CN112604144A

CN112604144A - 3D prints multichannel model stopper of vagina and executes source ware

Info

Publication number: CN112604144A
Application number: CN202011521804.8A
Authority: CN
Inventors: 张春林
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-12-21
Filing date: 2020-12-21
Publication date: 2021-04-06
Anticipated expiration: 2040-12-21
Also published as: CN112604144B

Abstract

The invention discloses a 3D printing vagina multi-channel model plug applicator, which relates to the technical field of cervical cancer brachytherapy, and comprises an applicator and insertion needles, wherein the applicator is formed by 3D printing and is used for accurately matching with the vagina of a patient, the end part of the applicator is inserted into the vagina of the patient, a plurality of flexible insertion needles are fixedly arranged at the end part of the applicator, the flexible insertion needles are inserted into the tumor of the patient and used for radiotherapy and chemotherapy of the patient, the 3D printing individualized applicator is customized according to the image data of the patient and by combining the physiological structure of the patient, the number of source channels is large, the matching degree with the tumor structure is high, the three-dimensional conformal degree is more excellent, and the patient can use the applicator independently, thereby really avoiding cross infection. The source channel can deflect by combining a flexible insertion needle, the needle does not need to be inserted from the perineum for eccentric tumors, the operation difficulty is reduced, the pain of a patient is relieved, various types of channels can be arranged on one source applicator according to requirements, and cervical tumors, uterine tumors and vaginal tumors can be treated simultaneously.

Description

3D prints multichannel model stopper of vagina and executes source ware

Technical Field

The invention relates to the technical field of cervical cancer brachytherapy, in particular to a 3D printing vaginal multichannel model plug applicator.

Background

The main modes of radical radiotherapy for local advanced cervical cancer are pelvic external irradiation (EBRT), postloading intracavitary Brachytherapy (BT) and cisplatin-based synchronous radiotherapy and chemotherapy, the BT has great influence on the treatment effect, and whether a patient carries out BT or not, and the difference of the local control rates of the BT and the BT can reach 20%. The three-dimensional brachytherapy enables better treatment of cervical cancer and reduces the occurrence of complications. The traditional treatment means must depend on experience accumulation, lacks advanced individualized technical support and is difficult to realize 'tailoring' due to the diversification of human bodies and the different positions and shapes of the focus. The main modes of radical radiotherapy for local advanced cervical cancer are pelvic external irradiation (EBRT), postloading intracavitary Brachytherapy (BT) and cisplatin-based synchronous radiotherapy and chemotherapy, the BT has great influence on the treatment effect, and whether a patient carries out BT or not, and the difference of the local control rates of the BT and the BT can reach 20%. The three-dimensional brachytherapy enables better treatment of cervical cancer and reduces the occurrence of complications. The traditional treatment means must depend on experience accumulation, lacks advanced individualized technical support and is difficult to realize 'tailoring' due to the diversification of human bodies and the different positions and shapes of the focus. The multi-channel applicator can change the residence point and the weight distribution, and increase the focus irradiation and OAR protection. Therefore, the multi-channel vaginal model plug is manufactured by using the 3D printing technology, so that the patient can be measured and optimized difficultly by using conventional applicators such as local large tumors, vaginal invasion and the like, the tumor exposure is improved, the normal tissue exposure is reduced, and the curative effect is improved.

Disclosure of Invention

Aiming at the problems in the prior art, the invention aims to provide a 3D printing vaginal multi-channel model plug applicator, a 3D printing technology guides cervical cancer postradiotherapy, an individual uterine cavity applicator is formulated for a patient according to different disease conditions, the individual uterine cavity applicator is customized according to image data of the patient and the physiological structure of the patient, the number of source channels is large, the matching degree with a tumor structure is high, and the three-dimensional conformal degree is more excellent.

In order to achieve the purpose, the invention provides the following technical scheme: the device comprises an applicator and insertion needles, wherein the applicator is formed by 3D printing and is used for accurately matching the vagina of a patient, the end part of the applicator is inserted into the vagina of the patient, a plurality of flexible insertion needles are fixedly arranged at the end part of the applicator, and the flexible insertion needles are inserted into the tumor of the patient to carry out radiotherapy and chemotherapy on the patient.

As a further scheme of the invention: the working process of the applicator comprises the following steps:

the method comprises the following steps: the method comprises the steps of collecting image data CT and MRI of a patient, establishing a tumor model of the patient, determining the type, position, shape and size of a tumor, and simultaneously delineating a target area and a low tolerance area.

Step two: the source distribution channel is designed according to the medical history of a patient, firstly, the vagina is stuffed, the vagina is expanded to a comfortable degree, the same expansion degree is kept among the treatments, and then nuclear magnetic resonance is carried out to obtain the bending degree of the uterus body, the length of the uterine cavity and the length of the vagina so as to determine the design parameters of the applicator.

Step three: designing a source applicator according to a source distribution scheme and patient image data, generally reconstructing a vaginal model and a tumor model of a patient according to the data information acquired in the step two, then modeling and setting the source applicator by adopting three-dimensional modeling software to simulate a treatment process, and finally implementing 3D printing, wherein the 3D printed material is a transparent or semitransparent material.

Step four: and (5) performing quality inspection and disinfection on the applicator.

As a further scheme of the invention: the inserting needle of the applicator comprises an auxiliary inserting needle and a main inserting needle, wherein the end part of the applicator is provided with four blind holes according to the tumor position of a patient, the auxiliary inserting needle is fixedly arranged in the blind holes, meanwhile, the middle position of the applicator is provided with a rectangular groove, and the main inserting needle is slidably inserted in the rectangular groove.

As a further scheme of the invention: solid water is selected as the 3D printing material.

As a further scheme of the invention: and a lifting block is fixedly arranged on the side wall of the bottom of the applicator.

As a further scheme of the invention: the target area range is a range area subjected to radioactive source treatment, and the range area is adapted to the diseased range of skin cancer or skin lymphoma on the surface of a patient.

As a further scheme of the invention: the design parameters of the applicator include: size information of the binding surface, thickness information and channel information of the radioactive source.

As a further scheme of the invention: the fitting surface is generally consistent with the body surface of a patient undergoing radioactive source treatment, so that the placing can be kept stable.

As a further scheme of the invention: the thickness information and the radiation source passage information can be set according to the actual condition of the affected area of the patient.

As a still further scheme of the invention: a plurality of channels are formed in the applicator, and insertion needles with various types of channels are inserted into the channels.

Compared with the prior art, the invention has the beneficial effects that: the present brachytherapy adapter has only three channels, the model is single and fixed, good dose distribution and poor adaptability are difficult to achieve for patients with large cervical tumors, eccentric growth and long vaginal invasion, and the individualized multichannel vaginal model plug is manufactured by 3D printing technology as an applicator aiming at the conditions, so that better dose distribution and better adaptability are achieved, the tumor acceptance is improved, the rectal bladder acceptance is reduced, the curative effect is improved, and the radiotherapy complications are reduced.

Meanwhile, the 3D printing individual applicator is customized according to the image data of the patient and by combining the physiological structure of the patient, the number of source channels is large, the matching degree with the tumor structure is high, the three-dimensional conformity degree is better, and the individual applicator can be used by the patient independently, thereby really avoiding cross infection. The source channel can deflect by combining a flexible insertion needle, the needle does not need to be inserted from the perineum for eccentric tumors, the operation difficulty is reduced, the pain of a patient is relieved, various types of channels can be arranged on one source applicator according to requirements, and cervical tumors, uterine tumors and vaginal tumors can be treated simultaneously.

Drawings

Fig. 1 is a schematic view of the working state of the present invention.

FIG. 2 is a schematic diagram of the structure of the applicator of the present invention.

As shown in the figure: 1. applicator, 2, vagina, 3, tumor, 4, auxiliary insertion needle, 5, main insertion needle, 6, rectangular groove, 7 and lifting block.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "disposed," "sleeved/connected," "connected," and the like are to be construed broadly, e.g., "connected," which may be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

Referring to fig. 1-2, in the embodiment of the present invention, a 3D printed vaginal multi-channel model plug applicator includes an applicator 1 and an insertion needle, wherein the applicator 1 is formed by 3D printing and is used for accurately matching with a vagina 4 of a patient, an end of the applicator 1 is inserted into the vagina 4 of the patient, a plurality of flexible insertion needles are fixedly installed at an end of the applicator 1, and the flexible insertion needles are inserted into a tumor 3 of the patient to perform radiotherapy and chemotherapy on the patient.

Specifically, the working process of the applicator 1 includes the following steps:

the method comprises the following steps: the method comprises the steps of collecting CT and MRI image data of a patient, establishing a tumor model of the patient, determining the type, position, shape and size of the tumor, and simultaneously delineating a target area and a low tolerance area, wherein the range of the target area is a range area for radioactive source treatment, and the range area is adapted to the diseased range of skin cancer or skin lymphoma on the surface of the patient.

Step two: design the source channel in combination with patient's medical history, pack vagina 2 at first, expand vagina 2 vagina to comfortable degree, and keep the same expansion degree between the fractionated treatment, be favorable to later stage dose accumulation and accurate aassessment patient's dose distribution at whole treatment course, avoided adopting stretch yarn or cotton ball to pack the vagina, and can accurate arrival focus position of cervical applicator, realize real brachytherapy, reduce the wound to the patient, improve the dose conformity degree of tumour target area and reduce the irradiated dose of important organ, and then improved cervical carcinoma brachytherapy's curative effect, carry out nuclear magnetic resonance afterwards, obtain the bending degree of uterus body, the length of uterine cavity, vaginal length, confirm applicator's design parameter, include: adhesive surface

The device comprises size information, thickness information and radioactive source channel information, wherein the attaching surface is generally attached to the body surface of a patient for radioactive source treatment, so that the attaching surface can be stably placed; the thickness information and the radiation source passage information can be set according to the actual condition of the affected area of the patient.

Step three: designing a source applicator according to a source distribution scheme and patient image data, generally reconstructing a vagina 2 model and a tumor 3 model of a patient according to data information acquired in the step two, then modeling and setting the source applicator 1 by adopting three-dimensional modeling software to simulate a treatment process, and finally performing 3D printing, wherein the three-dimensional modeling software and the 3D printing machine are common equipment on the market, and are common knowledge of people in the technical field, so that the detailed description is omitted, meanwhile, the 3D printing material is transparent or semitransparent material, so that an internal insertion needle channel is convenient to observe, the use of the source applicator 1 by medical personnel is convenient, an individual uterine cavity source applicator is established for the patient according to different disease conditions, the source applicator is customized according to the patient image data and by combining with the physiological structure of the patient, the number of the source channels is large, the matching degree with the tumor structure is high, and the three-dimensional conformity degree is more excellent.

Step four: the applicator 1 is subjected to quality inspection and sterilization, so that the cleanness of the applicator 1 is ensured, and the infection of the applicator 1 to the vagina of a patient in the using process is avoided.

The first embodiment is as follows:

wherein, the needle of planting of inserting of applicator 1 includes vice needle 4 of planting and main needle 5 of planting of inserting, wherein four blind holes that the tip of applicator 1 was seted up according to patient's tumour position, vice needle 4 fixed mounting of planting is in the blind hole, it reaches better dose distribution to insert through four pairs needle 4 of planting, improve tumour burden, reduce rectum bladder burden, improve the curative effect, reduce radiotherapy complication, rectangular channel 6 has been seted up to the intermediate position of applicator 1 simultaneously, main needle 5 of planting is inserted to sliding in rectangular channel 6, combine the setting of rectangular channel 6, make the source passageway angle of can deflecting, need not to follow the perineum needle of inserting to eccentric tumour, reduce the operation degree of difficulty, alleviate patient's misery.

Preferably, the 3D printing material selects solid water for use, is convenient to recover after use, and is lower in cost, more energy-saving and more environment-friendly.

Preferably, the side wall of the bottom of the applicator 1 is fixedly provided with a lifting block 7, and the lifting block 7 is convenient for an operator to adjust the position of the applicator 1, so that the applicator 1 is not directly held by hands to operate, and the operation is more convenient.

Example two:

when the tumor 3 types in the body of the patient are more, a plurality of channels can be arranged in the applicator 1, and the insertion needles with various types of channels are inserted into the channels, so that the cervical tumor, the uterine tumor and the vaginal tumor can be treated at the same time, the treatment efficiency is improved, and the treatment cost is reduced.

According to the preferred embodiment provided by the invention, the individualized uterine cavity applicator is set for the patient according to different disease conditions, the individualized uterine cavity applicator is set according to the image data of the patient and the physiological structure of the patient, the number of source channels is large, the matching degree with the tumor structure is high, and the three-dimensional conformal degree is better. Improve the conformality and the receiving capacity of the tumor brachytherapy and reduce the receiving capacity of normal tissues. Improve the local control rate and survival rate of patients and reduce the radiotherapy injury of normal tissues.

Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes in the embodiments and/or modifications of the invention can be made, and equivalents and modifications of some features of the invention without departing from the spirit and scope of the invention.

Claims

3D prints multichannel model of vagina and fills in source applicator, including source applicator (1), its characterized in that: the applicator (1) is formed by 3D printing and is used for accurately matching the vagina (4) of a patient, wherein the end part of the applicator (1) is inserted into the vagina (4) of the patient, a plurality of flexible insertion needles are fixedly arranged at the end part of the applicator (1), and the flexible insertion needles are inserted into the tumor (3) of the patient to carry out radiotherapy and chemotherapy on the patient.
2. The 3D printing vaginal multichannel model plug applicator of claim 1, wherein: the working process of the applicator (1) comprises the following steps:

the method comprises the following steps: collecting patient image data CT and MRI, establishing a patient tumor model, determining the type, position, shape and size of a tumor, and delineating a target area and a low tolerance area;

step two: designing a source distribution channel by combining the medical history of a patient, firstly filling the vagina (2), expanding the vagina of the vagina (2) to a comfortable degree, keeping the same expansion degree among the treatments, and then performing nuclear magnetic resonance to obtain the bending degree of the uterus, the length of the uterine cavity and the length of the vagina so as to determine the design parameters of the source applicator;

step three: designing a source applicator according to a source distribution scheme and patient image data, generally reconstructing a vagina (2) model and a tumor (3) model of a patient according to the data information acquired in the step two, then modeling and setting the source applicator (1) by adopting three-dimensional modeling software to simulate a treatment process, and finally implementing 3D printing, wherein the 3D printed material is a transparent or semitransparent material;

step four: and (3) performing quality inspection and disinfection on the applicator (1).
3. The 3D printing vaginal multichannel model plug applicator of claim 2, wherein: the inserting needle of the source applicator (1) comprises an auxiliary inserting needle (4) and a main inserting needle (5), wherein the end part of the source applicator (1) is provided with four blind holes according to the tumor position of a patient, the auxiliary inserting needle (4) is fixedly arranged in the blind holes, meanwhile, the middle position of the source applicator (1) is provided with a rectangular groove (6), and the main inserting needle (5) is slidably inserted in the rectangular groove (6).
4. The 3D printing vaginal multichannel model plug applicator of claim 2, wherein: solid water is selected as the 3D printing material.
5. The 3D printing vaginal multichannel model plug applicator of claim 2, wherein: and a lifting block (7) is fixedly arranged on the side wall of the bottom of the applicator (1).
6. The 3D printing vaginal multichannel model plug applicator of claim 2, wherein: the target area range is a range area subjected to radioactive source treatment, and the range area is adapted to the diseased range of skin cancer or skin lymphoma on the surface of a patient.
7. The 3D printing vaginal multichannel model plug applicator of claim 2, wherein: the design parameters of the applicator include: size information of the binding surface, thickness information and channel information of the radioactive source.
8. The 3D printing vaginal multichannel model plug applicator of claim 7, wherein: the fitting surface is generally consistent with the body surface of a patient undergoing radioactive source treatment, so that the placing can be kept stable.
9. The 3D printing vaginal multichannel model plug applicator of claim 7, wherein: the thickness information and the radiation source passage information can be set according to the actual condition of the affected area of the patient.
10. The 3D printing vaginal multichannel model plug applicator of claim 2, wherein: a plurality of channels are arranged in the applicator (1), and insertion needles with various types of channels are inserted into the channels.