CN112546456A - Control system for neutron capture therapy and method of use thereof - Google Patents
Control system for neutron capture therapy and method of use thereof Download PDFInfo
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- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
- A61N5/1069—Target adjustment, e.g. moving the patient support
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- A61N5/103—Treatment planning systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/109—Neutrons
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Abstract
A control system and method of use thereof for controlling a neutron capture therapy device, the neutron capture therapy device including a table for carrying a patient, the control system comprising: the irradiation parameter selection device is used for selecting the best practicable irradiation point and irradiation angle; a conversion unit for converting parameters of an optimum irradiation point and an optimum irradiation angle that can be implemented into coordinate parameters of the mounting table; and an adjusting section for adjusting the mounting table to the coordinate position obtained from the converting section.
Description
Technical Field
The present invention relates to a control system and a method of using the same, and more particularly, to a control system for neutron capture therapy and a method of using the same.
Background
With the development of atomic science, radiation therapy such as cobalt sixty, linacs, electron beams, etc. has become one of the main means of cancer treatment. However, the traditional photon or electron therapy is limited by the physical conditions of the radiation, and can kill tumor cells and damage a large amount of normal tissues in the beam path; in addition, due to the difference in the sensitivity of tumor cells to radiation, conventional radiotherapy is often ineffective in treating malignant tumors with relatively high radiation resistance, such as multiple glioblastoma multiforme (glioblastoma multiforme) and melanoma (melanoma).
In order to reduce the radiation damage of normal tissues around tumor, the target therapy concept in chemotherapy (chemotherapy) is applied to radiotherapy; for tumor cells with high radiation resistance, radiation sources with high Relative Biological Effect (RBE) are also actively developed, such as proton therapy, heavy particle therapy, neutron capture therapy, etc. The Neutron Capture Therapy combines the two concepts, such as Boron Neutron Capture Therapy (BNCT), and provides a better cancer treatment option than conventional radiation by specific accumulation of Boron-containing drugs in tumor cells in combination with precise beam modulation.
Boron neutron capture therapy utilizing boron-containing (10B) The medicine has the characteristic of high capture cross section for thermal neutrons10B(n,α)7Li neutron capture and nuclear fission reaction generation4He and7the total range of the two heavily charged particles is about equal to one cell size, so that the radiation damage to organisms can be limited to the cell level, and when boron-containing drugs selectively gather in tumor cells and are matched with a proper neutron source, the aim of locally killing the tumor cells can be achieved on the premise of not causing too much damage to normal tissues.
Before the sub-trapping treatment is performed, it is necessary to find an optimum practicable irradiation point and an irradiation angle of the beam, and then move the table on which the patient is placed into the irradiation chamber to adjust the position until the table and the patient are positioned so that the beam can be irradiated at the optimum practicable irradiation point and the optimum implementable irradiation angle which have been found in advance. The process is more complicated and time-consuming, the use efficiency of the neutron capture treatment equipment is reduced, and meanwhile, the long-time continuous adjustment and the positioning are difficult for patients to bear and the operators are tired. In order to reduce the positioning time and improve the use efficiency of the equipment, the positioning process of the placing table needs to be further optimized.
Therefore, it is necessary to provide a method for quickly adjusting the mounting table.
Disclosure of Invention
To overcome the disadvantages of the prior art, the present inventors provide a control system and method of using the same that enables quick adjustment of a table in place.
The present application provides a control system for controlling a neutron capture therapy device, the neutron capture therapy device comprising a table for carrying a patient, the control system comprising: the irradiation parameter selection device is used for selecting the best practicable irradiation point and irradiation angle; a conversion unit for converting parameters of an optimum irradiation point and an irradiation angle that can be implemented into coordinate parameters for which the stage needs to be moved in place; and an adjusting section for adjusting the mounting table to the coordinate position obtained from the converting section.
Further, the irradiation parameter selection device includes a sampling unit that selects a plurality of sets of irradiation points and irradiation angles, a calculation unit that calculates evaluation values corresponding to the irradiation points and the irradiation angles, and a preference unit that selects an optimal set of irradiation points and irradiation angles among all the sampled irradiation points and irradiation angles according to the evaluation values calculated by the calculation unit.
Further, the conversion unit converts parameters of an optimum irradiation point and an optimum irradiation angle that can be implemented into coordinate parameters for which the table needs to be moved in place during irradiation, in combination with CT/MRI/PET-CT information, positioning information, table configuration information, and the like of the patient.
The application also provides a using method of the control system, which comprises the following steps: the irradiation parameter selection device selects the best practical irradiation point and irradiation angle; the conversion part converts the parameters of the best irradiation point and the irradiation angle which can be implemented into the coordinate parameters of the loading platform which needs to be moved in place; the adjusting unit adjusts the mounting table to the coordinate position obtained from the converting unit.
Further, the irradiation parameter selection device comprises a sampling part, a calculation part and a preference part, and the use method of the irradiation parameter selection device is as follows: first, the sampling unit selects a plurality of sets of irradiation points and irradiation angles, the calculation unit calculates evaluation values corresponding to the irradiation points and the irradiation angles for each set, and the selection unit selects an optimum set of practicable irradiation points and irradiation angles among all the sampled irradiation points and irradiation angles based on the evaluation values calculated by the calculation unit.
Furthermore, the neutron capture treatment equipment adopts neutron beams to irradiate a patient to realize treatment, the sampling part reads images with clear human anatomy such as CT/MRI/PET-CT of the patient, the outlines of organs, tissues and tumors are defined one by one, the set material types and densities are given, and after the outlines, the material types and the densities are defined, irradiation points and irradiation angles of a plurality of groups of neutron beams are selected.
Further, the calculation unit calculates a trajectory of an organ of the patient through which the neutron beam passes, that is, calculates the type and thickness of the organ through which the neutron beam passes after entering the human body, determines whether the tumor falls within a maximum treatable depth range after acquiring trajectory information of the neutron beam passing through the human body, and calculates an evaluation value corresponding to the irradiation point and the irradiation angle based on the trajectory information in combination with information, such as boron-containing concentration of the organ, an organ radiation sensitivity factor, and characteristics of the neutron beam, set by a user if the tumor falls within the maximum treatable depth range; and if not, giving the worst evaluation value, and recording each group of irradiation points, irradiation angles and corresponding evaluation values after finishing the calculation of the evaluation values.
Further, the calculation section outputs data of each set of the irradiation point and the irradiation angle and its corresponding evaluation value in the form of a 3D or 2D image.
Further, the preference section ranks the merits of each set of irradiation points and irradiation angles, and then verifies whether each set of irradiation points and irradiation angles is practicable in order from the merits to the demerits until finding a set of optimum irradiation points and irradiation angles that is practicable.
Further, the preference section finds out all the non-practicable irradiation points and irradiation angles, then rejects the non-implementable irradiation points and irradiation angles, and finally selects an optimal set of the remaining irradiation points and irradiation angles
Drawings
FIG. 1 is a schematic diagram of a boron neutron capture reaction.
FIG. 2 is10B(n,α)7Li neutron capture nuclear reaction equation.
Fig. 3 is a schematic view of a neutron capture therapy device in an embodiment of the invention.
Fig. 4 is a schematic diagram of a control system in an embodiment of the invention.
Fig. 5 is a logic block diagram of calculation of evaluation values of irradiation parameters of a neutron beam in the embodiment of the present invention.
Fig. 6 is a schematic view of an organ track during neutron beam irradiation in an embodiment of the present invention.
Detailed Description
Embodiments of the present invention will be described in further detail below with reference to the accompanying drawings so that those skilled in the art can implement the embodiments with reference to the description.
Neutron capture therapy has been increasingly used in recent years as an effective means of treating cancer, with boron neutron capture therapy being the most common, the neutrons that supply boron neutron capture therapy being supplied by nuclear reactors or accelerators. Boron Neutron Capture Therapy (BNCT) utilizes Boron-containing (B: (B-N-C-B-N-C-10B) The medicine has the characteristic of high capture cross section for thermal neutrons10B(n,α)7Li neutron capture and nuclear fission reaction generation4He and7li two types of heavily charged particles. Referring to FIGS. 1 and 2, schematic and graphical illustrations of boron neutron capture reactions are shown, respectively10B(n,α)7Li neutron capture nuclear reaction equation, the average Energy of two heavy charged particles is about 2.33MeV, and the two heavy charged particles have the characteristics of high Linear Energy Transfer (LET) and short range, the Linear Energy and range of alpha particles are 150 keV/mum and 8μm respectively, and7the Li-heavily charged particles are 175 keV/mum and 5μm, the total range of the two particles is about one cell size, so that the radiation damage to the organism can be limited to the cell level. When the boron-containing medicine selectively gathers in the tumor cells, the purpose of accurately killing the tumor cells can be achieved by matching with a proper neutron source on the premise of not causing too much damage to normal tissues.
Whether the neutron source of boron neutron capture treatment comes from a nuclear reactor or the nuclear reaction of charged particles and a target material, a mixed radiation field is generated, namely a beam comprises neutrons with low energy and high energy and photons; for boron neutron capture therapy of deep tumors, the greater the amount of radiation other than epithermal neutrons, the greater the proportion of non-selective dose deposition in normal tissue, and therefore the radiation that would cause unnecessary dose deposition should be minimized. To better understand the dose distribution of neutrons in the human body, in addition to the air beam quality factor, the embodiment of the present invention uses a human head tissue prosthesis to perform dose distribution calculation, and uses the prosthesis beam quality factor as a design reference of the neutron beam.
The International Atomic Energy Agency (IAEA) gives five air beam quality factor suggestions aiming at a neutron source for clinical boron neutron capture treatment, and the five suggestions can be used for comparing the advantages and disadvantages of different neutron sources and serving as reference bases for selecting neutron generation paths and designing beam integrators. The five proposals are as follows:
epithermal neutron beam flux Epithermal neutron flux>1x 109n/cm2s
Fast neutron contamination<2x 10-13Gy-cm2/n
Photon contamination of Photon contamination<2x 10-13Gy-cm2/n
Thermal to epithermal neutron flux ratio of thermal to epithermal neutron flux ratio <0.05
Neutron current to flux ratio epithermal neutron current to flux ratio >0.7
Note: the super-thermal neutron energy region is between 0.5eV and 40keV, the thermal neutron energy region is less than 0.5eV, and the fast neutron energy region is greater than 40 keV.
1. Epithermal neutron beam flux:
the neutron beam flux and the boron-containing drug concentration in the tumor together determine the clinical treatment time. If the concentration of the boron-containing drug in the tumor is high enough, the requirement on the neutron beam flux can be reduced; conversely, if the boron-containing drug concentration in the tumor is low, high-throughput epithermal neutrons are required to administer a sufficient dose to the tumor. IAEA requirements for epithermal neutron beam flux are greater than 10 epithermal neutrons per second per square centimeter9The neutron beam at this flux can generally control the treatment time within one hour for the current boron-containing drugs, and the short treatment time can effectively utilize the limited residence time of the boron-containing drugs in the tumor besides having advantages on the positioning and comfort of the patient.
2. Fast neutron contamination:
since fast neutrons cause unnecessary normal tissue doses and are therefore considered contamination, the dose magnitude and neutron energy are positively correlated, and the fast neutron content should be minimized in the neutron beam design. Fast neutronContamination is defined as the fast neutron dose accompanied by a unit epithermal neutron flux, and IAEA suggests less than 2x 10 fast neutron contamination-13Gy-cm2/n。
3. Photon contamination (gamma ray contamination):
gamma rays belong to the intense penetrating radiation and can non-selectively cause the deposition of dose on all tissues on the neutron beam path, so that the reduction of the content of the gamma rays is also the necessary requirement of beam design, the gamma ray pollution is defined as the gamma ray dose accompanied by unit epithermal neutron flux, and the recommendation of IAEA for the gamma ray pollution is less than 2x 10-13Gy-cm2/n。
4. Thermal neutron to epithermal neutron flux ratio:
because the thermal neutrons have high attenuation speed and poor penetrating power, most energy is deposited on skin tissues after entering a human body, and the thermal neutrons content is reduced aiming at deep tumors such as brain tumors and the like except that the epidermal tumors such as melanoma and the like need to use thermal neutrons as a neutron source for boron neutron capture treatment. The IAEA to thermal neutron to epithermal neutron flux ratio is recommended to be less than 0.05.
5. Neutron current to flux ratio:
the neutron current to flux ratio represents the directionality of the beam, the larger the ratio is, the better the beam directionality is, the high-directionality neutral beam can reduce the dosage of the surrounding normal tissues caused by neutron divergence, and in addition, the treatable depth and the positioning posture elasticity are also improved. The IAEA to neutron current to flux ratio is recommended to be greater than 0.7.
The prosthesis is used to obtain the dose distribution in the tissue, and the quality factor of the prosthesis beam is deduced according to the dose-depth curve of the normal tissue and the tumor. The following three parameters can be used to make comparisons of therapeutic benefits of different neutron beams.
1. Effective treatment depth:
the tumor dose is equal to the depth of the maximum dose of normal tissue, after which the tumor cells receive a dose less than the maximum dose of normal tissue, i.e. the advantage of boron neutron capture is lost. This parameter represents the penetration of the beam, with greater effective treatment depth indicating a greater depth of tumor that can be treated, in cm.
2. Effective treatment depth dose rate:
i.e. the tumor dose rate at the effective treatment depth, is also equal to the maximum dose rate for normal tissue. Because the total dose received by normal tissues is a factor influencing the size of the total dose which can be given to the tumor, the parameter influences the length of the treatment time, and the larger the effective treatment depth dose rate is, the shorter the irradiation time required for giving a certain dose to the tumor is, and the unit is cGy/mA-min.
3. Effective therapeutic dose ratio:
the average dose ratio received from the surface of the brain to the effective treatment depth, tumor and normal tissues, is called the effective treatment dose ratio; the average dose can be calculated by integrating the dose-depth curve. The larger the effective therapeutic dose ratio, the better the therapeutic benefit of the beam.
In order to make the beam shaper design more dependent, in addition to the five IAEA suggested in the beam quality factor in air and the three parameters mentioned above, the following parameters for evaluating the beam dose performance are also utilized in the embodiments of the present invention:
1. the irradiation time is less than or equal to 30min (proton current used by an accelerator is 10mA)
2. 30.0RBE-Gy for treating depth greater than or equal to 7cm
3. Maximum tumor dose is more than or equal to 60.0RBE-Gy
4. Maximum dose of normal brain tissue is less than or equal to 12.5RBE-Gy
5. Maximum skin dose not greater than 11.0RBE-Gy
Note: RBE (relative Biological effect) is the relative Biological effect, and since the Biological effects caused by photons and neutrons are different, the above dose terms are multiplied by the relative Biological effects of different tissues to obtain the equivalent dose.
As shown in fig. 3, a neutron capture therapy system 100 for implementing neutron capture therapy includes a neutron beam generating module 1, an irradiation room 2 for irradiating a subject, such as a patient, with a neutron beam, a preparation room 3 for performing preparation before irradiation, a communication room 4 for communicating the irradiation room 2 with the preparation room 3, a management room 5 for performing irradiation control, a positioning device (not shown) for positioning the patient, a table 6 that moves in the preparation room 3 and the irradiation room 2 for placing the patient, and a control system 7 for controlling and managing a therapy process.
The neutron beam generating module 1 is configured to generate a neutron beam outside the irradiation chamber 2 and to irradiate the patient placed in the irradiation chamber 2 with the neutron beam, and a collimator 20 is provided in the irradiation chamber 2. The preparation room 3 is a room for performing a preparation work required before the irradiation of the patient with the neutron beam, and the preparation work includes fixing the patient on the table 6, positioning the tumor of the patient, and providing a three-dimensional positioning mark and the like, and the preparation room 3 is provided with the collimator 30. The management room 5 is a room for managing and controlling the entire treatment process performed by the boron neutron capture therapy system 100, and for example, a manager visually checks the state of the preparation work in the preparation room 3 from the room of the management room 5, and the manager operates the control system 7 to control the start and stop of the irradiation of the neutron beam, the position adjustment of the table 6, and the like, and the table 6 is configured to rotate, translate, and move up and down with the patient. The control system 7 is a general term, and may be a single set of control system, in which the start and stop of irradiation of the neutron beam, the position adjustment of the stage 6, and the like are controlled by a single set of system, or may be a plurality of sets of control systems, in which the start and stop of irradiation of the neutron beam, the position adjustment of the stage 6, and the like are controlled by a single set of control system.
Referring to fig. 4, before performing boron neutron capture therapy, the manager needs to determine the angle from which the neutron beam irradiates the patient to kill tumor cells to the maximum extent and reduce the damage of radiation to surrounding normal tissues as much as possible, and after determining the optimal irradiation point and irradiation angle, adjust the table 6 on which the patient is placed to the corresponding position. Specifically, the control system 7 includes an irradiation parameter selection device 71 that selects an optimum irradiation point and an irradiation angle that can be implemented, a conversion unit 72 that converts parameters of the optimum irradiation point and the irradiation angle that can be implemented into coordinate parameters of the stage 6, an adjustment unit 73 that adjusts the stage 6 to a coordinate position obtained from the conversion unit 72, and an on-off unit 74 that controls start and stop of irradiation of the neutron beam.
As shown in fig. 4, each set of irradiation parameters includes irradiation points and irradiation angles of the neutron beam, the irradiation parameter selection device 71 includes a sampling unit 711, a calculation unit 712, and a selection unit 713, wherein the sampling unit 711 selects a plurality of sets of irradiation points and irradiation angles, the calculation unit 712 calculates evaluation values corresponding to the irradiation points and the irradiation angles of each set, and the selection unit 713 selects a set of optimal executable irradiation parameters from all the sampled irradiation points and irradiation angles according to the evaluation values calculated by the calculation unit 712, specifically, the selection unit 713 rejects the irradiation parameters that are not executable in the actual treatment process and selects a set of optimal executable irradiation parameters. The selection of the irradiation points and the irradiation angles by the sampling part 711 can be random or regular, the calculation of the evaluation value calculates the organ track of the patient through which the neutron beam passes, that is, the calculation part 712 calculates the incident depth and the type of the organ through which the neutron beam enters the human body, and then judges whether the tumor falls within the maximum treatable depth range corresponding to the group of irradiation parameters according to the track information of the neutron beam passing through the human body, if so, the evaluation value corresponding to the group of irradiation points and the irradiation angles is calculated according to the data, such as the boron concentration in the organ, the organ radiation sensitivity factor, the neutron beam characteristic information and the like, set by a user by matching the track information; if not, giving a worst evaluation value to the irradiation point and the irradiation angle, and sampling and calculating the irradiation point and the irradiation angle of the neutron beam again. After the evaluation values corresponding to the plurality of groups of irradiation points and irradiation angles are calculated, the advantages and disadvantages of each group of irradiation points and irradiation angles can be visually ranked according to the evaluation values. Since the position of the collimator 20 is fixed and a positioning device or the like is further provided in the irradiation chamber 2, there are cases where some positions of the patient cannot be moved and some movement positions of the couch interfere with each other, and some parts of the patient, such as eyes, cannot be irradiated, so that some irradiation points and irradiation angles cannot be irradiated, and in the actual treatment process, the preferred part 713 is required to eliminate the irradiation points and irradiation angles that cannot be irradiated.
Referring to fig. 5 and 6, a detailed description will be given of a method for using the irradiation parameter selecting device 71, which includes the following steps: the sampling part 711 reads images with clear human anatomy, such as CT/MRI/PET-CT, etc., defines the outlines of organs, tissues and tumors one by one, gives the set material types and densities, selects the irradiation points and irradiation angles of neutron beams after the definitions of the outlines, the materials and the densities are completed, and selects the irradiation points and the irradiation angles, wherein the selection of the irradiation points can be forward selection or reverse selection, the forward selection is to determine the irradiation points at the positions outside the human body and can sample according to fixed angles or distance intervals in sequence, and the sampling can also be performed in a random sampling mode; the neutron beam angle can be set as the vector direction from the irradiation point to the center of mass of the tumor or the deepest part of the tumor; the reverse selection is to determine the irradiation point within the tumor range, wherein the irradiation point can be the center of mass or the deepest part of the tumor, and the neutron beam angle can be performed by random sampling or sampling at predetermined interval angles; after the irradiation point and the irradiation angle of the neutron beam are determined, the calculation part 712 calculates the track of the organ through which the neutron beam passes, i.e. the type and the thickness of the organ through which the neutron beam passes after entering the human body, and after the track information of the neutron beam passing through the human body is obtained, judges whether the tumor falls within the maximum treatable depth range, if so, calculates the evaluation value corresponding to the irradiation point and the irradiation angle according to the track information by combining the information of the organ boron-containing concentration, the organ radiation sensitivity factor, the neutron beam characteristic and the like set by the user; and if not, giving the worst evaluation value, sampling the irradiation point and the irradiation angle of the neutron beam again, and recording the irradiation point, the irradiation angle and the corresponding evaluation value after the evaluation value is calculated. Repeatedly sampling and calculating to a certain number, and outputting a report; the optimizing unit 713 selects an optimal set of implementable irradiation parameters among all the sampled irradiation parameters. The calculation unit 712 may output data of the irradiation point, the irradiation angle, and the evaluation value corresponding thereto in the form of a 3D or 2D image, and in this case, the doctor or the physicist can more intuitively determine the merits of the irradiation point and the irradiation angle.
Preferably, the priority selection unit 713 ranks the merits of each set of irradiation points and irradiation angles, and then verifies whether each set of irradiation points and irradiation angles is practicable in order from the merits to the demerits until finding a set of optimum irradiation points and irradiation angles that is practicable. Of course, the preference part 713 may also find out all the non-implementable irradiation points and irradiation angles after calculating the evaluation value, then eliminate the non-implementable irradiation points and irradiation angles, and finally select an optimal group of the remaining irradiation points and irradiation angles to implement the neutron capture treatment; the preference unit 713 may exclude, in advance, the irradiation points and the irradiation angles that are not applicable before the calculation of the evaluation value, and may select an optimal set of irradiation points and irradiation angles to perform the neutron capture therapy after the calculation is completed.
The preference process may be performed completely automatically by the relevant equipment, or may be performed partially manually, or may be performed completely manually, that is, without setting the preference part 713, for example: the impracticable irradiation points and irradiation angles can be listed by experienced doctors, or can be determined by related equipment simulation, and so on are the ranking of the evaluation values and the action of selecting the optimal irradiation points and irradiation angles after excluding the impracticable irradiation points and irradiation angles. After the optimum irradiation point and irradiation angle that can be implemented are obtained, the conversion unit 72 converts the parameters of the irradiation point and irradiation angle into coordinate parameters that the table 6 needs to be moved into position during irradiation, in conjunction with CT/MRI/PET-CT information, positioning information, configuration information of the table 6, and the like of the patient, and the adjustment unit 73 adjusts the table 6 to a predetermined position based on the coordinate information obtained from the conversion unit 72. After the adjusting unit 73 adjusts the table 6 to the predetermined position, the positioning device further determines whether the irradiation point and the irradiation angle of the neutron beam with respect to the patient tumor are the same as the pre-selected and implementable optimal irradiation point and irradiation angle, and if not, manually adjusts the patient positioning or the table 6 position to ensure that the neutron beam irradiates the patient tumor at the optimal irradiation point and irradiation angle, or drives the adjusting unit 73 to adjust the table 6 position to ensure that the neutron beam irradiates the patient tumor at the optimal irradiation point and irradiation angle.
In order to prevent radiation in the irradiation room 2 from scattering outside the irradiation room 2, a first shield door 21 is provided between the irradiation room 2 and the communication room 4, and a second shield door 31 is provided between the communication room 4 and the preparation room 3. In other embodiments, the first and second screen doors 21, 31 may be replaced with screen walls providing a labyrinth having a shape including, but not limited to, "Z" -shaped, "bow" -shaped, "hex" -shaped.
A specific example of calculating the evaluation value by the calculation unit 712 will be described in detail, but the evaluation value is not limited to this example, and other methods and presentations may be used. The evaluation value is calculated based on neutron beam characteristics, organ radiation sensitivity factor and organ boron concentration, and the weighting factor (W (i)) of the organ i corresponding to a certain irradiation point and irradiation angle is calculated as shown in formula I, wherein I (i), S (i) and C (i) are neutron intensity, organ radiation sensitivity factor and organ boron concentration, respectively.
W (i) x s (i) x c (i) (formula one)
Wherein I (i) is obtained by integrating the depth intensity or dose curve of the neutron beam in the simulated human body, as shown in formula II, wherein i (x) is the function of the depth intensity or dose curve of the neutron beam in the therapeutic treatment in the simulated human body, and x0-x is the depth range of the organ i in the neutron beam trajectory.
After the calculation of the weighting factors of each organ in the organ track is sequentially completed by the algorithm, the weighting factors are summed up to obtain the evaluation value corresponding to the neutron beam, as shown in formula three, in the calculation, the weighting factors of the tumor should not be included in the calculation.
Based on the above evaluation values, the degree of damage to normal tissues during treatment can be determined more intuitively. In addition to the evaluation of the irradiation position and angle using the evaluation value, the evaluation may also be performed using an evaluation ratio factor, which is defined as a ratio of the evaluation value to the tumor weight factor, as shown in equation four, so that the desired therapeutic effect of the irradiation position and angle can be more fully exhibited.
In the above embodiments, the steps of "reading the images with definite human anatomy of the patient, such as CT/MRI/PET-CT, etc., defining the contour of each organ, tissue and tumor one by one, and setting the material type and density. "patent application entitled" geometric model building method based on medical image data "filed by the applicant at 11/17/2015 under the name of 201510790248.7, which is filed by the national intellectual property office, is incorporated herein in its entirety.
As is well known to those skilled in the art, some simple transformations of equations one through four above, such as I (i), S (i), and C (i), transform from multiplicative to additive; i (i), S (i) and C (i) are multiplied by the power of n respectively, and n can be integral multiple of 1 or other multiples according to the situation; i (x) may be x0The mean or median number between x times (x)0-x), or any calculation method that can achieve a result that is consistent with the intensity integration calculation.
Although illustrative embodiments of the invention have been described above to facilitate the understanding of the invention by those skilled in the art, it should be understood that the invention is not limited to the scope of the embodiments, and that various changes will become apparent to those skilled in the art within the spirit and scope of the invention as defined and defined in the appended claims.
Claims (10)
1. A control system for controlling a neutron capture therapy device, the neutron capture therapy device including a table for carrying a patient, the control system comprising:
the irradiation parameter selection device is used for selecting the best practicable irradiation point and irradiation angle;
a conversion unit for converting parameters of an optimum irradiation point and an irradiation angle that can be implemented into coordinate parameters for which the stage needs to be moved in place; and
and an adjusting section for adjusting the mounting table to the coordinate position obtained from the converting section.
2. The control system of claim 1, wherein: the irradiation parameter selection device comprises a sampling part, a calculation part and a preference part, wherein the sampling part selects multiple groups of irradiation points and irradiation angles, the calculation part calculates evaluation values corresponding to each group of irradiation points and irradiation angles, and the preference part selects a group of optimal implementable irradiation points and irradiation angles from all sampled irradiation points and irradiation angles according to the evaluation values calculated by the calculation part.
3. The control system of claim 2, wherein: the conversion unit converts parameters of an optimum irradiation point and an optimum irradiation angle that can be implemented into coordinate parameters for which the table needs to be moved in place during irradiation, in combination with CT/MRI/PET-CT information, positioning information, table configuration information, and the like of the patient.
4. Use of a control system according to any of claims 1-3, characterized in that: the method comprises the following steps:
the irradiation parameter selection device selects the best practical irradiation point and irradiation angle;
the conversion part converts the parameters of the best irradiation point and the irradiation angle which can be implemented into the coordinate parameters of the loading platform which needs to be moved in place;
the adjusting unit adjusts the mounting table to the coordinate position obtained from the converting unit.
5. Use of a control system according to claim 4, characterized in that: the irradiation parameter selection device comprises a sampling part, a calculation part and a preference part, and the use method of the irradiation parameter selection device is as follows: first, the sampling unit selects a plurality of sets of irradiation points and irradiation angles, the calculation unit calculates evaluation values corresponding to the irradiation points and the irradiation angles for each set, and the selection unit selects an optimum set of practicable irradiation points and irradiation angles among all the sampled irradiation points and irradiation angles based on the evaluation values calculated by the calculation unit.
6. Use of a control system for neutron capture therapy according to claim 5, wherein: the neutron capture treatment equipment adopts neutron beams to irradiate a patient to realize treatment, the sampling part reads images with definite human anatomy such as CT/MRI/PET-CT of the patient, the outlines of organs, tissues and tumors are defined one by one, the set material types and densities are given, and after the outlines, the materials and the densities are defined, irradiation points and irradiation angles of a plurality of groups of neutron beams are selected.
7. Use of a control system for neutron capture therapy according to claim 5, wherein: the calculation part calculates the track of the organ of the patient through which the neutron beam passes, namely calculates the type and thickness of the organ through which the neutron beam passes after entering the human body, judges whether the tumor falls in the maximum treatable depth range after acquiring the track information of the neutron beam passing through the human body, and calculates the evaluation value corresponding to the irradiation point and the irradiation angle according to the track information by combining the information of boron-containing concentration of the organ, radiation sensitivity factor of the organ, the characteristics of the neutron beam and the like set by a user if the tumor falls in the maximum treatable depth range; and if not, giving the worst evaluation value, and recording each group of irradiation points, irradiation angles and corresponding evaluation values after finishing the calculation of the evaluation values.
8. Use of a control system for neutron capture therapy according to claim 5, wherein: the calculation unit outputs data of each set of irradiation point and irradiation angle and its corresponding evaluation value in the form of a 3D or 2D image.
9. Use of a control system for neutron capture therapy according to claim 5, wherein: the preferred part ranks the advantages and disadvantages of each set of irradiation points and irradiation angles, and then verifies whether each set of irradiation points and irradiation angles can be implemented in sequence from the advantages to the disadvantages until finding out a set of implementable optimal irradiation points and irradiation angles.
10. Use of a control system for neutron capture therapy according to claim 5, wherein: the preferred part firstly finds out all the non-implementable irradiation points and irradiation angles, then rejects the non-implementable irradiation points and irradiation angles, and finally selects an optimal group from the remaining irradiation points and irradiation angles.
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910908146.9A CN112546456B (en) | 2019-09-25 | 2019-09-25 | Control system for neutron capture therapy and method of use thereof |
| AU2020355832A AU2020355832B2 (en) | 2019-09-25 | 2020-09-24 | Irradiation parameter selection apparatus and usage method thereof and control system comprising said apparatus and usage method thereof |
| CA3150365A CA3150365C (en) | 2019-09-25 | 2020-09-24 | Irradiation parameter selection apparatus and usage method thereof and control system comprising said apparatus and usage method thereof |
| PCT/CN2020/117285 WO2021057828A1 (en) | 2019-09-25 | 2020-09-24 | Irradiation parameter selection apparatus and usage method thereof and control system comprising said apparatus and usage method thereof |
| JP2022518985A JP7437491B2 (en) | 2019-09-25 | 2020-09-24 | Irradiation parameter selection device and method of using the same, control system including the device and method of using the same |
| EP20867547.0A EP4035731A4 (en) | 2019-09-25 | 2020-09-24 | Irradiation parameter selection apparatus and usage method thereof and control system comprising said apparatus and usage method thereof |
| TW109133373A TWI761966B (en) | 2019-09-25 | 2020-09-25 | An irradiation parameter selection device and its using method |
| TW109133375A TWI760862B (en) | 2019-09-25 | 2020-09-25 | A control system for controlling neutron capture therapy equipment and a method of use thereof |
| TW111107862A TWI791390B (en) | 2019-09-25 | 2020-09-25 | Application method of neutron capture therapy equipment and irradiation parameter selection device |
| US17/690,134 US20220193452A1 (en) | 2019-09-25 | 2022-03-09 | Irradiation parameter selection apparatus and usage method thereof and control system comprising the apparatus and usage method thereof |
| AU2024200068A AU2024200068A1 (en) | 2019-09-25 | 2024-01-04 | Irradiation parameter selection apparatus and usage method thereof and control system comprising said apparatus and usage method thereof |
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