CN112674835A - Thrombus taking device - Google Patents
Thrombus taking device Download PDFInfo
- Publication number
- CN112674835A CN112674835A CN202011438406.XA CN202011438406A CN112674835A CN 112674835 A CN112674835 A CN 112674835A CN 202011438406 A CN202011438406 A CN 202011438406A CN 112674835 A CN112674835 A CN 112674835A
- Authority
- CN
- China
- Prior art keywords
- core wire
- wire section
- hypotube
- moving block
- thrombus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention discloses a thrombus taking device, and belongs to the technical field of machinery. The thrombus taking device comprises a handle, a pushing device and a thrombus taking support, wherein the handle comprises an adjuster, a core rod, a track and a moving block capable of sliding along the core rod on the track along with the rotation of the adjuster, the pushing device comprises a guide wire and a hypotube, the guide wire sequentially comprises a first isodiametric core wire section, a reducing core wire section and a second isodiametric core wire section from a near end to a far end, the near end of the first isodiametric core wire section is fixed on the core rod, the far end of the first isodiametric core wire section extends out of a shell from a handle head and extends to the thrombus taking support, the reducing core wire section penetrates through the thrombus taking support, the hypotube is wrapped outside the first isodiametric core wire section, so that the guide wire can move in the hypotube, the near end of the hypotube is fixed on the moving block, the far end of the hypotube extends out of the shell from the handle head and extends to the thrombus taking support, the near end of the thrombus taking support is fixed on, the size of the embolus making bracket is controlled.
Description
Technical Field
The invention relates to a thrombus taking device, and belongs to the technical field of machinery.
Background
Acute stroke is the third leading cause of death today and is the leading cause of disability in adults, with ischemic stroke accounting for about 85% of acute stroke. Ischemic stroke is mainly caused by embolization of larger vessels (diameter >2mm), and the lethality of embolization of larger vessels is 53% -92%. It can be seen that ischemic stroke is a disease with high morbidity, high disability rate and high mortality.
At present, the methods which are proved to be effective in treating ischemic stroke by medicine mainly comprise medicinal thrombolysis and mechanical thrombus removal. The method mainly comprises the steps of placing the medicine at a pathological position by using a catheter and then releasing the medicine to form a high medicine concentration locally, wherein the rt-PA activates plasminogen to become plasmin-dissolving blood clots through plasminogen arginine-valine so as to achieve the purpose of thrombolysis. However, the actual thrombolysis rate of this method is low. The drug thrombolysis treatment rate of developed countries is only 4.1-6.3%, and the thrombolysis treatment rate of the developed countries is lower. Therefore, drug thrombolysis has not been able to fully meet clinical needs.
The mechanical thrombus removal is mainly realized by puncturing the femoral artery, passing a thrombus removal device through the blood vessel to the position of the blood vessel occlusion, then passing the blood vessel occlusion, and removing the thrombus through the thrombus removal device or a thrombus removal catheter to recover the blood flow of the blood vessel so as to achieve the purpose of thrombus removal. Compared with the medicine thrombolysis, the mechanical thrombolysis obviously improves the blood vessel recanalization rate.
Mechanical thrombectomy devices can be divided into proximal thrombectomy devices (located proximal to the thrombus) and distal thrombectomy devices (located distal to the thrombus), depending on the placement location. The proximal thrombus taking device mainly comprises a thrombus taking suction catheter, and the distal thrombus taking device mainly comprises a capturing thrombus taking device and a rotary cutting thrombus taking device. Currently, the commercially available distal embolectomy devices mainly include Merci embolectomy devices (Concentric, Mountain view. calif.), Catchdevice (Bah Extrusion, montmorency. france), InTime and attacter devices (Boston Scientific, nature, Mass.), and Phenox embolectomy devices (Phenox, bochmum, germann). However, the existing distal embolectomy devices are easy to damage the inner wall of the blood vessel, and the risk of reperfusion injury of the blood vessel during mechanical embolectomy is greatly increased. In addition, the existing distal thrombus removal device has many defects, for example, after the thrombus removal stent of the existing distal thrombus removal device expands at a lesion position, the expanded size of the thrombus removal stent cannot be controlled according to the size of a lesion blood vessel; the existing distal thrombus taking device can not judge the state of the thrombus taking bracket in the body; the distal end of a thrombus taking bracket of the existing distal end thrombus taking device is in an open state, so that thrombus is easy to escape and fall off; the thrombectomy stents of the prior distal thrombectomy devices require catheter assistance to reach the lesion site.
Therefore, it is urgently needed to design a far-end thrombus taking device which is not easy to damage the inner wall of a blood vessel, has controllable expansion size of the thrombus taking stent, can be developed, can effectively prevent thrombus from escaping, and can reach a diseased region without the assistance of a catheter so as to overcome the defects of the existing far-end thrombus taking device.
Disclosure of Invention
[ problem ] to
The invention aims to solve the technical problem of providing a far-end thrombus taking device which is not easy to damage the inner wall of a blood vessel, has controllable expansion size of a thrombus taking bracket, can display images, can effectively prevent thrombus from escaping, and can reach a diseased region without the assistance of a catheter.
[ solution ]
In order to solve the technical problem, the invention provides a thrombus removal device, which comprises a handle 1, a pushing device 2 and a thrombus removal support 3;
the handle 1 comprises a shell 4, a moving block 5, a core rod 6 and an adjuster 7; the housing 4 comprises a crown 8 and a tang 9; the crown 8 and the tail 9 are connected through a plurality of tracks 10; the moving block 5 is positioned between the crown 8 and the shank tail 9, and a plurality of first bulges 11 and a plurality of second bulges 12 are arranged on the moving block 5; the first protrusion 11 is engaged with the track 10, so that the moving block 5 can slide on the track 10; the second bulge 12 is provided with threads; one end of the core rod 6 is inserted into the crown 8, and the other end of the core rod is inserted into the moving block 5, so that the moving block 5 can slide on the track 10 along the core rod 6; the adjuster 7 is in a cylindrical shape with openings at two ends, the adjuster 7 is wrapped on the outer sides of the track 10 and the moving block 5, and the inner wall of the adjuster 7 is provided with threads matched with the second protrusions 12, so that the moving block 5 can slide on the track 10 along the core rod 6 along with the rotation of the adjuster 7;
the pushing device 2 comprises a guide wire 13 and a hypotube 14; the guide wire 13 comprises a first equal-diameter core wire section 15, a reducing core wire section 16, a second equal-diameter core wire section 17 and a tip 18 from the proximal end to the distal end in sequence; a plurality of pairs of cut depressions 19 are uniformly distributed on the diameter-variable core wire section 16 along the axial direction, two depressions 19 of the same pair are symmetrically arranged about the axis of the diameter-variable core wire section 16, and two adjacent pairs of depressions 19 are arranged in a staggered manner; the proximal end of the first isometric core wire section 15 is fixed on the core rod 6, and the distal end of the first isometric core wire section extends out of the shell 4 from the handle head 8 and extends to the embolectomy support 3; the reducing core wire section 16 penetrates through the bolt taking support 3; the hypotube 14 is wrapped outside the first isodiametric core wire segment 15, so that the guide wire 13 can move in the hypotube 14, the proximal end of the hypotube 14 is fixed on the moving block 5, and the distal end of the hypotube 14 extends out of the shell 4 from the handle 8 and extends to the embolectomy stent 3;
the proximal end of the thrombus taking support 3 is fixed on the distal end of the hypotube 14, and the distal end is fixed on the reducing core wire section 16, so that the thrombus taking support 3 can expand and contract along with the sliding of the moving block 5.
In one embodiment of the invention, the thrombectomy stent 3 is secured at a proximal end to the distal end of the hypotube 14 and at a distal end to the interface of the reducer core wire segment 16 and the second isodiametric core wire segment 17.
In one embodiment of the present invention, a first developing ring 20 and a second developing ring 21 are provided on the guide wire 13; the first developing ring 20 is positioned at the joint of the far end of the bolt taking bracket 3 and the reducing core wire section 16; the second developing ring 21 is positioned at the joint of the proximal end of the embolectomy stent 3 and the distal end of the hypotube 14.
In one embodiment of the present invention, the first and second developing rings 20 and 21 are platinum-iridium alloy material; the first developing ring 20 is welded or optically fixed on the bolt taking bracket 3 and the reducing core wire section 16 by using an optical fixing glue; the second developing ring 21 is welded or optically fixed on the bolt taking bracket 3 by using an optical cement glue.
In one embodiment of the present invention, the maximum outer diameter of the first and second developing rings 20 and 21 is not more than 0.64 mm.
In one embodiment of the invention, the embolectomy device comprises a graduated ring 22; the scale ring 22 is wrapped around the track 10 and the moving block 5, and the scale ring 22 is located between the shank tail 9 and the adjuster 7.
In one embodiment of the present invention, the number of the rails 10 is two, and the two rails 10 are disposed at 180 ° opposite to each other.
In one embodiment of the present invention, the thrombectomy stent 3 has a mesh structure.
In one embodiment of the invention, the thrombectomy stent 3 is woven from 48 pieces of nickel titanium shape memory alloy round wire with a wire diameter of 0.04mm, and the weaving density is 45PPI at the head end and 57PPI at the middle section.
In one embodiment of the invention, the thrombectomy stent 3 is woven from 48 pieces of nitinol round wire with a wire diameter of 0.04mm in 2 knots.
In one embodiment of the invention, the thrombectomy stent 3 is formed by weaving 48 pieces of nickel-titanium shape memory alloy round wires with the wire diameter of 0.04mm in 2 pieces, and 2-3 pieces of the 48 pieces of nickel-titanium shape memory alloy wires are replaced by platinum-tungsten wires.
In one embodiment of the invention, the platinum tungsten wire is a developable platinum tungsten wire.
In one embodiment of the invention, the platinum tungsten wire is PtW 8% platinum tungsten wire.
In one embodiment of the invention, the thrombectomy stent 3 has a length of 40mm in the fully contracted state and 30mm in the fully expanded state.
In one embodiment of the invention, the radial support force of the thrombectomy stent 3 remains constant during expansion.
In one embodiment of the invention, the thrombectomy stent 3 has heparin coatings on both the inner and outer surfaces.
In one embodiment of the present invention, the hypotube 14 is a four-way hypotube formed by laser cutting a tube of high elastic shape memory alloy.
In one embodiment of the present invention, the high elasticity shape memory alloy tube is a high elasticity nickel titanium shape memory alloy tube.
In one embodiment of the present invention, the hypotube 14 has an outer diameter of 0.38mm, an inner diameter of 0.15mm, and a length of 200 cm.
In one embodiment of the present invention, the cut length of the hypotube 14 is 45 cm.
In one embodiment of the invention, the recesses 19 are cut in a four-way cut with a cutting taper of 0.15 °, the length of the individual recesses 19 being 0.1mm and the distance between each recess 19 being 0.05 mm.
In one embodiment of the invention, two adjacent pairs of recesses 19 are staggered by 180 °.
In one embodiment of the invention, the recess 19 is annular in cross-section.
In one embodiment of the invention, the depressions 19 are distributed starting at a position on the reducing core wire section 16 which is 0.5mm from the connection of the first equal diameter core wire section 15 and the reducing core wire section 16.
In one embodiment of the present invention, the tip 18 includes a straight section 24 and a cut-off tapered section 25 from the distal end to the proximal end, and the diameter of the tapered section 25 gradually decreases from the proximal end to the distal end.
In one embodiment of the present invention, the cutting taper section 25 has a cutting taper of 0.6 ° and a length of 4 mm.
In one embodiment of the present invention, the straight section 24 has an outer diameter of 0.07mm and a length of 8 mm.
In one embodiment of the present invention, the first isodiametric core filament segment 15 has a hydrophobic coating on its surface.
In one embodiment of the present invention, the thickness of the hydrophobic coating on the surface of the first isodiametric core wire section 15 is 0.004-0.010 mm.
In one embodiment of the present invention, the hydrophobic coating on the surface of the first isodiametric core filament segment 15 is a green PTFE hydrophobic coating.
In one embodiment of the present invention, the material of the first isodiametric core wire segment 15 is SS304 stainless steel.
In one embodiment of the present invention, the first isodiametric core wire segment 15 has an outer diameter of 0.14mm and a length of 200 mm.
In one embodiment of the present invention, the reducing core wire segment 16 has a hydrophilic coating on its surface.
In one embodiment of the present invention, the hydrophilic coating on the surface of the reducing core wire segment 16 is a PVP-povidone hydrophilic coating.
In one embodiment of the invention, the thickness of the hydrophilic coating on the surface of the reducing core wire section 16 is 0.004-0.010 mm.
In one embodiment of the present invention, the variable diameter core wire section 16 is a nickel titanium alloy.
In one embodiment of the invention, the reducing core wire section 16 has an outer diameter of 0.14mm and a length of 40 mm.
In one embodiment of the present invention, the first constant diameter core wire section 15 and the variable diameter core wire section 16 are connected with a firmness of not less than 10N.
In one embodiment of the invention, the second isodiametric core filament segment 17 has a hydrophilic coating on its surface.
In one embodiment of the invention, the thickness of the hydrophilic coating on the surface of the second equal-diameter core wire section 17 is 0.004-0.010 mm.
In one embodiment of the present invention, the hydrophilic coating on the surface of the second equal-diameter core wire section 17 is a PVP polyvinyl pyrrolidone hydrophilic coating.
In one embodiment of the invention, the material of the second isodiametric core wire section 17 is nitinol.
In one embodiment of the invention, the second isodiametric core wire segment 17 has an outer diameter of 0.14mm and a length of 10 mm.
In one embodiment of the invention, the tip 18 is a nickel titanium alloy.
In one embodiment of the present invention, the reducing core wire section 16, the second equal diameter core wire section 17 and the tip 18 are cut from the same nitinol strip.
In one embodiment of the invention, the tip 18 is provided with a spring ring 23.
In one embodiment of the present invention, the two ends of the spring ring 23 are welded or cemented to the tip 18, and the welded or cemented point is smooth and burr-free, and the maximum outer diameter of the welded or cemented point does not exceed the outer diameter of the spring ring 23.
In one embodiment of the present invention, the proximal bottom of the spring ring 23 is conical, and the distal top is rounded.
In one embodiment of the present invention, the spring ring 23 has a hydrophilic coating on its surface.
In one embodiment of the present invention, the thickness of the hydrophilic coating on the surface of the spring ring 23 is 0.004-0.010 mm.
In one embodiment of the present invention, the hydrophilic coating on the surface of the spring ring 23 is a PVP-polyvinylpyrrolidone hydrophilic coating.
In one embodiment of the present invention, the spring ring 23 is an under-beam developable platinum-nickel alloy material.
In one embodiment of the invention, the spring ring 23 has a length of 12mm, an outer diameter of 0.25mm and an inner diameter of 0.16 mm.
In one embodiment of the present invention, the moving distance of the moving block 5 is 0 to 10 mm.
[ advantageous effects ]
(1) The invention provides a thrombus taking device which comprises a handle, a pushing device and a thrombus taking support, wherein the pushing device comprises a guide wire and a hypotube wrapped outside the guide wire, the far end of the guide wire is a tip, and a spring ring is sleeved on the tip, so that the part of the thrombus taking device, which is in contact with the inner wall of a blood vessel, has excellent flexibility and is not easy to damage the inner wall of the blood vessel; the hypotube is a four-way hypotube made of high-elasticity shape memory alloy, can smoothly pass through a tortuous blood vessel, and enables the thrombus taking device to reach a distal thrombus taking device of a lesion part without the assistance of a catheter.
(2) The invention provides a thrombus taking device which comprises a handle, a pushing device and a thrombus taking support, wherein the handle comprises an adjuster, a core rod, a track and a moving block capable of sliding along the core rod on the track along the rotation of the adjuster, the pushing device comprises a guide wire and a hypotube, the guide wire sequentially comprises a first isodiametric core wire section, a reducing core wire section, a second isodiametric core wire section and a tip end from a near end to a far end, the near end of the first isodiametric core wire section is fixed on the core rod, the far end of the first isodiametric core wire section extends out of a shell from a handle head and extends to the thrombus taking support, the reducing core wire section penetrates through the thrombus taking support, the hypotube is wrapped outside the first isodiametric core wire section, so that the guide wire can move in the hypotube, the near end of the hypotube is fixed on the moving block, the far end of the hypotube extends out of the shell from the handle head and extends, The far end is fixed on the reducing core wire section of the guide wire, so that the thrombus taking device can control the size of the thrombus taking support through rotating the adjuster of the handle, thereby fitting the size of the inner wall of the blood vessel and regulating and controlling the radial supporting force of the thrombus taking support on the inner wall of the blood vessel.
(3) The invention provides a thrombus taking device which comprises a handle, a pushing device and a thrombus taking support, wherein the thrombus taking support is formed by weaving 45-46 ingots of nickel-titanium shape memory alloy round wires with the wire diameter of 0.04mm and 2-3 developable platinum-tungsten round wires, and a first developing ring and a second developing ring are arranged on a guide wire of the pushing device, so that the thrombus taking device is integrally developed, and the state and the position of the thrombus taking support in a blood vessel can be judged.
(4) The invention provides a thrombus taking device which comprises a handle, a pushing device and a thrombus taking support, wherein the thrombus taking support is a net-shaped structure with a 57PPI middle section, the 45PPI head end is formed by weaving 45-46 ingots of nickel-titanium shape memory alloy round wires with the wire diameter of 0.04mm and 2-3 developable platinum-tungsten round wires, so that the thrombus taking device is not easy to cut thrombus and has small damage to blood vessels, and the two ends of the thrombus taking support are in a closed state, so that the thrombus taking device can be effectively prevented from escaping and falling off in an operation.
(5) The invention provides a thrombus taking device, wherein a guide wire of the thrombus taking device sequentially comprises a first equal-diameter core wire section, a reducing core wire section, a second equal-diameter core wire section and a tip end from a near end to a far end, a plurality of pairs of depressions formed by cutting are uniformly distributed on the reducing core wire section along the axial direction, two depressions of the same pair are symmetrically arranged relative to the axis of the reducing core wire section, two adjacent pairs of depressions are arranged in a staggered mode, and the arrangement of the core wire sections enables the whole guide wire of the thrombus taking device to have stable supporting force and better torque transmission capacity (up to 1:1) at the same time.
(6) The invention provides a thrombus taking device, wherein two surfaces of a thrombus taking support of the thrombus taking device are respectively provided with a heparin coating, and the arrangement of the heparin coatings can effectively prevent blood from forming blood clots on the surface of the thrombus taking support to block the thrombus taking support, so that the thrombus taking support of the thrombus taking device is not easy to block in the thrombus taking process.
(7) The invention provides a thrombus taking device, wherein hydrophilic coatings are arranged on the surfaces of a reducing core wire section, a second equal-diameter core wire section and a spring ring of a guide wire of the thrombus taking device, and the arrangement of the hydrophilic coatings can reduce the friction force of the guide wire of the thrombus taking device on a blood vessel when the guide wire passes through the blood vessel, so that the guide wire of the thrombus taking device is not easy to damage the blood vessel.
(8) The invention provides a thrombus taking device, wherein a hydrophobic coating is arranged on the surface of a first isodiametric core wire section of a guide wire of the thrombus taking device, and the hydrophobic coating can effectively reduce the friction force between the first isodiametric core wire section and the inner wall of an outer pipe of a hypotube, so that a thrombus taking support of the thrombus taking device is smoother in the processes of contraction and expansion.
Drawings
FIG. 1: the invention discloses a whole structure schematic diagram of one embodiment of a thrombus removal device.
FIG. 2: the invention discloses a partial structure schematic diagram of one embodiment of a thrombus removal device.
FIG. 3: the invention discloses a cross-sectional structure schematic diagram of one embodiment of a thrombus removal device.
FIG. 4: the invention discloses a schematic overall structure diagram of an embodiment of a moving block of a bolt taking device.
Fig. 5 is a schematic view of the overall structure of one embodiment of the guidewire of the present invention.
Fig. 6 is a schematic diagram of the overall structure of one embodiment of a constant diameter core wire segment of a guidewire of the present invention.
Fig. 7 is a partial structural schematic view of one embodiment of a constant diameter core wire segment of a guidewire of the present invention.
Fig. 8 is an enlarged schematic view of a portion a in fig. 7.
In fig. 1-8, a handle 1, a pushing device 2, a thrombus removal support 3, a housing 4, a moving block 5, a core rod 6, an adjuster 7, a handle head 8, a handle tail 9, a track 10, a first protrusion 11, a second protrusion 12, a guide wire 13, a hypotube 14, a first isodiametric core wire segment 15, a reducing core wire segment 16, a second isodiametric core wire segment 17, a tip 18, a recess 19, a first developing ring 20, a second developing ring 21, a scale ring 22, a spring ring 23, a straight segment 24, and a sharpening segment 25.
Detailed Description
The invention will be further elucidated with reference to the embodiments and the drawings.
Example 1: guide wire
1-8, the invention provides a thrombus removal device, which comprises a handle 1, a pushing device 2 and a thrombus removal support 3;
the handle 1 comprises a shell 4, a moving block 5, a core rod 6 and an adjuster 7; the housing 4 comprises a crown 8 and a tang 9; the crown 8 and the tail 9 are connected through a plurality of tracks 10; the moving block 5 is positioned between the crown 8 and the shank tail 9, and a plurality of first bulges 11 and a plurality of second bulges 12 are arranged on the moving block 5; the first protrusion 11 is engaged with the track 10, so that the moving block 5 can slide on the track 10; the second bulge 12 is provided with threads; one end of the core rod 6 is inserted into the crown 8, and the other end of the core rod is inserted into the moving block 5, so that the moving block 5 can slide on the track 10 along the core rod 6; the adjuster 7 is in a cylindrical shape with openings at two ends, the adjuster 7 is wrapped on the outer sides of the track 10 and the moving block 5, and the inner wall of the adjuster 7 is provided with threads matched with the second protrusions 12, so that the moving block 5 can slide on the track 10 along the core rod 6 along with the rotation of the adjuster 7;
the pushing device 2 comprises a guide wire 13 and a hypotube 14; the guide wire 13 comprises a first equal-diameter core wire section 15, a reducing core wire section 16, a second equal-diameter core wire section 17 and a tip 18 from the proximal end to the distal end in sequence; a plurality of pairs of cut depressions 19 are uniformly distributed on the diameter-variable core wire section 16 along the axial direction, two depressions 19 of the same pair are symmetrically arranged about the axis of the diameter-variable core wire section 16, and two adjacent pairs of depressions 19 are arranged in a staggered manner; the proximal end of the first isometric core wire section 15 is fixed on the core rod 6, and the distal end of the first isometric core wire section extends out of the shell 4 from the handle head 8 and extends to the embolectomy support 3; the reducing core wire section 16 penetrates through the bolt taking support 3; the hypotube 14 is wrapped outside the first isodiametric core wire segment 15, so that the guide wire 13 can move in the hypotube 14, the proximal end of the hypotube 14 is fixed on the moving block 5, and the distal end of the hypotube 14 extends out of the shell 4 from the handle 8 and extends to the embolectomy stent 3;
the proximal end of the thrombus taking support 3 is fixed on the distal end of the hypotube 14, and the distal end is fixed on the reducing core wire section 16, so that the thrombus taking support 3 can expand and contract along with the sliding of the moving block 5.
Preferably, the proximal end of the thrombectomy stent 3 is fixed to the distal end of the hypotube 14, and the distal end is fixed to the boundary between the variable diameter core wire segment 16 and the second equal diameter core wire segment 17.
Preferably, a first developing ring 20 and a second developing ring 21 are arranged on the guide wire 13; the first developing ring 20 is positioned at the joint of the far end of the bolt taking bracket 3 and the reducing core wire section 16; the second developing ring 21 is positioned at the joint of the proximal end of the embolectomy stent 3 and the distal end of the hypotube 14.
Preferably, the first developing ring 20 and the second developing ring 21 are made of platinum-iridium alloy material; the first developing ring 20 is welded or optically fixed on the bolt taking bracket 3 and the reducing core wire section 16 by using an optical fixing glue; the second developing ring 21 is welded or optically fixed on the bolt taking bracket 3 by using an optical cement glue.
Preferably, the maximum outer diameter of the first and second developing rings 20 and 21 is not more than 0.64 mm.
Preferably, the embolectomy device comprises a scale ring 22; the scale ring 22 is wrapped around the track 10 and the moving block 5, and the scale ring 22 is located between the shank 9 and the adjuster 7.
Preferably, the number of the rails 10 is two, and the two rails 10 are arranged opposite to each other at 180 °.
Preferably, the thrombus removal support 3 is of a net structure.
Preferably, the embolectomy stent 3 is formed by weaving 48 ingots of nickel-titanium shape memory alloy round wires with the wire diameter of 0.04mm, and the weaving density is 45PPI at the head end and 57PPI at the middle section.
Preferably, the embolectomy support 3 is formed by weaving 48 ingots of nickel-titanium shape memory alloy round wires with the wire diameter of 0.04mm in a 2-lap mode.
Preferably, the embolectomy support 3 is formed by weaving 48 ingots of nickel-titanium shape memory alloy round wires with the wire diameter of 0.04mm in a 2-lap mode, and 2-3 of the 48 ingots of nickel-titanium shape memory alloy wires are replaced by platinum tungsten wires.
Preferably, the platinum tungsten wire is a developable platinum tungsten wire.
Preferably, the platinum tungsten wire is PtW 8% platinum tungsten wire.
Preferably, the thrombectomy stent 3 has a length of 40mm in a fully contracted state and 30mm in a fully expanded state.
Preferably, the radial support force of the embolic stent 3 remains constant during expansion.
Preferably, the inner surface and the outer surface of the thrombus removal support 3 are both provided with heparin coatings.
Preferably, the hypotube 14 is a four-way hypotube formed by laser cutting a high elastic shape memory alloy tube.
Preferably, the high-elasticity shape memory alloy tube is a high-elasticity nickel-titanium shape memory alloy tube.
Preferably, the hypotube 14 has an outer diameter of 0.38mm, an inner diameter of 0.15mm, and a length of 200 cm.
Preferably, the cut length of the hypotube 14 is 45 cm.
Preferably, the cutting pattern of the recesses 19 is a four-way cut with a cutting taper of 0.15 °, the length of the individual recesses 19 is 0.1mm, and the distance between each recess 19 is 0.05 mm.
Preferably, two adjacent pairs of recesses 19 are staggered by 180 °.
Preferably, the recess 19 is annular in cross-section.
Preferably, the depressions 19 are distributed at a position on the variable diameter core wire section 16 which is 0.5mm away from the connection point of the first constant diameter core wire section 15 and the variable diameter core wire section 16.
Preferably, the tip 18 has a straight section 24 and a cut-off sharpened section 25 from the distal end to the proximal end, and the diameter of the sharpened section 25 is gradually reduced from the proximal end to the distal end.
Preferably, the grinding taper of the tapered section 25 is 0.6 ° and the length is 4 mm.
Preferably, the straight section 24 has an outer diameter of 0.07mm and a length of 8 mm.
Preferably, the first isodiametric core filament section 15 has a hydrophobic coating on the surface.
Preferably, the thickness of the hydrophobic coating on the surface of the first isodiametric core wire section 15 is 0.004-0.010 mm.
Preferably, the hydrophobic coating on the surface of the first isodiametric core filament section 15 is a green PTFE hydrophobic coating.
Preferably, the material of the first isodiametric core wire section 15 is SS304 stainless steel.
Preferably, the first isodiametric core wire section 15 has an outer diameter of 0.14mm and a length of 200 mm.
Preferably, the surface of the reducing core wire section 16 is provided with a hydrophilic coating.
Preferably, the hydrophilic coating on the surface of the reducing core wire section 16 is a PVP-polyvinylpyrrolidone hydrophilic coating.
Preferably, the thickness of the hydrophilic coating on the surface of the reducing core wire section 16 is 0.004-0.010 mm.
Preferably, the variable diameter core wire section 16 is made of nitinol.
Preferably, the reducing core wire section 16 has an outer diameter of 0.14mm and a length of 40 mm.
Preferably, the first constant diameter core wire section 15 and the reducing core wire section 16 are connected with each other at a firmness of not less than 10N.
Preferably, the second isodiametric core wire section 17 has a hydrophilic coating on the surface.
Preferably, the thickness of the hydrophilic coating on the surface of the second equal-diameter core wire section 17 is 0.004-0.010 mm.
Preferably, the hydrophilic coating on the surface of the second equant core wire section 17 is a PVP-polyvinylpyrrolidone hydrophilic coating.
Preferably, the second isodiametric core wire section 17 is made of nickel-titanium alloy.
Preferably, the second equal-diameter core wire section 17 has an outer diameter of 0.14mm and a length of 10 mm.
Preferably, the tip 18 is made of nitinol.
Preferably, the reducing core wire section 16, the second equal-diameter core wire section 17 and the tip 18 are cut from the same nitinol strip.
Preferably, the tip 18 is provided with a spring ring 23.
Preferably, both ends of the spring ring 23 are respectively welded or light-cured on the tip 18, and the welded or light-cured part is smooth and burr-free, and the maximum outer diameter of the welded or light-cured part does not exceed the outer diameter of the spring ring 23.
Preferably, the proximal bottom of the spring ring 23 is conical, and the distal top is arc-shaped.
Preferably, the spring ring 23 has a hydrophilic coating on its surface.
Preferably, the thickness of the hydrophilic coating on the surface of the spring ring 23 is 0.004-0.010 mm.
Preferably, the hydrophilic coating on the surface of the spring ring 23 is a PVP-polyvinylpyrrolidone hydrophilic coating.
Preferably, the spring ring 23 is a platinum-nickel alloy material that is radiographically developable.
Preferably, the spring ring 23 has a length of 12mm, an outer diameter of 0.25mm and an inner diameter of 0.16 mm.
Preferably, the moving distance of the moving block 5 is 0 to 10 mm.
The tolerance of the sizes of all parts of the embolectomy device is 0-5%.
Example 2: embolectomy method
The thrombus removal device of example 1 was used, and the specific procedure was as follows:
when the thrombus is taken, an operator uses the microcatheter to convey the thrombus taking support 3 to a position 2-3 cm away from the near end of a lesion position, the thrombus taking support 3 is continuously pushed to be conveyed to the lesion position, the thrombus taking support 3 penetrates through the thrombus through the spring ring 23, and the distance between the second developing ring 21 of the thrombus taking support 3 and the far end of the thrombus is 2-3 cm (the operator can adjust the position according to actual requirements); an operator holds the handle tail 9 with the left hand, the right hand holds the operation adjuster 7 to rotate slowly to push the moving block 5, the moving block 5 drives the hypotube 14 to slide axially towards a pathological change direction, the hypotube 14 is fixed with the second developing ring 21, the embolectomy stent 3 can be expanded when the hypotube 14 slides axially, the operator can adjust the expanded size of the embolectomy stent 3 according to the size of a pathological change blood vessel, the embolectomy stent 3 is slowly withdrawn after the embolectomy stent 3 is adjusted to a proper size, the embolectomy stent 3 is embedded into thrombus, the thrombus is cut, thrombus fragments enter an inner cavity gap of the embolectomy stent 3 through a mesh grid of the embolectomy stent 3, and the thrombus fragments cannot flow to the blood vessel at the far end through the mesh grid due to the fact that the weaving density at the far end of the embolectomy stent 3 is only 45PPI, and therefore the far end protection effect is achieved. The operator uses the handle 1 to move the thrombus removal support 3 out of the body, and thrombus removal is completed.
Although the present invention has been described with reference to the preferred embodiments, it should be understood that various changes and modifications can be made therein by those skilled in the art without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (10)
1. The thrombus taking device is characterized by comprising a handle, a pushing device and a thrombus taking support;
the handle comprises a shell, a moving block, a core rod and an adjuster; the shell comprises a crown and a tail; the handle head and the handle tail are connected through a plurality of tracks; the moving block is positioned between the crown and the tail, and a plurality of first bulges and a plurality of second bulges are arranged on the moving block; the first bulges are matched with the track, so that the moving block can slide on the track; the second bulge is provided with threads; one end of the core rod is inserted into the crown, and the other end of the core rod is inserted into the moving block, so that the moving block can slide on the track along the core rod; the adjuster is in a cylindrical shape with openings at two ends, the adjuster is wrapped on the outer sides of the track and the moving block, and the inner wall of the adjuster is provided with threads matched with the second bulges, so that the moving block can slide on the track along the core rod along with the rotation of the adjuster;
the pushing device comprises a guide wire and a hypotube; the guide wire comprises a first equal-diameter core wire section, a diameter-variable core wire section, a second equal-diameter core wire section and a tip end from a near end to a far end in sequence; a plurality of pairs of depressions formed by cutting are uniformly distributed on the diameter-variable core wire section along the axial direction, two depressions of the same pair are symmetrically arranged about the axis of the diameter-variable core wire section, and two adjacent pairs of depressions are arranged in a staggered manner; the proximal end of the first isodiametric core wire section is fixed on the core rod, and the distal end of the first isodiametric core wire section extends out of the shell from the crown and extends to the bolt taking support; the reducing core wire section penetrates through the plug taking support; the hypotube is wrapped outside the first isodiametric core wire section, so that the guide wire can move in the hypotube, the near end of the hypotube is fixed on the moving block, and the far end of the hypotube extends out of the shell from the handle head and extends to the embolectomy support;
the proximal end of the thrombus taking support is fixed on the distal end of the hypotube, and the distal end of the thrombus taking support is fixed on the reducing core wire section, so that the thrombus taking support can expand and contract along with the sliding of the moving block.
2. The embolectomy device of claim 1, wherein the guidewire is provided with a first visualization ring and a second visualization ring; the first developing ring is positioned at the joint of the distal end of the bolt taking bracket and the reducing core wire section; the second developing ring is positioned at the joint of the proximal end of the thrombus taking support and the distal end of the hypotube.
3. A embolectomy device as claimed in claim 1 or 2, wherein the embolectomy device comprises a graduated ring; the scale ring is wrapped on the outer sides of the track and the moving block and is located between the handle tail and the adjuster.
4. An embolectomy device according to any of claims 1-3 wherein the embolectomy support is a mesh structure.
5. The embolectomy device of any of claims 1-4, wherein the embolectomy support is woven from 48-piece round wire of nickel-titanium shape memory alloy with a wire diameter of 0.04 mm; or the thrombus taking support is woven by 48 ingots of nickel-titanium shape memory alloy round wires with the wire diameter of 0.04mm, and 2-3 of the 48 ingots of nickel-titanium shape memory alloy wires are replaced by platinum tungsten wires.
6. An embolectomy device according to any of claims 1 to 5 wherein the depressions are cut in a four-way manner with a cutting taper of 0.15 °, the length of the individual depressions 19 is 0.1mm and the distance between each depression 19 is 0.05 mm.
7. An embolectomy device as claimed in any of claims 1 to 6 wherein adjacent pairs of depressions are staggered by 180 °.
8. An embolectomy device as claimed in any of claims 1 to 7 wherein the cross-section of the depression is annular.
9. The embolectomy device of any of claims 1-8 wherein the tip is a straight section and a cut and sharpened section from the distal end to the proximal end, respectively, the diameter of the sharpened section gradually decreasing from the proximal end to the distal end.
10. An embolectomy device as claimed in any of claims 1-9 wherein the tip is provided with a spring ring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011438406.XA CN112674835B (en) | 2020-12-07 | 2020-12-07 | Thrombus taking device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011438406.XA CN112674835B (en) | 2020-12-07 | 2020-12-07 | Thrombus taking device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112674835A true CN112674835A (en) | 2021-04-20 |
| CN112674835B CN112674835B (en) | 2022-04-08 |
Family
ID=75447552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011438406.XA Active CN112674835B (en) | 2020-12-07 | 2020-12-07 | Thrombus taking device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112674835B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113693677A (en) * | 2021-08-25 | 2021-11-26 | 北京管桥医疗科技有限公司 | Embolectomy system for treating large-size vascular embolism and use method thereof |
| CN114159124A (en) * | 2021-08-30 | 2022-03-11 | 北京泰杰伟业科技有限公司 | Adjustable twisting bolt taking device |
| CN115414087A (en) * | 2022-05-24 | 2022-12-02 | 上海玮琅医疗科技有限公司 | Dilator assembly |
| WO2023051257A1 (en) * | 2021-09-28 | 2023-04-06 | 先健科技(深圳)有限公司 | Thrombectomy apparatus |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103284775A (en) * | 2013-06-04 | 2013-09-11 | 加奇生物科技(上海)有限公司 | Encephalic thrombosis removing device |
| US20160120565A1 (en) * | 2014-11-04 | 2016-05-05 | Terumo Kabushiki Kaisha | Medical device and treatment method |
| CN107582130A (en) * | 2017-09-25 | 2018-01-16 | 杭州巴泰医疗器械有限公司 | A kind of blood vessel expansion appliance of the tie bracket and application of non-built-in mode the foley's tube tie bracket |
| CN108378904A (en) * | 2018-01-11 | 2018-08-10 | 恩脉（上海）医疗科技有限公司 | Interventional therapy device |
| CN108904008A (en) * | 2018-08-14 | 2018-11-30 | 上海微密医疗科技有限公司 | A kind of controllable cerebrovascular takes bolt bracket and transport control system |
| CN111447967A (en) * | 2018-05-09 | 2020-07-24 | 朝日英达科株式会社 | Medical tube |
| CN111956934A (en) * | 2020-08-31 | 2020-11-20 | 尚华 | Medical guide wire |
-
2020
- 2020-12-07 CN CN202011438406.XA patent/CN112674835B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103284775A (en) * | 2013-06-04 | 2013-09-11 | 加奇生物科技(上海)有限公司 | Encephalic thrombosis removing device |
| US20160120565A1 (en) * | 2014-11-04 | 2016-05-05 | Terumo Kabushiki Kaisha | Medical device and treatment method |
| US20160120569A1 (en) * | 2014-11-04 | 2016-05-05 | Terumo Kabushiki Kaisha | Medical device and treatment method |
| CN107582130A (en) * | 2017-09-25 | 2018-01-16 | 杭州巴泰医疗器械有限公司 | A kind of blood vessel expansion appliance of the tie bracket and application of non-built-in mode the foley's tube tie bracket |
| CN108378904A (en) * | 2018-01-11 | 2018-08-10 | 恩脉（上海）医疗科技有限公司 | Interventional therapy device |
| CN111447967A (en) * | 2018-05-09 | 2020-07-24 | 朝日英达科株式会社 | Medical tube |
| CN108904008A (en) * | 2018-08-14 | 2018-11-30 | 上海微密医疗科技有限公司 | A kind of controllable cerebrovascular takes bolt bracket and transport control system |
| CN111956934A (en) * | 2020-08-31 | 2020-11-20 | 尚华 | Medical guide wire |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113693677A (en) * | 2021-08-25 | 2021-11-26 | 北京管桥医疗科技有限公司 | Embolectomy system for treating large-size vascular embolism and use method thereof |
| CN114159124A (en) * | 2021-08-30 | 2022-03-11 | 北京泰杰伟业科技有限公司 | Adjustable twisting bolt taking device |
| WO2023051257A1 (en) * | 2021-09-28 | 2023-04-06 | 先健科技(深圳)有限公司 | Thrombectomy apparatus |
| CN115414087A (en) * | 2022-05-24 | 2022-12-02 | 上海玮琅医疗科技有限公司 | Dilator assembly |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112674835B (en) | 2022-04-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112674835B (en) | Thrombus taking device | |
| KR102218868B1 (en) | Blood clot removal device for cerebral infarction treatment | |
| CA3093697C (en) | Flow protection device for ischemic stroke treatment | |
| US10265085B2 (en) | System and device for engulfing thrombi | |
| CN107205751B (en) | Thrombectomy device and system for removing vascular thrombi from blood vessels | |
| KR20210097034A (en) | Dual layer icad device | |
| EP2442860B1 (en) | Apparatus for allowing blood flow through an occluded vessel | |
| CN107212913B (en) | Support thrombectomy device with thrombus capture component | |
| KR20180075643A (en) | Embolization device and related method having blood flow limitation | |
| US20150018860A1 (en) | Methods and apparatus for treating small vessel thromboembolisms | |
| CN105662533B (en) | Blood vessel thrombus taking device with spiral structure and thrombus therapeutic instrument thereof | |
| EP2262567A1 (en) | Device for treating occlusions, and method for treating occluded vessels | |
| CN112089477A (en) | Basket type thrombus removing device | |
| US11937836B2 (en) | Clot retrieval system with expandable clot engaging framework | |
| JP7431252B2 (en) | Blockage recovery device | |
| CN111493974B (en) | Adjustable thrombus extraction device and manufacturing method thereof | |
| US20230027756A1 (en) | Clot Retrieval Device for Ischemic Stroke Treatment | |
| CN214157448U (en) | Thrombus taking device | |
| KR20210158348A (en) | A clot retrieval device for removing clot from a blood vessel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |