CN112546181A

CN112546181A - Medicinal liquor for treating gout and preparation process thereof

Info

Publication number: CN112546181A
Application number: CN202011508957.9A
Authority: CN
Inventors: 王涵
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-12-18
Filing date: 2020-12-18
Publication date: 2021-03-26

Abstract

The invention relates to a medicinal liquor for treating gout and a preparation process thereof, wherein the medicinal liquor comprises the following raw materials in parts by weight: 6-15 parts of Chinese date, 3-10 parts of dried orange peel, 10-15 parts of poria cocos, 9-15 parts of semen cassiae, 5-8 parts of pawpaw, 5-10 parts of chrysanthemum, 9-18 parts of chicory, 3-6 parts of fructus amomi, 3-10 parts of endothelium corneum gigeriae galli, 9-15 parts of caulis spatholobi, 2-4 parts of medlar and 2-4 parts of sika deer sinew. The invention has the beneficial effects that: compared with externally-used plaster, cream, oral tablets and concentrated liquid medicine, the Chinese herbal medicine is prepared into the medicinal liquor, so that the Chinese herbal medicine is more direct and effective, the high uric acid content of the Chinese herbal medicine is directly reduced through the internal administration stage treatment course, the pain part of arthritis, gout and rheumatoid arthritis directly reaches the focus, the Chinese herbal medicine has quick response, does not cause damage to the liver and kidney functions of gastrointestinal tracts, does not have toxic or side effect, pain and wound, and can play a good role in dispelling wind and removing dampness.

Description

Medicinal liquor for treating gout and preparation process thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to medicinal liquor for treating gout and rheumatoid arthritis and a preparation process thereof.

Background

Gout is a disease caused by the increase of uric acid in blood due to long-term purine metabolic disorder or reduction of uric acid excretion, and clinically, hyperuricemia, rheumatoid arthritis and rheumatic pain are included, and chronic arthritis, joint deformity and the like caused by kidney are involved in the later period of part of people. At present, western medicines for treating gout are mainly medicines for promoting uric acid excretion and the like, have large side effects, are slow in efficacy and long in treatment course for ancient Chinese medicines, and increase the trouble and hopelessness of patients.

Disclosure of Invention

The medicinal liquor can be used for preventing and treating gout, has obvious curative effect, can effectively avoid relapse, has no toxic or side effect, breaks through the defect that most of medicinal components of traditional Chinese medicinal materials cannot be released in the conventional technology, and extracts animal raw materials and plant raw materials respectively to enable respective medicinal effects to be fully exerted.

In order to solve the technical problems, the technical scheme provided by the invention is as follows: a medicated liquor for treating gout is prepared from radix Codonopsis, Syngnathus, ligamentum Cervi, asterias amurensis Lutken, concha, rhizoma Ligustici Chuanxiong, pericarpium Citri Tangerinae slice, fructus Chaenomelis, rhizoma Drynariae, cortex Acanthopanacis, flos Chrysanthemi, herba Cichorii, fructus Amomi, semen Cassiae, endothelium corneum Gigeriae Galli, herba Cynomorii, Carthami flos, radix Paeoniae alba, fructus Rosae Laevigatae, rhizoma Gastrodiae, radix Morindae officinalis, fructus Lycii, YIKOUZHONG, fructus Jujubae, Arecae semen, radix Cudraniae, herba Senecionis Cannabifolii, Poria, radix astragali, fructus Gardeniae, caulis Spatholobi, Notoginseng radix, Ningpo Yam rhizome, radix Clematidis, Coptidis rhizoma, flos Magnoliae, fructus Xanthii, rhizoma corydalis, Agkistrodon, cortex Schizophragmatis Integrifolii Radicis, herba Menthae, radix Cynanchi Paniculati, radix Curcumae, radix Angelicae Dahuricae, radix Saposhnikoviae, Bombyx Batryticatus, rhizoma Atractylodis, Olibanum, radix Aconiti, herba asari, radix Angelicae sinensis, radix Gentianae Marcrophyllae, radix Aconiti, And (4) preventing the disease.

The weight portions of the components are as follows: 15-20 parts of codonopsis pilosula, 5-8 parts of syngnathus, 50-80 parts of sika deer sinew, 15-20 parts of starfish, 5-8 parts of concha haliotidis, 30-40 parts of ligusticum wallichii, 50-60 parts of rhizoma drynariae, 50-60 parts of tangerine peel thread, 100 parts of pawpaw, 80-100 parts of cortex acanthopanacis, 20-30 parts of cynomorium songaricum, 60-70 parts of safflower, 40-60 parts of radix paeoniae alba, 45-50 parts of cherokee rose fruit, 15-30 parts of chrysanthemum, 20-30 parts of endothelium corneum gigeriae galli, 20-30 parts of semen cassiae, 30-50 parts of chicory, 10-20 parts of fructus amomi, 100 parts of rhizoma gastrodiae, 20-30 parts of baiji, 50-60 parts of medlar, 20-30 parts of cathaytea, 40-50 parts of red dates, 10-15 parts of betelnut, 100 parts of cudrania cochinchinensis, 30-40 parts of cu, 45-60 parts of astragalus mongholicus, 30-40 parts of gardenia, 80-90 parts of caulis spatholobi, 120 parts of 100-one of panax notoginseng, 250 parts of rhizoma dioscoreae nipponicae, 100-one of radix clematidis, 50-60 parts of coptis chinensis, 30-100 parts of magnolia flower, 90-120 parts of cocklebur fruit, 90-120 parts of rhizoma corydalis, 90-100 parts of long-nosed pit viper, 100-one of schizophragma integrifolia, 110 parts of mint, 10-30 parts of cynanchum paniculatum, 10-30 parts of radix curcumae, 10-20 parts of radix angelicae, 30-50 parts of radix sileris, 30-50 parts of stiff silkworm, 10-30 parts of rhizoma atractylodis, 5-10 parts of frankincense, 5-10 parts of radix aconiti, 5-10 parts of asarum, 20-40 parts of angelica sinensis, 5-10 parts of curcuma longa, 20-50 parts of gentiana macrophylla, 10-30 parts of noto, 50-80 parts of tripterygium wilfordii, 20-30 parts of parasitic loranthus, 3-6 parts of castor bean, 5-10 parts of prepared kusnezoff monkshood root, 20-40 parts of teasel root, 10-20 parts of ephedra, 20-40 parts of medicinal cyathula root, 20-30 parts of eucommia bark, 10-30 parts of cassia twig, 20-40 parts of fineleaf schizonepeta herb, 20-40 parts of rhizoma cibotii, 30-50 parts of baical skullcap root, 20-50 parts of red paeony root, 5-8 parts of rhubarb, 30-50 parts of semen chebulae, 20-40 parts of oriental waterplantain rhizome and 10.

The preparation process of the medicinal liquor for treating gout further comprises the following steps:

(a) taking corresponding raw materials for preparation: cleaning Syngnathus, Cervus Nippon Temminck et Schlegel, starfish, and conch, freezing, storing, taking out, mincing, drying, performing microwave puffing treatment to obtain medicinal powder, adding alkaline solution into the medicinal powder, filtering to obtain primary filtrate, adding protease solution into the primary filtrate, inactivating protease after enzymolysis, filtering to obtain secondary filtrate, adding pure wine into the secondary filtrate, standing, filtering to obtain supernatant, and obtaining first filtrate;

(b) taking corresponding raw materials, and extracting: radix codonopsitis, rhizoma ligustici wallichii, drynaria rhizome, dried orange peel, pawpaw, cortex acanthopanacis, cynomorium songaricum, safflower, radix paeoniae alba, cherokee rose fruit, rhizoma gastrodiae, radix bambusae, medlar, yikoua, red date, betel nut, cudrania cochinchinensis, senecio cannabifolius, poria cocos, radix astragali, gardenia, caulis spatholobi, pseudo-ginseng, dioscorea nipponica, radix clematidis, flos magnoliae, fructus xanthii, rhizoma corydalis, agkistrodon acutus, schizophragma integrifolium, mint, paniculate swallowwort root, radix curcumae, radix angelicae dahuricae, radix sileris, stiff silkworm, rhizoma atractylodis, frankincense, radix aconiti, asarum, angelica sinensis, turmeric, gentiana macrophylla, notopterygium root, radix angelicae pubescentis, radix aconiti, tripterygium wilford. Moistening by spraying, placing into a container, pressurizing, heating, maintaining the temperature, instantly reducing pressure, and drying to obtain medicinal material;

(c) taking corresponding raw materials, and mixing: mixing the primary filtrate and the secondary filtrate, concentrating, standing, and filtering to obtain medicated liquor for treating gout;

(d) taking corresponding raw materials: in the step of waiting for treatment, the pressure of the microwave puffing treatment is 0.5-1.0MPa, and the time is 4-6 min;

(e) taking corresponding raw materials: in the step of treating, the pH of the alkaline solution is 11-12, and the weight volume ratio of the medicinal powder to the alkaline solution is 1 g: (2.2-3.0) mL;

(f) taking corresponding raw materials: in the pretreatment step, the volume ratio of the protease solution to the primary filtrate is 1: (3-4.5); the volume ratio of the pure brewing wine to the secondary filtrate is 1: (5-6);

(g) taking corresponding raw materials, pressurizing to 1.2-3MPa in the extraction step, and heating to 80-90 ℃;

(h) taking corresponding raw materials, keeping the temperature unchanged for 5-10s in the extraction step, and reducing the pressure to normal pressure;

(i) the corresponding raw materials are taken and concentrated to 1/6-1/4 of the original volume in the mixing step.

The invention has the beneficial effects that: the medicinal liquor for treating gout can be used for preventing and treating gout, has an obvious curative effect, can effectively avoid gout recurrence, has no side effect, is a green therapy, and has the effects of dispelling wind, removing dampness, clearing and activating channels and collaterals; the preparation process of the medicinal liquor for treating gout breaks through the defects of active ingredients and most of the medicinal ingredients in traditional Chinese medicinal materials in the conventional technology that the medicinal ingredients cannot be released, and the animal raw materials and the plant raw materials are respectively extracted, so that the respective medicinal effects can be fully exerted, and the medicinal liquor has good curative effects on gout and uric acid reduction.

Drawings

FIG. 1 is a total ion flow chart of Chinese medicinal extract in positive ion mode and blank control.

FIG. 2 is a total ion flow graph of Chinese herbal extract in negative ion mode and blank control.

FIG. 3 is a sample FTIR spectrum.

Fig. 4 is a sample FTIR match spectrum.

FIG. 5 is a sample NMR spectrum (CDCl 3).

FIG. 6 is a sample NMR spectrum (D2O).

FIG. 7 is a GC-MS spectrum of a sample.

Figure 8 is an XRF spectrum of the sample.

FIG. 9 is a MS (+) spectrum of a sample.

FIG. 10 is a MS (-) spectrum of the sample.

Detailed Description

The invention is illustrated below by means of specific examples, without being restricted thereto.

Example one

(a) Taking corresponding raw materials: cleaning Syngnathus, Cervus Nippon Temminck et Schlegel, starfish and conch, freezing and storing, taking out, mincing, drying, performing microwave puffing treatment to obtain medicinal powder, adding the medicinal powder into alkaline solution, filtering to obtain primary filtrate, adding protease solution into the primary filtrate, inactivating protease after enzymolysis, filtering to obtain secondary filtrate, adding pure wine into the secondary filtrate, standing, filtering to obtain supernatant, and obtaining first filtrate;

(b) taking corresponding raw materials, and extracting: radix Codonopsis, rhizoma Ligustici Chuanxiong, rhizoma Drynariae, pericarpium Citri Tangerinae, fructus Chaenomelis, cortex Acanthopanacis, herba Cynomorii, Carthami flos, radix Paeoniae alba, fructus Rosae Laevigatae, fructus Lycii, YIKOUZHONG, rhizoma Gastrodiae, fructus Jujubae, radix Cudraniae, herba Senecionis Cannabifolii, Poria, Arecae semen, radix astragali, fructus Gardeniae, caulis Spatholobi, radix Morindae officinalis, Notoginseng radix, Ningpo Yam rhizome, radix Clematidis and Coptidis rhizoma, flos Magnoliae, fructus Xanthii, rhizoma corydalis, Agkistrodon, cortex Schizophragmatis Integrifolii Radicis, herba Menthae, radix Cynanchi Paniculati, radix Curcumae, radix Angelicae Dahuricae, radix Saposhnikoviae, Bombyx Batryticatus, rhizoma Atractylodis, Olibanum, herba asari, radix Angelicae sinensis, Curcuma rhizome, radix Gentianae Marcrophyllae, Notopterygii rhizoma, radix Angelicae Pubescentis, radix Aconiti, radix Tripterygii Wilfordii, herba Taxilli. Wetting by spraying, placing into a container, pressurizing, heating, maintaining the temperature constant, then instantly reducing the pressure, and drying to obtain the raw material;

(c) taking corresponding raw materials: putting the raw material for extraction into a container, filtering to remove residues to obtain a second filtrate, and mixing the steps: mixing the primary filtrate and the secondary filtrate, concentrating, standing, and filtering to obtain medicated liquor for treating gout;

(d) the pressure of the microwave puffing treatment is 0.5-1.0MPa, and the time is 4-6 min;

(e) in the step of treating, the pH of the alkaline solution is 11-12, and the weight volume ratio of the medicinal powder to the alkaline solution is 1 g: (2.2-3.0) mL;

(f) in the step of treatment, the weight-to-volume ratio of the protease solution to the primary filtrate is 1: (3-4.5) the weight-volume ratio of the pure brewing wine to the secondary filtrate is 1: (5-6);

(i) mixing the corresponding raw materials, and concentrating to 1/6-1/4.

The animal raw materials are subjected to ultralow temperature extraction treatment, and according to the physical properties and functional component characteristics of animal medicinal materials, the treatment process is refined on the basis of the prior art, so that the efficiency is improved, the damage amplitude of effective components in the extraction process is obviously reduced, and the active components are effectively protected.

The plant raw materials are extracted, the principle is that the cell walls are broken due to the fact that the cell walls cannot bear huge pressure changes through the pressure changes, the technology is used for extracting the plant cells, the physical shape of medicinal materials is not changed, the effect of long-time decoction in the traditional process is avoided, and energy consumption and time are saved.

Effect evaluation and Performance detection

Animal experiments

Hyperuricemia is the basis of gout, and the main sources of uric acid in the body are two aspects, one part is decomposed and metabolized by purine in food through enzyme, and the other part is decomposed and metabolized by nucleic acid and other purine compounds of cells in the body.

Experimental method for determining uric acid in macaque with hyperuricemia

(a)45 macaques with weight of 8-12kg and half of male and female are randomly divided into an experimental group, a control group and a model group, the medicated wine of the process technology of the macaques with the experimental group, the medicated wine of the prior art is respectively drenched into the experimental group, the medicated wine is drenched into the group, the control group is drenched with normal saline once a day and administrated for 10 days, after the last administration is carried out for 30min, the abdominal cavities of the animals of the experimental group, the control group and the model group are injected with hypoxanthine 1mg/kg to cause the blood pressure and the hyperuricemia, the model group is injected with xanthine 1mg/kg in one hour. After 30min of injection, blood is collected from the eyeballs of each group of animals, the collected blood is centrifuged for 15min at 2500r/min, and the blood uric acid value on the serum side is taken.

Hyperuricemia macaque uric acid determination experimental method

(b)45 macaques with the weight of 8-12kg and half male and female are randomly divided into an experimental group, a control group and a model group, the medicated wine of the macaques of the experimental group to the five groups is respectively drenched, the medicated wine of the prior art of the macaques of the group to the two groups is compared, the control group is drenched with normal saline once a day and administrated for 10 days, after the last administration is carried out for 30min, the animals are subjected to intraperitoneal injection of hypoxanthine of the group to the experimental group to the five groups, the group to the two groups and the model group. And (3) injecting primary xanthine, simultaneously irrigating 1mL of physiological saline into the macaque, collecting urine of each group of animals after 1h, and determining the uric acid value.

Experimental results statistical results were used

Table 1 hyperuricemia macaque blood uric acid influence results.

Group of	Number only	Dosage (g/kg)	Blood uric acid level (μmol/L)
				Model set	10	0	6120±1109
Experiment group	10	20	5921±1112
				Two groups of experiments	10	20	6190±1006
Three groups of experiments	10	20	7295±1080
				Experiment four groups	10	20	6201±1028
Five groups of experiments	10	20	6532±1033
				Compare a group	10	20	8015±1205
Comparison of two groups	10	20	8208±1015
				Control group	10	20	150±60

The table shows that the medicinal liquor provided by the embodiment of the invention can obviously reduce the blood uric acid level, the effect on blood uric acid is not obviously different from that of a model group, and the medicinal liquor provided by the invention has the effects of promoting blood circulation, regulating normal purine metabolism, inhibiting the generation of uric acid, promoting the excretion of uric acid and dissolving gout explanation, but the effects of a comparison group are different from those of an experimental group, which shows that the preparation process provided by the invention can obviously improve the effect of the medicinal liquor on animal raw materials and plant raw materials by extraction treatment.

Clinical trial

Case one: xue, 43 years old, the stem of the army, swollen joints and pain of the right foot recur for 2 years, and the blood uric acid is examined in the hospital, and the swollen and deformed joints of the right foot have a great amount of pain. After the medicinal liquor is taken for 10 days, the trouble of pain in ten thousand minutes is solved, and the uric acid is obviously reduced.

Case two: wangzhi, 58 years old, rural house entrance, swelling and pain on both sides of joint. The medicinal liquor is taken 20mL once a day, the pain of the patient is reduced after half a month, and the uric acid is detected to be reduced to a normal index.

Case three: deng Shi, 56 years old, swollen and deformed finger joints of individual households. Pain is troubled repeatedly for many years, finger joints are not painful after the medicinal liquor is taken for about 28 days, and the reduction range of uric acid index is very obvious.

Case four: wangzhi, age 42, teacher, unilateral swelling and pain of the first toe joint. After the medicinal liquor is taken, the medicine can be cured after 5 days, and the uric acid is reduced to the normal standard.

In conclusion, animal experiments and clinical test results show that the medicinal liquor can be used for preventing and treating gout, is remarkable in curative effect, can effectively avoid recurrence, and is small in toxic and side effects.

The research report of the chemical components of the medicinal liquor

First, experiment purpose

The chemical components of the traditional Chinese medicine are researched by using ultra-high performance liquid phase-flight time high resolution mass spectrometry.

Second, preparation method of test sample

Taking 0.2g of sample, putting the sample into a 10ml glass test tube, adding 5ml of 50% methanol-water solution, soaking for 4h, performing ultrasonic treatment at 40 ℃ for 40min, putting the supernatant into a 1ml centrifuge tube, putting the centrifuge tube into a high-speed centrifuge for 1300r/min, centrifuging for 10min, filtering with a 0.22um microporous filter membrane, and putting the filtrate into a 1.5ml autosampler bottle to obtain a traditional Chinese medicine extract sample. Blank samples were obtained under the same conditions. The samples were stored in a refrigerator at 4 ℃ and removed before analysis (storage time not exceeding 24 h).

Third, chromatographic conditions

The chromatographic instrument is as follows: shimadzu LC-30A. Column size C18(1.7 μm, 2.1 × 100 mm); the column temperature was 35 ℃; the flow rate is 0.3 ml/min; the sample amount is 2 mul; the mobile phase was eluted using a gradient of acetonitrile-0.1% aqueous formic acid as detailed in table 1.

Table 1 mobile phase gradient elution procedure

IV, mass spectrum conditions

The mass spectrometer was AB Sciex Triple TOF 5600 +. The ionization mode is an electrospray positive ion mode, the voltage of an ion source is 5500V respectively, the temperature of the ion source is 500 ℃, the cluster removing voltage (DP) is 100V respectively, the Collision Energy (CE) is 35eV respectively, and the Collision Energy Spread (CES) is 15eV respectively. The atomizing gas is nitrogen, the auxiliary gas 1 is 50PSI, the auxiliary gas 2 is 50PSI, and the air curtain gas is 40 PSI. The scanning range of primary mass spectrum parent ions is 50-1000, secondary mass spectrum scanning is carried out on 6 highest peaks with IDA setting response values exceeding 100cps, the scanning range of secondary ions is 50-1000, and Dynamic Background Subtraction (DBS) is started. The ionization mode is an electrospray negative ion mode, the voltage of an ion source is 4500V respectively, the temperature of the ion source is 500 ℃, the cluster removing voltage (DP) is 100V respectively, the Collision Energy (CE) is 35eV respectively, and the Collision Energy Spread (CES) is 15eV respectively. The atomizing gas is nitrogen, the auxiliary gas 1 is 50PSI, the auxiliary gas 2 is 50PSI, and the air curtain gas is 40 PSI. The scanning range of primary mass spectrum parent ions is 50-1000, secondary mass spectrum scanning is carried out on 6 highest peaks with IDA setting response values exceeding 100cps, the scanning range of secondary ions is 50-1000, and Dynamic Background Subtraction (DBS) is started.

Fifth, experimental results

See figures 1 and 2.

Sixthly, analysis of experimental data

Through research and study of documents in the last five years, the experiment searches for common traditional Chinese medicines for treating rheumatic ostealgia, adopts flight time high resolution mass spectrometry to qualitatively detect traditional Chinese medicine extracts, and obtains the following results:

6.1 analysis of active ingredients in Chinese herbs

(1) Detection of Chinese medicine components

The method comprises the following steps of detecting 405 traditional Chinese medicine active ingredients in a positive ion mode and a negative ion mode of the traditional Chinese medicine extract, wherein the mass spectrum response intensity of the active ingredients larger than 50000 is 58, and the active ingredients are respectively sorted according to the mass spectrum response intensity: chrysophanol, daidzein, chrysin, isomaltose, kaempferol-3-O-beta-rutinoside, 6-hydroxy apigenin-3, 6-di-O-beta-D-glucoside, camphenanol-3-O-rutinoside, genistin, puerarin, apigenin-7-glucoside, emodin-6-glucoside, aloe-emodin-8-glucoside, emodin-8-D-glucoside B, emodin, genistein, 6-hydroxy apigenin, baicalein, norwogonin, aloe-emodin, tetrahydrofangchin, violaxanthine, eriodictyol, 5, 7, 2', 6' -tetrahydroxyflavanonol, Levo eriodictyol, proline, formononetin, quercetin, carexin, visfatin I, kaempferol, luteolin, kaempferol, valine, betaine, hesperidin, caryophyllin, allodelivery-4 beta-ol, curcumin, spruce tannic acid, naringenin, cassia toralactone, scopolamine, 1-O-caffeoylquinic acid, chlorogenic acid, scopoletin, palmitic acid, gumbogic alcohol, (+) -cedarone, hederagenin, 2 alpha-hydroxy oleanolic acid, crataegolic acid, quercus roburic acid, wogonin, genkwanin, emodin methyl ether, and limonin.

(2) Analysis of Chinese medicine composition

Classifying the Chinese medicinal active ingredients detected in the Chinese medicaments, and counting the proportion of the detected Chinese medicinal active ingredients in the database so as to judge the prescription of the tonic Chinese medicament.

The proportion of the total detection components in the database is analyzed through chart data, and the following are found:

1. the ratio of the active ingredients detected by 8 Chinese medicaments of cocklebur fruit, clematis root, stiff silkworm, safflower, fineleaf schizonepeta herb, east Asian tree fern rhizome, baical skullcap root and red paeony root in the database is more than 70 percent. Therefore, the possibility of containing the 8 traditional Chinese medicine components in the traditional Chinese medicine formula is high.

2. The ratio of the detected active ingredients of 22 traditional Chinese medicines, namely magnolia flower, corydalis tuber, long-nosed pit viper, schizophragma integrifolium, mint, radix curcumae, angelica dahurica, ligusticum wallichii, rhizoma atractylodis, pseudo-ginseng, asarum, angelica, turmeric, tripterygium wilfordii, loranthus parasiticus, cortex acanthopanacis, ephedra, medicinal cyathula root, eucommia bark, cassia twig, rhubarb and plantain seed, in a database is more than 50 percent, so that the traditional Chinese medicine formula is inferred to possibly contain the 22 traditional Chinese medicine ingredients.

3. The ratio of active ingredients detected in other Chinese medicinal materials in the database is low, and the possibility of containing the Chinese medicinal materials is low.

Detailed information table of Chinese medicine detection components:

and (3) analysis results:

screening results of western medicine components:

the above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims

1. The medicinal liquor for treating gout is characterized by comprising the following raw materials: radix codonopsitis, syngnathus, sika deer sinew, starfish, concha, rhizoma ligustici wallichii, fructus amomi, cassia seed, poria cocos, chicory, chrysanthemum, cassia seed, rhizoma drynariae, dried orange peel, pawpaw, cortex acanthopanacis, cynomorium songaricum, safflower, radix paeoniae alba, cherokee rose, rhizoma gastrodiae, radix morindae officinalis, medlar, yikouchi, red date, betel nut, cudrania root, hempleaf groundsel herb, poria cocos, radix astragali, gardenia, caulis spatholobi, endothelium corneum gigeriae galli, panax notoginseng, dioscorea nipponica, radix clem.

2. The medicinal liquor for treating gout according to claim 1, which is characterized by comprising the following components in parts by weight: 15-20 parts of codonopsis pilosula, 5-8 parts of syngnathus, 50-80 parts of sika deer sinew, 15-20 parts of starfish, 5-8 parts of concha haliotidis, 15-30 parts of chrysanthemum, 30-50 parts of semen cassiae, 30-50 parts of chicory, 10-20 parts of fructus amomi, 30-40 parts of ligusticum wallichii, 50-60 parts of rhizoma drynariae, 50-60 parts of pericarpium citri reticulatae, 100 parts of small pawpaw, 80-100 parts of cortex acanthopanacis, 10-30 parts of endothelium corneum gigeriae galli, 20-30 parts of cynomorium songaricum, 60-70 parts of safflower carthamus, 40-60 parts of radix paeoniae alba, 45-50 parts of cherokee rose fruit, 100 parts of rhizoma gastrodiae, 20-30 parts of baiji, 50-60 parts of medlar, 20-30 parts of fructus eucommiae, 40-50 parts of red dates, 10-15 parts of betelnut, 100 parts of cudrania cochinchinensis, 45-60 parts of astragalus membranaceus, 30-40 parts of cape jasmine, 80-90 parts of caulis spatholobi, 100 parts of pseudo-ginseng, 250 parts of rhizoma dioscoreae nipponicae, 100 parts of radix clematidis and 50-60 parts of coptis chinensis.

3. The preparation process of the medicinal liquor for treating gout according to claim 2 is characterized by comprising the following steps: (a) cleaning Syngnathus, Cervus Nippon Temminck et Schlegel, starfish and conch, freezing, storing, taking out, mincing, drying, performing microwave puffing treatment to obtain medicinal powder, adding alkaline solution into the medicinal powder, filtering to obtain primary filtrate, adding protease solution into the primary filtrate, inactivating protease after enzymolysis, filtering to obtain secondary filtrate, adding pure brewing wine into the secondary filtrate, standing, precipitating, filtering, and taking supernatant to obtain first filtrate;

(b) taking corresponding raw materials, extracting, namely spraying codonopsis pilosula, ligusticum wallichii, rhizoma drynariae, dried orange peel, small pawpaw, cortex acanthopanacis, cynomorium songaricum, safflower, radix paeoniae alba, cherokee rose stone, hempleaf groundsel herb, poria cocos, astragalus mongholicus, gardenia, caulis spatholobi, panax notoginseng, dioscorea nipponica makino, radix clematidis and coptis chinensis, putting into a dissolving device, pressurizing, heating, keeping the temperature constant, then instantly reducing the pressure, and drying to obtain an extracted medicinal material;

(c) taking corresponding raw materials, putting the extracted medicinal materials into a container, and filtering to remove residues to obtain a second filtrate;

(d) mixing the corresponding raw materials, mixing the primary filtrate and the secondary filtrate, concentrating, standing, and filtering to obtain the medicinal liquor for treating gout.

4. The preparation process of the medicinal liquor for treating gout according to claim 3, which is characterized by comprising the following steps: the pressure of the microwave puffing treatment in the step (a) is 0.5-1.0MPa, and the time is 4-6 min.

5. The preparation process of the medicinal liquor for treating gout according to claim 3, which is characterized by comprising the following steps: in the step (a), the PH of the alkaline solution is 11-12, and the weight volume ratio of the medicinal powder to the alkaline solution is 1 g: (2.2-3.0) mL.

6. The preparation process of the medicinal liquor for treating gout according to claim 3, which is characterized by comprising the following steps: the volume ratio of the protease solution to the primary filtrate in the step (a) is 1: (3-4.5), the volume of the pure brewing wine and the secondary filtrate is 1: (5-6).

7. The preparation process of the medicinal liquor for treating gout according to claim 3, which is characterized by comprising the following steps: pressurizing to 1.2-3MPa in the step (b), and heating to 80-90 ℃.

8. The preparation process of the medicinal liquor for treating gout according to claim 3, which is characterized by comprising the following steps: maintaining the temperature unchanged in the step (b) for 5-10s, and reducing the pressure to normal pressure.

9. The preparation process of the medicinal liquor for treating gout according to claim 3, which is characterized by comprising the following steps: the step (c) is a step of extracting animal raw materials and plant raw materials by scientific and technological technology.

10. The preparation process of the medicinal liquor for treating gout according to claim 3, which is characterized by comprising the following steps: and (d) in the mixing and concentrating treatment step, concentrating to 1/6-1/4 of the original volume.