CN112515258A - Pocket-insertion type mask - Google Patents
Pocket-insertion type mask Download PDFInfo
- Publication number
- CN112515258A CN112515258A CN202011186440.2A CN202011186440A CN112515258A CN 112515258 A CN112515258 A CN 112515258A CN 202011186440 A CN202011186440 A CN 202011186440A CN 112515258 A CN112515258 A CN 112515258A
- Authority
- CN
- China
- Prior art keywords
- antiviral
- cross
- mask
- fiber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000003780 insertion Methods 0.000 title claims abstract description 22
- 239000002121 nanofiber Substances 0.000 claims abstract description 85
- 239000012528 membrane Substances 0.000 claims abstract description 54
- 230000000840 anti-viral effect Effects 0.000 claims abstract description 48
- 239000000463 material Substances 0.000 claims abstract description 43
- 238000010041 electrostatic spinning Methods 0.000 claims abstract description 32
- 239000003443 antiviral agent Substances 0.000 claims abstract description 28
- 239000002131 composite material Substances 0.000 claims abstract description 21
- 238000004132 cross linking Methods 0.000 claims abstract description 16
- 239000000835 fiber Substances 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims abstract description 11
- 239000002861 polymer material Substances 0.000 claims abstract description 10
- 230000037431 insertion Effects 0.000 claims abstract description 4
- 239000003431 cross linking reagent Substances 0.000 claims description 26
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 14
- 239000004745 nonwoven fabric Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 238000003825 pressing Methods 0.000 claims description 10
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 10
- 238000009987 spinning Methods 0.000 claims description 10
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 9
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 9
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 8
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 8
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- 239000004743 Polypropylene Substances 0.000 claims description 6
- 239000012456 homogeneous solution Substances 0.000 claims description 6
- -1 polypropylene Polymers 0.000 claims description 6
- 229920001155 polypropylene Polymers 0.000 claims description 6
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 5
- 239000008367 deionised water Substances 0.000 claims description 5
- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 5
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 claims description 4
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 4
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 claims description 4
- NQDJXKOVJZTUJA-UHFFFAOYSA-N nevirapine Chemical compound C12=NC=CC=C2C(=O)NC=2C(C)=CC=NC=2N1C1CC1 NQDJXKOVJZTUJA-UHFFFAOYSA-N 0.000 claims description 4
- 238000002791 soaking Methods 0.000 claims description 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
- 108010010803 Gelatin Proteins 0.000 claims description 3
- 239000002033 PVDF binder Substances 0.000 claims description 3
- 229920002301 cellulose acetate Polymers 0.000 claims description 3
- 229920000159 gelatin Polymers 0.000 claims description 3
- 239000008273 gelatin Substances 0.000 claims description 3
- 235000019322 gelatine Nutrition 0.000 claims description 3
- 235000011852 gelatine desserts Nutrition 0.000 claims description 3
- 229920002492 poly(sulfone) Polymers 0.000 claims description 3
- 229920002239 polyacrylonitrile Polymers 0.000 claims description 3
- 239000004632 polycaprolactone Substances 0.000 claims description 3
- 229920001610 polycaprolactone Polymers 0.000 claims description 3
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims description 3
- 235000010413 sodium alginate Nutrition 0.000 claims description 3
- 239000000661 sodium alginate Substances 0.000 claims description 3
- 229940005550 sodium alginate Drugs 0.000 claims description 3
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- GNMGAVKSZFQCDD-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate;3-hydroxypropyl prop-2-enoate Chemical compound OCCOC(=O)C=C.OCCCOC(=O)C=C GNMGAVKSZFQCDD-UHFFFAOYSA-N 0.000 claims description 2
- AEUAEICGCMSYCQ-UHFFFAOYSA-N 4-n-(7-chloroquinolin-1-ium-4-yl)-1-n,1-n-diethylpentane-1,4-diamine;dihydrogen phosphate Chemical compound OP(O)(O)=O.ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 AEUAEICGCMSYCQ-UHFFFAOYSA-N 0.000 claims description 2
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims description 2
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims description 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 2
- CNCOEDDPFOAUMB-UHFFFAOYSA-N N-Methylolacrylamide Chemical compound OCNC(=O)C=C CNCOEDDPFOAUMB-UHFFFAOYSA-N 0.000 claims description 2
- 239000004793 Polystyrene Substances 0.000 claims description 2
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 claims description 2
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 claims description 2
- 229960004191 artemisinin Drugs 0.000 claims description 2
- 229930101531 artemisinin Natural products 0.000 claims description 2
- 229960002328 chloroquine phosphate Drugs 0.000 claims description 2
- CJBJHOAVZSMMDJ-HEXNFIEUSA-N darunavir Chemical compound C([C@@H]([C@H](O)CN(CC(C)C)S(=O)(=O)C=1C=CC(N)=CC=1)NC(=O)O[C@@H]1[C@@H]2CCO[C@@H]2OC1)C1=CC=CC=C1 CJBJHOAVZSMMDJ-HEXNFIEUSA-N 0.000 claims description 2
- 229960005107 darunavir Drugs 0.000 claims description 2
- GYZLOYUZLJXAJU-UHFFFAOYSA-N diglycidyl ether Chemical compound C1OC1COCC1CO1 GYZLOYUZLJXAJU-UHFFFAOYSA-N 0.000 claims description 2
- 229960004396 famciclovir Drugs 0.000 claims description 2
- GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 claims description 2
- 229940015043 glyoxal Drugs 0.000 claims description 2
- JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 claims description 2
- 229960001627 lamivudine Drugs 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- OMNKZBIFPJNNIO-UHFFFAOYSA-N n-(2-methyl-4-oxopentan-2-yl)prop-2-enamide Chemical compound CC(=O)CC(C)(C)NC(=O)C=C OMNKZBIFPJNNIO-UHFFFAOYSA-N 0.000 claims description 2
- 229960000689 nevirapine Drugs 0.000 claims description 2
- 239000004626 polylactic acid Substances 0.000 claims description 2
- 229920001451 polypropylene glycol Polymers 0.000 claims description 2
- 239000004800 polyvinyl chloride Substances 0.000 claims description 2
- 239000009254 shuang-huang-lian Substances 0.000 claims description 2
- 239000004695 Polyether sulfone Substances 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920006393 polyether sulfone Polymers 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 229920000915 polyvinyl chloride Polymers 0.000 claims 1
- 238000001914 filtration Methods 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 5
- 239000000654 additive Substances 0.000 abstract description 2
- 230000000996 additive effect Effects 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 11
- 241000700605 Viruses Species 0.000 description 10
- 239000000443 aerosol Substances 0.000 description 9
- 239000002245 particle Substances 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 238000003756 stirring Methods 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 230000004083 survival effect Effects 0.000 description 5
- 241000712431 Influenza A virus Species 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 239000004744 fabric Substances 0.000 description 4
- 238000011056 performance test Methods 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 238000012876 topography Methods 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 239000013504 Triton X-100 Substances 0.000 description 3
- 229920004890 Triton X-100 Polymers 0.000 description 3
- 238000006136 alcoholysis reaction Methods 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920012266 Poly(ether sulfone) PES Polymers 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D13/00—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches
- A41D13/05—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches protecting only a particular body part
- A41D13/11—Protective face masks, e.g. for surgical use, or for use in foul atmospheres
- A41D13/1192—Protective face masks, e.g. for surgical use, or for use in foul atmospheres with antimicrobial agent
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D27/00—Details of garments or of their making
- A41D27/20—Pockets; Making or setting-in pockets
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D31/00—Materials specially adapted for outerwear
- A41D31/02—Layered materials
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D31/00—Materials specially adapted for outerwear
- A41D31/04—Materials specially adapted for outerwear characterised by special function or use
- A41D31/10—Impermeable to liquids, e.g. waterproof; Liquid-repellent
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D31/00—Materials specially adapted for outerwear
- A41D31/04—Materials specially adapted for outerwear characterised by special function or use
- A41D31/30—Antimicrobial, e.g. antibacterial
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties
- D01F1/103—Agents inhibiting growth of microorganisms
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
- D01F6/44—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds as major constituent with other polymers or low-molecular-weight compounds
- D01F6/50—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds as major constituent with other polymers or low-molecular-weight compounds of polyalcohols, polyacetals or polyketals
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
- D04H1/4382—Stretched reticular film fibres; Composite fibres; Mixed fibres; Ultrafine fibres; Fibres for artificial leather
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
- D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
- D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M11/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising
- D06M11/07—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with halogens; with halogen acids or salts thereof; with oxides or oxyacids of halogens or salts thereof
- D06M11/11—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with halogens; with halogen acids or salts thereof; with oxides or oxyacids of halogens or salts thereof with halogen acids or salts thereof
- D06M11/13—Ammonium halides or halides of elements of Groups 1 or 11 of the Periodic Table
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
- D06M13/12—Aldehydes; Ketones
- D06M13/123—Polyaldehydes; Polyketones
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D2300/00—Details of garments
- A41D2300/20—Inserts
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D2400/00—Functions or special features of garments
- A41D2400/70—Removability
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M2101/00—Chemical constitution of the fibres, threads, yarns, fabrics or fibrous goods made from such materials, to be treated
- D06M2101/16—Synthetic fibres, other than mineral fibres
- D06M2101/18—Synthetic fibres consisting of macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
- D06M2101/24—Polymers or copolymers of alkenylalcohols or esters thereof; Polymers or copolymers of alkenylethers, acetals or ketones
Landscapes
- Engineering & Computer Science (AREA)
- Textile Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Respiratory Apparatuses And Protective Means (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a pocket-insertion type mask which has a three-layer composite structure, wherein an inner layer and an outer layer are connected to form a pocket, and a middle layer is an insertion piece which can be pulled out of the pocket; the middle layer is made of an antiviral medical nano-fiber mask material, the average diameter of the fiber is 100-500 nm, and the filtering effect is achieved, and the preparation method comprises the following steps: preparing the electrostatic spinning solution containing the polymer material and the antiviral drug into a nanofiber membrane, and performing cross-linking treatment on the nanofiber membrane to obtain the antiviral medical nanofiber mask material. The invention takes the antiviral drug with low price and wide source as the additive, prepares the novel antiviral medical nano-fiber mask material by an electrostatic spinning method, and inserts the novel antiviral medical nano-fiber mask material into the oral pocket as the removable insert to obtain the mask with novel structure.
Description
Technical Field
The invention belongs to the technical field of masks, and relates to a pocket-insertion type mask.
Background
At present, masks used in the process of resisting viruses achieve the protection effect by a method for isolating viruses, and the masks mainly have the isolation effect, namely active carbon, nano fibers or N95 non-woven fabrics. These masks are frequently replaced, and since viruses adsorbed on the masks may become a new pollution source, the masks are inefficient to use and require mass production, and such discarded masks generally require harmless treatment and also put some pressure on garbage disposal. The raw materials for preparing the mask comprise non-woven fabrics, N95 cloth and nano fibers, and the antibacterial or antiviral property of the mask is to add antibacterial or antiviral drugs into the cloth. In recent years, researchers mostly finish antiviral drugs such as metal ions and metal oxides on the surface of the fabric by a surface finishing method to endow the fabric with antiviral properties, the method is complex, and the protective effect and the lasting performance of the prepared mask are to be further improved.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides a pocket-insertion type mask, wherein the middle layer of the mask can be pulled away, and is an antiviral medical nano-fiber mask material which is prepared by taking an antiviral drug with low price and wide source as an additive through an electrostatic spinning method.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
a pocket-plug-in type mask has a three-layer composite structure, wherein an inner layer and an outer layer are connected to form a pocket, and a middle layer is a plug-in piece which can be pulled out of the pocket; the middle layer is made of an antiviral medical nano-fiber mask material, the average diameter of the fiber is 100-500 nm, and the filtering effect is achieved, and the preparation method comprises the following steps: preparing the electrostatic spinning solution containing the polymer material and the antiviral drug into a nanofiber membrane, and performing cross-linking treatment on the nanofiber membrane to obtain the antiviral medical nanofiber mask material.
As a preferred technical scheme:
the polymer material is a modified polymer of X or X, which is non-toxic and harmless, and the nanofiber membrane loaded with the antiviral drug can be prepared by electrostatic spinning, specifically, X is polyvinyl alcohol (PVA), Cellulose Acetate (CA), polyvinylidene fluoride (PVDF), Polysulfone (PSU), Polystyrene (PS), polyvinyl chloride (PVC), Polycaprolactone (PCL), polylactic acid (PLA), Sodium Alginate (SA), Gelatin (GE), Polyacrylonitrile (PAN) or polyether sulfone (PES).
According to the pocket-insertion type mask, the antiviral drug is a commonly used antiviral drug in current reports, and specifically is more than one of organosilicon quaternary ammonium salt, Reidevir, Abidol, Darunavir, Shuanghuanglian oral liquid, chloroquine phosphate, artemisinin, lamivudine, famciclovir and nevirapine.
The preparation method of the pocket-insertion type mask, the antiviral medical nano-fiber mask material, comprises the following steps:
(1) dissolving a polymer material in a solvent I to prepare a first uniform solution;
(2) dissolving an antiviral drug in the first uniform solution obtained in the step (1) to obtain an electrostatic spinning solution;
(3) carrying out electrostatic spinning on the electrostatic spinning solution obtained in the step (2) to obtain nanofiber non-woven fabrics, and carrying out cold pressing treatment to enhance the mechanical property of the nanofiber non-woven fabrics so as to obtain a nanofiber membrane with a flat surface;
(4) mixing hydrochloric acid in a solvent II to prepare a second uniform solution;
(5) mixing a cross-linking agent in the second uniform solution obtained in the step (4) to obtain a cross-linking agent solution;
(6) soaking the nanofiber membrane obtained in the step (3) into the cross-linking agent solution obtained in the step (5) for cross-linking treatment to obtain a composite membrane;
(7) rinsing the composite membrane obtained in the step (6) by using deionized water to obtain the antiviral medical nano fiber mask material.
In the above pocket-insert mask, in the step (1), the solvent I is one or more of water, acetamide, N-dimethylethanol, N-dimethylformamide, isopropanol, N-butanol, acetone, 1, 4-dioxane, tetrahydrofuran, acetic acid, dichloromethane and chloroform; the concentration of the first homogeneous solution is 6-25 wt%; in the step (2), the concentration of the antiviral drug in the electrostatic spinning solution is 5-48.4 wt%.
In the above pocket-insertion type mask, in the step (3), the electrostatic spinning process parameters are as follows: the voltage is 5-25 kV, the aperture of a nozzle is 0.2-3 mm, the flow rate of a solution is 2-30 mu L/min, the temperature of a spinning environment is 15-50 ℃, the relative humidity of the spinning environment is 40-60%, the receiving distance is 10-20 cm, and the rotating speed of a receiving roller is 300-800 r/min; the pressure of cold pressing treatment is 2-8 MPa, and the time is 10-40 s; the thickness of the nanofiber membrane is 10-40 mu m, the porosity is 45% -80%, and the air permeability of the membrane material is increased to the maximum extent on the premise of ensuring the separation efficiency.
In the above pocket-insert mask, in the step (4), the solvent II is one or more of water, acetamide, N-dimethylethanol, N-dimethylformamide, isopropanol, N-butanol, acetone, 1, 4-dioxane, tetrahydrofuran, acetic acid, dichloromethane, and chloroform; the concentration of the second homogeneous solution is 0.2-1 wt%.
In the above pocket-insert type mask, in the step (5), the cross-linking agent is one or more selected from glutaraldehyde, glyoxal, acrylic acid, hydroxyethyl acrylate hydroxypropyl acrylate, methacrylic acid, divinylbenzene, N-methylol acrylamide, diacetone acrylamide, hydroxyethyl methacrylate, trimethylolpropane, polypropylene glycol glycidyl ether, aziridine and acrylonitrile; the concentration of the cross-linking agent in the cross-linking agent solution is 1-5 wt%.
According to the pocket-insertion type mask, in the step (6), the mass ratio of the nanofiber membrane to the cross-linking agent solution is 1-5: 50-200, so that the nanofiber membrane is fully cross-linked; the temperature of the cross-linking treatment is 15-35 ℃, and the time is 1-4 h.
The pocket-insertion type mask comprises an inner layer and an outer layer which are made of polypropylene non-woven fabrics, the average diameter of fibers is 10-50 mu m, and the pocket-insertion type mask has a water blocking effect and prevents spray from entering or penetrating out of the mask.
The mask is designed into a pocket-insertion type structure, the inner layer and the outer layer are made of polypropylene non-woven fabrics, the average diameter of fibers is 10-50 mu m, the water blocking effect is achieved, flying foam is prevented from entering or penetrating out of the mask, the middle layer is made of an antiviral medical nano-fiber mask material, the insertion piece which can be pulled out of the insertion pocket can be used repeatedly, when viruses are attached to the antiviral medical nano-fiber mask material, proliferation is inhibited, further apoptosis is avoided, virus diffusion is avoided, safety of doctors is protected, in addition, the average diameter of the fibers of the middle layer is 100-500 nm, and pm2.5 and virus and bacteria can be blocked by the high specific surface area and fine grids of the nano fibers.
Has the advantages that:
(1) the nanofiber membrane is prepared by adopting an electrostatic spinning method and is used as a main body material of the middle layer of the mask, the nanofiber membrane has higher specific surface area and porosity and a mutually-penetrated pore structure, and the air permeability of the nanofiber membrane is greatly improved on the premise of ensuring the entrapment efficiency of the membrane material;
(2) the nano-fiber membrane (namely the main material of the middle layer of the mask) is loaded with the antiviral drug, so that virus and bacteria proliferated on the mask can be inhibited in the using process, the virus diffusion is effectively avoided, and the safety of doctors is protected;
(3) the mask is of a pocket-insertion type structure, and the middle layer can be repeatedly used, so that the application efficiency of the mask is improved;
(4) the preparation method of the antiviral medical nano-fiber mask material is simple and feasible, and the high-efficiency antiviral medical mask material can be prepared by optimizing antiviral drugs, so that the large-scale production is easy to realize.
Drawings
FIG. 1 is a surface SEM topography (a) and a physical map (b) of a composite membrane of comparative example 1;
FIG. 2 is a surface SEM topography (a) and physical map (b) of the composite film of example 2.
Detailed Description
The invention will be further illustrated with reference to specific embodiments. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Further, it should be understood that various changes or modifications of the present invention may be made by those skilled in the art after reading the teaching of the present invention, and such equivalents may fall within the scope of the present invention as defined in the appended claims.
Example 1
A pocket-plug type mask has a three-layer composite structure, including an inner layer, a middle layer and an outer layer;
the inner layer and the outer layer are polypropylene non-woven fabrics which are connected to form a pocket, and the average diameter of the fiber is 50 μm;
the middle layer is an inserting piece which can be pulled out from the inserting pocket; the middle layer is made of an antiviral medical nano-fiber mask material, the average diameter of the fiber is 230nm, and the preparation method comprises the following steps: preparing an electrostatic spinning solution containing both a polymer material and an antiviral drug into a nanofiber membrane, and then performing cross-linking treatment on the nanofiber membrane to obtain an antiviral medical nanofiber mask material;
the preparation method of the antiviral medical nano-fiber mask material comprises the following specific steps:
(1) a polymer polyvinyl alcohol (PVA) (Mw 146000, alcoholysis degree 99%) was dissolved in water, and stirred at 95 ℃ for 12 hours to prepare a first homogeneous solution with a concentration of 9.75 wt%;
(2) dissolving a drop of nonionic surfactant Triton X-100 and an antiviral drug organosilicon quaternary ammonium salt in the first uniform solution obtained in the step (1) to obtain an electrostatic spinning solution; wherein the concentration of organosilicon quaternary ammonium salt as antiviral drug is 12.2 wt%
(3) Carrying out electrostatic spinning on the electrostatic spinning solution obtained in the step (2) to obtain nanofiber non-woven fabric, and carrying out cold pressing treatment to obtain a nanofiber membrane;
wherein the technological parameters of electrostatic spinning are as follows: the voltage is 15kV, the orifice diameter is 0.7mm, the solution flow rate is 12.0 mu L/min, the temperature of the spinning environment is 25 ℃, the relative humidity of the spinning environment is 40%, the receiving distance is 15cm, and the rotating speed of the receiving roller is 600 r/min; the pressure of the cold pressing treatment is 4MPa, and the time is 20 s; the thickness of the nanofiber membrane is 20 μm, and the porosity is 70%;
(4) mixing hydrochloric acid in acetone to prepare a second uniform solution with the concentration of 0.23 wt%;
(5) mixing a cross-linking agent glutaraldehyde in the second uniform solution obtained in the step (4), and stirring at room temperature for 10min to obtain a cross-linking agent solution with the concentration of 1.9 wt%;
(6) soaking the nanofiber membrane obtained in the step (3) into the cross-linking agent solution obtained in the step (5) for cross-linking treatment to obtain a composite membrane; wherein the mass ratio of the nanofiber membrane to the cross-linking agent solution is 1: 50; the temperature of the cross-linking treatment is 25 ℃, and the time is 2 hours;
(7) rinsing the composite membrane obtained in the step (6) by using deionized water to obtain the antiviral medical nano fiber mask material.
According to the pocket-insertion type mask, when the middle layer antiviral medical nano-fiber mask material is subjected to aerosol particle filtration test, when the average diameter of NaCl aerosol particles for test is 260nm and the flow rate is 85L/min, the filtration efficiency and the air resistance are 84.28% and 105.4Pa respectively; using ISO 18184: 2014(E) detection method, antiviral (influenza A virus, H1N1) performance test is carried out on the antiviral medical nano-fiber mask material, and when a host is MDCK cells, the antiviral survival rate is 61.3%.
Comparative example 1
A pocket-insert mask, which is substantially the same as that of example 1, except that no organosilicon quaternary ammonium salt of an antiviral agent is added in the step (2); the prepared composite membrane is shown in figure 1, (a) is a surface SEM topography of the prepared composite membrane; (b) is a real object picture.
Finally, when the medical nano-fiber mask material of the middle layer of the pocket-insertion type mask is subjected to aerosol particle filtration test, when the average diameter of NaCl aerosol particles for test is 260nm and the flow rate is 85L/min, the filtration efficiency and the air resistance are respectively 89.32% and 110.3 Pa; using ISO 18184: 2014(E) detection method, the medical nano-fiber mask material is subjected to antiviral (influenza A virus, H1N1) performance test, and when the host is MDCK cells, the antiviral survival rate is 3.32%.
Comparing comparative example 1 with example 1, in the aerosol particle filtration test, the filtration effect of the two has no obvious difference from the test result of air resistance, and in the test of antiviral performance, the antiviral survival rate of the medical nano-fiber mask material prepared in comparative example 1 is far lower than that of the antiviral medical nano-fiber mask material prepared in example 1, because no organosilicon quaternary ammonium salt of antiviral drug is added in comparative example 1, the virus and bacteria proliferated on the mask can not be inhibited in the use process, and the virus diffusion can not be effectively avoided.
Example 2
A pocket-plug type mask has a three-layer composite structure, including an inner layer, a middle layer and an outer layer;
the inner layer and the outer layer are polypropylene non-woven fabrics which are connected to form a pocket, and the average diameter of the fiber is 50 μm;
the middle layer is an inserting piece which can be pulled out from the inserting pocket; the middle layer is made of an antiviral medical nano-fiber mask material, the average diameter of the fiber is 230nm, and the preparation method comprises the following steps: preparing an electrostatic spinning solution containing both a polymer material and an antiviral drug into a nanofiber membrane, and then performing cross-linking treatment on the nanofiber membrane to obtain an antiviral medical nanofiber mask material;
the preparation method of the antiviral medical nano-fiber mask material comprises the following specific steps:
(1) a polymer polyvinyl alcohol (PVA) (Mw 146000, alcoholysis degree 99%) was dissolved in water, and stirred at 95 ℃ for 12 hours to prepare a first homogeneous solution with a concentration of 11.11 wt%;
(2) dissolving a drop of nonionic surfactant Triton X-100 and an antiviral drug organosilicon quaternary ammonium salt in the first uniform solution obtained in the step (1), and stirring for 1h at room temperature to obtain an electrostatic spinning solution; wherein the concentration of organosilicon quaternary ammonium salt as antiviral drug is 27.78 wt%
(3) Carrying out electrostatic spinning on the electrostatic spinning solution obtained in the step (2) to obtain nanofiber non-woven fabric, and carrying out cold pressing treatment to obtain a nanofiber membrane;
wherein the technological parameters of electrostatic spinning are as follows: the voltage is 15kV, the orifice diameter is 0.7mm, the solution flow rate is 12 mu L/min, the temperature of the spinning environment is 25 ℃, the relative humidity of the spinning environment is 40%, the receiving distance is 15cm, and the rotating speed of the receiving roller is 600 r/min; the pressure of the cold pressing treatment is 4MPa, and the time is 20 s; the thickness of the nanofiber membrane is 20 μm, and the porosity is 70%;
(4) mixing hydrochloric acid in acetone to prepare a second uniform solution with the concentration of 0.23 wt%;
(5) mixing a cross-linking agent glutaraldehyde in the second uniform solution obtained in the step (4), and stirring at room temperature for 10min to obtain a cross-linking agent solution with the concentration of 1.9 wt%;
(6) immersing the nanofiber membrane obtained in the step (3) into the cross-linking agent solution obtained in the step (5) for cross-linking treatment to obtain a composite membrane, wherein (a) is a surface SEM topography of the prepared composite membrane as shown in FIG. 2; (b) is a real object picture; wherein the mass ratio of the nanofiber membrane to the cross-linking agent solution is 1: 200; the temperature of the cross-linking treatment is 25 ℃, and the time is 2 hours;
(7) rinsing the composite membrane obtained in the step (6) by using deionized water to obtain the antiviral medical nano fiber mask material.
According to the pocket-insertion type mask, when the middle layer antiviral medical nano-fiber mask material is subjected to aerosol particle filtration test, when the average diameter of NaCl aerosol particles for test is 260nm and the flow rate is 85L/min, the filtration efficiency and the air resistance are 80.64% and 101.9Pa respectively; using ISO 18184: 2014(E) detection method, antiviral (influenza A virus, H1N1) performance test is carried out on the antiviral medical nano-fiber mask material, and when a host is MDCK cells, the antiviral survival rate is 91.63%.
Example 3
A pocket-plug type mask has a three-layer composite structure, including an inner layer, a middle layer and an outer layer;
the inner layer and the outer layer are polypropylene non-woven fabrics which are connected to form a pocket, and the average diameter of the fiber is 50 μm;
the middle layer is an inserting piece which can be pulled out from the inserting pocket; the middle layer is made of an antiviral medical nano-fiber mask material, the average diameter of the fiber is 230nm, and the preparation method comprises the following steps: preparing an electrostatic spinning solution containing both a polymer material and an antiviral drug into a nanofiber membrane, and then performing cross-linking treatment on the nanofiber membrane to obtain an antiviral medical nanofiber mask material;
the preparation method of the antiviral medical nano-fiber mask material comprises the following specific steps:
(1) dissolving a polymer polyvinyl alcohol (PVA) (Mw 146000, alcoholysis degree 99%) in water, and stirring at 95 ℃ for 12 hours to prepare a first uniform solution with a concentration of 12.9 wt%;
(2) dissolving a drop of nonionic surfactant Triton X-100 and an antiviral drug organosilicon quaternary ammonium salt in the first uniform solution obtained in the step (1), and stirring for 1h at room temperature to obtain an electrostatic spinning solution; wherein the concentration of the organosilicon quaternary ammonium salt used as the antiviral drug is 48.4 wt%;
(3) carrying out electrostatic spinning on the electrostatic spinning solution obtained in the step (2) to obtain nanofiber non-woven fabric, and carrying out cold pressing treatment to obtain a nanofiber membrane;
wherein the technological parameters of electrostatic spinning are as follows: the voltage is 15kV, the orifice diameter is 0.7mm, the solution flow rate is 12 mu L/min, the temperature of the spinning environment is 25 ℃, the relative humidity of the spinning environment is 40%, the receiving distance is 15cm, and the rotating speed of the receiving roller is 600 r/min; the pressure of the cold pressing treatment is 4MPa, and the time is 20 s; the thickness of the nanofiber membrane is 230 μm, and the porosity is 70%;
(4) mixing hydrochloric acid in acetone to prepare a second uniform solution with the concentration of 0.23 wt%;
(5) mixing a cross-linking agent glutaraldehyde in the second uniform solution obtained in the step (4), and stirring at room temperature for 10min to obtain a cross-linking agent solution with the concentration of 1.9 wt%;
(6) soaking the nanofiber membrane obtained in the step (3) into the cross-linking agent solution obtained in the step (5) for cross-linking treatment to obtain a composite membrane; wherein the mass ratio of the nanofiber membrane to the cross-linking agent solution is 1: 150; the temperature of the cross-linking treatment is 25 ℃, and the time is 2 hours;
(7) rinsing the composite membrane obtained in the step (6) by using deionized water to obtain the antiviral medical nano fiber mask material.
According to the pocket-insertion type mask, when the middle layer antiviral medical nano-fiber mask material is subjected to aerosol particle filtration test, when the average diameter of NaCl aerosol particles for test is 260nm and the flow rate is 85L/min, the filtration efficiency and the air resistance are 75.41% and 96.4Pa respectively; using ISO 18184: 2014(E) detection method, antiviral (influenza A virus, H1N1) performance test is carried out on the antiviral medical nano-fiber mask material, and when a host is MDCK cells, the antiviral survival rate is 93.21%.
Claims (10)
1. A pocket-insertion type mask is characterized by having a three-layer composite structure, wherein an inner layer and an outer layer are connected to form a pocket, and a middle layer is an insertion piece which can be pulled out of the pocket; the middle layer is made of an antiviral medical nano-fiber mask material, the average diameter of the fiber is 100-500 nm, and the preparation method comprises the following steps: preparing the electrostatic spinning solution containing the polymer material and the antiviral drug into a nanofiber membrane, and performing cross-linking treatment on the nanofiber membrane to obtain the antiviral medical nanofiber mask material.
2. The pocket-insert mask according to claim 1, wherein the polymer material is X or a modified polymer of X, and X is polyvinyl alcohol, cellulose acetate, polyvinylidene fluoride, polysulfone, polystyrene, polyvinyl chloride, polycaprolactone, polylactic acid, sodium alginate, gelatin, polyacrylonitrile or polyethersulfone.
3. The pocket-insert mask as claimed in claim 1, wherein the antiviral drug is one or more of quaternary ammonium salts of organosilicon, Reidesvir, Abidol, Darunavir, Shuanghuanglian oral liquid, chloroquine phosphate, artemisinin, lamivudine, famciclovir and nevirapine.
4. The pocket-insert mask according to any one of claims 1 to 3, wherein the antiviral medical nanofiber mask material is prepared by the steps of:
(1) dissolving a polymer material in a solvent I to prepare a first uniform solution;
(2) dissolving an antiviral drug in the first uniform solution obtained in the step (1) to obtain an electrostatic spinning solution;
(3) carrying out electrostatic spinning on the electrostatic spinning solution obtained in the step (2) to obtain nanofiber non-woven fabric, and carrying out cold pressing treatment to obtain a nanofiber membrane;
(4) mixing hydrochloric acid in a solvent II to prepare a second uniform solution;
(5) mixing a cross-linking agent in the second uniform solution obtained in the step (4) to obtain a cross-linking agent solution;
(6) soaking the nanofiber membrane obtained in the step (3) into the cross-linking agent solution obtained in the step (5) for cross-linking treatment to obtain a composite membrane;
(7) rinsing the composite membrane obtained in the step (6) by using deionized water to obtain the antiviral medical nano fiber mask material.
5. The pocket-insert type mask according to claim 4, wherein in the step (1), the solvent I is one or more selected from the group consisting of water, acetamide, N-dimethylethanol, N-dimethylformamide, isopropanol, N-butanol, acetone, 1, 4-dioxane, tetrahydrofuran, acetic acid, dichloromethane and chloroform; the concentration of the first homogeneous solution is 6-25 wt%; in the step (2), the concentration of the antiviral drug in the electrostatic spinning solution is 5-48.4 wt%.
6. The pocket-insert type mask according to claim 4, wherein in the step (3), the electrostatic spinning process parameters are as follows: the voltage is 5-25 kV, the aperture of a nozzle is 0.2-3 mm, the flow rate of a solution is 2-30 mu L/min, the temperature of a spinning environment is 15-50 ℃, the relative humidity of the spinning environment is 40-60%, the receiving distance is 10-20 cm, and the rotating speed of a receiving roller is 300-800 r/min; the pressure of cold pressing treatment is 2-8 MPa, and the time is 10-40 s; the thickness of the nanofiber membrane is 10-40 mu m, and the porosity is 45-80%.
7. The pocket-insert type mask according to claim 4, wherein in the step (4), the solvent II is one or more selected from the group consisting of water, acetamide, N-dimethylethanol, N-dimethylformamide, isopropanol, N-butanol, acetone, 1, 4-dioxane, tetrahydrofuran, acetic acid, dichloromethane and chloroform; the concentration of the second homogeneous solution is 0.2-1 wt%.
8. The pocket-insert mask of claim 4, wherein in step (5), the cross-linking agent is one or more of glutaraldehyde, glyoxal, acrylic acid, hydroxyethyl acrylate hydroxypropyl acrylate, methacrylic acid, divinylbenzene, N-methylol acrylamide, diacetone acrylamide, hydroxyethyl methacrylate, trimethylolpropane, polypropylene glycol glycidyl ether, aziridine, and acrylonitrile; the concentration of the cross-linking agent in the cross-linking agent solution is 1-5 wt%.
9. The pocket-insert mask according to claim 4, wherein in the step (6), the mass ratio of the nanofiber membrane to the cross-linking agent solution is 1-5: 50-200; the temperature of the cross-linking treatment is 15-35 ℃, and the time is 1-4 h.
10. The pocket-insert type mask as claimed in claim 1, wherein the inner layer and the outer layer are polypropylene non-woven fabrics, and the average diameter of the fiber is 10 to 50 μm.
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