CN112521442A - Active peptide extraction device - Google Patents
Active peptide extraction device Download PDFInfo
- Publication number
- CN112521442A CN112521442A CN202011542917.6A CN202011542917A CN112521442A CN 112521442 A CN112521442 A CN 112521442A CN 202011542917 A CN202011542917 A CN 202011542917A CN 112521442 A CN112521442 A CN 112521442A
- Authority
- CN
- China
- Prior art keywords
- extraction device
- liquid
- reactor
- valve
- flow rate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/145—Extraction; Separation; Purification by extraction or solubilisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Extraction Or Liquid Replacement (AREA)
- Peptides Or Proteins (AREA)
Abstract
The present invention provides an active peptide extraction device, including: the reactor is arranged in the box body, and the electromagnetic wave generator and the spraying branch pipes are alternately arranged in the reactor; the bottom of the reactor is provided with a buffer cavity, and one end of each spraying branch pipe extends into the buffer cavity; the cooling tank is arranged at the lower side of the reactor, and a liquid outlet of the cooling tank is connected with a liquid inlet of the cache cavity through a liquid pump; the liquid inlet of the cooling box is connected with the liquid outlet of the reactor through a pipeline; a first liquid discharge pipe is arranged at the bottom of the cooling box; the extraction device is arranged at the lower side of the box body; one end of the extraction device is in spherical hinge joint with the first liquid discharge pipe, and the other end of the extraction device is provided with a transmission mechanism for driving the bottom end of the extraction device to rotate. The protein solution is sprayed on the surface of the electromagnetic wave generator after being cooled by the cooling box, and is circulated and refluxed for multiple times, so that the electromagnetic wave generator is cooled, simultaneously, the cracking of the protein is promoted, the molecular weight of the active peptide after cracking is reduced, and the bioavailability of the human body is improved.
Description
Technical Field
The invention relates to the technical field of biological extraction equipment, in particular to an active peptide extraction device.
Background
The active peptide is active polypeptide formed by connecting a plurality of amino acids by peptide bonds, and has the functions of regulating the physiological function of the organism and providing nutrition for the organism. The production and preparation of active peptide mainly comprises the following three routes:
firstly, natural active substances inherent to organisms are extracted from organisms in the nature; secondly, obtaining the bioactive peptide with corresponding physiological function through a protein degradation way; thirdly, the bioactive peptide is prepared by an artificial synthesis method. The existing extraction method has relatively high cost, more toxic substances are always remained in the artificial synthesis process, and the extracted peptide chain has relatively low activity and relatively large molecular weight, is not easy to be absorbed by tissues, so that the bioavailability is low.
The extraction process mainly comprises extraction, concentration and purification, and the currently adopted extraction device is easy to generate heat and has overhigh heat in the working process of electromagnetic waves, so that the cracking of protein is easily influenced, and the content of effective cost and the size of molecular weight are finally influenced.
Disclosure of Invention
In order to solve the above problems, the present invention provides an active peptide extraction apparatus, which comprises spraying an extraction liquid on the surface of an electromagnetic wave generator, and decomposing a protein raw material in a reaction solution by electromagnetic waves generated by the electromagnetic wave generator to form polypeptides; the protein solution is sprayed on the surface of the electromagnetic wave generator through the spray heads on the spray branch pipes after passing through a cooling system of the cooling box, and is circulated and refluxed for many times, so that the cracking of the protein is promoted while the electromagnetic wave generator is cooled, the molecular weight of the active peptide after cracking is reduced, the complete absorption of the active peptide by a human body is ensured, and the bioavailability of the human body is improved.
In order to achieve the above object, the technical solution of the present invention is as follows.
An active peptide extraction device comprising:
the reactor comprises a box body, a plurality of spray branch pipes and a plurality of electromagnetic wave generators, wherein the box body is internally provided with a reactor, and the reactor is internally and alternately provided with the electromagnetic wave generators and the spray branch pipes; the bottom of the reactor is provided with a cache cavity, and one end of each spray branch pipe extends into the cache cavity;
the cooling tank is arranged at the lower side of the reactor, and a liquid outlet of the cooling tank is connected with a liquid inlet of the cache cavity through a liquid pump; the liquid inlet of the cooling box is connected with the liquid outlet of the reactor through a pipeline; a first liquid discharge pipe is arranged at the bottom of the cooling box;
the extraction device is arranged on the lower side of the box body; one end of the extraction device is spherically hinged with the first liquid discharge pipe, and the other end of the extraction device is provided with a transmission mechanism for driving the bottom end of the extraction device to rotate.
Further, a spherical fixing piece is arranged at the bottom of the first liquid discharge pipe, and a liquid discharge channel is arranged in the spherical fixing piece; the top of extraction device is provided with spherical hinge, spherical mounting set up in the spherical hinge, and with spherical hinge rotatable coupling.
Furthermore, the spherical hinge joint comprises a spherical rotating seat and a cover body, and the spherical rotating seat is communicated with the extraction device; the cover body is sleeved on the first liquid discharge pipe and is in threaded connection with the spherical rotating seat; the cover body and the spherical rotating seat are combined to form a rotating cavity, and the spherical fixing piece is arranged in the rotating cavity.
Further, a fixing bracket is arranged on the lower side of the box body, a fixing plate is arranged on the fixing bracket, and a fixing hole is formed in the fixing plate;
the transmission mechanism is arranged on the fixing plate; the transmission mechanism includes:
the rotating plate is rotatably arranged on the fixing hole; a turbine turntable is sleeved outside the rotating plate;
the worm is arranged on one side of the turbine turntable and is meshed with the turbine turntable in a tooth form;
the driving motor is arranged at one end of the worm and is used for driving the worm to rotate;
the movable sleeve is eccentrically arranged on the rotating plate; the movable sleeve is rotatably connected with the rotating plate through a universal joint;
and a second liquid discharge pipe is arranged at the bottom of the extraction device, penetrates through the movable sleeve, and the upper end of the movable sleeve is abutted against the extraction device.
Furthermore, a plurality of L-shaped supporting rods are arranged on the fixed support and surround the extraction device, the vertical end of each L-shaped supporting rod is fixedly connected with the fixed support, and the horizontal end of each L-shaped supporting rod extends towards the extraction device;
a sliding block is slidably arranged at the horizontal end of each L-shaped supporting plate, a fixing ring is sleeved on the extraction device, and the fixing ring is clamped with the extraction device; the periphery of the fixing ring is hinged with connecting rods, and one end of each connecting rod is hinged with the corresponding sliding block.
Further, be provided with the filter on the liquid outlet of reactor, rotationally be provided with the doctor-bar subassembly on the filter, the doctor-bar subassembly includes:
the rotating ring is rotatably arranged on the liquid outlet of the reactor, and a plurality of liquid inlet cavity pipes are spirally distributed in the rotating ring;
and the scraping blade is vertically arranged at one end of the rotating ring, and one end of the scraping blade is abutted against the filter plate.
Further, a first valve and a first flow rate detector are arranged on a liquid outlet of the reactor;
a second valve and a second flow rate detector are arranged on a liquid outlet of the cooling box; a liquid level detector is longitudinally arranged on the inner wall of the cooling box; a third valve is arranged on the first liquid discharge pipe;
the top of the reactor is provided with a feeding hole; and a fourth valve is arranged on the feeding hole.
Further, still include:
the microprocessor is arranged outside the box body and used for receiving the liquid level value detected by the liquid level detector and comparing the liquid level value with a first liquid level value and a second liquid level value of a set liquid level range, wherein the first liquid level value is smaller than the second liquid level value;
the microprocessor is also used for receiving a first flow rate value detected by the first flow rate detector and a second flow rate value detected by the second flow rate detector and comparing the first flow rate value with the second flow rate value;
with the opening of the first valve, when the liquid level value detected by the microprocessor is equal to or greater than the first liquid level value, the second valve and the liquid pump are opened to form circulation between the cooling tank and the reactor, and the first flow rate value is greater than the second flow rate value;
and when the level value detected by the microprocessor is equal to or greater than the second level value, closing the first valve, the second valve and the liquid pump, and simultaneously starting the third valve and the fourth valve.
Further, still include:
the power supply module is arranged outside the box body; the electromagnetic wave generator and the liquid pump are electrically connected with the power module.
The invention has the beneficial effects that:
1. the device of the invention sprays the extract liquor on the surface of an electromagnetic wave generator to promote the electromagnetic wave emitted by the electromagnetic wave generator to crack protein raw materials in a reaction solution to form polypeptide; the protein solution is sprayed on the surface of the electromagnetic wave generator through the spray heads on the spray branch pipes after passing through a cooling system of the cooling box, and is circulated and refluxed for many times, so that the cracking of the protein is promoted while the electromagnetic wave generator is cooled, the molecular weight of the active peptide after cracking is reduced, the complete absorption of the active peptide by a human body is ensured, and the bioavailability of the human body is improved.
2. The device is characterized in that the bottom of the box body is connected with the extraction device, the extraction device is small in size, large in size and small in size, the top of the extraction device is hinged with the first liquid discharge pipe, the bottom of the extraction device can be driven to shake through the transmission mechanism, mixing and layering of extraction liquid are facilitated, the structure is simple, and the use is convenient.
Drawings
Fig. 1 is a schematic structural diagram of an embodiment of the present invention.
FIG. 2 is a schematic view of the reactor and cooling tank of FIG. 1.
Fig. 3 is a schematic view of the wiper blade assembly of fig. 1.
Fig. 4 is a schematic cross-sectional view of the filter plate and doctor blade assembly of fig. 1.
Fig. 5 is a schematic structural view of a portion a in fig. 1.
Fig. 6 is a schematic structural diagram of the transmission mechanism in fig. 5.
Fig. 7 is a schematic view of an assembly structure of the extraction device and the first drain pipe in fig. 1.
FIG. 8 is a block diagram of the electrical connections of the control system of the microprocessor according to the embodiment of the present invention.
In the figure: 1. a box body; 2. a reactor; 21. an electromagnetic wave generator; 22. spraying branch pipes; 23. a cache cavity; 24. a filter plate; 25. a wiper blade assembly; 251. a rotating ring; 252. a liquid inlet cavity pipe; 253. scraping a blade; 26. a first valve; 27. a first flow rate detector; 28. a feed inlet; 281. a fourth valve; 3. a cooling tank; 31. a first drain pipe; 311. a spherical fixing member; 312. a third valve; 32. a second valve; 33. a second flow rate detector; 34. a liquid level detector; 4. a liquid pump; 5. an extraction device; 51. a spherical hinge; 511. a spherical rotating seat; 512. a cover body; 52. a second drain pipe; 53. a fixing ring; 54. a connecting rod; 6. a transmission mechanism; 61. a rotating plate; 62. a turbine rotor disk; 63. a worm; 64. a drive motor; 65. a movable sleeve; 7. fixing a bracket; 71. a fixing plate; 711. a fixing hole; 72. an L-shaped support bar; 73. a slider; 8. a microprocessor.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Fig. 1 is a schematic structural diagram of an active peptide extraction apparatus according to an embodiment of the present invention. The active peptide extraction device comprises: the reactor comprises a box body 1, a fixed support 7, a reactor 2 and a cooling box 3 which are arranged in the box body 1, and an extraction device 5 which is arranged on the fixed support 7.
Referring to fig. 1 to 2, a reactor 2 is arranged in a box 1, and an electromagnetic wave generator 21 and a spray branch pipe 22 are alternately arranged in the reactor 2; the bottom of the reactor 2 is provided with a buffer chamber 23, and one end of each spray branch pipe 22 extends into the buffer chamber 23. The central part of the spray branch pipe 22 is provided with a hollow spray pipe, and the outer wall of one end of the spray branch pipe positioned in the reactor is provided with a plurality of spray heads extending towards the corresponding electromagnetic wave generators.
In this embodiment, the electromagnetic wave generator 21 can emit high-frequency or relatively high-frequency electromagnetic waves to the protein raw material solution in the reactor, so that a part of the structure of the protein is destroyed and degraded to form polypeptide, and there may be polypeptide recombination, but this does not affect the activity and nutritional value of the polypeptide formed by degradation or recombination. The working principle is as follows: the resonance energy of specific frequency generated by electromagnetic wave can generate resonance to specific amino acid and conformation thereof, resonate along a specific sequence, and can specifically break protein by transferring and accumulating energy, so that the protein chain is broken to form active polypeptide.
When the reaction solution generating device is used, the reaction solution in the buffer cavity 23 enters the spraying pipeline in the spraying branch pipe due to the influence of external water pressure, and is sprayed on the surface of the electromagnetic wave generator by a plurality of spray heads on the spraying branch pipe. Of course, the surface of the electromagnetic wave generator has a waterproof structure, and the pipeline of the electromagnetic wave generator extends to the outside of the box body through the corresponding hollow pipeline and is connected with the power supply module. Further, a shield layer for shielding electromagnetic waves is provided on the inner wall of the case 1.
The cooling box 3 is arranged at the lower side of the reactor 2 and is positioned in the box body; the liquid outlet of the cooling box 3 is connected with the liquid inlet of the cache cavity 23 through the liquid pump 4; a liquid inlet of the cooling box 3 is connected with a liquid outlet of the reactor 2 through a pipeline; the bottom of the cooling tank 3 is provided with a first drain pipe 31. Here, the electromagnetic wave generator 21 may generate heat while degrading the protein in the reaction solution, and the heat may affect the protein solution if not brought out in time, so that the protein may be precipitated and may be hardly re-dissolved. Specifically, the cooling tank 3 has therein a cooling pipe capable of exchanging heat with the reaction solution in the cooling tank to take out heat in the reaction solution, and has a refrigerating effect such that the reaction solution is rapidly cooled after passing through the cooling tank, and flows back to the buffer chamber 23 through the liquid-pumping pump. The cooling pipeline is connected with a cooler outside the box body to form refrigeration.
In this embodiment, the resonance energy generated by the electromagnetic wave may generate heat during the process of breaking protein chains, and the excessive heat may precipitate the protein, which is not favorable for the dissolution of polypeptide and the subsequent extraction process. Therefore, the extraction liquid is sprayed on the surface of the electromagnetic wave generator, so that the electromagnetic wave emitted by the electromagnetic wave generator can crack the protein raw material in the reaction solution to form the polypeptide; the protein solution is sprayed on the surface of the electromagnetic wave generator through the spray heads on the spray branch pipes after passing through a cooling system of the cooling box, and is circulated and refluxed for many times, so that the cracking of the protein is promoted while the electromagnetic wave generator is cooled, the molecular weight of the active peptide after cracking is reduced, the complete absorption of the active peptide by a human body is ensured, and the bioavailability of the human body is improved.
Referring to fig. 1 and 5, the extraction device 5 is disposed at the lower side of the box 1; one end of the extraction device 5 is spherically hinged with the first liquid discharge pipe 31, and the other end is provided with a transmission mechanism 6 for driving the bottom end of the extraction device 5 to rotate. Here, because the one end of extraction device and the spherical articulated of first drain pipe for the extraction device can be in the universal rotation of the tip of first drain pipe, the other end and the drive mechanism of extraction device are connected, and the bottom that drives the extraction device through drive mechanism is rotatory around the center pin of first drain pipe, so, helps mixing the further extraction of the mixed liquid in the extraction device to mix.
In this embodiment, connect extraction device 5 in the bottom of box 1, extraction device 5's size is little, well big, little down, because extraction device 5's top is articulated with first drain pipe, can drive extraction device's bottom through drive mechanism and take place to rock, helps extracting the mixture and the layering of liquid, simple structure, convenient to use.
Referring to fig. 5 and 7, a ball-shaped fixing member 311 is disposed at the bottom of the first liquid discharging pipe 31, and a liquid discharging passage is disposed in the ball-shaped fixing member 311; the top of the extraction device 5 is provided with a ball joint 51, and the ball fixing member 311 is disposed in the ball joint 51 and rotatably connected with the ball joint 51. Specifically, the spherical joint 51 comprises a spherical rotating seat 511 and a cover 512, the spherical rotating seat 511 is communicated with the extraction device 5; the cover 512 is sleeved on the first drainage tube 31 and is in threaded connection with the spherical rotating seat 511; the cover 512 and the spherical rotating base 511 are combined to form a rotating chamber, and the spherical fixing member 311 is disposed in the rotating chamber. Here, through the cooperation of spherical seat and lid of rotating, can form the rotation cavity that holds spherical mounting, spherical mounting can rotate at this rotation cavity, and can not break away from this rotation cavity to can realize the universal rotation of extraction device in first drain pipe bottom.
Referring to fig. 1, 5 and 6, a fixing bracket 7 is disposed at the lower side of the box body 1, a fixing plate 71 is disposed on the fixing bracket 7, and a fixing hole 711 is disposed on the fixing plate 71; the transmission mechanism 6 is disposed on the fixed plate 71. The transmission mechanism 6 includes: a rotating plate 61, a turbine turntable 62, a worm 63, a driving motor and a movable sleeve 65.
The rotating plate 61 is rotatably disposed on the fixing hole 711; a turbine turntable 62 is sleeved outside the rotating plate 61; the outer wall of the turbine rotor disk has a plurality of meshing teeth. The fixing holes on the fixing plate are stepped holes, and the turbine rotating disc is arranged on the upper layer hole position of the stepped holes.
The worm 63 is arranged on one side of the turbine turntable 62 and is meshed with the turbine turntable 62 in a tooth form; the worm is arranged transversely on one side of the fixing hole and is rotatably connected with the fixing plate. One side of the fixing hole is provided with an installation groove, and the worm is rotatably arranged in the installation groove. The middle section of the worm close to the turbine turntable is provided with meshing teeth, and the meshing teeth on the worm are meshed with the meshing teeth on the turbine turntable, so that the turbine turntable can rotate along with the rotation of the worm.
The driving motor 64 is disposed at one end of the worm 63 for driving the worm 63 to rotate. The driving motor is mainly used for providing power, is connected with one end of the worm, and can drive the worm to rotate along with the starting of the driving motor, so that the turbine turntable can be driven to rotate.
The movable sleeve 65 is eccentrically arranged on the rotating plate 61; the movable sleeve 65 is rotatably connected with the rotating plate 61 through a universal joint; the bottom of the extraction device 5 is provided with a second liquid discharge pipe 52, the second liquid discharge pipe 52 is arranged in the movable sleeve 65 in a penetrating way, and the upper end of the movable sleeve 65 is abutted against the extraction device 5. Here, be provided with the spheroid structure on the top outer wall of movable sleeve, the eccentric logical groove that is provided with on the rotor plate, the top that leads to the groove has the buckling parts of a kind of spheroid, and the ball block is passed through at the top that leads to the groove in the top of movable sleeve, and can be at the top free rotation that leads to the groove. The size of the through groove is larger than the outer diameter of the middle part of the movable sleeve, so that the movable sleeve can rotate in the through groove at a maximum angle. Of course, in order to further reduce the limitation of the through groove on the rotation of the movable sleeve, the bottom of the through groove can be provided with a horn-shaped opening, and the size of the opening end is gradually increased. The lower extreme of movable sleeve is provided with spacing portion for the movable sleeve can be in logical inslot scope free rotation, plays the effect that the restriction movable sleeve breaks away from logical groove. Of course, in other embodiments, the movable sleeve can also be directly arranged in the through groove of the rotating plate without the universal joint connection.
A plurality of L-shaped support rods 72 are arranged on the fixed support 7 around the extraction device 5, the vertical end of each L-shaped support rod 72 is fixedly connected with the fixed support 7, and the horizontal end of each L-shaped support rod 72 extends towards the extraction device 5; here, the vertical end of the L-shaped support bar is fixed to the fixing bracket by a bolt. The bottom of the horizontal end is provided with a chute.
The horizontal end of each L-shaped supporting plate 72 is slidably provided with a sliding block 73, and the top end of each sliding block is clamped in the sliding groove and is slidably connected with the sliding groove. The extraction device 5 is sleeved with a fixing ring 53, and a plurality of hinge blocks are arranged on the periphery of the fixing ring. The fixed ring 53 is clamped and fixed with the extraction device 5; the peripheral sides of the fixed rings 53 are hinged with connecting rods 54, one end of each connecting rod 54 is hinged with the corresponding sliding block 73, and the other end of each connecting rod 54 is hinged with the corresponding hinged block.
Along with the rotation of rotor plate, extraction device's bottom can be along with the rotation of rotor plate and be circular orbit and rock for polypeptide solution in the extraction device can the intensive mixing, improves extraction efficiency. And the whole body of the extraction device can also shake along with shaking, and through the matching of the connecting rod and the sliding block, one end of the extraction device can shake on the fixed support 7 stably, so that the stability of the extraction device in the operation process is improved.
Referring to fig. 3 and 4, a filter plate 24 having a plurality of filter holes is disposed on the liquid outlet of the reactor 2. Rotatably disposed on the filter plate 24 is a wiper blade assembly 25, the wiper blade assembly 25 comprising: a rotating ring 251 and a wiper blade 253.
The rotating ring 251 is rotatably arranged on a liquid outlet of the reactor 2, and a plurality of liquid inlet cavity pipes 252 are spirally arranged in the rotating ring 251; for example, the inner wall of the liquid outlet of the reactor 2 is provided with a limiting rotating groove, the outer wall of the rotating ring is provided with a limiting rotating block, and the limiting rotating block is clamped on the limiting rotating groove and can rotate along the limiting rotating groove. The rotating ring is provided with a plurality of liquid inlet cavity pipes which are spirally arranged along the flowing direction of the reaction solution. The number of inlet channels can preferably be 3 or 4.
With the first valve 26 on the outlet of the reactor 2 open, the reaction solution will pass through several inlet lumens and filter plates and into the cooling tank. Along with the flow of the reaction solution, the liquid inlet cavity pipe is spiral, and along with the flow of the reaction solution, the rotating ring can be driven to automatically rotate on the liquid outlet of the reactor.
The wiper 253 is vertically disposed at one end of the rotating ring 251 near the filter plate, and one end thereof abuts against the filter plate 24. The scraping blade is mainly arranged for scraping off protein raw materials and other sediments attached on the filter plate. Along with the rotation of rotating ring, can drive the doctor-bar and rotate, avoid the attachment on the filter to cause the jam to the liquid outlet of reactor.
Referring to fig. 1 to 2 again, a first valve 26 and a first flow rate detector 27 are disposed on the liquid outlet of the reactor 2; a second valve 32 and a second flow rate detector 33 are arranged on a liquid outlet of the cooling box 3; a liquid level detector 34 is arranged on the inner wall of the cooling box 3 along the longitudinal direction; the first drain pipe 31 is provided with a third valve 312; the top of the reactor 2 is provided with a feed inlet 28; a fourth valve 281 is provided at the feed port 28.
Referring to fig. 1 and 8, the apparatus further includes: and the microprocessor 8 is arranged outside the box body 1, and is used for receiving the liquid level value detected by the liquid level detector 34 and comparing the liquid level value with a first liquid level value and a second liquid level value of a set liquid level range, wherein the first liquid level value is smaller than the second liquid level value.
The microprocessor 8 is further configured to receive a first flow rate value detected by the first flow rate detector 27 and a second flow rate value detected by the second flow rate detector 33, and compare the first flow rate value with the second flow rate value.
In use, when the first valve 26 is opened and the liquid level value detected by the microprocessor 8 is equal to or greater than the first liquid level value, the second valve 32 and the liquid pump 4 are opened to circulate the cooling tank 3 and the reactor 2, and the first flow rate value is greater than the second flow rate value; the opening of the first valve and the second valve is controlled to control the magnitude of the first flow rate value and the second flow rate value. In the embodiment, the first flow rate value is controlled to be larger than the second flow rate value, so that after the protein raw material solution is acted by the electromagnetic wave generator 21, the protein chain is broken to form polypeptide, and the polypeptide is continuously degraded to finally form small molecular active polypeptide which has relatively small molecular weight and is suitable for absorption and is continuously accumulated in the cooling box.
When the level value detected by the microprocessor 8 is equal to or greater than the second level value, the first valve 26, the second valve 32 and the liquid pump 4 are closed, and the third valve 312 and the fourth valve 281 are simultaneously activated; so that the polypeptide solution in the cooling tank can flow into the extraction device through the third valve, and the protein raw material and other reaction solution for dissolving the protein raw material enter the reactor through the fourth valve. The continuous production of the active polypeptide can be realized by repeating the steps, and the production efficiency is improved.
In this embodiment, the apparatus further comprises: the power supply module is arranged outside the box body; the electromagnetic wave generator, the liquid pump and the microprocessor are all electrically connected with the power module and used for providing power.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. An active peptide extraction device, comprising:
the reactor comprises a box body (1), wherein a reactor (2) is arranged in the box body, and an electromagnetic wave generator (21) and a spraying branch pipe (22) are alternately arranged in the reactor (2); the bottom of the reactor (2) is provided with a buffer cavity (23), and one end of each spray branch pipe (22) extends into the buffer cavity (23);
the cooling tank (3) is arranged at the lower side of the reactor (2), and a liquid outlet of the cooling tank (3) is connected with a liquid inlet of the cache cavity (23) through a liquid pump (4); a liquid inlet of the cooling box (3) is connected with a liquid outlet of the reactor (2) through a pipeline; a first liquid discharge pipe (31) is arranged at the bottom of the cooling box (3);
the extraction device (5) is arranged at the lower side of the box body (1); one end of the extraction device (5) is spherically hinged with the first liquid discharge pipe (31), and the other end of the extraction device is provided with a transmission mechanism (6) for driving the bottom end of the extraction device (5) to rotate.
2. Active peptide extraction device according to claim 1, characterized in that the bottom of the first drain tube (31) is provided with a ball-shaped fixing member (311), and a drain channel is provided in the ball-shaped fixing member (311); the top of extraction device (5) is provided with spherical hinge (51), spherical mounting (311) set up in spherical hinge (51), and with spherical hinge (51) rotatable coupling.
3. Active peptide extraction device according to claim 2, characterized in that the spherical joint (51) comprises a spherical rotary seat (511) and a cover (512), the spherical rotary seat (511) communicating with the extraction device (5); the cover body (512) is sleeved on the first liquid discharging pipe (31) and is in threaded connection with the spherical rotating seat (511); the cover body (512) and the spherical rotating seat (511) are combined to form a rotating cavity, and the spherical fixing part (311) is arranged in the rotating cavity.
4. Active peptide extraction device according to claim 1, characterized in that the underside of the case (1) is provided with a fixing bracket (7), the fixing bracket (7) is provided with a fixing plate (71), and the fixing plate (71) is provided with a fixing hole (711);
the transmission mechanism (6) is arranged on the fixing plate (71); the transmission mechanism (6) comprises:
a rotating plate (61) rotatably provided on the fixing hole (711); a turbine turntable (62) is sleeved outside the rotating plate (61);
the worm (63) is arranged on one side of the turbine rotating disc (62) and is in tooth-shaped meshing with the turbine rotating disc (62);
the driving motor (64) is arranged at one end of the worm (63) and is used for driving the worm (63) to rotate;
a movable sleeve (65) eccentrically arranged on the rotating plate (61); the movable sleeve (65) is rotatably connected with the rotating plate (61) through a universal joint;
the bottom of the extraction device (5) is provided with a second liquid discharge pipe (52), the second liquid discharge pipe (52) penetrates through the movable sleeve (65), and the upper end of the movable sleeve (65) is abutted against the extraction device (5).
5. Active peptide extraction device according to claim 4, characterized in that a plurality of L-shaped support bars (72) are arranged on the fixed support (7) around the extraction device (5), the vertical end of each L-shaped support bar (72) is fixedly connected with the fixed support (7), and the horizontal end of each L-shaped support bar (72) extends towards the extraction device (5);
a sliding block (73) is slidably arranged at the horizontal end of each L-shaped supporting plate (72), a fixing ring (53) is sleeved on the extraction device (5), and the fixing ring (53) is clamped with the extraction device (5); the peripheral side of the fixed ring (53) is hinged with connecting rods (54), and one end of each connecting rod (54) is hinged with the corresponding sliding block (73).
6. Active peptide extraction device according to claim 1, characterized in that a filter plate (24) is arranged on the liquid outlet of the reactor (2), a wiper blade assembly (25) is rotatably arranged on the filter plate (24), the wiper blade assembly (25) comprising:
the rotating ring (251) is rotatably arranged on a liquid outlet of the reactor (2), and a plurality of liquid inlet cavity pipes (252) are spirally distributed in the rotating ring (251);
and the scraping blade (253) is vertically arranged at one end of the rotating ring (251), and one end of the scraping blade is abutted against the filter plate (24).
7. Active peptide extraction device according to claim 1, characterized in that the liquid outlet of the reactor (2) is provided with a first valve (26) and a first flow rate detector (27);
a second valve (32) and a second flow rate detector (33) are arranged on a liquid outlet of the cooling box (3); a liquid level detector (34) is arranged on the inner wall of the cooling box (3) along the longitudinal direction; a third valve (312) is arranged on the first liquid discharge pipe (31);
a feed inlet (28) is formed in the top of the reactor (2); and a fourth valve (281) is arranged on the feeding hole (28).
8. The active peptide extraction device of claim 7, further comprising:
the microprocessor (8) is arranged outside the box body (1) and used for receiving the liquid level value detected by the liquid level detector (34) and comparing the liquid level value with a first liquid level value and a second liquid level value of a set liquid level range, wherein the first liquid level value is smaller than the second liquid level value;
the microprocessor (8) is also used for receiving a first flow rate value detected by the first flow rate detector (27) and a second flow rate value detected by the second flow rate detector (33) and comparing the first flow rate value with the second flow rate value;
when the liquid level value detected by the microprocessor (8) is equal to or greater than the first liquid level value along with the opening of the first valve (26), the second valve (32) and the liquid pump (4) are opened to circulate the cooling tank (3) and the reactor (2) and enable the first flow rate value to be greater than the second flow rate value;
when the level value detected by the microprocessor (8) is equal to or greater than the second level value, the first valve (26), the second valve (32) and the liquid pump (4) are closed, and the third valve (312) and the fourth valve (281) are simultaneously activated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011542917.6A CN112521442B (en) | 2020-12-21 | 2020-12-21 | Active peptide extraction device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011542917.6A CN112521442B (en) | 2020-12-21 | 2020-12-21 | Active peptide extraction device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112521442A true CN112521442A (en) | 2021-03-19 |
| CN112521442B CN112521442B (en) | 2023-04-28 |
Family
ID=74976102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011542917.6A Active CN112521442B (en) | 2020-12-21 | 2020-12-21 | Active peptide extraction device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112521442B (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030010620A1 (en) * | 2001-07-03 | 2003-01-16 | University Of Alabama | Laser hydrolysis of polypeptides |
| US20050143313A1 (en) * | 2003-12-29 | 2005-06-30 | Henry Aoki | Novel peptide, method of production thereof, and pharmaceutical composition containing the same |
| CN103588859A (en) * | 2013-07-02 | 2014-02-19 | 牡丹江友搏药业股份有限公司 | Centipede active peptide and application thereof in pharmacy |
| CN103772481A (en) * | 2014-02-10 | 2014-05-07 | 孟祥军 | Continuous soybean active peptide extraction machine |
| CN207608509U (en) * | 2017-08-24 | 2018-07-13 | 北京泓九生物科技有限公司 | The device of vegetable protein cracking extraction polypeptide |
| CN108753886A (en) * | 2018-06-15 | 2018-11-06 | 黑龙江省野生动物研究所 | Deer bone active peptide extraction element and extracting method |
| CN111321189A (en) * | 2020-03-19 | 2020-06-23 | 成都六然医疗科技有限公司 | Cordyceps militaris polypeptide and preparation method thereof |
-
2020
- 2020-12-21 CN CN202011542917.6A patent/CN112521442B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030010620A1 (en) * | 2001-07-03 | 2003-01-16 | University Of Alabama | Laser hydrolysis of polypeptides |
| US20050143313A1 (en) * | 2003-12-29 | 2005-06-30 | Henry Aoki | Novel peptide, method of production thereof, and pharmaceutical composition containing the same |
| CN103588859A (en) * | 2013-07-02 | 2014-02-19 | 牡丹江友搏药业股份有限公司 | Centipede active peptide and application thereof in pharmacy |
| CN103772481A (en) * | 2014-02-10 | 2014-05-07 | 孟祥军 | Continuous soybean active peptide extraction machine |
| CN207608509U (en) * | 2017-08-24 | 2018-07-13 | 北京泓九生物科技有限公司 | The device of vegetable protein cracking extraction polypeptide |
| CN108753886A (en) * | 2018-06-15 | 2018-11-06 | 黑龙江省野生动物研究所 | Deer bone active peptide extraction element and extracting method |
| CN111321189A (en) * | 2020-03-19 | 2020-06-23 | 成都六然医疗科技有限公司 | Cordyceps militaris polypeptide and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 余娟;吴杨阳;章佳佳;蔡婷菡;方旭波;陈小娥;江旭华;: "微波膨化即食金枪鱼皮工艺条件的优化" * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112521442B (en) | 2023-04-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6605114B2 (en) | Container rotating device and container rotating device parts | |
| JP2017060952A (en) | Vessel rotary device | |
| CN112707490B (en) | Sewage treatment equipment and sewage treatment method for biomedical production | |
| CN213669779U (en) | Urban garden plants and administers device with soil remediation | |
| CN112521442A (en) | Active peptide extraction device | |
| CN111644137A (en) | Mixed reation kettle of pressure-sensitive collagen glue solution processing usefulness | |
| CN207996455U (en) | Ultrasonic-leaching device | |
| CN207369908U (en) | A kind of fish pond aerator | |
| CN209537500U (en) | Enzymolysis device is used in a kind of production of heparin sodium | |
| CN1025294C (en) | Process and installation for treatment of solid particle agglomerates suspended in liquid, in order to obtain heterogeneous mixture able to flow in long ducts without causing deposits | |
| CN216445023U (en) | Novel sewage treatment tank | |
| CN215234226U (en) | Titanium alloy reaction kettle | |
| CN109206174A (en) | A kind of agriculture and animal husbandry organic waste produces quick-acting liquid fertilizer devices | |
| CN212141547U (en) | Traditional chinese medicine composition is gathered and is used supersound extraction equipment | |
| CN207556963U (en) | A kind of intelligence soil digestion instrument | |
| CN215223697U (en) | Watering device for fruit planting | |
| CN112111382A (en) | High-efficient marsh gas fermentation system | |
| CN111729566A (en) | Pesticide mixes in farming and sprays integrative device | |
| CN220940648U (en) | A retort for preparation of blood cell albumen powder | |
| JP2004194528A (en) | Bubbling apparatus utilizing solar power generation | |
| CN211677477U (en) | Medical treatment internal medicine agitating unit | |
| CN221217207U (en) | Rotary slag scraping device for leather sewage treatment | |
| CN214764564U (en) | Separation and extraction reaction kettle for fish protein peptide | |
| CN220317527U (en) | Sterilizing device for aquaculture | |
| CN216879099U (en) | Diagnostic reagent's fluid reservoir of joining in marriage |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |