CN112512659B

CN112512659B - Filtering and filtering device

Info

Publication number: CN112512659B
Application number: CN201980050185.8A
Authority: CN
Inventors: 横田秀辅; 近藤孝志; 万寿优; 西川美和子
Original assignee: Murata Manufacturing Co Ltd
Current assignee: Murata Manufacturing Co Ltd
Priority date: 2018-08-23
Filing date: 2019-08-07
Publication date: 2022-07-22
Anticipated expiration: 2039-08-07
Also published as: JPWO2020039936A1; CN112512659A; US11951422B2; WO2020039936A1; JP2022044839A; CN115069003A; US20210077925A1; JP7380722B2; JP7021704B2

Abstract

The invention provides a filter capable of being easily cut off by applying external force. The filter of the invention is a cylindrical filter provided with a 1 st opening and a 2 nd opening opposite to the 1 st opening, and comprises: a filter base portion defining a plurality of through holes arranged in a square lattice, the filter base portion including: a continuous portion formed continuously in a direction from the 1 st opening toward the 2 nd opening of the filter and in a circumferential direction along an outer periphery of the filter in a cross section when the filter is cut in a direction orthogonal to the direction from the 1 st opening toward the 2 nd opening of the filter; and a discontinuous section formed by partially shifting the continuous section in a direction from the 1 st opening to the 2 nd opening of the filter.

Description

Filtering and filtering device

Technical Field

The present invention relates to a filter.

Background

As a filter, for example, a filter having a cylindrical shape is known (for example, see patent document 1).

The filter of patent document 1 includes: a tubular wire mesh on the inner side, the longitudinal overlapping portion being welded; a filter main body in which a felt of metal fibers is wound around an inner cylindrical wire net with a predetermined thickness, and which is impregnated with a heat-resistant resin and dried; and an outer cylindrical wire mesh welded at the overlapping portion in the longitudinal direction.

Prior art documents

Patent document

Patent document 1: japanese patent laid-open publication No. 9-276636

Disclosure of Invention

Problems to be solved by the invention

In recent years, there has been a demand for a filter having a cylindrical shape that can be easily cut by applying an external force.

The invention aims to provide a filter which can be easily cut off by applying external force.

Means for solving the problems

A filter according to one aspect of the present invention is a cylindrical filter provided with a 1 st opening and a 2 nd opening opposed to the 1 st opening, wherein,

the disclosed device is provided with: a filter base body portion defining a plurality of through holes arranged in a square lattice,

the filter base portion includes:

a continuous portion formed continuously in a direction from the 1 st opening toward the 2 nd opening of the filter and in a circumferential direction along an outer periphery of the filter in a cross section when the filter is cut in a direction orthogonal to the direction from the 1 st opening toward the 2 nd opening of the filter; and

and a discontinuous section formed by partially shifting the continuous section in a direction orthogonal to the circumferential direction of the filter.

Effects of the invention

According to the present invention, it is possible to provide a filter which can be easily cut by applying an external force.

Drawings

Fig. 1 is a schematic perspective view of an example of a filter according to embodiment 1 of the present invention.

Fig. 2 is an enlarged schematic perspective view of a part of the discontinuous portion of the filter unit shown in fig. 1.

Fig. 3 is an enlarged schematic plan view of a part of the discontinuous portion of the filter unit shown in fig. 1.

Fig. 4 is a diagram showing an example of a method of cutting a filter according to embodiment 1 of the present invention.

Fig. 5A is a schematic view showing an example of the steps of the method for manufacturing a filter according to embodiment 1 of the present invention.

Fig. 5B is a schematic view showing an example of the steps of the method for manufacturing a filter according to embodiment 1 of the present invention.

Fig. 5C is a schematic view showing an example of the steps of the method for manufacturing a filter according to embodiment 1 of the present invention.

Fig. 5D is a schematic view showing an example of the steps of the method for manufacturing a filter according to embodiment 1 of the present invention.

Fig. 5E is a schematic view showing an example of the steps of the method for manufacturing a filter according to embodiment 1 of the present invention.

Fig. 6A is a schematic view showing an example of a method of forming the discontinuous portion.

Fig. 6B is a schematic diagram illustrating an example of a method of forming the discontinuous portion.

Fig. 7 is a schematic enlarged view showing an example of an analysis model used in the stress analysis simulation.

Fig. 8A is a diagram showing an example of a stress analysis simulation result of the analysis model of comparative example 1.

Fig. 8B is an enlarged view of a portion Z1 of comparative example 1 of fig. 8A.

Fig. 9A is a diagram showing an example of the result of the stress analysis simulation of the analysis model of example 1.

Fig. 9B is an enlarged view of a portion Z2 of embodiment 1 of fig. 9A.

Fig. 10 is a diagram showing a portion where stress analysis is performed in a discontinuous portion of the filter of the analysis model.

Fig. 11 is a diagram showing a detailed position where stress analysis is performed.

Fig. 12A is a diagram showing a schematic configuration of an analysis model of comparative example 2.

Fig. 12B is a diagram showing a schematic configuration of an analysis model in example 9.

Fig. 13 is a graph showing an example of the stress analysis results of comparative example 2 and examples 2 to 9.

FIG. 14 is a graph showing the relationship between the maximum principal stresses of examples 2 to 9 based on comparative example 2.

Fig. 15A is a diagram showing an example of a state of filtering by using the filter according to embodiment 1 of the present invention.

Fig. 15B is a diagram showing another example of filtering performed by using the filter according to embodiment 1 of the present invention.

Fig. 16 is a schematic perspective view of an example of a filter according to embodiment 2 of the present invention.

Fig. 17 is a graph showing an example of the stress analysis results of comparative example 3 and examples 10 to 14.

Fig. 18 is a graph showing an example of the stress analysis results of comparative example 4 and examples 15 to 17.

Detailed Description

(pass through for carrying out the invention)

In recent years, a cross flow (cross-f 1) has been used in a filter using a cylindrical filter_ow) filtering method, there is an increasing demand for observing the filtering object captured by the filter, after filtering the fluid containing the filtering object. For example, after filtering with a filter, there is a case where the filter that has captured the object to be filtered is installed in an optical microscope and the object to be filtered is subjected to filteringThe requirements for line observation.

However, in the filter cartridge, since the object to be filtered is captured inside the filter cartridge, it is difficult to observe the object to be filtered captured by the filter cartridge. Therefore, after filtering using the filter, the filter is cut by applying an external force to the filter, and the filter object captured inside the filter is observed.

Under such circumstances, it is required that a cylindrical filter is not broken by the force of the fluid during filtration and can be easily cut off by applying a force from the outside after the filtration is completed.

Accordingly, the present inventors have completed the following invention in order to provide a cylindrical filter which can be easily cut by applying a force from the outside while maintaining the strength capable of withstanding filtration.

the filter base portion includes:

With this configuration, the filter can be easily cut by applying a force from the outside to the cylindrical filter.

The filter base portion may include: a 1 st filter base portion extending in the discontinuous portion in a direction from the 1 st opening toward the 2 nd opening of the filter; a plurality of 2 nd filter base body portions connected to one side of the 1 st filter base body portion in the circumferential direction of the filter; and a plurality of No. 3 filter base body portions connected to the other side of the No. 1 filter base body portion in the circumferential direction of the filter,

the plurality of 1 st connection parts connecting the plurality of 2 nd filter base body parts and the 1 st filter base body part and the plurality of 2 nd connection parts connecting the plurality of 3 rd filter base body parts and the 1 st filter base body part are shifted in a direction from the 1 st opening toward the 2 nd opening of the filter.

With this configuration, in the 1 st filter base portion forming the discontinuous portion, the plurality of 2 nd filter base portions and the plurality of 3 rd filter base portions are respectively formed with the connection points, and the plurality of 2 nd filter base portions and the plurality of 3 rd filter base portions extend in the circumferential direction of the filter. This makes it easy to generate stress in the discontinuous portion, and the filter can be cut more easily.

The plurality of 1 st connecting parts may be respectively disposed between the plurality of 2 nd connecting parts adjacent to each other.

With this configuration, the filter can be cut more easily by applying a force from the outside to the cylindrical filter.

The width of the 1 st filter base body portion may be equal to the width of the filter base body portion forming the continuous portion.

The filter may be a membrane-like filter having one end and the other end, and formed into a cylindrical shape by joining the one end and the other end,

the discontinuous portion is formed at a joint portion joining the one end and the other end.

With this configuration, the discontinuous portion can be easily formed, and the cylindrical filter can be cut more easily by applying a force from the outside.

The filter base portion may contain at least one of a metal and a metal oxide as a main component.

With such a configuration, the cylindrical filter can be easily cut by applying a force from the outside while improving the mechanical strength.

Embodiment 1 according to the present invention will be described below with reference to the drawings. In the drawings, elements are exaggerated for ease of explanation.

(embodiment mode 1)

[ integral Structure ]

Fig. 1 is a schematic perspective view of an example of a filter 1A according to embodiment 1 of the present invention. Fig. 2 is an enlarged schematic perspective view of a part of the discontinuous section 14 of the filter unit 10 of fig. 1. Fig. 3 is an enlarged schematic plan view of a part of the discontinuous portion 14 of the filter unit 10 of fig. 1. The directions D1 and D2 in fig. 1 show the circumferential direction of the filter remover 1A and the direction orthogonal to the circumferential direction of the filter remover 1A, respectively. The direction X, Y, Z in fig. 2 and 3 shows the lateral direction, the longitudinal direction, and the thickness direction of the filter remover 1A, respectively.

As shown in fig. 1, the filter 1A is formed in a cylindrical shape provided with a 1 st opening 2 and a 2 nd opening 3 opposed to the 1 st opening 2. The 1 st opening 2 and the 2 nd opening 3 are opposed to each other in the longitudinal direction (Y direction) of the filter 1A. In the present specification, the circumferential direction D1 means a direction that is orthogonal to the direction D2 from the 1 st opening 2 to the 2 nd opening 3 of the filter 1A and that runs along the shape of the outer peripheral portion of the filter 1A. Specifically, the circumferential direction D1 means a direction along the outer periphery of the filter 1A in a cross section when the filter 1A is cut in a direction orthogonal to the direction D2 from the 1 st opening 2 toward the 2 nd opening 3 of the filter 1A. In embodiment 1, the circumferential direction D1 means the circumferential direction of the filter remover 1A.

In embodiment 1, the filter 1A includes a filter section 10 and a frame section 20. The filter portion 10 is formed in a hollow cylindrical shape. The frame portion 20 is disposed at both ends of the filter portion 10 and formed in a ring shape.

In embodiment 1, an example in which the filter 1A includes the frame portion 20 is described, but the frame portion 20 is not necessarily required. In embodiment 1, a cylindrical filter 1A will be described as an example, but the shape of the filter 1A is not limited to the cylindrical shape. The filter 1A may have a cylindrical shape.

In embodiment 1, the filter remover 1A is formed into a cylindrical shape by rolling up a filter having a rectangular film shape having the 1 st main surface PS1 and the 2 nd main surface PS2 opposed to the 1 st main surface PS 1. The 1 st main surface PS1 is located on the outer surface of the cylindrical filter 1A, and the 2 nd main surface PS2 is located on the inner surface of the cylindrical filter 1A.

The filter 1A is a filter for cross-flow filtration. In the filter 1A, a fluid containing a filter object flows inside the cylindrical shape. Thereby, the filter object is captured by the 2 nd main surface PS2 of the filter 1A, and a part of the fluid flows from the 2 nd main surface PS2 of the filter 1A toward the 1 st main surface PS 1.

In the present specification, the term "object to be filtered" means an object to be filtered among objects contained in a fluid. For example, the object to be filtered may be powder or fine particles. The object to be filtered may be a substance derived from a living organism contained in the fluid. The term "biologically derived substance" means a substance derived from a living body such as a cell (eukaryote), a bacterium (eubacterium), or a virus. Examples of the cells (eukaryotes) include artificial pluripotent stem cells (iPS cells), ES cells, stem cells, mesenchymal stem cells, monocytes, single cells, cell aggregates, planktonic cells, adherent cells, nerve cells, leukocytes, regenerative medicine cells, autologous cells, cancer cells, circulating blood cancer cells (CTCs), HL-60, HELA, and fungi. Examples of the bacteria (eubacteria) include Escherichia coli and Mycobacterium tuberculosis.

As shown in fig. 1 to 3, the filter unit 10 is formed of a filter base 12 defining a plurality of through holes 11 arranged periodically. In embodiment 1, the plurality of through holes 11 are arranged in a square lattice arrangement. The filter base portion 12 forming the filter portion 10 contains at least one of a metal and a metal oxide as a main component. The filter base portion 12 may be, for example, gold, silver, copper, platinum, nickel, palladium, titanium, alloys thereof, and oxides thereof.

The filter base portions 12 have continuous portions 13 and discontinuous portions 14, the continuous portions 13 are formed continuously in a grid pattern, and the discontinuous portions 14 are formed by shifting the continuous portions 13 in a direction D2 perpendicular to the circumferential direction D1 of the filter 1A.

As shown in fig. 2 and 3, the continuous portion 13 is formed continuously in a lattice shape. The term "continuously formed in a lattice shape" means that the part of the filter base body portion 12 extending in the circumferential direction D1(X direction) of the filter 1A is formed so as not to have an inflection point, and the part of the filter base body portion 12 extending in the longitudinal direction (Y direction) of the filter 1A is formed so as not to have an inflection point. In embodiment 1, the filter base body portion 12 is integrally formed.

In other words, "formed continuously in a lattice shape" means that the filter element 1A is formed continuously in the direction D2 from the 1 st opening 2 to the 2 nd opening 3 of the filter element 1A and continuously in the circumferential direction D1, and the circumferential direction D1 is a direction along the outer periphery of the filter element 1A in a cross section when the filter element 1A is cut in a direction orthogonal to the direction D2 from the 1 st opening 2 to the 2 nd opening 3 of the filter element 1A.

In the continuous portion 13, a plurality of through holes 11 are periodically arranged so that the Hamiltonian (Hamiltonian) has translational symmetry. For example, the continuous portion 13 means that a portion of the filter base body portion 12 extending in the circumferential direction D1 of the filter 1A or a portion extending in the direction D2 perpendicular to the circumferential direction D1 has periodicity locally. In embodiment 1, the direction D2 perpendicular to the circumferential direction D1 means a direction from the 1 st aperture 2 to the 2 nd aperture 3.

In this manner, in the filter base portion 12, the continuous portions 13 are formed continuously in a lattice shape. Therefore, the plurality of through holes 11 defined by the filter base portion 12 are periodically arranged on the 1 st main surface PS1 and the 2 nd main surface PS2 of the filter portion 10. Specifically, the plurality of through holes 11 are arranged in a matrix at equal intervals in the filter unit 10.

In embodiment 1, the through-holes 11 have a square shape when viewed from the 1 st main surface PS1 side of the filter part 10, that is, when viewed from the Z direction. The plurality of through holes 11 are provided at equal intervals in two arrangement directions parallel to the sides of the square, i.e., in the X direction and the Y direction in fig. 2 and 3, when viewed from the 1 st main surface PS1 side (Z direction) of the filter portion 10. By providing the plurality of through holes 11 in a square lattice arrangement in this manner, the aperture ratio can be increased, and the passage resistance of the fluid to the filter 1A can be reduced.

The intervals between the plurality of through holes 11 can be appropriately designed according to the type (size, form, property, elasticity) or amount of the object to be filtered. Here, the interval of the through holes 11 means, as shown in fig. 3, an interval b between the center of an arbitrary through hole 11 and the center of an adjacent through hole 11 when the through hole 11 is viewed from the 1 st main surface PS1 side of the filter portion 10. In the case of the periodically arranged structure, the interval b of the through holes 11 is, for example, 1 to 10 times larger than the side d of the through holes 11, and preferably 3 times smaller than the side d of the through holes 11. Alternatively, for example, the filter portion 10 has an opening ratio of 10% or more, and preferably, an opening ratio of 25% or more. With this configuration, the passage resistance of the fluid with respect to the filter unit 10 can be reduced. The aperture ratio can be calculated by (the area occupied by the through holes 11)/(the projected area of the 1 st main surface PS1 assuming that no holes are formed in the through holes 11).

The thickness of the filter portion 10 is preferably 0.1 times or more and 10 times or less the size (side d) of the through hole 11. More preferably, the thickness of the filter portion 10 is 0.5 times or more and 10 times or less larger than the size (side d) of the through hole 11. With this configuration, the resistance of the filter 1A to the fluid can be reduced. As a result, the pressure on the object to be filtered can be reduced.

In the filter unit 10, the 2 nd main surface PS2 that is in contact with the fluid containing the object to be filtered preferably has a small surface roughness. Here, the surface roughness means an average value of differences between the maximum value and the minimum value measured by a stylus type level difference meter at any five positions on the 2 nd main surface PS 2. In embodiment 1, the surface roughness is preferably smaller than the size of the object to be filtered, and more preferably smaller than half the size of the object to be filtered. In other words, the openings of the plurality of through holes 11 on the 2 nd main surface PS2 of the filter part 10 are formed on the same plane (XY plane). The filter base portions 12, which are portions of the filter portion 10 where the through holes 11 are not formed, are integrally connected to each other. With this structure, adhesion of the filter object to the 2 nd main surface PS2 of the filter unit 10 can be reduced, and the resistance of the fluid can be reduced.

In the through-hole 11, the opening on the 1 st main surface PS1 side and the opening on the 2 nd main surface PS2 side communicate with each other through a continuous wall surface. Specifically, the through-hole 11 is provided so that the opening on the 1 st main surface PS1 side can be projected to the opening on the 2 nd main surface PS2 side. That is, when the filter unit 10 is viewed from the 1 st main surface PS1 side, the through-holes 11 are provided so that the opening on the 1 st main surface PS1 side overlaps with the opening on the 2 nd main surface PS2 side.

The shape (cross-sectional shape) of the through-hole 11 projected on the plane perpendicular to the 1 st main surface PS1 of the filter portion 10 is rectangular. Specifically, the cross-sectional shape of the through hole 11 is a rectangle in which the length of one side of the filter remover 1A in the circumferential direction D1 is longer than the length of one side of the filter remover 1A in the thickness direction. The cross-sectional shape of the through-hole 11 is not limited to a rectangle, and may be a tapered shape such as a parallelogram or a trapezoid, a symmetrical shape, or an asymmetrical shape.

The discontinuous portion 14 is formed by shifting a part of the continuous portion 13 in a direction D2 perpendicular to the circumferential direction D1 of the filter 1A. Specifically, the continuous portion 13 is formed by shifting a portion extending in the lateral direction (X direction) of the filter remover 1A in the longitudinal direction (Y direction) of the filter remover 1A.

The discontinuous portion 14 means a portion of the filter base body portion 12 extending in the circumferential direction D1 of the filter 1A or a portion extending in the direction D2 perpendicular to the circumferential direction D1, which has inflection points where three branches are formed.

As shown in fig. 2 and 3, the filter base segments 12 include the 1 st filter base segment 12a of the discontinuous section 14, which extends in the direction D2(Y direction) perpendicular to the circumferential direction D1(X direction) of the filter 1A. The filter base body 12 includes a plurality of 2 nd filter base body portions 12b and a plurality of 3 rd filter base body portions 12c, the plurality of 2 nd filter base body portions 12b are connected to one side of the 1 st filter base body portion 12a in the circumferential direction D1(X direction) of the filter 1A, and the plurality of 3 rd filter base body portions 12c are connected to the other side of the 1 st filter base body portion 12a in the circumferential direction D1(X direction) of the filter 1A. The plurality of 2 nd filter base body portions 12b and the plurality of 3 rd filter base body portions 12c are integrally formed.

In the discontinuous portion 14, a plurality of 1 st connection portions 15 connecting the plurality of 2 nd

filter base portions

12b and 1 st filter base portions 12a and a plurality of 2 nd connection portions 16 connecting the plurality of 3 rd

filter base portions

12c and 1 st filter base portions 12a are formed.

The plurality of 1 st connection portions 15 and the plurality of 2 nd connection portions 16 are separated from each other in the 1 st filter base body portion 12 a. Specifically, the 1 st connection portion 15 is arranged between two adjacent 2 nd connection portions 16. In other words, each of the 1 st connection portions 15 is disposed between the adjacent 2 nd connection portions 16.

Therefore, in the discontinuous portion 14, the arrangement of the plurality of 1 st through holes 11A and the plurality of 2 nd through holes 11b adjacent to the plurality of 1 st through holes 11A is shifted in the direction D2(Y direction) orthogonal to the circumferential direction D1 of the filter 1A. Further, the plurality of 1 st through holes 11A and the plurality of 2 nd through holes 11b are arranged in the height direction (Y direction) of the filter remover 1A, that is, in the direction D2 orthogonal to the circumferential direction D1 of the filter remover 1A in the discontinuous portion 14.

In this manner, the filter 1A is configured such that the discontinuous portion 14 is formed by shifting a part of the continuous portion 13 in the direction D2(Y direction) orthogonal to the circumferential direction D1(X direction) of the filter 1A. In the discontinuous portion 14, the number of connection portions to connect the filter base portion 12 can be increased as compared with the continuous portion 13. The connection portion in the continuous portion 13 means a portion where the filter base body portion 12 extending in the lateral direction (X direction) of the filter 1A and the filter base body portion 12 extending in the longitudinal direction (Y direction) of the filter 1A are connected to intersect. The connection portions in the discontinuous portion 14 mean the 1 st connection portion 15 and the 2 nd connection portion 16.

In the discontinuous portion 14, the connecting portion is formed more than the continuous portion 13, and therefore stress is more likely to concentrate than in the continuous portion 13. Therefore, the discontinuous portion 14 is more likely to be broken or deformed when a force is applied from the outside than the continuous portion 13. That is, the discontinuous portion 14 can be cut more easily than the continuous portion 13. In addition, the discontinuous portion 14 has a strength that is not damaged by a force of fluid flowing therethrough at the time of filtration. In this manner, the filter 1A can be easily cut by applying a force from the outside while maintaining the strength capable of withstanding filtration. As a result, in the filter 1A, after the end of filtration, the discontinuity 14 is cut by applying a force from the outside, and the filtering object captured by the filter 1A can be easily observed.

In embodiment 1, the width of the 1 st filter base portion 12a forming the discontinuous portion 14 is equal to the width of the filter base portion 12 forming the continuous portion 13. Specifically, in the discontinuous section 14, the width of the 1 st filter base body portion 12a extending in the direction D2(Y direction) orthogonal to the circumferential direction D1(X direction) of the cylindrical filter 1A is equal to the width of the filter base body portions 12 forming the continuous section 13. Here, "equal" includes an error in the range of 10%.

The frame 20 is a member disposed at each end of the cylindrical filter portion 10. The frame 20 is formed in an annular shape as viewed from one end side or the other end side of the cylindrical filter unit 10.

Information on the filter (for example, the size of the through hole 11) may be displayed on the frame 20. Thus, the hole size of the through hole 11 can be grasped without measuring the length again.

In embodiment 1, the material constituting the frame portion 20 is the same as the material constituting the filter portion 10 (filter base portion 12).

In embodiment 1, the cylindrical filter 1A has a diameter of 12mm, a height of 22mm, and a film thickness of 2 μm. One side of the square through-hole 11 was 6 μm. The width of the filter base body 12 was 2.5 μm. The filter 1A is not limited to these dimensions, and may be manufactured in other dimensions.

[ actions ]

A method of cutting the filter 1A will be described with reference to fig. 4. Fig. 4 shows an example of a method of cutting the filter 1A according to embodiment 1 of the present invention.

As shown in fig. 4, the cylindrical filter 1A can be easily cut by cutting the discontinuous portion 14 along a cutting line CL1 extending in the height direction (Y direction) of the filter 1A.

Cutting is performed, for example, using forceps and a scalpel.

[ production method ]

Next, an example of a method for manufacturing the filter 1A will be described with reference to fig. 5A to 5E. Fig. 5A to 5E are schematic diagrams illustrating an example of the steps of the method for manufacturing the filter 1A according to embodiment 1 of the present invention. Fig. 5A to 5E show steps before the filter 1A is processed into a cylindrical shape.

As shown in fig. 5A, a copper thin film 32 having a thickness of 1.5 μm is formed on a substrate 31 of silicon or the like. The copper thin film 32 can be formed by evaporation or sputtering. At this time, an intermediate layer 33 of Ti having a thickness of 0.5 μm was formed in order to improve the adhesion between the substrate 31 and the copper thin film 32.

Next, a resist was applied on the copper thin film 32 by spin coating and dried, thereby forming a resist film having a thickness of 2 μm.

As shown in fig. 5B, the resist film 34 is subjected to exposure and development processing, and the resist film 34 at a portion corresponding to the filter base portion 12 is removed. In addition, the hole shape is square.

As shown in fig. 5C, the filter base body portion 12 including the Ni plating film 35 is formed at the portion from which the resist film 34 is removed by electroforming. Next, the resist film 34 is removed using an organic solvent, thereby producing the filter 1A before processing into a cylindrical shape.

In the case of the filter 1A alone, deformation by the fluid may occur when it is processed into a cylindrical shape, and therefore, it is necessary to improve the mechanical strength of the filter. Therefore, the reinforcement layer 36 is formed on the outer peripheral portion and the central line portion of the filter 1A. The reinforcing layer 36 had a thickness of 20 μm, and square through-holes 11 having a side of 290 μm were arranged in a square lattice at 10 μm intervals in the portion disposed in the filter base portion 12.

The reinforcing layer 36 was formed with a resist film 34 having a thickness of 30 μm by the same method as in fig. 5A to 5C, and the resist film 34 on the outer peripheral portion and the central line portion of the filter 1A was removed by exposure and development. As shown in fig. 5D, a reinforcing layer 36 including a Ni plating film is formed at the portion from which the resist film 34 is removed by electroforming. By removing the resist film 34 with an organic solvent, as shown in fig. 5E, a filter 1A having one side of the through-hole 11 of 6 μm and an aperture ratio of 50% was produced. At this stage, the filter 1A is a membrane-like filter having a rectangular shape. Frame 20 and support portion 21 of filter 1A are formed of reinforcing layer 36.

Although the example of forming the reinforcing layer 36 in the method of manufacturing the filter remover 1A of embodiment 1 is described, the reinforcing layer 36 is not necessarily required.

Next, an example of a method of processing the filter 1A into a cylindrical shape will be described with reference to fig. 6A and 6B. Fig. 6A and 6B are schematic diagrams illustrating an example of a method of forming the discontinuous portion 14.

As shown in fig. 6A, the filter 1A is wound around the outer periphery of a cylindrical container 40 made of polyacetal resin. The container 40 is a bottomed container. The side wall of the container 40 wound with the filter remover 1A is opened. The container 40 is an example of a container for filtration. The container 40 is not limited thereto.

Specifically, after an adhesive tape is adhered to the outer peripheral portion of the film-like filter remover 1A having one end E1 and the other end E2, the filter remover 1A is wound into a cylindrical shape and fixed by winding it around the case 40. More specifically, on the outer periphery of filter 1A, a double-sided tape (LINTEC; TackLiner TL-450S-16) having a thickness of 50 μm, which is a substrate of a polyester film and is thinly coated with an acrylic adhesive material, was adhered so as to match the widths of the outer periphery in the X and Y directions. Further, the other end E2 side of the outer peripheral portion formed a gap of 3mm in the longitudinal direction (X direction) to which the double-sided tape was not attached. The filter remover 1A to which the double-sided tape is adhered is wound into a cylindrical shape by winding it around the container 40 and fixed.

As shown in fig. 6B, one end E1 and the other end E2 of filter strainer 1A were joined by epoxy resin using an optical microscope and a micromanipulator (micromanipulator). Specifically, the joint surfaces of the one end E1 and the other end E2 and the gap between the outer peripheral portion of filter 1A and container 40 are bonded by applying epoxy resin. At this time, the one end E1 and the other end E2 are joined to each other with a shift so that the arrangement of the plurality of through holes 11 is discontinuous. Thereby, the discontinuous portion 14 is formed at the joint portion joining the one end E1 and the other end E2. More specifically, the other end E2 side of the outer peripheral portion to which the double-sided tape was not attached was moved using a micromanipulator while observing the outer peripheral portion with a microscope at a magnification of 1000 times, and the lattice at the joint portion was aligned. After the alignment, the joint surfaces of the one end E1 and the other end E2 and the gap between the outer periphery of the filter 1A and the container 40 are temporarily fixed with an adhesive tape, and epoxy resin is applied to the joint surfaces to perform the joint.

[ method of observing object to be filtered ]

After the filtration of the object to be filtered using the cylindrical filter 1A is completed, the discontinuous portion 14 of the filter 1A is cut off using forceps and a scalpel. Specifically, the epoxy resin joining one end E1 and the other end E2 of filter 1A was cut and peeled off, and discontinuous portion 14 was slowly peeled off from container 40 from the outer periphery using tweezers. Thus, the cylindrical filter 1A is cut at the discontinuous portion 14, and the object to be filtered captured by the 2 nd main surface PS2 of the filter 1A can be directly observed with a microscope. In particular, when the object to be filtered is a cell, the object to be filtered can be observed without damaging the cell.

[ simulation of stress analysis ]

The stress generated in the discontinuous portion 14 of the filter unit 10 will be described as a result of a stress analysis simulation using a femt manufactured by mitani corporation.

Fig. 7 is a schematic enlarged view showing an example of an analysis model used in the stress analysis simulation. As shown in fig. 7, the filter used in the analysis model is arranged in a square lattice with a plurality of square through holes 11. The through-hole 11 of the filter of the analysis model had a side L1 of 12 μm and a depth L2 of 5 μm. The width L3 of the filter base body 12 was 5 μm. Further, the filter of the analysis model was made of Ni.

In the stress analysis simulation, the deviations S1, S2 of the arrangement of the 1 st through hole 11a and the 2 nd through hole 11b formed at the discontinuous portion 14 were varied. The deviation S1 means a distance from a point CP1 where an extension line L12 extending the lower edge L11 of the 2 nd through hole 11b at the discontinuity 14 in the lateral direction (X direction) of the filter intersects with the side L21 of the 1 st through hole 11a to the lower edge L22 of the 1 st through hole 11 a. The offset S2 means the distance from the point CP1 at which the extension line L12 and the side L21 of the 1 st through-hole 11a intersect to the upper side L23 of the 1 st through-hole 11 a. The offset S2 can be calculated by "S2 ═ (12-S1)".

In the stress analysis simulation, the offsets S1 and S2 were adjusted, and stress analysis was performed in comparative example 1 having no offset and example 1 having an offset. In comparative example 1, S1 and S2 were 0 μm and 12.5 μm, respectively, and in example 1, S1 and S2 were 8.5 μm and 3.5 μm, respectively.

In the stress analysis simulation of comparative example 1 and example 1, 0.05N/m was applied to the main surface (the 1 st main surface PS1) of the discontinuous portion 14 in the filter circumferential direction D1 of the filter, that is, in the filter in which the analysis model was pulled in both the + X direction and the-X direction²Surface load (surface load).

Fig. 8A shows an example of the results of the stress analysis simulation of the analysis model of comparative example 1. Fig. 8B is an enlarged view of a portion Z1 of comparative example 1 of fig. 8A. Fig. 9A shows an example of the results of stress analysis simulation of the analysis model of example 1. Fig. 9B is an enlarged view of a portion Z2 of embodiment 1 of fig. 9A. As shown in fig. 8A and 8B and fig. 9A and 9B, stress is generated in a wider range in the discontinuous portion 14 of example 1 than in comparative example 1. This is because the number of connected parts of the filter base body 12 is larger in the discontinuous part 14 of example 1 than in comparative example 1. It is considered that stress is likely to occur at the connecting portion of the filter base 12, and therefore, in example 1, the number of locations where stress occurs is larger than in comparative example 1.

Next, analysis of the stress applied in the longitudinal direction (Y direction) of the filter at the discontinuous portion 14 was performed using the filter of the analysis model.

Fig. 10 shows a portion where stress analysis was performed at the discontinuous portion 14 of the filter of the analysis model. Fig. 11 shows a detailed position where stress analysis was performed. As shown in fig. 10 and 11, stress analysis was performed on the discontinuous portion 14 along an analysis line CL2 passing through one side of the 1 st through hole 11a facing the 2 nd through hole 11 b. Since the filter of the analysis model has a plurality of through holes 11 periodically formed, the stress distribution is considered to have periodicity. Therefore, it is considered that the interval between two through holes 11aa and 11ab adjacent to each other in the longitudinal direction (Y direction) of the filter is one cycle. In the stress analysis simulation, as shown in fig. 11, five analysis positions P1 to P5 were provided between the two through holes 11aa and 11ab on the analysis line CL2, and the stresses at the respective analysis positions were analyzed. The through hole 11aa is disposed below the through hole 11 ab.

As shown in fig. 11, the analysis position P1 is located at the center of one side of the through hole 11aa passing through the analysis line CL 2. The analysis position P2 is located above the analysis position P1 and at the corner of the through hole 11 aa. The analysis position P3 is located in the filter base portion 12a between the through hole 11aa and the through hole 11ab adjacent to the through hole 11aa, and is located at a distance equal to each other from the corner of the through hole 11aa and the corner of the through hole 11 ab. The analysis position P4 is located above the analysis position P3 and at the corner of the through-hole 11ab arranged on the side of the through-hole 11 aa. The analysis position P5 is located at the center of one side of the through hole 11ab passing through the analysis line CL 2.

In the stress analysis simulation, the deviation of the arrangement of the 1 st through hole 11a and the 2 nd through hole 11b was used as a parameter, and comparative example 2 and examples 2 to 9 were used. In comparative example 2, the offset was 0%, and the discontinuous portion 14 was not present. In examples 2 to 9, the offsets were 1%, 5%, 10%, 20%, 40%, 60%, 80% and 100%, respectively.

Fig. 12A shows a schematic configuration of an analysis model of comparative example 2. Fig. 12B shows a schematic configuration of an analysis model of example 9. As shown in fig. 12A, in comparative example 2, the offset was 0%, and the discontinuous portion 14 was not present. The offset is 0%, meaning that all the through holes 11 are arranged in a square lattice. In other words, comparative example 2 has a structure in which S1 is 0 μm and S2 is 12 μm in fig. 7. As shown in fig. 12B, in example 9, the offset was 100%, and the 1 st through-hole 11a and the 2 nd through-hole 11B were most offset in the discontinuous portion 14. The offset of 100% means that the structure has a structure in which S1 is 8.5 μm and S2 is 3.5 μm in fig. 7. In examples 2 to 8, the ratio of the offset was changed by increasing S1 and decreasing S2 in this order.

Fig. 13 shows an example of the stress analysis results of comparative example 2 and examples 2 to 9. As shown in fig. 13, in examples 3 to 9, the maximum principal stress in the vicinity of the analysis positions P2 and P4 was higher than that in comparative example 2. In examples 3 to 9, the number of connecting portions of the filter base 12 at the discontinuous portion 14 is larger than that of comparative example 2, and therefore stress is likely to be concentrated at the connecting portions, and breakage is likely to occur. Further, in the vicinity of the analysis position P3, the larger the rate of deviation, the smaller the value of the maximum principal stress becomes. Accordingly, it is considered that cracks and chipping are unlikely to occur in the vicinity of the analysis position P3.

As described above, when the deviation between the 1 st through hole 11a and the 2 nd through hole 11b is 5% or more, the stress at the connection portion of the filter base 12 in the discontinuous portion 14 becomes larger than that in the case where the deviation is 0%, and the breakage becomes easy.

Further, it is considered that similar stress is generated in the connection portion of the filter base body portions 12 adjacent to each other on the left and right sides of the analysis target by applying a load. Therefore, it is considered that, when the load is increased, the cracks are connected to the connecting portions of the filter base portions 12 adjacent to each other on the left and right sides, and are more likely to be broken.

In the case of example 2, the connection portion of the filter base body portion 12 in the discontinuous portion 14 is also offset in the end face in the longitudinal direction of the filter. Therefore, when cutting is performed using a scalpel and forceps after filtration, since there are gripping portions and gaps, cutting with a high probability of success of cutting or with reduced damage to the surface can be performed as compared with comparative example 2.

FIG. 14 is a graph showing the relationship between the maximum principal stresses of examples 2 to 9 based on comparative example 2. In fig. 14, the maximum principal stress of comparative example 2 and examples 2 to 9 at the analysis position P4 was used. As shown in fig. 14, the maximum principal stress values of examples 3 to 9 were increased in the order of example 3, example 4, example 5, example 6, example 7, example 9, and example 8 based on the maximum principal stress of comparative example 2. Further, although the deviation of example 8 is smaller than that of example 9, the maximum principal stress becomes large as compared with example 9.

As described above, at the analysis position P4, when the maximum principal stress of the structure with a deviation of 0% is taken as a reference, the maximum principal stress of the structure with a deviation of 5% to 100% becomes larger than that of the structure with a deviation of 0%, and the maximum principal stress becomes maximum in the structure with a deviation of 80%.

[ filtration ]

Fig. 15A shows an example of a state of filtration by using the filter 1A according to embodiment 1 of the present invention. As shown in fig. 15A, the filter 1A is attached to the side wall of the cylindrical container 41. The case 41 with the filter 1A attached thereto is disposed along a direction D4 orthogonal to the direction of gravity D3. In other words, the container 41 is disposed such that the inlet 42 of the fluid including the object to be filtered faces the direction D4 perpendicular to the gravitational direction D3. Thereby, the fluid flows toward the direction D4 inside the filter cartridge 1A, and flows in parallel along the 2 nd main face PS2 of the filter cartridge 1A. At this time, it is considered that the load mainly due to gravity and the shear stress due to the friction of the fluid are dominant in the stress applied to the discontinuous portion 14. In the example shown in fig. 15A, the influence by gravity is large. Therefore, the discontinuous portion 14 is preferably disposed above the filter 1A in the gravity direction D3. This can prevent a load in the gravity direction D3 from being applied to the discontinuous portion 14, and can prevent the discontinuous portion 14 from being broken during filtration.

Fig. 15B is a diagram showing another example of the state of filtration by using the filter 1A according to embodiment 1 of the present invention. As shown in fig. 15B, the cylindrical container 41 to which the filter 1A is attached may be disposed along the gravity direction D3. In other words, the container 41 is disposed so that the inlet 42 of the fluid containing the object to be filtered faces upward. Thereby, the fluid flows toward the same direction D5 as the gravity direction D3, and flows in parallel along the 2 nd main face PS2 of the filter remover 1A. In this manner, since the load in the gravity direction D3 is not easily applied to the discontinuous portion 14, the discontinuous portion 14 can be prevented from being broken during filtration.

In both fig. 15A and 15B, the wall surface of the connection portion of the filter base portion 12 in the discontinuous portion 14 is arranged along the direction in which the fluid flows. Therefore, the influence of the viscosity of the flow becomes dominant with respect to the shearing force applied to the discontinuous portion 14. According to newton's law of viscosity, the shear stress applied in close proximity to the wall surface is determined by the viscosity and velocity gradient. The velocity gradient can be regarded as the same straight line as the laminar flow only in the vicinity of the wall surface, and is therefore determined by the flow velocity and the circular diameter of the filter 1A. Generally, the viscosity of a liquid such as water used as a fluid is as low as several mPa/s or less. When the shear stress applied to the wall surface of the cylindrical filter 1A having a radius of 6mm was calculated, the temperature of water was controlled to 5X 10 at 20 deg.C^- ¹When m/s flowed, the pressure became about 42 mPa. Since the strength of the epoxy resin is expressed in units of several hundred MPa, even if it is applied thinly, it is considered that it is not continuous at the time of filtration as long as it is sufficiently curedThe portion 14 is less likely to be damaged.

The filter 1A may be used in a state inclined with respect to the gravity direction D3.

In the case of observation, as shown in fig. 4, the filter 1A can be cut by applying a force in the direction of cutting and peeling from the outside in order to cut the discontinuous portion 14 along the cutting line CL 1.

[ Effect ]

According to the filter 1A of embodiment 1, the following effects can be achieved.

The filter 1A is a cylindrical filter, and includes a filter base 12 defining a plurality of through holes 11 arranged in a square grid. The filter base portion 12 has a continuous portion 13 and a discontinuous portion 14, the continuous portion 13 is continuously formed in a direction D2 and a circumferential direction D1 from the 1 st opening 2 toward the 2 nd opening 3 of the filter 1A, the circumferential direction D1 is a direction along the outer periphery of the filter 1A in a cross section when the filter 1A is cut in a direction orthogonal to the direction D2 from the 1 st opening 2 toward the 2 nd opening 3 of the filter 1A, and the discontinuous portion 14 is formed by shifting a part of the continuous portion 13 in a direction D2 from the 1 st opening 2 toward the 2 nd opening 3 of the filter 1A. With such a configuration, the filter 1A is not broken by the force of the fluid during the cross-flow filtration, and can be easily cut off by applying a force from the outside after the filtration is completed. As a result, the filter object captured inside the filter 1A can be easily observed.

In this manner, the filter 1A can be easily cut by applying a force from the outside while maintaining the strength capable of withstanding filtration in the case of a cylindrical filter.

The filter base body portion 12 has a 1 st filter base body portion 12a extending in a direction D2 orthogonal to the circumferential direction D1 of the filter 1A in the discontinuous portion 14. The filter base body 12 includes a plurality of 2 nd filter base bodies 12b connected to one side of the 1 st filter base body 12a in the circumferential direction D1 of the filter 1A, and a plurality of 3 rd filter base bodies 12c connected to the other side of the 1 st filter base body 12a in the circumferential direction D1 of the filter 1A. The plurality of 1 st connecting portions 15 connecting the plurality of 2 nd filter base body portions 12b and the 1 st filter base body portion 12a and the plurality of 2 nd connecting portions 16 connecting the plurality of 3 rd filter base body portions 12c and the 1 st filter base body portion 12a are shifted in a direction D2 orthogonal to the circumferential direction D1 of the filter 1A.

With such a configuration, a plurality of 1 st connection portions 15 and a plurality of 2 nd connection portions 16 are formed in the 1 st base filter portion 12a forming the discontinuous portion 14, separately from each other. Thus, the number of connection portions can be increased in the discontinuous portion 14 as compared with the continuous portion 13, and stress is likely to be generated. As a result, the filter 1A can be cut more easily by applying a force from the outside while maintaining the strength capable of withstanding filtration in the cylindrical filter.

The plurality of 1 st connection portions 15 are respectively arranged between the adjacent plurality of 2 nd connection portions 16. With this configuration, the filter 1A can be cut more easily when a force is applied thereto from the outside.

The width of the 1 st filter base body portion 12a forming the discontinuous portion 14 is equal to the width of the filter base body portion 12 forming the continuous portion 13. With such a configuration, stress is likely to be generated when an external force is applied to the discontinuous portion 14, and the cylindrical filter 1A can be cut more easily.

The filter 1A is a membrane-shaped filter having one end E1 and the other end E2, and is formed into a cylindrical shape by joining one end E1 and the other end E2. The discontinuity 14 is formed at an engagement portion that joins the one end E1 and the other end E2. With this configuration, the discontinuous portion 14 can be easily formed, and the filter 1A can be more easily cut by applying an external force.

The filter base 12 contains at least one of a metal and a metal oxide as a main component. With such a configuration, the discontinuous portion 14 is less likely to be broken by a force due to the filtration of the fluid, and is likely to be cut when an external force is applied. That is, the filter 1A can be easily cut by applying a force from the outside while improving the mechanical strength.

The distance between the through hole 11a and the adjacent through hole 11b at the boundary surface (surface where offset occurs) between the discontinuous portion 14 and the continuous portion 13 at the position across the boundary surface can be made longer than the distance between the two adjacent through holes 11 at the positions other than the boundary surface. Although the through holes 11 and the filter base portions 12 are regularly arranged to increase the aperture ratio, the distance between the adjacent through

holes

11a and 11b can be increased by shifting the filter base portions 12a on the boundary surface, and therefore the distance between the boundary surface and the adjacent through holes 11 in the other regions can be made equal by making the filter base portions 12a on the boundary surface thin. With such a configuration, the aperture ratio is improved, and the filtration efficiency can be improved.

In embodiment 1, it is advantageous when the object to be filtered is a cell and the fluid is a cell suspension.

In embodiment 1, an example in which one end E1 and the other end E2 are joined to form a cylindrical shape of the filter 1A has been described, but the present invention is not limited to this. For example, filter 1A may be formed integrally. In other words, the continuous portion 13 and the discontinuous portion 14 may be integrally formed. For example, in the step shown in fig. 5B, the continuous portion 13 and the discontinuous portion 14 are integrated into a mold of the filter 1A by performing exposure and development processing while holding a pattern for connecting the continuous portion 13 and the discontinuous portion 14 in the same mask.

In embodiment 1, an example in which one end E1 and the other end E2 are joined to each other with epoxy resin in the filter 1A has been described, but the present invention is not limited to this. For example, one end E1 and the other end E2 may be joined by welding.

In embodiment 1, the example in which the discontinuous portion 14 is formed in the direction D2(Y direction) orthogonal to the circumferential direction D1(X direction) of the filter 1A has been described, but the present invention is not limited to this. The discontinuous portion 14 may be formed in a direction intersecting the circumferential direction D1 of the filter remover 1A. For example, the discontinuous portion 14 may be formed obliquely toward the circumferential direction D1 of the filter remover 1A. In addition, the discontinuous portion 14 may be formed in one or more than one. For example, when the filter 1A is to be separated for analysis by being put in one field of a microscope, for re-culture by being put in a six-well plate (six-well plate), or the like, the filter can be cut into filter pieces of arbitrary size after treatment by forming the discontinuous portions 14 at a plurality of locations. In this manner, one or more discontinuous portions 14 may be formed. As described above, the discontinuous portion 14 may be formed at a plurality of portions.

In embodiment 1, an example in which the cylindrical filter 1A is cut and the cut filter is placed in an optical microscope to observe a filtering object has been described, but the present invention is not limited to this. For example, the cylindrical filter 1A may be cut to collect the filter object.

In embodiment 1, an example in which the filter 1A has a cylindrical shape has been described, but the present invention is not limited to this. For example, the filter 1A may have a circular, elliptical, or polygonal tubular shape in cross section taken in a direction orthogonal to the direction D2.

(embodiment mode 2)

A filter according to embodiment 2 of the present invention will be described.

In embodiment 2, differences from embodiment 1 will be mainly described. In embodiment 2, the same or equivalent structures as those in embodiment 1 will be described with the same reference numerals. In embodiment 2, the description overlapping with embodiment 1 is omitted.

Embodiment 2 is different from embodiment 1 in that the discontinuous portion has a flat plate portion.

Fig. 16 is a schematic configuration diagram of an example of a part of a filter 1B according to embodiment 2 of the present invention. As shown in fig. 16, in the filter remover 1B, the discontinuous portion 14a has a flat plate portion 17 extending in a direction D2 perpendicular to the circumferential direction D1 of the filter remover 1B.

Specifically, the flat plate portion 17 is formed by increasing the width of the 1 st filter base portion 12a of embodiment 1. That is, the flat plate portion 17 is a part of the filter base portion 12. The flat plate portion 17 is formed between the plurality of 1 st through holes 11a and the plurality of 2 nd through holes 11b formed in the discontinuous portion 14 a. The width of the flat plate portion 17 means the length of the filter 1B in the lateral direction (X direction). The thickness of the flat plate portion 17 is equal to the thickness of the filter base body portion 12. The flat plate portion 17 is formed of the same material as the filter base portion 12.

In embodiment 2, the width of the flat plate portion 17 is 25 μm.

In the filter 1B, the 1 st through hole 11a and the 2 nd through hole 11B are arranged with the flat plate portion 17 interposed therebetween in a staggered manner. That is, the 2 nd filter base portions 12B are connected to one side of the flat plate portion 17 in the circumferential direction D1 of the filter 1B. A plurality of 3 rd filter base portions 12c are connected to the other side of the flat plate portion 17 in the circumferential direction D1 of the filter 1B.

[ stress analysis simulation ]

The results of an analysis simulation using a femt manufactured by mitani, ltd, will be described with respect to the stress generated in the discontinuous portion 14 a.

In the stress analysis simulation, stress analysis was performed using an analysis model having the same structure as that of the filter 1B. The stress analysis conditions were the same as in embodiment 1. Specifically, the offsets S1 and S2 between the 1 st through hole 11a and the 2 nd through hole 11b in the discontinuous portion 14a were adjusted, and stress analysis was performed using the comparative example 3 without offset and the examples 10 to 14 with offset. In comparative example 3, although having flat plate portion 17, the offset between 1 st through-

hole

11a and 2 nd through-hole 11b was 0%, and all through-holes 11 were arranged in a square lattice. In examples 10 to 14, in the filter 1B, the offsets between the 1 st through hole 11a and the 2 nd through hole 11B were set to 20%, 40%, 60%, 80%, and 100%, respectively.

Fig. 17 shows an example of the stress analysis results of comparative example 3 and examples 10 to 14. As shown in fig. 17, focusing on the analysis positions P2 and P4, the maximum principal stress of examples 12 to 14 becomes larger than that of comparative example 3. In other words, in the range where the deviation between the 1 st through hole 11a and the 2 nd through hole 11b of the discontinuous portion 14a is 60% or more and 100% or less, the maximum principal stress becomes larger than that in the case where the deviation is 0%. In addition, when comparative example 3 and example 14 were compared, the difference between the maximum principal stresses at the analysis positions P2 and P4 was small.

Next, in order to compare the case of having the flat plate portion 17 with the case of not having the flat plate portion 17, stress analysis simulations were performed using comparative examples 4 to 5 and examples 15 to 16. Comparative example 4 is a filter having no flat plate portion 17 and having an offset between the 1 st through hole 11a and the 2 nd through hole 11b of 0%. Comparative example 5 is a filter having a flat plate portion 17 but with an offset of 0%. Example 15 is filter remover 1A without flat plate portion 17 and offset 100%. Example 16 is a filter remover 1B having a flat plate portion 17 and an offset of 100%.

FIG. 18 shows an example of the results of stress analysis in comparative examples 4 to 5 and examples 15 to 16. Focusing on the maximum principal stresses at the analysis positions P2 and P4, the maximum principal stresses become larger in the order of comparative example 6, comparative example 5, example 16, and example 15.

[ Effect ]

According to the filter 1B of embodiment 2, the following effects can be achieved.

In the filter 1B, the discontinuous portion 14a has a flat plate portion 17 extending in a direction D2 perpendicular to the circumferential direction D1 of the cylindrical filter 1B. The width of the flat plate portion 17 is larger than the width of the filter base portion 12. With such a configuration, the strength of the discontinuous portion 14a can be increased as compared with the discontinuous portion 14 of embodiment 1. This increases the strength of the force against the fluid during filtration. On the other hand, the discontinuous portion 14a can be easily cut by applying a force from the outside. As a result, in the filter 1B, the mechanical strength of the discontinuous portion 14a can be improved and the filter can be easily cut by applying a force from the outside. That is, the filter 1B can be easily cut by applying a force from the outside while maintaining a strength capable of withstanding filtration.

Since the width of the flat plate portion 17 is larger than the width of the filter base portion 12, the regular arrangement of the plurality of through holes 11, that is, the square lattice arrangement is broken in the discontinuous portion 14 a. Therefore, stress concentration tends to occur at the joint portions of the filter base portions 12B and 12c and the flat plate portions 17, and the filter base portions 12B and 12c extend in the circumferential direction D1 of the filter 1B. This makes it possible to easily cut the filter 1B when an external force is applied to the discontinuous portion 14 a.

Further, since a thin knife such as a scalpel is inserted into the gap between the flat plate portion 17 and the container 40, the adhesive surface between the flat plate portion 17 and the container 40 can be easily peeled. This can weaken the joint of the discontinuous portion 14a, and therefore, when an external force is applied to the discontinuous portion 14a of the filter 1B, the filter can be easily cut.

The present invention has been fully described in connection with the preferred embodiments with reference to the accompanying drawings, but various modifications and alterations will become apparent to those skilled in the art. Such changes and modifications are to be understood as being included within the scope of the present invention based on the appended claims.

Industrial applicability

The filter according to the present invention is useful in, for example, the field of drug efficacy research using cells, the production of regenerative medicine, and the like because the collected substance can be easily observed.

Description of the reference numerals

1A, 1B: a filter;

2: 1 st opening;

3: a 2 nd opening;

10: a filter part;

11: a through hole;

12: a filter base portion;

12 a: 1 st filter base portion;

12 b: a 2 nd filter base body portion;

12 c: a 3 rd filter base portion;

13: a continuous portion;

14: a discontinuous portion;

15: a 1 st connecting part;

16: a 2 nd connecting part;

17: a flat plate portion;

20: a frame portion;

21: a support portion;

31: a substrate;

32: a copper thin film;

33: an intermediate layer;

34: a resist film;

35: plating a film;

36: an enhancement layer;

40: a container;

41: a container;

42: an inflow port.

Claims

1. A filter includes a cylindrical filter having a 1 st opening and a 2 nd opening opposed to the 1 st opening, wherein,

the filter includes: a filter base body portion defining a plurality of through holes arranged in a square lattice,

the filter base portion includes:

and a discontinuous section having an inflection point formed by partially shifting the continuous section in a direction from the 1 st opening toward the 2 nd opening of the filter.

2. The filter of claim 1,

the filter base body portion includes: a 1 st filter base body portion extending in the discontinuous portion in a direction from the 1 st opening toward the 2 nd opening of the filter; a plurality of 2 nd filter base body portions connected to one side of the 1 st filter base body portion in the circumferential direction of the filter; and a plurality of No. 3 filter base body portions connected to the other side of the No. 1 filter base body portion in the circumferential direction of the filter,

3. The filter according to claim 2,

the plurality of 1 st connecting parts are respectively arranged between the adjacent 2 nd connecting parts.

4. A filter according to claim 2 or 3,

the width of the 1 st filter base portion is equal to the width of the filter base portions forming the continuous portion.

5. A filter according to any one of claims 1-3, wherein,

the filter is a membrane-shaped filter having one end and the other end, and is formed into a tubular shape by joining the one end and the other end,

6. A filter according to any one of claims 1-3, wherein,

the filter base body contains at least one of a metal and a metal oxide as a main component.