CN112635290B - Reflection type ion mobility spectrometer - Google Patents
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- 230000005012 migration Effects 0.000 claims abstract description 245
- 238000013508 migration Methods 0.000 claims abstract description 245
- 150000002500 ions Chemical class 0.000 claims abstract description 202
- 230000005684 electric field Effects 0.000 claims abstract description 59
- 238000001514 detection method Methods 0.000 claims abstract description 44
- 230000009471 action Effects 0.000 claims abstract description 33
- 239000002184 metal Substances 0.000 claims abstract description 25
- 238000012545 processing Methods 0.000 claims abstract description 25
- 238000001871 ion mobility spectroscopy Methods 0.000 claims abstract description 17
- 238000009792 diffusion process Methods 0.000 claims abstract description 13
- 230000035945 sensitivity Effects 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 11
- 230000008569 process Effects 0.000 claims abstract description 10
- 238000005516 engineering process Methods 0.000 claims abstract description 4
- 238000012546 transfer Methods 0.000 claims description 39
- 238000004458 analytical method Methods 0.000 claims description 7
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 238000000132 electrospray ionisation Methods 0.000 claims description 6
- 238000010884 ion-beam technique Methods 0.000 claims description 4
- 230000035515 penetration Effects 0.000 claims description 3
- 230000002285 radioactive effect Effects 0.000 claims description 2
- 238000001228 spectrum Methods 0.000 abstract description 4
- 150000001793 charged compounds Chemical class 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002575 chemical warfare agent Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
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- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
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- 238000004088 simulation Methods 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/061—Ion deflecting means, e.g. ion gates
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/065—Ion guides having stacked electrodes, e.g. ring stack, plate stack
- H01J49/066—Ion funnels
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Abstract
The invention provides a reflection type ion mobility spectrometer which comprises an ion mobility tube and a signal detection and processing unit, wherein the ion mobility tube comprises an ion storage area, an ion gate, a first mobility area, a first repulsion electrode, a second repulsion electrode, a metal mesh and a second mobility area, wherein the first mobility area and the second mobility area which are perpendicular or parallel to each other comprise funnel-shaped electrodes. When ions migrate to the tail end of the first migration zone, under the action of the repulsive electrodes of the first repulsive electrode and the second repulsive electrode, the movement speed of the ions is unchanged, the movement direction is deflected by 90 degrees or 180 degrees, the ions enter the second migration zone, continue to migrate in the second migration zone, and finally, the ions are detected and analyzed by the signal detection and processing unit, so that an ion migration spectrum of the detected object is obtained. By utilizing the reflection type ion mobility spectrometry technology, the migration path of ions can be doubled, and the resolution of the ion mobility spectrometry is improved; the migration electric field formed by the funnel-shaped electrodes in the two migration areas can inhibit radial diffusion of ions in the migration process, and the detection sensitivity of the instrument is improved.
Description
Technical Field
The invention belongs to the field of analytical instruments and detection, and particularly relates to a reflective ion mobility spectrometer.
Background
The ion mobility spectrometry is characterized by simple structure, high detection sensitivity, high response speed and the like, is widely applied to the on-site rapid detection of toxic dangerous goods such as explosives, drugs, chemical warfare agents and the like, and is counted to achieve hundreds of thousands of ion mobility spectrometry detection devices currently operated in the global airport, customs and the like. In addition to the public safety field, ion mobility spectrometry is also applied to other fields such as purity detection of foods, environmental contaminant detection, quality control in the pharmaceutical industry, biomarker search in patient expiration, and the like.
The resolution R of an ion mobility spectrum is one of the core parameters that measure its performance. The larger R, the greater the ability of the ion mobility spectrometry to separate and identify the species. The resolution R of ion migration can be expressed as (Analytical Chemistry,2008, 80, 6610) as:
wherein T is the gas temperature of the migration zone, q is the charge number of the ion band, V is the voltage between the ion gate and the ion receiver, T g The opening width of the ion gate is the migration time of the measured object. One way to increase the resolution R according to the above formula is to increase the migration time t of the test object. And because of
Therefore:
wherein L is the length of a migration zone of the migration tube, v is the migration speed of ions, K is the migration rate of an object to be detected, K is a constant value when the object to be detected is fixed, and E is the electric field intensity of the migration zone. When the gas temperature T and the ion gate width T of the migration zone are g When the electric field intensity E of the migration area is fixed, the longer the migration area L of the migration tube is, the longer the migration time t is, and the larger R of the single-charge detection object is. However, as the migration tube is lengthened, the ion migration path increases, the radial diffusion loss of ions also increases, and the number of ions reaching the detector decreases, thereby reducing the detection sensitivity of the instrument. Recently, waters of american instrumentation utilized the characteristic that ions at low pressure are easily bound by high frequency electric fields, and by means of ion cyclotron, the ion migration path was as long as 98cm, and the ion resolution in 2mbar nitrogen gas was as high as 750 (Analytical Chemistry,2019, 91, 8564), but this technique for improving ion mobility spectrometry resolution was not applicable at atmospheric pressure.
Under the atmospheric pressure environment, the improvement of the resolution of the ion mobility spectrometry is still one of hot spots and difficulties in the research of the ion mobility spectrometry technology under the condition of no loss or even improvement of detection sensitivity.
Disclosure of Invention
The technical problems to be solved by the invention are as follows: aiming at the technical requirements of improving the resolution of an ion mobility spectrometry by prolonging the migration path of ions under the atmospheric pressure, inhibiting the radial diffusion of the ions in the migration process and the like, a reflection type ion mobility spectrometer is provided, namely, under the atmospheric pressure, an ion migration tube is provided with two migration areas which are mutually vertical or parallel in space, after ions migrate a certain distance in a first migration area, the ion migration speed is unchanged under the action of a repulsive electrode, the movement direction deflects and enters the next migration area, and the ions continue to migrate in a uniform electric field, so that the migration path of the ions is prolonged, and the resolution of the ion mobility spectrometry is improved. In addition, in order to inhibit radial diffusion in the ion movement process, the electrode of the migration zone adopts a funnel structure so as to inhibit radial diffusion in the ion movement process, avoid ion loss caused by the lengthening of the migration path, improve the detection sensitivity of an ion migration spectrum and finally enhance the detection capability of the instrument.
The technical scheme adopted for solving the technical problems is as follows: a reflective ion mobility spectrometer, characterized by: the ion transfer tube comprises an ion storage area, an ion gate, a first transfer area, a first repulsion electrode, a second repulsion electrode, a metal mesh and a second transfer area, wherein the first transfer area and the second transfer area both comprise funnel-shaped electrodes; an ion gate is arranged between the ion storage area and the first migration area, and ions generated by a molecule-ion reaction or electrospray ionization means are stored in the ion storage area under the action of the ion gate; the tail end of the first migration zone is communicated with the second migration zone, and a metal net is arranged in the middle of the first migration zone; a signal detection and processing unit is arranged outside the outlet at the tail end of the second migration zone; when the ion gate is opened, the ion beam group enters the first migration zone and migrates to the downstream of the first migration zone under the action of an electric field E; when the ions reach the tail end of the first migration zone, the first repulsion electrode generates a repulsion electric field in the radial direction of the first migration zone, so that the movement direction of the ions is deflected and enters the second migration zone through the metal net, and the space position of the second migration zone is set to be perpendicular to or parallel to the first migration zone;
when the second migration zone and the first migration zone are arranged vertically, the first repulsion electrode is arranged at the tail end of the first migration zone, and the repulsion direction is along the radial direction of the first migration zone; after the ions reach the tail end of the first migration zone, under the action of a repulsive electric field generated by the first repulsive electrode, the movement speed of the ions is kept unchanged, the movement direction is deflected by 90 degrees, the ions pass through the metal mesh to enter the second migration zone, and under the action of an electric field E of the migration electric field, the ions reach a signal detection and processing unit to carry out detection and analysis processing, so that an ion migration spectrogram of a detected object is obtained;
when the second migration zone and the first migration zone are arranged in parallel, the first repulsion electrode is arranged at the tail end of the first migration zone, and the repulsion direction is along the radial direction of the first migration zone; the second repulsion electrode is arranged at the top end of the second migration zone, and the repulsion direction is along the direction opposite to the ion movement of the first migration zone; after the ions reach the tail end of the first migration zone, under the action of a repulsive electric field generated by the first repulsive electrode, the movement direction of the ions deflects 90 degrees, the ions pass through the metal mesh to reach the center position of the second migration zone, then the second repulsive electrode at the top end of the second migration zone generates a repulsive electric field opposite to the electric field direction of the first migration zone, the ions are pushed into the second migration zone, so that the migration speed of the ions in the second migration zone is consistent with the migration speed of the ions in the first migration zone, the movement direction of the ions deflects 180 degrees, and the ions reach the signal detection and processing unit under the action of the electric field E of the second migration zone to carry out detection and analysis processing, and the ion migration spectrogram of the detected object is obtained.
Furthermore, the ion migration tube comprises a first migration zone and a second migration zone which are perpendicular or parallel to each other, the first migration zone and the second migration zone both comprise funnel-shaped electrodes, and an electric field formed by the electrodes can inhibit radial diffusion of ions in the migration process, so that the detection sensitivity of the instrument is improved.
Further, the ions in the ion storage region are generated by ion-molecule reactions, including by means of photoionization sources, radioactive ionization sources, corona discharge ionization sources, plasma ionization sources, and film-type ionization sources, or directly by electrospray ionization sources.
Further, the ion gate is of the Bradbury-Nielson type or of the Tyndall-Powell type.
Further, when ions migrate to the end of the first migration zone, a repulsive electric field is generated in the radial direction of the first migration zone under the action of the first repulsive electrode, so that the movement direction of the ions is deflected, and the ions enter the second migration zone through the metal mesh.
Further, the metal mesh between the first migration zone and the second migration zone has the functions of: ions deflected in the direction of movement are caused to pass from the first migration zone into the second migration zone and penetration of the electric field between the first migration zone and the second migration zone is prevented.
Further, when the second migration area is perpendicular to the first migration area, after the ions reach the end of the first migration area, under the action of a repulsive electric field generated by the first repulsive electrode, the movement speed of the ions is kept unchanged, the movement direction is deflected by 90 degrees, the ions pass through the metal mesh to enter the second migration area, and under the action of a migration electric field E of the second migration area, the ions are detected and analyzed by the signal detection and processing unit, so that an ion migration spectrogram of the detected object is obtained.
Further, when the second migration zone and the first migration zone are parallel, after the ions reach the tail end of the first migration zone, under the action of a repulsive electric field generated by the first repulsive electrode, the movement direction of the ions deflects 90 degrees, passes through the metal mesh and reaches the center position of the second migration zone, then, the second repulsive electrode at the top end of the second migration zone generates a repulsive electric field opposite to the electric field direction of the first migration zone, and pushes the ions into the second migration zone, so that the migration speed of the ions in the second migration zone is consistent with the migration speed of the ions in the first migration zone, the movement direction deflects 180 degrees, and the ions reach the signal detection and processing unit under the action of the electric field E of the second migration zone, so as to carry out detection and analysis processing, and obtain an ion migration spectrogram of the detected object.
Furthermore, by utilizing the reflection type ion mobility spectrometry technology, the migration path of ions can be doubled, and the resolution of the ion mobility spectrometry can be improved; meanwhile, the migration electric field formed by the funnel-shaped electrode in the migration area can inhibit radial diffusion of ions in the migration process, and the detection sensitivity of the ion mobility spectrometry is improved.
Compared with the prior art, the invention has the advantages that:
(1) The invention deflects the movement direction of the ions in the migration process, so that the ions migrate in two ion migration areas which are perpendicular or parallel to each other, the migration path of the ions is increased, the migration path of the ions can be doubled by more than one time, and the resolution of ion migration spectrum is improved.
(2) In the invention, the constraint electric field formed by the funnel-shaped electrode of the ion migration zone can inhibit radial diffusion of ions and improve the detection sensitivity of the instrument.
Drawings
FIG. 1 is a schematic diagram of a reflective ion mobility spectrometer with a first mobility zone and a second mobility zone perpendicular to each other;
FIG. 2 is a schematic diagram of a reflective ion mobility spectrometer with a first mobility zone and a second mobility zone parallel to each other;
fig. 3 is a simulated view of the formation of a funnel-shaped electric field in an ion transfer region.
The reference numerals in the drawings mean: 1 is an ion migration tube, 2 is a signal detection and processing unit, 3 is an ion storage area, 4 is an ion gate, 5 is a first migration area, 6-1 is a first repulsion electrode, 6-2 is a second repulsion electrode, 7 is a metal mesh, 8 is a second migration area, and 9 is a funnel-shaped electrode.
Detailed Description
The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, but not all embodiments, and all other embodiments obtained by those skilled in the art without the inventive effort based on the embodiments of the present invention are within the scope of protection of the present invention.
As shown in fig. 1, the difference between a reflective ion mobility spectrometer designed by the present invention and a conventional ion mobility spectrometer is that: the ion transfer tube 1 comprises two transfer areas with mutually perpendicular or parallel spaces, when ions are transferred to the tail end of the first transfer area 5, the movement speed of the ions is unchanged under the action of the first repulsive electrode 6-1, the movement direction is deflected, and the ions enter the second transfer area 8 to continue to transfer.
As shown in fig. 1, according to embodiment 1 of the present invention, a first transfer region 5 and a second transfer region 8 are spatially perpendicular to each other, and such a reflection type ion transfer spectrometer comprises an ion transfer tube 1 and a signal detection and processing unit 2, wherein the ion transfer tube 1 comprises an ion storage region 3, an ion gate 4, the first transfer region 5, a first repulsive electrode 6-1, a metallic mesh 7 and the second transfer region 8, wherein the first transfer region 5 and the second transfer region 8 each comprise a funnel-shaped electrode 9. An ion gate 4 is arranged between the ion storage area 3 and the first migration area 5; the first repulsion electrode 6-1 is arranged at the tail end of the first migration zone 5, and the repulsion direction is along the radial direction of the first migration zone; ions generated by means of molecular-ion reaction or electrospray ionization are stored in the ion storage area 3 under the action of the ion gate 4, when the ion gate 4 is opened, the ion beam group enters the first migration area 5 and migrates downstream of the first migration area under the action of the electric field E. The tail end of the first migration zone 5 is communicated with the second migration zone 8, and a metal net 7 is arranged in the middle; a signal detection and processing unit 2 is arranged outside the outlet at the tail end of the second migration zone 8; when the ions reach the end of the first migration zone 5, the first repulsion electrode 6-1 generates a repulsion electric field in the radial direction, so that the movement speed of the ions is unchanged, the movement direction is deflected by 90 degrees, the ions enter the second migration zone 8 through the metal mesh 7, and reach the signal detection and processing unit 2 under the action of the migration electric field E of the second migration zone 8, and an ion migration spectrogram of the detected object is obtained.
As shown in fig. 2, according to embodiment 2 of the present invention, a first transfer region 5 and a second transfer region 8 are spatially parallel to each other, and such a reflection type ion transfer spectrometer includes an ion transfer tube 1 and a signal detection and processing unit 2, wherein the ion transfer tube 1 includes a first transfer region 3, an ion gate 4, a first transfer region 5, a first repulsion electrode 6-1, a second repulsion electrode 6-2, a metal mesh 7, and a second transfer region 8, wherein the first transfer region 5 and the second transfer region 8 each include a funnel-shaped electrode 9. An ion gate 4 is arranged between the ion storage area 3 and the first migration area 5; the first repulsion electrode 6-1 is arranged at the tail end of the first migration zone 5, and the repulsion direction is along the radial direction of the first migration zone; the second repulsive electrode 6-2 is arranged at the top end of the second migration zone 8, and the repulsive force direction is along the direction opposite to the ion movement of the first migration zone 5; ions generated by means of molecular-ion reaction or electrospray ionization are stored in the ion storage area 3 under the action of an ion gate, when the ion gate 4 is opened, an ion beam group enters the first migration area 5 and migrates downstream of the first migration area under the action of an electric field E. When the ions reach the tail end of the first migration zone 5, under the action of a repulsive electric field generated by the first repulsive electrode 6-1, the movement direction of the ions deflects 90 degrees, passes through the metal mesh 7 to reach the center position of the second migration zone 8, then the second repulsive electrode 6-2 at the top end of the second migration zone 8 generates a repulsive electric field opposite to the electric field of the first migration zone 5, the ions are pushed into the second migration zone 8, so that the migration speed of the ions in the second migration zone 8 is consistent with the migration speed of the ions in the first migration zone 5, the movement direction deflects 180 degrees, and the ions reach the signal detection and processing unit 2 under the action of the electric field E of the second migration zone 8 to carry out detection and analysis processing, and an ion migration spectrogram of a detected object is obtained.
Wherein the metal mesh between the first migration zone 5 and the second migration zone 8 has the function of: ions deflected in the direction of movement enter the second transfer zone 8 from the first transfer zone 5 and prevent penetration of the electric field between the first transfer zone and the second transfer zone 8.
Compared with the traditional single migration zone ion mobility spectrometer, the invention has two migration zones, the migration path of which is twice that of the traditional migration tube, and the formula is adoptedIt is known that the longer the migration path of a singly charged ion, the higher the resolution of the instrument when the temperature of the migration tube, the width of the ion gate and the migration electric field are set.
In addition, as can be seen from the electric field simulation result of fig. 3, the electric field intensity formed by the funnel-shaped electrode 9 in the migration region is sequentially weakened from the edge of the migration tube to the center of the migration tube, and under the action of the electric field, the radial diffusion of ions is effectively inhibited, so that the radial diffusion loss in the ion migration process is avoided, and the detection sensitivity of the instrument is improved.
Also, since the funnel-shaped electrodes 9 in the two migration areas form the electric field intensity which is sequentially weakened from the edge of the migration tube to the center of the migration tube as shown in fig. 3 in the migration areas, the diffusion of ions in the radial direction is suppressed, thereby improving the detection sensitivity of the instrument.
The above examples are for the purpose of describing the present invention only and are not intended to limit the scope of the present invention. The scope of the invention is defined by the appended claims. Various equivalents and modifications that do not depart from the spirit and principles of the invention are intended to be included within the scope of the invention.
Portions of this specification, not specifically described herein, are well known in the art.
Claims (9)
1. A reflective ion mobility spectrometer, characterized by: the ion transfer tube comprises an ion storage area, an ion gate, a first transfer area, a first repulsion electrode, a second repulsion electrode, a metal mesh and a second transfer area, wherein the first transfer area and the second transfer area both comprise funnel-shaped electrodes; an ion gate is arranged between the ion storage area and the first migration area, and ions generated by a molecule-ion reaction or electrospray ionization means are stored in the ion storage area under the action of the ion gate; the tail end of the first migration zone is communicated with the second migration zone, and a metal net is arranged in the middle of the first migration zone; a signal detection and processing unit is arranged outside the outlet at the tail end of the second migration zone; when the ion gate is opened, the ion beam group enters the first migration zone and migrates to the downstream of the first migration zone under the action of an electric field E; when the ions reach the tail end of the first migration zone, the first repulsion electrode generates a repulsion electric field in the radial direction of the ion migration tube, so that the movement direction of the ions deflects and enters the second migration zone through the metal net, and the space position of the second migration zone is set to be perpendicular to or parallel to the first migration zone;
when the second migration zone and the first migration zone are arranged vertically, the first repulsion electrode is arranged at the tail end of the first migration zone, and the repulsion direction is along the radial direction of the first migration zone; after the ions reach the tail end of the first migration zone, under the action of a repulsive electric field generated by the first repulsive electrode, the movement speed of the ions is kept unchanged, the movement direction is deflected by 90 degrees, the ions pass through the metal mesh to enter the second migration zone, and under the action of an electric field E of the migration electric field, the ions reach a signal detection and processing unit to carry out detection and analysis processing, so that an ion migration spectrogram of a detected object is obtained;
when the second migration zone and the first migration zone are arranged in parallel, the first repulsion electrode is arranged at the tail end of the first migration zone, and the repulsion direction is along the radial direction of the first migration zone; the second repulsion electrode is arranged at the top end of the second migration zone, and the repulsion direction is along the direction opposite to the ion movement of the first migration zone; after the ions reach the tail end of the first migration zone, under the action of a repulsive electric field generated by the first repulsive electrode, the movement direction of the ions deflects 90 degrees, the ions pass through the metal mesh to reach the center position of the second migration zone, then the second repulsive electrode at the top end of the second migration zone generates a repulsive electric field opposite to the electric field direction of the first migration zone, the ions are pushed into the second migration zone, so that the migration speed of the ions in the second migration zone is consistent with the migration speed of the ions in the first migration zone, the movement direction of the ions deflects 180 degrees, and the ions reach the signal detection and processing unit under the action of the electric field E of the second migration zone to carry out detection and analysis processing, and the ion migration spectrogram of the detected object is obtained.
2. The reflectometer as in claim 1 wherein: the ion migration tube comprises a first migration zone and a second migration zone which are perpendicular or parallel to each other, the first migration zone and the second migration zone both comprise funnel-shaped electrodes, and an electric field formed by the electrodes can inhibit radial diffusion of ions in the migration process, so that the detection sensitivity of the instrument is improved.
3. The reflectometer as in claim 1 wherein: the ions in the ion storage area are generated by ion-molecule reaction, including by utilizing a photoionization source, a radioactive ionization source, a corona discharge ionization source, a plasma ionization source and a film type ionization source, or are directly generated by an electrospray ionization source.
4. The reflectometer as in claim 1 wherein: the ion gate is of the Bradbury-Nielson type or of the Tyndall-Powell type.
5. The reflectometer as in claim 1 wherein: when ions migrate to the tail end of the first migration zone, a repulsive electric field is generated in the radial direction of the first migration zone under the action of the first repulsive electrode, so that the movement direction of the ions is deflected, and the ions enter the second migration zone through the metal net.
6. The reflectometer as in claim 1 wherein: a metal mesh between the first migration zone and the second migration zone, which functions as: ions deflected in the direction of movement are caused to pass from the first migration zone into the second migration zone and penetration of the electric field between the first migration zone and the second migration zone is prevented.
7. The reflectometer as in claim 1 wherein: when the second migration area is perpendicular to the first migration area, after the ions reach the tail end of the first migration area, under the action of a repulsive electric field generated by the first repulsive electrode, the movement speed of the ions is kept unchanged, the movement direction is deflected by 90 degrees, the ions pass through the metal mesh to enter the second migration area, and under the action of a migration electric field E of the second migration area, the ions are detected and analyzed by the signal detection and processing unit, so that an ion migration spectrogram of a detected object is obtained.
8. The reflectometer as in claim 1 wherein: when the second migration zone and the first migration zone are parallel, after the ions reach the tail end of the first migration zone, under the action of a repulsive electric field generated by the first repulsive electrode, the movement direction of the ions deflects 90 degrees, passes through the metal mesh and reaches the center position of the second migration zone, then, the second repulsive electrode at the top end of the second migration zone generates a repulsive electric field opposite to the electric field direction of the first migration zone, and pushes the ions into the second migration zone, so that the migration speed of the ions in the second migration zone is consistent with the migration speed of the ions in the first migration zone, the movement direction deflects 180 degrees, and the ions reach a signal detection and processing unit under the action of the electric field E of the second migration zone to carry out detection and analysis processing, thereby obtaining an ion migration spectrogram of a detected object.
9. The reflectometer as in claim 1 wherein: by utilizing the reflection type ion mobility spectrometry technology, the migration path of ions can be doubled, and the resolution of the ion mobility spectrometry can be improved; meanwhile, the migration electric field formed by the funnel-shaped electrode in the migration area can inhibit radial diffusion of ions in the migration process, and the detection sensitivity of the ion mobility spectrometry is improved.
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| CN214099579U (en) * | 2020-12-18 | 2021-08-31 | 中国科学院合肥物质科学研究院 | Reflection type ion mobility spectrometer |
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| CN102479663A (en) * | 2010-11-30 | 2012-05-30 | 中国科学院大连化学物理研究所 | Ion mobility tube and applications thereof |
| WO2014029378A1 (en) * | 2012-08-21 | 2014-02-27 | Eads Deutschland Gmbh | Ion mobility spectrometer for detecting analytes |
| CN111223751A (en) * | 2018-11-27 | 2020-06-02 | 中国科学院大连化学物理研究所 | Ion mobility spectrometry-time of flight mass spectrometer |
| CN214099579U (en) * | 2020-12-18 | 2021-08-31 | 中国科学院合肥物质科学研究院 | Reflection type ion mobility spectrometer |
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