CN112773438A - Wound closure repairing assembly and preparation process of retractor adapting membrane - Google Patents

Wound closure repairing assembly and preparation process of retractor adapting membrane Download PDF

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Publication number
CN112773438A
CN112773438A CN202110150302.7A CN202110150302A CN112773438A CN 112773438 A CN112773438 A CN 112773438A CN 202110150302 A CN202110150302 A CN 202110150302A CN 112773438 A CN112773438 A CN 112773438A
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fixing
skin
wound
distractor
wound closure
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石锐
刘波
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BEIJING RESEARCH INSTITUTE OF TRAUMATOLOGY AND ORTHOPAEDICS
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BEIJING RESEARCH INSTITUTE OF TRAUMATOLOGY AND ORTHOPAEDICS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
    • A61B17/085—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound with adhesive layer
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/58—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products
    • D01F6/70—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2375/00—Characterised by the use of polyureas or polyurethanes; Derivatives of such polymers
    • C08J2375/04—Polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2489/00—Characterised by the use of proteins; Derivatives thereof

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
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  • Surgery (AREA)
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  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Heart & Thoracic Surgery (AREA)
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Abstract

The invention provides a preparation process of a wound closure repair assembly and a retractor adaptive membrane, which relates to the technical field of medical appliances and comprises the following steps: a first fixing body and a distractor adapter member; the first fixing body is used for being fixed on the skin of a human body, and a fixing groove is formed between the first fixing body and the skin of the human body in an enclosing mode; the retractor adapting component is provided with a wound contact layer, and the retractor adapting component can extend into the fixing groove so that the wound contact layer is attached to the skin wound of the human body. Through fixing first fixed main part on human skin, lead and stretch out ware adaptation component and stretch into the fixed slot that forms between first fixed main part and the human skin, make the wound contact layer on the ware adaptation component that leads remove to the wound position, cover at human wound position, it is difficult to direct nursing on skin to have alleviated the wound nursing membrane that exists among the prior art, can only cover wound nursing membrane on leading the ware, has the technical problem of infecting hidden danger.

Description

Wound closure repairing assembly and preparation process of retractor adapting membrane
Technical Field
The invention relates to the technical field of medical appliances, in particular to a preparation process of a wound closure repair assembly and a retractor adaptive membrane.
Background
External factors such as external forces, heat, current, chemical agents, internal factors such as local blood supply disorders, may cause local skin tissue deficiencies. In clinic, for the treatment of large wounds, the traditional treatment method is to cover the wound surface by a skin flap and skin grafting for repair, but the method has the defects of new damage to a supply area, difference in color and thickness of the skin of the supply area and a receptor, high failure rate of the operation and the like.
The skin stretching technology is a new method for repairing skin tissues, mainly utilizes the extensibility of skin, pulls the skin around a wound to the center by means of an outer stretching device, gradually reduces the wound surface, and finally sews and eliminates the wound. Skin stretching is mainly performed by means of a stretching device, and the skin stretching device is usually used by penetrating the skin on two sides of a wound through fixing needles and pulling the fixing positions towards each other by adopting a pulling material.
However, after the existing retractor is installed, the wound care film is difficult to directly care the skin, and only the wound care film can be covered on the retractor, so that the wound care difficulty is increased, and the probability of wound infection is improved.
Disclosure of Invention
The invention aims to provide a wound closing repair assembly and a preparation process of a distractor adaptive membrane, so as to solve the technical problems that in the prior art, a wound care membrane is difficult to directly care on skin, only the wound care membrane can be covered on the distractor, and the infection hidden danger exists.
In a first aspect, the present invention provides a wound closure repair assembly comprising: a first fixing body and a distractor adapter member;
the first fixing body is used for being fixed on the skin of a human body, and a fixing groove is formed between the first fixing body and the skin of the human body in an enclosing mode;
the distractor adapting member is provided with a distractor adapting film, and the distractor adapting member can extend into the fixing groove so as to enable the distractor adapting film to be attached to the skin wound of the human body.
In an alternative embodiment of the method of the present invention,
the wound closure repair assembly further comprises a second stationary body;
the second fixing body is arranged on one side of the first fixing body in parallel, and the fixing groove is formed by enclosing the first fixing body, the second fixing body and the skin of a human body.
In an alternative embodiment of the method of the present invention,
the wound closure repair assembly further comprises an adjustment member;
both ends of the adjusting member are respectively connected with the first fixing body and the second fixing body, and the adjusting member is configured to be capable of adjusting a distance between the first fixing body and the second fixing body.
In an alternative embodiment of the method of the present invention,
the adjusting component comprises a first fixing piece, a second fixing piece and an adjusting belt;
the first fixing piece is arranged on the first fixing body, the second fixing piece is arranged on the second fixing body, and two ends of the adjusting belt are respectively connected with the first fixing piece and the second fixing piece in a sliding mode.
In an alternative embodiment of the method of the present invention,
first medical glue is arranged between the first fixing piece and the first fixing main body, and the first fixing piece is fixed on the first fixing main body through the first medical glue.
In an alternative embodiment of the method of the present invention,
the distractor adapter member comprises a traction band;
the traction belt is connected with the distractor adaptive membrane, and a wound contact layer is arranged on one surface, close to the skin of a human body, of the distractor adaptive membrane;
one side of the adaptive membrane of the distractor, which is far away from the skin of a human body, is sequentially provided with a liquid absorption layer and a barrier layer.
In an alternative embodiment of the method of the present invention,
the distractor adapting component further comprises second medical glue;
the second medical glue is arranged between the traction belt and the distractor adaptive membrane, and the traction belt is connected with the distractor adaptive membrane through the second medical glue.
In an alternative embodiment of the method of the present invention,
the first fixing body comprises a fixing part and an abutting part;
the fixing part is connected with the abutting part, the fixing part is fixed on the skin of a human body, and the fixing groove is formed between the abutting part and the skin of the human body.
In an alternative embodiment of the method of the present invention,
the wound closure repair assembly further comprises a third medical adhesive;
the fixing part is fixed on the skin of the human body through the third medical adhesive.
In a second aspect, the invention provides a process for preparing a stretch-former adaptive film, comprising the following steps:
dissolving polyurethane in an organic reagent, and stirring for 2-48h at room temperature to obtain a polyurethane solution with the mass fraction of 5-14 wt%;
setting the flow rate of the polyurethane solution to be 0.1-5ml/h, the voltage to be 15-45KV, and the receiving distance to be 10-30cm, so as to obtain a polyurethane polymer membrane with the aperture of 50-500 nm;
placing the polyurethane polymer film in a drying oven at 60-100 ℃ for heat treatment for 10-60min, reducing the pore diameter of the polyurethane polymer film to obtain a barrier layer, and bonding the barrier layer on the liquid absorption layer;
the polyurethane and the collagen are mixed according to the mass fraction as follows: 10: 1-1: 1, dissolving in hexafluoroisopropanol, and stirring at room temperature for 2-48h to obtain a solution with the total mass fraction of polyurethane and collagen of 5-14 wt%;
setting the flow rate of the polyurethane and collagen solution at 0.1-5ml/h, the voltage at 15-45KV, and the receiving distance at 10-30cm to obtain a wound contact layer with a pore diameter of 1-15um, and adhering the wound contact layer to the liquid absorption layer.
The invention provides a wound closure repair assembly, comprising: a first fixing body and a distractor adapter member; the first fixing body is used for being fixed on the skin of a human body, and a fixing groove is formed between the first fixing body and the skin of the human body in an enclosing mode; the distractor adapting component is provided with a distractor adapting film, and the distractor adapting component can extend into the fixing groove so as to enable the distractor adapting film to be attached to the skin wound of the human body. Through fixing first fixed main part on human skin, lead and stretch ware adaptation component and stretch into in the fixed slot that forms between first fixed main part and the human skin, make the leading ware adaptation membrane on leading ware adaptation component remove to the wound position, cover at human wound position, it is difficult to direct nursing on skin to have alleviated the wound nursing membrane that exists among the prior art, can only cover wound nursing membrane on leading ware, has the technical problem of infecting hidden danger.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a schematic view of an overall structure of a wound closure and repair assembly according to an embodiment of the present invention;
fig. 2 is a schematic structural view of a wound closure and repair assembly according to an embodiment of the present invention from a first perspective;
fig. 3 is a schematic structural diagram of a retractor adaptation film in a wound closure repair assembly according to an embodiment of the present invention.
Icon: 100-a first fixed body; 110-a stationary part; 120-an abutment; 200-a distractor adapter member; 210-a traction belt; 220-a distractor fitting membrane; 221-a wound contact layer; 222-a liquid-absorbing layer; 223-a barrier layer; 300-a second stationary body; 400-an adjustment member; 410-a first fixture; 420-a second fixture; 430-an adjustment band; 500-first medical glue; 600-second medical glue; 700-third medical glue.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or the orientations or positional relationships that the products of the present invention are conventionally placed in use, and are only used for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the devices or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," "third," and the like are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance.
Furthermore, the terms "horizontal", "vertical", "overhang" and the like do not imply that the components are required to be absolutely horizontal or overhang, but may be slightly inclined. For example, "horizontal" merely means that the direction is more horizontal than "vertical" and does not mean that the structure must be perfectly horizontal, but may be slightly inclined.
In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Some embodiments of the invention are described in detail below with reference to the accompanying drawings. The embodiments described below and the features of the embodiments can be combined with each other without conflict.
As shown in fig. 1, the present embodiment provides a wound closure and repair assembly, comprising: a first fixing body 100 and a distractor fitting member 200; the first fixing body 100 is used for being fixed on the skin of a human body, and a fixing groove is formed between the first fixing body 100 and the skin of the human body in an enclosing manner; the distractor fitting member 200 has a distractor fitting film 220, and the distractor fitting member 200 can be inserted into the fixing groove to make the distractor fitting film 220 fit on the skin wound of the human body.
Specifically, first fixed main part 100 laminates on human skin, it needs to be noted that, human wound position will be staggered in the laminating position of first fixed main part 100, first fixed main part 100 is fixed behind human skin, form the fixed slot between the extension limit that first fixed main part 100 top stretches out and the human skin, when needs nurse the wound position, stretch out ware adapter member 200 and stretch into in the fixed slot, remove along the fixed slot, slowly remove wound contact layer 221 to human wound position, make wound contact layer 221 laminate in human wound position.
The present embodiment provides a wound closure repair assembly, comprising: a first fixing body 100 and a distractor fitting member 200; the first fixing body 100 is used for being fixed on the skin of a human body, and a fixing groove is formed between the first fixing body 100 and the skin of the human body in an enclosing manner; the distractor fitting member 200 has a distractor fitting film 220, and the distractor fitting member 200 can be inserted into the fixing groove to make the distractor fitting film 220 fit on the skin wound of the human body. Through fixing first fixed main part 100 on human skin, stretch out in the fixed slot that forms between first fixed main part 100 and the human skin of tractive ware adaptation component 200, make the wound contact layer 221 on the tractive ware adaptation component 200 remove to the wound position, cover in human wound position, alleviated the wound nursing membrane that exists among the prior art and be difficult to directly nurse on the skin, only can cover the wound nursing membrane on the tractive ware, there is the technical problem of infection hidden danger.
On the basis of the above embodiment, in an alternative embodiment, as shown in fig. 2, wherein the first viewing angle is front view of the first fixing body 100, the wound closure and repair assembly provided in this embodiment further includes a second fixing body 300; the second fixing body 300 is disposed in parallel at one side of the first fixing body 100, and a fixing groove is defined between the first fixing body 100, the second fixing body 300 and the skin of the human body.
Specifically, the second fixing body 300 is attached to the skin of the human body, the second fixing body 300 is parallel to the first fixing body 100, and the positions of the first fixing body 100 and the second fixing body 300 can be selected according to specific conditions, so that the first fixing body 100 and the second fixing body 300 can be respectively located on two sides of the wound of the human body.
Fixing grooves are formed between the second fixing body 300 and the skin of the human body, and both sides of the distractor fitting member 200 move along the two fixing grooves to attach the wound contact layer 221 to the wound position of the human body.
In an alternative embodiment, the wound closure repair assembly further comprises an adjustment member 400; both ends of the adjustment member 400 are connected to the first and second fixing bodies 100 and 300, respectively, and the adjustment member 400 is configured to be able to adjust the interval between the first and second fixing bodies 100 and 300.
Specifically, one end of the adjustment member 400 is connected to the first fixing body 100, the other end of the adjustment member 400 is connected to the second fixing body 300, and the distance between the first fixing body 100 and the second fixing body 300 is adjusted by changing the overall length of the adjustment member 400 between the first fixing body 100 and the second fixing body 300.
In an alternative embodiment, the adjustment member 400 includes a first fixture 410, a second fixture 420, and an adjustment strap 430; the first fixing member 410 is disposed on the first fixing body 100, the second fixing member 420 is disposed on the second fixing body 300, and two ends of the traction belt 210 are slidably connected to the first fixing member 410 and the second fixing member 420, respectively.
Specifically, a first fixing member 410 and a second fixing member 420 are respectively disposed on the first fixing body 100 and the second fixing body 300, the first fixing member 410 is detachably connected to the first fixing body 100, the second fixing member 420 is detachably connected to the second fixing body 300, the first fixing member 410 is fixed to the first fixing body 100 after the position of the first fixing member 410 on the first fixing body 100 is determined, and similarly, the second fixing member 420 is fixed after the position of the second fixing member 420 is determined.
The adjusting strap 430 may be specifically configured as a strap, and the first fixing body 100 and the second fixing body 300 are fixing heads in the strap, and the fixing heads move on the strap in a single direction, and through tightening of the strap, the positions of the two fixing heads are adjusted, and the distance between the first fixing body 100 and the second fixing body 300 is changed.
In an alternative embodiment, a first medical adhesive 500 is disposed between the first fixing member 410 and the first fixing body 100, and the first fixing member 410 is fixed on the first fixing body 100 by the first medical adhesive 500.
Specifically, the first medical adhesive 500 is disposed between the first fixing member 410 and the first fixing body 100, and similarly, the first medical adhesive 500 is disposed between the second fixing member 420 and the second fixing body 300, and the first fixing member 410 is fixed on the first fixing body 100 by using the first medical adhesive 500, and is convenient to detach.
The wound closure and repair assembly provided by this embodiment changes the distance between the first fixing body 100 and the second fixing body 300 by adjusting the movement of the strap 430 on the first fixing member 410 and the second fixing member 420, thereby improving the applicability of the wound closure and repair assembly.
At present, when a wound nursing membrane is used for nursing in the use process of the distractor, gauze is often matched. The gauze wound nursing membrane has the advantage of being capable of rapidly absorbing wound exudate. But at the same time, there are also considerable disadvantages:
1. the gauze has large pores, and microorganisms can easily pass through the gauze, so that cross infection is caused.
2. Gauze has high permeability and may cause dehydration of the wound.
3. The gauze will stick to the wound surface and cause damage when replaced again.
The self-matching of the wound care film increases the unknown property of different operators in wound care, and further influences the full play of the skin repair effect of the retractor.
Based on the above embodiments, as shown in fig. 3, in an alternative embodiment, the present embodiment provides a distractor adapting member 200 in a wound closure repair assembly, comprising a traction band 210; the traction belt 210 is connected with a distractor adaptive membrane 220, and a wound contact layer 221 is arranged on one side, close to the skin of a human body, of the distractor adaptive membrane 220; the side of the retractor adaptation film 220 away from the human skin is provided with a liquid absorption layer 222 and a barrier layer 223 in sequence.
Specifically, the traction belt 210 is located on two sides of the distractor adaptive membrane 220, and when the medical stretcher is used, the medical staff holds the traction belt 210 to drive the distractor adaptive membrane 220 to move, so that the distractor adaptive membrane 220 is attached to a wound of a human body.
In an alternative embodiment, the distractor adapter member 200 further comprises a second medical glue 600; the second medical glue 600 is arranged between the traction belt 210 and the distractor adaptive membrane 220, and the traction belt 210 is connected with the distractor adaptive membrane 220 through the second medical glue 600.
Specifically, the second medical adhesive 600 is disposed between the traction band 210 and the distractor adaptive film 220, and the traction band 210 and the distractor adaptive film 220 are connected by the second medical adhesive 600.
In an alternative embodiment, the first fixing body 100 comprises a fixing portion 110 and an abutment 120; the fixing portion 110 is connected to the contact portion 120, the fixing portion 110 is fixed to the skin of the human body, and a fixing groove is formed between the contact portion 120 and the skin of the human body.
Specifically, the fixing portion 110 is attached to the skin of the human body, the abutting portion 120 is disposed on the top of the fixing portion 110, and after the fixing portion 110 is fixed, a gap is formed between the abutting portion 120 and the skin of the human body, so as to form a fixing groove.
In an alternative embodiment, the wound closure repair assembly further comprises a third medical glue 700; the fixing portion 110 is fixed on the skin of the human body by the third medical adhesive 700.
Specifically, the third medical adhesive 700 is arranged between the fixing portion 110 and the skin of the human body, and the fixing portion 110 is fixed on the skin of the human body through the third medical adhesive 700, so that the fixing portion 110 can be conveniently taken down from the skin of the human body.
The wound closed repair assembly provided by the embodiment drives the distractor adaptive membrane 220 to move through the traction belt 210, and the distractor adaptive membrane 220 moves to the position of a wound of a human body along the fixing groove to nurse the wound.
The preparation process of the adaptive membrane for the distractor provided by the embodiment comprises the following steps of: dissolving polyurethane in an organic reagent, and stirring for 2-48h at room temperature to obtain a polyurethane solution with the mass fraction of 5-14 wt%; setting the flow rate of the polyurethane solution to be 0.1-5ml/h, the voltage to be 15-45KV, and the receiving distance to be 10-30cm, so as to obtain a polyurethane polymer membrane with the aperture of 50-500 nm; placing the polyurethane polymer film in an oven at 60-100 ℃ for heat treatment for 10-60min, reducing the pore diameter of the polyurethane polymer film to obtain a barrier layer 223, and bonding the barrier layer 223 on the liquid absorption layer 222; the polyurethane and the collagen are mixed according to the mass fraction as follows: 10: 1-1: 1, dissolving in hexafluoroisopropanol, and stirring at room temperature for 2-48h to obtain a solution with the total mass fraction of polyurethane and collagen of 5-14 wt%; the flow rate of the polyurethane and collagen solution was set to 0.1-5ml/h, the voltage was 15-45KV, the receiving distance was 10-30cm, the wound contact layer 221 having a pore size of 1-15um was obtained, and the barrier layer 223 was adhered to the liquid absorbent layer 222.
Specifically, the central layer of the retractor is a liquid absorption layer 222 which is a macromolecule layer playing a role in absorbing and guiding liquid, the liquid absorption layer is polyurethane sponge, one surface of the liquid absorption layer 222 is coated with a layer of glue, and then polyurethane solution is spun on the liquid absorption layer through an electrostatic spinning technology.
The preparation process of the polyurethane solution comprises the following steps of dissolving polyurethane in an organic reagent, stirring for 2-48h at room temperature to obtain a solution with the mass fraction of the polyurethane being 5-14 wt%, wherein the organic solvent is one or a mixture of tetrahydrofuran, dimethyl sulfoxide, N-dimethylformamide, trichloromethane, dichloromethane and hexafluoroisopropanol.
The electrostatic spinning conditions of the polyurethane solution are that the flow rate of the spinning solution is 0.1-5ml/h, the voltage is 15-45KV, and the receiving distance is 10-30 cm.
Electrostatic spinning to obtain a compact polyurethane polymer membrane with the pore diameter of 50-500nm, and then putting the spun material in a drying oven with the temperature of 60-100 ℃ for heat treatment for 10-60min to further reduce the pore diameter of the compact polyurethane polymer membrane. The polyurethane polymer film obtained after the heat treatment is the barrier layer 223. The layer mainly plays a role in bacteria isolation and water resistance.
After a layer of glue is applied to the other side of the liquid absorbent layer 222, a solution of collagen-loaded polyurethane is spun through an electrospinning technique onto the layer, the collagen-loaded polyurethane having an active ingredient capable of promoting wound healing.
The preparation process of the solution comprises the following steps of proportioning polyurethane and collagen according to the mass fraction ratio: 10: 1-1: 1 is dissolved in hexafluoroisopropanol and stirred for 2 to 48 hours at room temperature to obtain a solution with the total mass fraction of polyurethane and collagen of 5 to 14 weight percent.
The electrostatic spinning conditions are that the flow rate of the spinning solution is 0.1-5ml/h, the voltage is 15-45KV, and the receiving distance is 10-30 cm.
The polymer membrane with the aperture of 1-15um is formed by electrostatic spinning, and the membrane is a wound contact layer 221, namely a part close to the skin, and mainly plays roles of preventing adhesion and promoting healing.
The specific preparation process can be as follows: coating a layer of glue on one surface of the liquid absorption layer 222, dissolving polyurethane in an organic reagent, and stirring at room temperature for 12 hours to obtain a solution with the mass fraction of the polyurethane being 10 wt%, wherein the organic solvent is tetrahydrofuran.
The electrostatic spinning conditions of the polyurethane solution were 1ml/h of the flow rate of the spinning solution, 30KV of the voltage and 15cm of the take-up distance.
And after spinning, the material is placed in an oven at 90 ℃ for heat treatment for 30min, and the aperture of the compact polyurethane polymer membrane is further reduced. The polyurethane polymer film obtained after the heat treatment serves as a barrier layer 223, and the barrier layer 223 is bonded to the liquid absorbent layer 222.
Polyurethane and collagen were mixed as 10: 1 is dissolved in hexafluoroisopropanol and stirred for 12 hours at room temperature to obtain a solution with the total mass fraction of polyurethane and collagen being 12 wt%.
The electrostatic spinning conditions were 0.5ml/h of spinning solution flow rate, 30KV of voltage and 15cm of take-up distance.
This layer is a wound contact layer 221, bonded to a liquid absorbent layer 222.
In addition, the polyurethane can also be dissolved in an organic reagent, and stirred for 12 hours at room temperature to obtain a solution with the mass fraction of the polyurethane being 8 wt%, wherein the organic solvent is a mixed solution of tetrahydrofuran and N, N-dimethylformamide, and the mass ratio of the two is 1: 3; the electrostatic spinning conditions of the polyurethane solution are that the flow rate of the spinning solution is 1ml/h, the voltage is 28KV, and the receiving distance is 15 cm; after spinning, the material is placed in an oven with the temperature of 80 ℃ for heat treatment for 40min, the aperture of the compact polyurethane polymer film is further reduced, and a barrier layer 223 is obtained; polyurethane and collagen were mixed as follows 5: the mixture ratio of 1 is dissolved in hexafluoroisopropanol, and the solution with the total mass fraction of polyurethane and collagen of 10 wt% is obtained after stirring for 12h at room temperature, and the electrostatic spinning conditions are that the flow rate of the spinning solution is 0.3ml/h, the voltage is 30KV, and the receiving distance is 15cm, so that the wound contact layer 221 is obtained.
For another example: dissolving polyurethane in an organic reagent, stirring for 12 hours at room temperature to obtain a solution with the mass fraction of the polyurethane being 12 wt%, wherein the organic solvent is a mixed solution of tetrahydrofuran and N, N-dimethylformamide, and the mass ratio of the tetrahydrofuran to the N, N-dimethylformamide is 1: 1; the electrostatic spinning conditions of the polyurethane solution are that the flow rate of the spinning solution is 1ml/h, the voltage is 30KV, and the receiving distance is 15 cm; and after spinning, the material is placed in an oven at 90 ℃ for heat treatment for 40min, and the aperture of the compact polyurethane polymer membrane is further reduced. The polyurethane polymer film obtained after the heat treatment is the barrier layer 223; polyurethane and collagen were mixed according to a ratio of 1: 1, dissolving in hexafluoroisopropanol, and stirring at room temperature for 12 hours to obtain a solution with the total mass fraction of polyurethane and collagen being 8 wt%; the electrostatic spinning conditions were such that the flow rate of the spinning solution was 0.1ml/h, the voltage was 30KV, and the reception distance was 15cm, to obtain the wound contact layer 221.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims (10)

1. A wound closure repair assembly, comprising: a first fixing body (100) and a distractor fitting member (200);
the first fixing body (100) is used for being fixed on the skin of a human body, and a fixing groove is formed between the first fixing body (100) and the skin of the human body in an enclosing mode;
the distractor adapting member (200) is provided with a distractor adapting film (220), and the distractor adapting member (200) can extend into the fixing groove so that the distractor adapting film (220) is attached to the skin wound of the human body.
2. The wound closure servicing assembly of claim 1,
the wound closure repair assembly further comprises a second stationary body (300);
the second fixing main body (300) is arranged on one side of the first fixing main body (100) in parallel, and the fixing grooves are formed by enclosing the first fixing main body (100), the second fixing main body (300) and the skin of a human body.
3. The wound closure servicing assembly of claim 2,
the wound closure repair assembly further comprises an adjustment member (400);
both ends of the adjusting member (400) are connected with the first fixing body (100) and the second fixing body (300), respectively, and the adjusting member (400) is configured to be able to adjust a distance between the first fixing body (100) and the second fixing body (300).
4. The wound closure servicing assembly of claim 3,
the adjusting member (400) comprises a first fixing piece (410), a second fixing piece (420) and an adjusting belt (430);
the first fixing piece (410) is arranged on the first fixing main body (100), the second fixing piece (420) is arranged on the second fixing main body (300), and two ends of the adjusting belt (430) are respectively connected with the first fixing piece (410) and the second fixing piece (420) in a sliding mode.
5. The wound closure servicing assembly of claim 4,
a first medical adhesive (500) is arranged between the first fixing piece (410) and the first fixing main body (100), and the first fixing piece (410) is fixed on the first fixing main body (100) through the first medical adhesive (500).
6. The wound closure servicing assembly of claim 1,
the distractor adaptor member (200) comprises a traction band (210);
the traction belt (210) is connected with the retractor adaptation film (220), and one side of the retractor adaptation film (220) close to the skin of a human body is provided with a wound contact layer (221);
the side of the adaptive membrane (220) of the distractor, which is far away from the skin of the human body, is sequentially provided with a liquid absorption layer (222) and a barrier layer (223).
7. The wound closure servicing assembly of claim 6,
the distractor adapter member (200) further comprises a second medical glue (600);
the second medical adhesive (600) is arranged between the traction belt (210) and the distractor adaptive membrane (220), and the traction belt (210) is connected with the distractor adaptive membrane (220) through the second medical adhesive (600).
8. The wound closure servicing assembly of claim 1,
the first fixing body (100) comprises a fixing portion (110) and an abutment portion (120);
the fixing part (110) is connected with the abutting part (120), the fixing part (110) is fixed on the skin of the human body, and the fixing groove is formed between the abutting part (120) and the skin of the human body.
9. The wound closure servicing assembly of claim 8,
the wound closure repair assembly further comprises a third medical glue (700);
the fixing part (110) is fixed on the skin of the human body through the third medical adhesive (700).
10. A preparation process of a stretcher adapting film is characterized by comprising the following steps:
dissolving polyurethane in an organic reagent, and stirring for 2-48h at room temperature to obtain a polyurethane solution with the mass fraction of 5-14 wt%;
setting the flow rate of the polyurethane solution to be 0.1-5ml/h, the voltage to be 15-45KV, and the receiving distance to be 10-30cm, so as to obtain a polyurethane polymer membrane with the aperture of 50-500 nm;
placing the polyurethane polymer film in an oven at 60-100 ℃ for heat treatment for 10-60min, reducing the pore diameter of the polyurethane polymer film to obtain a barrier layer (223), and bonding the barrier layer (223) on the liquid absorption layer (222);
the polyurethane and the collagen are mixed according to the mass fraction as follows: 10: 1-1: 1, dissolving in hexafluoroisopropanol, and stirring at room temperature for 2-48h to obtain a solution with the total mass fraction of polyurethane and collagen of 5-14 wt%;
setting the flow rate of the polyurethane and collagen solution at 0.1-5ml/h, the voltage at 15-45KV, and the reception distance at 10-30cm to obtain a wound contact layer (221) with a pore size of 1-15um, and adhering the wound contact layer (221) to the liquid absorbing layer (222).
CN202110150302.7A 2021-02-02 2021-02-02 Wound closure repairing assembly and preparation process of retractor adapting membrane Pending CN112773438A (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105169453A (en) * 2015-08-19 2015-12-23 欧阳晨曦 Preparation method of polyurethane composite material and composite material obtained by same
CN105342656A (en) * 2015-10-19 2016-02-24 张新平 Skin wound tension reducing device
CN106166305A (en) * 2016-06-27 2016-11-30 北京市创伤骨科研究所 A kind of broad-spectrum antiseptic type wound care film and preparation method thereof
CN109009288A (en) * 2018-09-18 2018-12-18 杭州吉为医疗科技有限公司 A kind of Skin stretching device
CN111012941A (en) * 2020-01-10 2020-04-17 中原工学院 Electrostatic spinning double-layer long-acting antibacterial medical dressing and preparation method thereof
CN215129372U (en) * 2021-02-02 2021-12-14 北京市创伤骨科研究所 Wound closure repair assembly

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105169453A (en) * 2015-08-19 2015-12-23 欧阳晨曦 Preparation method of polyurethane composite material and composite material obtained by same
CN105342656A (en) * 2015-10-19 2016-02-24 张新平 Skin wound tension reducing device
CN106166305A (en) * 2016-06-27 2016-11-30 北京市创伤骨科研究所 A kind of broad-spectrum antiseptic type wound care film and preparation method thereof
CN109009288A (en) * 2018-09-18 2018-12-18 杭州吉为医疗科技有限公司 A kind of Skin stretching device
CN111012941A (en) * 2020-01-10 2020-04-17 中原工学院 Electrostatic spinning double-layer long-acting antibacterial medical dressing and preparation method thereof
CN215129372U (en) * 2021-02-02 2021-12-14 北京市创伤骨科研究所 Wound closure repair assembly

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