CN112807406A

CN112807406A - Preparation for treating dysmenorrhea and preparation method thereof

Info

Publication number: CN112807406A
Application number: CN202110209468.1A
Authority: CN
Inventors: 高广志
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-02-24
Filing date: 2021-02-24
Publication date: 2021-05-18

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and discloses a preparation for treating dysmenorrhea and a preparation method thereof. The preparation is prepared by selecting the salvia miltiorrhiza and the rhizoma cyperi as monarch drugs, and is used for regulating qi, resolving depression, promoting tissue regeneration and activating blood; the angelica tail, the trogopterus dung and the peach kernel are selected as ministerial drugs for breaking blood, promoting blood circulation, removing blood stasis and easing pain; cortex moutan, radix Curcumae, fructus Gardeniae, and Olibanum are used as adjuvant drugs for clearing heat, promoting blood circulation, cooling blood, and removing blood stasis; safflower and radix bupleuri are selected as adjuvant drugs and used for matching with monarch drug to further achieve the purposes of activating blood and promoting blood circulation, soothing liver and regulating qi, and regulating menstruation and relieving pain; rhizoma Ligustici Chuanxiong, herba Lycopi and Glycyrrhrizae radix are used as guiding drugs for promoting qi circulation, resolving stagnation, promoting blood circulation and relieving pain. The preparation has effects of warming uterus, promoting blood circulation, removing blood stasis, eliminating dampness, dispelling cold, relieving swelling, removing blood stasis, relieving pain, activating qi-flowing, resolving stagnation, nourishing yin, moistening dryness, invigorating yang, and warming middle-jiao by mutual fusion and interaction of monarch, minister, assistant and guide. The preparation method has simple flow, can effectively and fully release and exert the pharmaceutical ingredients, has no toxic or side effect, is safe and reliable, and is suitable for large-scale production.

Description

Preparation for treating dysmenorrhea and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a preparation for treating dysmenorrhea and a preparation method thereof.

Background

Dysmenorrhea is a common and frequently encountered gynecological disease, has multiple causes, complex pathogenesis and large repeatability, is delicate in treatment, is particularly more common for young unbelided women and young girls in the early menstrual period, and is characterized in that lower abdominal distending pain, cold pain, burning pain, stabbing pain, dull pain, falling pain, angina, spastic pain and tearing pain periodically occur in the menstrual period or before and after menstruation, the pain extends to the sacral waist and back, even the upper legs and the feet are involved, and the general symptoms are often accompanied: distending pain of breast, anal pendant expansion, chest distress, dysphoria, sadness, irritability, heart convulsion, insomnia, headache, dizziness, nausea, emesis, stomach ache, diarrhea, listlessness, debilitation, pale complexion, cold limbs, cold sweat, syncope, etc. The disease is high, the range is wide, the period is short, the pain is great, the work and the study of women are seriously influenced, and the life quality is reduced.

In the field of traditional Chinese medicine, dysmenorrhea is differentiated into five syndrome types: qi stagnation and blood stasis, cold-dampness stagnation, damp-heat stagnation, deficiency of both qi and blood, and deficiency of liver and kidney. In the field of western medicine, dysmenorrhea is classified into "primary" and "secondary". Primary dysmenorrhea refers to the condition of no obvious organic lesions in the reproductive organs after gynecological examination, and is usually caused by young adolescents in adolescence or born young women 2-3 years after the first tide of menstruation. The secondary dysmenorrhea is caused by the pelvic inflammation, the uterine tumor and the endometriosis lesion of the reproductive organ with obvious organic lesion through the technical examination of gynecology, B-type ultrasonic imaging, laparoscope and the like.

At present, dysmenorrhea has no exact objective index on diagnosis, and can be diagnosed and treated only according to chief complaints and expressed symptoms of patients. In order to prevent the onset of dysmenorrhea, western medicine can orally take spasmolytic and analgesic medicines 12-24 hours before menstrual period or treat the dysmenorrhea through endocrine (common medicines comprise estrogen medicines, progestational medicines, contraceptives and prostatic antagonistic medicines). The dysmenorrhea can also be treated by the methods of expanding the diameter of uterine ligament capillaries, increasing the intersection point of capillary vessel network and accelerating the blood flow speed, thereby improving the microcirculation function of the uterus, relieving the spastic contraction of uterine smooth muscle, reducing the content of menstrual prostaglandin PCF2a and regulating endocrine, but the method is easy to generate repetition and can only temporarily relieve the symptoms of the dysmenorrhea. According to the traditional Chinese medicine, dysmenorrhea is treated by soothing the liver and relieving depression, dredging the channels, promoting blood circulation to remove blood stasis, and regulating qi to alleviate pain, but the medicines are generally required to be manually mixed and applied for external use, so that the using method is complicated and inconvenient. Patient compliance is poor. The partially used external patch or navel patch often has low absorption performance, and the use time is obviously prolonged.

Disclosure of Invention

In order to solve the above problems in the prior art, the present invention aims to provide a preparation for treating dysmenorrhea and a preparation method thereof.

The technical scheme adopted by the invention is as follows: the preparation for treating dysmenorrhea is mainly prepared from the following raw materials in parts by mass:

8-60 parts of angelica tail, 4-22 parts of ligusticum wallichii, 20-120 parts of rhizoma cyperi, 5-50 parts of trogopterus dung, 5-50 parts of moutan bark, 7-33 parts of radix curcumae, 7-33 parts of gardenia, 7-33 parts of frankincense, 5-50 parts of herba lycopi, 15-65 parts of peach kernel, 3-21 parts of safflower, 7-33 parts of radix bupleuri, 20-120 parts of salvia miltiorrhiza and 3-21 parts of liquorice.

The invention provides a preparation for treating dysmenorrhea, which is prepared by selecting salvia miltiorrhiza and rhizoma cyperi as monarch drugs and is used for regulating qi, resolving depression, promoting tissue regeneration and activating blood; the angelica tail, the trogopterus dung and the peach kernel are selected as ministerial drugs for breaking blood, promoting blood circulation, removing blood stasis and easing pain; cortex moutan, radix Curcumae, fructus Gardeniae, and Olibanum are used as adjuvant drugs for clearing heat, promoting blood circulation, cooling blood, and removing blood stasis; safflower and radix bupleuri are selected as adjuvant drugs and used for matching with monarch drug to further achieve the purposes of activating blood and promoting blood circulation, soothing liver and regulating qi, and regulating menstruation and relieving pain; rhizoma Ligustici Chuanxiong, herba Lycopi and Glycyrrhrizae radix are used as guiding drugs for promoting qi circulation, resolving stagnation, promoting blood circulation and relieving pain. The preparation has effects of warming uterus, promoting blood circulation, removing blood stasis, eliminating dampness, dispelling cold, relieving swelling, removing blood stasis, relieving pain, activating qi-flowing, resolving stagnation, nourishing yin, moistening dryness, invigorating yang, and warming middle-jiao by mutual fusion and interaction of monarch, minister, assistant and guide.

Preferably, the preparation is mainly prepared from the following raw materials in parts by mass:

20-40 parts of angelica tail, 10-18 parts of ligusticum wallichii, 40-80 parts of rhizoma cyperi, 15-38 parts of trogopterus dung, 15-38 parts of moutan bark, 10-25 parts of radix curcumae, 10-25 parts of gardenia, 10-25 parts of frankincense, 15-38 parts of herba lycopi, 20-50 parts of peach kernel, 7-17 parts of safflower, 10-25 parts of radix bupleuri, 40-80 parts of salvia miltiorrhiza and 7-17 parts of liquorice.

25 parts of angelica tail, 12 parts of ligusticum wallichii, 50 parts of rhizoma cyperi, 20 parts of trogopterus dung, 20 parts of moutan bark, 15 parts of radix curcumae, 15 parts of cape jasmine, 15 parts of frankincense, 20 parts of herba lycopi, 30 parts of peach kernel, 10 parts of safflower carthamus, 15 parts of radix bupleuri, 50 parts of salvia miltiorrhiza and 10 parts of liquorice.

The angelica tail promotes blood circulation to remove blood stasis. The application comprises the following steps: amenorrhea, blood stasis, stagnation and swelling and pain. The Dang Gui is mainly to activate and break blood.

Chuanxiong rhizome, the name: ligusticum chuanxiong Hort, a cultivated plant, is a traditional Chinese medicine plant, is commonly used for promoting blood circulation and promoting qi circulation, dispelling pathogenic wind and relieving pain, and Ligusticum wallichii is pungent, warm, fragrant and dry, walks but not on, can walk scattered, and can ascend to the vertex of the mountain; it enters the blood system and goes down to reach the blood sea. Promoting blood circulation and removing blood stasis, and is suitable for various diseases caused by blood stasis; it has good effect in dispelling pathogenic wind and relieving pain, and can be used for treating headache, rheumatalgia, etc. Warm in nature and pungent in flavor. It enters liver and gallbladder meridians. Move qi and relieve depression, dispel wind-dryness and dampness, activate blood and alleviate pain. It is indicated for headache, dizziness, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, postpartum stasis, pain due to stagnation of qi, superficial infection, sores and ulcers. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia.

Cyperus rotundus (Cyperus rotundus) with name of Cyperus rotundus and Cyperus rotundus. The flavor is pungent, slightly bitter and sweet, and mild in nature. Enter liver and triple energizer meridians. Regulating qi-flowing, resolving stagnation, regulating menstruation and relieving pain. Can be used for treating stagnation of qi due to depression of the liver, distending pain of chest, hypochondrium, and abdomen, dyspepsia, menoxenia, amenorrhea, dysmenorrhea, cold hernia, abdominal pain, and breast pain.

Oletum Trogopterori, named as Chinese medicinal material. The product is dry feces of petriomys auratus and flying squirrel. Collected all the year round. The main functional indications are as follows: unprocessed with the effect of promoting blood circulation to alleviate pain. Treating pain due to blood and qi in heart and abdomen, amenorrhea, and puerperal pain due to blood stasis; it can be used for treating snake bite, scorpion bite, and centipede bite. Stir-baked for stopping bleeding. It is indicated for metrorrhagia, menorrhagia and metrostaxis. Sweet, warm and nontoxic. Enter liver and spleen meridians. It is good at breaking blood and moving blood, so it is indicated for pain due to stasis, postpartum blood fainting, aversion to blood rushing to heart, lower abdomen and occipital pain, amenorrhea due to retention of blood, pain between heart and stomach due to stasis, blood stasis in channels and collaterals, failure of qi to move, and pain due to thorns.

Cortex moutan is also known as cortex moutan, cortex moutan radicis, Paeonia lactiflora pall, cortex moutan radicis, and flos luoyang. The product is dried root bark of Paeonia suffruticosa Andr. The inner surface is pale grayish yellow or light brown, has obvious fine longitudinal lines and is often brightly crystallized. Hard and brittle, easy to break, flat section, light pink, and powdery. Fragrant smell, slightly bitter and astringent taste. Bitter, pungent and slightly cold. It enters heart, liver and kidney meridians. Clear heat and cool blood, activate blood and resolve stasis. Can be used for treating toxic heat, speckle, hematemesis, epistaxis, nocturnal fever, morning cool, anhidrosis, amenorrhea, dysmenorrhea, carbuncle, swelling, sore, traumatic injury, and pain. Moutan bark, cortex moutan has the effects of cooling blood and dissipating blood stasis because it excels in clearing blood and activating blood, so that blood can flow smoothly without retaining blood stasis, and blood heat can be cleared without bleeding. So it can be used for treating blood heat exuberance, liver and kidney fire hyperactivity, and blood stasis. Can be used for treating amenorrhea, traumatic injury, skin ulcer, carbuncle, toxic swelling, and intestinal carbuncle. Amenorrhea and injury are accompanied by stagnation of qi and blood, and pain often occurs due to obstruction of the meridians. The root bark of peony tree has the effects of activating blood and dissolving stasis, so that stasis is dispersed and qi and blood are smooth, and pain is relieved.

Yu jin, the name of Chinese medicine. Is dried root tuber of Curcuma wenyuma Curcuma wenyujin Y, H.Chenet C.Ling, Curcuma longa LongaL, Curcuma kwangmakuwangsiensis S.G.Lee et C.F.Liang or Curcuma zedoaria Curcuma phaeocauli Val. Pungent and bitter taste and cool in nature. Enter heart, lung and liver meridians. Move qi and relieve depression, cool blood and break blood stasis. It is indicated for pain in chest, abdomen and hypochondrium, mania due to loss of heart, coma due to fever, hematemesis, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, and jaundice. Governing blood accumulation, descending qi, promoting granulation, stopping bleeding, breaking blood stasis, stranguria with blood, hematuria and incised wound.

A method for preparing parched fructus Gardeniae comprises parching clean fructus Gardeniae to brown. Fruit: purging fire, relieving restlessness, clearing heat, inducing diuresis, cooling blood and removing toxicity. Can be used for treating vexation due to fever, jaundice, dark urine, stranguria with blood, pain, hematemesis, epistaxis, conjunctival congestion, swelling and pain, and pyocutaneous disease due to pathogenic fire; it can be used for treating sprain, contusion and pain. Root: purging fire and removing toxicity, clearing heat and promoting diuresis, cooling blood and dissipating blood stasis. Can be used for treating infectious hepatitis, traumatic injury, and toothache due to pathogenic wind-fire.

Frankincense, name of traditional Chinese medicine. Is resin exuded from bark of Boswellia carterii Birdw of Boswellia carterii of Burseraceae and Boswellia bhauradea Birdw of the same genus. Pungent, bitter and warm in nature. Enter heart, liver and spleen meridians. Promote blood circulation, move qi and alleviate pain. It is indicated for abdominal pain, arthralgia due to wind-dampness, traumatic injury, dysmenorrhea and postpartum abdominal pain due to stagnation of qi.

Herba Lycopi, also known as Gekko Swinhonis, rhizoma Lycopi, herba Stachydis Japonicae, and herba Potentillae Discoloris, and Latin Wenyujin is called Eupatorium japonica Thunb. Has effects of promoting blood circulation, regulating menstruation, removing blood stasis, resolving carbuncle, inducing diuresis, and relieving swelling. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, puerperal blood stasis and abdominal pain, skin ulcer, carbuncle, toxic swelling, edema, and ascites. Bitter and pungent taste, slightly warm in nature; it enters liver and spleen meridians. Herba Lycopi can improve microcirculation disturbance, accelerate blood flow in capillary, and expand capillary diameter.

Peach kernel, name of traditional Chinese medicine. Is dried mature seed of Prunus persica (L.) Batsch or Prunus davidiana (Carr.) Franch, Rosaceae. Has the effects of promoting blood circulation, removing blood stasis, loosening bowel to relieve constipation, and relieving cough and asthma. Can be used for treating amenorrhea, dysmenorrhea, abdominal mass, pulmonary abscess, intestinal carbuncle, traumatic injury, intestinal dryness, constipation, cough, and asthma. Peach kernel has strong blood stasis dispelling effect and can relieve blood stasis, and the alcohol extract of peach kernel can obviously increase cerebral blood flow, reduce vascular resistance and improve the hemodynamic status, so peach kernel is also called blood breaker and can be used for treating various blood stasis and retardation diseases, such as blood stasis and amenorrhea, dysmenorrhea, postpartum blood stasis and abdominal pain, traumatic injury, swelling and pain, pulmonary abscess, intestinal abscess and the like. The water decoction and extract of semen Persicae also has analgesic, antiinflammatory, antibacterial, and antiallergic effects. Bitter taste and mild nature.

Safflower, (Latin scientific name: Carthamus tinctorius L.), alias: carthamus tinctorius flower, Compositae, Carthamus plant, and dried tubular flower. Has special fragrance and slightly bitter taste. Promoting blood circulation, dredging channels, removing blood stasis, and relieving pain, and can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, thoracic obstruction, cardialgia, blood stasis, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, and pyocutaneous disease with swelling and pain. Has the effects of promoting blood circulation, removing blood stasis, eliminating dampness and swelling, and can be used for preventing pregnant women from abortion. It is warm in nature and pungent in flavor, and enters heart and liver meridians. Promoting blood circulation, moistening dryness, relieving pain, relieving swelling, and dredging channels.

Bupleurum root, the name of Chinese medicine. Is dried root of Bupleurum chinense DC or Bupleurum scorzonerifolium Willd. Has the effects of relieving exterior syndrome, relieving fever, dispersing stagnated liver qi for relieving qi stagnation, and lifting yang qi. It is mainly used for treating exterior syndrome fever, shaoyang syndrome, liver depression and qi stagnation, qi deficiency sinking, organ prolapse, fever abatement and malaria interception. Bupleuri radix has effects of tranquilizing, calming, relieving pain, relieving fever, and relieving cough. Bupleuri radix and its effective component saikoside have anti-inflammatory effect, and the anti-inflammatory effect is related to promoting adrenal cortex system function. Saikosaponin also has effect of reducing blood plasma cholesterol. Radix bupleuri has good effects of resisting fatty liver, resisting liver injury, promoting bile flow, reducing transaminase, exciting smooth muscle of intestine, inhibiting gastric acid secretion, resisting ulcer, inhibiting trypsin, etc. The bupleuri radix decoction has effect in inhibiting tubercle bacillus. In addition, bupleuri radix has effects of resisting common cold virus, increasing protein biosynthesis, resisting tumor, resisting radiation, and enhancing immunity.

Salvia miltiorrhiza (with the scientific name of Salvia millirrhiza Bunge) is used as a medicine, contains tanshinone, is a strong menstrual flow stimulating agent, has the effects of removing blood stasis, promoting tissue regeneration, promoting blood circulation, regulating menstruation and the like, is a key medicine for gynecology, and is mainly used for treating metrorrhagia, irregular menstruation, blood stasis, abdominal pain, menstrual pain, amenorrhea and temple pain. Has good effect on treating coronary heart disease. In addition, the medicine also can be used for treating insomnia caused by neurasthenia, arthralgia, anemia, mastitis, lymphadenitis, arthritis, sore and furuncle pain and swelling, erysipelas, acute and chronic hepatitis, kidney menyan nephritis, traumatic injury, liver and spleen swelling caused by late schistosomiasis, and epilepsy 30286.

Licorice, academic name: glycyrrhiza uralensis Fisch. Light smell, sweet and special taste. The functions are mainly used for clearing away heat and toxic material, eliminating phlegm and relieving cough, and treating abdominal cavity and the like.

Preferably, the formulation is an oral formulation.

A preparation method of a preparation for treating dysmenorrhea comprises the steps of selecting gardenia according to a corresponding proportion, frying, mixing and crushing the gardenia with angelica tail, ligusticum wallichii, rhizoma cyperi, trogopterus dung, moutan bark, radix curcumae, frankincense, herba lycopi, peach kernel, safflower, radix bupleuri, salvia miltiorrhiza and liquorice, and adding a solid forming agent to obtain a finished product.

The preparation method of the preparation has simple process, can effectively and fully release and exert the pharmaceutical ingredients, promotes the absorption of the ingredients, has no toxic or side effect, is safe and reliable, and is suitable for large-scale production.

Preferably, when the gardenia is selected for stir-frying, the stir-frying temperature is 80-100 ℃.

Preferably, when the gardenia is selected to be fried, the gardenia is fried for 3 to 5 minutes.

Preferably, the gardenia is selected according to the corresponding proportion and fried, and then mixed and crushed with angelica tail, ligusticum wallichii, rhizoma cyperi, trogopterus dung, moutan bark, radix curcumae, frankincense, herba lycopi, peach kernel, safflower, radix bupleuri, salvia miltiorrhiza and liquorice, and the particle size of the crushed powder is 100 meshes and 300 meshes.

Preferably, the solid agent is honey and/or water.

Preferably, the mass ratio of the fried gardenia to the total mass of the angelica tail, the ligusticum wallichii, the rhizoma cyperi, the trogopterus dung, the moutan bark, the radix curcumae, the frankincense, the herba lycopi, the peach kernel, the safflower, the radix bupleuri, the salvia miltiorrhiza and the liquorice to the solid preparation is 1-2: 8-12.

The preparation adopts a solid form in the preparation process, and the solid form is a traditional Chinese medicine preparation form, so that the preparation has the characteristics of obvious positioning and less adverse reaction. And the solid preparation has high applicability in the aspects of storage mode, storage time and the like.

The invention has the beneficial effects that:

Detailed Description

The present invention is further illustrated below with reference to specific examples. It will be appreciated by those skilled in the art that the following examples, which are set forth to illustrate the present invention, are intended to be part of the present invention, but not to be construed as limiting the scope of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. The examples were carried out under the conventional conditions, unless otherwise specified. The reagents used are all conventional products which are commercially available.

Example 1:

a preparation method of a preparation for treating dysmenorrhea comprises selecting 70 g of cape jasmine according to a corresponding proportion, frying for 3 minutes at 80 ℃, mixing with 80 g of angelica tail, 40 g of ligusticum wallichii, 200 g of rhizoma cyperi, 50 g of trogopterus dung, 50 g of moutan bark, 70 g of radix curcumae, 70 g of frankincense, 50 g of herba lycopi, 150 g of peach kernel, 30 g of safflower, 70 g of radix bupleuri, 200 g of salvia miltiorrhiza and 30 g of liquorice, crushing, sieving with a 100-mesh sieve, and adding 784 g of water to obtain a finished product.

Example 2:

a preparation method of a preparation for treating dysmenorrhea comprises selecting 70 g of cape jasmine according to a corresponding proportion, frying for 5 minutes at 100 ℃, mixing with 80 g of angelica tail, 40 g of ligusticum wallichii, 200 g of rhizoma cyperi, 50 g of trogopterus dung, 50 g of moutan bark, 70 g of radix curcumae, 70 g of frankincense, 50 g of herba lycopi, 150 g of peach kernel, 30 g of safflower, 70 g of radix bupleuri, 200 g of salvia miltiorrhiza and 30 g of liquorice, crushing, sieving with a 300-mesh sieve, and adding 1470 g of honey to obtain a finished product.

Example 3:

a preparation method of a preparation for treating dysmenorrhea comprises selecting 330 g of cape jasmine according to a corresponding proportion, frying for 5 minutes at 100 ℃, mixing with 600 g of angelica tail, 220 g of ligusticum wallichii, 1200 g of rhizoma cyperi, 500 g of trogopterus dung, 500 g of moutan bark, 330 g of radix curcumae, 330 g of frankincense, 500 g of herba lycopi, 650 g of peach kernel, 210 g of safflower, 330 g of radix bupleuri, 1200 g of salvia miltiorrhiza and 210 g of liquorice, crushing, sieving with a 300-mesh sieve, and adding 9045 g of honey to obtain a finished product.

The honey used in the above embodiment is refined honey, which is obtained by heating honey to above 119 deg.C to evaporate water sufficiently, and has reddish brown bubbles, luster, sticky twist and white thread. The purpose of refining honey is to remove impurities, destroy enzymes, kill microorganisms, evaporate water and enhance viscosity.

Example 4:

a preparation method of a preparation for treating dysmenorrhea comprises selecting 330 g of cape jasmine according to a corresponding proportion, frying for 3 minutes at 80 ℃, mixing with 600 g of angelica tail, 220 g of ligusticum wallichii, 1200 g of rhizoma cyperi, 500 g of trogopterus dung, 500 g of moutan bark, 330 g of radix curcumae, 330 g of frankincense, 500 g of herba lycopi, 650 g of peach kernel, 210 g of safflower, 330 g of radix bupleuri, 1200 g of salvia miltiorrhiza and 210 g of liquorice, crushing, sieving with a 100-mesh sieve, and adding 48240 g of water to obtain a finished product.

Example 5:

a preparation method of a preparation for treating dysmenorrhea comprises selecting 100 g of cape jasmine according to a corresponding proportion, frying for 3 minutes at 80 ℃, mixing with 200 g of angelica tail, 100 g of ligusticum wallichii, 400 g of rhizoma cyperi, 150 g of trogopterus dung, 150 g of moutan bark, 100 g of radix curcumae, 100 g of frankincense, 150 g of herba lycopi, 200 g of peach kernel, 70 g of safflower, 100 g of radix bupleuri, 400 g of salvia miltiorrhiza and 70 g of liquorice, crushing, sieving with a 100-mesh sieve, and adding 18320 g of water to obtain a finished product.

Example 6:

a preparation method of a preparation for treating dysmenorrhea comprises selecting 100 g of cape jasmine according to a corresponding proportion, frying for 5 minutes at 100 ℃, mixing with 200 g of angelica tail, 100 g of ligusticum wallichii, 400 g of rhizoma cyperi, 150 g of trogopterus dung, 150 g of moutan bark, 100 g of radix curcumae, 100 g of frankincense, 150 g of herba lycopi, 200 g of peach kernel, 70 g of safflower, 100 g of radix bupleuri, 400 g of salvia miltiorrhiza and 70 g of liquorice, crushing, sieving with a 100-mesh sieve, and adding 3435 g of honey to obtain a finished product.

Example 7:

a preparation method of a preparation for treating dysmenorrhea comprises selecting 250 g of cape jasmine according to a corresponding proportion, frying for 3 minutes at 80 ℃, mixing with 400 g of angelica tail, 180 g of ligusticum wallichii, 800 g of rhizoma cyperi, 380 g of trogopterus dung, 380 g of moutan bark, 250 g of radix curcumae, 250 g of frankincense, 380 g of herba lycopi, 500 g of peach kernel, 170 g of safflower, 250 g of radix bupleuri, 800 g of salvia miltiorrhiza and 170 g of liquorice, crushing, sieving with a 100-mesh sieve, and adding 41280 g of water to obtain a finished product.

Example 8:

a preparation method of a preparation for treating dysmenorrhea comprises selecting 250 g of cape jasmine according to a corresponding proportion, frying for 3 minutes at 100 ℃, mixing with 400 g of angelica tail, 180 g of ligusticum wallichii, 800 g of rhizoma cyperi, 380 g of trogopterus dung, 380 g of moutan bark, 250 g of radix curcumae, 250 g of frankincense, 380 g of herba lycopi, 500 g of peach kernel, 170 g of safflower, 250 g of radix bupleuri, 800 g of salvia miltiorrhiza and 170 g of liquorice, crushing, sieving with a 100-mesh sieve, and adding 7740 g of honey to obtain a finished product.

Example 9:

a preparation method of a preparation for treating dysmenorrhea comprises selecting 150 g of cape jasmine according to a corresponding proportion, frying for 5 minutes at 80 ℃, mixing with 250 g of angelica tail, 120 g of ligusticum wallichii, 500 g of rhizoma cyperi, 200 g of trogopterus dung, 200 g of moutan bark, 150 g of radix curcumae, 150 g of frankincense, 200 g of herba lycopi, 300 g of peach kernel, 100 g of safflower, 150 g of radix bupleuri, 500 g of salvia miltiorrhiza and 100 g of liquorice, crushing, sieving with a 100-mesh sieve, and adding 2460 g of water to obtain a finished product.

Example 10:

a preparation method of a preparation for treating dysmenorrhea comprises selecting 150 g of cape jasmine according to a corresponding proportion, frying for 3 minutes at 100 ℃, mixing with 250 g of angelica tail, 120 g of ligusticum wallichii, 500 g of rhizoma cyperi, 200 g of trogopterus dung, 200 g of moutan bark, 150 g of radix curcumae, 150 g of frankincense, 200 g of herba lycopi, 300 g of peach kernel, 100 g of safflower, 150 g of radix bupleuri, 500 g of radix salviae miltiorrhizae and 100 g of liquorice, crushing, sieving with a 300-mesh sieve, and adding 4605 g of honey to obtain a finished product.

In the actual operation process of all the embodiments, the selected blending device comprises a three-dimensional motion mixer, stainless steel materials with specification models of SYH-30 and SYH-1000, and manufacturers: jiangyin and Rong mechanical Co. The selection of the stirring device is not limited to the above, and all devices which can complete the corresponding stirring work and have no influence on raw materials belong to the protection scope of the invention.

In the practical operation process of all the above embodiments, the selected filtering device comprises a microporous membrane filter, a stainless steel material, and the style: tubular, manufacturer: sitepu filtration equipment, Inc., New county. The selection of the filtering device is not limited to the above, and all devices which can complete the corresponding filtering work and have no influence on raw materials belong to the protection scope of the invention.

In the actual operation process of all the embodiments, the selected pulverizer is a Chinese herbal medicine superfine pulverizer, and the type is as follows: JCWF-15A, manufacturer: junchen distance mechanical equipment, Inc. The selection of the type of the pulverizer and the selection of manufacturers can be set according to the actual environment and the actual requirements in the specific implementation process. All the raw materials can be crushed, and the components of the crushed materials are consistent with those of the finished products obtained in the above embodiments after being filtered and sieved, and the method belongs to the protection scope of the invention.

In the practical operation process, the finished product needs to be packaged, and a horizontal packaging machine and an ink-jet printer are respectively selected. The horizontal packaging machine is made of stainless steel, the specification and model are SG-180, and a manufacturer: shanghai plastic packaging science and technology, Inc. The ink jet numbering machine is made of stainless steel, the specification and model are V803-D, and a manufacturer: beijing Oriental Union technologies, Inc.

The pellets prepared in the above examples are recommended to be 0.5 to 0.8 g.

The administration mode is as follows: is orally administered in 5 pills each time, 3 times a day, and 21 days as one treatment course for 2-4 treatment courses.

Examples of the experiments

Subject: randomly selecting patients with symptoms of severe abdominal pain, abdominal distention and rolling pain during menstrual period as experimental subjects, and selecting 110 patients with age of 15-35 years without marriage.

Wherein 10 patients were selected to take the pill as a control group; the remaining 100 patients were used as experimental groups, 10 subjects per group were divided into 10 groups, and numbered: 1-10.

The experimental reagent and the using method are as follows: the finished preparation corresponding to each example is prepared according to the configuration mode of the preparation provided in each example. The finished preparation prepared in each example is orally taken by each group of experimental subjects, 5 pills are taken at a time, 3 times a day and 15 days are taken as a treatment course, and 3 treatment courses are totally treated.

The control group took DINGKUNDAN (widely known as Yuan), 2 times daily, half granule each time. The symptoms of the experimental group and the control group after one treatment course of administration of the corresponding products were observed separately.

The judgment standard of the curative effect is as follows:

the diagnosis standard refers to the diagnosis standard in TCM gynecology. Dysmenorrhea is a faint patient with periodic lower abdominal pain during or before the menstrual period, accompanied by other discomforts such as breast swelling and cold hands and feet, which affect work and life. The gynecological examination of married women and the B-mode ultrasonic examination of unwounded women can eliminate genital organ organic lesions. According to the guidelines of clinical research on new drugs, the dysmenorrhea is classified into light, medium and heavy grades 3 (Ministry of health of the people' S republic of China, guidelines of clinical research on new drugs in Chinese medicine, edition 1 [ S ],1993, 252).

And (3) curing: after 1 course of treatment, no abdominal pain and abdominal distension appear next time.

Improvement: the lower abdomen is severely painful, the abdominal distension is painful, the rolling symptom is obviously improved, and the pain is obviously relieved.

And (4) invalidation: the lower abdomen is severely painful, the abdominal distension is painful, and the rolling symptom is unchanged.

The cure rate is 10 multiplied by 100 percent.

The experimental results are as follows:

the data result shows that the cure rate of the invention in the example 9 and the example 10 reaches 90%. The cure rate of other embodiments is above 40% -50%. Meanwhile, after the experimental treatment course is finished, the experimental subjects of the experimental group do not have any discomfort phenomenon and relapse condition. In the control group, some subjects had recurrence.

While particular embodiments of the present invention have been illustrated and described, it will be appreciated that the present invention is not limited to the above-described alternative embodiments, and that various other forms of product may be devised by anyone in light of the present invention. The foregoing detailed description should not be construed as limiting the scope of the invention, and it will be understood by those skilled in the art that modifications may be made to the technical solutions described in the foregoing embodiments, or that equivalent substitutions may be made to some or all of the technical features thereof, without departing from the spirit and scope of the invention, and that these modifications or substitutions may not substantially depart from the essence of the corresponding technical solutions.

Claims

1. The preparation for treating dysmenorrhea is characterized by being prepared from the following raw materials in parts by mass:

2. The preparation for treating dysmenorrhea according to claim 1, wherein the preparation is prepared from the following raw materials in parts by mass:

3. The preparation for treating dysmenorrhea according to claim 2, wherein the preparation is prepared from the following raw materials in parts by mass:

4. A formulation for the treatment of dysmenorrhea according to any one of claims 1 to 3, wherein said formulation is an oral formulation.

5. The method for preparing a preparation for treating dysmenorrhea according to any one of claims 1 to 3, wherein the preparation method comprises selecting fructus Gardeniae according to corresponding proportion, parching, mixing with radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, rhizoma Cyperi, Oletum Trogopterori, cortex moutan, radix Curcumae, Olibanum, herba Lycopi, semen Persicae, Carthami flos, bupleuri radix, Saviae Miltiorrhizae radix and Glycyrrhrizae radix, pulverizing, and adding solid agent to obtain the final product.

6. The method for preparing a preparation for treating dysmenorrhea according to claim 5, wherein the temperature of parching fructus Gardeniae is 80-100 deg.C.

7. The method for preparing a preparation for treating dysmenorrhea according to claim 5, wherein said selecting gardenia jasminoides ellis is stir-fried for 3-5 minutes.

8. The method for preparing a preparation for treating dysmenorrhea according to claim 5, wherein said Gardenia jasminoides is selected according to the corresponding ratio, and is fried, and then mixed with Angelica sinensis, Ligusticum wallichii, Cyperus rotundus, Oletum Trogopterori, moutan bark, Curcuma aromatica, Olibanum, herba Lycopi, semen Persicae, Carthami flos, bupleuri radix, Saviae Miltiorrhizae radix and Glycyrrhrizae radix, and pulverized, and the particle size of the pulverized powder is 100-300 mesh.

9. The method for preparing a preparation for treating dysmenorrhea according to claim 5, wherein said solid agent is honey and/or water.

10. The method for preparing a preparation for treating dysmenorrhea according to claim 5, wherein the mass ratio of the fried gardenia to the total mass of the angelica sinensis, the ligusticum wallichii, the rhizoma cyperi, the trogopterus dung, the moutan bark, the radix curcumae, the frankincense, the herba lycopi, the peach kernel, the safflower, the radix bupleuri, the salvia miltiorrhiza and the liquorice to the solid preparation is 1-2: 8-12.