CN112618790A - Brain surgery artificial skull repairing material and manufacturing method thereof - Google Patents

Brain surgery artificial skull repairing material and manufacturing method thereof Download PDF

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Publication number
CN112618790A
CN112618790A CN202110061948.8A CN202110061948A CN112618790A CN 112618790 A CN112618790 A CN 112618790A CN 202110061948 A CN202110061948 A CN 202110061948A CN 112618790 A CN112618790 A CN 112618790A
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parts
rubber sheet
silicon rubber
repairing material
layer
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蒋文庆
包卿
蒋蔚
金鹏
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Changzhou Wujin Peoples Hospital
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Changzhou Wujin Peoples Hospital
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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Abstract

The invention relates to the technical field of medical repair materials, in particular to an artificial skull repair material for brain surgery and a manufacturing method thereof, wherein the repair material comprises the following raw materials in parts by mass: 10-20 parts of silicon rubber sheet, 15-19 parts of polyether ether ketone resin, 13-15 parts of hydroxyapatite powder, 12-15 parts of reinforcing fiber, 8-10 parts of bone glue, 8-12 parts of modified tear-resistant resin and 8-10 parts of antibacterial additive, and the manufacturing method comprises the following steps: s1, mixing the modified tear-resistant resin and the antibacterial additive, adding bone glue, and continuously stirring uniformly to form sol; s2, placing the silicon rubber sheet in a mould, and then uniformly spraying a layer of hydroxyapatite powder on the surface of the silicon rubber sheet to obtain a silicon rubber sheet A; s3, paving a layer of reinforcing fiber on the surface of the silicon rubber sheet A, coating a layer of polyether-ether-ketone resin, and coating a layer of sol in S1 on the uppermost surface. The invention not only can improve the tear resistance of the repair material, but also can improve the antibacterial ability of the repair material after the skull is repaired.

Description

Brain surgery artificial skull repairing material and manufacturing method thereof
Technical Field
The invention relates to the technical field of medical repair materials, in particular to an artificial skull repair material for brain surgery and a manufacturing method thereof.
Background
Cranioplasty is a common operation in brain surgery for repairing skull defects caused by brain trauma, craniotomy and the like. The skull repairing operation mainly solves the problems that a defect area does not have effective protection on brain tissues, blood supply obstruction, abnormal cerebrospinal fluid circulation and the like, and also needs to solve the problems of shape repairing and reshaping. At present, skull repair surgery usually adopts autologous skull flap skull repair, metal substitute repair and CT three-dimensional. But is a key issue for the repair surgery as to what repair material is used.
The following repair materials are available: organic glass, bone cement, a silicon rubber sheet, autologous bones and a titanium net, wherein the silicon rubber sheet is poor in self tear resistance, so that a tear phenomenon can occur during skull suture, and inflammation infection can easily occur at the suture position, so that the brain surgery artificial skull repairing material and the manufacturing method thereof are provided for solving the problems.
Disclosure of Invention
The invention aims to solve the defects in the prior art, and provides an artificial skull repairing material for brain surgery and a manufacturing method thereof.
The brain surgery artificial skull repairing material comprises the following raw materials in parts by mass: 10-20 parts of silicon rubber sheet, 15-19 parts of polyether ether ketone resin, 13-15 parts of hydroxyapatite powder, 12-15 parts of reinforcing fiber, 8-10 parts of bone glue, 8-12 parts of modified tear-resistant resin and 8-10 parts of antibacterial additive.
Preferably, the reinforcing fiber is a mixed fiber of glass fiber and carbon fiber, and the mixing mass ratio of the glass fiber to the carbon fiber is 1: 1.
Preferably, the modified tear-resistant resin is prepared from HN807 resin serving as a raw material, polybutadiene serving as an additive and maleic anhydride serving as a compatilizer.
Preferably, the preparation process of the modified tear-resistant resin comprises the following steps: mixing HN807 resin and polybutadiene, adding maleic anhydride, mixing and stirring until the materials are completely fused, and then heating the mixture in water bath at the temperature of 80 ℃ for 15min to obtain the modified tear-resistant resin.
Preferably, the antibacterial additive is prepared from antibacterial peptide, chitin fiber and sorbic acid as raw materials, and the antibacterial peptide is bacterial antibacterial peptide.
Preferably, the preparation process of the antibacterial additive comprises the following steps: drying and crushing the antibacterial peptide, the chitin fiber and sorbic acid, extracting for 4 days at normal temperature by using 95% alcohol to obtain an extracting solution, centrifuging the extracting solution, distilling at 50 ℃ under reduced pressure, evaporating the alcohol in the extracting solution, and then fixing the volume to 1g/mL by using distilled water to obtain the antibacterial additive.
The manufacturing method of the brain surgery artificial skull repairing material comprises the following steps:
s1, mixing the modified tear-resistant resin and the antibacterial additive, adding bone glue, and continuously stirring uniformly to form sol;
s2, placing the silicon rubber sheet in a mould, and then uniformly spraying a layer of hydroxyapatite powder on the surface of the silicon rubber sheet to obtain a silicon rubber sheet A;
s3, paving a layer of reinforcing fiber on the surface of the silicon rubber sheet A, coating a layer of polyether-ether-ketone resin, coating a layer of sol in the S1 on the uppermost surface, and repeatedly coating until the thickness reaches 2-3mm to obtain a silicon rubber sheet B;
s4, spraying a layer of hydroxyapatite powder on the surface of the silicon rubber sheet B again to obtain a silicon rubber sheet C;
s5, curing the silicon rubber sheet C for 6-8 hours, demolding, and cooling to room temperature to obtain a semi-finished product;
and S6, placing the semi-finished product into a metal mold, curing for 2-3 hours at 100-150 ℃, cooling to 75-80 ℃, taking out from the mold, and punching, trimming, cleaning and drying to obtain the skull repairing material.
Preferably, the curing process in S5 is as follows: pre-curing at 40 deg.c for 4-5 hr, and then curing at 80-90 deg.c for 2-3 hr.
Preferably, the temperature of the S6 during die filling is 60-80 ℃.
The invention has the beneficial effects that:
1. according to the invention, HN807 resin is used as a raw material, polybutadiene is used as an additive, and maleic anhydride is used as a compatilizer to prepare the modified tear-resistant resin, so that the tear resistance of the repairing material can be effectively improved, and the effect of repairing the skull is improved.
2. The invention compounds the antibacterial peptide, the chitin fiber and the sorbic acid into the antibacterial additive by drying, crushing, extracting, distilling and the like, and can effectively improve the antibacterial capability of the repair material, thereby reducing the infection rate of the wound after the skull is repaired.
In conclusion, the tear resistance of the repair material can be improved, and the antibacterial ability of the repair material after the skull is repaired can also be improved.
Detailed Description
The present invention will be further illustrated with reference to the following specific examples.
The brain surgery artificial skull repairing material comprises the following raw materials in parts by mass: 10-20 parts of silicon rubber sheet, 15-19 parts of polyether ether ketone resin, 13-15 parts of hydroxyapatite powder, 12-15 parts of reinforcing fiber, 8-10 parts of bone glue, 8-12 parts of modified tear-resistant resin and 8-10 parts of antibacterial additive.
Wherein the reinforcing fiber is a mixed fiber of glass fiber and carbon fiber, and the mixing mass ratio of the glass fiber to the carbon fiber is 1: 1;
the modified tear-resistant resin is prepared from HN807 resin as a raw material, polybutadiene as an additive and maleic anhydride as a compatilizer, and the preparation process of the modified tear-resistant resin comprises the following steps: mixing HN807 resin and polybutadiene, adding maleic anhydride, mixing and stirring until the materials are completely fused, and then heating the materials in water bath at the temperature of 80 ℃ for 15min to obtain modified tear-resistant resin;
the antibacterial additive is prepared by taking antibacterial peptide, chitin fiber and sorbic acid as raw materials, wherein the antibacterial peptide is bacterial antibacterial peptide, and the preparation process of the antibacterial additive is as follows: drying and crushing the antibacterial peptide, the chitin fiber and sorbic acid, extracting for 4 days at normal temperature by using 95% alcohol to obtain an extracting solution, centrifuging the extracting solution, distilling at 50 ℃ under reduced pressure, evaporating the alcohol in the extracting solution, and then fixing the volume to 1g/mL by using distilled water to obtain the antibacterial additive.
The manufacturing method of the brain surgery artificial skull repairing material comprises the following steps:
s1, mixing the modified tear-resistant resin and the antibacterial additive, adding bone glue, and continuously stirring uniformly to form sol;
s2, placing the silicon rubber sheet in a mould, and then uniformly spraying a layer of hydroxyapatite powder on the surface of the silicon rubber sheet to obtain a silicon rubber sheet A;
s3, paving a layer of reinforcing fiber on the surface of the silicon rubber sheet A, coating a layer of polyether-ether-ketone resin, coating a layer of sol in the S1 on the uppermost surface, and repeatedly coating until the thickness reaches 3mm to obtain a silicon rubber sheet B;
s4, spraying a layer of hydroxyapatite powder on the surface of the silicon rubber sheet B again to obtain a silicon rubber sheet C;
s5, pre-curing the silicone rubber sheet C at 40 ℃ for 4 hours, curing at 85 ℃ for 2 hours, demolding, and cooling to room temperature to obtain a semi-finished product;
and S6, placing the semi-finished product into a metal mold at the temperature of 70 ℃, solidifying for 2 hours at the temperature of 120 ℃, cooling to 75 ℃, taking out the semi-finished product from the mold, and punching, trimming, cleaning and drying to obtain the skull repairing material.
The first embodiment is as follows:
the brain surgery artificial skull repairing material comprises the following raw materials in parts by mass: 10 parts of silicon rubber sheet, 15 parts of polyether-ether-ketone resin, 13 parts of hydroxyapatite powder, 12 parts of reinforcing fiber, 8 parts of bone glue, 8 parts of modified tear-resistant resin and 8 parts of antibacterial additive.
Example two:
the brain surgery artificial skull repairing material comprises the following raw materials in parts by mass: 15 parts of silicon rubber sheet, 17 parts of polyether-ether-ketone resin, 14 parts of hydroxyapatite powder, 13 parts of reinforcing fiber, 9 parts of bone glue, 10 parts of modified tear-resistant resin and 9 parts of antibacterial additive.
Example three:
the brain surgery artificial skull repairing material comprises the following raw materials in parts by mass: 20 parts of silicon rubber sheet, 19 parts of polyether-ether-ketone resin, 15 parts of hydroxyapatite powder, 15 parts of reinforcing fiber, 10 parts of bone glue, 12 parts of modified tear-resistant resin and 10 parts of antibacterial additive.
The first to third embodiments above each produce a skull repair material by the following steps:
s1, mixing the modified tear-resistant resin and the antibacterial additive, adding bone glue, and continuously stirring uniformly to form sol;
s2, placing the silicon rubber sheet in a mould, and then uniformly spraying a layer of hydroxyapatite powder on the surface of the silicon rubber sheet to obtain a silicon rubber sheet A;
s3, paving a layer of reinforcing fiber on the surface of the silicon rubber sheet A, coating a layer of polyether-ether-ketone resin, coating a layer of sol in the S1 on the uppermost surface, and repeatedly coating until the thickness reaches 3mm to obtain a silicon rubber sheet B;
s4, spraying a layer of hydroxyapatite powder on the surface of the silicon rubber sheet B again to obtain a silicon rubber sheet C;
s5, pre-curing the silicone rubber sheet C at 40 ℃ for 4 hours, curing at 85 ℃ for 2 hours, demolding, and cooling to room temperature to obtain a semi-finished product;
and S6, placing the semi-finished product into a metal mold at the temperature of 70 ℃, solidifying for 2 hours at the temperature of 120 ℃, cooling to 75 ℃, taking out the semi-finished product from the mold, and punching, trimming, cleaning and drying to obtain the skull repairing material.
Test one: measurement of tear resistance of the skull repairing Material
Comparative example one:
the brain surgery artificial skull repairing material comprises the following raw materials in parts by mass: 10 parts of silicon rubber sheet, 15 parts of polyether-ether-ketone resin, 13 parts of hydroxyapatite powder, 12 parts of reinforcing fiber, 8 parts of bone glue and 8 parts of antibacterial additive.
Comparative example two:
the brain surgery artificial skull repairing material comprises the following raw materials in parts by mass: 15 parts of silicon rubber sheet, 17 parts of polyether-ether-ketone resin, 14 parts of hydroxyapatite powder, 13 parts of reinforcing fiber, 9 parts of bone glue and 9 parts of antibacterial additive.
Comparative example three:
the brain surgery artificial skull repairing material comprises the following raw materials in parts by mass: 20 parts of silicon rubber sheet, 19 parts of polyether-ether-ketone resin, 15 parts of hydroxyapatite powder, 15 parts of reinforcing fiber, 10 parts of bone glue and 10 parts of antibacterial additive.
The first comparative example to the third comparative example were each manufactured by the following steps:
s1, mixing the antibacterial additive with the bone glue, and continuously stirring uniformly until sol is formed;
s2, placing the silicon rubber sheet in a mould, and then uniformly spraying a layer of hydroxyapatite powder on the surface of the silicon rubber sheet to obtain a silicon rubber sheet A;
s3, paving a layer of reinforcing fiber on the surface of the silicon rubber sheet A, coating a layer of polyether-ether-ketone resin, coating a layer of sol in the S1 on the uppermost surface, and repeatedly coating until the thickness reaches 3mm to obtain a silicon rubber sheet B;
s4, spraying a layer of hydroxyapatite powder on the surface of the silicon rubber sheet B again to obtain a silicon rubber sheet C;
s5, pre-curing the silicone rubber sheet C at 40 ℃ for 4 hours, curing at 85 ℃ for 2 hours, demolding, and cooling to room temperature to obtain a semi-finished product;
and S6, placing the semi-finished product into a metal mold at the temperature of 70 ℃, solidifying for 2 hours at the temperature of 120 ℃, cooling to 75 ℃, taking out the semi-finished product from the mold, and punching, trimming, cleaning and drying to obtain the skull repairing material.
Reference example one:
the brain surgery artificial skull repairing material comprises the following raw materials in parts by mass: 10 parts of silicon rubber sheet, 15 parts of polyether-ether-ketone resin, 13 parts of hydroxyapatite powder, 12 parts of reinforcing fiber, 8 parts of bone glue, 8 parts of tear-resistant resin and 8 parts of antibacterial additive.
Reference example two:
the brain surgery artificial skull repairing material comprises the following raw materials in parts by mass: 15 parts of silicon rubber sheet, 17 parts of polyether-ether-ketone resin, 14 parts of hydroxyapatite powder, 13 parts of reinforcing fiber, 9 parts of bone glue, 10 parts of tear-resistant resin and 9 parts of antibacterial additive.
Reference example three:
the brain surgery artificial skull repairing material comprises the following raw materials in parts by mass: 20 parts of silicon rubber sheet, 19 parts of polyether-ether-ketone resin, 15 parts of hydroxyapatite powder, 15 parts of reinforcing fiber, 10 parts of bone glue, 12 parts of tear-resistant resin and 10 parts of antibacterial additive.
The tear-resistant resins in the first reference example to the third reference example are all HN807 resins, and the skull repairing material is manufactured by the following steps:
s1, mixing the tear-resistant resin and the antibacterial additive, adding bone glue, and continuously stirring uniformly to form sol;
s2, placing the silicon rubber sheet in a mould, and then uniformly spraying a layer of hydroxyapatite powder on the surface of the silicon rubber sheet to obtain a silicon rubber sheet A;
s3, paving a layer of reinforcing fiber on the surface of the silicon rubber sheet A, coating a layer of polyether-ether-ketone resin, coating a layer of sol in the S1 on the uppermost surface, and repeatedly coating until the thickness reaches 3mm to obtain a silicon rubber sheet B;
s4, spraying a layer of hydroxyapatite powder on the surface of the silicon rubber sheet B again to obtain a silicon rubber sheet C;
s5, pre-curing the silicone rubber sheet C at 40 ℃ for 4 hours, curing at 85 ℃ for 2 hours, demolding, and cooling to room temperature to obtain a semi-finished product;
and S6, placing the semi-finished product into a metal mold at the temperature of 70 ℃, solidifying for 2 hours at the temperature of 120 ℃, cooling to 75 ℃, taking out the semi-finished product from the mold, and punching, trimming, cleaning and drying to obtain the skull repairing material.
The skull repairing materials obtained in the above examples, comparative examples and reference examples were subjected to tear strength tests according to the test method specified in national Standard No. GB/T529-1999, and the tear strengths in the horizontal direction and in the vertical direction are shown in the following tables, respectively:
Figure DEST_PATH_IMAGE002
from the data in the table, whether the tear strength in the horizontal direction or the tear strength in the vertical direction, the advantages and disadvantages are that the example is greater than the reference example and greater than the comparative example, and the comparative example and the reference example can find that the modified tear-resistant resin can further improve the tear resistance of the repair material.
And (2) test II: measurement of antibacterial ability of the skull repairing Material
Comparative example four:
the brain surgery artificial skull repairing material comprises the following raw materials in parts by mass: 10 parts of silicon rubber sheet, 15 parts of polyether-ether-ketone resin, 13 parts of hydroxyapatite powder, 12 parts of reinforcing fiber, 8 parts of bone glue and 8 parts of modified tear-resistant resin.
Comparative example five:
the brain surgery artificial skull repairing material comprises the following raw materials in parts by mass: 15 parts of silicon rubber sheet, 17 parts of polyether-ether-ketone resin, 14 parts of hydroxyapatite powder, 13 parts of reinforcing fiber, 9 parts of bone glue and 10 parts of modified tear-resistant resin.
Comparative example six:
the brain surgery artificial skull repairing material comprises the following raw materials in parts by mass: 20 parts of silicon rubber sheet, 19 parts of polyether-ether-ketone resin, 15 parts of hydroxyapatite powder, 15 parts of reinforcing fiber, 10 parts of bone glue and 12 parts of modified tear-resistant resin.
Taking the first to third examples and the fourth to sixth comparative examples, performing antibacterial detection on the manufactured skull repairing materials, sewing two repairing materials prepared in the same example or the comparative example together, placing the repairing materials in a beaker, pouring SBF simulated body fluid (the SBF simulated body fluid mainly comprises sodium chloride, potassium chloride, dipotassium hydrogen phosphate, magnesium chloride, calcium chloride, Tris, sodium bicarbonate and the like, performing aseptic treatment, and having pH = 7.4) into the beaker until all the repairing materials are immersed, standing the repairing materials, observing the inflammation time of the sewing part, and recording the time length in the following table:
time/day of inflammation Time/day of inflammation Time/day of inflammation
Example one 7 Example two 6 EXAMPLE III 6
Comparative example No. four 2 Comparative example five 1 Comparative example six 2
As can be seen from the data in the above table, the time of inflammation at the seam of the repair material in the examples is later than that of the repair material in the comparative example, that is, the addition and use of the antibacterial additive can alleviate the infection rate at the wound.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims (9)

1. The brain surgery artificial skull repairing material is characterized by comprising the following raw materials in parts by mass: 10-20 parts of silicon rubber sheet, 15-19 parts of polyether ether ketone resin, 13-15 parts of hydroxyapatite powder, 12-15 parts of reinforcing fiber, 8-10 parts of bone glue, 8-12 parts of modified tear-resistant resin and 8-10 parts of antibacterial additive.
2. The brain surgery artificial skull repairing material according to claim 1, wherein the reinforcing fiber is a mixed fiber of glass fiber and carbon fiber, and the mixing mass ratio of the glass fiber to the carbon fiber is 1: 1.
3. The cranial surgery artificial skull repairing material according to claim 1, wherein the modified tear-resistant resin is prepared from HN807 resin as a raw material, polybutadiene as an additive and maleic anhydride as a compatilizer.
4. The brain surgery artificial skull repairing material according to claim 3, wherein the modified tear-resistant resin is prepared by the following steps: mixing HN807 resin and polybutadiene, adding maleic anhydride, mixing and stirring until the materials are completely fused, and then heating the mixture in water bath at the temperature of 80 ℃ for 15min to obtain the modified tear-resistant resin.
5. The material for repairing the artificial skull in the brain surgery department according to claim 1, wherein the antibacterial additive is prepared by taking antibacterial peptide, chitin fiber and sorbic acid as raw materials, and the antibacterial peptide is bacterial antibacterial peptide.
6. The cranial surgery artificial skull repairing material according to claim 5, wherein the antibacterial additive is prepared by the following steps: drying and crushing the antibacterial peptide, the chitin fiber and sorbic acid, extracting for 4 days at normal temperature by using 95% alcohol to obtain an extracting solution, centrifuging the extracting solution, distilling at 50 ℃ under reduced pressure, evaporating the alcohol in the extracting solution, and then fixing the volume to 1g/mL by using distilled water to obtain the antibacterial additive.
7. The manufacturing method of the brain surgery artificial skull repairing material is characterized by comprising the following steps:
s1, mixing the modified tear-resistant resin and the antibacterial additive, adding bone glue, and continuously stirring uniformly to form sol;
s2, placing the silicon rubber sheet in a mould, and then uniformly spraying a layer of hydroxyapatite powder on the surface of the silicon rubber sheet to obtain a silicon rubber sheet A;
s3, paving a layer of reinforcing fiber on the surface of the silicon rubber sheet A, coating a layer of polyether-ether-ketone resin, coating a layer of sol in the S1 on the uppermost surface, and repeatedly coating until the thickness reaches 2-3mm to obtain a silicon rubber sheet B;
s4, spraying a layer of hydroxyapatite powder on the surface of the silicon rubber sheet B again to obtain a silicon rubber sheet C;
s5, curing the silicon rubber sheet C for 6-8 hours, demolding, and cooling to room temperature to obtain a semi-finished product;
and S6, placing the semi-finished product into a metal mold, curing for 2-3 hours at 100-150 ℃, cooling to 75-80 ℃, taking out from the mold, and punching, trimming, cleaning and drying to obtain the skull repairing material.
8. The method for manufacturing the cranial surgery artificial skull repairing material according to claim 7, wherein the curing process in the step S5 is as follows: pre-curing at 40 deg.c for 4-5 hr, and then curing at 80-90 deg.c for 2-3 hr.
9. The method for manufacturing the cranial prosthesis repairing material for brain surgery according to claim 7, wherein the temperature of the mold in S6 is 60-80 ℃.
CN202110061948.8A 2021-01-18 2021-01-18 Brain surgery artificial skull repairing material and manufacturing method thereof Pending CN112618790A (en)

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