CN112790755A - Electrical impedance detection and online treatment equipment and method for flowing thrombus - Google Patents
Electrical impedance detection and online treatment equipment and method for flowing thrombus Download PDFInfo
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
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- A—HUMAN NECESSITIES
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3669—Electrical impedance measurement of body fluids; transducers specially adapted therefor
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Abstract
The invention discloses an electrical impedance detection and online treatment device and method for flowing thrombus, which comprises a device shell, wherein a touch liquid crystal screen is fixedly installed at the top of the front surface of the device shell, an encapsulation groove is formed in the middle of the front surface of the device shell, an operation panel is encapsulated in the encapsulation groove, a moving mechanism is installed between the operation panel and the device shell, a device cavity is formed in the bottom of the front surface of the device shell, and a control circuit board and an EIST sensor are fixedly installed in the device cavity. The invention can accurately detect the blood state in the extracorporeal circulation system; the size and the quantity of thrombus flowing in the extracorporeal circulation system and the position information of the cross section of the circulation pipeline can be accurately detected. The control of the blood environment in the circulating pipeline is facilitated, the detected information is used for controlling the administration dosage of the anticoagulant, the automatic regulation and control of the administration dosage are facilitated, and the treatment failure caused by excessive administration to the injury or insufficient administration of a patient is relieved.
Description
Technical Field
The invention relates to an electrical impedance detection and online treatment device, in particular to an electrical impedance detection and online treatment device and method for a flowing thrombus, and belongs to the technical field of medical treatment.
Background
The extracorporeal circulation equipment plays a very positive role in treating patients with heart failure, but at present, thrombus is easily generated due to poor biocompatibility of materials for manufacturing the extracorporeal circulation equipment, the occurrence of the thrombus can cause mechanical failure of the extracorporeal circulation equipment, equipment halt is caused, another serious problem is that the thrombus formed in extracorporeal circulation and circulation pipelines can cause serious injury to human bodies and even cause death of the patients once the thrombus flows into the human bodies along with blood circulation, the most common thrombus prevention means at present is to inject a large amount of anticoagulant into the human bodies to prevent the formation of the anticoagulant, the use of the anticoagulant can effectively relieve the thrombus formation, but new problems are brought, when the dosage of the anticoagulant injected is too large, serious bleeding can be caused, the health of the patients can be threatened, therefore, the online feedback control on the dosage of the anticoagulant according to the size and the quantity of the thrombus is required, but at present, no good online detection means for thrombus exists, and the invention provides a real-time thrombus detection, administration control and online diagnosis method based on electrical impedance detection aiming at the situations, which is used for promoting the development of intelligent medical equipment;
electrical Impedance Tomography (EIT) and Electrical Impedance Spectroscopy (EIS) are common electrical detection means, the EIT technique has the advantages that whether thrombus exists in a blood circuit or not can be visually shown, the shape and position information of the thrombus can be visually shown, but the possibility of generation of the thrombus cannot be detected, the administration of a gradient control anticoagulant is not facilitated, the EIS technique can detect the possibility of generation of the thrombus but cannot directly show whether the thrombus exists or not, so that the EIS technique cannot respond to sudden thrombus, the electrical impedance detection technique (EIST) is an organic combination of the EIS and the EIT, and meanwhile, the intuitiveness of the EIT technique and the accuracy of the EIS technique are realized.
Disclosure of Invention
The invention aims to provide an electrical impedance detection and on-line treatment device and method for flowing thrombus, and solve the problems that the EIT technology provided in the background technology has the advantages that whether thrombus exists in a blood circuit or not, the shape and the position information of the thrombus can be visually displayed, but the possibility of generating the thrombus cannot be detected, the administration of a gradient control anticoagulant is not facilitated, the EIS technology can detect the possibility of generating the thrombus but cannot directly display whether the thrombus exists or not, and therefore the EIS technology cannot respond to sudden thrombus.
In order to achieve the purpose, the invention provides the following technical scheme: the device comprises a device shell, wherein a touch liquid crystal screen is fixedly installed at the top of the front of the device shell, an encapsulation groove is formed in the middle of the front of the device shell, an operation panel is encapsulated in the encapsulation groove, a moving mechanism is installed between the operation panel and the device shell, a device cavity is formed in the bottom of the front of the device shell, a sealing door is hinged to one side of the device cavity, a control circuit board and an EIST sensor are fixedly installed in the device cavity, heat dissipation holes are formed in the middle of two sides of the device shell, a plurality of USB interfaces are fixedly installed at the bottom of one side of the device shell at equal intervals, the USB interfaces are connected with a cloud server, an extracorporeal circulation system and a dosing device through data lines, a power line is fixedly installed at the back of the device shell, and universal wheels are fixedly installed at four corners of the bottom end, the USB interface, the touch liquid crystal screen, the operating panel and an EIST (electrical impedance spectroscopy imaging) sensor are all electrically connected with the control circuit board, the surface of the control circuit board is respectively provided with an FPG-ARM processing chip, a network connection module, a man-machine interaction module, a signal acquisition module, a signal generation module, a VCCS (voltage controlled current source) module, a multiplexing module and a drug administration control module, the network connection module, the man-machine interaction module, the signal acquisition module, the signal generation module, the VCCS module, the multiplexing module and the drug administration control module are all electrically connected with the FPG-ARM processing chip, and an embedded operating system and application software are packaged inside the FPG-ARM processing chip.
As a preferred technical scheme of the invention, the moving mechanism comprises servo motors and gears, motor grooves are formed in corners of two sides of the packaging groove, the servo motors of the same type are fixedly mounted in the two motor grooves, the gears are fixedly mounted on output shafts of the two servo motors, sliding grooves are formed in two sides of the operation panel, tooth grooves are formed in bottoms of the two sliding grooves, the two gears are meshed with the corresponding tooth grooves, and the servo motors are electrically connected with the FPG-ARM processing chip.
As a preferred technical solution of the present invention, the network connection module includes a signal receiving unit and a signal sending unit, and is used for controlling a bridge between the circuit board and the cloud server to establish communication, upload a data file, and download a data file.
As a preferred technical scheme of the invention, the man-machine exchange module is used for controlling the operation of an operating system and application software by a touch liquid crystal screen and an operating panel.
As a preferred technical scheme of the invention, the signal acquisition module and the signal generation module adopt an ADC system with high bandwidth, high speed and high precision and a signal conditioning circuit thereof for signal acquisition and signal generation.
As a preferred embodiment of the present invention, the VCCS module includes a conversion circuit for converting a voltage signal generated by the signal generation circuit into an excitation current signal.
As a preferred technical solution of the present invention, the multiplexing module connects the signal acquisition module and the VCCS module with the EIST sensor in a time-division multiplexing manner.
As a preferred technical scheme of the invention, the application software comprises an EIS frequency sweeping and fitting function, an EIT imaging function, an anticoagulant administration control function and an extracorporeal circulation system control function.
As a preferable technical scheme of the invention, the method comprises the following steps:
s1: firstly, detecting the general blood coagulation state from an EIST sensor by using an EIS (electrical impedance spectroscopy) technology, and combining the previously stored data of the hemagglutination degree-thrombosis probability-anticoagulant administration amount to obtain a first part judgment standard of the administration amount;
s2: detecting whether flowing thrombus exists in a circulating pipeline by using an EIT (electrical impedance tomography) technology, wherein four states occur at the moment, namely a, EIS are not condensed, and EIT is not thrombus; b. EIS has coagulation, EIT has no thrombus; c. EIS has no coagulation, EIT has thrombus; d. EIS has coagulation, EIT has thrombus;
s3: aiming at the states of no coagulation of EIS and no thrombus of EIT, the FPG-ARM processing chip controls the administration control module to stop the administration of anticoagulant and enters the next detection cycle;
s4: aiming at the states of coagulation of EIS and no thrombus of EIT, the administration control module controlled by the FPG-ARM processing chip is used for administering according to the data of hemagglutination degree, thrombus formation probability and anticoagulant administration amount, and the EIS is mainly controlled;
s5: aiming at the situation that EIS is not coagulated and EIT has a thrombus state, which indicates that a place with unsmooth blood sedimentation exists in a circulating pipeline and thrombus locally appears, the circulating pipeline is unreasonably arranged, after a doctor is informed, according to diagnosis, an EIST device controls and switches a standby circulating loop, and meanwhile, the dosage is increased, and the EIT is dominant;
s6: aiming at the coagulation of EIS and the thrombus state of EIT, the whole blood environment is in a high coagulation state at the moment and needs emergency treatment, EIST equipment informs a doctor through a cloud server report, controls to increase the administration dosage, temporarily controls the state of an illness, controls to switch a standby circulation pipeline, and continuously monitors until the doctor arrives.
Compared with the prior art, the invention has the beneficial effects that:
1. the invention relates to an electrical impedance detection and on-line treatment device and method for a flowing thrombus, which can accurately detect the blood state in an extracorporeal circulation system; the size and the quantity of thrombus flowing in the extracorporeal circulation system and the position information of the cross section of the circulation pipeline can be accurately detected. Is favorable for controlling the blood environment in the circulating pipeline.
2. According to the electrical impedance detection and on-line treatment equipment and method for the flowing thrombus, the detected information is used for controlling the administration dosage of the anticoagulant, so that the automatic regulation and control of the administration dosage are facilitated, and the treatment failure caused by excessive administration to the injury or insufficient administration of a patient is relieved.
3. According to the equipment and the method for the electrical impedance detection and the online treatment of the flowing thrombus, the detection information is uploaded to the cloud, so that a doctor can conveniently perform online monitoring and diagnosis on the condition of a patient, and the frequency and the workload of the doctor going to the site are reduced.
4. According to the impedance detection and on-line treatment equipment and method for the flowing thrombus, the detected information is used for evaluating the working state of the circulating system, whether the standby circulating pipeline needs to be switched or not can be judged in time, and the reliability of the whole extracorporeal circulating system is favorably guaranteed. Finally, the method can ensure that the physical health condition of a patient using the extracorporeal circulation equipment is not influenced by thrombus generated in the circulation pipeline, and greatly improves the treatment effect and the application range of the equipment.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic view of the connection structure of the operation panel according to the present invention;
FIG. 3 is a block diagram of the device modules of the present invention;
FIG. 4 is a block diagram of a connection module of the present invention;
FIG. 5 is a block diagram of the process of the present invention.
In the figure: 1. an equipment housing; 2. touching the liquid crystal screen; 3. a packaging groove; 4. an operation panel; 5. an equipment chamber; 6. a sealing door; 7. heat dissipation holes; 8. a USB interface; 9. a power line; 10. a universal wheel; 11. a motor slot; 12. a servo motor; 13. a tooth socket; 14. a gear.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-5, the present invention provides an electrical impedance detection and on-line treatment apparatus and method for a flowing thrombus, comprising:
according to the drawings 1-5, the device comprises a device shell 1, a touch liquid crystal screen 2 is fixedly installed at the top of the front of the device shell 1, a packaging groove 3 is formed in the middle of the front of the device shell 1, an operation panel 4 is packaged in the packaging groove 3, a moving mechanism is installed between the operation panel 4 and the device shell 1, a device cavity 5 is formed in the bottom of the front of the device shell 1, a sealing door 6 is hinged to one side of the device cavity 5, a control circuit board and an EIST sensor are fixedly installed in the device cavity 5, heat dissipation holes 7 are formed in the middle of two sides of the device shell 1, a plurality of USB interfaces 8 are fixedly installed at the bottom of one side of the device shell 1 at equal intervals, the USB interfaces 8 are connected with a cloud server, an extracorporeal circulation system and a dosing device signal through data lines, a power line 9 is fixedly installed at the back of the device shell 1, and, the USB interface 8, the touch liquid crystal screen 2, the operating panel 4 and an EIST (electrical impedance spectroscopy imaging) sensor are electrically connected with the control circuit board, the surface of the control circuit board is respectively provided with an FPG-ARM processing chip, a network connection module, a man-machine interaction module, a signal acquisition module, a signal generation module, a VCCS (voltage controlled current source) module, a multiplexing module and a drug administration control module, the network connection module, the man-machine interaction module, the signal acquisition module, the signal generation module, the VCCS module, the multiplexing module and the drug administration control module are electrically connected with the FPG-ARM processing chip, and an embedded operating system and application software are packaged in the FPG-ARM processing chip.
The invention uses EIST technology to carry out thrombus on-line detection and anticoagulant dosage control, wherein EIS is used for continuously detecting the coagulation degree of whole blood cells in a circulating system, and the anticoagulant dosage is adjusted according to the relation between cell coagulation degree data and thrombus formation probability and anticoagulant injection quantity;
a. if the EIS shows that the degree of coagulation of the environmental blood cells is high, the dosage of the anticoagulant is insufficient, the dosage is increased, and meanwhile, the dosage is reported to the cloud, so that a doctor can obtain real-time information and judge whether a standby line needs to be switched.
b. If the EIS shows that the degree of hemagglutination of the environment is low, the local circulation in the circulation pipeline is unsmooth, the circulation pipeline is reported to the cloud, the standby circulation pipeline is switched in time, and meanwhile, a doctor is reminded to check the reasonability of the circulation loop arrangement.
According to the drawings of fig. 1 and 2, the moving mechanism comprises servo motors 12 and gears 14, motor grooves 11 are formed in corners of two sides of the packaging groove 3, the servo motors 12 of the same type are fixedly mounted inside the two motor grooves 11, the gears 14 are fixedly mounted on output shafts of the two servo motors 12, sliding grooves are formed in two sides of the operation panel 4, tooth grooves 13 are formed in groove bottoms of the two sliding grooves, the two gears 14 are meshed with the corresponding tooth grooves 13, and the servo motors 12 are electrically connected with the FPG-ARM processing chip;
through the work of FPG-ARM processing chip control servo motor 12, rotate through servo motor 12 and drive the rotation of gear 14, through the removal of the rotation control operating panel 4 of gear 14, be convenient for remove operating panel 4 to the inside of encapsulation groove 3 when not using, reduce the dust and deposit on operating panel 4 surface, influence operating panel 4's sensitivity
As shown in fig. 1, 3 and 4, the network connection module includes a signal receiving unit and a signal transmitting unit, the system is used for establishing communication between a control circuit board and a cloud server, uploading and downloading data file bridges, a man-machine exchange module is used for touching a liquid crystal screen 2, an operation panel 4 controls an operation system and application software to work, a signal acquisition module and a signal generation module adopt an ADC system with high bandwidth, high speed and high precision and a signal conditioning circuit thereof for signal acquisition and signal generation, a VCCS module converts voltage signals generated by the signal generation circuit into excitation current signals, a multiplexing module adopts a time-sharing multiplexing mode to connect the signal acquisition module and the VCCS module with an EIST sensor, the application software comprises an EIS frequency sweeping and fitting function, an EIT imaging function, an anticoagulant drug administration control function and an extracorporeal circulation system control function.
When the equipment is used, firstly, a power supply is connected through a power line 9, signal connection is respectively established with a cloud server, an extracorporeal circulation system and drug administration equipment through a USB interface 8, then a servo motor 12 is started, a gear 14 is driven to rotate through the rotation of the servo motor 12, an operation panel 4 is driven to move through the rotation of the gear 14, so that the operation panel 4 is moved out of a packaging groove 3, then, an EIS (electrical impedance spectroscopy) technology is used for obtaining the total blood coagulation state from an EIST sensor, the data of the previously stored blood cell coagulation degree, the thrombus formation probability and the anticoagulant drug dosage are combined to obtain a first part judgment standard of the drug dosage, an EIT (electrical impedance tomography) technology is used for detecting whether the flowing thrombus exists in a circulation pipeline, and at the moment, four states occur, a. EIS has no coagulation, EIT has no thrombus; b. EIS has coagulation, EIT has no thrombus; c. EIS has no coagulation, EIT has thrombus; d. EIS has coagulation, EIT has thrombus, aiming at the non-coagulation of EIS and the non-thrombus state of EIT, FPG-ARM processing chip controls a drug administration control module to stop anticoagulant administration, the next detection cycle is entered, aiming at the coagulation of EIS and the non-thrombus state of EIT, FPG-ARM processing chip controls the drug administration control module to administer drug according to the data of hemagglutination degree, thrombus formation probability and anticoagulant amount, EIS administration control is led, aiming at the non-coagulation of EIS and the thrombus state of EIT, which indicates that the circulating pipeline has unsmooth blood deposition and locally generates thrombus, the circulating pipeline is unreasonably arranged, after the medical treatment, according to the diagnosis, EIST equipment controls and switches a standby circulating loop, the drug administration amount is increased, EIT is led, aiming at the coagulation of EIS and the thrombus state of EIT, which indicates that the whole blood environment is in a high coagulation state, and emergency treatment is needed, the EIST equipment informs a doctor through a cloud server report, controls to increase the administration dosage, temporarily controls the state of an illness, controls to switch a standby circulating pipeline, and continuously monitors until the doctor arrives.
In the description of the present invention, it is to be understood that the ease of description and simplicity of description are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and is not to be considered limiting.
In the present invention, unless otherwise explicitly specified or limited, for example, it may be fixedly attached, detachably attached, or integrated; can be mechanically or electrically connected; the terms may be directly connected or indirectly connected through an intermediate, and may be communication between two elements or interaction relationship between two elements, unless otherwise specifically limited, and the specific meaning of the terms in the present invention will be understood by those skilled in the art according to specific situations.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (9)
1. The utility model provides an electrical impedance detection and online treatment equipment for flowing thrombus, includes equipment casing (1), its characterized in that, the positive top fixed mounting of equipment casing (1) has touch LCD screen (2), equipment casing (1) positive middle part has seted up encapsulation groove (3), the inside encapsulation of encapsulation groove (3) has operating panel (4), install moving mechanism between operating panel (4) and equipment casing (1), equipment chamber (5) have been seted up to the positive bottom of equipment casing (1), one side transposition of equipment chamber (5) has connect sealing door (6), the inside fixed mounting of equipment chamber (5) has control circuit board and EIST sensor, louvre (7) have all been seted up at the middle part of equipment casing (1) both sides, the bottom equidistance fixed mounting of equipment casing (1) one side has a plurality of USB interfaces (8), the USB interface (8) is in signal connection with a cloud server, an extracorporeal circulation system and a dosing device through a data line, a power line (9) is fixedly installed on the back of the device shell (1), universal wheels (10) are fixedly installed at four corners of the bottom end of the device shell (1), the USB interface (8), a touch liquid crystal screen (2), an operation panel (4) and an EIST (electrical impedance spectroscopy imaging) sensor are electrically connected with a control circuit board, an FPG-ARM processing chip, a network connection module, a man-machine interaction module, a signal acquisition module, a signal generation module, a VCCS (voltage control current source) module, a multiplexing module and a dosing control module are installed on the surface of the control circuit board respectively, the network connection module, the man-machine interaction module, the signal acquisition module, the signal generation module, the VCCS module, the multiplexing module and the dosing control module are electrically connected with the FPG-ARM processing chip, and an embedded operating system and application software are packaged in the FPG-ARM processing chip.
2. An electrical impedance detection and on-line treatment apparatus for flowing thrombus according to claim 1 wherein: moving mechanism includes servo motor (12) and gear (14), motor groove (11), two have all been seted up to the edge of encapsulation groove (3) both sides equal fixed mounting in inside of motor groove (11) has servo motor (12) of the same kind model, two the equal fixed mounting of output shaft of servo motor (12) has gear (14), the spout has all been seted up to the both sides of operating panel (4), two tooth's socket (13), two have all been seted up to the tank bottom of spout gear (14) are connected with tooth's socket (13) meshing that corresponds, just servo motor (12) and FPG-ARM handle chip electric connection.
3. An electrical impedance detection and on-line treatment apparatus for flowing thrombus according to claim 1 wherein: the network connection module comprises a signal receiving unit and a signal sending unit and is used for controlling a circuit board to establish a bridge for communicating with a cloud server, uploading data files and downloading the data files.
4. An electrical impedance detection and on-line treatment apparatus for flowing thrombus according to claim 1 wherein: the man-machine exchange module is used for touching the liquid crystal screen (2) and the operation panel (4) to control the operation system and the application software to work.
5. An electrical impedance detection and on-line treatment apparatus for flowing thrombus according to claim 1 wherein: the signal acquisition module and the signal generation module adopt an ADC system with high bandwidth, high speed and high precision and a signal conditioning circuit thereof for signal acquisition and signal generation.
6. An electrical impedance detection and on-line treatment apparatus for flowing thrombus according to claim 1 wherein: the VCCS module converts a voltage signal generated by the signal generating circuit into an excitation current signal.
7. An electrical impedance detection and on-line treatment apparatus for flowing thrombus according to claim 1 wherein: the multiplexing module adopts a time-sharing multiplexing mode to connect the signal acquisition module and the VCCS module with the EIST sensor.
8. An electrical impedance detection and on-line treatment apparatus for flowing thrombus according to claim 1 wherein: the application software comprises an EIS frequency sweep and fitting function, an EIT imaging function, an anticoagulant administration control function and an extracorporeal circulation system control function.
9. An electrical impedance detection and on-line treatment method for flowing thrombus is characterized in that: the method comprises the following steps:
s1: firstly, detecting a general blood coagulation state from an EIST sensor by using EIS (electrical impedance spectroscopy), and combining the previously stored data of the hemagglutination degree-thrombosis probability-anticoagulant administration amount to obtain a first part judgment standard of the administration amount;
s2: using EIT (electrical impedance tomography) to detect whether flowing thrombus exists in a circulating pipeline, wherein four states occur, namely a, EIS is not condensed, and EIT is not thrombus; b. EIS has coagulation, EIT has no thrombus; c. EIS has no coagulation, EIT has thrombus; d. EIS has coagulation, EIT has thrombus;
s3: aiming at the states of no coagulation of EIS and no thrombus of EIT, the FPG-ARM processing chip controls the administration control module to stop the administration of anticoagulant and enters the next detection cycle;
s4: aiming at the states of coagulation of EIS and no thrombus of EIT, the administration control module controlled by the FPG-ARM processing chip is used for administering according to the data of hemagglutination degree, thrombus formation probability and anticoagulant administration amount, and the EIS is mainly controlled;
s5: aiming at the situation that EIS is not coagulated and EIT has a thrombus state, which indicates that a place with unsmooth blood sedimentation exists in a circulating pipeline and thrombus locally appears, the circulating pipeline is unreasonably arranged, after a doctor is informed, according to diagnosis, an EIST device controls and switches a standby circulating loop, and meanwhile, the dosage is increased, and the EIT is dominant;
s6: aiming at the coagulation of EIS and the thrombus state of EIT, the whole blood environment is in a high coagulation state at the moment and needs emergency treatment, EIST equipment informs a doctor through a cloud server report, controls to increase the administration dosage, temporarily controls the state of an illness, controls to switch a standby circulation pipeline, and continuously monitors until the doctor arrives.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113413148A (en) * | 2021-08-24 | 2021-09-21 | 常州先趋医疗科技有限公司 | Signal processing method and device for improving effect of impedance biosensor |
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