CN112521017A - Bioactive porous material and preparation method thereof - Google Patents
Bioactive porous material and preparation method thereof Download PDFInfo
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- CN112521017A CN112521017A CN202110043211.3A CN202110043211A CN112521017A CN 112521017 A CN112521017 A CN 112521017A CN 202110043211 A CN202110043211 A CN 202110043211A CN 112521017 A CN112521017 A CN 112521017A
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- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C11/00—Multi-cellular glass ; Porous or hollow glass or glass particles
- C03C11/007—Foam glass, e.g. obtained by incorporating a blowing agent and heating
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- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
- C03B19/00—Other methods of shaping glass
- C03B19/06—Other methods of shaping glass by sintering, e.g. by cold isostatic pressing of powders and subsequent sintering, by hot pressing of powders, by sintering slurries or dispersions not undergoing a liquid phase reaction
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C12/00—Powdered glass; Bead compositions
Abstract
The invention relates to the technical field of biomedical materials, in particular to a bioactive porous material and a preparation method thereof, wherein the bioactive porous material comprises the following raw materials in parts by mass: 65-75 parts of ethyl orthosilicate, 35-45 parts of calcium nitrate, 30-40 parts of triethyl phosphate, 6-8 parts of hydrochloric acid, 7-9 parts of modified pore-forming agent, 8-12 parts of polyvinyl alcohol and 7-13 parts of degradable additive, and the preparation method comprises the following steps: s1, preparing bioactive glass powder by combining a sol-gel method and acid catalysis, S2, mixing the bioactive glass powder, a modified pore-forming agent, polyvinyl alcohol and a degradable additive, oscillating, mixing uniformly, tabletting and forming to obtain a bioactive glass blank, and S3, calcining the bioactive glass blank, keeping the temperature, and removing the pore-forming agent to obtain the bioactive porous material. The invention can not only improve the pore-forming rate of the bioactive porous material, but also improve the biodegradation effect of the material.
Description
Technical Field
The invention relates to the technical field of biomedical materials, in particular to a bioactive porous material and a preparation method thereof.
Background
In recent years, the number of patients with bone defect in China is on the trend of increasing year by year, and the search for bone defect tissue repair materials is a key problem to be solved urgently in the field of orthopedic medical research. Bioactive porous materials are also widely used in this field to achieve better bone repair.
At present, bioactive glass is mostly used as a bioactive porous material, when the bioactive glass is implanted into a bone defect part, rapid ion exchange reaction occurs between the bioactive glass and body fluid, and a hydroxyapatite carbonate layer is formed on the surface of the bioactive glass, so that the material and bone are firmly and chemically bonded. The existing bioactive porous material has the phenomenon of low porosity in the using process, can affect the appearance required by cell growth, has certain inhibiting effect on vascularization ingrowth, and can affect the rate of compatibility between the material and bones due to the influence of the biodegradation capacity of the bioactive porous material. Therefore, we propose a bioactive porous material and a method for preparing the same to solve the above problems.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a bioactive porous material and a preparation method thereof.
The bioactive porous material comprises the following raw materials in parts by mass: 65-75 parts of ethyl orthosilicate, 35-45 parts of calcium nitrate, 30-40 parts of triethyl phosphate, 6-8 parts of hydrochloric acid, 7-9 parts of a modified pore-forming agent, 8-12 parts of polyvinyl alcohol and 7-13 parts of a degradable additive.
Preferably, the modified pore-forming agent is prepared from ammonium bicarbonate serving as a raw material, calcium chloride powder serving as an additive and a silane coupling agent KH 550.
Preferably, the modification process of the modified pore-forming agent is as follows: and (3) pouring calcium chloride powder into the ammonium bicarbonate, stirring uniformly, adding the silane coupling agent KH550, and continuously stirring until the materials are completely fused to obtain the modified pore-forming agent.
Preferably, the degradable additive is prepared from polyglycolic acid serving as a raw material, sodium alginate serving as an additive and a silane coupling agent KH 550.
Preferably, the preparation method of the degradable additive comprises the following steps: mixing polyglycolic acid and sodium alginate, stirring, adding silane coupling agent KH550, stirring, and mixing to obtain degradable additive.
The preparation method of the bioactive porous material comprises the following steps:
s1, preparing bioactive glass powder by combining a sol-gel method and acid catalysis;
s2, mixing the bioactive glass powder, the modified pore-forming agent, the polyvinyl alcohol and the degradable additive, oscillating, uniformly mixing, and tabletting to obtain a bioactive glass blank;
and S3, calcining the bioactive glass blank, keeping the temperature, and removing the pore-forming agent to obtain the bioactive porous material.
Preferably, the bioactive glass powder in S1 contains SiO2CaO and P2O5Wherein CaO: 45% -55% of P2O5：35%～45%、SiO2：0.1%～0.8%。
Preferably, the preparation process of the bioactive glass powder comprises the following steps: adding tetraethoxysilane, calcium nitrate, triethyl phosphate and hydrochloric acid into a beaker, stirring for 1 hour to prepare a uniform solution, aging for 72 hours at room temperature to fully perform hydrolysis-polycondensation reaction until gel is formed, placing the gel into an oven, drying for 72 hours and 48 hours at 70 ℃ and 150 ℃, respectively, carrying out heat treatment on the dried gel block in a box-type resistance furnace at 700 ℃ for 3 hours to prepare granular bioactive glass, grinding the granular bioactive glass in an agate mortar, sieving the granular bioactive glass with a 150-mesh sieve, and collecting powder with the granularity smaller than 150 meshes to obtain bioactive glass powder.
Preferably, the calcination temperature of the bioactive glass blank in the S3 is 800-1000 ℃, and the heat preservation time is 2-5 hours.
The invention has the beneficial effects that:
1. the method adds calcium chloride into the pore-forming agent ammonium bicarbonate, and blends and mixes the calcium chloride and the pore-forming agent ammonium bicarbonate through the coupling agent, so that the modified ammonium bicarbonate has certain moisture absorption capacity, promotes the decomposition of the modified ammonium bicarbonate into gas, and further improves the pore-forming rate.
2. According to the invention, polyglycolic acid is compounded and mixed with sodium alginate through a coupling agent to prepare the degradable additive, so that the capacity of the porous material is improved.
In conclusion, the invention can not only improve the pore-forming rate of the bioactive porous material, but also improve the biodegradation effect of the material.
Detailed Description
The present invention will be further illustrated with reference to the following specific examples.
The bioactive porous material comprises the following raw materials in parts by mass: 65-75 parts of ethyl orthosilicate, 35-45 parts of calcium nitrate, 30-40 parts of triethyl phosphate, 6-8 parts of hydrochloric acid, 7-9 parts of a modified pore-forming agent, 8-12 parts of polyvinyl alcohol and 7-13 parts of a degradable additive.
The modified pore-forming agent is prepared from ammonium bicarbonate serving as a raw material, calcium chloride powder serving as an additive and a silane coupling agent KH550, and the modification process comprises the following steps: and (3) pouring calcium chloride powder into the ammonium bicarbonate, stirring uniformly, adding the silane coupling agent KH550, and continuously stirring until the materials are completely fused to obtain the modified pore-forming agent.
In addition, the degradable additive is prepared by using polyglycolic acid as a raw material, sodium alginate as an additive and a silane coupling agent KH550, and the preparation method comprises the following steps: mixing polyglycolic acid and sodium alginate, stirring, adding silane coupling agent KH550, stirring, and mixing to obtain degradable additive.
The preparation method of the bioactive porous material comprises the following steps:
s1, preparing bioactive glass powder by combining a sol-gel method and acid catalysis;
s2, mixing the bioactive glass powder, the modified pore-forming agent, the polyvinyl alcohol and the degradable additive, oscillating, uniformly mixing, and tabletting to obtain a bioactive glass blank;
and S3, calcining the bioactive glass blank at 850 ℃, preserving heat for 3 hours, and removing the pore-forming agent to obtain the bioactive porous material.
Wherein the bioactive glass powder contains SiO2CaO and P2O5Wherein CaO: 45% of P2O5：35%、SiO2：0.6%；
In addition, the preparation process of the bioactive glass powder comprises the following steps: adding tetraethoxysilane, calcium nitrate, triethyl phosphate and hydrochloric acid into a beaker, stirring for 1 hour to prepare a uniform solution, aging for 72 hours at room temperature to fully perform hydrolysis-polycondensation reaction until gel is formed, placing the gel into an oven, drying for 72 hours and 48 hours at 70 ℃ and 150 ℃, respectively, carrying out heat treatment on the dried gel block in a box-type resistance furnace at 700 ℃ for 3 hours to prepare granular bioactive glass, grinding the granular bioactive glass in an agate mortar, sieving the granular bioactive glass with a 150-mesh sieve, and collecting powder with the granularity smaller than 150 meshes to obtain bioactive glass powder.
The first embodiment is as follows:
the bioactive porous material comprises the following raw materials in parts by mass: 65 parts of ethyl orthosilicate, 35 parts of calcium nitrate, 30 parts of triethyl phosphate, 6 parts of hydrochloric acid, 7 parts of modified pore-forming agent, 8 parts of polyvinyl alcohol and 7 parts of degradable additive.
Example two:
the bioactive porous material comprises the following raw materials in parts by mass: 70 parts of ethyl orthosilicate, 40 parts of calcium nitrate, 35 parts of triethyl phosphate, 7 parts of hydrochloric acid, 8 parts of modified pore-forming agent, 10 parts of polyvinyl alcohol and 10 parts of degradable additive.
Example three:
the bioactive porous material comprises the following raw materials in parts by mass: 75 parts of ethyl orthosilicate, 45 parts of calcium nitrate, 40 parts of triethyl phosphate, 8 parts of hydrochloric acid, 9 parts of modified pore-forming agent, 12 parts of polyvinyl alcohol and 13 parts of degradable additive.
In the first to third embodiments, the bioactive porous material is prepared by the following steps:
s1, preparing bioactive glass powder by combining a sol-gel method and acid catalysis;
s2, mixing the bioactive glass powder, the modified pore-forming agent, the polyvinyl alcohol and the degradable additive, oscillating, uniformly mixing, and tabletting to obtain a bioactive glass blank;
and S3, calcining the bioactive glass blank at 850 ℃, preserving heat for 3 hours, and removing the pore-forming agent to obtain the bioactive porous material.
Test one: determination of the porosity of the bioactive porous Material
Comparative example one:
the bioactive porous material comprises the following raw materials in parts by mass: 65 parts of ethyl orthosilicate, 35 parts of calcium nitrate, 30 parts of triethyl phosphate, 6 parts of hydrochloric acid, 8 parts of polyvinyl alcohol and 7 parts of degradable additive.
Comparative example two:
the bioactive porous material comprises the following raw materials in parts by mass: 70 parts of ethyl orthosilicate, 40 parts of calcium nitrate, 35 parts of triethyl phosphate, 7 parts of hydrochloric acid, 10 parts of polyvinyl alcohol and 10 parts of degradable additive.
Comparative example three:
the bioactive porous material comprises the following raw materials in parts by mass: 75 parts of ethyl orthosilicate, 45 parts of calcium nitrate, 40 parts of triethyl phosphate, 8 parts of hydrochloric acid, 12 parts of polyvinyl alcohol and 13 parts of degradable additive.
In each of the above comparative examples one to three, the bioactive porous material was prepared by the following steps:
s1, preparing bioactive glass powder by combining a sol-gel method and acid catalysis;
s2, mixing the bioactive glass powder, polyvinyl alcohol and degradable additive, oscillating, mixing uniformly, tabletting and forming to obtain a bioactive glass blank;
and S3, calcining the bioactive glass blank at 850 ℃, preserving heat for 3 hours, and removing the pore-forming agent to obtain the bioactive porous material.
Reference example one:
the bioactive porous material comprises the following raw materials in parts by mass: 65 parts of ethyl orthosilicate, 35 parts of calcium nitrate, 30 parts of triethyl phosphate, 6 parts of hydrochloric acid, 7 parts of pore-forming agent, 8 parts of polyvinyl alcohol and 7 parts of degradable additive.
Reference example two:
the bioactive porous material comprises the following raw materials in parts by mass: 70 parts of ethyl orthosilicate, 40 parts of calcium nitrate, 35 parts of triethyl phosphate, 7 parts of hydrochloric acid, 8 parts of pore-forming agent, 10 parts of polyvinyl alcohol and 10 parts of degradable additive.
Reference example three:
the bioactive porous material comprises the following raw materials in parts by mass: 75 parts of ethyl orthosilicate, 45 parts of calcium nitrate, 40 parts of triethyl phosphate, 8 parts of hydrochloric acid, 9 parts of pore-forming agent, 12 parts of polyvinyl alcohol and 13 parts of degradable additive.
In the first to third reference examples, the pore-forming agent is only ammonium bicarbonate monomer, and the bioactive porous material is prepared by the following steps:
s1, preparing bioactive glass powder by combining a sol-gel method and acid catalysis;
s2, mixing the bioactive glass powder, the pore-forming agent, the polyvinyl alcohol and the degradable additive, oscillating, uniformly mixing, tabletting and forming to obtain a bioactive glass blank;
and S3, calcining the bioactive glass blank at 850 ℃, preserving heat for 3 hours, and removing the pore-forming agent to obtain the bioactive porous material.
Taking the porous materials in the first to third examples, the first to third comparative examples and the first to third reference examples, one surface of the porous material is processed in a grinding and polishing mode until a horizontal section is formed, and then the porous material is sequentially placed under a microscope to observe the total area S (cm) of the horizontal section2) And the area S of the pores contained thereinHole(s)（cm2) The area is rounded and the porosity (%) of this section is calculated by the following formula and is reported in the following table:
from the data in the above table, the porosity of the bioactive porous material is, from high to low, in the order of example > reference example > comparative example, that is, the porosity of the material can be improved by adding a proper pore-forming agent, and compared with the examples and reference examples, it can be found that the final porosity of the modified pore-forming agent is higher than that of the unmodified pore-forming agent, that is, the pore-forming effect of the modified pore-forming agent is better.
And (2) test II: determination of biodegradability of the bioactive porous Material
Comparative example four:
the bioactive porous material comprises the following raw materials in parts by mass: 65 parts of ethyl orthosilicate, 35 parts of calcium nitrate, 30 parts of triethyl phosphate, 6 parts of hydrochloric acid, 7 parts of a modified pore-forming agent and 8 parts of polyvinyl alcohol.
Comparative example five:
the bioactive porous material comprises the following raw materials in parts by mass: 70 parts of ethyl orthosilicate, 40 parts of calcium nitrate, 35 parts of triethyl phosphate, 7 parts of hydrochloric acid, 8 parts of modified pore-forming agent and 10 parts of polyvinyl alcohol.
Comparative example six:
the bioactive porous material comprises the following raw materials in parts by mass: 75 parts of ethyl orthosilicate, 45 parts of calcium nitrate, 40 parts of triethyl phosphate, 8 parts of hydrochloric acid, 9 parts of a modified pore-forming agent and 12 parts of polyvinyl alcohol.
In each of the above comparative examples four to six, the bioactive porous material was prepared by the following steps:
s1, preparing bioactive glass powder by combining a sol-gel method and acid catalysis;
s2, mixing the bioactive glass powder, polyvinyl alcohol and a modified pore-forming agent, oscillating, uniformly mixing, and tabletting to obtain a bioactive glass blank;
and S3, calcining the bioactive glass blank at 850 ℃, preserving heat for 3 hours, and removing the pore-forming agent to obtain the bioactive porous material.
Reference example four:
the bioactive porous material comprises the following raw materials in parts by mass: 65 parts of ethyl orthosilicate, 35 parts of calcium nitrate, 30 parts of triethyl phosphate, 6 parts of hydrochloric acid, 7 parts of modified pore-forming agent, 8 parts of polyvinyl alcohol and 7 parts of degradable additive.
Reference example five:
the bioactive porous material comprises the following raw materials in parts by mass: 70 parts of ethyl orthosilicate, 40 parts of calcium nitrate, 35 parts of triethyl phosphate, 7 parts of hydrochloric acid, 8 parts of modified pore-forming agent, 10 parts of polyvinyl alcohol and 10 parts of degradable additive.
Reference example six:
the bioactive porous material comprises the following raw materials in parts by mass: 75 parts of ethyl orthosilicate, 45 parts of calcium nitrate, 40 parts of triethyl phosphate, 8 parts of hydrochloric acid, 9 parts of modified pore-forming agent, 12 parts of polyvinyl alcohol and 13 parts of degradable additive.
In the fourth reference example to the sixth reference example, the degradable additives are polyglycolic acid monomers, and the bioactive porous material is prepared by the following steps:
s1, preparing bioactive glass powder by combining a sol-gel method and acid catalysis;
s2, mixing the bioactive glass powder, the modified pore-forming agent, the polyvinyl alcohol and the degradable additive, oscillating, uniformly mixing, and tabletting to obtain a bioactive glass blank;
and S3, calcining the bioactive glass blank at 850 ℃, preserving heat for 3 hours, and removing the pore-forming agent to obtain the bioactive porous material.
The porous materials in the first to third examples, the fourth to sixth comparative examples and the fourth to sixth reference examples were taken, placed in beakers respectively, and the prepared SBF simulant body fluid (the SBF simulant body fluid mainly consists of sodium chloride, potassium chloride, dipotassium hydrogen phosphate, magnesium chloride, calcium chloride, Tris, sodium bicarbonate, etc., and is subjected to aseptic treatment, pH = 7.4) was poured into the beakers, so that the porous materials were completely immersed in the simulant body fluid, the time for complete degradation of the porous materials in the simulant body fluid was observed, and recorded in the following table:
from the above data, it can be seen that the time for the bioactive porous material in the examples to biodegrade in the human body is the shortest, and the bioactive porous material in the reference example is the bioactive porous material in the comparative example, that is, the appropriate addition of the degradable additive can improve the biodegradability of the material, thereby increasing the compatibility rate of the bioactive porous material in the human body, and as for the examples and the reference example, it can be found that the biodegradable additive after being compounded can further improve the biodegradability of the porous material.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (9)
1. The bioactive porous material is characterized by comprising the following raw materials in parts by mass: 65-75 parts of ethyl orthosilicate, 35-45 parts of calcium nitrate, 30-40 parts of triethyl phosphate, 6-8 parts of hydrochloric acid, 7-9 parts of a modified pore-forming agent, 8-12 parts of polyvinyl alcohol and 7-13 parts of a degradable additive.
2. The bioactive porous material according to claim 1, characterized in that the modified pore-forming agent is prepared from ammonium bicarbonate as a raw material, calcium chloride powder as an additive and a silane coupling agent KH 550.
3. The bioactive porous material of claim 2, wherein the modified pore-forming agent is modified by the following process: and (3) pouring calcium chloride powder into the ammonium bicarbonate, stirring uniformly, adding the silane coupling agent KH550, and continuously stirring until the materials are completely fused to obtain the modified pore-forming agent.
4. The bioactive porous material according to claim 1, wherein the degradable additive is prepared from polyglycolic acid as a raw material, sodium alginate as an additive and a silane coupling agent KH 550.
5. The bioactive porous material of claim 4, wherein the degradable additive is prepared by a method comprising: mixing polyglycolic acid and sodium alginate, stirring, adding silane coupling agent KH550, stirring, and mixing to obtain degradable additive.
6. The preparation method of the bioactive porous material is characterized by comprising the following steps:
s1, preparing bioactive glass powder by combining a sol-gel method and acid catalysis;
s2, mixing the bioactive glass powder, the modified pore-forming agent, the polyvinyl alcohol and the degradable additive, oscillating, uniformly mixing, and tabletting to obtain a bioactive glass blank;
and S3, calcining the bioactive glass blank, keeping the temperature, and removing the pore-forming agent to obtain the bioactive porous material.
7. The method for preparing a bioactive porous material according to claim 6, wherein the bioactive glass powder in S1 contains SiO2CaO and P2O5Wherein CaO: 45% -55% of P2O5：35%～45%、SiO2：0.1%～0.8%。
8. The method for preparing a bioactive porous material according to claim 6, wherein the preparation process of the bioactive glass powder is as follows: adding tetraethoxysilane, calcium nitrate, triethyl phosphate and hydrochloric acid into a beaker, stirring for 1 hour to prepare a uniform solution, aging for 72 hours at room temperature to fully perform hydrolysis-polycondensation reaction until gel is formed, placing the gel into an oven, drying for 72 hours and 48 hours at 70 ℃ and 150 ℃, respectively, carrying out heat treatment on the dried gel block in a box-type resistance furnace at 700 ℃ for 3 hours to prepare granular bioactive glass, grinding the granular bioactive glass in an agate mortar, sieving the granular bioactive glass with a 150-mesh sieve, and collecting powder with the granularity smaller than 150 meshes to obtain bioactive glass powder.
9. The method for preparing a bioactive porous material according to claim 6, wherein the calcination temperature of the bioactive glass blank in S3 is 800-1000 ℃, and the heat preservation time is 2-5 hours.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115317436A (en) * | 2022-10-14 | 2022-11-11 | 广州优理氏生物科技有限公司 | Composition with mild whitening and freckle removing effects and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101091805A (en) * | 2006-06-20 | 2007-12-26 | 华东理工大学 | Lumpish biologic bracket material with diplopore and preparation method |
| CN102503538A (en) * | 2011-11-02 | 2012-06-20 | 浙江大学 | Continuously pore-forming silicon carbide ceramic material and preparation method for same |
| CN106397843A (en) * | 2016-08-31 | 2017-02-15 | 安徽奥斯博医疗仪器设备有限公司 | Polyhydroxybutyrate-based degradable 3D printing consumables |
| CN106904995A (en) * | 2017-02-24 | 2017-06-30 | 玉林龙升建筑装饰工程有限公司 | One kind can damping ceramic tile and preparation method thereof |
| CN108144113A (en) * | 2018-02-12 | 2018-06-12 | 华南理工大学 | A kind of porous bone repair material of bioactivity glass and preparation method thereof |
-
2021
- 2021-01-13 CN CN202110043211.3A patent/CN112521017A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101091805A (en) * | 2006-06-20 | 2007-12-26 | 华东理工大学 | Lumpish biologic bracket material with diplopore and preparation method |
| CN102503538A (en) * | 2011-11-02 | 2012-06-20 | 浙江大学 | Continuously pore-forming silicon carbide ceramic material and preparation method for same |
| CN106397843A (en) * | 2016-08-31 | 2017-02-15 | 安徽奥斯博医疗仪器设备有限公司 | Polyhydroxybutyrate-based degradable 3D printing consumables |
| CN106904995A (en) * | 2017-02-24 | 2017-06-30 | 玉林龙升建筑装饰工程有限公司 | One kind can damping ceramic tile and preparation method thereof |
| CN108144113A (en) * | 2018-02-12 | 2018-06-12 | 华南理工大学 | A kind of porous bone repair material of bioactivity glass and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115317436A (en) * | 2022-10-14 | 2022-11-11 | 广州优理氏生物科技有限公司 | Composition with mild whitening and freckle removing effects and application thereof |
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