CN112755120A - 一种治疗慢性咽炎的中药制剂及制备方法 - Google Patents

一种治疗慢性咽炎的中药制剂及制备方法 Download PDF

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CN112755120A
CN112755120A CN202110260032.5A CN202110260032A CN112755120A CN 112755120 A CN112755120 A CN 112755120A CN 202110260032 A CN202110260032 A CN 202110260032A CN 112755120 A CN112755120 A CN 112755120A
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李页瑞
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Heze Industrial Technology Research Institute
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Abstract

本发明公开了一种治疗慢性咽炎的中药制剂，制成所述中药制剂有效成分的原料组成及重量份数为：连翘18～48份、赤芍15～30份、牛蒡子10～25份、青果10～30份、蒲公英10～20份、射干10～25份、大青叶20～35份、陈皮10～20份、金银花30～35份、桔梗20～30份、麦冬20～30份、甘草10～20份、蜂蜜15～35份、西瓜皮30～50份、雪梨40～60份。优点在于：本发明中药制剂选用优质中药材科学配伍制成，具有活血通络、益阴散结、利咽止痛之功效，能够缓解并彻底根除慢性咽炎引起的咽喉干痛、异物感、发痒灼热等临床症状，疗效显著，安全无毒副作用，治疗总有效率高达97％。

Description

一种治疗慢性咽炎的中药制剂及制备方法
技术领域
本发明涉及中药制剂领域，具体是指一种治疗慢性咽炎的中药制剂及制备方法。
背景技术
慢性咽炎多因急性咽炎反复发作或治疗不彻底，以及邻近器官病灶刺激如鼻窦炎、扁桃体炎、鼻咽炎、气管炎等引起。烟酒过度、粉尘及有害气体刺激为常见病因。慢性咽炎病变主要在黏膜层，表现为咽部黏膜慢性充血，其血管周围有较多淋巴细胞浸润，也可见白细胞及浆细胞浸润，黏膜及黏膜下结缔组织增生，黏液腺可肥大，分泌功能亢进，黏液分泌增多。多见于成年人，病程长，易复发。慢性咽炎全身症状均不明显，而以局部症状为主。各型慢性咽炎症状大致相似，且多种多样，如咽部不适感、异物感、痒感、灼热感、干燥感或刺激感，还可由微痛等。主要由其分泌物及肥大的淋巴滤泡刺激所致；此外，还可有咳嗽、恶心等症状。慢性咽炎造成咳嗽、喘憋，导致的病理改变，进而导致出现的呼吸道疾病很多。咽喉部肿胀会影响食物的吞咽。咽喉部的炎症或其它病变刺激食管支配神经，引起膈肌痉挛，会出现呃逆、心下痞等症状。对于慢性咽炎的治疗，主要表现在消除各种致病因素，如戒除烟酒，改善工作环境，积极治疗鼻及鼻咽慢性炎性病灶及有关全身性疾病。同时，进行局部治疗，局部治疗常用复方硼砂溶液、呋喃西林溶液、2％硼酸液含漱，以保持口腔、口咽的清洁，或含服喉片，此外，还可用复方碘甘油、13％硝酸银溶液或10％弱蛋白银溶液涂抹咽部。上述治疗方法在治疗慢性咽炎上具有一定的疗效，但治疗效果不彻底，容易反复发作，使患者备受疾病折磨。因此，亟待研究一种治疗慢性咽炎的中药制剂及制备方法来解决上述提出的问题。
发明内容
本发明要解决的技术问题就是克服以上的技术缺陷，提供一种配制简易，提取方便，使用效果好的一种治疗慢性咽炎的中药制剂及制备方法。
为解决上述技术问题，本发明提供的技术方案为：一种治疗慢性咽炎的中药制剂，制成所述中药制剂有效成分的原料组成及重量份数为：连翘18～48份、赤芍15～30份、牛蒡子10～25份、青果10～30份、蒲公英10～20份、射干10～25份、大青叶20～35份、陈皮10～20份、金银花30～35份、桔梗20～30份、麦冬20～30份、甘草10～20份、蜂蜜15～35份、西瓜皮30～50份、雪梨40～60份。
进一步的，包括以下制备步骤：
S1：将原料中的西瓜皮和雪梨去皮、清洗干净后阴干，切成大小适宜的块备用；
S2：将原料中的连翘、赤芍、牛蒡子、青果、蒲公英、射干、大青叶、陈皮、金银花、桔梗、麦冬、甘草放入容器中，加入8～10倍量的70％的乙醇溶液，浸泡5h；加热煮沸，回流提取3h，过滤制得原液一；往滤渣中加入6～8倍量的70％的乙醇溶液，加热煮沸，回流提取2h，然后过滤制得原液二；再次往滤渣中加入4～6倍量的70％的乙醇溶液，加热煮沸，回流提取1h，然后过滤制得原液三；
S3：将S1步骤中处理好的西瓜皮和雪梨放入容器中，加入8～12倍量的蒸馏水，加热煮沸，提取1h，过滤制得原液四；
S4：将S2步骤中的原液一、原液二、原液三合并，合并后浓缩回收乙醇，将浓缩液制成在78℃环境下相对密度为1.20～1.30的稠膏，备用；
S5：将S3步骤中的原液四煮沸浓缩制得相对密度1.08～1.15的稠膏，备用；
S6：将S2、S3步骤中制得的产品混合，并且加入蜂蜜，搅拌均匀即制成治疗慢性咽炎的糖浆。
本发明所用中药的药性如下：
连翘：归经肺经，连翘具有良好的清热解毒作用，既能透热达表，又能清里热，连翘又能清心热，散结消瘰，清热，解毒，散结；
赤芍：味苦，性微寒，归肝经，具有清热凉血、散瘀止痛的功能，赤芍以清热凉血力胜，多用于咽喉肿痛、目赤肿痛；
牛蒡子：归肺、胃经，具有疏散风热，宣肺透疹，利咽散结，解毒消肿之功效，属于解表药中发散风热药
青果：归肺、胃经，其有清热解毒，利咽，生津之功效，主要用于咽喉肿痛，咳嗽痰黏，烦热口渴；
蒲公英：归肝、胃经，清热解毒，消肿散结，利尿通淋，用于疔疮肿毒，乳痈，瘰疠，目赤，咽痛，肺痈，肠痈，湿热黄疸，热淋涩痛。
射干：归肺经，为鸢尾科植物射干的干燥根茎，其味苦，性寒，有清热解毒，消痰，利咽之功效，常用于热毒痰火邰结，咽喉肿痛，痰涎壅盛，咳嗽气喘。
大青叶：归肝，心，胃，脾经，清热凉血、解心、胃热毒，抗菌，对金黄色葡萄球菌有较强的抑菌作用，对白喉杆菌有较好的抗菌作用；
陈皮：性味苦、辛，温，归肺、脾经，理气健脾，燥湿化痰，用于胸脘胀满，食少吐泻，咳嗽痰多；
金银花：性味甘，寒，归肺、心、胃经，清热解毒，凉散风热，用于痈肿疔疮，喉痹，丹毒，热毒血痢，风热感冒，温病发热；
桔梗：性味苦、辛，平，归肺经，宣肺，利咽，祛痰，排脓，用于咳嗽痰多，胸闷不畅，咽痛，音哑，肺痈吐脓，疮疡脓成不溃；
麦冬：性味甘，微苦，微寒，归心、肺、胃经，养阴生津，润肺清心。用于肺燥干咳。虚痨咳嗽，津伤口渴，心烦失眠，内热消渴，肠燥便秘，咽白喉；
甘草：性味甘，平，归心、肺、脾、胃经，补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
蜂蜜：性味甘，平，归肺、脾、大肠经，补中，润燥，止痛，解毒。用于脘腹虚痛，肺燥干咳，肠燥便秘；外治疮疡不敛，水火烫伤；
西瓜皮：性味甘、淡，寒，入心、胃经，清热解暑，泻热除烦，利尿。用于暑热烦渴、小便短赤、咽喉肿痛，或口舌生疮，浮肿等症；
雪梨：性味甘微酸，凉，入肺、胃经，生津，润燥，清热，化痰。治热病津伤烦渴，消渴，热咳，痰热惊狂，噎膈，便秘。
本发明与现有技术相比的优点在于：本发明中药制剂选用优质中药材科学配伍制成，具有活血通络、益阴散结、利咽止痛之功效，能够缓解并彻底根除慢性咽炎引起的咽喉干痛、异物感、发痒灼热等临床症状，疗效显著，安全无毒副作用，治疗总有效率高达97％。
具体实施方式
下面对本发明做进一步的详细说明。
一种治疗慢性咽炎的中药制剂，制成所述中药制剂有效成分的原料组成及重量份数为：连翘18～48份、赤芍15～30份、牛蒡子10～25份、青果10～30份、蒲公英10～20份、射干10～25份、大青叶20～35份、陈皮10～20份、金银花30～35份、桔梗20～30份、麦冬20～30份、甘草10～20份、蜂蜜15～35份、西瓜皮30～50份、雪梨40～60份。
进一步的，包括以下制备步骤：
S1：将原料中的西瓜皮和雪梨去皮、清洗干净后阴干，切成大小适宜的块备用；
S2：将原料中的连翘、赤芍、牛蒡子、青果、蒲公英、射干、大青叶、陈皮、金银花、桔梗、麦冬、甘草放入容器中，加入8～10倍量的70％的乙醇溶液，浸泡5h；加热煮沸，回流提取3h，过滤制得原液一；往滤渣中加入6～8倍量的70％的乙醇溶液，加热煮沸，回流提取2h，然后过滤制得原液二；再次往滤渣中加入4～6倍量的70％的乙醇溶液，加热煮沸，回流提取1h，然后过滤制得原液三；
S3：将S1步骤中处理好的西瓜皮和雪梨放入容器中，加入8～12倍量的蒸馏水，加热煮沸，提取1h，过滤制得原液四；
S4：将S2步骤中的原液一、原液二、原液三合并，合并后浓缩回收乙醇，将浓缩液制成在78℃环境下相对密度为1.20～1.30的稠膏，备用；
S5：将S3步骤中的原液四煮沸浓缩制得相对密度1.08～1.15的稠膏，备用；
S6：将S2、S3步骤中制得的产品混合，并且加入蜂蜜，搅拌均匀即制成治疗慢性咽炎的糖浆。
实施例一：一种治疗慢性咽炎的中药制剂，制成所述中药制剂有效成分的原料组成及重量份数为：连翘18份、赤芍15份、牛蒡子10份、青果10份、蒲公英10份、射干10份、大青叶20份、陈皮10份、金银花30份、桔梗20份、麦冬20份、甘草10份、蜂蜜15份、西瓜皮30份、雪梨40份。
实施例二：一种治疗慢性咽炎的中药制剂，制成所述中药制剂有效成分的原料组成及重量份数为：连翘48份、赤芍30份、牛蒡子25份、青果30份、蒲公英20份、射干25份、大青叶35份、陈皮20份、金银花35份、桔梗30份、麦冬30份、甘草20份、蜂蜜35份、西瓜皮50份、雪梨60份。
实施例三：一种治疗慢性咽炎的中药制剂，制成所述中药制剂有效成分的原料组成及重量份数为：连翘30份、赤芍23份、牛蒡子18份、青果20份、蒲公英15份、射干18份、大青叶27份、陈皮15份、金银花33份、桔梗25份、麦冬25份、甘草15份、蜂蜜25份、西瓜皮40份、雪梨50份。
以上对本发明及其实施方式进行了描述，这种描述没有限制性，总而言之如果本领域的普通技术人员受其启示，在不脱离本发明创造宗旨的情况下，不经创造性的设计出与该技术方案相似的实施例，均应属于本发明的保护范围。

Claims (2)

1.一种治疗慢性咽炎的中药制剂，其特征在于：制成所述中药制剂有效成分的原料组成及重量份数为：连翘18～48份、赤芍15～30份、牛蒡子10～25份、青果10～30份、蒲公英10～20份、射干10～25份、大青叶20～35份、陈皮10～20份、金银花30～35份、桔梗20～30份、麦冬20～30份、甘草10～20份、蜂蜜15～35份、西瓜皮30～50份、雪梨40～60份。
2.根据权利要求1所述的一种治疗慢性咽炎的中药制剂的制备方法，其特征在于：包括以下制备步骤：
S1：将原料中的西瓜皮和雪梨去皮、清洗干净后阴干，切成大小适宜的块备用；
S2：将原料中的连翘、赤芍、牛蒡子、青果、蒲公英、射干、大青叶、陈皮、金银花、桔梗、麦冬、甘草放入容器中，加入8～10倍量的70％的乙醇溶液，浸泡5h；加热煮沸，回流提取3h，过滤制得原液一；往滤渣中加入6～8倍量的70％的乙醇溶液，加热煮沸，回流提取2h，然后过滤制得原液二；再次往滤渣中加入4～6倍量的70％的乙醇溶液，加热煮沸，回流提取1h，然后过滤制得原液三；
S3：将S1步骤中处理好的西瓜皮和雪梨放入容器中，加入8～12倍量的蒸馏水，加热煮沸，提取1h，过滤制得原液四；
S4：将S2步骤中的原液一、原液二、原液三合并，合并后浓缩回收乙醇，将浓缩液制成在78℃环境下相对密度为1.20～1.30的稠膏，备用；
S5：将S3步骤中的原液四煮沸浓缩制得相对密度1.08～1.15的稠膏，备用；
S6：将S2、S3步骤中制得的产品混合，并且加入蜂蜜，搅拌均匀即制成治疗慢性咽炎的糖浆。
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