the size of an actual product; it will be understood by those skilled in the art that certain well-known structures in the drawings and descriptions thereof may be omitted.

The same or similar reference numerals in the drawings of the embodiments of the present invention correspond to the same or similar components; in the description of the present invention, it should be understood that if there is an orientation or positional relationship indicated by the terms "upper", "lower", "left", "right", etc. based on the orientation or positional relationship shown in the drawings, it is only for convenience of description and simplification of description, but it is not intended to indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and therefore, the terms describing the positional relationship in the drawings are only for illustrative purposes and are not to be construed as limitations of the present patent, and specific meanings of the above terms may be understood by those skilled in the art according to specific situations.

Example one

Fig. 1 to 4 show a first embodiment of a storage tube for a sampling swab prescreening of the present invention, which includes a detachable tube body 1 and a tube cover 2, wherein a first cavity 11 for placing a sampling swab is disposed in the tube body 1, a plurality of groups of first cavities 11 are uniformly arranged in a surrounding and communicating manner, a sample releasing agent flows between the plurality of groups of first cavities 11, and a central axis of the first cavities 11 is offset from a central axis of the tube body 1.

When the embodiment is implemented, a plurality of sampling swabs are placed in the first cavity 11 after sampling, move up and down and carry out rotary elution in the first cavity 11, sample nucleic acid of each sampling swab is uniformly distributed in the sample releasing agent, and the sample releasing agent is absorbed to be used for detection: when the detection result shows negative, all the sample nucleic acids are negative; if the detection result is positive, at least one group of sample nucleic acids in the sample nucleic acids is positive, and the group of sample nucleic acids needs to be subjected to fine detection. It can be seen that, in this embodiment: (1) the process of extracting the nucleic acid of the sample by shaking elution can be omitted; (2) because the sample releasing agent flows in the storage tube, the collected swab sample is not required to be extracted by a nucleic acid extracting agent or a purification kit, and a pure nucleic acid sample can be obtained; (3) standing at normal temperature for 5-10 minutes to complete the release of the nucleic acid of the sample, and realizing on-site extraction; (4) the field extraction and the field detection of the sample can be realized, and the personnel infection risk caused in the sample transfer process is avoided; (5) the swab is vertically arranged in the first cavity 11 which is arranged in a way of deviating from the center of the tube body 1, so that an operation space is provided for sampling operation, the nucleic acid detection operation process is simplified, and the infection risk in the detection process is reduced; (6) this embodiment can carry out the primary screen to a plurality of samples simultaneously, when the detection colony number is huge, can effectively improve detection efficiency and reduce the detection cost.

In order to stably stand the sampling swab in the first cavity 11, the present embodiment may slightly press the head of the sampling swab by setting the size of the first cavity 11 such that the inner wall of the first cavity 11. In particular, the first cavity 11 is sized between the sampling swab head maximum diameter and the sampling swab shaft diameter. It should be noted, however, that the first cavity 11 is preferably sized to provide a good stabilization of the sampling swab and is not intended as a limiting provision of the present invention. While aspirating the sample: on one hand, the first cavity 11 is deviated from the central axis of the storage tube, so that space is provided for sampling; on one hand, the sampling swab can stably stand in the preservation tube vertically; when using automatic instrument to get liquid, the liquid-transfering gun head is difficult for colliding with the sampling swab to avoid the sample to absorb the detection failure that the trouble leads to. The bottom of the first cavity 11 of this embodiment can be set as an arc surface structure, a plane structure or a conical surface structure as required, and when the bottom is set as the conical surface structure, the diameter of the section of the conical surface structure is gradually reduced from top to bottom, so as to perform a better squeezing action on the head of the sampling swab and promote the sample nucleic acid to be dissolved into the sample releasing agent.

In addition, this embodiment can also set up a support column 3 in the inboard bottom center department of body 1, and the even surrounding of multiunit first cavity 11 is between support column 3 and body 1 inner wall. Specifically, when the first cavity 11 is a cylindrical hole, a wall surface of the cylindrical hole is tangent to an inner wall surface of the pipe body 1 and overlaps with a part of an outer wall surface of the support column 3. So,

support column

3 and 1 inner wall of body support the sampling swab jointly for the sampling swab stands steadily in first cavity, prevents that the sampling swab slope from colliding the pipette head and leading to the sample to absorb the trouble and lead to detecting to lose.

In order to communicate the plurality of first cavities 11 with each other, the first cavities 11 of this embodiment are cylindrical holes, the plurality of cylindrical holes are arranged in a surrounding and staggered manner, the wall surfaces of the cylindrical holes are tangent to the inner wall surface of the pipe body and coincide with part of the outer wall surface of the support column, and the cross section of each cylindrical hole can be designed into a sector with a central angle smaller than 180 degrees so as to arrange more first cavities 11; the support column 3 sets up with the wall of first cavity 11 is relative, and

support column

3 and 1 inner wall of tube support the sampling swab jointly for the sampling swab is steadily stood in first cavity, prevents that the slope of sampling swab from producing adverse effect to detecting the sample. The height of the supporting column 3 is lower than that of the first cavities 11, second cavities 12 for detecting and sampling are formed at the upper part of the supporting column 3 and the communication positions of the first cavities 11, the first cavities 11 are communicated with the second cavities 12, and the second cavities 12 above the supporting column 3 are used as sampling spaces.

In order to further limit the storage position of the sampling swab in the storage tube and avoid the improper position of the sampling swab from affecting the detection sampling operation, the present embodiment further limits the distribution positions of the second cavity 12 and the first cavity 11 in the tube body 1. Specifically, the central axis of the second cavity 12 of this embodiment coincides with the central axis of body 1, and the inside wall of body 1 is located in the subsides of 11 lateral parts of first cavity, so, can be convenient for the sampling instrument stretches into this release of suction sample in the second cavity 12, and the inside wall of body 1 is hugged closely to sampling swab one side in first cavity 11, makes to get the sampling swab and erects the storage more steadily, and can avoid the detection trouble that pipette tip and sampling swab collided and lead to.

In the process of transporting and transferring the storage tube, the storage tube is sealed, so the top of the tube body 1 is provided with a first connecting part 13 for connecting the tube cover 2; in order to be suitable for the automatic operation of the instrument in the detection process, the fixing portion 14 is disposed at the bottom of the tube 1 in this embodiment, the structure of the fixing portion 14 may be set according to the structure of the instrument or the fixing table, in this embodiment, one end of the fixing portion 14 is flush with the bottom of the tube 1, and the other end of the fixing portion 14 may extend upward to the top edges of the second cavity 12 and the first cavity 11; one side of the first cavity 11 is tangent to the fixing portion 14, and the other side is attached to the inner wall of the tube 1. In the embodiment, the connecting part is an external thread arranged on the outer wall of the pipe body 1, the pipe body 1 is connected with the pipe cover 2 through the thread, the connection is stable, and the automatic operation can be conveniently realized; as shown in fig. 3, the fixing portion 14 is a cross structure, and the cross structure is matched and fixed with the fixing table when the tube cap 2 is operated to prevent the tube body 1 from rotating along with the tube cap 2 when the tube cap 2 is rotated, but it should be noted that the cross structure is preferable for achieving both good fixing effect and good processing and forming performance, and is not a limitation of the present invention, and the structure of the fixing portion 14 in this embodiment can be designed according to the fixing table or a fixing instrument and can be adapted to the fixing table or the fixing instrument. For example, the number of the constituent edges of the fixing portion 14 in this embodiment may be equal to the number of the first cavities 11, for example, when five groups of the first cavities 11 are provided, the fixing portion 14 has five edges, one end of the five edges is connected to the axis of the tube body 1, the five edges are uniformly distributed along the radial direction of the tube body 1, and the axis of each first cavity 11 passes through the plane where the corresponding edge is located, which not only plays a role of fixing, but also has an attractive appearance and plays a role of reinforcing the bottom of the first cavity 11.

In order to reasonably distribute the position of the first cavity 11 in the tube body 1, the second connecting portion 15 is connected to the top of the first cavity 11, and the second connecting portion 15 may be in a circular truncated cone shape and surround between the outer edge of the first cavity 11 and the inner wall of the tube body 1, as shown in fig. 2. After the tube body 1 is connected with the tube cap 2, a closed space is formed among the second connecting part 15, the second cavity 12, the first cavity 11, the tube body 1 and the tube cap 2, as shown in fig. 4, the swab and the sample releasing agent are stored in the closed space, and the stability of sample storage can be effectively ensured. In addition, the second connecting portion 15, the second cavity 12 and the first cavity 11 of the present embodiment may be an integrally formed structure.

In order to endow the preservation tube with better performance, the wall thickness of the tube body 1, the wall thickness of the second cavity 12, the wall thickness of the first cavity 11, the thickness of the fixing part 14, the thickness of the second connecting part 15 and other dimensions of the preservation tube are equal, so that the cooling effect in the forming process is ensured. Of course, this is only preferred for obtaining a better performing holding tube with existing production equipment and is not intended as a limiting provision of the invention.

Example two

This embodiment is a second embodiment of the storage tube for a sampling swab prescreening of the present invention, and is the same as the first embodiment, except that the first cavities 11 are communicated with each other in the following manner: the first cavity 11 is a cylindrical hole, the wall of the first cavity 11 is a first tube, a second tube is coaxially arranged in the tube body 1, the second tube is a second cavity 12, the first tube is connected between the outer wall of the second tube and the inner wall of the tube body 1, a through hole or a through groove is arranged at the joint of the first tube and the second tube, as shown in fig. 5, the first cavity 11 is communicated with the second cavity 12, a sample releasing agent can freely flow between the first cavity 11 and the second cavity 12, namely, the sample releasing agent added in the second cavity 12 can flow into the first cavity 11, a sampling swab can vertically move and rotationally elute in the first cavity 11, sample nucleic acid is dissolved in the sample releasing agent, and the sample releasing agent containing the sample nucleic acid in the first cavity 11 can freely flow into the second cavity 12 to wait for sampling detection.

EXAMPLE III

This embodiment is a third embodiment of the storage tube for a sampling swab prescreening of the present invention, and is the same as the first embodiment, except that the first cavities 11 are communicated with each other in the following manner: as shown in fig. 7 (only one first cavity is shown in fig. 7, other first cavities are not shown, other first cavities uniformly surround between the wall of the second cavity and the inner wall of the tube body 1, the structure and size of each first cavity are the same), the first cavity 11 is a cylindrical hole, the wall of the first cavity 11 is a first tube, a second tube is coaxially arranged in the tube body 1, and the second tube is a second cavity 12, the first tube is connected between the outer wall of the second tube and the inner wall of the tube body, but no hole is formed in the side wall of the first tube and the side wall of the second tube, the tops of the first tube and the second tube are communicated, and at this time, enough sample sustained-release agent is added into the second cavity 12 to achieve the communication between the first cavity 11 and the second cavity 12. Specifically, the second cavity 12 is a tapered hole, and the depth of the first cavity 11 is greater than that of the second cavity 12, as shown in fig. 6. The second cavity 12 is provided with a tapered hole, so that the sample releasing agent is favorably collected in the second cavity 12, the liquid level depth of the sample releasing agent is increased, and the subsequent detection and sampling are favorably realized; the depth of the first cavity 11 is larger than that of the second cavity 12, the bottom of the first cavity 11 is located below the bottom of the second cavity 12, and the sampling swab can stably stand in the first cavity 11, so that the influence of the sampling swab toppling on the detection sampling operation is prevented.

Example four

This embodiment is a fourth embodiment of the storage tube for sampling swab prescreening of the present invention, and is the same as the embodiment, except that the first cavity 11 and the second cavity 12 are partially overlapped to form a first side edge and a second side edge, and the distance between the first side edge and the second side edge is not greater than the minimum diameter of the sampling swab, as shown in fig. 8 (only one first cavity is shown in fig. 7, other first cavities are not shown, other first cavities uniformly surround the second cavity wall and the inner wall of the tube body 1, and the structures and the sizes of the first cavities are the same). During implementation, the communication between the first cavity 11 and the second cavity 12 is not affected, the sample releasing agent can freely flow between the first cavity 11 and the second cavity 12, and the sampling swab in the first cavity 11 can be effectively prevented from inclining to one side of the second cavity 12. It should be noted that the provision of the gap between the first side edge and the second side edge is preferable for obtaining good processability and a stable sampling swab effect, and is not a limitation of the present invention, and the present invention may further include a side plate connected between the first side edge and the second side edge, and a hole or a groove formed in the side plate, so as to communicate the first cavity 11 and the second cavity 12 and prevent the sampling swab from tilting.

EXAMPLE five

The present embodiment is a fifth embodiment of the storage tube for primary sampling swab screening of the present invention, and is the same as the first embodiment, except that the inner wall of the first cavity 11 is provided with a plurality of first protrusions 16, so that on one hand, the sample nucleic acid can be well eluted when the sampling swab is moved up and down, rotated and rotated, no equipment is required to be adopted for oscillation elution, sample extraction and sample detection can be completed on site, and the infection risk caused by sample transfer is effectively avoided; on the one hand, the sampling swab is beneficial to being stably and vertically arranged in the first cavity 11 and not prone to toppling, and detection failure caused by detection faults due to mutual collision of the pipette head and the sampling swab is avoided.

Specifically, the first protrusion 16 in this embodiment is a first rib, and the first rib is one or a combination of vertical edges, horizontal edges, oblique edges, and spiral edges. It should be understood that the shape of the first ridge is not intended to limit the present invention, and other frictional structures that can increase the frictional force between the sampling swab and the inner wall of the first cavity 11 to improve the elution effect of the sampling swab can be applied to the present invention.

The first rib of the present embodiment may preferably be a vertical rib, but the first rib is preferably provided as a vertical rib for the convenience of demolding the tube body 1, and is not intended to limit the present invention.

In addition, the number of the first ribs of the present embodiment can be set to 8-12, which uniformly surround the inner wall of the first cavity 11. It should be noted that the number of the first ribs is not limited to the present invention, and the number of the first ribs in this embodiment can be increased or decreased according to the thickness of the first ribs, the elution effect of the first ribs, and the structural parameters of the sampling swab.

EXAMPLE six

The present embodiment is a sixth embodiment of a storage tube for a primary sampling swab screen, and is the same as the second embodiment, except that a plurality of first protrusions are disposed on the inner wall of the first cavity 11 instead of a continuous structure similar to the first ribs in the second embodiment, which can achieve a better elution effect and save the amount of raw materials for preparing the tube body 1 compared to the second embodiment.

The first salient points in the embodiment can be connected to form one or a combination of a plurality of vertical edge structures, transverse edge structures, oblique edge structures and spiral edge structures, and can also be processed to form irregular edge structures according to requirements. In addition, the shape of the first salient point of the present embodiment may be a hemispherical shape, a square shape, or a friction structure that can increase the friction force between the sampling swab and the first cavity 11 when the sampling swab moves up and down or rotates.

In order to facilitate the processing of the first protrusion 16 and the demolding of the first protrusion 16, the first protrusions of the present embodiment may form a vertical rib structure uniformly surrounding the inner wall of the first cavity 11.

EXAMPLE seven

Fig. 7 to 8 show a seventh embodiment of a storage tube for a sampling swab prescreening of the present invention, which is the same as the fifth or sixth embodiment except that: when sampling the swab, the sample nucleic acid is not only adhered to the side of the sampling swab, but also adhered to the bottom of the sampling swab, and in this embodiment, in addition to the first protrusion 16 surrounding the side wall of the first cavity 11, the second protrusion 17 is further disposed at the bottom inside the first cavity 11, so that the sample nucleic acid at the side of the sampling swab and the sample nucleic acid at the bottom of the sampling swab can be eluted. Specifically, the second protrusion 17 of the present embodiment is a second rib, one end of the second rib is disposed at the bottom center of the first cavity 11, and the other end of the second rib is connected to the first protrusion 16. When the first convex part 16 is the first convex edge and is a vertical edge, the number of the second convex edges is equal to that of the first convex edges, and the first convex edges and the second convex edges can be connected to form an integrated edge-shaped structure. It should be noted that, in the present embodiment, the structure and the number of the second ribs are preferably designed for aesthetic design and convenient processing, and are not limited to the present invention, and other rib structures and the number of ribs capable of achieving the washing-off effect can also be applied to the present invention.

Example eight

This embodiment is an eighth embodiment of the storage tube for a sampling swab prescreening of the present invention, and is the same as the fifth embodiment or the sixth embodiment, except that the first protrusion 16 is circumferentially provided on the sidewall of the first cavity 11, and a second protrusion 17 is further provided on the bottom inside the first cavity 11. The second protrusion 17 of this embodiment is a second protrusion, instead of the continuous structure similar to the second rib of the fourth embodiment, and this embodiment can obtain better elution effect and save the amount of raw materials for preparing the tube 1 compared to the fourth embodiment. The second salient points in the embodiment can be connected to form a regular arrangement structure, and can also be processed to form an irregular edge structure as required. In addition, the shape of the second salient point of the present embodiment may be a hemispherical shape, a square body, or a friction structure that can increase the friction between the sampling swab and the first cavity 11 when the sampling swab moves up and down or rotates.

It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. It will be apparent to those skilled in the art that other variations and modifications can be made on the basis of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.

Claims

1. The utility model provides a sampling swab is preservation pipe for prescreening, is including dismantling body (1) and tube cap (2) of connection, its characterized in that, be equipped with the first cavity (11) that the multiunit is used for placing the sampling swab in body (1) and multiunit first cavity (11) evenly encircle the intercommunication setting, multiunit flow between first cavity (11) has sample release agent, the central axis of first cavity (11) deviate from in the central axis of body (1).

2. The storage tube for sampling swab prescreening of claim 1, wherein a support column (3) is disposed at the center of the interior of the tube body (1), and a plurality of groups of the first cavities (11) are uniformly surrounded between the support column (3) and the inner wall of the tube body (1).

3. A storage tube for sampling swab prescreening according to claim 2, wherein the height of the support column (3) is lower than the height of the first cavities (11), and a second cavity (12) for detecting samples is formed at the connection between the upper part of the support column (3) and each of the first cavities (11).

4. The storage tube for sampling swab prescreening of claim 2, wherein the first cavity (11) is a cylindrical hole, and the wall surface of the cylindrical hole is tangential to the inner wall surface of the tube body (1) and is overlapped with part of the outer wall surface of the support column (3).

5. The storage tube for sampling swab prescreening of claim 1, wherein the top of the tube body (1) is provided with a first connecting portion (13) for connecting the tube cover (2), and the bottom of the tube body (1) is provided with a fixing portion (14).

6. The storage tube for sampling swab prescreening of claim 1, wherein the top of the first cavities (11) is connected with a second connecting part (15), and the second connecting part (15) surrounds between the outer edge of the top of the first cavity (11) and the inner wall of the tube body (1).

7. A storage tube for a sampling swab prescreen according to any one of claims 1 to 6, wherein the inner wall of the first cavity (11) is provided with a plurality of first protrusions (16).

8. The storage tube for sampling swab prescreening of claim 7, wherein the first protrusion (16) is a first rib or a first protrusion, and the first rib is one or a combination of vertical ribs, horizontal ribs, inclined ribs and spiral ribs.

9. A storage tube for a sampling swab prescreen as claimed in claim 7, wherein the first cavity (11) has a plurality of second protrusions (17) uniformly distributed on the bottom of the inner side.

10. A sample swab prescreening storage tube according to claim 9, wherein the second protrusion (17) is a second rib or a second protrusion, one end of the second rib is arranged at the center of the bottom of the first cavity (11), and the other end of the second rib is connected to the first protrusion (16).