CN112716489A

CN112716489A - Venous blood glucose detection device and detection method thereof

Info

Publication number: CN112716489A
Application number: CN202011508443.3A
Authority: CN
Inventors: 石鹤鹤; 李茜; 周翔
Original assignee: First Affiliated Hospital of Henan University of Science and Technology
Current assignee: First Affiliated Hospital of Henan University of Science and Technology
Priority date: 2020-12-18
Filing date: 2020-12-18
Publication date: 2021-04-30

Abstract

The invention discloses a venous blood sugar detection device which comprises a venous indwelling needle and a glucose sensor, wherein the venous indwelling needle is provided with two passages, namely a first passage for connecting an infusion apparatus and normal saline and a second passage for connecting a detection device main body. Has the advantages that: this application is kept somewhere the needle with the detection device main part and vein and is combined together the blood sugar that detects in the vein blood vessel, but intermittent type nature detects, also the sustainability detects, for prior art, can real-time supervision, it is more accurate to detect, and glucose sensor transmits the blood sugar value for the blood glucose meter, the real-time blood sugar value of blood glucose meter analysis, treat that numerical value sends for cell-phone or other communications facilities after the numerical value is stable, doctor, nurse or patient family members can know the blood sugar value, the doctor can use medicine according to the blood sugar value regulation.

Description

Venous blood glucose detection device and detection method thereof

Technical Field

The invention relates to the field of blood sugar detection, in particular to a venous blood sugar detection device and a detection method thereof.

Background

The control ability of a diabetic patient on blood sugar is reduced, the fluctuation of the blood sugar is more severe, the blood sugar fluctuation condition of some patients who pump insulin into the blood sugar or drip the blood sugar by veins is clinically known to adjust the dosage of insulin, and the continuous monitoring of the blood sugar is needed, and at present, the continuous monitoring of the blood sugar mainly comprises multi-time point finger blood sugar measurement and continuous dynamic glucose concentration monitoring in intercellular fluid. The operation of measuring the blood sugar by pointing at multiple time points is troublesome, patients feel more painful, and the detection times are limited; in the latter, a disposable glucose sensor is implanted subcutaneously into a patient and hundreds of blood glucose values can be recorded every day by the synergistic action of a data recorder, analysis software, and the like, but the blood glucose value in interstitial fluid has severe hysteresis and cannot be reflected in real time.

In the prior art, reference is also made to application number 2015204537608, namely an invasive pressure measurement arterial puncture needle capable of being used for continuous blood sugar monitoring, and blood sugar can be detected by connecting the arterial puncture needle to the artery while directly and dynamically measuring the arterial intravascular pressure through the invasive pressure measurement puncture needle in clinical operation. However, in clinical practice, arterial manometry is commonly used for patients with major blood loss during surgery, hemodynamically unstable diseases, severe hypertension, myocardial infarction, heart failure and the like, has few common indications with continuous blood glucose detection, and arterial puncture cannot be performed for measuring blood glucose, so that the clinical practice is not applicable, and compared with arterial puncture, the use of venous indwelling needles is quite common. In addition, clinically, the blood sugar is mainly measured by the venous blood sugar, the arterial blood sugar of a human body is slightly higher than the venous blood sugar, and the measurement of the arterial blood sugar is easy to cause patients and family members to mistakenly determine that the blood sugar is higher.

Disclosure of Invention

In order to solve the above problems, an object of the present invention is to provide a device that can be connected to a venous indwelling needle and can continuously detect a blood glucose level.

The invention realizes the purpose through the following technical scheme:

a venous blood sugar detection device comprises a venous indwelling needle and a glucose sensor, wherein the venous indwelling needle is provided with two passages which are a first passage for connecting an infusion apparatus and physiological saline and a second passage for connecting a detection device main body;

the detection device main body comprises a fixed joint, a movable seat, a glucose sensor, a connecting wire and an electrode, wherein the fixed joint is connected with the second channel, a guide hole is formed in the middle of the fixed joint, and a foldable protective sleeve is connected between the fixed joint and the movable seat; the electrode is arranged on the movable seat and penetrates through the middle part of the movable seat, so that one end of the electrode is positioned in the foldable protective sleeve, and the other end of the electrode is positioned on the outer side of the movable seat; one end of the electrode, which is positioned in the folding protective sleeve, is connected with a sealing plug, one end of the connecting wire is connected with the electrode, and the other end of the connecting wire penetrates through the guide hole to be connected with the glucose sensor.

Preferably, the venous indwelling needle comprises an extension tube connected with the first passage and the second passage, the other end of the extension tube is connected with a transparent needle seat, the needle seat is connected with a puncture needle, and the joint of the transparent needle seat and the puncture needle is an arc-shaped guide surface, so that the glucose sensor can enter the puncture needle along the arc-shaped guide surface.

Preferably, the fixed joint is in threaded connection with the second passage, and when the fixed joint is connected with the second passage, the glucose sensor is located in the second passage, and the initial position of the glucose sensor is arranged in a sensor protective sleeve, which is connected with the fixed joint.

Preferably, the movable seat is further provided with an exhaust pipe with two through ends, one end of the exhaust pipe is communicated with the foldable protective sleeve, and the other end of the exhaust pipe is communicated with the outside of the movable seat.

Preferably, the folding protective sleeve is a folding plastic hose;

the glucose sensor is oval and has a smooth surface; the glucose sensor has a minor axis length greater than the diameter of the guide hole.

Preferably, the sealing plug comprises a closing part with a diameter larger than that of the guide hole and a plunger part with a diameter equal to that of the guide hole, and the closing part is wrapped at the inner end part of the electrode; the sealing part is integrally processed and formed by adopting a rubber material.

Preferably, the fixed joint and the movable seat are externally provided with a shell, the inner wall of the shell is symmetrical about the folding protective sleeve, and two sliding grooves are formed in the inner wall of the shell along the length direction of the folding protective sleeve; be close to correspond the spout on the shell inside wall of fixed joint and install two motors, the output shaft of every motor all is connected with the lead screw, lead screw threaded connection has the slider, one side and the spout sliding connection of slider, opposite side and sliding seat fixed connection.

Preferably, the motor is electrically connected with a controller, and a timer and a warning lamp are arranged on the controller;

the glucose sensor is connected with the electrode through a connecting wire, the electrode is electrically connected with a glucometer, and the glucometer is connected with the mobile phone through a wireless signal.

A detection method using a venous blood sugar detection device comprises the following steps:

(1) sterilizing the venous indwelling needle and the detection device main body;

(2) connecting the first path of the venous indwelling needle with an infusion apparatus and physiological saline, exhausting air, and enabling the puncture needle to penetrate into a vein and be properly fixed, and clamping an extension tube of the venous indwelling needle; then, the second passage is screwed with the fixed joint, at the moment, the glucose sensor is positioned in the second passage, the guide hole is blocked in the initial state of the glucose sensor, then the exhaust pipe and the infusion apparatus are opened, the movable seat is pushed, the glucose sensor moves forwards for a certain distance, the normal saline is injected into the folding protective sleeve, air is exhausted, and the exhaust hole of the exhaust pipe is always communicated;

(3) when the blood sugar is detected, the motor is controlled by the controller to drive the screw rod to rotate, the sliding block drives the movable seat to move towards the fixed joint along the sliding groove, so that the glucose sensor is sent into a venous blood vessel through the extension tube and the puncture needle, the guide hole is blocked by the sealing plug, and then the infusion apparatus is closed;

(4) the glucose sensor converts a glucose content signal in blood into an electric signal and transmits the electric signal to the electrode through the connecting wire, the electrode amplifies a blood glucose signal transmitted by the glucose sensor and transmits the amplified blood glucose signal to an external blood glucose meter through a guide, the blood glucose meter receives the electric signal, analyzes and decodes the electric signal to generate a blood glucose value, and the blood glucose value is transmitted to a mobile phone or other communication equipment through a wireless signal;

(5) after the detection is finished, the operation controller controls the motor to drive the movable seat to move towards the direction far away from the fixed joint, the glucose sensor is pulled out of the venous blood vessel, and the venous indwelling needle is not influenced to be used for transfusion.

Preferably, in the step (3), when the blood glucose level is continuously detected, the blood glucose level is continuously detected by leaving the glucose sensor in the venous blood vessel, and 3 to 5 ml of the low-concentration heparin saline is instilled per hour by changing the physiological saline in the infusion set.

Has the advantages that: this application is kept somewhere the needle with the detection device main part and vein and is combined together the blood sugar that detects in the vein blood vessel, but intermittent type nature detects, also the sustainability detects, for prior art, can real-time supervision, it is more accurate to detect, and glucose sensor transmits the blood sugar value for the blood glucose meter, the real-time blood sugar value of blood glucose meter analysis, treat that numerical value sends for cell-phone or other communications facilities after the numerical value is stable, doctor, nurse or patient family members can know the blood sugar value, the doctor can use medicine according to the blood sugar value regulation.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a block diagram of the present invention;

FIG. 2 is a schematic diagram of the detection of the present invention;

fig. 3 is a control diagram of the controller and motor of the present invention.

The reference numerals are explained below:

1. puncturing needle; 2. a transparent needle base; 3. an extension tube; 4. a first path; 5. a second path; 6. a glucose sensor; 7. a sensor protective sleeve; 8. fixing the joint; 8a, a guide hole; 9. a connecting wire; 10. a foldable protective sleeve; 11. an electrode; 12. a sealing plug; 13. a movable seat; 14. an exhaust pipe; 15. a slider; 16. a lead screw; 17. a motor; 18. a controller; 18a, a timer; 18b, a warning light; 19. a blood glucose meter; 20. provided is a mobile phone.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.

Referring to fig. 1-3, the present invention provides a venous blood glucose detection device, comprising a venous indwelling needle and a glucose sensor 6, wherein the venous indwelling needle has two passages, namely a first passage 4 for connecting an infusion apparatus and physiological saline and a second passage 5 for connecting a detection device main body; the vein indwelling needle can be a vein puncture indwelling needle which is circulated in the market at present, and can also be a special vein indwelling needle. If the vein puncture indwelling needle in the prior art is used, only one passage is connected with the detection main body for use.

The detection device main part includes fixed joint 8, movable seat 13, glucose sensor 6, connecting wire 9 and electrode 11, fixed joint 8 is connected with second route 5, and optionally, fixed joint 8 passes through the screw thread and is connected with second route 5, and it is more convenient to connect. The middle of the fixed joint 8 is provided with a guide hole 8a, the connecting wire 9 penetrates through the guide hole 8a, the wire arranging function is achieved, the connecting wire 9 is possibly bent due to the fact that the glucose sensor 6 is pushed, when the glucose sensor is pulled back, the guide hole 8a can straighten the connecting wire 9, and the connecting wire 9 is made of elastic conductive materials. A folding protective sleeve 10 is connected between the fixed joint 8 and the movable seat 13; the electrode 11 is installed on the movable seat 13 and penetrates through the middle part of the movable seat 13, so that one end of the electrode 11 is located inside the foldable protective sleeve 10, and the other end is located outside the movable seat 13; one end of the electrode 11, which is positioned inside the folding protective sleeve 10, is connected with a sealing plug 12, one end of the connecting wire 9 is connected with the electrode 11, and the other end of the connecting wire passes through the guide hole 8a and is connected with the glucose sensor 6. Further, above-mentioned structure guiding hole 8a not only has the effect of reason line, but also has carminative effect, and when glucose sensor 6 stretched into venous blood vessel, guiding hole 8a intercommunication foldable protective sheath 10, with second passageway 5, can exhaust, when sealing plug 12 on the movable seat 13 stopped up guiding hole 8a one side, can also avoid liquid to flow this moment, guaranteed to measure accurately.

As a preferred embodiment of the present application, the venous indwelling needle comprises an extension tube 3 connected with a first passage 4 and a second passage 5, in order to facilitate observation and pushing of the glucose sensor 6, the other end of the extension tube 3 is connected with a transparent needle base 2, the needle base is connected with a puncture needle 1, and the joint of the transparent needle base 2 and the puncture needle 1 is an arc-shaped guide surface, so that the glucose sensor 6 can enter the puncture needle 1 along the arc-shaped guide surface.

Further, fixed joint 8 and second route 5 threaded connection, and when fixed joint 8 was connected with second route 5, glucose sensor 6 was located second route 5 to initial position locates in sensor protective sheath 7, sensor protective sheath 7 with fixed joint 8 is connected. Sensor protective sheath 7 is used for protecting glucose sensor 6, and simultaneously, initial state glucose sensor 6 is located second passageway 5 and can also shutoff guiding hole 8a, avoids the liquid outflow.

In order to facilitate air exhaust, an exhaust pipe 14 with two through ends is further arranged on the movable seat 13, one end of the exhaust pipe 14 is communicated with the foldable protective sleeve 10, and the other end of the exhaust pipe is communicated with the outside of the movable seat 13. Folding protective sheath is folding plastic hose, and folding protective sheath can be folded when propelling movement glucose sensor 6 to there is a small amount of liquid outflow when the exhaust, can flow in the folding protective sheath. In order to facilitate pushing and pulling back of the glucose sensor 6, the glucose sensor 6 is oval and has a smooth surface, which also reduces thrombus formation. The length of the short axis of the glucose sensor 6 is larger than the diameter of the guide hole 8a, so that the guide hole 8a can be blocked when the glucose sensor 6 is pulled back. Glucose comprises a semipermeable membrane, glucose oxidase and microelectrodes 11, and can convert the glucose content in blood into electric signals which are transmitted to the electrodes 11 through the connecting wires 9. Further, the sealing plug 12 includes a closing portion having a diameter larger than the guide hole 8a and a plunger portion having a diameter equal to the guide hole 8a, and the closing portion is wrapped around the inner end portion of the electrode 11; the sealing part is integrally formed by rubber materials, and the sealing part can further seal the guide hole 8a and protect the end part of the electrode 11. When the glucose sensor 6 is inserted into a venous blood vessel, the movable seat 13 is close to the fixed joint 8, at the moment, the plunger part of the sealing plug 12 is matched with the guide hole 8a, the detection precision is prevented from being influenced by liquid outflow, and the sealing part is abutted against the end face of the fixed joint 8, so that further sealing is realized. In the scheme, the electrode 11 extends to a longer length into the folding protective sleeve 10, so that the plunger can be matched with the guide hole 8a when the glucose sensor 6 extends into a vein.

As an important implementation manner of the present disclosure, in order to facilitate the slow and automatic pushing of the glucose sensor 6, the outer portions of the fixed joint 8 and the movable seat 13 are provided with a housing, and the inner wall of the housing is symmetrical about the folding protective sleeve and is provided with two sliding grooves along the length direction thereof; be close to correspond the spout and install two motors 17 on the shell inside wall of fixed joint 8, every motor 17's output shaft all is connected with lead screw 16, 16 threaded connection of lead screw has slider 15, one side and the spout sliding connection of slider 15, opposite side and sliding seat 13 fixed connection. The screw shaft 16 is a high-precision ball screw shaft 16 and can drive the movable base 13 to move slowly. The motor 17 is electrically connected with a controller 18, and a timer 18a and a warning lamp 18b are arranged on the controller 18; when the blood sugar is intermittently detected, the glucose sensor 6 is pushed into a vein to detect the real-time blood sugar, the timer 18a times, when the blood sugar detection is finished after a certain time, the warning lamp 18b flickers, and the controller 18 automatically controls the motor 17 to pull out the glucose sensor 6. The glucose sensor 6 is connected with an electrode 11 through a connecting wire 9, the electrode 11 is electrically connected with a blood glucose meter 19, and the blood glucose meter 19 is connected with a mobile phone 20 through a wireless signal. When clinically using insulin to correct blood sugar of a patient, hypoglycemia is caused by large dosage, the effect of lowering blood sugar by small dosage is not ideal, the repeated debugging is often needed, an alarm threshold value with too high or too low blood sugar can be set on the mobile phone 20 or other communication equipment, and an alarm sound is given out when the blood sugar value is too high or too low to trigger alarm, so that a doctor and a nurse are reminded to adjust the dosage of the insulin, and the condition that hypoglycemia cannot be found in time and the life of the patient is endangered is avoided.

(1) sterilizing the venous indwelling needle and the detection device main body; the indwelling needle and the glucose sensor 6 are kept sterile.

(2) Connecting a first passage 4 of the venous indwelling needle with an infusion apparatus and normal saline, exhausting air, and enabling the puncture needle 1 to penetrate into a vein and be fixed properly, and clamping an extension tube 3 of the venous indwelling needle; then, the second path 5 is screwed with the fixed joint 8, at this time, the glucose sensor 6 is positioned in the second path 5, the guide hole 8a is blocked by the glucose sensor 6 in the initial state, then the exhaust pipe 14 and the infusion apparatus are opened, the movable seat 13 is pushed, the glucose sensor 6 moves forwards for a certain distance, the physiological saline is injected into the folding protective sleeve 10, air is exhausted, the exhaust hole of the exhaust pipe 14 is always communicated, and the air can be exhausted all the time when the folding protective sleeve is compressed.

(3) When blood sugar is detected, the controller 18 controls the motor 17 to drive the screw rod 16 to rotate, the sliding block 15 drives the movable seat 13 to move towards the fixed joint 8 along the sliding groove, so that the glucose sensor 6 is sent into a venous blood vessel through the extension tube 3 and the puncture needle 1, the guide hole 8a is blocked by the sealing plug 12, then the infusion apparatus is closed, liquid is prevented from flowing out, and the detection precision is improved. During intermittent collection, the glucose sensor 6 is only required to measure stable values in a certain time, and then the motor 17 is controlled to pull back the glucose sensor 6. When the blood sugar value is continuously detected, the glucose sensor 6 is kept in the venous blood vessel, the blood sugar value is continuously detected, and the normal saline on the infusion apparatus is changed into the low-concentration heparin saline, and 3-5 ml of the low-concentration heparin saline is instilled every hour. When low-concentration heparin normal saline needs to be instilled, the control motor 17 drives the movable seat 13 to be far away from the fixed joint 8, and the glucose sensor 6 is pulled out.

(4) The glucose sensor 6 converts a glucose content signal in blood into an electric signal and transmits the electric signal to the electrode 11 through the connecting wire 9, the electrode 11 amplifies a blood glucose signal transmitted by the glucose sensor 6 and transmits the amplified blood glucose signal to an external blood glucose meter 19 through guidance, the blood glucose meter 19 receives the electric signal, a blood glucose value is generated after analysis and decoding, and the blood glucose value is transmitted to a mobile phone 20 or other communication equipment through a wireless signal; when insulin is clinically used for correcting the blood sugar of a patient, the large dosage of the insulin can cause hypoglycemia, and the effect of reducing the blood sugar is not ideal when the small dosage of the insulin is used. Often requiring repeated debugging. An alarm threshold value of too high or too low blood sugar can be set on the mobile phone 20 or other communication equipment, and when the blood sugar value is too high or too low, an alarm is triggered to give an alarm sound to remind doctors and nurses to adjust the insulin dosage. Avoid the hypoglycemia being not found in time and endangering the life of the patient.

(5) After the detection is finished, the operation controller 18 controls the motor 17 to drive the movable seat 13 to move towards the direction far away from the fixed joint 8, so that the glucose sensor 6 is pulled out from the venous blood vessel, and the venous indwelling needle is not influenced to be used for transfusion.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims

1. An intravenous blood glucose test device, comprising: the device comprises a venous indwelling needle and a glucose sensor, wherein the venous indwelling needle is provided with two passages, namely a first passage for connecting an infusion apparatus and physiological saline and a second passage for connecting a detection device main body;

2. The venous blood glucose test device of claim 1, wherein: the venous indwelling needle comprises an extension tube connected with the first passage and the second passage, the other end of the extension tube is connected with a transparent needle seat, the needle seat is connected with a puncture needle, and the joint of the transparent needle seat and the puncture needle is an arc-shaped guide surface, so that the glucose sensor can enter the puncture needle along the arc-shaped guide surface.

3. The venous blood glucose test device of claim 2, wherein: the fixed joint is in threaded connection with the second passage, and when the fixed joint is connected with the second passage, the glucose sensor is located in the second passage, and the initial position of the glucose sensor is arranged in the sensor protective sleeve which is connected with the fixed joint.

4. The venous blood glucose test device of claim 3, wherein: the movable seat is also provided with an exhaust pipe with two through ends, one end of the exhaust pipe is communicated with the folding protective sleeve, and the other end of the exhaust pipe is communicated with the outside of the movable seat.

5. The venous blood glucose test device of claim 4, wherein: the folding protective sleeve is a folding plastic hose;

6. The venous blood glucose test device of claim 5, wherein: the sealing plug comprises a sealing part with the diameter larger than that of the guide hole and a plunger part with the diameter equal to that of the guide hole, and the sealing part is wrapped at the inner end part of the electrode; the sealing part is integrally processed and formed by adopting a rubber material.

7. The venous blood glucose test device of claim 6, wherein: the outer parts of the fixed joint and the movable seat are provided with a shell, the inner wall of the shell is symmetrical about the folding protective sleeve, and two sliding grooves are formed in the inner wall of the shell along the length direction of the shell; be close to correspond the spout on the shell inside wall of fixed joint and install two motors, the output shaft of every motor all is connected with the lead screw, lead screw threaded connection has the slider, one side and the spout sliding connection of slider, opposite side and sliding seat fixed connection.

8. The venous blood glucose test device of claim 7, wherein: the motor is electrically connected with the controller, and the controller is provided with a timer and a warning lamp;

9. A test method using the venous blood sugar test device of claim 8, characterized in that: the method comprises the following steps:

(2) connecting the first path of the venous indwelling needle with an infusion apparatus and physiological saline, exhausting air, and enabling the puncture needle to penetrate into a vein and be properly fixed, and clamping an extension tube of the venous indwelling needle; then, the second passage is screwed with the fixed joint, at the moment, the glucose sensor is positioned in the second passage, the guide hole is blocked in the initial state of the glucose sensor, then the exhaust pipe and the infusion apparatus are opened, the movable seat is pushed, the glucose sensor moves forwards for a certain distance, the normal saline is injected into the folding protective sleeve, the air in the extension pipe is exhausted, and the exhaust hole of the exhaust pipe is always communicated;

10. The test method using the venous blood glucose test device according to claim 9, wherein: and (3) continuously detecting the blood sugar value, keeping the glucose sensor in the venous blood vessel all the time, continuously detecting the blood sugar value, and replacing the normal saline on the infusion apparatus with low-concentration heparin saline, and instilling 3-5 milliliters of the low-concentration heparin saline every hour.