CN112553071A - Cell modulation and virus analysis dual-purpose workstation - Google Patents
Cell modulation and virus analysis dual-purpose workstation Download PDFInfo
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- CN112553071A CN112553071A CN202011402592.1A CN202011402592A CN112553071A CN 112553071 A CN112553071 A CN 112553071A CN 202011402592 A CN202011402592 A CN 202011402592A CN 112553071 A CN112553071 A CN 112553071A
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- operation station
- pressure
- air inlet
- fan
- station
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/26—Conditioning fluids entering or exiting the reaction vessel
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04D—NON-POSITIVE-DISPLACEMENT PUMPS
- F04D27/00—Control, e.g. regulation, of pumps, pumping installations or pumping systems specially adapted for elastic fluids
- F04D27/004—Control, e.g. regulation, of pumps, pumping installations or pumping systems specially adapted for elastic fluids by varying driving speed
Abstract
The invention discloses a cell modulation and virus analysis dual-purpose workstation, which comprises: the air conditioner comprises an operation station, a transfer cabin I and a transfer cabin II, wherein the operation station is connected with an operation station exhaust fan and an operation station air inlet fan, the transfer cabin I is connected with a transfer cabin I exhaust fan and a transfer cabin I air inlet fan, and the transfer cabin II is connected with a transfer cabin II exhaust fan and a transfer cabin II air inlet fan. The workstation can ensure positive pressure operation of cells during modulation, so that the probability that the cells are infected can be effectively avoided, and the risk of virus leakage is effectively controlled by negative pressure operation during virus analysis.
Description
Technical Field
The invention relates to the technical field of cell modulation, in particular to a cell modulation and virus analysis dual-purpose workstation.
Background
The two-purpose workstation for cell modulation and virus analysis is an intelligent system which can be used for cell preparation and virus analysis research. Integrates cell culture, virus operation research and observation, and provides one-stop service for cell preparation and virus research. The existing cell workstation only has a single working mode at present, and cannot meet the switching work of cell modulation and virus manufacturing research, so that the use effect and the utilization rate of equipment are influenced.
Disclosure of Invention
According to the problems in the prior art, the invention discloses a cell modulation and virus analysis dual-purpose workstation which comprises an operation station, a transfer cabin I and a transfer cabin II, wherein the operation station is connected with an operation station exhaust fan and an operation station air inlet fan;
before or during work, the work station sets a cell modulation work mode to be 0Pa-80Pa and a virus analysis work mode to be-80 Pa-0Pa according to requirements, and sets the work modes of a transfer cabin I and a transfer cabin II of the operation station independently;
setting a pressure Pre in the operation station, setting a cell modulation mode operation pressure PSTP and a virus analysis mode operation pressure PSTN; setting a cell modulation working mode, carrying out PID calculation on an exhaust fan of the operation station according to a set exhaust pressure parameter value PD to regulate and control the rotating speed of the exhaust fan, and further controlling the exhaust volume of the operation station; the air inlet fan of the operation station automatically performs PID calculation according to the operation pressure PSTP to control the rotating speed of the air inlet fan and further control the pressure in the work station to be positive pressure;
setting a virus analysis working mode, carrying out PID calculation on an air inlet fan of the operation station according to a set air inlet pressure parameter value PD to regulate and control the rotating speed of the air inlet fan, and further controlling the air displacement of the operation station; and the exhaust fan of the operation station automatically performs PID calculation according to the operation pressure PSTN to regulate and control the rotating speed of the fan, so that the pressure in the work station is controlled to be negative pressure.
Further, setting the exhaust pressure PSTE and the intake pressure PSTI of the work station; setting a cell modulation mode operating pressure PSTP; setting a virus analysis mode operation pressure PSTN; the operation station pressure PRE _ WS, the exhaust pressure PREE _ WS and the intake pressure PREI _ WS;
when the work station enters a working state, a working mode is set, and when the cell modulation working mode is set, the exhaust fan of the operation station automatically runs, PID calculation is carried out according to the exhaust pressure PREE _ WS of the operation station to regulate and control the rotating speed of the exhaust fan of the operation station, so that the exhaust pressure PREE _ WS of the operation station is stabilized at the set exhaust pressure PSTE of the operation station to achieve stable exhaust volume.
Further, the operation station air inlet fan automatically runs, PID calculation is carried out according to the operation station pressure PRE _ WS, the rotating speed of the operation station air inlet fan is regulated and controlled, the operation station pressure PRE _ WS is stabilized at the set cell modulation mode operation pressure PSTP to achieve stable ventilation volume, the transfer cabin I and the transfer cabin II are both in the control mode of the set cell modulation mode operation pressure PSTP, and the control methods of the transfer cabin I exhaust fan, the transfer cabin I air inlet fan, the transfer cabin II exhaust fan and the transfer cabin II air inlet fan are the same as the control schemes of the operation station exhaust fan and the operation station air inlet fan.
Further, when a virus analysis working mode is set, the air inlet fan of the operation station automatically operates, PID calculation is carried out according to the air inlet pressure PREI _ WS of the operation station, the rotating speed of the air inlet fan of the operation station is regulated and controlled, and the air inlet pressure PREI _ WS of the operation station is stabilized at the set air inlet pressure PSTI of the operation station so as to achieve stable air inlet volume.
Further, the exhaust fan of the operation station automatically operates, PID calculation is carried out according to the pressure PRE _ WS of the operation station, the rotating speed of the exhaust fan of the operation station is regulated and controlled, and the pressure PRE _ WS of the operation station is stabilized at the operation pressure PSTN in the set virus analysis mode so as to achieve stable ventilation volume; at the moment, the transfer cabin I and the transfer cabin II can also set a cell modulation working mode and a virus analysis working mode, and the control methods of the exhaust fan of the transfer cabin I, the air inlet fan of the transfer cabin I, the exhaust fan of the transfer cabin II and the air inlet fan of the transfer cabin II are the same as the control schemes of the exhaust fan of the operation station and the air inlet fan of the operation station.
Due to the adoption of the technical scheme, the two-purpose workstation for seed cell modulation and virus analysis is provided by the invention. The workstation can ensure positive pressure operation of cells during modulation, so that the probability that the cells are infected can be effectively avoided, and the risk of virus leakage is effectively controlled by negative pressure operation during virus analysis.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments described in the present application, and other drawings can be obtained by those skilled in the art without creative efforts.
FIG. 1 is a block diagram of a dual-purpose workstation for cell modulation and virus analysis according to the present invention.
FIG. 2 is a schematic diagram of the operation of the workstation of the present invention;
FIG. 3 is a schematic diagram of the operation of the workstation of the present invention;
FIG. 4 is a schematic diagram of the operation of the workstation of the present invention;
fig. 5 is a schematic diagram of the operation of the workstation of the present invention.
1. The system comprises an operation station air inlet fan 2, an operation station air outlet fan 3, an operation station 4, a transfer cabin I air inlet fan 5, a transfer cabin I exhaust fan 6, transfer cabins I and 7, a transfer cabin II air inlet fan 8, a transfer cabin II exhaust fan 9 and a transfer cabin II.
Detailed Description
In order to make the technical solutions and advantages of the present invention clearer, the following describes the technical solutions in the embodiments of the present invention clearly and completely with reference to the drawings in the embodiments of the present invention:
a dual-purpose workstation for cell modulation and virus analysis as shown in figure 1 comprises: the device comprises an operation station 3, a transfer cabin I6 and a transfer cabin II9, wherein the operation station 3 is connected with an operation station exhaust fan 2 and an operation station air inlet fan 1, and the transfer cabin I6 is connected with a transfer cabin I exhaust fan 5 and a transfer cabin I air inlet fan 4. And the delivery cabin II9 is connected with a delivery cabin II exhaust fan 8 and a delivery cabin II air inlet fan 7. Before or during the work of the workstation, the cell modulation work mode of 0Pa to 80Pa and the virus analysis work mode of-80 Pa to 0Pa can be set according to requirements, and simultaneously, the work modes of the operation station 3, the transfer cabin I6 and the transfer cabin II9 can also be set independently.
Further, a cell modulation mode is set, and the operation mode is a positive pressure operation mode, and the operation station 3 automatically recognizes the cell modulation mode operation pressure PSTP. At the moment, the exhaust fan 2 of the operation station automatically operates and performs PID calculation and regulation to control the rotating speed of the fan according to the set exhaust pressure, the intake fan 1 of the operation station automatically operates and performs PID calculation and regulation to control the rotating speed of the fan according to PSTP, and then the pressure in the operation station 3 is controlled to be positive pressure and the exhaust air volume is accurately controlled.
Further, a virus analysis mode is set, the operation mode is a negative pressure operation mode, and the operation station 3 automatically recognizes the cell modulation mode operation pressure PSTN. At the moment, the air inlet fan 1 of the operation station automatically operates and performs PID calculation and regulation to control the rotating speed of the fan according to the set air exhaust pressure, the air outlet fan 2 of the operation station automatically operates and performs PID calculation and regulation to control the rotating speed of the fan according to the PSTN, and then the pressure in the operation station 3 is controlled to be negative pressure and the air exhaust amount is accurately controlled.
Further, a workstation exhaust pressure PSTE, a workstation intake pressure PSTI, a cell modulation mode operation pressure PSTP, a virus analysis mode operation pressure PSTN, an operator station pressure PRE _ WS, an operator station exhaust pressure PREE _ WS, and an operator station intake pressure PREI _ WS are set. After the workstation enters the working state, a working mode is set, when the cell modulation working mode is set, the operator station exhaust fan 2 automatically runs and performs PID calculation according to the operator station exhaust pressure PREE _ WS to regulate and control the rotating speed of the operator station exhaust fan 2, so that the operator station exhaust pressure PREE _ WS is stabilized at the set operator station exhaust pressure PSTE to achieve a stable exhaust volume, as shown in FIG. 2.
The operation station air inlet fan 1 automatically operates and performs PID calculation according to the operation station pressure PRE _ WS to adjust and control the rotation speed of the operation station air inlet fan 1, so that the operation station pressure PRE _ WS is stabilized at the set cell modulation mode operation pressure PSTP to achieve stable ventilation volume, as shown in fig. 3.
At the moment, the transfer chamber I6 and the transfer chamber II9 are both in a control mode for setting the cell modulation mode operation pressure PSTP, and the control methods of the exhaust fan 5 and the air inlet fan 4 of the transfer chamber I, the exhaust fan 8 of the transfer chamber II and the air inlet fan 7 of the transfer chamber II are the same as the control schemes of the exhaust fan 2 of the operation station and the air inlet fan 1 of the operation station.
When the virus analysis working mode is set, the operation station air inlet fan 1 automatically operates and performs PID calculation according to the operation station air inlet pressure PREI _ WS to adjust and control the rotating speed of the operation station air inlet fan 1, so that the operation station air inlet pressure PREI _ WS is stabilized at the set work station air inlet pressure PSTI to achieve a stable air inlet volume, as shown in fig. 4.
The operator station exhaust fan 2 automatically operates and performs PID calculation according to the operator station pressure PRE _ WS to adjust and control the rotation speed of the operator station exhaust fan 2, so that the operator station pressure PRE _ WS is stabilized at the set virus analysis mode operation pressure PSTN to achieve stable ventilation volume, as shown in fig. 5.
At this time, the cell modulation working mode and the virus analysis working mode can be set for both the transfer cabin I6 and the transfer cabin II9, and the control methods of the exhaust fan 5 and the air inlet fan 4 of the transfer cabin I, the exhaust fan 8 of the transfer cabin II and the air inlet fan 7 of the transfer cabin II are the same as the control schemes of the exhaust fan 2 of the operation station and the air inlet fan 1 of the operation station.
Due to the adoption of the technical scheme, the cell modulation and virus analysis dual-purpose workstation provided by the invention has the advantages that positive pressure operation is carried out during cell modulation, the probability of cell infection is effectively avoided, and negative pressure operation is carried out during virus analysis, so that the risk of virus leakage is effectively controlled.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (5)
1. A dual-purpose workstation for cell modulation and virus analysis, comprising: the system comprises an operation station (3), a transfer cabin I (6) and a transfer cabin II (9), wherein the operation station (3) is connected with an operation station exhaust fan (2) and an operation station air inlet fan (1), the transfer cabin I (6) is connected with a transfer cabin I exhaust fan (5) and a transfer cabin I air inlet fan (4), and the transfer cabin II (9) is connected with a transfer cabin II exhaust fan (8) and a transfer cabin II air inlet fan (7);
before or during work, the work station sets a cell modulation work mode to be 0Pa-80Pa and a virus analysis work mode to be-80 Pa-0Pa according to requirements, and sets the work modes of a transfer cabin I (6) and a transfer cabin II (9) of the operation station (3) independently;
setting a pressure Pre in the operation station (3), setting a cell modulation mode operation pressure PSTP, a virus analysis mode operation pressure PSTN; setting a cell modulation working mode, carrying out PID calculation on an exhaust fan (2) of the operation station according to a set exhaust pressure parameter value PD to regulate and control the rotating speed of the exhaust fan, and further controlling the exhaust volume of the operation station; the operating station air inlet fan (1) automatically performs PID calculation according to the operating pressure PSTP to control the rotating speed of the air inlet fan and further control the pressure in the workstation (3) to be positive pressure;
setting a virus analysis working mode, carrying out PID calculation on an air inlet fan (1) of the operation station according to a set air inlet pressure parameter value PD to control the rotating speed of the air inlet fan, and further controlling the air displacement of the operation station; the exhaust fan (2) of the operation station automatically performs PID calculation according to the operation pressure PSTN to adjust and control the rotating speed of the fan, and further controls the pressure in the work station (3) to be negative pressure.
2. The dual-purpose workstation for cell modulation and virus analysis according to claim 1, wherein: setting the exhaust pressure PSTE and the intake pressure PSTI of the workstation; setting a cell modulation mode operating pressure PSTP; setting a virus analysis mode operation pressure PSTN; the pressure PRE _ WS, the exhaust pressure PREE _ WS and the intake pressure PREI _ WS of the operation station (3);
when the work station enters a working state, a working mode is set, and when the cell modulation working mode is set, the operation station exhaust fan (2) automatically runs and performs PID calculation according to the operation station exhaust pressure PREE _ WS to regulate and control the rotating speed of the operation station exhaust fan (2), so that the operation station exhaust pressure PREE _ WS is stabilized at the set operation station exhaust pressure PSTE to achieve a stable exhaust volume.
3. The dual-purpose workstation for cell modulation and virus analysis according to claim 2, wherein: the control method of the air inlet fan (1) of the operation station is the same as the control schemes of the air outlet fan (2) of the operation station and the air inlet fan (1) of the operation station, and the control schemes of the air inlet fan (1) of the operation station are the same as the control schemes of the air outlet fan (2) of the operation station and the air inlet fan (1) of the operation station.
4. The dual-purpose workstation for cell modulation and virus analysis according to claim 2, wherein: when a virus analysis working mode is set, the air inlet fan (1) of the operation station automatically operates, PID calculation is carried out according to the air inlet pressure PREI _ WS of the operation station to regulate and control the rotating speed of the air inlet fan (1) of the operation station, and the air inlet pressure PREI _ WS of the operation station is stabilized at the air inlet pressure PSTI of the set operation station so as to achieve stable air inlet amount.
5. The dual-purpose workstation for cell modulation and virus analysis according to claim 2, wherein: the operation station exhaust fan (2) automatically operates and performs PID calculation according to the operation station pressure PRE _ WS to regulate and control the rotating speed of the operation station exhaust fan (2), so that the operation station pressure PRE _ WS is stabilized at the operation pressure PSTN in the set virus analysis mode to achieve stable ventilation volume; at the moment, the transfer cabin I (6) and the transfer cabin II (9) can also set a cell modulation working mode and a virus analysis working mode, and the control methods of the exhaust fan (5) of the transfer cabin I, the air inlet fan (4) of the transfer cabin I, the exhaust fan (8) of the transfer cabin II and the air inlet fan (7) of the transfer cabin II are the same as the control schemes of the exhaust fan (2) of the operation station and the air inlet fan (1) of the operation station.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011402592.1A CN112553071A (en) | 2020-12-02 | 2020-12-02 | Cell modulation and virus analysis dual-purpose workstation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011402592.1A CN112553071A (en) | 2020-12-02 | 2020-12-02 | Cell modulation and virus analysis dual-purpose workstation |
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| CN112553071A true CN112553071A (en) | 2021-03-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202011402592.1A Pending CN112553071A (en) | 2020-12-02 | 2020-12-02 | Cell modulation and virus analysis dual-purpose workstation |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103041417A (en) * | 2013-01-30 | 2013-04-17 | 杭州盈天科学仪器有限公司 | Transfer cabin with sterilization function |
| US20150113927A1 (en) * | 2012-06-11 | 2015-04-30 | Bioquell Uk Limited | Aseptic processing workstation |
| CN104893951A (en) * | 2014-03-03 | 2015-09-09 | 北京双诚联盈净化工程技术有限公司 | Combination of polymerase chain reaction workstation |
| KR101903549B1 (en) * | 2017-05-19 | 2018-10-02 | 삼에이치텍 주식회사 | Energy Saving System using Control of Exhaust Air Amount and Controlling Air Inflow Rate of Inflow Air Speed Control of Multi - Fume Hood |
-
2020
- 2020-12-02 CN CN202011402592.1A patent/CN112553071A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150113927A1 (en) * | 2012-06-11 | 2015-04-30 | Bioquell Uk Limited | Aseptic processing workstation |
| CN103041417A (en) * | 2013-01-30 | 2013-04-17 | 杭州盈天科学仪器有限公司 | Transfer cabin with sterilization function |
| CN104893951A (en) * | 2014-03-03 | 2015-09-09 | 北京双诚联盈净化工程技术有限公司 | Combination of polymerase chain reaction workstation |
| KR101903549B1 (en) * | 2017-05-19 | 2018-10-02 | 삼에이치텍 주식회사 | Energy Saving System using Control of Exhaust Air Amount and Controlling Air Inflow Rate of Inflow Air Speed Control of Multi - Fume Hood |
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