CN112741121A - Application of plant essential oil and perfume compound in preparation of sanitary product for inhibiting infection force of novel coronavirus - Google Patents

Application of plant essential oil and perfume compound in preparation of sanitary product for inhibiting infection force of novel coronavirus Download PDF

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CN112741121A
CN112741121A CN202110079465.0A CN202110079465A CN112741121A CN 112741121 A CN112741121 A CN 112741121A CN 202110079465 A CN202110079465 A CN 202110079465A CN 112741121 A CN112741121 A CN 112741121A
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essential oil
artemisia
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oil
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谢运昌
蔡爱华
霍华珍
李典鹏
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Guangxi Institute of Botany of CAS
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/18—Vapour or smoke emitting compositions with delayed or sustained release
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/20—Combustible or heat-generating compositions
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/06—Coniferophyta [gymnosperms], e.g. cypress
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/12—Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/22—Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/40—Liliopsida [monocotyledons]
    • A01N65/48—Zingiberaceae [Ginger family], e.g. ginger or galangal

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  • Agronomy & Crop Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
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Abstract

The invention discloses application of a series of plant essential oil and spice compounds in preparing a incense product for inhibiting the infectivity of novel coronavirus. The applicant shows through computer molecule docking experiments that the main compounds contained in the plant essential oil involved in the invention have stronger binding force with the S protein of the potential target of the new coronavirus, wherein the binding energy delta G of about 210 compounds and the S protein is less than or equal to-5.0 kcal/mol, and the S protein forms steric hindrance for the binding of ACE2 after being combined with the compounds. Moreover, the total amount of the components with the binding energy delta G less than or equal to-5.0 kcal/mol of the compound and the S protein in the essential oil exceeds 20 percent, so the plant essential oil has higher potential activity in the aspect of inhibiting SARS-CoV-2 from infecting host cells or self-replicating, can reduce or inhibit the infection power of coronavirus, and is expected to be applied to incense agents for blocking the epidemic situation of coronavirus.

Description

Application of plant essential oil and perfume compound in preparation of sanitary product for inhibiting infection force of novel coronavirus
Technical Field
The invention relates to a new application of plant essential oil, in particular to an application of plant essential oil and a spice compound in preparing a sanitary product for inhibiting the infectivity of a novel coronavirus.
Background
Currently, the new coronavirus infection disease (COVID-19) epidemic caused by the infection of the new coronavirus (SARS-CoV-2) has been listed as an emergent public health event of international concern by the world health organization.
In 2002-2003, Severe Acute Respiratory Syndrome (SARS) was caused by coronavirus SARS-CoV, and the mean fatality rate was about 11% when more than 80000 cases of clinical diagnosis were reported. SARS-CoV-2 is a virulent virus of the same type as SARS-CoV, and the source of the virus is unknown. Unlike SARS-CoV, SARS-CoV-2 virus infection is associated with severe damage to the respiratory system and intestinal inflammation, and clinical patients also present with multiple organ damage such as liver injury, nerve injury, myocardial injury, and kidney injury. Severe patients with the novel coronavirus pneumonia are frequently encountered with Cytokine Storm Syndrome (CSS).
Since the outbreak of novel coronavirus diseases, scientists research novel coronaviruses from structural biology, immunology and pharmacology, and no specific monomer compound medicine exists at present.
The novel coronavirus gene encodes a plurality of structural proteins, wherein S protein can be specifically combined with host receptors and is a key protein for virus to invade host susceptible cells. The search of new coronavirus resisting active compound is one important main battlefield for epidemic prevention and fighting. It is generally believed that when the binding energy of a compound to the S protein, AG.ltoreq.5.0 kcal/mol, indicates that the compound has a higher potential activity in inhibiting SARS-CoV-2 infection of host cells or self-replication.
The respiratory system of human body is distributed with more ACE2 (receptor of novel coronavirus), and the holding effect of virus stinging protein (S protein) on ACE2 of human body is the first relation of virus infection on human body. The virus is sleeved with a mouth sleeve to block the grasping effect of virus S protein and human ACE2, so that the virus can be kept out of the first line of defense, and the method is an epidemic prevention means with the lowest cost and the highest efficiency.
The plant essential oil is extracted from the unique aromatic substances of the plants, and is extracted from flowers, leaves, roots, barks, fruits or seeds of the herbaceous plants by distillation or squeezing. The plant essential oil has high volatility and small molecules, is easy to be absorbed by human body, can quickly permeate into internal organs of human body, can discharge redundant components out of human body, only needs a few minutes in the whole process, and the fragrance of the plant directly stimulates the secretion of pituitary gland, the secretion of enzymes, hormones and the like, thereby balancing the internal functions. The effects of vegetable essential oils are reported to include air purification, metabolism promotion, skin absorption promotion, fatigue relief, psychological stress relief, and the like. In addition, the invention patent with publication number CN108329999A discloses a method for extracting antrodia camphorata essential oil, and indicates that the essential oil has significant treatment effect on juvenile pseudomyopia when being applied to incense. However, no reports on the application of plant essential oil in hygienic products for reducing the infectivity of coronavirus are found at present.
Disclosure of Invention
The invention aims to solve the technical problem of providing the application of a series of plant essential oil and spice compounds in preparing sanitary products for inhibiting the infectivity of novel coronavirus.
The technical scheme of the invention is as follows: the application of plant essential oil in preparing sanitary articles for inhibiting the infectivity of novel coronavirus, wherein the plant essential oil is one or the combination of more than two of the following essential oils:
chinese torreya essential oil, bamboo cypress essential oil, fir essential oil, cedar essential oil, oriental arborvitae essential oil, sabia przewalskii essential oil, purple jade disk essential oil, magnolia bark essential oil, cassia bark essential oil, Huangguggui essential oil, Dinghu cinnamomum longepaniculatum essential oil, geranium essential oil, red fruit mountain pepper essential oil, nanmu essential oil, cow hoof asarum essential oil, tremella aurantium essential oil, betel leaf essential oil, leaf-changing pepper essential oil, saururus chinensis essential oil, yellow cow wood essential oil, abelmoschus chinensis essential oil, nanmu essential oil, leaf-leaved Murraya essential oil, Murraya koenigii essential oil, Senecio scandens, trigonella essential oil, Michelia nobilis essential oil, Stichopus japonicus essential oil, ash leaf Chinese angelica essential oil, Xinjiang ligusticum essential oil, Ligusticum wallichii essential oil, Ligusticum chuanxiong essential oil, Benzonum tenuii essential oil, sandalwood essential oil, rhododendron essential oil, leaf essential oil, fragrant rhododendron leaf essential oil, fragrant, Green rhododendron essential oil, axillary rhododendron essential oil, spikenard essential oil, dahua spikenard essential oil, perlescent fragrant green essential oil, artemisia annua essential oil, artemisia anomala essential oil, artemisia desertorum essential oil, artemisia selengensis essential oil, artemisia argyi essential oil, artemisia halodendron essential oil, artemisia alba essential oil, artemisia nigra essential oil, artemisia mollissima essential oil, artemisia alba essential oil, artemisia scoparia essential oil, artemisia argyi essential oil, artemisia apiacea essential oil, isoquercus angustifolia essential oil, artemisia sphaerocephala essential oil, artemisia rupestris essential oil, atractylodes macrocephala essential oil, atractylodes lancea essential oil, atractylodes macrocephala essential oil, galingale essential oil, galium small blumea essential oil, chrysanthemum flower essential oil, lysimachia foenum-graecum essential oil, melissa essential oil, primrose essential oil, vitex negundo essential oil, vitex essential oil, agastache rugosus essential oil, elsholly essential oil, elsholtzia essence oil, alpine essential oil, alpinia galangal, Turmeric essential oil, zedoary essential oil, ginger essential oil and calamus essential oil.
The applicant carries out molecular docking on main compounds contained in the plant essential oil (made in China) and S protein which is a potential target of the new coronavirus through a computer molecular docking technology, and docking results show that about 210 compounds in the main compounds contained in the essential oil have strong binding force with the S protein, the binding energy delta G is less than or equal to-5.0 kcal/mol, and the S protein forms steric hindrance on the binding of ACE2 after being bound with the compounds. Moreover, the total amount of the components with the binding energy delta G less than or equal to-5.0 kcal/mol of the compound and the S protein in the essential oil exceeds 20 percent, so the plant essential oil has higher potential activity in the aspect of inhibiting SARS-CoV-2 from infecting host cells or self-replicating, and can reduce or inhibit the infection of coronavirus.
In the above technical solution, the plant essential oil is preferably one or a combination of two or more of the following essential oils: folium et cacumen Murrayae essential oil, Japanese cedar wood essential oil, Atractylodes macrocephala essential oil, green sea Cuculus Rhododendri essential oil, cortex Cinnamomi Japonici essential oil, Curcuma rhizome essential oil, herba Artemisiae Annuae essential oil, herba Pteridis Davidii essential oil, herba Artemisiae Halodendri essential oil, folium Artemisiae Annuae essential oil, herba Artemisiae Ordosicae essential oil, rhizoma Atractylodis essential oil, folium Cudraniae essential oil, Curcumae rhizoma essential oil, folium Artemisiae Argyi essential oil, radix Curcumae essential oil, radix et rhizoma Wenyujin Concisa essential oil, herba Viticis Cannabifoliae essential oil, lignum Xanthii essential oil, herba Cudraniae Lanceolatae essential oil, radix et rhizoma Nardostachyos essential oil, herba Artemisiae Annuae essential oil, ramulus et folium Pterospermi Alternantherae essential oil, herba Asteris-idaeae essential oil, herba Ainsliaeae Yunnanensis essential oil, herba Artemisiae Halodendri essential oil, herba Artemisiae Halodendron salt, herba Artemisiae Annuae essential oil, chinese torreya essential oil, red fruit mountain pepper essential oil, triangle olive essential oil, stichopus japonicus essential oil, Dinghu Cinnamomum camphora essential oil and rhododendron anthopogonoides essential oil. The applicant has found that the total amount of components having a.DELTA.G.ltoreq.5.5 kcal/mol in these essential oils of plants exceeds 10% and the total amount of components having a.DELTA.G.ltoreq.5.0 kcal/mol exceeds 20%, is better able to reduce the infectivity of the novel coronavirus.
In the technical scheme, the sanitary product is a fumigant, and specifically can be a liquid fumigant or a solid fumigant.
The invention also provides a hygienic product capable of inhibiting the infection power of the novel coronavirus, which contains 0.1-2.0% of plant essential oil in percentage by weight, wherein the plant essential oil is one or the combination of more than two of the following compounds:
chinese torreya essential oil, bamboo cypress essential oil, fir essential oil, cedar essential oil, oriental arborvitae essential oil, sabia przewalskii essential oil, purple jade disk essential oil, magnolia bark essential oil, cassia bark essential oil, Huangguggui essential oil, Dinghu cinnamomum longepaniculatum essential oil, geranium essential oil, red fruit mountain pepper essential oil, nanmu essential oil, cow hoof asarum essential oil, tremella aurantium essential oil, betel leaf essential oil, leaf-changing pepper essential oil, saururus chinensis essential oil, yellow cow wood essential oil, abelmoschus chinensis essential oil, nanmu essential oil, leaf-leaved Murraya essential oil, Murraya koenigii essential oil, Senecio scandens, trigonella essential oil, Michelia nobilis essential oil, Stichopus japonicus essential oil, ash leaf Chinese angelica essential oil, Xinjiang ligusticum essential oil, Ligusticum wallichii essential oil, Ligusticum chuanxiong essential oil, Benzonum tenuii essential oil, sandalwood essential oil, rhododendron essential oil, leaf essential oil, fragrant rhododendron leaf essential oil, fragrant, Green rhododendron essential oil, axillary rhododendron essential oil, spikenard essential oil, dahua spikenard essential oil, perlescent fragrant green essential oil, artemisia annua essential oil, artemisia anomala essential oil, artemisia desertorum essential oil, artemisia selengensis essential oil, artemisia argyi essential oil, artemisia halodendron essential oil, artemisia alba essential oil, artemisia nigra essential oil, artemisia mollissima essential oil, artemisia alba essential oil, artemisia scoparia essential oil, artemisia argyi essential oil, artemisia apiacea essential oil, isoquercus angustifolia essential oil, artemisia sphaerocephala essential oil, artemisia rupestris essential oil, atractylodes macrocephala essential oil, atractylodes lancea essential oil, atractylodes macrocephala essential oil, galingale essential oil, galium small blumea essential oil, chrysanthemum flower essential oil, lysimachia foenum-graecum essential oil, melissa essential oil, primrose essential oil, vitex negundo essential oil, vitex essential oil, agastache rugosus essential oil, elsholly essential oil, elsholtzia essence oil, alpine essential oil, alpinia galangal, Turmeric essential oil, zedoary essential oil, ginger essential oil and calamus essential oil.
The sanitary article is a fumigant, which may be a liquid fumigant or a solid fumigant, and is prepared by a technique known in the art. Wherein, the solid incensing agent can be applied through an electronic incense burner, the liquid incensing agent can be applied through a cold incensing instrument, an incense machine, an incense expanding machine, an atomization instrument, a humidifier, incense expanding stones, incense expanding wood or rattans and the like, or can be applied through an electric incense device, or the plant essential oil can be directly used as a sanitary article to be applied to the incense expanding stones, the incense expanding wood, a mask, fabrics, paper towels and indoor environment.
In order to facilitate the application of equipment, the plant essential oil can be dissolved by a common fumigating solvent and then prepared into a liquid fumigating agent. The general solvent for incense comprises any one or more of ethanol, propylene glycol, 3-methoxy-3-methyl butanol (MMB), dipropylene glycol monomethyl ether (DPM), dipropylene glycol (DPG), diethylene glycol dibutyl ether, triethylene glycol butyl ether, tetraethylene glycol butyl ether and the like, or any one or more of the above components and water. The common solvents for incense also include isododecane (isopar G) and/or isohexadecane (isopar M), etc.
Preferably, the invention provides a water-based electrothermal liquid incense agent which is nonflammable, stable in volatilization, and capable of using an electrothermal incense device to expand incense and reducing the infection force of coronavirus, and the water-based electrothermal liquid incense agent comprises the following components: 0.1-2.0% of plant essential oil, 45-80% of alcohol ether solvent, 0-0.6% of antioxidant and the balance of deionized water. Wherein, the alcohol ether solvent is preferably any one or more of ethanol, diethylene glycol butyl ether, triethylene glycol butyl ether and tetraethylene glycol butyl ether. The antioxidant is any one selected from BHT, BHA and TBHQ, and the content of the antioxidant is preferably 0.1-0.4%.
The method for preparing the water-based electrothermal liquid fumigant capable of reducing the infectivity of coronavirus comprises the following steps: weighing the components according to the formula, firstly mixing the plant essential oil, the alcohol ether solvent and the antioxidant uniformly, then adding the deionized water, and mixing uniformly to obtain the plant essential oil-alcohol ether-antioxidant water-based oil. For convenient application, the resulting fumigant is typically packaged for use in a container capable of being sprayed or squeezed out.
The application further provides application of the perfume compound in the plant essential oil in preparing a sanitary product for inhibiting the infectivity of the novel coronavirus, wherein the perfume compound is one or the combination of more than two of the following compounds:
arthrotriene, narcotine, curcumenol, Ruthene, arylturmerone, atractylone, beta-guaiene, guaiol, alpha-GUYUENE, 16-kauranol, arhat pinene, alantolactone, amygdaline, alpha-bourbonene, Acorus calamus alkene, alpha-cedrene, steviol, eucalyptol, turmerone, curcuma aromatica, alpha-turmerone, beta-turmerone, narcole, allobergene, alpha-bisabolol, beta-bourbonene, chamazulene, artemisone, guaiarene, gamma-GUYUYURENE, norlapachol, buveratol, beta-cedrene, linalool, beta-buxene, beta-curcumene, arylgingerol, maxatol, nardostachyone, pimpinene, guanadine, azulene, shogazeulol, shogazeruminolone, shogaol, valepotamone, zingiberene, butrene, bergenin, Beta-juniperol, germacrone, gamma-guaiene, alpha-guaiacol, beta-cedrene, farrerone, thujene, beta-patchouline, patchoulenone, angelicin, curcumene, beta-germacrone, alpha-bisabolol oxide B, cedrol, beta-piperylene, alpha-curcumene, gamma-curcumene, curdione, cyperone, Trans-farnesyl acetate, delta-guaiene, isocalamenediol, trumpet alcohol, beta-pimelene, hordeone, apiadiene, beta-apiene, (-) -delta-apiene, (+) -delta-apiene, apigenin, hanthujol, (+) -delta-juniperone, alpha-juniperol, gamma-juniperol, Costunolide, curzerene, cumulene, artrene, beta-eudesmol, (E) -beta-farnesene, gamma-cedrene, delta-ylaurene, narazulene, alpha-apiene, sesquiphellandrene, caryophyllene, alpha-damascone, 4-cadinen-7-ol, alpha-cadinene, beta-cadinene, tau-cadinene, capillone, copaikene, (-) -beta-piperlongebene, phellandrene, geranylgeranone, cadinene, nocardiene, phellodendron, parsley methyl ether, beta-santalene, (E) -beta-santalene, kaempferide, gamma-apirene, thujene, orcinol, thujopside, alpha-ylarene, caladiene, alpha-canarydiene, beta-santalene, alpha-kaempferine, beta-kaempferine, beta, Apigenin, betulin, gamma-cadinene, delta-junenol, capillin, alpha-cubebene, cubebinol, xanthone isomer, dihydrofarnesol, eudesmol, lawyenol, alpha-elemene, (+) -beta-ylaurene, gamma-ylaurene, delta-patchoulene, (+) -alpha-santalene, torreyol, elecampane ketene, aristolenone, dehydrocalamenene, carol, piperitol, alpha-thujoanone, bucindoxyl, (Z) -beta-farnesene, (-) -alpha-cedrene, humulol, ligustilide, elenol, gamma-elemene, methyl piperitol \ estragole, ylarene, myristyl ether, neocnidide, hydroquinone dimethyl ether, gamma-patchouline, dihydromyrcene, alpha-piperonyl alcohol, dihydromyrtilbene, dihydromyrtilben-methyl ether, alpha-linalol, beta-isol, dihydromyrtilben, dihydromyrcene, alpha-santalene, beta-santalol, (+) -beta-thujone, xanthone (zerumbone), alpha-ylang-oleyl, beta-asarone, ascaridole, bergaptene, (-) -2-carene, piperitol, bucindolone, eugenol, germacrene, beta-guyucene, longifolene, alpha-patchoulene, (Z) -alpha-santalol, saussurea lactone, asarone, chamigrene, dehydroelsholtzone, delta-elemene, gamma-elemene, elemenol, elsholtzone, luprene, methyl salicylate, patchouli alcohol and ageratum essence.
The above-mentioned perfume compounds can be used to prepare liquid or solid incentives in the same manner as described above.
The applicant finds that the main compounds contained in the plant essential oil related to the invention have stronger binding force with a new coronavirus potential target S protein through a computer molecular docking technology, wherein the binding energy delta G of about 210 compounds and the S protein is less than or equal to-5.0 kcal/mol, and the S protein forms steric hindrance for the binding of ACE2 after being bound with the compounds. Moreover, the total amount of the components with the binding energy delta G of less than or equal to-5.0 kcal/mol of the compounds and the S protein in the essential oil exceeds 20 percent, so the plant essential oil has higher potential activity in the aspect of inhibiting SARS-CoV-2 from infecting host cells or self-replicating, can reduce or inhibit the infection force of the coronavirus, can generate the effect on the virus without being absorbed and distributed by a human body, and is expected to be applied to the incense agent for blocking the epidemic situation of the coronavirus.
Detailed Description
The present invention will be better understood from the following detailed description of specific examples, which should not be construed as limiting the scope of the present invention.
The percentages referred to in the following examples are percentages by weight.
Example 1: molecular docking of plant essential oils and major flavor compounds contained therein with the S protein, a potential target of new coronaviruses
The 3D structure file in the sdf format of the botanical fragrance compound was downloaded from the website https:// pubchem.ncbi.nlm.nih.gov/which is supported by the American national health institute and which is responsible for maintenance by the American national center for Biotechnology information. The 3D conformation was then optimized with the avagadro software and saved in pdb format. And finally, distributing related charges through Autodock Tools, automatically setting a twistable key, and exporting the twistable key into a pdbqt format file.
The S protein adopts a pdbqt format file downloaded from a new coronavirus drug target structure information sharing platform system in Qingdao ocean science and technical pilot national key laboratories, and autodock vina is operated to carry out molecular docking, wherein docking parameters are as follows:
center_x＝-32.81
center_y＝25.66
center_z＝4.79
size_x＝23
size_y＝21
size_z＝21
seed＝2020
energy_range＝5
exhaustiveness＝400
num_modes＝20
the docking results are shown in tables 1 and 2.
TABLE 1 fragrance Compounds with binding energies AG ≦ 5.0kcal/mol
Figure BDA0002908586900000051
Figure BDA0002908586900000061
Figure BDA0002908586900000071
Figure BDA0002908586900000081
Figure BDA0002908586900000091
Figure BDA0002908586900000101
TABLE 2 main chemical components and contents of plant essential oil and S protein having strong binding force
Figure BDA0002908586900000102
Figure BDA0002908586900000111
Figure BDA0002908586900000121
Figure BDA0002908586900000131
Figure BDA0002908586900000141
Note: the main chemical components and the contents of the essential oils in the table are derived from the prior literature, wherein the content unit is weight percentage.
The plants and parts extracted from the essential oils shown in Table 2 are shown in Table 3 below.
Table 3.
Figure BDA0002908586900000151
Figure BDA0002908586900000161
In Table 2 there are 51 plant essential oils having a total amount of AG ≦ -5.5kcal/mol ingredient of more than 10% and a total amount of AG ≦ -5.0kcal/mol ingredient of more than 20%, which are listed in Table 4 below.
TABLE 4 plant essential oils with strong binding to S protein and rich chemical content are preferred
Figure BDA0002908586900000162
Figure BDA0002908586900000171
Figure BDA0002908586900000181
Example 2: liquid fumigant (leaf murraya paniculata branch and leaf essential oil base)
Quantitatively weighing 1.43 percent of Murraya paniculata branch and leaf essential oil and 98.57 percent of medical alcohol, mixing and stirring uniformly to obtain a semi-finished product. Filtering the semi-finished product, filling, and making into final product by hand-pressing spray device.
Example 3: liquid fumigant (ginger sealwort oil base)
Quantitatively weighing 1.33% of turmeric essential oil and 98.67% of medical alcohol, mixing and uniformly stirring to obtain the turmeric essential oil.
Example 4: liquid incense agent (fir essential oil base)
Quantitatively weighing 1.33% of fir wood essential oil and 98.67% of medical alcohol, mixing and uniformly stirring to obtain the Chinese fir wood essential oil.
Example 5: liquid fumigant (cedar essential oil base)
Quantitatively weighing 1.33% of cedar essential oil and 98.67% of medical alcohol, mixing and uniformly stirring to obtain the cedar essential oil.
Example 6: liquid fumigant (triangle olive branch and leaf essential oil base)
Quantitatively weighing 1.43% of the branch and leaf essential oil of the Canarium album and 98.57% of medical alcohol, mixing and stirring uniformly to obtain the product.
Example 7: liquid fumigant (south atractylodes essential oil base)
Quantitatively weighing 1.25% of rhizoma atractylodis sinensis essential oil and 98.75% of medical alcohol, mixing and uniformly stirring to obtain the rhizoma atractylodis sinensis essential oil.
Example 8: liquid fumigant (ginger essential oil base)
Quantitatively weighing 1.67% of ginger essential oil and 98.33% of medical alcohol, mixing and uniformly stirring to obtain the ginger essential oil.
Example 9: liquid fumigant (wrinkled giant hyssop essence oil base)
Quantitatively weighing 1.25% of ageratum essential oil and 98.75% of medical alcohol, mixing and uniformly stirring to obtain the product.
Example 10: liquid fumigant (golden earring whole grass essential oil base)
Quantitatively weighing 1.33% of the golden earring whole herb essential oil and 98.67% of medical alcohol, mixing and uniformly stirring to obtain the golden earring whole herb essential oil.
Example 11: liquid stacte (Bull wood branch and leaf essential oil base)
Quantitatively weighing 1.79% of the yellow bull branch and leaf essential oil and 98.21% of medical alcohol, mixing and uniformly stirring to obtain the yellow bull branch and leaf essential oil.
Example 12: liquid fumigant (Dinghu fishing camphor branches and leaves essential oil base)
Quantitatively weighing 1.79% of branch and leaf essential oil of Tinghu Cinnamomum camphora and 98.21% of medical alcohol, mixing and stirring uniformly to obtain the product.
Example 13: liquid incense (lantana essential oil base)
Quantitatively weighing 1.79% of lantana camara essential oil and 98.21% of medical alcohol, mixing and uniformly stirring to obtain the lantana camara.
Example 14: liquid fumigant (Vitex essential oil base)
Quantitatively weighing 1.79% of vitex negundo oil and 98.21% of medical alcohol, mixing and uniformly stirring to obtain the product.
Example 15: liquid fumigant (essential oil base of branches and leaves of cryptomeria fortunei)
Quantitatively weighing 1.79% of the cedar branch and leaf essential oil and 98.21% of medical alcohol, mixing and uniformly stirring to obtain the cedar branch and leaf essential oil.
Example 16: liquid stacte (Pearl light fragrant green essential oil base)
Quantitatively weighing 1.79% of pearlescent azurin essential oil and 98.21% of medical alcohol, mixing and uniformly stirring to obtain the pearlescent azurin essential oil.
Example 17: liquid fumigant (Artemisia annua essential oil base)
Quantitatively weighing 1.79% of artemisia annua essential oil and 98.21% of medical alcohol, and mixing and uniformly stirring to obtain the artemisia annua essential oil.
Example 18: liquid fumigant (zedoary essential oil base)
Quantitatively weighing 1.79% of zedoary turmeric oil and 98.21% of medical alcohol, mixing and uniformly stirring to obtain the traditional Chinese medicine.
Example 19: liquid fumigant (Wenyu gold essential oil base)
Quantitatively weighing 1.79% of curcuma wenyujin essential oil and 98.21% of medical alcohol, mixing and uniformly stirring to obtain the finished product.
Example 20: liquid incense (white atractylodes essential oil base)
Quantitatively weighing 1.79% of white atractylodes rhizome essential oil and 98.21% of medical alcohol, and mixing and uniformly stirring to obtain the traditional Chinese medicine.
Example 21: liquid fumigant (leaf and branch of Murraya koenigii essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of Murraya pterocarpa branches and leaves essential oil and 68.00% of diethylene glycol monobutyl ether, mixing and uniformly stirring, adding 30.00% of deionized water, and uniformly stirring to obtain the composition.
Example 22: liquid fumigant (turmeric essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of turmeric essential oil and 68.00% of diethylene glycol monobutyl ether, mixing and uniformly stirring, adding 30.00% of deionized water, and uniformly stirring to obtain the turmeric essential oil-containing emulsion.
Example 23: liquid fumigant (fir essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of fir wood essential oil and 68.00% of diethylene glycol monobutyl ether, mixing and uniformly stirring, adding 30.00% of deionized water, and uniformly stirring to obtain the Chinese fir wood adhesive.
Example 24: liquid fumigant (cedar essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of cedar essential oil and 68.00% of diethylene glycol monobutyl ether, mixing and uniformly stirring, adding 30.00% of deionized water, and uniformly stirring to obtain the cedar essential oil-containing paint.
Example 25: liquid fumigant (triangular olive branch and leaf essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of branch and leaf essential oil of Canarium triangularis, 68.00% of diethylene glycol monobutyl ether, mixing and stirring uniformly, adding 30.00% of deionized water, and stirring uniformly to obtain the product.
Example 26: liquid fumigant (south atractylodes essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of rhizoma atractylodis sinensis essential oil and 68.00% of diethylene glycol monobutyl ether, mixing and uniformly stirring, adding 30.00% of deionized water, and uniformly stirring to obtain the rhizoma atractylodis sinensis essence.
Example 27: liquid fumigant (ginger essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of ginger essential oil and 68.00% of diethylene glycol monobutyl ether, mixing and uniformly stirring, adding 30.00% of deionized water, and uniformly stirring to obtain the ginger essential oil.
Example 28: liquid fumigant (wrinkled giant hyssop essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of agastache rugosus essential oil and 68.00% of diethylene glycol monobutyl ether, mixing and uniformly stirring, adding 30.00% of deionized water, and uniformly stirring to obtain the agastache rugosus essential oil.
Example 29: liquid fumigant (golden earring whole plant essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of the golden earring whole herb essential oil and 68.00% of diethylene glycol monobutyl ether, mixing and uniformly stirring, adding 30.00% of deionized water, and uniformly stirring to obtain the feed additive.
Example 30: liquid fumigant (Tinospora tabacum branch and leaf essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of the yellow bull wood branch and leaf essential oil and 68.00% of diethylene glycol monobutyl ether, mixing and uniformly stirring, adding 30.00% of deionized water, and uniformly stirring to obtain the yellow bull wood essential oil.
Example 31: liquid fumigant (Dinghu fishing camphor branch and leaf essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of the branch and leaf essential oil of the Tinghu Cinnamomum camphora and 68.00% of diethylene glycol monobutyl ether, mixing and uniformly stirring, adding 30.00% of deionized water, and then uniformly stirring to obtain the product.
Example 32: liquid incense (lantana camara essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of lantana camara essential oil and 68.00% of diethylene glycol monobutyl ether, mixing and uniformly stirring, adding 30.00% of deionized water, and uniformly stirring to obtain the final product.
Example 33: liquid fumigant (Vitex essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of vitex essential oil and 68.00% of diethylene glycol monobutyl ether, mixing and uniformly stirring, adding 30.00% of deionized water, and uniformly stirring to obtain the product.
Example 34: liquid fumigant (Vitex agnus-leaf essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of the Vitex agnus-castus branch and leaf essential oil and 68.00% of diethylene glycol butyl ether, mixing and uniformly stirring, adding 30.00% of deionized water, and uniformly stirring to obtain the final product.
Example 35: liquid fumigant (Cryptomeria japonica branch and leaf essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of cedar branch and leaf essential oil and 68.00% of diethylene glycol monobutyl ether, mixing and uniformly stirring, adding 30.00% of deionized water, and uniformly stirring to obtain the cedar leaf essential oil.
Example 36: liquid fumigant (Pearl light green essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of pearlescent azurin essential oil and 68.00% of diethylene glycol monobutyl ether, mixing and uniformly stirring, adding 30.00% of deionized water, and uniformly stirring to obtain the pearlescent azurin essential oil.
Example 37: liquid fumigant (Artemisia annua essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of artemisia annua essential oil and 68.00% of diethylene glycol monobutyl ether, mixing and uniformly stirring, adding 30.00% of deionized water, and uniformly stirring to obtain the artemisia annua essential oil-containing emulsion.
Example 38: liquid fumigant (zedoary turmeric oil-alcohol ether-water base)
Quantitatively weighing 2.00% of zedoary turmeric oil and 68.00% of diethylene glycol monobutyl ether, mixing and stirring uniformly, adding 30.00% of deionized water, and stirring uniformly to obtain the final product.
Example 39: liquid fumigant (Wintery root essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of curcuma wenyujin essential oil and 68.00% of diethylene glycol monobutyl ether, mixing and uniformly stirring, adding 30.00% of deionized water, and uniformly stirring to obtain the finished product.
Example 40: liquid fumigant (white atractylodes rhizome essential oil-alcohol ether-water base)
Quantitatively weighing 2.00% of white atractylodes rhizome essential oil and 68.00% of diethylene glycol monobutyl ether, mixing and uniformly stirring, adding 30.00% of deionized water, and uniformly stirring to obtain the traditional Chinese medicine composition.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any simple modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention are within the scope of the technical solution of the present invention.

Claims (5)

1. The application of plant essential oil in preparing sanitary articles for inhibiting the infectivity of novel coronavirus, wherein the plant essential oil is one or the combination of more than two of the following essential oils:
chinese torreya essential oil, bamboo cypress essential oil, fir essential oil, cedar essential oil, oriental arborvitae essential oil, sabia przewalskii essential oil, purple jade disk essential oil, magnolia bark essential oil, cassia bark essential oil, Huangguggui essential oil, Dinghu cinnamomum longepaniculatum essential oil, geranium essential oil, red fruit mountain pepper essential oil, nanmu essential oil, cow hoof asarum essential oil, tremella aurantium essential oil, betel leaf essential oil, leaf-changing pepper essential oil, saururus chinensis essential oil, yellow cow wood essential oil, abelmoschus chinensis essential oil, nanmu essential oil, leaf-leaved Murraya essential oil, Murraya koenigii essential oil, Senecio scandens, trigonella essential oil, Michelia nobilis essential oil, Stichopus japonicus essential oil, ash leaf Chinese angelica essential oil, Xinjiang ligusticum essential oil, Ligusticum wallichii essential oil, Ligusticum chuanxiong essential oil, Benzonum tenuii essential oil, sandalwood essential oil, rhododendron essential oil, leaf essential oil, fragrant rhododendron leaf essential oil, fragrant, Green rhododendron essential oil, axillary rhododendron essential oil, spikenard essential oil, dahua spikenard essential oil, perlescent fragrant green essential oil, artemisia annua essential oil, artemisia anomala essential oil, artemisia desertorum essential oil, artemisia selengensis essential oil, artemisia argyi essential oil, artemisia halodendron essential oil, artemisia alba essential oil, artemisia nigra essential oil, artemisia mollissima essential oil, artemisia alba essential oil, artemisia scoparia essential oil, artemisia argyi essential oil, artemisia apiacea essential oil, isoquercus angustifolia essential oil, artemisia sphaerocephala essential oil, artemisia rupestris essential oil, atractylodes macrocephala essential oil, atractylodes lancea essential oil, atractylodes macrocephala essential oil, galingale essential oil, galium small blumea essential oil, chrysanthemum flower essential oil, lysimachia foenum-graecum essential oil, melissa essential oil, primrose essential oil, vitex negundo essential oil, vitex essential oil, agastache rugosus essential oil, elsholly essential oil, elsholtzia essence oil, alpine essential oil, alpinia galangal, Turmeric essential oil, zedoary essential oil, ginger essential oil and calamus essential oil.
2. The use of claim 1, wherein the plant essential oil is one or a combination of two or more of the following essential oils:
folium et cacumen Murrayae essential oil, Japanese cedar wood essential oil, Atractylodes macrocephala essential oil, green sea Cuculus Rhododendri essential oil, cortex Cinnamomi Japonici essential oil, Curcuma rhizome essential oil, herba Artemisiae Annuae essential oil, herba Pteridis Davidii essential oil, herba Artemisiae Halodendri essential oil, folium Artemisiae Annuae essential oil, herba Artemisiae Ordosicae essential oil, rhizoma Atractylodis essential oil, folium Cudraniae essential oil, Curcumae rhizoma essential oil, folium Artemisiae Argyi essential oil, radix Curcumae essential oil, radix et rhizoma Wenyujin Concisa essential oil, herba Viticis Cannabifoliae essential oil, lignum Xanthii essential oil, herba Cudraniae Lanceolatae essential oil, radix et rhizoma Nardostachyos essential oil, herba Artemisiae Annuae essential oil, ramulus et folium Pterospermi Alternantherae essential oil, herba Asteris-idaeae essential oil, herba Ainsliaeae Yunnanensis essential oil, herba Artemisiae Halodendri essential oil, herba Artemisiae Halodendron salt, herba Artemisiae Annuae essential oil, chinese torreya essential oil, red fruit mountain pepper essential oil, triangle olive essential oil, stichopus japonicus essential oil, Dinghu Cinnamomum camphora essential oil and rhododendron anthopogonoides essential oil.
3. Use according to claim 1 or 2, characterized in that the sanitary article is a liquid or solid fumigant.
4. A hygienic product capable of inhibiting infection of a novel coronavirus is characterized by comprising 0.1-2.0% of plant essential oil in percentage by weight, wherein the plant essential oil is one or a combination of more than two of the following compounds:
chinese torreya essential oil, bamboo cypress essential oil, fir essential oil, cedar essential oil, oriental arborvitae essential oil, sabia przewalskii essential oil, purple jade disk essential oil, magnolia bark essential oil, cassia bark essential oil, Huangguggui essential oil, Dinghu cinnamomum longepaniculatum essential oil, geranium essential oil, red fruit mountain pepper essential oil, nanmu essential oil, cow hoof asarum essential oil, tremella aurantium essential oil, betel leaf essential oil, leaf-changing pepper essential oil, saururus chinensis essential oil, yellow cow wood essential oil, abelmoschus chinensis essential oil, nanmu essential oil, leaf-leaved Murraya essential oil, Murraya koenigii essential oil, Senecio scandens, trigonella essential oil, Michelia nobilis essential oil, Stichopus japonicus essential oil, ash leaf Chinese angelica essential oil, Xinjiang ligusticum essential oil, Ligusticum wallichii essential oil, Ligusticum chuanxiong essential oil, Benzonum tenuii essential oil, sandalwood essential oil, rhododendron essential oil, leaf essential oil, fragrant rhododendron leaf essential oil, fragrant, Green rhododendron essential oil, axillary rhododendron essential oil, spikenard essential oil, dahua spikenard essential oil, perlescent fragrant green essential oil, artemisia annua essential oil, artemisia anomala essential oil, artemisia desertorum essential oil, artemisia selengensis essential oil, artemisia argyi essential oil, artemisia halodendron essential oil, artemisia alba essential oil, artemisia nigra essential oil, artemisia mollissima essential oil, artemisia alba essential oil, artemisia scoparia essential oil, artemisia argyi essential oil, artemisia apiacea essential oil, isoquercus angustifolia essential oil, artemisia sphaerocephala essential oil, artemisia rupestris essential oil, atractylodes macrocephala essential oil, atractylodes lancea essential oil, atractylodes macrocephala essential oil, galingale essential oil, galium small blumea essential oil, chrysanthemum flower essential oil, lysimachia foenum-graecum essential oil, melissa essential oil, primrose essential oil, vitex negundo essential oil, vitex essential oil, agastache rugosus essential oil, elsholly essential oil, elsholtzia essence oil, alpine essential oil, alpinia galangal, Turmeric essential oil, zedoary essential oil, ginger essential oil and calamus essential oil.
5. The application of the perfume compound in preparing sanitary articles for inhibiting the infection power of the novel coronavirus, wherein the perfume compound is one or the combination of more than two of the following compounds:
arthrotriene, narcotine, curcumenol, Ranunculene, ar-turmerone, atractylone, beta-guaiene, guaiol, GUYUENE, 16-kauranol, arjunene, alantolactone, myrcene, alpha-bourbonene, Acorus, alpha-cedrene, steviol, eucalyptol, turmerone, curcuma aromatica, alpha-turmerone, beta-turmerone, nardol, alloxan, alpha-bisabolol, beta-bourbonene, chamazulene, artemisone, guaialene, gamma-GUYURENE, norlapachol, buxine, beta-cedrene, linalool, beta-thujol, beta-curarone, beta-curcumene, arol, mauritol, nardostachyone, pimazulene, shogaol, shogazeol, galangaol, valepotamune, zingiberene, caryophyllene, butrene, beta-pinol, beta-tussiol, carvacrol, mazinol, mazinone, beta-bavancone, azulene, kaempferol, ka, Germacrene, gamma-guaiene, alpha-guaiene, beta-cedrene, farrerone, thujene, beta-patchouliene, patchoulenone, angelicin, curcumene, beta-atlantic ketone, alpha-bisabolol oxide B, cedrol, beta-piperylene, alpha-curcumene, gamma-curcumene, zedoary dione, cyperone, Trans-farnesyl acetate, delta-guarene, isocalamendiol, trumpet alcohol, beta-muelene, hordeone, apiadiene, beta-apiene, (-) -delta-apiene, (+) -delta-apiene, apigenin, hanalol, (+) -delta-cadinene, alpha-cadinol, gamma-cadinen, costunolide, zedoarone, curcumene, Cumulene, Jacobsulene, beta-eucalyptol, (E) -beta-farnesene, gamma-cedrene, delta-ylaurene, glycazulene, alpha-apiene, sesquiphellandrene, caryophyllene, alpha-germacrone, 4-cadinen-7-ol, alpha-cadinene, beta-cadinene, tau-cadinene, capillone, copaene, copaenol, (-) -beta-piperylene, phellandrene, geranone, germacrone, myrtle, nootkene, phellandrene, oenantrol, beta-santalene, (E) -beta-santalol, senkyunol, gamma-apiene, phellandrene, vetiverol, rhodanesene, alpha-ylarene, calamenene, apienol, betulinol, bergamonol, bergamotol, Gamma-cadinene, delta-junenol, capillene block, alpha-cubylene, cubenol, xanthone isomer, dihydrofarnesol, eudesmol, humenol, alpha-elemene, (+) -beta-ylacene, gamma-ylacene, delta-patchoulene, (+) -alpha-santalene, torreya alcohol, elecampane ketene, aristolenone, dehydrocalamenene, carotol, piperitol, alpha-thujoanone, buconazole, (Z) -beta-farnesene, (-) -alpha-cedrene, humol, ligustilide, mugwort, gamma-elemene, methyl piperitol, estragole, ylarene, myristyl ether, neocnidide, hydroquinone dimethyl ether, gamma-patchoulene, alpha-santalene, santalum, santalol, alpha-santalone, alpha-santalol, alpha-linalool, humol, alpha-elenol, alpha-canarene, alpha-canarygenin, alpha-canaryne, beta-ylarene, alpha-ylasparteine, dihydrofarnesol, dihydrofarnes, Beta-santalol, (+) -beta-thujone, xanthone, alpha-ylang-ene, beta-asarone, ascaridole, bergapten, (-) -2-carene, betel phenol, bucindophenol, cumarone, germacrene, beta-guvacene, longifolene, alpha-patchoulene, (Z) -alpha-santalol, saussurea lactone, asarone, dehydroelsholtzia ketone, delta-elemene, gamma-elemene, elemenol, elsholtzia ketone, lupulin, methyl salicylate, patchoulol and ageratum.
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