CN112661806A - Stable form polypeptide preparation facilities - Google Patents
Stable form polypeptide preparation facilities Download PDFInfo
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- CN112661806A CN112661806A CN202110278267.7A CN202110278267A CN112661806A CN 112661806 A CN112661806 A CN 112661806A CN 202110278267 A CN202110278267 A CN 202110278267A CN 112661806 A CN112661806 A CN 112661806A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
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Abstract
The invention relates to the technical field of polypeptide preparation, and discloses a stable polypeptide preparation device, which comprises a bearing trolley and a mixing assembly, wherein the mixing assembly comprises a driving piece and a plurality of bearing trays; the bottom of the placing box is provided with a plurality of through holes corresponding to the plurality of bearing plates, and each through hole is internally provided with a reaction vessel for containing the polypeptide; a wall scraping assembly, the wall scraping assembly comprising: the lifting piece is arranged on the inner wall of the placing box; the scraping plate is arranged below the lifting piece, and when the polypeptide solid-phase carrier is adhered to the inner wall of the reaction vessel, the polypeptide solid-phase carrier adhered to the inner wall of the reaction vessel is scraped off by pressing the scraping plate; then through the pencil with scrape off the board and suspend in the polypeptide solid phase carrier top in the reaction household utensils and leave the space again, when the bearing trolley was jolting in the removal production, because the scraping board that sets up can avoid polypeptide solid phase carrier to rock at the reaction household utensils because of jolting and lead to polypeptide solid phase carrier to adhere again at the inner wall of reaction household utensils.
Description
Technical Field
The invention relates to the technical field of polypeptide preparation, in particular to a stable polypeptide preparation device.
Background
The synthesis of the polypeptide is carried out in a closed explosion-proof glass reactor, so that amino acid is continuously added, reacted and synthesized according to a known sequence, and a polypeptide carrier is finally obtained through operation.
To this end, chinese patent No. CN112044375A includes a machine body and a preparation cavity, the front end of the machine body is provided with the preparation cavity, the front end of the coupler is provided with a main rotating rod, the main rotating rod extends into the inside of the limiting column sleeve, the connecting column is movably connected to the other end of the limiting column sleeve, the motor is started to make the cam rotate, the moving column arranged on the surface of the cam pushes the bottom plate, the effect of vibrating the experimental glass bottle is achieved, the polypeptide-solid phase carrier is not stuck on the surface of the experimental glass bottle, and the preparation efficiency is improved.
The polypeptide-solid phase carrier adhered to the surface of the experimental glass bottle is separated off by shaking the device; but has the following technical problems:
firstly, the force of vibration is not capable of ensuring that all the polypeptide-solid phase carriers adhered to the surface of the experimental glass bottle can be shaken off, and if the polypeptide-solid phase carriers with higher adhesion are encountered, the polypeptide-solid phase carriers cannot be shaken off;
secondly, during the transportation process of the polypeptide-solid phase carrier in the experiment glass bottle, the polypeptide-solid phase carrier in the experiment glass bottle is easy to adhere to the surface of the experiment glass bottle again due to the vibration generated by the trolley, so that the preparation efficiency is influenced.
Disclosure of Invention
The embodiment of the invention provides a stable polypeptide preparation device, which comprises:
a bearing trolley is arranged on the base plate,
the mixing component is lapped on the bearing trolley and comprises a driving part and a plurality of bearing trays, the driving part is positioned beside the bearing trolley and can drive the plurality of bearing trays to rotate simultaneously;
the bottom of the placing box is provided with a plurality of through holes corresponding to the plurality of bearing plates, each through hole is internally provided with a reaction vessel for containing polypeptide, and the top of the placing box is provided with a box cover for sealing the inside of the placing box;
the wall scraping assembly is arranged in the placing box;
wherein the wall scraping assembly comprises:
the lifting piece is arranged on the inner wall of the placing box;
the scraping plate is arranged below the lifting piece, the outer diameter of the scraping plate is the same as the inner diameter of the reaction vessel, and the scraping plate is used for scraping the inner wall of the reaction vessel.
In a preferred embodiment of the invention, the driving member comprises a driving motor, a driving wheel and a driving wheel, the driving motor is mounted on the outer side wall of the carrying trolley, the driving wheel is sleeved on an output shaft of the driving motor, the driving wheel is mounted on one of the bearing trays, the driving wheel and the driving wheel are in transmission fit through a belt, the bearing trays respectively comprise a linkage gear and an anti-slip pad, all the linkage gears can rotate in the placing box, every two adjacent linkage gears are mutually meshed, the anti-slip pad is mounted on the linkage gears, and an anti-slip groove is formed in the anti-slip pad.
In a preferred embodiment of the present invention, the outer side wall of the placing box is provided with a feeding member corresponding to each reaction vessel, each feeding member includes a feeding pipe, a storage box and a proportioning roller, one end of the feeding pipe extends to the upper side of the reaction vessel, the other end of the feeding pipe is communicated with the storage box, the proportioning roller is disposed in the feeding pipe, the proportioning roller is provided with a proportioning tank, and a proportioning motor for driving the proportioning roller to rotate is disposed beside the feeding pipe.
In a preferred embodiment of the invention, the bottom of each material passing pipeline is provided with a rolling gear, the bottom of each material passing pipeline is provided with a tooth socket meshed with the rolling gear, the side of the placing box is provided with a rolling rod and a rolling motor, the rolling rod is connected with all the rolling gears, one end of the rolling rod is fixedly connected with an output shaft of the rolling motor, and the other end of the rolling rod can be rotatably arranged on the outer side wall of the placing box.
In a preferred embodiment of the present invention, the pulling member is provided with a plurality of pulling members corresponding to a plurality of reaction vessels, each pulling member includes a pulling motor and a pulling roller, the pulling roller is mounted on an output shaft of the pulling motor, the pulling roller is provided with two pulling wheels fixedly connected thereto, the two pulling wheels are arranged at intervals, a wire harness for pulling the scraping plate is wound on each of the two pulling wheels, the placing box is provided with a lap joint rod for receiving the wire harness, the lap joint rod is provided with a wire harness block corresponding to each wire harness, and each wire harness block can be slidably fitted on the lap joint rod.
In a preferred embodiment of the invention, the scraping plate is provided with a push-pull rod and a scraping block, the bottom of the scraping block is provided with a containing groove for containing the scraping block, the depth of the containing groove is equal to the thickness of the scraping block, the scraping block is positioned at the bottom of the scraping block, the push-pull rod is vertically arranged, the bottom of the push-pull rod penetrates through the scraping plate and then is fixedly connected with the bottom of the push-pull rod, the top of the scraping plate is provided with two clamping blocks for limiting the push-pull rod, the two clamping blocks are symmetrically arranged, and the rear ends of the two clamping blocks are provided with pressurizing springs.
In a preferred embodiment of the present invention, the push-pull rod is provided with a scale groove, and the top of the push-pull rod is provided with a handle.
In a preferred embodiment of the invention, a vibration damping pad is arranged between the bearing trolley and the bottom of the placing box, and four self-locking wheels are arranged at the bottom of the bearing trolley.
The embodiment of the invention adopts at least one technical scheme which can achieve the following beneficial effects:
firstly, when polypeptide solid-phase carriers adhered to the inner wall of a reaction vessel exist after polypeptide preparation is finished, the polypeptide solid-phase carriers adhered to the inner wall of the reaction vessel are scraped off by pressing a scraping plate; then through the pencil with scrape off the board and suspend in the polypeptide solid phase carrier top in the reaction household utensils and leave the space again, when the bearing trolley was jolting in the removal production, because the scraping board that sets up can avoid polypeptide solid phase carrier to rock at the reaction household utensils because of jolting and lead to polypeptide solid phase carrier to adhere again at the inner wall of reaction household utensils.
Secondly, when the polypeptide solid phase carriers are transported to a designated position, the push-pull rod is pushed to enable the scraping block to slide out of the containing groove, the push-pull rod is rotated to enable the scraping block to move at the bottom of the scraping plate, and the polypeptide solid phase carriers adhered to the scraping plate are scraped, so that the situation that the polypeptide solid phase carriers are adhered to the bottom of the scraping plate due to transportation shaking and the preparation efficiency is influenced is avoided; after the push-pull rod rotates 360 degrees, the scraping block is arranged under the containing groove, the push-pull rod is pulled to enable the scraping block to enter the containing groove, the polypeptide solid-phase carriers adhered to the scraping block are removed, the polypeptide solid-phase carriers adhered to the scraping block drop into the reaction vessel, and the polypeptide solid-phase carriers are prevented from being adhered to the scraping block when the polypeptide solid-phase carriers at the bottom of the scraping plate are removed by the scraping block.
And thirdly, the storage box is used for storing additives for improving the stability of the polypeptide solid phase carrier, when the polypeptide solid phase carrier is prepared, the proportioning motor drives the proportioning roller to rotate, the additives in the proportioning tank enter the material passing pipeline and are conveyed into the reaction vessel due to the rotation of the proportioning roller, and the additives react with the polypeptide solid phase carrier to improve the stability of the polypeptide solid phase carrier.
Fourthly, the driving motor who sets up drives drive wheel and driving wheel synchronous motion through the belt to it is rotatory to drive all linkage gears, and it is rotatory to drive the reaction household utensils on the slipmat when linkage gear is rotatory, can accelerate polypeptide solid phase carrier's preparation when the reaction household utensils are rotatory, and when the additive got into in the reaction household utensils, pivoted reaction household utensils can accelerate additive and polypeptide solid phase carrier and mix, in order to improve the efficiency of preparation.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention and not to limit the invention. In the drawings:
FIG. 1 is a schematic perspective view of the present invention;
FIG. 2 is a cross-sectional view of the present invention;
FIG. 3 is a partial perspective view of the first embodiment of the present invention;
FIG. 4 is a partial perspective view of the second embodiment of the present invention;
fig. 5 is a schematic perspective view of the scraping plate of the present invention;
fig. 6 is a cross-sectional view of a doctoring plate of the present invention;
FIG. 7 is a partial schematic view of the driving member of the present invention;
FIG. 8 is a cross-sectional view of a charging member of the present invention;
fig. 9 is an enlarged schematic view of a portion a in fig. 1.
In the drawings:
1. a mixing assembly; 11. a drive member; 111. a drive motor; 112. a drive wheel; 113. driving the wheel;
12. a support tray; 121. a linkage gear; 122. a non-slip mat;
2. placing a box;
3. a reaction vessel;
4. a wall scraping assembly; 41. a pulling member; 411. lifting a motor; 412. a pulling roll; 413. lifting and pulling wheels; 414. a lap joint rod; 415. a wire harness block;
42. scraping the plate; 421. a push-pull rod; 422. a scraper block; 423. accommodating grooves; 424. a clamping block; 425. a pressurizing spring;
5. feeding parts; 51. a material passing pipeline; 52. a material storage box; 53. a dosing roller; 54. a batching tank; 55. a rolling gear; 56. a roll bar; 57. a rolling motor; 58. a dosing motor.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be clearly and completely described below with reference to the specific embodiments of the present invention and the accompanying drawings. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The technical solutions provided by the embodiments of the present invention are described in detail below with reference to the accompanying drawings.
In this example, as shown in FIGS. 1 to 9, a stabilized polypeptide preparation apparatus includes:
a bearing trolley is arranged on the base plate,
the mixing component 1 is connected to the bearing trolley in a lap joint mode, the mixing component 1 comprises a driving part 11 and a plurality of bearing trays 12, the driving part 11 is located beside the bearing trolley, and the driving part 11 can drive the plurality of bearing trays 12 to rotate simultaneously;
the device comprises a placing box 2, wherein a plurality of through holes are formed in the bottom of the placing box 2 corresponding to a plurality of bearing plates 12, a reaction vessel 3 for containing polypeptide is arranged in each through hole, and a box cover for sealing the inside of the placing box 2 is arranged at the top of the placing box 2;
the wall scraping component 4 is arranged in the placing box 2;
wherein the wall scraping assembly 4 comprises:
a lifting member 41 provided on the inner wall of the placing case 2;
and a scraping plate 42 disposed below the pulling member 41, wherein the outer diameter of the scraping plate 42 is the same as the inner diameter of the reaction vessel 3, and the scraping plate 42 is used for scraping the inner wall of the reaction vessel 3.
Specifically, as shown in fig. 2 and 7, the driving member 11 includes a driving motor 111, a driving wheel 112 and a driving wheel 113, the driving motor 111 is installed on the outer sidewall of the carrying trolley, the driving wheel 112 is sleeved on the output shaft of the driving motor 111, the driving wheel 113 is installed on one of the carrying trays 12, the driving wheel 112 and the driving wheel 113 are in transmission fit through a belt, a plurality of the carrying trays 12 include linkage gears 121 and non-slip mats 122, all the linkage gears 121 can rotate in the placing box 2, every two adjacent linkage gears 121 are engaged with each other, the non-slip mats 122 are installed on the linkage gears 121, non-slip grooves are formed in the non-slip mats 122, the driving motor 111 drives the driving wheel 112 and the driving wheel 113 to move synchronously through the belt to drive all the linkage gears 121 to rotate, when the linkage gears 121 rotate, the reaction vessels 3 on the non-slip mats 122 are driven to rotate, the preparation of the polypeptide solid phase carrier can be accelerated when the reaction vessel 3 rotates, and when the additive enters the reaction vessel 3, the rotating reaction vessel 3 can accelerate the mixing of the additive and the polypeptide solid phase carrier, so that the preparation efficiency is improved.
Specifically, the outer side wall of the placing box 2 is provided with feeding members 5 corresponding to each reaction vessel 3, each feeding member 5 includes a feeding pipe 51, a storage box 52 and a proportioning roller 53, one end of the feeding pipe 51 extends to the upper side of the reaction vessel 3, the other end of the feeding pipe 51 is communicated with the storage box 52, the proportioning roller 53 is arranged in the feeding pipe 51, a proportioning groove 54 is arranged on the proportioning roller 53, a proportioning motor 58 for driving the proportioning roller 53 to rotate is arranged beside the feeding pipe 51, the storage box 52 is used for storing an additive for improving the stability of the polypeptide solid phase carrier, when the polypeptide solid phase carrier is prepared, the proportioning motor 58 drives the proportioning roller 53 to rotate, the additive in the proportioning groove 54 enters the feeding pipe 51 due to the rotation of the proportioning roller 53 and enters the reaction vessel 3 to react with the polypeptide solid phase carrier, so as to improve the stability of the polypeptide solid phase carrier, the dosing chute 54 on the dosing roller 53 enables dosing.
Specifically, as shown in fig. 8 and 9, a rolling gear 55 is disposed at the bottom of each material passing pipe 51, a tooth groove meshed with the rolling gear 55 is disposed at the bottom of the material passing pipe 51, a rolling rod 56 and a rolling motor 57 are disposed beside the placing box 2, the rolling rod 56 is connected to all the rolling gears 55, one end of the rolling rod 56 is fixedly connected to an output shaft of the rolling motor 57, the other end of the rolling rod 56 is rotatably mounted on an outer side wall of the placing box 2, the rolling motor 57 drives the rolling gear 55 to rotate through the rolling rod 56, and the bottom of the material passing pipe 51 moves towards the reaction vessel 3 through the rolling gear 55, so as to prevent the additive in the material passing pipe 51 from scattering due to the fact that the additive is far away from the reaction vessel 3.
Specifically, as shown in fig. 3 and 4, a plurality of pulling members 41 are provided corresponding to a plurality of reaction vessels 3, each pulling member 41 includes a pulling motor 411 and a pulling roller 412, the pulling roller 412 is mounted on an output shaft of the pulling motor 411, two pulling wheels 413 fixedly connected to the pulling roller 412 are provided on the pulling roller 412, the two pulling wheels 413 are provided at intervals, a wire harness for pulling the scraping plate 42 is wound on each of the two pulling wheels 413, a lapping rod 414 for receiving the wire harness is provided in the placing box 2, a wire harness block 415 is provided on the lapping rod 414 corresponding to each wire harness, each wire harness block 415 can be slidably fitted on the lapping rod 414, the pulling motor 411 can control the rotation of the wire harness on the corresponding pulling wheel 413 through the pulling roller 412, when the wire harness rotates on the pulling wheel 413, the distance between the scraping plate 42 and the reaction vessel 3 can be controlled, when the reaction vessel 3 rotates, scrape off board 42 through pencil control and suspend directly over reaction household utensils 3 to drive when avoiding reaction household utensils 3 to rotate and scrape off board 42 and rotate, after the polypeptide preparation in the reaction household utensils 3 is accomplished, scrape off board 42 and get into in the reaction household utensils 3 through pencil control.
Specifically, as shown in fig. 5 and fig. 6, a push-pull rod 421 and a scraper block 422 are arranged on the scraper plate 42, an accommodating groove 423 for accommodating the scraper block 422 is arranged at the bottom of the scraper block 422, the depth of the accommodating groove 423 is equal to the thickness of the scraper block 422, the scraper block 422 is located at the bottom of the scraper block 422, the push-pull rod 421 is vertically arranged, the bottom of the push-pull rod 421 penetrates through the scraper plate 42 and is fixedly connected with the bottom of the push-pull rod 421, two clamping blocks 424 for limiting the push-pull rod 421 are arranged at the top of the scraper plate 42, the two clamping blocks 424 are symmetrically arranged, the rear ends of the two clamping blocks 424 are respectively provided with a pressurizing spring 425, when the polypeptide carrier is transported to a designated position, the scraper block 422 slides out of the accommodating groove 423 by manually pushing the push-pull rod 421, the scraper block 422 moves at the bottom of the scraper plate 42 by rotating the scraper rod 421, and scrapes the polypeptide solid-, the polypeptide solid phase carriers are prevented from being adhered to the bottom of the scraping plate 42 due to transportation shaking, so that the preparation efficiency is prevented from being influenced; after the push-pull rod 421 rotates 360 degrees, the scraping block 422 is disposed right below the accommodating groove 423, the push-pull rod 421 is pulled to make the scraping block 422 enter the accommodating groove 423, the polypeptide solid-phase carriers adhered to the scraping block 422 are removed, the polypeptide solid-phase carriers adhered to the scraping block 422 fall into the reaction vessel 3, and the polypeptide solid-phase carriers are prevented from adhering to the scraping block 422 when the scraping block 422 removes the polypeptide solid-phase carriers at the bottom of the scraping plate 42.
Specifically, as shown in fig. 5 and 6, a scale groove is formed on the push-pull rod 421, a grip is arranged on the top of the push-pull rod 421, the grip is arranged to facilitate movement of the push-pull rod 421, and the scale groove formed on the push-pull rod 421 can increase friction between the two clamping blocks 424 and the push-pull rod 421, so as to prevent the push-pull rod 421 from driving the scraper block 422 to move downward.
Specifically, a vibration damping pad is arranged between the bearing trolley and the bottom of the placing box 2, four self-locking wheels are arranged at the bottom of the bearing trolley, and the bearing trolley and the placing box 2 arranged on the bearing trolley are driven to move to any position through the four self-locking wheels.
The working principle of the invention;
after the preparation of the polypeptide solid phase carrier is completed, when the stability of the polypeptide solid phase carrier needs to be improved, the proportioning motor 58 drives the proportioning roller 53 to rotate, the additive in the proportioning tank 54 enters the material passing pipeline 51 due to the rotation of the proportioning roller 53 and enters the reaction vessel 3 to react with the polypeptide solid phase carrier, so as to improve the stability of the polypeptide solid phase carrier, after the additive enters the reaction vessel 3, the arranged driving motor 111 drives the driving wheel 112 and the driving wheel 113 to synchronously move through a belt so as to drive all the linkage gears 121 to rotate, when the linkage gears 121 rotate, the reaction vessel 3 on the anti-slip pad 122 is driven to rotate, the preparation of the polypeptide solid phase carrier can be accelerated when the reaction vessel 3 rotates, and when the additive enters the reaction vessel 3, the rotating reaction vessel 3 can accelerate the mixing of the additive and the polypeptide solid phase carrier so as to improve the preparation efficiency, the pulling motor 411 can control the pulling wheel 413 to rotate through the pulling roller 412, when the wire harness rotates on the lifting wheel 413, the distance between the scraping plate 42 and the reaction vessel 3 can be controlled, when the reaction vessel 3 rotates, the scraping plate 42 is controlled by the wire harness to be suspended right above the reaction vessel 3 so as to prevent the scraping plate 42 from rotating when the reaction vessel 3 rotates, after the reaction vessel 3 stops rotating, the scraping plate 42 is controlled by the wire harness to enter the reaction vessel 3 and keep a certain distance with polypeptide solid phase carriers in the reaction vessel 3, and when the polypeptide solid phase carriers are transported to a designated position, the push-pull rod 421 is pushed by a worker so that the scraping plate 42 scrapes the polypeptide solid phase carriers adhered to the inner wall of the reaction vessel 3 down into the reaction vessel 3; the clamping force of the two clamping blocks 422 is stronger, when the push-pull rod 421 is pushed to move downwards manually, the scraping plate 42 can be driven to move downwards synchronously, then the two clamping blocks 422 are shifted to enable the side walls of the two clamping blocks 422 to be abutted against the push-pull rod 421, the clamping force of the side walls of the two clamping blocks 422 on the push-pull rod 421 is reduced, the push-pull rod 421 can slide on the scraping plate 42 easily, the push-pull rod 421 is pushed again to enable the scraping block 422 to slide out of the accommodating groove 423, the push-pull rod 421 is rotated to enable the scraping block 422 to move at the bottom of the scraping plate 42, and polypeptide solid phase carriers adhered on the scraping plate 42 are scraped, so that the situation that a plurality of polypeptide solid phase carriers are adhered at the bottom of the scraping plate 42 due to transportation shaking is avoided, and the; after the push-pull rod 421 rotates 360 degrees, the scraping block 422 is disposed right below the accommodating groove 423, the push-pull rod 421 is pulled to make the scraping block 422 enter the accommodating groove 423, the polypeptide solid-phase carriers adhered to the scraping block 422 are removed, the polypeptide solid-phase carriers adhered to the scraping block 422 fall into the reaction vessel 3, and the polypeptide solid-phase carriers are prevented from adhering to the scraping block 422 when the scraping block 422 removes the polypeptide solid-phase carriers at the bottom of the scraping plate 42.
The above description is only an example of the present invention, and is not intended to limit the present invention. Various modifications and alterations to this invention will become apparent to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the scope of the claims of the present invention.
Claims (8)
1. A stable form polypeptide preparation facilities which characterized in that: the method comprises the following steps:
a bearing trolley is arranged on the base plate,
the mixing component (1) is lapped on the bearing trolley, the mixing component (1) comprises a driving part (11) and a plurality of bearing plates (12), the driving part (11) is located beside the bearing trolley, and the driving part (11) can drive the plurality of bearing plates (12) to rotate simultaneously;
the device comprises a placing box (2), wherein a plurality of through holes are formed in the bottom of the placing box (2) corresponding to a plurality of bearing plates (12), a reaction vessel (3) for containing polypeptide is arranged in each through hole, and a box cover for sealing the inside of the placing box (2) is arranged at the top of the placing box (2);
the wall scraping component (4) is arranged in the placing box (2);
wherein the wall scraping assembly (4) comprises:
a lifting piece (41) arranged on the inner wall of the placing box (2);
the scraping plate (42) is arranged below the lifting piece (41), the outer diameter of the scraping plate (42) is the same as the inner diameter of the reaction vessel (3), and the scraping plate (42) is used for scraping the inner wall of the reaction vessel (3).
2. A stabilized polypeptide preparation apparatus according to claim 1, wherein: the driving piece (11) comprises a driving motor (111), a driving wheel (112) and a driving wheel (113), the driving motor (111) is installed on the outer side wall of the bearing trolley, the driving wheel (112) is sleeved on an output shaft of the driving motor (111), the driving wheel (113) is installed on one of the bearing trays (12), the driving wheel (112) and the driving wheel (113) are matched through belt transmission, the bearing tray (12) comprises a linkage gear (121) and a non-slip mat (122), all the linkage gear (121) can rotate in the placing box (2), every two adjacent linkage gears (121) are mutually meshed, and the non-slip mat (122) is installed on the linkage gear (121) and is provided with a non-slip groove on the non-slip mat (122).
3. A stabilized polypeptide preparation apparatus according to claim 2, wherein: it all is equipped with feeding spare (5), every to correspond every reaction household utensils (3) on the lateral wall of placing case (2) feeding spare (5) all include material pipeline (51), storage case (52) and proportioning roller (53), the one end of crossing material pipeline (51) extends to the top of reaction household utensils (3), and the other end of crossing material pipeline (51) is linked together with storage case (52), in material pipeline (51) was arranged in proportioning roller (53), be equipped with batching groove (54) on proportioning roller (53), the side of crossing material pipeline (51) is equipped with drive proportioning roller (53) pivoted proportioning motor (58).
4. A stabilized polypeptide preparation apparatus according to claim 3, wherein: every the bottom of expecting pipeline (51) all is equipped with rolling gear (55) and the bottom of expecting pipeline (51) is equipped with the tooth's socket with rolling gear (55) meshing, and the side of placing case (2) is equipped with rolling rod (56) and rolling motor (57), rolling rod (56) and all rolling gear (55) are connected, and the one end and the output shaft fixed connection of rolling motor (57) of rolling rod (56), the other end of rolling rod (56) can be rotated install on the lateral wall of placing case (2).
5. A stabilized polypeptide preparation apparatus according to claim 4, wherein: the lifting and pulling device is characterized in that a plurality of lifting and pulling pieces (41) are arranged corresponding to a plurality of reaction vessels (3), each lifting and pulling piece (41) comprises a lifting and pulling motor (411) and a lifting and pulling roller (412), the lifting and pulling rollers (412) are installed on an output shaft of the lifting and pulling motor (411), two lifting and pulling wheels (413) fixedly connected with the lifting and pulling rollers (412) are arranged on the lifting and pulling rollers (412), the two lifting and pulling wheels (413) are arranged at intervals, wire harnesses used for lifting and pulling a scraping plate (42) are arranged on the two lifting and pulling wheels (413), a lapping rod (414) for bearing the wire harnesses is arranged in the placing box (2), wire harness blocks (415) are arranged on the lapping rod (414) corresponding to each wire harness, and each wire harness block (415) can be in sliding fit with the lapping rod (414).
6. A stabilized polypeptide preparation apparatus according to claim 1, wherein: the scraping plate (42) is provided with a push-pull rod (421) and a scraping block (422), the bottom of the scraping block (422) is provided with an accommodating groove (423) used for accommodating the scraping block (422), the depth of the accommodating groove (423) is equal to the thickness of the scraping block (422), the scraping block (422) is located at the bottom of the scraping block (422), the push-pull rod (421) is vertically arranged, the bottom of the push-pull rod (421) penetrates through the scraping plate (42) and then is fixedly connected with the bottom of the push-pull rod (421), the top of the scraping plate (42) is provided with two clamping blocks (424) used for limiting the push-pull rod (421), the two clamping blocks (424) are symmetrically arranged, and the rear ends of the two clamping blocks (424) are respectively provided with a pressurizing spring (425).
7. A stabilized polypeptide preparation apparatus according to claim 6, wherein: the push-pull rod (421) is provided with a scale groove, and the top of the push-pull rod (421) is provided with a grab handle.
8. A stabilized polypeptide preparation apparatus according to claim 1, wherein: a vibration damping pad is arranged between the bearing trolley and the bottom of the placing box (2), and four self-locking wheels are arranged at the bottom of the bearing trolley.
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| KR20040091829A (en) * | 2003-04-22 | 2004-11-02 | (주)인터페이스바이오텍 | Device for chemical synthesis |
| WO2008035962A1 (en) * | 2006-09-19 | 2008-03-27 | Fujifilm Manufacturing Europe B.V. | Process and device for the precipitation of an organic compound |
| CN106986916A (en) * | 2017-03-20 | 2017-07-28 | 珠海百世瑞生命科技有限公司 | Full automatic high efficiency solid phase peptide synthesizer and application method |
| CN111205348A (en) * | 2020-03-20 | 2020-05-29 | 安徽省国平药业有限公司 | Solid-phase synthesis method of long-chain polypeptide |
| CN112473602A (en) * | 2020-11-27 | 2021-03-12 | 陈月红 | Reation kettle for industrial chemicals convenient to inside clearance |
| CN112481100A (en) * | 2021-01-03 | 2021-03-12 | 西安蓝华飞腾生物科技有限公司 | Mesenchymal stem cell culture medium production system |
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| CN112661806B (en) | 2021-06-04 |
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