CN112599403A - Ion funnel device for mass spectrum ionization source - Google Patents
Ion funnel device for mass spectrum ionization source Download PDFInfo
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- CN112599403A CN112599403A CN202011481404.9A CN202011481404A CN112599403A CN 112599403 A CN112599403 A CN 112599403A CN 202011481404 A CN202011481404 A CN 202011481404A CN 112599403 A CN112599403 A CN 112599403A
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- ion funnel
- pole piece
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- 238000001819 mass spectrum Methods 0.000 title description 4
- 238000004949 mass spectrometry Methods 0.000 claims abstract description 20
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- 229920002530 polyetherether ketone Polymers 0.000 claims abstract description 10
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- 239000002184 metal Substances 0.000 claims description 6
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- 239000000463 material Substances 0.000 claims 1
- 150000002500 ions Chemical class 0.000 abstract description 105
- 230000000694 effects Effects 0.000 abstract description 4
- 238000011982 device technology Methods 0.000 abstract description 3
- 238000000451 chemical ionisation Methods 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010494 dissociation reaction Methods 0.000 description 1
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- 230000004907 flux Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
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- 238000005549 size reduction Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/065—Ion guides having stacked electrodes, e.g. ring stack, plate stack
- H01J49/066—Ion funnels
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
本发明公开了一种用于质谱电离源中的离子漏斗装置，涉及质谱分析仪器。具体结构包括绕中心轴线360°一周带有六根支撑杆的离子漏斗支撑台、离子漏斗极片、绝缘PEEK垫和紧固螺母。离子沿着离子漏斗中心轴线方向由中间口径大的离子漏斗极片入射，并从中间口径小的离子漏斗极片出射，所有离子漏斗极片均中间圆孔的平板结构，并且平行、同轴、绝缘放置。本离子漏斗装置以最小的尺寸设计，目的在于使质谱电离源的结构空间尽量小巧，在保证离子漏斗作用的同时缩减了常规离子漏斗的绝对尺寸。该新型的离子漏斗装置技术大大缩减空间尺寸，并且使用效果与常规离子漏斗装置功能相同，在质谱分析仪器简便化、小巧化结构设计中具有广阔的应用前景。
The invention discloses an ion funnel device used in a mass spectrometry ionization source, and relates to a mass spectrometry instrument. The specific structure includes an ion funnel support table with six support rods around the central axis 360°, an ion funnel pole piece, an insulating PEEK pad and a fastening nut. The ions are incident along the central axis of the ion funnel from the ion funnel pole piece with a large middle diameter, and exit from the ion funnel pole piece with a small middle diameter. Insulated placement. The ion funnel device is designed with the smallest size, aiming at making the structure space of the mass spectrometer ionization source as small as possible, and reducing the absolute size of the conventional ion funnel while ensuring the function of the ion funnel. The new ion funnel device technology greatly reduces the space size, and the use effect is the same as that of the conventional ion funnel device, and has broad application prospects in the simple and compact structure design of mass spectrometry instruments.
Description
Technical Field
The invention belongs to the field of analytical chemical instruments, particularly relates to a mass spectrometry instrument, and particularly relates to an ion funnel device used in a mass spectrometry ionization source.
Background
The mass spectrometer is a chemical analyzer with very high precision, but in order to improve the sensitivity and resolution, the components of the mass spectrometer need to be continuously improved to meet higher requirements. The mass spectrometer mainly ionizes a sample, and the sample can be better analyzed only by a better ionization source, so that the research on the performance of the ionization source of the mass spectrometer is particularly important, and the ion funnel device not only can perform focusing transmission on the sample, but also plays a particularly important role in dissociation analysis of the sample.
The patent No. ZL201711204824.0 discloses a photoionization and chemical ionization combined ion source (patent No. ZL201711204824.0) which comprises a closed chamber, wherein a grid electrode is arranged in the middle of the closed chamber, and the closed chamber is divided into a left independent chamber and a right independent chamber by the grid electrode, namely a photoionization region cavity and a chemical ionization region cavity; ultraviolet light emitted by an ultraviolet light source penetrates through the side wall surface of the photoionization region cavity and is emitted into the region where the ion repulsion electrode and the grid electrode are spaced from each other along the surface parallel to the grid electrode; an ion funnel reaction area electrode is arranged in the chemical ionization area cavity. The combined ion source is based on a single ultraviolet light source, reagent ions for chemical ionization are obtained by utilizing photoionization or photoelectron ionization, and relatively independent ionization region design is adopted, so that mutual interference between photoionization and chemical ionization is avoided, photoionization or chemical ionization of sample molecules is respectively realized, and the range of ionizable and detected samples is greatly widened.
An ion funnel and mass spectrometry detection system (patent number zl201610023503.x) invented by schlieren et al, comprising M ring electrodes with same outer diameter and coaxial equal spacing arrangement, the inner diameter of which is reduced from the 1 st ring electrode to the M ring electrode in turn, the ion funnel further comprising: the first direct current power supply and the second direct current power supply, the first radio frequency power supply to the Nth radio frequency power supply; the first direct current power supply and the second direct current power supply are respectively connected to the first annular electrode and the Mth annular electrode and connect the M electrodes in series through a divider resistor; the first radio frequency power supply is connected with the 1 st, 1+ N and 1+2N … … th annular electrodes in parallel; the second radio frequency power supply is connected with the 2 nd, the 2 nd + N and the 2+2N … … th annular electrodes in parallel; … …, respectively; the (N-1) radio frequency power supply is connected with the (N-1) th, the (N-1 + N) th and the (N-1 +2N … …) th annular electrodes in parallel; the Nth radio frequency power supply is connected with the Nth, the Nth + N and the N +2N … … th ring electrodes in parallel. The invention improves the transmission efficiency of ions, in particular to the transmission efficiency of ions with small mass number.
The invention discloses an ultraviolet light chemical ionization source based on an ion funnel (patent number ZL201611019684.5) invented by Lihai et al, which comprises an ionization source cavity, a vacuum ultraviolet lamp, an excitation electrode, a reagent gas sample inlet pipe, a repulsion electrode, a sample gas sample inlet pipe, an ion funnel and a differential electrode. The ionization source utilizes the excellent focusing performance of the ion funnel under the medium air pressure, improves the reaction sufficiency of reagent ions and sample molecules and the transmission efficiency of the sample ions, realizes the enhancement of the ionization efficiency of the vacuum ultraviolet photochemical ionization source, and can greatly improve the sensitivity of the instrument.
A vacuum ultraviolet light ionization source for high flux gas sample analysis invented by plum sea et al (patent number ZL201010567335.3), comprising an ionization source cavity and a vacuum ultraviolet light source; a gas inlet is formed in the top of the ionization source cavity, and a gas sample enters the ionization source cavity through the gas inlet; an ion extraction electrode, an ion funnel and a differential interface polar plate which are mutually spaced, coaxial and parallel are sequentially arranged in the ionization source cavity along the flowing direction of the gas sample; the vacuum ultraviolet light source is arranged on the side wall of the ionization source cavity, and the vacuum ultraviolet light emitted by the vacuum ultraviolet light source is parallel to the polar plates of the ion extraction electrode and penetrates through the mutually spaced regions between the polar plates to enter the through hole region of the ion extraction polar plate. The vacuum ultraviolet light ionization source can effectively improve the detection sensitivity of the whole mass spectrometer system, and has wide application prospect in the fields of high-throughput gas sample analysis and trace or ultra-trace detection of organic pollutants in the environment.
While the above patents concerning ion funnels have advantages, they are bulky, have numerous mounting parts, are complex to install, and require excessive adjustment to ensure proper alignment. Aiming at the problems of simplified and light structure, simple and concise installation and size reduction of an ionization source of a mass spectrometer, the invention ensures that the structural space of the mass spectrometer ionization source is small as possible, and simultaneously reduces the absolute size of a conventional ion funnel. The novel ion funnel device technology greatly reduces the space size, has the same function as a conventional ion funnel device in the using effect, and has wide application prospect in the simple and convenient and small structural design of a mass spectrometry instrument.
Disclosure of Invention
The invention provides an ion funnel device used in a mass spectrum ionization source, which comprises an ion funnel support table, an ion funnel pole piece, an insulating PEEK pad and a fastening nut, wherein the ion funnel support table is provided with six support rods around the central axis in a circle of 360 degrees. Ions are incident from the ion funnel pole piece with a large middle caliber along the central axis direction of the ion funnel and are emergent from the ion funnel pole piece with a small middle caliber, and all the ion funnel pole pieces are of a flat plate structure with a middle round hole and are placed in parallel, coaxially and in an insulating mode.
An ion funnel device for a mass spectrometry ionization source comprises an ion funnel supporting table with six supporting rods around the central axis for 360 degrees, wherein an ion funnel pole piece is sleeved in the six supporting rods on the ion funnel supporting table, the ion funnel pole piece is divided into three supporting arms around the central axis for 360 degrees by 120 degrees, each supporting arm is provided with a hole, and the three holes are sleeved in the three supporting rods on the six supporting rods on the ion funnel supporting table. The adjacent ion funnel pole pieces are separated by the insulation PEEK pad to ensure that the adjacent ion funnel pole pieces are placed in an insulation manner, and finally, the whole ion funnel pole pieces are fastened by the fastening nuts.
Furthermore, adjacent ion funnel pole pieces are sleeved into six support rods on the ion funnel support platform in a staggered mode, the ion funnel pole pieces and the ion funnel support platform are both of a structure with a through hole in the middle, and the ion funnel pole pieces and the ion funnel support platform are parallel, insulated and coaxially arranged.
Furthermore, the ion funnel pole piece is made of metal such as stainless steel or the like or a pole piece with a metal plated on the surface; the number of the pole pieces of the ion funnel pole piece is 18 or more than 18 even pole pieces; the aperture of the through hole of the ion funnel pole piece is 1-30 mm.
Further, uniform voltage along the axial direction is applied to the ion funnel pole pieces in sequence from high to low, and a transmission electric field with the size of 5-50V/cm is formed in the axial direction. Meanwhile, radio frequency voltages with different positive and negative and the same size are applied between the adjacent ion funnel pole pieces.
Furthermore, the vacuum degree of the ion funnel pole piece is maintained between 1Torr and 5 Torr.
Furthermore, the adjacent ion funnel pole pieces are separated by an insulating PEEK pad, and the diameter of a middle through hole of the insulating PEEK pad is the same as that of a support rod on the ion funnel support platform.
Furthermore, the middle through holes of the ion funnel pole pieces are sequentially reduced from large to small according to a certain rule, and funnel shapes are formed on the premise of ensuring coaxiality.
Has the advantages that: the ion funnel device is designed with the minimum size, aims to enable the structural space of a mass spectrum ionization source to be small and exquisite as much as possible, and reduces the absolute size of a conventional ion funnel while ensuring the effect of the ion funnel. The novel ion funnel device technology greatly reduces the space size, has the same function as a conventional ion funnel device in the using effect, and has wide application prospect in the simple and convenient and small structural design of a mass spectrometry instrument.
Drawings
FIG. 1 is a schematic diagram of an ion funnel apparatus for use in a mass spectrometry ionization source;
FIG. 2 is a schematic view of an ion funnel support table of an ion funnel apparatus for use in a mass spectrometry ionization source;
FIG. 3 is a schematic diagram of an ion funnel pole piece of an ion funnel device for use in a mass spectrometry ionization source.
In the figure: 1. ion funnel pole piece, 2, fastening nut, 3, insulating PEEK pad, 4, ion funnel brace table, 1.1, hole, 1.2, support arm, 1.3, through-hole, 4.1, bracing piece.
Detailed Description
The following non-limiting examples will allow one of ordinary skill in the art to more fully understand the present invention, but are not intended to limit the invention in any way.
As shown in fig. 1, 2 and 3, an ion funnel device for use in a mass spectrometry ionization source comprises an ion funnel support platform 4 with six support rods 4.1 surrounding a central axis for 360 degrees, an ion funnel pole piece 1 is sleeved in the six support rods 4.1 on the ion funnel support platform 4, the ion funnel pole piece 1 is divided into three support arms 1.2 surrounding the central axis for 360 degrees by 120 degrees, each support arm 1.2 is provided with a hole 1.1, and the three holes 1.1 are sleeved in three non-adjacent support rods on the six support rods 4.1 on the ion funnel support platform 4; adjacent ion funnel pole piece 1 is separated mutually by insulating PEEK pad 3 to guarantee insulating the placing between adjacent ion funnel pole piece 1, fasten whole ion funnel pole piece 1 by fastening nut 2 at last.
In the six spinal branch vaulting poles 4.1 on the ion funnel brace table 4 were emboliaed with crisscross mode to adjacent ion funnel pole piece 1, ion funnel pole piece 1 and ion funnel brace table 4 are the structure that the middle part was provided with through-hole 1.3 to be parallel, insulating, coaxial placing between ion funnel pole piece 1 and the ion funnel brace table 4.
The ion funnel pole piece 1 is made of metal or a pole piece with a metal plated surface; the number of the ion funnel pole pieces 1 is 18 or more than 18 even pole pieces; the aperture of the through hole 1.3 of the ion funnel pole piece 1 is 1-30 mm.
Applying uniform voltage along the axial direction on the ion funnel pole piece 1 according to the pole piece sequence from high to low, and forming a transmission electric field with the size of 5-50V/cm in the axial direction; meanwhile, radio frequency voltages which are different in positive and negative and same in size are applied between the adjacent ion funnel pole pieces 1.
The vacuum degree of the ion funnel pole piece 1 is maintained between 1Torr and 5 Torr.
The diameter of the middle through hole of the insulation PEEK pad 3 is the same as that of the support rod 4.1 on the ion funnel support platform 4.
The middle through hole 1.3 of the ion funnel pole piece 1 is reduced from large to small in sequence, and funnel shape is formed on the premise of ensuring coaxiality.
Claims (7)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011481404.9A CN112599403A (en) | 2020-12-15 | 2020-12-15 | Ion funnel device for mass spectrum ionization source |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011481404.9A CN112599403A (en) | 2020-12-15 | 2020-12-15 | Ion funnel device for mass spectrum ionization source |
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| Publication Number | Publication Date |
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| CN112599403A true CN112599403A (en) | 2021-04-02 |
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| CN202011481404.9A Pending CN112599403A (en) | 2020-12-15 | 2020-12-15 | Ion funnel device for mass spectrum ionization source |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113471054A (en) * | 2021-06-02 | 2021-10-01 | 中国科学院化学研究所 | Gridless ion funnel trap device and method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108091539A (en) * | 2016-11-21 | 2018-05-29 | 中国科学院大连化学物理研究所 | A kind of ultraviolet light chemical ionization source based on ion funnel |
| CN207542195U (en) * | 2017-11-21 | 2018-06-26 | 中国科学院大连化学物理研究所 | A kind of spindle ion funnel |
| EP3550587A1 (en) * | 2018-04-05 | 2019-10-09 | Technische Universität München | Partly sealed ion guide and ion beam deposition system |
-
2020
- 2020-12-15 CN CN202011481404.9A patent/CN112599403A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108091539A (en) * | 2016-11-21 | 2018-05-29 | 中国科学院大连化学物理研究所 | A kind of ultraviolet light chemical ionization source based on ion funnel |
| CN207542195U (en) * | 2017-11-21 | 2018-06-26 | 中国科学院大连化学物理研究所 | A kind of spindle ion funnel |
| EP3550587A1 (en) * | 2018-04-05 | 2019-10-09 | Technische Universität München | Partly sealed ion guide and ion beam deposition system |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113471054A (en) * | 2021-06-02 | 2021-10-01 | 中国科学院化学研究所 | Gridless ion funnel trap device and method and application thereof |
| CN113471054B (en) * | 2021-06-02 | 2022-08-30 | 中国科学院化学研究所 | Gridless ion funnel trap device and method and application thereof |
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