CN112617825A - Application of lead electrode in rapid positioning of epileptic focus - Google Patents
Application of lead electrode in rapid positioning of epileptic focus Download PDFInfo
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- CN112617825A CN112617825A CN202011502647.6A CN202011502647A CN112617825A CN 112617825 A CN112617825 A CN 112617825A CN 202011502647 A CN202011502647 A CN 202011502647A CN 112617825 A CN112617825 A CN 112617825A
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- 230000001037 epileptic effect Effects 0.000 title claims abstract description 28
- 210000004556 brain Anatomy 0.000 claims abstract description 26
- 238000006243 chemical reaction Methods 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 10
- 230000003902 lesion Effects 0.000 claims description 6
- 238000005516 engineering process Methods 0.000 claims description 4
- 210000003128 head Anatomy 0.000 abstract description 12
- 102000001554 Hemoglobins Human genes 0.000 abstract description 8
- 108010054147 Hemoglobins Proteins 0.000 abstract description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 8
- 230000002490 cerebral effect Effects 0.000 abstract description 8
- 229910052760 oxygen Inorganic materials 0.000 abstract description 8
- 239000001301 oxygen Substances 0.000 abstract description 8
- 206010010904 Convulsion Diseases 0.000 abstract description 5
- 206010015037 epilepsy Diseases 0.000 abstract description 4
- 208000028329 epileptic seizure Diseases 0.000 abstract description 4
- 210000004761 scalp Anatomy 0.000 abstract description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 12
- 229910052742 iron Inorganic materials 0.000 description 6
- 238000012544 monitoring process Methods 0.000 description 4
- 208000001654 Drug Resistant Epilepsy Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
- A61B5/4094—Diagnosing or monitoring seizure diseases, e.g. epilepsy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
- A61B5/6803—Head-worn items, e.g. helmets, masks, headphones or goggles
Abstract
The invention discloses an application of a lead electrode in rapidly positioning an epileptic focus, which is used for acquiring epileptic electroencephalogram signals to determine the position of the epileptic focus, and specifically comprises the following steps: s10, arranging a plurality of lead electrodes on the brain of the patient; s20, continuously scanning the brain of the patient by using the lead electrodes; s30, acquiring epilepsia electroencephalogram signals by using the lead electrodes, and performing signal conversion; s40, determining the position of the epileptic focus according to the signal of the lead electrode; the method comprises the steps of continuously scanning the brain of a patient by utilizing near infrared rays, detecting the infrared rays scattered by the brain to different parts on the surface of the scalp through a diode, reflecting the mixed projection intensity of oxygenated hemoglobin and reduced hemoglobin in a closed state of the head through signal conversion, obtaining the local cerebral oxygen saturation through conversion, highly perfusing the local brain area during epileptic seizure, increasing the cerebral oxygen saturation and increasing the near infrared attenuation, and determining the position of a focus through the principle.
Description
Technical Field
The invention relates to the field of focus positioning and positioning devices, in particular to application of a lead electrode in rapid positioning of an epileptic focus.
Background
Recurrent attacks are an inherent feature of neurons of the brain due to abnormally excessive or synchronized activity, resulting in transient symptoms. The prevalence rate in China is 7 per thousand, and 900 ten thousand epileptic patients are estimated. The majority of patients can control the seizures by taking medicines, but 20-30% of patients have ineffective medicine control, which is called refractory epilepsy, and the surgical operation is an important means for treating the refractory epilepsy; the key to surgical treatment is lesion localization, i.e., finding out abnormally excited neuronal populations.
Disclosure of Invention
Aiming at the problems, the invention provides the application of the lead electrode in the rapid positioning of the epileptic focus, and has the advantage of accurately positioning the epileptic focus.
The technical scheme of the invention is as follows:
the application of a lead electrode in rapidly positioning an epileptic focus, which acquires epileptic brain electrical signals through the lead electrode to determine the position of the epileptic focus, specifically comprises the following steps:
s10, arranging a plurality of lead electrodes on the brain of the patient;
s20, continuously scanning the brain of the patient by using the lead electrodes;
s30, acquiring epilepsia electroencephalogram signals by using the lead electrodes, and performing signal conversion;
and S40, determining the position of the epileptic focus according to the signals of the lead electrodes.
The working principle of the technical scheme is as follows:
the method comprises the steps of continuously scanning the brain of a patient by utilizing near infrared rays, detecting the infrared rays scattered by the brain to different parts on the surface of the scalp through a diode, reflecting the mixed projection intensity of oxygenated hemoglobin and reduced hemoglobin in a closed state of the head through signal conversion, obtaining the local cerebral oxygen saturation through conversion, highly perfusing the local brain area during epileptic seizure, increasing the cerebral oxygen saturation and increasing the near infrared attenuation, and determining the position of a focus through the principle.
In a further aspect, in step S10, the lead electrode is non-invasive; each lead electrode emits near infrared rays with the wavelength of 0.76-400 mu m.
In a further technical solution, in step S10, in step S10, all the lead electrodes are uniformly distributed on a hemispherical head cover, and the number of the lead electrodes is not less than twenty.
In a further aspect, all of the lead electrodes are movably distributed on the headgear.
In a further technical solution, step S10 further includes the following steps:
s11, uniformly distributing all lead electrodes on the head cover;
step S20 further includes the steps of:
s21, performing distributed continuous scanning on the brain of the patient by using all lead electrodes;
s22, when the electrodes to be led detect the electric signals, moving all the lead electrodes to the area where the electric signals are located, and performing centralized continuous scanning;
in a further technical scheme, the method also comprises the following steps: s50, assisting in locating the epileptic focus position by combining FMRI and EEG technologies.
In a further embodiment, in step S50, after the lead electrodes monitor the location of the lesion, the location is confirmed and verified by FMRI and EEG techniques.
The invention has the beneficial effects that:
1. the method comprises the steps of continuously scanning the brain of a patient by utilizing near infrared rays, detecting the infrared rays scattered by the brain to different parts on the surface of the scalp through a diode, reflecting the mixed projection intensity of oxygenated hemoglobin and reduced hemoglobin in a closed state of the head through signal conversion, obtaining the local cerebral oxygen saturation through conversion, highly perfusing the local brain area during epileptic seizure, increasing the cerebral oxygen saturation, increasing the near infrared ray attenuation, and determining the position of a focus through the principle;
2. the movable lead electrodes are used for carrying out centralized monitoring after the position of a focus is preliminarily detected, so that the using quantity of the lead electrodes can be reduced, and the monitoring cost is reduced;
3. the FMRI and EEG techniques are used for verification, so that the accuracy of the lesion position can be improved, and the risk of subsequent operations is reduced.
Drawings
FIG. 1 is a schematic view of the construction of the hood of the present invention.
Description of reference numerals:
1. a head cover; 2. iron sheets; 3. and (4) pits.
Detailed Description
The embodiments of the present invention will be further described with reference to the accompanying drawings.
Example (b):
the application of the lead electrode in rapidly positioning the epileptic focus comprises the following steps:
s10, arranging a plurality of lead electrodes on the brain of the patient; the lead electrodes are non-invasive;
each lead electrode emits near infrared rays with the wavelength of 0.76-400 mu m;
s11, uniformly distributing all lead electrodes on the head cover;
all lead electrodes are uniformly distributed on a hemispherical head cover, and the number of the lead electrodes is not less than twenty; all lead electrodes are movably distributed on the head cover; the movable lead electrodes are used for carrying out centralized monitoring after the position of a focus is preliminarily detected, so that the using quantity of the lead electrodes can be reduced, and the monitoring cost is reduced.
S20, continuously scanning the brain of the patient by using the lead electrodes;
s21, performing distributed continuous scanning on the brain of the patient by using all lead electrodes;
s22, when the electrodes to be led detect the electric signals, moving all the lead electrodes to the area where the electric signals are located, and performing centralized continuous scanning;
s30, acquiring epilepsia electroencephalogram signals by using the lead electrodes, and performing signal conversion;
and S40, determining the position of the epileptic focus according to the signals of the lead electrodes.
The method comprises the steps of continuously scanning the brain of a patient by utilizing near infrared rays, detecting the infrared rays scattered by the brain to different parts on the surface of the scalp through a diode, reflecting the mixed projection intensity of oxygenated hemoglobin and reduced hemoglobin in a closed state of the head through signal conversion, obtaining the local cerebral oxygen saturation through conversion, highly perfusing the local brain area during epileptic seizure, increasing the cerebral oxygen saturation and increasing the near infrared attenuation, and determining the position of a focus through the principle.
In another embodiment:
further comprising the steps of: and S50, assisting in positioning the epileptic focus position by combining with FMRI and EEG technologies, and confirming and verifying through the FMRI and EEG technologies after the lead electrodes monitor the focus position. The FMRI and EEG techniques are used for verification, so that the accuracy of the lesion position can be improved, and the risk of subsequent operations is reduced.
In another embodiment:
as shown in fig. 1, the head cover 1 is hemispherical, a plurality of annular iron sheets 2 are arranged on the head cover 1, a plurality of circular pits 3 are arranged on each iron sheet 2, and a circular magnet is arranged on the back of each lead electrode. The position of all lead electrodes can be randomly arranged by utilizing the magnet to be adsorbed on the iron sheet 2.
In another embodiment:
each pit 3 of the iron sheet 2 on the hood 1 corresponds to one wire groove, the tail end of each wire groove is provided with a magnet, and the lead of each lead electrode is wrapped with an iron sheet; the leads of the lead electrodes can be distributed orderly through the wire grooves.
The above-mentioned embodiments only express the specific embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.
Claims (7)
1. The application of the lead electrode in rapidly positioning the epileptic focus is characterized in that the position of the epileptic focus is determined by acquiring epileptic brain electrical signals through the lead electrode, and the method specifically comprises the following steps:
s10, arranging a plurality of lead electrodes on the brain of the patient;
s20, continuously scanning the brain of the patient by using the lead electrodes;
s30, acquiring epilepsia electroencephalogram signals by using the lead electrodes, and performing signal conversion;
and S40, determining the position of the epileptic focus according to the signals of the lead electrodes.
2. The use of a lead electrode according to claim 1 for rapidly locating an epileptic lesion, wherein in step S10, the lead electrode is non-invasive; each lead electrode emits near infrared rays with the wavelength of 0.76-400 mu m.
3. The use of a lead electrode in rapidly locating epileptic focus according to claim 2, wherein in step S10, all the lead electrodes are uniformly distributed on a hemispherical head cover, and the number of the lead electrodes is not less than twenty.
4. Use of a lead electrode according to claim 3 for rapidly locating epileptic lesions, wherein all of the lead electrodes are movably distributed on the hood.
5. The use of a lead electrode according to claim 4, wherein step S10 further comprises the following steps:
s11, uniformly distributing all lead electrodes on the head cover;
step S20 further includes the steps of:
s21, performing distributed continuous scanning on the brain of the patient by using all lead electrodes;
and S22, when the electrodes to be led detect the electric signals, moving all the lead electrodes to the area where the electric signals are located, and performing centralized continuous scanning.
6. The use of a lead electrode according to claim 1 for rapidly locating an epileptic focus, further comprising the steps of: s50, assisting in locating the epileptic focus position by combining FMRI and EEG technologies.
7. The use of a lead electrode in rapidly locating epileptic foci as in claim 6, wherein in step S50, when the lead electrode monitors the location of the focus, it is confirmed and verified by FMRI and EEG techniques.
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| CN202011502647.6A CN112617825A (en) | 2020-12-17 | 2020-12-17 | Application of lead electrode in rapid positioning of epileptic focus |
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| CN202011502647.6A CN112617825A (en) | 2020-12-17 | 2020-12-17 | Application of lead electrode in rapid positioning of epileptic focus |
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| 毛青: "脑氧饱和度监测与脑氧供需失衡的早期发现", 《国外医学(脑血管疾病分册)》 * |
| 赵景旺,陈旨娟,杨卫东.: "难治性癫痫的致痫灶定位方法", 《中华临床医师杂志(电子版)》 * |
| 邓施平,陈琳: "癫痫定义与分类对癫痫诊断的影响", 《江西省第七次中西医结合神经科学术交流会论文集》 * |
| 钟华,张桁忠,吴健,马灿灿.: "血氧水平依赖的脑功能成像技术在癫痫的诊断和治疗中的应用进展", 《中国妇幼健康研究》 * |
| 陈丽敏,胡洋,姜晓晗,邢英琦.: "近红外光谱分析技术在神经科中的临床应用与新进展", 《中风与神经疾病杂志》 * |
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