CN112683983B - Sealed mass spectrometer - Google Patents
Sealed mass spectrometer Download PDFInfo
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- CN112683983B CN112683983B CN202011415197.7A CN202011415197A CN112683983B CN 112683983 B CN112683983 B CN 112683983B CN 202011415197 A CN202011415197 A CN 202011415197A CN 112683983 B CN112683983 B CN 112683983B
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- glove box
- mass spectrometer
- ion source
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- injection system
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E30/00—Energy generation of nuclear origin
- Y02E30/30—Nuclear fission reactors
Abstract
The invention discloses a sealed mass spectrometer which is used for carrying out radioactive sample analysis and comprises a mass spectrometer body and a glove box, wherein the mass spectrometer body comprises a sample injection system, an ion source and other components, and the sample injection system and the ion source are arranged in the glove box; the other parts are arranged outside the glove box. The invention not only can ensure the radiation safety of staff, but also is convenient for operation and maintenance.
Description
Technical Field
The invention belongs to the technical field of cores, and particularly relates to a sealed mass spectrometer which can be used for radioactive sample analysis.
Background
The nuclear facilities such as nuclear fuel post-treatment factories, chemical placing test facilities and the like generally need to carry out sample analysis, so that necessary parameters are provided for the processes such as technological processes, product indexes, environmental emission and the like. However, since these samples are radioactive, the pretreatment, analysis, etc. of the samples must be performed in a shielded cabinet with a sealing function to ensure the radiation safety of the staff.
The mass spectrometer is a common device for analyzing trace elements, ultra trace elements and isotopes, in particular to an inductively coupled plasma mass spectrometer (ICP-MS), and has the advantages of high precision, accurate measurement, high speed, wide linear range, high resolution and the like, and is an indispensable means for analyzing samples in nuclear facilities.
However, there is no sealed mass spectrometer specially aiming at the analysis of radioactive samples in the mass spectrometers currently sold on the market, in the past, when the mass spectrometer is adopted to analyze the radioactive samples, the whole mass spectrometer needs to be sealed in a customized glove box or a ventilation cabinet, so that not only is the operation and maintenance inconvenient, but also the problems of instability, easy corrosion, inconvenient maintenance, difficult solid waste treatment and the like exist due to the characteristics of continuous air intake and exhaust and open operation of the glove box, but the risk of radioactive escape exists when the sealed mass spectrometer is placed in the ventilation cabinet, and the radiation safety of personnel cannot be ensured.
Disclosure of Invention
The invention aims to solve the technical problems in the prior art, and provides the sealed mass spectrometer which can ensure the radiation safety of staff and is convenient to operate and maintain.
The technical scheme adopted for solving the technical problems of the invention is as follows:
the present invention provides a sealed mass spectrometer comprising:
a sealed mass spectrometer is used for carrying out radioactive sample analysis and comprises a mass spectrometer body and a glove box, wherein the mass spectrometer body comprises a sample injection system, an ion source and other components,
the sample injection system and the ion source are arranged in the glove box;
the other parts are arranged outside the glove box.
Preferably, the mass spectrometer body further comprises an interface structure, the sample injection system and the ion source are connected with the other components through the interface structure, the interface structure comprises a sample cone, a truncated cone and a connecting piece, and the sample cone and the truncated cone are arranged in the glove box and are opposite to the ion source; the connecting piece wraps the sample cone and the intercepting cone, and is in sealing connection with the glove box through a flange.
Preferably, in the sample injection system and the ion source, the ion source is high-frequency inductively coupled plasma.
Preferably, a sliding component is arranged in the glove box and used for driving the sample injection system and the ion source to slide in the glove box.
Preferably, the sliding assembly comprises a bracket and a sliding rail, the bracket is arranged below the sample injection system and the ion source, the sliding rail is arranged on the bracket along the horizontal direction, and the lower parts of the sample injection system and the ion source are arranged on the sliding rail in a penetrating manner.
Preferably, the other parts comprise an exhaust system and a vacuum system, the exhaust system comprises an exhaust pipe and an exhaust cover, one end of the exhaust pipe is communicated with an outlet end of a vacuum pump in the vacuum system, and the other end of the exhaust pipe extends into the glove box and is used for introducing gas generated by the vacuum system into the glove box;
the exhaust hood is arranged in the glove box and is near the sample injection system and the ion source and used for collecting waste gas generated when the ion source performs plasma treatment on the radioactive sample.
Preferably, the mass spectrometer further comprises a filter assembly, wherein the filter assembly comprises an exhaust filter, and the exhaust filter is arranged outside the glove box and is used for filtering and discharging exhaust gas inside the glove box to the outside of the glove box.
Preferably, the filter assembly further comprises an air inlet filter, wherein the air inlet filter is arranged outside the glove box and is used for filtering the external air and then introducing the external air into the glove box.
Preferably, the glove box comprises a box body, a plurality of gloves are arranged on the box body, the box body comprises a plurality of panels, wherein two oppositely arranged panels are made of transparent glass, and other panels are made of stainless steel.
Preferably, the glove box further comprises a pipe penetrating joint, an electric connector and a negative pressure monitoring device, wherein the pipe penetrating joint is used for conveying the reagent;
the electric connector is used for supplying power;
the negative pressure monitoring device is used for monitoring the pressure in the glove box;
and the glove box has a seal rating of at least 3.
According to the sealed mass spectrometer, the parts, such as the feeding system and the ion source, which need to be in direct contact with the radioactive sample are arranged in the sealed glove box, so that the parts are completely isolated from other parts which do not directly contact with the radioactive sample, compared with the existing mass spectrometer, the sealed mass spectrometer can realize the containment of radioactive substances and prevent the radioactive substances from leaking out, so that the radiation safety of workers is ensured, meanwhile, the operation and the maintenance are convenient, the analysis performance parameters are not changed, and the waste gas generated during the operation of the mass spectrometer can be introduced into the glove box for uniform filtration and emission, so that the pollution to the working environment can be prevented.
Drawings
Fig. 1 is a schematic diagram of a sealed mass spectrometer in an embodiment of the invention.
In the figure: 1-interface structure; 2-sample injection system and ion source; 3-exhaust hood; 4-glove box; 5-sliding rails; 6-an exhaust filter; 7-gloves; 8-other components; 9-exhaust pipe.
Detailed Description
The present invention will be described in further detail below with reference to the drawings and examples for better understanding of the technical scheme of the present invention to those skilled in the art. It should be noted that the embodiments of the present invention and the features in the embodiments may be combined with each other without conflicting with each other.
In the description of the present invention, it should be understood that the orientation or positional relationship indicated by the directional terms is based on the orientation or positional relationship shown in the drawings, and is merely for convenience of description and simplicity of description, and does not indicate or imply that the apparatus or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the invention.
Example 1
As shown in fig. 1, the present embodiment discloses a sealed mass spectrometer, including a mass spectrometer body, and a glove box 4, wherein: the mass spectrometer body comprises a sample injection system, an ion source 2 and other components 8, wherein the sample injection system and the ion source 2 are arranged in the glove box 4, and the other components 8 are arranged outside the glove box 4.
Compared with the existing mass spectrometer, the sealed mass spectrometer of the embodiment separates the parts, such as the feeding system and the ion source 2, which need to be in direct contact with the radioactive sample from other parts 8, such as parts not in direct contact with the radioactive sample, in the mass spectrometer body, so that the parts are respectively positioned inside and outside the glove box 4, and operations such as pretreatment, feeding and the like can be directly performed in the glove box 4 when the radioactive sample is analyzed, so that radioactive substances can be prevented from leaking out, the radiation safety of staff is ensured, the operation is convenient, the maintenance is convenient, and the analysis performance parameters of the mass spectrometer are not changed.
In some embodiments, the mass spectrometer body further comprises an interface structure 1, the interface structure 1 is arranged on the glove box 4 in a penetrating way, and the sample injection system and the ion source 2 are connected with other components 8 through the interface structure 1. Specifically, the other components 8 include ion lenses, mass analyzers, detectors, and the like, the interface structure 1 includes auxiliary components such as a sample cone, a skimmer cone, and a connector, and the glove box includes a box, wherein the sample cone and the skimmer cone (the same as or similar to the composition in the existing mass spectrometer) are disposed in the glove box 4, and the sample cone is opposite to an ion source so as to inhale ions generated when plasma treatment is performed at the ion source, and transmit the inhaled ions into cavities of the ion lenses, mass analyzers, detectors, and the like in the other components 8 in the mass spectrometer body; the connecting piece wraps the sample cone and the intercepting cone, and is connected with the box body of the glove box 4 in a sealing way through a flange, and the sample cone can avoid radioactive substances from leaking out.
In some embodiments, the ion source employs a high frequency inductively coupled plasma and the mass spectrometer body is an inductively coupled plasma mass spectrometer. More specifically, such inductively coupled plasma mass spectrometers may be inductively coupled plasma mass spectrometers (ICP-MS) with mass analyzers that are quaternary rods, high resolution mass spectrometers (HR-ICP-MS) with mass analyzers that are electromagnetically dual focused, multi-receive mass spectrometers (MC-ICP-MS), and other mass spectrometers that have similar related structures and are easily sealed.
In some embodiments, a sliding component is disposed in the glove box 4 and is used for driving the sample injection system and the ion source 2 to slide in the glove box 4, so that the feeding system and the ion source 2 are positioned at a position convenient for the operation and maintenance of a worker, and after the operation and maintenance are completed, the feeding system and the ion source 2 are slid to the original position.
In some embodiments, the slide assembly comprises a bracket, a slide rail 5 (or slide bar). The bracket is arranged below the sample injection system and the ion source 2, and the bracket has an adjusting function, for example, the bottom of the bracket can be provided with a horizontal adjusting screw to adjust the horizontal position of the bracket, and the bottom of the bracket can be also provided with a vertical adjusting screw to adjust the height of the bracket. The slide rail 5 is arranged on the bracket along the horizontal direction, and the lower parts of the feeding system and the ion source 2 are arranged on the slide rail 5 in a penetrating way.
In some embodiments, the sliding assembly further comprises a power member and a control switch (not shown), wherein the power member is connected with the feeding system and the ion source 2 to provide moving power, and the control switch is electrically connected with the power member to control the power member to output power. The control switch is preferably provided outside the glove box 4, for example, on a side plate of the glove box 4 casing.
In some embodiments, the power element may be an electric cylinder, that is, the electric power is used to drive the feeding system and the ion source 2 to move, and the electric cylinder is controlled to be electrified by a control switch. The power piece can also be an air cylinder, namely, the air cylinder is controlled to be charged by a control switch by adopting a pneumatic driving feeding system and the ion source 2 to move.
In some embodiments, the glove box 4 may be sized to: the length is 1200-2000mm, the width is 800-1200mm, and the height is 1400-2000mm, so as to ensure that the glove box 4 has enough internal space to meet the requirements of operation, maintenance and the like. In this embodiment, the glove box 4 is provided with a plurality of gloves 7 on the box, the box includes a plurality of panels, specifically, includes a plurality of side plates around, a top plate on the upper portion, and a bottom plate on the lower portion, the gloves 7 are preferably disposed on two opposite side plates in the box of the glove box 4, the number of the gloves 7 can be selected according to the requirement, for example, 6-10 gloves can be respectively disposed, and the two opposite side plates provided with the gloves 7 are preferably made of transparent glass, for example, transparent organic glass or toughened glass can be adopted. The feed cone in the interface structure 1 is arranged on any one of the other side plates in the box body, and the side plates, the top plate, the bottom plate and the other side plates are preferably made of stainless steel.
In some embodiments, the other components 8 of the present example sealed mass spectrometer comprise an exhaust system comprising an exhaust pipe 9 and an exhaust hood 3, and a vacuum system comprising a vacuum pump, wherein one end of the exhaust pipe 9 is in communication with the outlet end of the vacuum pump in the vacuum system, and the other end thereof protrudes into the glove box 4 for introducing exhaust gas generated by the vacuum system into the glove box 4; the exhaust hood 3 is disposed in the glove box 4 and near the sample injection system and the ion source, for example, may be disposed directly above the sample injection system and the ion source, and is used for collecting exhaust gas generated when the ion source performs plasma treatment on the radioactive sample. The waste gas generated by the vacuum system and the waste gas generated by plasma treatment are collected into the glove box 4 for unified treatment and discharge, so that the radioactive substances can be prevented from leaking, the pollution to the working environment is prevented, and the operation is convenient.
In some embodiments, the sealed mass spectrometer of the present embodiment further includes a filter assembly, the filter assembly includes an exhaust filter 6, the exhaust filter 6 is disposed outside the glove box 4, for example, may be disposed on a top plate of the glove box 4, one end of the exhaust pipe 9 extending into the glove box 4 is located at an inlet of the exhaust filter 6, and the exhaust filter 6 is preferably located above or at an outlet of the exhaust hood 3, so as to filter and exhaust the exhaust gas inside the glove box 4 (including the exhaust gas exhausted from the vacuum system and the exhaust gas generated at the ion source) to the outside of the glove box 4.
In some embodiments, the filter assembly further includes an air intake filter disposed outside the glove box 4, for example, on a top plate of the glove box 4, for filtering and introducing the external air into the glove box 4, so as to help regulate and maintain the pressure in the glove box 4.
In some embodiments, a negative pressure monitoring device (not shown in the figure) is further disposed on the glove box 4, and the negative pressure detecting device is used for detecting the pressure in the glove box 4, so as to ensure that the pressure in the glove box 4 is maintained at a required negative pressure, so as to prevent the radiation from leaking out. In this embodiment, the negative pressure value in the glove box 4 is preferably-200 to-300 Pa.
In some embodiments, the glove box 4 may further be provided with auxiliary components such as a pipe penetrating joint, an electric connector, and a lamp (not shown in the figure), where the pipe penetrating joint is used for conveying a reagent, the electric connector is used for supplying power, and the lamp is used for lighting.
In some embodiments, the sealed mass spectrometer of the present embodiment may further comprise a support, the mass spectrometer body and the glove box 4 are both disposed on the support, and the height of the support is preferably 500-800mm for the convenience of staff.
In some embodiments, the glove box 4 should have a seal rating of at least 3 to ensure a sealing effect.
In summary, in the sealed mass spectrometer of this embodiment, the parts that need to be in direct contact with the radioactive sample, such as the feeding system and the ion source, are disposed in the sealed glove box, so that the parts that do not directly contact with the radioactive sample, such as the ion lens, the mass analyzer, the detector, and the vacuum system in the mass spectrometer body, are completely isolated.
It is to be understood that the above embodiments are merely illustrative of the application of the principles of the present invention, but not in limitation thereof. Various modifications and improvements may be made by those skilled in the art without departing from the spirit and substance of the invention, and are also considered to be within the scope of the invention.
Claims (6)
1. A sealed mass spectrometer for radioactive sample analysis comprises a mass spectrometer body, and is characterized by further comprising a glove box (4), wherein the mass spectrometer body comprises a sample injection system, an ion source (2), other components (8) and a filtering assembly,
the sample injection system and the ion source are arranged in the glove box;
the other parts are arranged outside the glove box and comprise an exhaust system and a vacuum system, the exhaust system comprises an exhaust pipe (9) and an exhaust cover (3),
one end of the exhaust pipe is communicated with the outlet end of a vacuum pump in the vacuum system, the other end of the exhaust pipe extends into the glove box and is used for introducing exhaust gas generated by the vacuum system into the glove box, the exhaust hood is arranged in the glove box and is positioned above the sample injection system and the ion source and is used for collecting exhaust gas generated when the ion source performs plasma treatment on a radioactive sample, the filter assembly comprises an exhaust filter (6), the exhaust filter is arranged outside the glove box and is used for filtering and discharging the exhaust gas in the glove box to the outside of the glove box, the exhaust filter is positioned above or at the outlet of the exhaust hood, and one end of the exhaust pipe extending into the glove box is positioned at the inlet of the exhaust filter;
a sliding component is arranged in the glove box and is used for driving the sample injection system and the ion source to slide in the glove box,
the sliding assembly comprises a bracket and a sliding rail (5), the bracket is arranged below the sample injection system and the ion source, the sliding rail is arranged on the bracket along the horizontal direction, the bottom of the bracket is provided with a horizontal adjusting screw for adjusting the horizontal position of the bracket and a vertical adjusting screw for adjusting the height of the bracket, and the lower parts of the sample injection system and the ion source are arranged on the sliding rail in a sliding manner.
2. The sealed mass spectrometer according to claim 1, wherein the mass spectrometer body further comprises an interface structure (1), the sample injection system and the ion source are connected with the other components through the interface structure,
the interface structure comprises a sample cone, a truncated cone and a connecting piece,
the sample cone and the interception cone are arranged in the glove box and are opposite to the ion source;
the connecting piece wraps the sample cone and the intercepting cone, and is in sealing connection with the glove box through a flange.
3. The sealed mass spectrometer of claim 1, wherein the ion source is a high frequency inductively coupled plasma in the sample injection system and ion source.
4. The sealed mass spectrometer of claim 1, wherein the filter assembly further comprises an air intake filter,
the air inlet filter is arranged outside the glove box and is used for filtering external air and then introducing the external air into the glove box.
5. The sealed mass spectrometer according to any of the claims 1-4, wherein the glove box comprises a box with a plurality of gloves (7) thereon,
the box body comprises a plurality of panels, wherein two panels which are oppositely arranged are made of transparent glass, and other panels are made of stainless steel.
6. The sealed mass spectrometer of claim 5, wherein the glove box further comprises a feedthrough, an electrical connector, and a negative pressure monitoring device,
the pipe penetrating joint is used for conveying a reagent;
the electric connector is used for supplying power;
the negative pressure monitoring device is used for monitoring the pressure in the glove box;
and the glove box has a seal rating of at least 3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011415197.7A CN112683983B (en) | 2020-12-03 | 2020-12-03 | Sealed mass spectrometer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011415197.7A CN112683983B (en) | 2020-12-03 | 2020-12-03 | Sealed mass spectrometer |
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| CN112683983A CN112683983A (en) | 2021-04-20 |
| CN112683983B true CN112683983B (en) | 2023-06-30 |
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| CN202011415197.7A Active CN112683983B (en) | 2020-12-03 | 2020-12-03 | Sealed mass spectrometer |
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| CN113281444A (en) * | 2021-06-21 | 2021-08-20 | 江苏赫尔斯检测技术有限公司 | Method for determining heavy metals in cosmetics by inductively coupled plasma mass spectrometer |
| CN114967541B (en) * | 2022-05-10 | 2022-11-29 | 中国核电工程有限公司 | Electric control system of thermal ionization mass spectrometer |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5730765A (en) * | 1996-04-10 | 1998-03-24 | The United States Of America As Represented By The Secretary Of The Army | Super toxic analytical glove box system |
| CN201549467U (en) * | 2009-11-10 | 2010-08-11 | 北京有色金属研究总院 | Interface device utilizing glow-discharge ion source mass spectrometry |
| CN104807876A (en) * | 2015-05-27 | 2015-07-29 | 中国工程物理研究院材料研究所 | Electrospray ionization mass spectrometry combined system used for radioactive substances and using method for electrospray ionization mass spectrometry combined system |
| CN107576614A (en) * | 2017-07-24 | 2018-01-12 | 王立辉 | Sampling system separates with radio-frequency signal generator and closed system |
| CN108562572A (en) * | 2018-06-29 | 2018-09-21 | 中国原子能科学研究院 | A kind of inductively-coupled plasma spectrometer seal operation case |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4636800B2 (en) * | 2002-03-08 | 2011-02-23 | ヴァリアン オーストラリア ピーティーワイ．エルティーディー． | Plasma mass spectrometer |
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2020
- 2020-12-03 CN CN202011415197.7A patent/CN112683983B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5730765A (en) * | 1996-04-10 | 1998-03-24 | The United States Of America As Represented By The Secretary Of The Army | Super toxic analytical glove box system |
| CN201549467U (en) * | 2009-11-10 | 2010-08-11 | 北京有色金属研究总院 | Interface device utilizing glow-discharge ion source mass spectrometry |
| CN104807876A (en) * | 2015-05-27 | 2015-07-29 | 中国工程物理研究院材料研究所 | Electrospray ionization mass spectrometry combined system used for radioactive substances and using method for electrospray ionization mass spectrometry combined system |
| CN107576614A (en) * | 2017-07-24 | 2018-01-12 | 王立辉 | Sampling system separates with radio-frequency signal generator and closed system |
| CN108562572A (en) * | 2018-06-29 | 2018-09-21 | 中国原子能科学研究院 | A kind of inductively-coupled plasma spectrometer seal operation case |
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