CN1127965C - Chinese medicine 'Sanrupi' for treating mastoplasia - Google Patents

Abstract

The present invention relates to an oral liquid for dispersing lumps in the breast, which is a traditional Chinese medicine preparation for treating cyclomastopathy and comprises effective components of seven traditional Chinese medicines: trichosanthes, dried green orange peel, pedate pinallia jackinthepulpit rhizome, barbat skullcap, fructus toosendan, wild chrysanthemum and nutgrass galingale rhizome. The preparation method for the oral liquid comprises: concentrated liquid medicine is obtained with a conventional traditional Chinese medicine preparation method, and then, ethanol is added to the liquid medicine to be stirred and obtain precipitation through centrifugal separation, ethanol is recovered from supernatant fluid through decompression, and finally, the effective components are obtained.

Description

A kind of Chinese medicine preparation for the treatment of cyclomastopathy

The present invention relates to a kind of Chinese medicine preparation, particularly relate to a kind of Chinese medicine preparation that is used for the treatment of cyclomastopathy---the nodules of the breast oral liquid looses.

Cyclomastopathy belongs to the category of motherland's Chinese medicine " addiction disease ", and motherland's Chinese medicine sees Huatuo's " Huatuo's Zhongzang classic " (twoth century of Christian era Chinese end) to the record beginning of nodules of the breast.That western medicine is described the earliest to primary disease is British cooper in 1845.Surplus the title of primary disease has ten more than the kind, as the bad disease of mammary structure, cystic hyperplasia of breast, cyclomastopathy, adenosis of breast or the like.National tumor in 1972 prevents doing to name being cyclomastopathy.

Cyclomastopathy is the modal disease of numerous women, accounts for 70% of woman mammary gland disease.Along with the raising of people's material and culture life, the patient of prescription on individual diagnosis is more and more, so primary disease also is referred to as modern disease.China more than 30 years old the ill opportunity of women be more than 50%.Primary disease belongs to the non-neoplastic lesion of non-inflammatory, with leaflet structure quantitatively with modal unusually serve as main change, be characterized in the mammary structure disorder that physiological hypertrophy and subinvolution cause.Divide simple property cyclomastopathy and capsule cyclomastopathy two stages clinically; The former is the commitment of pathological changes, is distinguishing feature with breast periodicity pain, and disease changes slight, and the latter is the cyclomastopathy phase, and cyclomastopathy mainly refers to this phase, and 10% patient does not have breast pain, has pain regular unlike the former yet.Typical sign is mammary gland limit office property or diffuse thickening or the capsule reality tuberosity that differs in size.The main cause of primary disease morbidity is considered to the ovary endocrine disturbance.Motherland's medical science is thought the generation of cyclomastopathy and liver, stomach, closely related towards conception vessel, and is often not smooth because of depression of liver-QI, feelings, takes advantage of spleen to violate stomach." its nuclear is growth and decline with susceptible to anger." appoint towards uncomfortable, distending pain of the breast personal attendant menstrual cycle and change.

Why cyclomastopathy is paid attention to by people, and the one, the sickness rate height, the 2nd, generally be considered to belong to precancerosis, canceration rate exceeds 18 times of 4 ￣ than the normal person.Up to now primary disease still there is not a kind of especially effectively Therapeutic Method.According to the sexual hormone disturbance theory, the external scheme that suppresses the estrogen Drug therapy that always adopts.The minority case is taked operative treatment.Domestic medical treatment adopts methyl testosterone, Progesterone, vitamin medicaments, 5% liquor kalii iodide, bromocriptine, treats with tamoxifen since 1980.More than the medicine kind not affirming with the explanation therapeutic effect.Principle according to determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs.The Chinese traditional treatment cyclomastopathy has its distinctive feature, is the main means of domestic present treatment primary disease.Reinstate eliminating stagnation spirit, ease pill, XIAOJIN DAN treatment cyclomastopathy the sixties, continue into the present.RUKUAIXIAO, RUPIXIAO appear again in recent years, the stifled soup that disappears, disappear that nuclear looses, asparagine, BAIXIAO DAN etc., all different curative effect of obtaining degree.

The object of the present invention is to provide and a kind of cyclomastopathy is had comparatively ideal Chinese medicine preparation---the nodules of the breast oral liquid looses.

The diffusing nodules of the breast oral liquid of Chinese medicine preparation of the present invention adopts seven flavor Chinese medicine processing and preparing to form, and this seven flavor medicine is a trichosanthes fruit; Green Pericarpium Citri Reticulatae; Rhizoma Arisaematis; Herba Scutellariae Barbatae; Fructus Toosendan; Flos Chrysanthemi Indici; Rhizoma Cyperi.

The formula proportion of its medicine of respectively distinguishing the flavor of is: trichosanthes fruit: 5-16; Green Pericarpium Citri Reticulatae: 5-16; Rhizoma Arisaematis: 5-16; Herba Scutellariae Barbatae: 8-19; Fructus Toosendan: 8-19; Flos Chrysanthemi Indici: 8-19; Rhizoma Cyperi: 5-16.

The preparation process of above-mentioned preparation can be undertaken by the routine techniques of Chinese medicine.

Concrete preparation method is: above seven flavors are got it filled by above-mentioned prescription, decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, liquid before merging filtered, decompression filtrate recycling ethanol to relative density is the clear paste of 1.18-1.20 (room temperature), adds simple syrup 42.5ml, potassium sorbate 2g, add water and adjust total amount to 1000ml, stir evenly, filter embedding, sterilization, promptly.

Below by embodiment and clinical practice the present invention is given to illustrate further.Embodiment 1: the nodules of the breast oral liquid preparation of loosing

Claim trichosanthes fruit 3g; Rhizoma Arisaematis 3.5g; Herba Scutellariae Barbatae 2.5g; Fructus Toosendan 5g; Flos Chrysanthemi Indici 4.5g; Rhizoma Cyperi 4g; Green Pericarpium Citri Reticulatae 3.5g, 7 Chinese medicines add the 300ml decocting and boiled 2 hours, take out decoction liquor, adding the 200ml decocting again boiled 1 hour, merge 2 times decoction liquor, be concentrated into 20ml, add 20ml9.5% ethanol again, stir, centrifugalize goes out precipitation, and in widely different stream device, the widely different stream that reduces pressure is handled supernatant, obtain about 20ml concentrated solution, be effective ingredient.The aqueous solution 30ml that adds the preparation of 10g simple syrup and 0.01g potassium sorbate, the 50ml nodules of the breast oral liquid effective ingredient that looses is about 40%, be 2 oral liquid measures (25ml/ props up).Embodiment 2: the clinical practice of the nodules of the breast oral liquid that looses is suffered from the cyclomastopathy patient to 130 examples and is carried out clinical follow-up observation, and 100 examples are organized in treatment, utilizes by the oral liquid of embodiment 1 preparation and makes medicine; Matched group 30 examples, RUPIXIAO tablet, treatment group and matched group patient age distribution situation, disease time contrast, lump size cases, the contrast of acute mastitis situation, administrated method and medication

The time comparing result is listed by table 1--table 5.

Table 1 treatment group and matched group patient age distribution situation

＜30 years old 31～40 years old 41～50 years old 51～60 years old ＞60 years oldGroup

The example routine number of the routine number of the routine number of the routine number of number (%) (%) (%) (%) (%) treatment group 20 (20) 47 (47) 24 (24) 6 (6) 3 (3) matched groups 10 (33.3) 14 (46.4) 4 (13.3) 1 (3.4) 1 (3.4)

Table 2 treatment group and the contrast of matched group disease time

＜January 2～March 4～June 7～December ＞December On average Disease timeGroup

The example routine number of the routine number of the routine number of the routine number of number (%) (%) (%) (%) (%) month treatment group 30 (30) 30 (30) 15 (15) 13 (13) 12 (12) 5.6 matched groups 6 (20) 13 (43.4) 2 (6.6) 3 (10) 6 (20) 5.63

Table 3 treatment group and the contrast of matched group patient lump size

＜3cm 3.1～5cm ＞5cm The lamellar plumpness The single-shot tuberosity Multiple TuberosityGroup

The example routine number of the routine number of the routine number of the routine number of the routine number of number (%) (%) (%) (%) (%) (%) treatment group 59 (59) 26 (26) 3 (3) 12 (12) 30 (30) 70 (70) matched groups 6 (20) 13 (43.4) 2 (6.6) 3 (10) 6 (20) 24 (80)

Table 4 treatment group and the contrast of matched group acute mastitis situation

Companion acute mastitis person The relevant person of acute mastitis with menstrual cycleGroup

The example routine number of number (%) (%) treatment group 98 (98) 63 (64.3) matched groups 30 (100) 22 (73.3)

Table 5 treatment group and the contrast of matched group administration time

20 days 40 days 60 days ＞60 daysGroup

The example routine number of the routine number of the routine number of number (%) (%) (%) (%) treatment group 20 (20) 43 (43) 34 (34) 3 (3) matched groups 3 (10) 20 (66.7) 5 (16.7) 2 (6.6)

Embodiment 3: patient woman, 42 years old, the cadre of Shenzhen.Be diagnosed as cyclomastopathy by Guangzhou Zhongshan Medical Univ. oncology in June, 1991, and companion's fibroadenoma forms.Because of coronary heart disease refusal operative treatment is arranged.Successively at 11 tame hospital therapies of 6 provinces and cities, diagnosis is the same.Took multiple in, western drug and application compress (Chinese medicine and Western medicine), all to no effect, hypertrophy increases the weight of all the more.In October, 1994 in menstruation a few days ago, breast is logical add huge, the about 2.5cm*2.5cm of two swelling of the breast pieces.Obey the nodules of the breast oral liquid that looses since on November 23rd, 1994, mastalgia alleviates after 1 month, mastalgia complete obiteration after 3 months.Clap X-ray molybdenum target sheet and confirm (X-192943), the hypertrophy video disappears, and the biateral fibre adenoma dwindles 1/3.

Embodiment 4: patient woman, and 62 years old, cyclomastopathy 2 years, companion's acupuncture sample mastalgia, the outer swollen thing 2cm of quadrant capsule reality that goes up of left side breast, film making confirms.Once obeyed nearly 40 bottles of RUPIXIAO nearly 1 year, effect does not show.Nineteen ninety-five 5 rose more on the 4th, and clothes loose 40 days two courses of treatment of nodules of the breast oral liquid altogether.Check on July 5, the left side lump disappears, and mastalgia disappears.

Social benefit and economic benefit: this preparation was applied to the clinical consumption that only calculates a hospital at inventor place so far in 1994 according to incompletely statistics, its distribution amount increases to from annual 30000 boxes that (box contains 10 more than 150,000 boxes, per three weeks of the course of treatment are totally 8 boxes): patient's number of taking medicine increased to more than 150,000 person-times from more than 30,000 person-time of every year, and the patient of 16 other provinces and towns has been developed in the patient source by the patient who only is at first this city.The therapeutic effect of diffusing nodules of the breast oral liquid obtains general good praise in vast breast disease people.

Evaluation criterion: cure, lump and mastalgia all disappear; Produce effects, lump are dwindled＞disappearance of 1/2 mastalgia; Effectively, swollen disobey piece and dwindle＜1/2, mastalgia alleviates; Invalid, lump size and mastalgia situation no change.Treatment group and the contrast of matched group curative effect situation are provided by table 6.

Table 6 treatment group and the contrast of matched group curative effect situation

Invalid Effectively Produce effects Cure Total effective rateGroup

The example routine number of the routine number of the routine number of the routine number of number (%) (%) (%) (%) (%) treatment group 8 (8) 26 (26) 41 (41) 25 (25) 92 (92) 1) matched group 23 (76.7) 6 (20) 1 (3.3) 0 (0) 7 (23.3) is annotated: ¹⁾P＜0.001

By embodiment, Chinese medicine preparation Shanru oral liquid of the present invention has comparatively ideal therapeutic effect to cyclomastopathy.

Claims (1)

1. Chinese medicine preparation for the treatment of cyclomastopathy is characterized in that it is made by the following weight proportion raw material: Fructus Trichosanthis 5-16, green Pericarpium Citri Reticulatae 5-16, Rhizoma Arisaematis 5-16, Herba Scutellariae Barbatae 8-19, Fructus Toosendan 8-19, Flos Chrysanthemi Indici 8-19, Rhizoma Cyperi 5-6.