CN112774571A - Dispersing and condensing production process of high-uniformity large-particle-size pellets - Google Patents
Dispersing and condensing production process of high-uniformity large-particle-size pellets Download PDFInfo
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- CN112774571A CN112774571A CN202011570399.9A CN202011570399A CN112774571A CN 112774571 A CN112774571 A CN 112774571A CN 202011570399 A CN202011570399 A CN 202011570399A CN 112774571 A CN112774571 A CN 112774571A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D8/00—Cold traps; Cold baffles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/836—Mixing plants; Combinations of mixers combining mixing with other treatments
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
- F25D3/10—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air
- F25D3/102—Stationary cabinets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
- A61J2200/40—Heating or cooling means; Combinations thereof
- A61J2200/44—Cooling means
Abstract
The invention discloses a dispersing and condensing production process of high-uniformity large-particle-size pellets, which comprises the following steps of: weighing materials, and mixing, homogenizing and stirring the materials; forming a low-temperature cold trap environment in the cold trap tower; the materials after mixing, homogenizing and stirring are conveyed to a material nozzle through a material conveying pipe, the material is sprayed out through the material nozzle by the power provided by the rotation of a feeding pump, and compressed air is sprayed out through a compressed air nozzle wrapped in the material nozzle to promote the rapid dispersion of the materials; the dispersed materials fall into a cold trap tower, free falling motion is carried out in the cold trap tower to form round pills with large particle size, the round pills are rapidly cooled and condensed into micro pills in the low-temperature environment in the cold trap tower, the micro pills fall into a micro pill collecting bottom cover at the bottom of the cold trap tower, and continuous production is carried out until the materials are used up; the invention ensures the content uniformity of the pellets, narrows the particle size distribution of the pellets, increases the yield and lowers the cost.
Description
Technical Field
The invention relates to the field of pharmaceutical preparations, in particular to a dispersion and condensation production process of high-uniformity large-particle-size pellets.
Background
In the present invention, the term pellet refers to a spherical solid having a diameter of not more than 3 mm. The pellet preparation process includes extrusion and spheronization, hot melt extrusion, spherical agglomeration, condensation, freeze drying, powder lamination, fluidized spray granulation, etc.
In the prior art, the production mode of the large-particle-size pellets mostly adopts a dripping pill method in a condensation granulation method for production, the production process of the production mode is complex, cooling oil is mostly adopted as condensate, the pellet weight difference of the prepared pellets is large, the cooling oil is also required to be cleaned by organic solvent, organic solvent residue is easy to cause, and a production workshop is also required to be built into a special explosion-proof workshop; the pellets produced by the fluidized spray granulation process have small particle size, cannot meet the production requirement of pellets with large particle size, and have poor uniformity, wide particle size distribution, poor pellet roundness and adhesion; therefore, a new production process of high-uniformity large-particle-size pellets is urgently needed.
Disclosure of Invention
Aiming at the defects in the technology, the invention provides a dispersing and condensing production process of high-uniformity large-particle-size pellets, materials are rapidly dispersed by compressed air and do free falling motion in a cold trap tower to form large-particle-size round pellets, the round pellets are rapidly cooled and condensed in a low-temperature environment in the cold trap tower to form the pellets, active ingredients in the pellets are effectively protected, the content uniformity of the pellets is ensured, and the particle size distribution of the pellets is narrowed; the production method of the process increases the yield, and the production workshop is safer and has lower cost.
In order to achieve the purpose, the invention provides a dispersing and condensing production process of high-uniformity large-particle-size pellets, which comprises the following steps:
weighing materials, and mixing, homogenizing and stirring the materials;
the materials after mixing, homogenizing and stirring are conveyed to a material nozzle through a material conveying pipe, the material is sprayed out through the material nozzle by the power provided by the rotation of a feeding pump, and compressed air is sprayed out through a compressed air nozzle wrapped in the material nozzle to promote the rapid dispersion of the materials;
the dispersed materials fall into a cold trap tower, free falling motion is carried out in the cold trap tower to form round pills with large particle size, the round pills are rapidly cooled and condensed in the low-temperature environment in the cold trap tower, and the cooled and formed pellets finally fall into a pellet collecting bottom cover at the bottom of the cold trap tower;
the production is continued until the material is used up.
Before the step of falling the dispersed materials into the cold trap tower, opening liquid nitrogen nozzles in the inner cavity of the cold trap tower, spraying liquid nitrogen into the cold trap tower, quickly forming the low-temperature cold trap environment of the cooling tower, wherein the liquid nitrogen nozzles are provided with a plurality of liquid nitrogen nozzles which are respectively arranged at the top and the bottom of the cold trap tower, and uniformly spraying the liquid nitrogen into the cold trap tower, so that the temperature of the inner cavity of the cold trap tower is controlled to be-20 ℃ to-180 ℃.
In the step of opening a liquid nitrogen nozzle of the inner cavity of the cold trap tower to spray liquid nitrogen into the cold trap tower so that the inner cavity of the cold trap tower forms a low-temperature cold trap environment quickly, the outer wall of the cold trap tower is provided with a heat insulation layer, and the heat insulation layer completely covers the inner cavity of the cold trap tower and is used for slowing down external heat from entering the inner cavity of the cold trap tower.
Wherein, in the step of conveying the material subjected to mixing, homogenizing and stirring treatment to a material nozzle through a material conveying pipe, a heat-insulating spacer bush is sleeved on the outer wall of the material conveying pipe to keep the material in a constant temperature state, the heat-insulating spacer bush is one of a constant-temperature water bath spacer bush or a constant-temperature oil bath spacer bush, and the heat-insulating temperature of the material is controlled to be 40-70 ℃;
wherein, in the step of ejecting the material through the material nozzle by the power provided by the rotation of the feeding pump, the rotation speed of the feeding pump is 50-600 rpm.
Wherein, in the step of spraying the material through the material nozzle by the power provided by the rotation of the feeding pump, the inner diameter of the material nozzle is 0.1 mm-2 mm.
Wherein, in the step of spraying compressed air from a compressed air nozzle wrapped in the material nozzle, the pressure of the compressed air is 0.1 mpa-0.2 mpa.
Wherein, in the step of forming round pills with larger grain diameter by free falling body movement in the material cold trap tower, the grain diameter of the round pills is 0.1 mm-3 mm.
Wherein the diameter of the cold trap tower is between 0.5m and 5m, and the height of the cold trap tower is between 1m and 20 m.
After the pellet collecting bottom cover collects the pellets, the elevator controls the pellet collecting bottom cover to be far away from the cold trap tower, and the pellet collecting bottom cover is pushed outwards and the pellets are collected.
The invention has the beneficial effects that: compared with the prior art, the dispersing and condensing production process of the high-uniformity large-particle-size pellets provided by the invention comprises the following steps of: weighing materials, and mixing, homogenizing and stirring the materials; opening a liquid nitrogen nozzle of the inner cavity of the cold trap tower to spray liquid nitrogen into the cold trap tower, so that the inner cavity of the cold trap tower forms a low-temperature cold trap environment quickly; the materials after mixing, homogenizing and stirring are conveyed to a material nozzle through a material conveying pipe, the material is sprayed out through the material nozzle by the power provided by the rotation of a feeding pump, and compressed air is sprayed out through a compressed air nozzle wrapped in the material nozzle to promote the rapid dispersion of the materials; the dispersed materials fall into a cold trap tower, free falling motion is carried out in the cold trap tower to form round pills with larger particle sizes, the round pills are rapidly cooled and condensed in the low-temperature environment in the cold trap tower, the cooled and formed pellets finally fall into a pellet collecting bottom cover at the bottom of the cold trap tower, and continuous production is carried out until the materials are used up; the material dispersed by compressed air does free falling motion in the cold trap tower to form round pills with larger particle size, and the round pills are rapidly cooled and condensed in the low-temperature environment in the cold trap tower to form micro pills, so that the active ingredients in the micro pills are effectively protected, the content uniformity of the micro pills is ensured, and the particle size distribution of the micro pills is narrowed; the production method of the process increases the yield, and the production workshop is safer and has lower cost.
Drawings
FIG. 1 is a diagram of the process steps of the present invention;
FIG. 2 is a perspective view of the process production apparatus of the present invention;
FIG. 3 is a cross-sectional view of the process production apparatus of the present invention;
FIG. 4 is a top view of a showerhead assembly of the process production apparatus of the present invention.
The main element symbols are as follows: 1. a liquid nitrogen delivery pipe; 2. a showerhead assembly; 3. a cold trap tower 4, a lifter; 5. a bottom cover; 6. a compressed air delivery pipe; 7. a liquid nitrogen spray head; 8. a heat-insulating layer; 9. a blanking hole; 10. a material conveying pipe; 11. a heat-insulating spacer bush; 12. a material nozzle; 15. a compressed air nozzle; 18. and fixing the base.
Detailed Description
In order to more clearly describe the present invention, the present invention will be further described with reference to the accompanying drawings.
Referring to fig. 1, fig. 2 and fig. 3, the present application specifically provides a dispersion and condensation production process of high-uniformity large-particle-size pellets, which specifically includes the following steps:
weighing materials, and mixing, homogenizing and stirring the materials;
the materials after mixing, homogenizing and stirring are conveyed to a material nozzle through a material conveying pipe, the material is sprayed out through the material nozzle by the power provided by the rotation of a feeding pump, and compressed air is sprayed out through a compressed air nozzle wrapped in the material nozzle to promote the rapid dispersion of the materials;
the dispersed materials fall into a cold trap tower, free falling motion is carried out in the cold trap tower to form round pills with large particle size, the round pills are rapidly cooled and condensed in the low-temperature environment in the cold trap tower, and the cooled and formed pellets finally fall into a pellet collecting bottom cover at the bottom of the cold trap tower;
the production is continued until the material is used up. The pellet production process on the market at present mostly adopts a dropping pill method for production, the production method has complex production process, cooling oil is mostly adopted as condensate, the pellet weight difference of the prepared pellets is large, the cooling oil is also required to be cleaned by organic solvent, organic solvent residue is easy to cause, a special explosion-proof workshop is required to be built in a production workshop, the requirement on the production environment is higher, and the cost required by production is higher; the production process provided by the invention replaces the production method in the prior art, the material sprayed from the material nozzle is quickly dispersed by compressed air, and meanwhile, the material is subjected to surface tension to form round pills in the free falling process, so that the phenomenon that the material is aggregated in the forming process to cause low roundness of the pellets, wide particle size distribution or even adhesion is avoided, meanwhile, the cold trap tower quickly forms a low-temperature environment through liquid nitrogen sprayed from a liquid nitrogen spray head, the low-temperature environment can ensure that the round pills are quickly cooled and solidified when entering the cold trap tower and finally fall into a pellet collection bottom cover for collection, and the production process does not need to use cooling oil, and moreover, the cooling oil is not required to be removed by using an organic solvent, the residue of the organic solvent is completely avoided, the safety of the medicine is improved, meanwhile, a production workshop can be changed from a special explosion-proof workshop into a common workshop, the production efficiency of the production process is extremely high, and the productivity can be effectively improved.
In the present embodiment, mention is made of: referring to fig. 2, in the step of opening a liquid nitrogen nozzle of the inner cavity of the cold trap tower to spray liquid nitrogen into the cold trap tower, so that the inner cavity of the cold trap tower forms a low-temperature cold trap environment quickly, a plurality of liquid nitrogen nozzles are arranged at the top and bottom of the cold trap tower respectively, and liquid nitrogen is uniformly sprayed into the cold trap tower, so that the temperature of the inner cavity of the cold trap tower is controlled between-20 ℃ and-180 ℃; the liquid nitrogen spouts are provided with a plurality of and divide the top and the bottom position of locating the cold-trap tower, and its aim at enables the cold-trap tower inner chamber and forms target low temperature environment fast, and avoids appearing great difference in temperature in same space. The temperature of the inner cavity of the cold trap tower is controlled within the range of-20 ℃ to-180 ℃, the temperature of-20 ℃ to-180 ℃ is the temperature range of condensation forming of the pellets, the pellets can be condensed and formed within the temperature range, but the temperature difference can cause certain influence on the forming of the pellets; in a known embodiment, when the cold trap temperature is-20 to-45 ℃, the pellet forming result is slightly poor, the adhesion phenomenon exists, when the cold trap temperature is-60 to 180 ℃, the pellet forming result is good, and when the cold trap temperature is-170 ℃, the optimal forming effect can be achieved.
In the present embodiment, mention is made of: referring to fig. 3, in the step of opening the liquid nitrogen nozzle of the inner cavity of the cold trap tower to spray liquid nitrogen into the cold trap tower, so that the inner cavity of the cold trap tower forms a low-temperature cold trap environment quickly, the outer wall of the cold trap tower is provided with the insulating layer, the insulating layer completely covers the inner cavity of the cold trap tower and is used for slowing down external heat from entering the inner cavity of the cold trap tower, thereby preventing the external heat from being conducted to the inner cavity of the cold trap tower to influence the low-temperature environment in the cold trap tower, slowing down temperature rise in the cold trap tower, effectively avoiding influence on pellet forming effect due to temperature change, and simultaneously achieving an energy-saving effect.
In the present embodiment, mention is made of: referring to fig. 4, in the step of conveying the material subjected to the mixing, homogenizing and stirring treatment to the material nozzle through the material conveying pipe, the outer wall of the material conveying pipe is sleeved with a heat-insulating spacer sleeve to keep the material in a constant temperature state, and the heat-insulating spacer sleeve is one of a constant-temperature water bath spacer sleeve or a constant-temperature oil bath spacer sleeve to control the heat-insulating temperature of the material to be 40-70 ℃; in an implemented example, effective dissolution of all materials can not be realized below 40 ℃, a constant-temperature spacer sleeve is sleeved on a material conveying pipe, the temperature of the spacer sleeve is transferred to the material conveying pipe to keep the materials at a constant temperature of 40-70 ℃, so that some materials sensitive to the temperature can be in an appropriate temperature range, active ingredients of the materials can be prevented from being influenced by the temperature to the maximum extent, and the materials can fall into a cold trap tower at the same temperature, which is favorable for pellet forming. In one practical example, the material is brought to a constant temperature of 55 ℃.
In the present embodiment, mention is made of: referring to fig. 4, in the step of ejecting the material through the material nozzle by the rotation of the feeding pump, the rotation speed of the feeding pump is 50 to 600rpm, the inner diameter of the material nozzle is 0.1 to 2mm, and in the step of ejecting the compressed air through the compressed air nozzle wrapped in the material nozzle, the compressed air pressure is 0.1 to 0.2mpa, so that the particle size of the pellet during molding is 0.1 to 3mm, and the pellet can be effectively and quickly separated from the material nozzle during ejection, thereby preventing the adhesion phenomenon between the pellet and the pellet, which results in poor uniformity of the pellet, wide distribution of the particle size, poor rounding of the formed pellet, and the adhesion phenomenon.
In the present embodiment, mention is made of: referring to fig. 2, the diameter of the cold trap tower is 0.5m to 5m, the height is 1m to 20m, the diameter of the cold trap tower affects the range of material spraying and dispersing, the height of the cold trap tower affects the time of the pellets in free-fall movement, and further affects the pellet forming effect, the pellet forming effect can be optimized by the proper height and diameter, and the diameter adopted by the cold trap tower which is used is 2m and 5 m. And each pellet falling into the pellet collecting bottom cover is ensured to be condensed and formed.
Mention is made in one embodiment of: referring to fig. 2, after the step of continuous production until the material is used up, the method further includes a step of controlling the pellet collection bottom cover to move away from the cold trap tower by the lifter after the pellet collection bottom cover collects the pellets, and pulling out the pellet collection bottom cover and collecting the pellets; the pellet collecting bottom cover comprises a lifter and a bottom cover, the bottom cover is arranged in the middle of the lifter, the position of the bottom cover is adjusted by the lifter, and the bottom cover can be pushed out of the bottom of the cold trap tower; the lifter is used for controlling the automatic lifting of the pellet collecting bottom cover, the lifter controls the pellet collecting bottom cover to move towards the bottom close to the cold trap tower during processing, and finally the pellet collecting bottom cover is abutted against the bottom of the cold trap tower and used for receiving the processed and condensed pellets; the pellet collecting bottom cover adopts a lifting mode to facilitate the taking and collection of the pellets by operators. In one embodiment are mentioned: adjusting parameters of the compressed air pressure and the cold trap temperature of the cold trap tower, and investigating the influence of the compressed air pressure and the cold trap temperature on the pellet forming effect, wherein the following is an experimental data summary table:
from the above table, the pellet molding effect is affected by both the compressed air pressure and the cold trap temperature, wherein the optimal molding effect can be achieved when the compressed air pressure is 0.2mpa and the cold trap temperature is-170 ℃.
In one particular embodiment are mentioned: the equipment circuit adopts PLC and touch screen control, can control the rotational speed of material pump, the rotational speed of material shower nozzle, the temperature of thermostatic water bath or oil bath, adjusts cold trap tower liquid nitrogen jet volume.
The working principle of the application is described in detail as follows:
the preparation method comprises the steps of preparing vitamin AD pellets by using the production process and the production equipment mentioned in the application and referring to fig. 1 to 4, homogenizing and emulsifying the prepared vitamin AD material to obtain high-uniformity emulsion, conveying the material to a material nozzle through a material conveying pipe, wherein in the process, a water bath spacer sleeve is sleeved outside the material conveying pipe to perform water bath heat preservation, and the water bath in a constant temperature spacer sleeve ensures that the temperature of the material is kept at the constant temperature of 55 ℃; simultaneously starting a liquid nitrogen spray head to spray liquid nitrogen into the cold trap tower, reducing the temperature of the inner cavity of the cold trap tower to-120 ℃, and simultaneously controlling a lifter to lift the bottom cover to the bottom of the cold trap tower to abut against and cover the cold trap tower tightly; at the moment, the feeding pump rotates at the rotating speed of 100rpm, the materials are sprayed out through the material spray opening, compressed air is sprayed out through the compressed air spray opening wrapped in the material spray opening, the materials are enabled to be rapidly dispersed, the dispersed materials fall into the cold trap tower and do free falling body motion in the cold trap tower to form round pills with large particle size, the round pills are rapidly cooled and condensed in the low-temperature environment in the cold trap tower, and the vitamin AD micro pills formed by cooling finally fall into the micro pill collecting bottom cover at the bottom of the cold trap tower; after a period of processing, the bottom cover collects a sufficient amount of micro-pills, the equipment stops processing, and the lifter is controlled to enable the bottom cover to do descending movement far away from the bottom of the cold trap tower, so that the bottom cover is separated from the cold trap tower and separated from the cold trap tower to collect the micro-pills, and therefore a complete processing of the whole vitamin AD micro-pills is completed.
In one particular embodiment: referring to fig. 4, the equipment circuit is controlled by PLC and touch screen, and can control the rotation speed of the feeding pump, the start and stop of the compressed air, the temperature of the thermostatic water bath or oil bath, and adjust the liquid nitrogen injection amount of the cold trap tower.
The invention has the advantages that:
1. the material is dispersed by compressed air and then freely falls to form round pills with larger particle size, and the round pills are quickly condensed to form the pellets with uniform particle size by the low-temperature environment of the cold trap tower when passing through the cold trap tower, so that the high roundness and the good uniformity of the produced pellets are ensured.
2. The whole process of conveying the materials adopts a constant-temperature water bath or an oil bath to ensure that the materials are in a constant-temperature state, so as to avoid the influence of the change of the temperature on active ingredients of the materials, especially on the materials which are sensitive to the temperature.
3. The production equipment is simple and easy to operate, the production process does not need to use cooling oil, and does not need to use an organic solvent to remove the cooling oil, so that the residue of the organic solvent is completely avoided, the safety of the medicine is improved, meanwhile, a production workshop can be changed from a special explosion-proof workshop into a common workshop, the production efficiency of the production process is extremely high, and the productivity can be effectively improved.
The above disclosure is only for a few specific embodiments of the present invention, but the present invention is not limited thereto, and any variations that can be made by those skilled in the art are intended to fall within the scope of the present invention.
Claims (10)
1. A dispersing and condensing production process of high-uniformity large-particle-size pellets is characterized by comprising the following steps:
weighing materials, and mixing, homogenizing and stirring the materials;
the materials after mixing, homogenizing and stirring are conveyed to a material nozzle through a material conveying pipe, the material is sprayed out through the material nozzle by the power provided by the rotation of a feeding pump, and compressed air is sprayed out through a compressed air nozzle wrapped in the material nozzle to promote the rapid dispersion of the materials;
the dispersed materials fall into a cold trap tower, free falling motion is carried out in the cold trap tower to form round pills with large particle size, the round pills are rapidly cooled and condensed in the low-temperature environment in the cold trap tower, and the cooled and formed pellets finally fall into a pellet collecting bottom cover at the bottom of the cold trap tower;
the production is continued until the material is used up.
2. The dispersing and condensing production process of high-uniformity large-particle-size pellets according to claim 1, wherein before the step of dropping dispersed materials into the cold trap tower, liquid nitrogen nozzles in the inner cavity of the cold trap tower are opened, liquid nitrogen is sprayed into the cold trap tower, the low-temperature cold trap environment is rapidly formed, the liquid nitrogen nozzles are provided in plurality and are respectively arranged at the top and bottom of the cold trap tower, and liquid nitrogen is uniformly sprayed into the cold trap tower, so that the temperature of the inner cavity of the cold trap tower is controlled to be-20 ℃ to-180 ℃.
3. The dispersing and condensing production process of high-uniformity large-particle-size pellets according to claim 1, wherein in the step of opening a liquid nitrogen nozzle of the inner cavity of the cold trap tower to spray liquid nitrogen into the cold trap tower so that the inner cavity of the cold trap tower forms a low-temperature cold trap environment quickly, the outer wall of the cold trap tower is provided with an insulating layer, and the insulating layer completely covers the inner cavity of the cold trap tower and is used for slowing external heat from entering the inner cavity of the cold trap tower.
4. The process according to claim 1, wherein in the step of delivering the material subjected to the mixing, homogenizing and stirring treatment to the material nozzle through the material delivery pipe, the temperature of the material is kept at a constant temperature by controlling the temperature inside a heat-insulating spacer sleeved on the outer wall of the material delivery pipe, and the temperature of the material is controlled to be 40 ℃ to 70 ℃ by using one of a constant-temperature water bath spacer and a constant-temperature oil bath spacer.
5. The dispersing and condensing production process of high-uniformity large-particle-size pellets according to claim 1, wherein in the step of ejecting the material through the material nozzle by the power provided by the rotation of the feeding pump, the rotation speed of the feeding pump is 50-600 rpm.
6. The dispersing and condensing production process of high-uniformity large-particle-size pellets according to claim 1, wherein in the step of ejecting the material through the material nozzle by the power provided by the rotation of the feeding pump, the inner diameter of the material nozzle is 0.1 mm-2 mm.
7. The dispersing and condensing production process of high-uniformity large-particle-size pellets according to claim 1, wherein in the step of ejecting compressed air from the compressed air ejection port wrapped in the material ejection port, the compressed air pressure is 0.1mpa to 0.2 mpa.
8. The dispersing and condensing production process of high-uniformity large-particle-size pellets according to claim 1, wherein in the step of forming large-particle-size pellets by free-falling body movement in the material cold trap tower, the particle size of the round pellets is 0.1 mm-3 mm.
9. The dispersing and condensing production process of high-uniformity large-particle-size pellets according to claim 1, wherein the diameter of the cold trap tower is 0.5-5 m, and the height is 1-20 m.
10. The process of claim 1, wherein the step of continuously producing pellets until the material is used up further comprises a step of controlling the pellet collection bottom cover to move away from the cold trap tower by the lifter after the pellet collection bottom cover collects the pellets, and pushing the pellet collection bottom cover outwards to collect the pellets.
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| US5922253A (en) * | 1995-05-18 | 1999-07-13 | Alkermes Controlled Therapeutics, Inc. | Production scale method of forming microparticles |
| CN1262636A (en) * | 1997-07-14 | 2000-08-09 | 艾罗奎普有限公司 | Apparatus and method for making uniformly sized and shaped spheres |
| CN104274320A (en) * | 2013-07-11 | 2015-01-14 | 天士力制药集团股份有限公司 | Dropping pill air cooling circulation device and dropping pill production line with air cooling circulation device |
| CN204193877U (en) * | 2014-09-29 | 2015-03-11 | 国药嘉远国际贸易公司 | Prepare the spray-fluidized granulation tower of hollow iodine particle and the tincture of iodine |
| CN105597622A (en) * | 2016-03-09 | 2016-05-25 | 苏州大学 | Freezing temperature-controllable spray freezing tower for preparing micron-sized ice ball particles |
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| CN106563389A (en) * | 2016-11-17 | 2017-04-19 | 天津科技大学 | Spray-freezing microchannel dryer |
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