CN112603911A - Double-layer adhesive film for treating oral ulcer and preparation method thereof - Google Patents
Double-layer adhesive film for treating oral ulcer and preparation method thereof Download PDFInfo
- Publication number
- CN112603911A CN112603911A CN201910883209.XA CN201910883209A CN112603911A CN 112603911 A CN112603911 A CN 112603911A CN 201910883209 A CN201910883209 A CN 201910883209A CN 112603911 A CN112603911 A CN 112603911A
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- chitosan
- layer
- double
- film
- carboxymethyl chitosan
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- 208000007117 Oral Ulcer Diseases 0.000 title claims abstract description 21
- 208000002399 aphthous stomatitis Diseases 0.000 title claims abstract description 21
- 239000002313 adhesive film Substances 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 229920001661 Chitosan Polymers 0.000 claims abstract description 62
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 41
- 239000010410 layer Substances 0.000 claims abstract description 34
- 239000000463 material Substances 0.000 claims abstract description 24
- 239000004814 polyurethane Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 12
- 238000002955 isolation Methods 0.000 claims abstract description 11
- 229920002635 polyurethane Polymers 0.000 claims abstract description 9
- 239000011241 protective layer Substances 0.000 claims abstract description 9
- 239000012790 adhesive layer Substances 0.000 claims abstract description 7
- 239000012528 membrane Substances 0.000 claims abstract description 6
- 239000004925 Acrylic resin Substances 0.000 claims abstract description 5
- 229920000178 Acrylic resin Polymers 0.000 claims abstract description 5
- 239000001856 Ethyl cellulose Substances 0.000 claims abstract description 5
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229920001249 ethyl cellulose Polymers 0.000 claims abstract description 5
- 235000019325 ethyl cellulose Nutrition 0.000 claims abstract description 5
- 239000005714 Chitosan hydrochloride Substances 0.000 claims description 2
- 229940054190 hydroxypropyl chitosan Drugs 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 2
- 208000025865 Ulcer Diseases 0.000 abstract description 18
- 231100000397 ulcer Toxicity 0.000 abstract description 17
- 208000027418 Wounds and injury Diseases 0.000 abstract description 11
- 208000002193 Pain Diseases 0.000 abstract description 8
- 230000035876 healing Effects 0.000 abstract description 2
- 238000000926 separation method Methods 0.000 abstract description 2
- 238000004108 freeze drying Methods 0.000 description 20
- 239000007864 aqueous solution Substances 0.000 description 9
- 206010052428 Wound Diseases 0.000 description 8
- 230000001954 sterilising effect Effects 0.000 description 6
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 238000005520 cutting process Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000004806 packaging method and process Methods 0.000 description 4
- 238000003825 pressing Methods 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 208000020670 canker sore Diseases 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 206010006326 Breath odour Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 210000005178 buccal mucosa Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000010525 oxidative degradation reaction Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000012286 potassium permanganate Substances 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- 210000001584 soft palate Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001720 vestibular Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to the field of medical instruments, and particularly discloses a double-layer adhesive film for treating oral ulcer and a preparation method thereof. The double-layer adhesive film for treating the oral ulcer consists of an adhesive layer and a separation protective layer. Wherein, the main component of the adhesion layer is a water-soluble derivative of chitosan, and the preferable component is carboxymethyl chitosan; the isolation protective layer is made of medical polyurethane material, acrylic resin material and ethyl cellulose membrane material, and preferably is a PU membrane. The dental ulcer paste prepared by the process method has excellent adhesiveness, can promote the healing of ulcer wound surfaces, and can isolate and protect the wound surfaces, thereby playing a role in obviously relieving pain.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a double-layer adhesive film for treating oral ulcer and a preparation method thereof.
Background
Oral ulcer is a common ulcerative injury disease occurring in oral mucosa, and is mostly seen in the inner side of lip, tongue abdomen, buccal mucosa, vestibular sulcus, soft palate and the like. Recurrent oral ulcer is common in daily life, has the appearance of single or multiple round or oval ulcers with different sizes, is covered with a gray or yellow false membrane on the surface, is sunken in the center, has clear boundaries, is red and slightly swollen on peripheral mucous membranes, has the characteristics of periodicity, recurrence and self-limitation, can occur all the year round, and can be self-healed generally for about 10 to 15 days.
Burning pain is a prominent feature of canker sore conditions. The pain is severe when the oral ulcer is attacked, the local burning pain is obvious, the severe patients can influence diet and speaking, and great inconvenience is caused to the daily life of the patients; can be complicated with halitosis, headache, dizziness, nausea, asthenia, dysphoria, fever, and lymphadenectasis.
In order to relieve pain symptoms of patients suffering from oral ulcer, clinicians usually burn local wound surfaces with 10% silver nitrate aqueous solution, or gargle with 0.1% potassium permanganate solution, compound boric acid solution and the like, but the operations are only sterilization treatment on the ulcer wound surfaces, and cannot effectively protect the ulcer wound surfaces, so that the effect of relieving pain is very little. The traditional Chinese medicine for treating oral ulcer is powder, such as Bingpeng powder and the like, and has the defects that the ulcer wound cannot be effectively protected, and patients still have pain during eating, speaking and the like.
A variety of canker sore patches have been introduced on the market, which have been summarized as having the following problems: some adhesive surfaces have low viscosity and are easy to fall off; some materials are hard and do not have good fitting property; some double surfaces are sticky, and are easy to stick to other parts of the oral cavity to fall off; thereby making it difficult to solve the actual problems of the patients with oral ulcer.
Disclosure of Invention
The invention provides a double-layer sticking film for treating oral ulcer and a preparation method thereof. The dental ulcer paste prepared by the process method has excellent adhesiveness, can promote the healing of ulcer wound surfaces, and can isolate and protect the wound surfaces, thereby playing a role in obviously relieving pain.
The core features of the invention are: the double-layer adhesive film for treating the oral ulcer consists of an adhesive layer and a separation protective layer. Wherein the main component of the adhesion layer is a water-soluble derivative of chitosan; the isolation protective layer is made of medical polyurethane material, acrylic resin material and ethyl cellulose membrane material.
The invention relates to a double-layer adhesive film for treating oral ulcer, wherein the main component of an adhesive layer is a water-soluble derivative of chitosan, and the double-layer adhesive film comprises the following components: o-carboxymethyl chitosan, N/O carboxymethyl chitosan, hydroxypropyl chitosan, quaternary ammonium salt of chitosan, chitosan hydrochloride, alkylated chitosan and other water-soluble derivatives of chitosan.
The double-layer adhesive film for treating the dental ulcer, disclosed by the invention, can be used for treating the dental ulcer, wherein the main component of the adhesive layer can be a water-soluble derivative of chitosan or a mixture of a plurality of water-soluble derivatives of chitosan according to any proportion. Wherein the preferred component is carboxymethyl chitosan.
The invention relates to a double-layer film for treating oral ulcer, wherein an isolation protective layer is made of a medical polyurethane material, an acrylic resin material and an ethyl cellulose film material. Among them, a PU film (an inert polyurethane material) is preferable.
The double-layer film for treating the dental ulcer is characterized in that the thickness of the PU film of the isolation and protection layer is preferably 0.025-1.0 mm.
Carboxymethyl chitosan is a product of chitosan after carboxymethylation, is a derivative of chitosan, has excellent water solubility, antibacterial property, biodegradability, biocompatibility, film-forming property, moisture retention and adsorbability, has the function of obviously promoting wound healing, and has been widely accepted and applied in the medical field.
The carboxymethyl chitosan material is used as an adhesive layer, and when the carboxymethyl chitosan material is in contact with a wet ulcer wound surface, the carboxymethyl chitosan material can quickly absorb moisture and tightly adhere to the ulcer surface, so that the carboxymethyl chitosan material can play roles in sterilizing, controlling infection and promoting the ulcer wound surface to quickly heal. Meanwhile, the adhesion layer can also firmly adsorb the isolation protection layer, so that the isolation protection layer is firmly attached to the ulcer surface.
The PU film is an inert polyurethane material, also called medical non-degradable polyurethane material, has the outstanding characteristics of stability, difficult hydrolysis and oxidative degradation, good biological stability, biocompatibility and antibacterial property, good mechanical property, high elasticity, wear resistance and the like, and is widely used for manufacturing medical devices and human organs which are implanted into human bodies for a long time.
The PU film is used as an isolation protective layer, and can be well attached to the ulcer surfaces under various conditions due to the characteristics of softness and excellent ductility, so that the isolation protective layer plays a role in isolating and protecting the ulcer surfaces.
The invention relates to a double-layer sticking film for treating oral ulcer and a preparation method thereof, which are mainly realized by the following technical scheme:
the method comprises the following steps: dissolving a water-soluble derivative of chitosan, preferably carboxymethyl chitosan, in purified water according to the mass percent concentration of 0.5-1.5%, and completely dissolving and uniformly diffusing the chitosan;
step two: pouring the uniformly dissolved and diffused carboxymethyl chitosan aqueous solution into a freeze-drying tray to ensure that the liquid level depth is 5 mm;
step three: placing the freeze-drying tray filled with the carboxymethyl chitosan aqueous solution in a freeze-drying machine, and freeze-drying to prepare carboxymethyl chitosan freeze-drying sponge;
step four: pressing carboxymethyl chitosan sponge into a film shape, wherein the thickness of the carboxymethyl chitosan sponge is controlled to be 0.5-2.0 mm;
step five: sticking a commercially available medical PU film on one surface of the carboxymethyl chitosan film prepared in the step four to obtain a double-layer sticking film;
step six: and cutting the double-layer film obtained in the fifth step into a required shape and size, sealing and packaging, and performing irradiation sterilization to obtain the finished product of the invention.
Detailed Description
The present invention will be described in detail with reference to specific examples, but the embodiments, the use and the purpose of which are illustrated only by way of example, and are not intended to limit the actual scope of the present invention in any way. All other embodiments of the invention as claimed are within the scope of the invention.
Example 1
The invention relates to a double-layer sticking film for treating oral ulcer and a preparation method thereof, wherein the preparation method comprises the following steps:
the method comprises the following steps: dissolving carboxymethyl chitosan in purified water according to the mass percent concentration of 0.5%, and completely dissolving and uniformly diffusing the carboxymethyl chitosan;
step two: pouring the uniformly dissolved and diffused carboxymethyl chitosan aqueous solution into a freeze-drying tray to ensure that the liquid level depth is 5 mm;
step three: placing the freeze-drying tray filled with the carboxymethyl chitosan aqueous solution in a freeze-drying machine, and freeze-drying to prepare carboxymethyl chitosan freeze-drying sponge;
step four: pressing carboxymethyl chitosan sponge into a film shape, wherein the thickness of the carboxymethyl chitosan sponge is controlled to be 0.8 mm;
step five: sticking a commercially available medical PU film on one surface of the carboxymethyl chitosan film prepared in the step four to obtain a double-layer sticking film;
step six: and cutting the double-layer adhesive film obtained in the fifth step into the size of 10 multiplied by 10mm, sealing and packaging, and performing irradiation sterilization to obtain the finished product of the invention.
Example 2
The invention relates to a double-layer sticking film for treating oral ulcer and a preparation method thereof, wherein the preparation method comprises the following steps:
the method comprises the following steps: dissolving carboxymethyl chitosan in purified water according to the mass percent concentration of 1.0%, and completely dissolving and uniformly diffusing the carboxymethyl chitosan;
step two: pouring the uniformly dissolved and diffused carboxymethyl chitosan aqueous solution into a freeze-drying tray to ensure that the liquid level depth is 5 mm;
step three: placing the freeze-drying tray filled with the carboxymethyl chitosan aqueous solution in a freeze-drying machine, and freeze-drying to prepare carboxymethyl chitosan freeze-drying sponge;
step four: pressing carboxymethyl chitosan sponge into a film shape, wherein the thickness of the carboxymethyl chitosan sponge is controlled to be 1.0 mm;
step five: sticking a commercially available medical PU film on one surface of the carboxymethyl chitosan film prepared in the step four to obtain a double-layer sticking film;
step six: and cutting the double-layer adhesive film obtained in the fifth step into the size of 10 multiplied by 20mm, sealing and packaging, and performing irradiation sterilization to obtain the finished product of the invention.
Example 3
The invention relates to a double-layer sticking film for treating oral ulcer and a preparation method thereof, wherein the preparation method comprises the following steps:
the method comprises the following steps: dissolving carboxymethyl chitosan in purified water according to the mass percent concentration of 1.2%, and completely dissolving and uniformly diffusing the carboxymethyl chitosan;
step two: pouring the uniformly dissolved and diffused carboxymethyl chitosan aqueous solution into a freeze-drying tray to ensure that the liquid level depth is 5 mm;
step three: placing the freeze-drying tray filled with the carboxymethyl chitosan aqueous solution in a freeze-drying machine, and freeze-drying to prepare carboxymethyl chitosan freeze-drying sponge;
step four: pressing carboxymethyl chitosan sponge into a film shape, wherein the thickness of the carboxymethyl chitosan sponge is controlled to be 1.0 mm;
step five: sticking a commercially available medical PU film on one surface of the carboxymethyl chitosan film prepared in the step four to obtain a double-layer sticking film;
step six: and cutting the double-layer adhesive film obtained in the fifth step into the size of 20 multiplied by 20mm, sealing and packaging, and performing irradiation sterilization to obtain the finished product of the invention.
The above description is only exemplary of the present invention and should not be taken as limiting the invention, as any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (5)
1. A double-layer sticking film for treating oral ulcer and a preparation method thereof are characterized in that: the double-layer adhesive film for treating the oral ulcer consists of an adhesive layer and an isolation protective layer; wherein the main component of the adhesion layer is a water-soluble derivative of chitosan; the isolation protective layer is made of medical polyurethane material, acrylic resin material and ethyl cellulose membrane material.
2. The method of claim 1, wherein the main component of the adhesion layer is a water-soluble derivative of chitosan comprising: o-carboxymethyl chitosan, N/O carboxymethyl chitosan, hydroxypropyl chitosan, quaternary ammonium salt of chitosan, chitosan hydrochloride, alkylated chitosan and other water-soluble derivatives of chitosan.
3. The method according to claim 2, wherein the main component of the adhesive layer may be a water-soluble derivative of chitosan, or a mixture of water-soluble derivatives of chitosan in any ratio; wherein the preferred component is carboxymethyl chitosan.
4. The method according to claim 1, wherein the isolation and protection layer is made of medical polyurethane material, acrylic resin material or ethyl cellulose membrane material; among them, a PU film (an inert polyurethane material) is preferable.
5. The process according to claim 4, the PU film preferably has a thickness of from 0.025 to 1.0 mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910883209.XA CN112603911A (en) | 2019-09-18 | 2019-09-18 | Double-layer adhesive film for treating oral ulcer and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910883209.XA CN112603911A (en) | 2019-09-18 | 2019-09-18 | Double-layer adhesive film for treating oral ulcer and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112603911A true CN112603911A (en) | 2021-04-06 |
Family
ID=75224248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910883209.XA Pending CN112603911A (en) | 2019-09-18 | 2019-09-18 | Double-layer adhesive film for treating oral ulcer and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112603911A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1954843A (en) * | 2005-10-26 | 2007-05-02 | 天津药物研究院 | Traditional Chinese medicine plaster for treating tunica mucosa oris ulcer and its preparation method |
| CN104856979A (en) * | 2015-06-05 | 2015-08-26 | 黄焱 | Carbenoxolone sodium oral patch, and preparation and application thereof |
| CN106109445A (en) * | 2016-06-22 | 2016-11-16 | 佛山市高明绿化纳新材料有限公司 | A kind of long-acting slow-release film for treating oral ulcer and preparation method thereof |
| CN106138096A (en) * | 2016-07-28 | 2016-11-23 | 山东赛克赛斯药业科技有限公司 | A kind of film for treating oral ulcer and preparation method and application |
| CN108785496A (en) * | 2018-09-03 | 2018-11-13 | 解智强 | A kind of canker sore sustained release pad pasting and preparation method thereof |
-
2019
- 2019-09-18 CN CN201910883209.XA patent/CN112603911A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1954843A (en) * | 2005-10-26 | 2007-05-02 | 天津药物研究院 | Traditional Chinese medicine plaster for treating tunica mucosa oris ulcer and its preparation method |
| CN104856979A (en) * | 2015-06-05 | 2015-08-26 | 黄焱 | Carbenoxolone sodium oral patch, and preparation and application thereof |
| CN106109445A (en) * | 2016-06-22 | 2016-11-16 | 佛山市高明绿化纳新材料有限公司 | A kind of long-acting slow-release film for treating oral ulcer and preparation method thereof |
| CN106138096A (en) * | 2016-07-28 | 2016-11-23 | 山东赛克赛斯药业科技有限公司 | A kind of film for treating oral ulcer and preparation method and application |
| CN108785496A (en) * | 2018-09-03 | 2018-11-13 | 解智强 | A kind of canker sore sustained release pad pasting and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 青岛卫辽生物: "即将上市产品一览", 《微信公众号-青岛卫辽生物》, pages 1 - 3 * |
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Application publication date: 20210406 |
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