CN112611878A - Control device for automatic sampler and automatic measurement system - Google Patents
Control device for automatic sampler and automatic measurement system Download PDFInfo
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/24—Automatic injection systems
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- G01N35/00732—Identification of carriers, materials or components in automatic analysers
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/0092—Scheduling
- G01N35/0095—Scheduling introducing urgent samples with priority, e.g. Short Turn Around Time Samples [STATS]
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8804—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 automated systems
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- G—PHYSICS
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- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N2035/00891—Displaying information to the operator
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
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Abstract
The invention provides a control device of an automatic sampler and an automatic measuring system, which can easily set and change the measuring state of a sample on the holding position information showing the actual sample holding position and can easily grasp the measuring state. A control device for an automatic sampler, which is used for the automatic sampler, has a control unit and a storage unit, and is provided with: a sample holding unit for holding a plurality of samples in an aligned manner; and a sample introduction unit that introduces the plurality of samples into the measurement device one by one, wherein the control unit causes a predetermined display unit to display holding position information indicating holding positions of the plurality of samples in the sample holding unit, and when one of a plurality of measurement situations indicating a measurement state of the predetermined sample is specified by a user on the holding position information, the control unit stores the specified position of the sample and the specified measurement situation in a storage unit in association with each other, and performs color discrimination display or highlight display on the sample in which the measurement situation is specified on the holding position information.
Description
Technical Field
The present invention relates to a control device for an autosampler provided in a measurement device such as a chromatography device, and an automatic measurement system including the control device.
Background
Conventionally, in the measurement of a liquid chromatography (HPLC) apparatus or the like, an autosampler has been used to automate the introduction of a sample into the apparatus. The automatic sampler includes: a sample holding unit such as a rack for holding a plurality of samples in an aligned manner; and a sample introduction unit that introduces a plurality of samples into the measurement device one by one. Here, for example, serial numbers are assigned as the order of introduction of samples from the sample holding portion.
Conventionally, in setting the measurement order (introduction order) of a sample by an auto-sampler, the position of the sample, the measurement conditions, and the like are input for each serial number of a sample holding unit in a reservation table on a device screen.
However, when the sample is input in the form of a table, the operation is complicated, and when the sample is input in the table, it is difficult to intuitively grasp the actual installation position where the sample is installed in the sample holding portion, and an input error is likely to occur.
Therefore, the following techniques were developed: the order of measurement of the samples, the measurement conditions, and the like can be set in a tabular form while checking the display screen by displaying the arrangement state of the samples on the sample holding unit (patent document 1).
Prior art documents
Patent document
Patent document 1: japanese patent No. 3394744
As shown in fig. 12, in the method described in patent document 1, a window of an analysis reservation input table 500 and a sample retention map 600 showing an actual sample arrangement (retention) state are displayed on a display screen. In this case, the sample at the position 2-2 (column 2, row 2) of the sample holder of sequence No. 1 is first measured, and the samples at the positions 1-1 (column 1, row 1) and 4-2 (column 4, row 2) of the sample holders of sequence Nos. 2 and 3 are measured in this order.
However, when the order of arrangement of the samples on the sample retention map 600 is different from the order of measurement of the samples based on the serial numbers, it is difficult to grasp at which position the next measurement sample is located, and there is a problem such as: before proceeding to the next measurement, the sample is replaced due to a defect, or it is difficult to change the sample such as inserting another sample in an emergency and performing the measurement.
In addition, even when the measurement procedure is changed, the position of the sample to be measured must be input first by returning to the analysis reservation input table 500, which is troublesome and prone to error.
In particular, in the case of blood tests in hospitals and the like, many unstable operations such as tests for emergency patients are performed, which is likely to cause the above-described problems, and if there is an error such as taking a wrong sample, it becomes a serious problem.
Disclosure of Invention
The present invention has been made to solve the above-described problems, and an object thereof is to provide a control device for an autosampler and an automatic measurement system including the control device, which can easily set and change a measurement state of a sample on holding position information showing an actual sample holding position, and can easily grasp the measurement state.
In order to achieve the above object, a control device for an autosampler according to the present invention is an autosampler including a sample holder for holding a plurality of samples in an aligned manner and a sample introduction unit for introducing the plurality of samples one by one to a measurement device, the control device including a control unit and a storage unit, wherein the control unit causes a predetermined display unit to display holding position information indicating holding positions of the plurality of samples in the sample holder, and when one of a plurality of measurement conditions indicating a measurement state of the predetermined sample is designated by a user in the holding position information, the control unit causes the storage unit to store the designated position of the sample and the measurement condition in association with each other, and, the control unit displays the sample to which the measurement condition is designated, in a color-differentiated or highlighted manner on the holding position information.
According to the control device of the automatic sampler, by selecting the samples on the holding position information showing the holding positions reflecting the actual order of arrangement (measurement order) of the respective samples, the measurement state of the respective samples can be easily set and changed visually in accordance with the order of arrangement of the samples.
Further, since the measurement state of each designated sample is displayed in a differentiated or highlighted manner by color, the order of arrangement of the samples and the measurement state of the samples can be visually and easily grasped.
As a result, the sample can be easily replaced before measurement, and insertion measurement of other samples and the like can be easily performed while observing the measurement state.
In the control device of an auto-sampler according to the present invention, when a measurement reservation state indicating a next measurement among the measurement states is designated, the control unit may control the sample introduction unit to introduce the corresponding sample from the sample holding unit to the measurement device at a time point when a current measurement is completed.
According to the control device of the automatic sampler, by using the measurement schedule state indicating the next measurement as the measurement state, it is possible to easily set and change the next sample to be measured visually on the holding position information reflecting the actual arrangement order (measurement order) of the respective samples. Further, it is possible to easily grasp at which position the sample to be measured is located next. As a result, the sample can be transferred to the measurement without fail by a simple and visually easy operation.
In the control device of an auto-sampler according to the present invention, when there are a plurality of samples for which the measurement reservation status is specified, the control unit may control the sample introduction unit to introduce the samples into the measurement device in order from the samples at the following positions: the position corresponds to the first arrangement of the plurality of samples in the predetermined sequential arrangement order on the sample holding portion.
According to the control device of the automatic sampler, since the measurement reservation status can be specified for a plurality of samples and the measurement order is the actual order of the samples, it is possible to easily grasp at which position the next sample to be measured is located, and since the measurement reservation can be made for a plurality of samples, it is possible to prevent forgetting to measure.
In the control device of an auto-sampler according to the present invention, the control unit may cause measurement selection information indicating whether or not the measurement reservation status is specified to be displayed on the holding position information, and when the user selects the measurement selection information to cancel the specification of the measurement reservation status, the control unit may delete the position of the selected sample and the information of the measurement reservation status from the storage unit and end color discrimination display or highlight display of the sample in which the measurement reservation status is specified to be displayed on the measurement selection information.
According to the control device of the auto-sampler, since the measurement selection information can be selected to specify or cancel the measurement reservation state, the cancellation is easy and the control device is easy to visually grasp.
In the control device of an auto-sampler according to the present invention, the control unit may be configured to display measurement selection information indicating whether or not the measurement reservation status is designated on the holding position information, and when the user selects the designation of the measurement reservation status on the measurement selection information, the control unit may control the sample introduction unit to introduce the corresponding sample from the sample holding unit into the measurement device at a time point when the current measurement is completed.
According to the control device of the auto-sampler, since the measurement selection information can be selected to specify the measurement reservation status, the specification is easy and the user can easily grasp visually.
In the control device for an automatic sampler of the present invention, the storage unit may store the type of the sample and the measurement condition in association with each other in advance, and when an information setting status in which the type of the sample is set in the measurement status is specified by the user in the holding position information, the control unit may prompt the user to set the type of the sample, and store the position of the sample and the type of the sample in association with each other in the storage unit.
According to the control device of the automatic sampler, if the information setting status is specified, the setting of the sample type can be prompted, and therefore, forgetting the setting of the sample type or setting another sample type by mistake can be suppressed, and the setting can be reliably performed.
In the control device for an automatic sampler of the present invention, the storage unit may store in advance a type of the sample at a predetermined position in the holding position information, and the control unit may invalidate the designation when the user designates the information setting status for the sample of which the type is determined in the holding position information.
According to the control device of the automatic sampler, it is possible to prevent the type of the sample from being erroneously changed for a sample whose type is predetermined on the holding position information.
In the control device for an auto-sampler according to the present invention, the control unit may cause the type of the sample for which the type is specified or the type of the sample for which the information setting status is specified to be displayed on the holding position information.
According to the control device of the automatic sampler, the type of the sample located at the holding position can be visually grasped on the holding position information in a lump.
In the control device for an automatic sampler of the present invention, the control unit may invalidate the designation when the measurement reservation status is designated for the sample for which the information setting status is not designated.
According to the control device of the automatic sampler, it is possible to prevent erroneous measurement of a sample in which the type of sample relating to the measurement condition is not specified.
In the control device of an auto-sampler according to the present invention, a standard sample for generating a calibration curve corresponding to the type set in the information setting condition may be held in advance at a predetermined position of the sample holding unit, the storage unit may store a position of the standard sample in advance, and when the information setting condition is specified for a predetermined sample by the user in the holding position information, the control unit may display calibration curve information for specifying whether or not to generate a calibration curve corresponding to the type, and when the user selects generation of the calibration curve in the calibration curve information, the control unit may control the sample introduction unit with reference to the storage unit to introduce the standard sample from the sample holding unit to the measurement device.
According to the control device of the automatic sampler, the user can easily select the meaning of generating the calibration curve by selecting the sample on the holding position information, and the calibration curve is automatically generated according to the type of the sample, so that setting for generating the calibration curve is not required, and errors such as generation of an erroneous calibration curve can be prevented.
In the control device of an auto-sampler according to the present invention, a diluted sample and a container for dilution for generating a calibration curve corresponding to the type set in the information setting condition may be held in advance at a predetermined position of the sample holding unit, the positions of the diluted sample and the container may be stored in advance in the storage unit, and when the user selects the generation of the calibration curve, the control unit may control the sample introduction unit with reference to the storage unit, extract the standard sample and the diluted sample from the sample holding unit, mix them in the container, prepare a standard sample having a plurality of concentrations for generating the calibration curve, and then introduce the container into the measurement device.
In order to generate a calibration curve, a plurality of concentrations of standard samples are required, but there are cases where: it is spatially difficult to hold a plurality of standard samples of respective concentrations in a sample holding portion in advance. Therefore, each time a calibration curve is generated from a standard sample and a diluted sample of one concentration, if a plurality of diluted standard samples of a plurality of concentrations are automatically prepared, the generation of the calibration curve becomes convenient.
In the control device for an autosampler according to the present invention, when the diluted sample and the container are not held at the predetermined position of the sample holding unit, the control unit may display the holding positions of the diluted sample and the container on the holding position information, and may notify the user that the sample at each holding position is the diluted sample and the container based on information set in the information setting status, so as to prompt the user to set the diluted sample and the container.
According to the control device for an automatic sampler, a user can recognize that the diluted sample and the container are forgotten to be set, and a calibration curve can be accurately generated.
In the control device of an auto-sampler according to the present invention, the control unit may automatically assign the in-measurement status as the measurement status to the holding position information for the sample currently introduced into the measurement device, and perform color discrimination display or highlight display, and when the measurement of the sample corresponding to the in-measurement status is completed, the control unit may automatically assign the measurement completion status as the measurement status to the holding position information, and perform color discrimination display or highlight display.
According to the control device of the automatic sampler, since the in-measurement state and the measurement completion state are automatically assigned, the positions of the in-measurement and the measurement completed samples can be visually easily grasped without error.
In the control device for an automatic sampler of the present invention, when one of the measurement statuses is designated by the user for the sample corresponding to the measurement completed status on the held position information, the control unit may store the designated position of the sample in a predetermined storage unit in association with the measurement status.
According to the control device for an automatic sampler, since it is possible to reset any measurement state for all samples in the measurement state except for the state in measurement on the basis of the held position information, it becomes easy to change the setting, for example, to insert a new sample immediately at the position of the sample at which the measurement is completed and to perform the measurement.
In the control device for an autosampler according to the present invention, when the user selects the sample from the holding position information, the control unit may cause corresponding information on the sample to be displayed.
According to the control device of the automatic sampler, by displaying the corresponding information on the selected sample on the holding position information, it is possible to easily acquire the information and to prevent the information of another sample from being erroneously acquired.
In the control device for an auto-sampler according to the present invention, the measurement status may be the measurement completion status, and the control unit may acquire a measurement result of the sample and display the measurement result as the related information.
The automatic measurement system of the present invention includes a control device for the automatic sampler, and the measurement device.
The automated measurement system of the present invention may be a liquid chromatography measurement system.
Effects of the invention
According to the present invention, it is possible to obtain a control device for an automatic sampler, which can easily set and change a measurement state of a sample on holding position information indicating an actual sample holding position, and which can easily grasp the measurement state.
Drawings
Fig. 1 is a diagram showing a configuration of an automatic measurement system (liquid chromatography apparatus) according to an embodiment of the present invention.
Fig. 2 is a diagram showing the structure of an auto-sampler.
Fig. 3 is a diagram showing the holding position information displayed on the display unit.
Fig. 4 is a diagram showing a case where the user specifies one of the measurement statuses of the predetermined sample on the holding position information.
Fig. 5 is a diagram showing an information setting window that urges the user to set the sample type when the information setting status is specified by the user.
Fig. 6 is a diagram showing a case where the user designates the measurement reservation status.
Fig. 7 is a diagram showing a case where the user has released the measurement reservation status.
Fig. 8 is a diagram showing a table stored in the storage section.
Fig. 9 is a diagram showing a case where the measurement result is displayed when the user selects a predetermined sample on the holding position information.
Fig. 10 is a diagram showing another example of the sample holding portion and holding position information indicating the sample holding portion.
Fig. 11 is a schematic diagram showing a diluted sample and a dilution container for generating a calibration curve held in a sample holding portion.
Fig. 12 is a diagram showing a method for specifying a measurement procedure of a sample in a conventional automatic sampler.
Description of the reference numerals
3: an automatic sampler; 3 a: a sample holding section; 3 b: a sample introduction section; 6: a detector (measuring device); 7: data processing means (control means for the auto-sampler); 8: a storage unit; 9: a control unit; 10: a display unit; 100: liquid chromatographs (automatic measurement systems); 201a to 201 c: vials (test specimens); 201 d: a container for dilution (empty container); 300: maintaining the position information; 302: a holding position; 304: check box (measurement selection information); 306: the type of sample; 312: information setting status; 312 Wd: check buttons (check line information); 314: measuring the reservation status; 316: determining a medium condition; 318: a measurement completion status; u: an input by a user.
Detailed Description
Hereinafter, embodiments of the present invention will be described with reference to the drawings. Fig. 1 is a diagram showing a configuration of an automatic measurement system (liquid chromatography apparatus) 100 according to an embodiment of the present invention.
The liquid chromatography apparatus 100 is an apparatus for performing qualitative or quantitative analysis of a predetermined measurement object, and includes a data processing apparatus (control unit) 7 for controlling the whole, a mobile phase (mixed solution of eluent and solvent) 1, a pump 2 for transporting the mobile phase 1, an autosampler 3 for injecting a sample, a column 4 for separating components, a column oven 5 for keeping the column 4 at a constant temperature, a detector 6 for detecting the separated components, and a display unit 10.
The data processing device 7 is constituted by a computer having a control unit (CPU)9 and a storage unit (hard disk or the like) 8, wherein the control unit (CPU)9 executes analysis and analyzes the analysis result, and the storage unit (hard disk or the like) 8 stores the analysis result or the analysis result. The display unit (monitor) 10 displays the analysis result and the analysis result, and is a touch panel that can be used by the user U to make various inputs, selections, settings, and the like on the display unit 10, instead of a keyboard or the like.
The detector 6 corresponds to the "measuring device" of the claims. The data processing device 7 corresponds to "control device of auto sampler" in the claims. That is, the control device of the auto-sampler according to the embodiment of the present invention can be additionally applied to all measurement devices.
The liquid chromatography apparatus 100 corresponds to the "automatic measurement system" in the claims.
The detector 6 has elements for detecting signal strength with respect to time. As the detector, a three-dimensional detector having a plurality of detection elements and capable of simultaneously acquiring at a plurality of wavelengths can be used.
The sample is injected from a syringe (not shown) of the autosampler 3, and is separated into various components in the sample by passing through the column 4 together with the mobile phase 1 fed from the pump 2.
The sample separated into the components is detected by the detector 6. The signal of the detector 6 is sent to a data processing device 7 for data processing.
The column 4 is a device that is generally used as a separation section for separating components of a sample present in the mobile phase 1. As the column 4, there are a packed column, a monolithic column, and the like. As the column packing material of the column 4, various types of packing materials such as an adsorption type, a distribution type, and an ion exchange type can be used. The column 4 is preferably placed in a column oven 5 so that the column 4 is kept at a constant temperature, whereby the separation of the sample can be performed with good reproducibility.
The storage unit 8 stores measurement conditions, calibration curve data, and the like for each sample. As shown in fig. 8, the storage unit 8 stores the measurement state and the type of sample for each holding position (serial number) of the following samples in table 8 t.
As shown in fig. 2, the auto-sampler 3 includes: a sample holding unit 3a for holding a plurality of samples (vials) 201a and 201b in an aligned manner; and a sample introduction portion 3b for introducing a plurality of samples one by one into the measurement device.
Here, the sample holding portion 3a is a holder having 10 holding holes 3h for holding the samples 201a and 201b … … in a row, and the measurement is performed sequentially from the left side of fig. 2 in the sequential arrangement order (sequence) of the holding holes 3 h.
The sample introduction portion 3b includes: an arm 3 t; a needle-equipped head 3s provided on the lower surface of the arm 3t and configured to introduce a plurality of samples one by one into the measurement device (detector 6); and a moving mechanism (not shown, and a known actuator) that moves the arm 3t in the planar direction and the vertical direction.
In this example, the sample is a liquid, and is put into a vial (container) and sealed with a cap. Then, the needle-equipped head 3s is inserted into the cap of the vial, and the sample inside the vial is aspirated and introduced into the syringe.
In this case, the sample directly placed on the sample holding portion such as a turntable may be grasped by a grasping portion provided in the sample introduction portion and carried into the measurement apparatus.
Therefore, in the present invention, "introduction" includes a case where a sample such as a liquid in a container is moved to a measurement site of a measurement device without moving the container held in a sample holding section; and a case where the sample is directly moved to a measurement site of the measurement device.
In addition, the measurement device may be exemplified by a fluorescent X-ray analyzer or the like in addition to the detector 6, but is not limited thereto.
Next, with reference to fig. 3 to 9, an operation of the control unit 9 based on an operation performed by a user while viewing the display screen of the display unit 10 will be described.
Fig. 3 shows holding position information 300 displayed on the display unit 10 by the control of the control unit 9, the holding position information 300 indicating the holding positions of the plurality of samples in the sample holding unit 3 a.
In the example of fig. 3, the auto-sampler 3 may be provided with two sample holding portions 3a, each holding 10 samples (vials) in a row, wherein the actual sample holding portion 3a corresponding to the upper stage 300x of the holding position information 300 holds a predetermined type of sample such as Blank or Std. On the other hand, the actual sample holding portion 3a corresponding to the lower stage 300y is provided to hold UNK (unknown sample) in which no sample (vial) is put into some of the holding holes 3 h.
Here, taking the lower stage 300y of the holding position information 300 as an example, the holding positions 302 of the respective samples are shown by circles, and inside the circles, a sequential order of arrangement (serial number) is shown. The order of measurement of the samples (the order of introduction into the detector 6) is in the order of the sequence numbers from the first to the last, and in this example, measurement is performed from 1 to 10 to the right in the order from the left side (blank) of the upper stage 300x of the holding position information 300, and measurement is performed from 11 to 20 to the right in the order from the left side of the lower stage 300 y.
The type (blank, CBZ, UNK, etc.) 306 of the sample is displayed on the upper part of the holding position 302, and measurement selection information (check box) 304 described later is displayed on the lower part of the holding position 302.
Fig. 4 shows a case where the user U designates one of the measurement statuses of the predetermined sample (serial number 15) on the holding position information 300.
The measurement status indicates any one of a plurality of measurement statuses, and in the present example, an unset status 310 (in fig. 4, each sample is surrounded by an open circle), an information setting status 312 (in fig. 4, each sample is surrounded by a circle hatched in gray), and a measurement reservation status, a measurement in progress status, and a measurement completed status, which will be described later, are assigned.
The control unit 9 automatically assigns the unset status 310, the measurement status, and the measurement completion status even if the user U does not specify the unset status, the measurement status, or the measurement completion status.
The unset state 310 is a state in which the measurement state is not set, except for the state during measurement and the state after measurement.
For example, after the sample for which the measurement reservation status 314 is designated is introduced into the detector 6, the control unit 9 receives a signal during measurement from the detector 6 side, and the like, and thereby can recognize that the sample is being measured.
For example, the controller 9 can recognize that the measurement is completed by receiving a signal indicating that the measurement is completed (or data of the measurement result) from the detector 6.
In fig. 4, for example, when the user U clicks on the sample (serial number 15) and clicks on the information setting status 312 as the measurement status, the control unit causes the display unit 10 to display the information setting window 312W of fig. 5 so as to overlap the holding position information 300.
In the input box 312Wa of the information setting window 312W in fig. 5, the user U is prompted to set the sample type and appropriately input the sample type in the input box 312Wa, or selects the type with a selection bar or the like when a candidate for the type is determined in advance, and clicks the setting button 312Wb to determine the selection. In FIG. 5, Carbamazepine (CBZ for short) was selected. When the setting button 312Wb is clicked, the information setting condition 312 is determined for the first time.
Thus, the control unit 9 stores the position (serial number 15) of the sample, the information setting status 312, and the type of sample (carbamazepine) in the storage unit 8 in association with each other. Further, the control unit 9 displays the sample (serial number 15) in which the information setting status 312 is specified, in a color-differentiated or highlighted manner on the holding position information 300. In this example, the sample (serial number 15) is displayed in a color-differentiated manner by a gray hatching.
In this way, in fig. 4, 3 consecutive samples (serial numbers 13 to 15) are displayed in different colors to indicate the information setting status 312.
As described above, in the present embodiment, by selecting samples from the holding position information 300 indicating the holding positions 302 in which the actual order of arrangement (measurement order) of the respective samples is reflected, the measurement state of each sample can be easily set and changed visually in accordance with the order of arrangement of the samples.
Further, since the measurement status of each of the designated samples is displayed in a color-distinguished manner or highlighted, the order of the arrangement of the samples and the measurement status of the samples can be visually and easily grasped.
As a result, the sample can be easily replaced before measurement, and insertion measurement of other samples and the like can be easily performed while observing the measurement state.
Next, the measurement reservation state will be described with reference to fig. 6. In this example, the user U checks the measurement selection information (check box) 304 for the sample (serial number 15) to specify the measurement reservation status 314.
The control unit 9 displays the sample (serial number 15) in which the measurement reservation status 314 is designated, in a color-differentiated manner by oblique hatching, and stores the position of the sample (serial number 15) in the storage unit 8 in association with the measurement reservation status 314.
The control unit 9 controls the sample introduction unit 3b to introduce the sample (serial numbers 13 and 15) for which the measurement reservation status 314 is designated into the detector 6 at the time when the current measurement (sample of serial number 12) is completed.
Thus, the samples of SEQ ID Nos. 13 and 15 were measured in order.
In addition, at the time of measurement, the control unit 9 refers to the storage unit 8, transmits the measurement conditions corresponding to the type (carbamazepine) of the sample to be measured (serial number 15) to the detector 6, and the detector 6 performs measurement according to the conditions.
Here, the measurement status 316 is automatically assigned to the sample (serial number 12) currently being measured, and is displayed in a color-differentiated manner by horizontal hatching.
The measurement completion status 318 is automatically assigned to the measured sample (serial No. 11) and is displayed in a color-distinguished manner by cross-hatching.
As shown in fig. 6, when the user U designates the measurement reservation status 314 for the sample (for example, serial number 19) in which the information setting status 312 is not designated (that is, in the non-setting status 310), the control unit 9 invalidates the designation.
This prevents erroneous measurement of a sample for which the type of sample relating to the measurement condition is not specified.
Here, as shown in fig. 6, when there are a plurality of samples (serial numbers 13 and 15) for which the measurement reservation status 314 is designated, the control unit 9 introduces the samples into the detector 6 in order from the samples at the following positions: this position corresponds to the first serial number in the consecutive arrangement (sequence) of the samples in the sample holding portion 3a, which is determined in advance. That is, the measurement is performed in the order of the sequence numbers 13 and 15.
On the other hand, as shown in fig. 7, the user U may cancel the check of the check box 304 to cancel (cancel) the measurement reservation status 314. In fig. 7, the measurement reservation status 314 of the sample of the serial number 13 is cancelled, and the control unit 9 deletes the position of the sample of the serial number 13 and the information of the measurement reservation status from the storage unit 8, and ends the color distinction display or highlight display of the sample as the measurement reservation status 314 of the serial number 13. When the check is cancelled, the condition reverts to the previous state display.
Thus, the measurement of the sample of serial No. 13 was stopped, and the measurement of the sample of serial No. 15, which is the second previous serial No., was performed.
As described above, in the present embodiment, by using the measurement schedule indicating the next measurement as the measurement schedule, the sample to be measured next can be easily set and changed visually on the holding position information 300 reflecting the actual order of arrangement of the samples (measurement order). Further, it is possible to easily grasp at which position the sample to be measured is located next.
In addition, since the measurement reservation status can be specified for a plurality of samples in the order in which the samples are actually arranged, it is possible to easily grasp at which position the next sample to be measured is located, and since the measurement reservation can be made for a plurality of samples, forgetting to measure can be prevented.
Further, by checking the measurement selection information (check box) 304, the measurement reservation status can be designated or canceled, so that designation and cancellation become easy and are visually easy to grasp.
Next, returning to fig. 5, measurement of the calibration curve will be described.
In the information setting window 312W of fig. 5, when the user U checks a check button (calibration curve information) 312Wd for generating a calibration curve, the control unit 9 automatically generates a calibration curve for the sample type (carbamazepine) designated in the information setting window 312W.
First, as shown in the sample (serial number 3) at the upper stage 300x of the holding position information 300 in fig. 4, a standard sample for creating a calibration curve corresponding to the type of sample (carbamazepine: CBZ) is held in advance at a predetermined position of the actual sample holding unit 3a, and the position of the standard sample is stored in advance in the storage unit 8.
The control unit 9 controls the sample introduction unit 3b with reference to the storage unit 8, and introduces the standard sample of CBZ of sequence No. 3 from the actual sample holding unit 3a to the detector 6, and performs a calibration curve measurement.
Here, in order to generate a calibration curve, a plurality of concentrations of standard samples are required, but there are cases where: it is spatially difficult to hold a plurality of standard samples of respective concentrations in a sample holding portion in advance. Therefore, the diluted standard samples of a plurality of concentrations may be prepared each time a calibration curve is generated from a standard sample of one concentration (the standard sample of CBZ of serial No. 3).
Fig. 11 shows a diluted sample (diluent) 201c for generating a calibration curve held in the sample holding portion 3a and an empty container 201d for dilution. The diluted sample (vial) 201c is filled with a diluent 201 s. In fig. 11, the diluted sample 201c and the empty container 201d correspond to serial numbers 9 and 10 in fig. 3, respectively.
The storage unit 8 stores the positions of the diluted sample 201c and the container 201d in advance.
Then, when the user U checks the check button (calibration curve information) 312Wd for generating the calibration curve, the control unit 9 refers to the storage unit 8 to control the sample introduction unit 3b, and takes out the standard sample of CBZ of serial No. 3 from the actual sample holding unit 3a, mixes the standard sample in the container 201d, and prepares the diluted standard samples of a plurality of concentrations. Then, the controller 9 introduces the diluted standard sample placed in the container 201d of serial No. 10 into the detector 6, and performs a calibration curve measurement.
Further, the diluted sample 201c and the empty container 201d may not be held at predetermined positions (serial numbers 9 and 10) of the sample holding portion 3 a.
Therefore, when the controller 9 detects this state, the holding positions (serial numbers 9 and 10) of the diluted sample 201c and the container 201d are displayed on the holding position information 300. In addition, the information setting status is defined as "diluted sample" and "empty container" for serial numbers 9 and 10, respectively.
Therefore, the control unit 9 notifies that the sample at each holding position is a diluted sample or a container based on the information set for the information setting status, and urges the user to set the diluted sample 201c and the empty container 201 d.
The report is not particularly limited, and the "diluted sample" and the "empty container" may be displayed on the holding positions (serial numbers 9 and 10) of the diluted sample 201c and the container 201d, respectively, in the holding position information 300, and the display may be a color distinction display or an emphasis display such as a blinking display.
Further, on the display screen of the display unit 10, "diluted sample" and "empty container" may be provided by displaying on the holding positions (serial numbers 9 and 10) by a logo, a telop, or the like different from the holding position information 300. Further, the notification may be made by voice.
As described above, by selecting a sample on the holding position information 300, the user can easily select the meaning of generating a calibration curve, and a calibration curve is automatically generated according to the type of the sample, so that setting for generating a calibration curve is not necessary, and an error such as generation of an erroneous calibration curve can be prevented.
In this example, the sample type is predetermined for all the samples in the upper stage 300x of the holding position information 300 in fig. 4, and this type is prevented from being erroneously changed.
That is, as shown in fig. 6, even if the user U sets the status of the sample specification information (for example, serial number 3) of the upper stage 300x, the control unit 9 invalidates the specification.
In this example, the type 306 of the sample (blank, CBZ, etc.) is displayed in the upper stage 300x of the holding position information 300 in fig. 4.
On the other hand, in the lower stage 300y, UNK is uniformly displayed as the type 306 of the sample. However, the type of sample (e.g., CBZ) for which the information setting status 312 is specified may be displayed in the lower stage 300 y.
As described above, by displaying the type 306 of the sample, the type of the sample located at the holding position 302 can be visually grasped in a lump on the holding position information 300.
In this example, any measurement state can be reset for all samples in the measurement state except for the during-measurement state 316 on the held position information 300.
For example, in fig. 7, the information setting status 312 or the new measurement reservation status 314 can be specified for the measured sample (serial number 11) and the sample (serial number 13) from which the measurement reservation status 314 has been removed. The sample in the unset state 310 can be, of course, designated as the information setting state 312 or the measurement reservation state 314.
In the information setting window 312W of fig. 5, when the user U clicks the "clear sample information" button 312Wc, the sample type set in the information setting status 312 is cleared (deleted). In this example, default setting is performed so as to be an unset state 310 of a white circle.
As described above, since any measurement situation can be reset for the samples in all measurement situations except the during-measurement situation 316 on the held position information 300, it becomes easy to change the setting such as, for example, immediately inserting a new sample at the position of the sample at which the measurement is completed and performing the measurement.
In this example, when the user U selects a predetermined sample from the holding position information 300, the control unit 9 may display corresponding information on the sample.
For example, if the selected sample is the information setting status 312 or the measurement reservation status 314, the type of the sample can be displayed.
As shown in fig. 9, if the selected sample is the measurement completed state 318, the measurement result can be displayed.
As described above, by displaying the corresponding information on the selected sample on the holding position information 300, it is possible to easily acquire the information and prevent the information of another sample from being erroneously acquired.
The present invention is not limited to the above-described embodiments, and naturally, it relates to various modifications and equivalents included in the spirit and scope of the present invention.
The form of the sample holding portion and the holding position information indicating the sample holding portion is not limited, and for example, as shown in fig. 10, the form may be such that samples are arranged and held along the circumferential direction of a circular sample holding portion.
The measurement conditions are not limited to the color-differentiated display, and may be highlighted by blinking or the like.
The sample holding portion and the holding position information indicating the sample holding portion are not limited to the one-row arrangement as shown in fig. 3, and may be in a form in which each sample is held along the circumferential direction of a circular sample holding portion, for example, as shown in fig. 10.
Claims (18)
1. A control device for an automatic sampler comprising a sample holding unit for holding a plurality of samples in an aligned manner and a sample introduction unit for introducing the plurality of samples one by one into a measurement device, the control device comprising a control unit and a storage unit,
the control unit causes a predetermined display unit to display holding position information indicating the holding positions of the plurality of samples in the sample holding unit,
when one of a plurality of measurement conditions indicating a measurement state of the predetermined sample is specified by the user on the holding position information, the control unit stores the specified position of the sample and the specified measurement condition in the storage unit in association with each other,
the control unit may cause the sample to be displayed with a color distinction or a highlight on the holding position information.
2. The control device of an auto-sampler according to claim 1,
when a measurement reservation state indicating a next measurement among the measurement states is designated, the control unit controls the sample introduction unit to introduce the corresponding sample from the sample holding unit to the measurement device at a time point when the current measurement is completed.
3. The control device of an auto-sampler according to claim 2,
when there are a plurality of samples to which the measurement reservation status is designated,
the control unit controls the sample introduction unit to introduce the samples into the measurement device in order from the samples at the following positions: the position corresponds to the first arrangement of the plurality of samples in the predetermined sequential arrangement order on the sample holding portion.
4. The control device of an auto-sampler according to claim 2 or 3, wherein,
the control unit causes measurement selection information indicating whether or not the measurement reservation status is specified to be displayed on the holding position information,
when the user selects the measurement selection information to cancel the specification of the measurement reservation status,
the control unit deletes the position of the selected sample and the information on the measurement reservation status from the storage unit, and ends the color distinction display or the highlight display of the sample in which the measurement reservation status is specified on the measurement selection information.
5. The control device of an auto-sampler according to any one of claims 2 to 4, wherein,
the control unit causes measurement selection information indicating whether or not the measurement reservation status is specified to be displayed on the holding position information,
when the user selects the measurement selection information to designate the measurement reservation status,
the control unit controls the sample introduction unit to introduce the corresponding sample from the sample holding unit to the measurement device at a time when the current measurement is completed.
6. The control device of an auto-sampler according to any one of claims 1 to 5, wherein,
the storage unit stores the types of the samples and the measurement conditions in association with each other in advance,
when the user specifies the information setting condition for setting the type of the sample in the measurement condition on the holding position information, the control unit urges the user to set the type of the sample, and stores the position of the sample and the type of the sample in the storage unit in association with each other.
7. The control device of an auto-sampler according to claim 6,
the storage unit stores in advance the type of the sample at a predetermined position on the holding position information,
when the user designates the information setting condition on the holding position information for the sample for which the type is specified, the control unit invalidates the designation.
8. The control device of an auto-sampler according to claim 6 or 7,
the control unit causes the holding position information to display the type of the sample for which the type is specified or the type of the sample for which the information setting condition is specified.
9. The control device of an auto-sampler according to claim 8,
the control unit invalidates the designation when the measurement reservation status is designated for the sample for which the information setting status is not designated.
10. The control device of an auto-sampler according to any one of claims 6 to 9, wherein,
a standard sample for generating a calibration curve corresponding to the type set in the information setting condition is held in advance at a predetermined position of the sample holding portion,
the storage unit stores the position of the standard sample in advance,
when the user designates the information setting condition for a predetermined sample on the holding position information, the control unit displays calibration curve information for designating whether or not to generate a calibration curve corresponding to the type,
when the user selects the formation of the calibration curve from the calibration curve information,
the control unit controls the sample introduction unit with reference to the storage unit, and introduces the standard sample from the sample holding unit to the measurement device.
11. The control device of an auto-sampler according to claim 10,
a diluted sample and a container for dilution for generating a calibration curve corresponding to the type set in the information setting condition are held in advance at predetermined positions of the sample holding portion,
the storage unit stores positions of the diluted sample and the container in advance,
when the user selects the meaning of generating the calibration curve,
the control unit controls the sample introduction unit with reference to the storage unit, takes out the standard sample and the diluted sample from the sample holding unit, mixes the standard sample and the diluted sample in the container, prepares a standard sample having a plurality of concentrations for generating the calibration curve, and then introduces the container into the measurement device.
12. The control device of an auto-sampler according to claim 11,
when the diluted sample and the container are not held at a predetermined position of the sample holding portion,
the control unit displays the holding positions of the diluted sample and the container on the holding position information, and reports that the sample at each holding position is the diluted sample and the container based on the information set in the information setting status, thereby prompting the user to set the diluted sample and the container.
13. The control device of an auto-sampler according to any one of claims 1 to 12, wherein,
the control unit automatically assigns the in-measurement situation as the measurement situation on the holding position information for the sample currently introduced into the measurement device, and performs color discrimination display or highlight display,
when the measurement of the sample according to the in-measurement state is completed, the control unit automatically assigns a measurement completion state as the measurement state to the holding position information, and performs color discrimination display or highlight display.
14. The control device of an auto-sampler according to claim 13,
when one of the measurement situations is designated by the user for the sample corresponding to the measurement completion situation on the held position information, the control unit stores the designated position of the sample in a predetermined storage unit in association with the measurement situation.
15. The control device of an auto-sampler according to any one of claims 1 to 14, wherein,
when the sample is selected on the holding position information by the user, the control section causes corresponding information related to the sample to be displayed.
16. The control device of an auto-sampler according to claim 11,
the control section causes, when the sample is selected on the holding position information by the user, corresponding information related to the sample to be displayed,
the measurement status is the measurement-completed status,
the control unit acquires the measurement result of the sample and displays the measurement result as related information.
17. An automated assay system, comprising:
control means of an autosampler according to any of claims 1 to 16;
the automatic sampler; and
the measuring device.
18. The automated assay system of claim 17,
the automated assay system is a liquid chromatography assay system.
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| JP3029330B2 (en) * | 1991-09-13 | 2000-04-04 | 株式会社東芝 | Automatic chemical analyzer |
| JP3314546B2 (en) * | 1994-09-14 | 2002-08-12 | 株式会社日立製作所 | Automatic analyzer |
| JPH09325096A (en) * | 1996-06-05 | 1997-12-16 | Shimadzu Corp | Auto sampler |
| JP3394744B2 (en) | 2000-06-20 | 2003-04-07 | 理学電機工業株式会社 | Sample information setting method and analysis system |
| JP2010190779A (en) | 2009-02-19 | 2010-09-02 | Hitachi High-Technologies Corp | Automatic analyzer |
| EP2485054B1 (en) | 2009-09-28 | 2019-08-21 | Hitachi High-Technologies Corporation | Automatic analyzing device, information display method thereof, and information display system |
| CN103370626A (en) | 2011-03-03 | 2013-10-23 | 株式会社日立高新技术 | Specimen data processing device for analysis device, auto-sampler device, liquid chromatograph device, specimen data processing method, and analysis method |
| US10890566B2 (en) | 2013-08-28 | 2021-01-12 | Shimadzu Corporation | Automatic analysis control device and program |
| JP6264997B2 (en) | 2014-03-27 | 2018-01-24 | 株式会社島津製作所 | Control device for automatic analyzer |
| JP6418017B2 (en) | 2015-03-13 | 2018-11-07 | 株式会社島津製作所 | Pre-processing apparatus and analysis system provided with the same |
| JP2017125721A (en) | 2016-01-13 | 2017-07-20 | 日本電子株式会社 | Automatic analyzer and notification information display method |
| CN111356925B (en) | 2017-12-05 | 2023-10-03 | 株式会社岛津制作所 | Automatic analysis system |
| KR20220062059A (en) | 2019-09-17 | 2022-05-13 | 베크만 컬터, 인코포레이티드 | Automated Reagent Identification for Fluid Handling Systems |
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