CN112770748A - 异丁司特和干扰素-β的组合及其使用方法 - Google Patents

异丁司特和干扰素-β的组合及其使用方法 Download PDF

Info

Publication number
CN112770748A
CN112770748A CN201980065787.0A CN201980065787A CN112770748A CN 112770748 A CN112770748 A CN 112770748A CN 201980065787 A CN201980065787 A CN 201980065787A CN 112770748 A CN112770748 A CN 112770748A
Authority
CN
China
Prior art keywords
interferon
ibudilast
beta
day
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980065787.0A
Other languages
English (en)
Chinese (zh)
Inventor
松田和子
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medicinova Inc
Original Assignee
Medicinova Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicinova Inc filed Critical Medicinova Inc
Publication of CN112770748A publication Critical patent/CN112770748A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN201980065787.0A 2018-10-09 2019-10-08 异丁司特和干扰素-β的组合及其使用方法 Pending CN112770748A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862743449P 2018-10-09 2018-10-09
US62/743,449 2018-10-09
PCT/US2019/055167 WO2020076809A1 (en) 2018-10-09 2019-10-08 Combination of ibudilast and interferon-beta and methods of using same

Publications (1)

Publication Number Publication Date
CN112770748A true CN112770748A (zh) 2021-05-07

Family

ID=68343518

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980065787.0A Pending CN112770748A (zh) 2018-10-09 2019-10-08 异丁司特和干扰素-β的组合及其使用方法

Country Status (7)

Country Link
US (1) US10946071B2 (enExample)
EP (1) EP3863628B1 (enExample)
JP (1) JP2022504435A (enExample)
CN (1) CN112770748A (enExample)
CA (1) CA3115269A1 (enExample)
ES (1) ES2973119T3 (enExample)
WO (1) WO2020076809A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024528731A (ja) 2021-07-26 2024-07-30 メディシノバ・インコーポレイテッド 眼癌転移を予防するためのイブジラスト
US12042485B2 (en) 2021-10-07 2024-07-23 Medicinova, Inc. Methods of minimizing cancer metastasis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060093578A1 (en) * 2004-11-04 2006-05-04 Kyorin Pharmaceutical Co., Ltd. Method and composition for treating multiple sclerosis
CN101848712A (zh) * 2007-07-11 2010-09-29 美迪诺亚公司 用异丁地特治疗渐进性神经变性疾病
CN103260624A (zh) * 2010-12-07 2013-08-21 泰华制药工业有限公司 拉喹莫德用于在多发性硬化症患者中减少疲劳、改善功能状态和改善生活品质的用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8562198A (en) 1998-08-10 2000-03-06 Kyorin Pharmaceutical Co. Ltd. Remedies for multiple sclerosis
WO2006063048A2 (en) 2004-12-06 2006-06-15 Avigen, Inc. Ibudilast for treating neuropathic pain and associated syndromes
MX2008014971A (es) * 2006-05-24 2008-12-05 Serono Lab Regimen de cladribine para tratar esclerosis multiple.
EP2277515A1 (en) * 2009-07-10 2011-01-26 Sanofi-Aventis Use of the combination of teriflunomide and interferon beta for treating multiple sclerosis
ES2716865T3 (es) * 2011-02-18 2019-06-17 Scripps Research Inst Diferenciación dirigida de células precursoras de oligodendrocitos a un destino celular mielinizante

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060093578A1 (en) * 2004-11-04 2006-05-04 Kyorin Pharmaceutical Co., Ltd. Method and composition for treating multiple sclerosis
CN101848712A (zh) * 2007-07-11 2010-09-29 美迪诺亚公司 用异丁地特治疗渐进性神经变性疾病
CN103260624A (zh) * 2010-12-07 2013-08-21 泰华制药工业有限公司 拉喹莫德用于在多发性硬化症患者中减少疲劳、改善功能状态和改善生活品质的用途

Also Published As

Publication number Publication date
EP3863628A1 (en) 2021-08-18
ES2973119T3 (es) 2024-06-18
JP2022504435A (ja) 2022-01-13
WO2020076809A1 (en) 2020-04-16
US10946071B2 (en) 2021-03-16
CA3115269A1 (en) 2020-04-16
US20200108123A1 (en) 2020-04-09
EP3863628B1 (en) 2023-12-27

Similar Documents

Publication Publication Date Title
US20250073213A1 (en) Treatment of progressive neurodegenerative disease with ibudilast
CN112236140A (zh) 用于癌症治疗的使用异丁司特和第二药剂的方法和剂量方案
US10946071B2 (en) Combination of ibudilast and interferon-beta and methods of using same
CN118139619A (zh) 异丁司特以联合治疗方式用于治疗胶质母细胞瘤
CN112804999A (zh) 通过异丁司特治疗眼科疾病/病症或损伤的方法
HK1147953A (en) Treatment of progressive neurodegenerative disease with ibudilast

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20210507

WD01 Invention patent application deemed withdrawn after publication