CN112494415A - 一种含人乳成分的皮肤护理闪释片剂及其制备方法 - Google Patents

一种含人乳成分的皮肤护理闪释片剂及其制备方法 Download PDF

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CN112494415A
CN112494415A CN202011517427.0A CN202011517427A CN112494415A CN 112494415 A CN112494415 A CN 112494415A CN 202011517427 A CN202011517427 A CN 202011517427A CN 112494415 A CN112494415 A CN 112494415A
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陈坚
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Shandong Tianyuan Human Milk Storage Technology Development Co ltd
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Abstract

本发明公开了一种含人乳成分的皮肤护理闪释片剂及其制备方法，其包括如下重量份数的各原料：人乳100份，冻干赋形剂0.05～0.8份，皮肤调理剂0.01～0.5份，pH调节剂0～0.02份，保湿剂0～0.5份，辅助成分0～0.01份。本发明结合低温冷冻干燥技术和单片剂充氮或真空密封包装技术制成的闪释片剂，使营养成分不会发生变性或失去生物活力，遇水后可以迅速吸水崩解，且产品中无需添加抗氧化剂、防腐剂等，属于绿色温和护肤品。

Description

一种含人乳成分的皮肤护理闪释片剂及其制备方法
技术领域
本发明属于美容化妆领域，具体涉及一种含人乳成分的皮肤护理闪释片剂及其制备方法。
背景技术
研究认定，人乳中富含多种人源性复合生长因子(如EGE、FGF、KGF)、活性酶、维生素、免疫蛋白等活性物质，可以有效对抗人体自由基，修复受损浅表皮层纤维细胞，调节体表多种细胞生理功能和代谢活动，促进皮肤新陈代谢，起到抗衰老、美白、滋养等作用。传统的化妆品生产工艺是将皮肤有益成分与各种稳定剂、乳化剂、防腐剂、抗氧化剂等成分混合，再经高温乳化。许多有益成分在高温下势必会有破坏，同时添加了诸如防腐剂、抗氧化剂等一些化学物质，对皮肤有刺激作用，会造成皮肤瘙痒、刺痛、过敏等现象。一些新的化妆品生产工艺开始采用冷冻干燥技术，得到冻干粉。但是冻干粉生产过程均是先将冻干液装入西林瓶或是安瓿瓶中，装入量有限，冻干耗时较长。而且西林瓶或安瓿瓶在开启时，铝箔片易刮伤皮肤，瓶中也会残留有部分，导致有效成分不能彻底的被利用。
发明内容
基于上述现有技术所存在的不足之处，本发明提供一种含人乳成分的皮肤护理闪释片剂及其制备方法，以期获得更优的护肤效果。
本发明为实现发明目的，采用如下技术方案：
一种含人乳成分的皮肤护理闪释片剂，其特点在于，所述皮肤护理闪释片剂包括如下重量份数的各原料：人乳100份，冻干赋形剂0.05～0.8份，皮肤调理剂0.01～0.5份，pH调节剂0～0.02 份，保湿剂0～0.5份，辅助成分0～0.01份。
优选的，所述人乳为经过离心去除脂肪成分的脱脂乳。
优选的，所述冻干赋形剂为微晶纤维素、瓜尔胶、D-甘露糖醇、山梨糖醇、葡萄糖和多聚果糖中的至少一种。
优选的，所述皮肤调理剂为小分子肽、寡肽-1、烟酰胺、超氧化物歧化酶、神经酰胺-1、天然植物提取物、基肽-3000和胶原氨基酸类中的至少一种。
优选的，所述pH调节剂为氨甲基丙醇、三乙醇胺、柠檬酸钠和碳酸氢钠中的至少一种。
优选的，所述保湿剂为乳酸钠、聚谷氨酸钠、透明质酸钠、甘油和乙酰壳糖胺中的至少一种。
优选的，所述辅助成分为香精和透皮吸收促进剂中至少一种。
本发明所述皮肤护理闪释片剂的制备方法，包括以下步骤：
步骤1、将人乳与冻干赋形剂、皮肤调理剂、pH调节剂、保湿剂及辅助成分混合均匀，获得混合液；
步骤2、将所述混合液加入到冻干成型模具中，冷冻干燥，然后脱模、包装，即获得含人乳成分的皮肤护理闪释片剂。
优选的，所述人乳在与其余原料混合前先进行巴氏杀菌，或混料后进行巴氏杀菌。
优选的，步骤2中，所述冷冻干燥是在真空度10～30Pa的条件下进行，包括预冻、升华干燥和解析干燥三个过程：
预冻：降温至-50℃～-45℃，恒温1～3h；
升华干燥：经9～12h升温至10℃，恒温3～4小时；
解析干燥：经1～2h升温至35℃，恒温3～5小时。
优选的，所述包装为单片剂充氮或真空密封包装，可为袋装方式或是铝箔板装入方式。
优选的，混合液加入到冻干成型模具时，可采用精确定量的移液管、移液枪、自动加样机等移液装置。
优选的，所述冻干成型模具可为任意性质，如模具中可含有圆形、心形、方形或其他形状的孔或槽，孔或槽内底面或内边缘也可以刻有不同类型图案。控制不同形状的模具槽或孔内的液面高度为0.3-2.3cm。
优选的，冻干成型模具由导热性良好的无毒无害材质制成，如不锈钢、铸铁、铝或高分子材料等。
与已有技术相比，本发明的有益效果体现在：
1、本发明含人乳成分的皮肤护理闪释片剂，结合低温冷冻干燥技术和单片剂充氮或真空密封包装技术：低温冷冻干燥技术可避免传统化妆品生产工艺中高温乳化的缺点，使人乳中热敏性物质、活性物质等营养成分不会发生变性或失去生物活力，同时使皮肤护理剂成分稳定性更佳、活性更高、渗透性更好，从而大幅度提高肌肤对有益成分的吸收，达到理想的护肤效果；通过低温冷冻干燥技术，还可以使闪释片剂中富含大量微孔和孔道，遇水后可以迅速吸水崩解，加入溶媒后可迅速崩解、溶解完全。单独充氮包装技术，使得产品中无需添加抗氧化剂、防腐剂等，属于绿色温和护肤品，尤其适用敏感性皮肤。
2、本发明的皮肤护理闪释片剂为单颗独立包装，携带方便、储存条件比较随意，而冻干粉因为每瓶装量较多，一瓶一般要用几次，需要放在冰箱中冷藏保存，否则就会容易变质。
具体实施方式
为使本发明的上述目的、特征和优点能够更加明显易懂，下面对本发明的具体实施方式做详细的说明。以下内容仅仅是对本发明的构思所做的举例和说明，所属本技术领域的技术人员对所描述的具体实施案例做各种各样的修改或补充或采用类似的方式代替，只要不偏离发明的构思或者超越本权利要求书所定义的范围，均应属于本发明的保护范围。
下述实施例所得皮肤护理闪释片剂的评价方法如下：
实施例1
步骤1、从冷冻柜中取出母乳并解冻，然后经过离心去除脂肪成分，离心转速为3000rpm、离心时间为10min，得到脱脂乳。
取脱脂乳1000g，倒入巴氏杀菌锅中，62.5℃巴氏杀菌30分钟，然后加入0.8g瓜尔胶、 1.2g多聚果糖、2g烟酰胺，搅拌溶解均匀，获得混合液。
步骤2、将混合液加入到冻干成型模具中，模具孔为直径2.2cm的圆形，每个圆孔加入2.6mL 混合液，共加入300个孔。将模具转入冻干机隔板上，进行冷冻干燥。冷冻干燥后脱模、单片剂充氮包装，即获得300片皮肤护理闪释片剂。
其中，冷冻干燥是在真空度20Pa的条件下进行，包括预冻、升华干燥和解析干燥三个过程：
预冻：降温至-45℃，恒温2h；
升华干燥：经9h升温至10℃，恒温3小时；
解析干燥：经1h升温至35℃，恒温4小时。
经测试，本实施例所得皮肤护理闪释片剂的性能如下：将单片剂投入装有10mL 37℃水的试管中，摇晃几下即可完全溶解，溶解时间约为3-5秒，静止1分钟，试管底部无明显不溶物；制剂在包装、保存、运输的过程中片剂不开裂、不脱粉；表面平整光滑、致密，加入溶媒后可迅速溶解完全。使用时，取一片加水或其它溶媒用手指调成溶液，手指蘸取涂于使用部位即可，洁肤后使用。产品配方中添加美白成分烟酰胺，同时结合人乳中的特有护肤成分，可以补充肌肤需要的营养，并达到提亮肤色、减少细纹的效果，令肌肤更富有健康活力。
实施例2
步骤1、从冷冻柜中取出母乳并解冻，然后经过离心去除脂肪成分，离心转速为3000rpm、离心时间为10min，得到脱脂乳。
取脱脂乳1000g，倒入巴氏杀菌锅中，62.5℃巴氏杀菌30分钟，然后加入2.1g微晶纤维素、 1.2g多聚果糖、1.5g寡肽-1、1g胶原氨基酸类，搅拌溶解均匀，获得混合液。
步骤2、将混合液加入到冻干成型模具中，模具孔为直径2.2cm的圆形，每个圆孔加入2.6mL 混合液，共加入300个孔。将模具转入冻干机隔板上，进行冷冻干燥。冷冻干燥后脱模、单片剂充氮包装，即获得300片皮肤护理闪释片剂。
其中，冷冻干燥是在真空度20Pa的条件下进行，包括预冻、升华干燥和解析干燥三个过程：
预冻：降温至-45℃，恒温2h；
升华干燥：经9h升温至10℃，恒温3小时；
解析干燥：经1h升温至35℃，恒温4小时。
经测试，本实施例所得皮肤护理闪释片剂的性能如下：将单片剂投入装有10mL 37℃水的试管中，摇晃几下即可完全溶解，溶解时间约为3-5秒，静止1分钟，试管底部无明显不溶物；制剂在包装、保存、运输的过程中片剂不开裂、不脱粉；表面平整光滑、致密，加入溶媒后可迅速溶解完全。使用时，取一片加水或其它溶媒用手指调成溶液，手指蘸取涂于使用部位即可，洁肤后使用。产品配方中添加肌肤护理成分寡肽-1和胶原氨基酸类，同时结合人乳中的特有护肤成分，可以抚平毛孔，激发肌肤活力，加速着受损细胞愈合，对粉刺炎症皮肤有止痒、安抚作用，还可促进痤疮疮口的愈合、减少瘢痕去除痘印、抗衰。
实施例3
步骤1、从冷冻柜中取出母乳并解冻，然后经过离心去除脂肪成分，离心转速为3000rpm、离心时间为10min，得到脱脂乳。
取脱脂乳1000g，倒入巴氏杀菌锅中，62.5℃巴氏杀菌30分钟，然后加入3g D-甘露糖醇、2.1g微晶纤维素、0.6g神经酰胺-1、1.5g聚谷氨酸钠、1.6g甘油搅拌溶解均匀，获得混合液。
步骤2、将混合液加入到冻干成型模具中，模具孔为直径2.2cm的圆形，每个圆孔加入2.6mL 混合液，共加入300个孔。将模具转入冻干机隔板上，进行冷冻干燥。冷冻干燥后脱模、单片剂充氮包装，即获得300片皮肤护理闪释片剂。
其中，冷冻干燥是在真空度20Pa的条件下进行，包括预冻、升华干燥和解析干燥三个过程：
预冻：降温至-45℃，恒温2h；
升华干燥：经9h升温至10℃，恒温3小时；
解析干燥：经1h升温至35℃，恒温4小时。
经测试，本实施例所得皮肤护理闪释片剂的性能如下：将单片剂投入装有10mL 37℃水的试管中，摇晃几下即可完全溶解，溶解时间约为3-5秒，静止1分钟，试管底部无明显不溶物；制剂在包装、保存、运输的过程中片剂不开裂、不脱粉；表面平整光滑、致密，加入溶媒后可迅速溶解完全。使用时，取一片加水或其它溶媒用手指调成溶液，手指蘸取涂于使用部位即可，洁肤后使用。产品配方中添加保湿成分神经酰胺-1、聚谷氨酸钠和甘油，同时结合人乳中的特有护肤成分，能快速滋润补充水分，令粗糙、出现细纹的肌肤获得弹性，并紧实肌肤。
以上仅为本发明的示例性实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内所做的任何修改，等同替换和改进等，均应包含在本发明的保护范围之内。

Claims (10)

1.一种含人乳成分的皮肤护理闪释片剂，其特征在于，所述皮肤护理闪释片剂包括如下重量份数的各原料：人乳100份，冻干赋形剂0.05～0.8份，皮肤调理剂0.01～0.5份，pH调节剂0～0.02份，保湿剂0～0.5份，辅助成分0～0.01份。
2.根据权利要求1所述的一种含人乳成分的皮肤护理闪释片剂，其特征在于：所述人乳为脱脂乳。
3.根据权利要求1所述的一种含人乳成分的皮肤护理闪释片剂，其特征在于：所述冻干赋形剂为微晶纤维素、瓜尔胶、D-甘露糖醇、山梨糖醇、葡萄糖和多聚果糖中的至少一种。
4.根据权利要求1所述的一种含人乳成分的皮肤护理闪释片剂，其特征在于：所述皮肤调理剂为小分子肽、寡肽-1、烟酰胺、超氧化物歧化酶、神经酰胺-1、天然植物提取物、基肽-3000和胶原氨基酸类中的至少一种。
5.根据权利要求1所述的一种含人乳成分的皮肤护理闪释片剂，其特征在于：所述pH调节剂为氨甲基丙醇、三乙醇胺、柠檬酸钠和碳酸氢钠中的至少一种。
6.根据权利要求1所述的一种含人乳成分的皮肤护理闪释片剂，其特征在于：所述保湿剂为乳酸钠、聚谷氨酸钠、透明质酸钠、甘油和乙酰壳糖胺中的至少一种。
7.根据权利要求1所述的一种含人乳成分的皮肤护理闪释片剂，其特征在于：所述辅助成分为香精和透皮吸收促进剂中至少一种。
8.一种权利要求1～7中任意一项所述皮肤护理闪释片剂的制备方法，其特征在于，包括以下步骤：
步骤1、将人乳与冻干赋形剂、皮肤调理剂、pH调节剂、保湿剂及辅助成分混合均匀，获得混合液；
步骤2、将所述混合液加入到冻干成型模具中，冷冻干燥，然后脱模、包装，即获得含人乳成分的皮肤护理闪释片剂。
9.根据权利要求8所述的制备方法，其特征在于：步骤2中，所述冷冻干燥是在真空度10～30Pa的条件下进行，包括预冻、升华干燥和解析干燥三个过程：
预冻：降温至-50℃～-45℃，恒温1～3h；
升华干燥：经9～12h升温至10℃，恒温3～4小时；
解析干燥：经1～2h升温至35℃，恒温3～5小时。
10.根据权利要求8所述的制备方法，其特征在于：所述包装为单片剂充氮或真空密封包装。
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Publication number Priority date Publication date Assignee Title
CN102462665A (zh) * 2010-11-18 2012-05-23 董玲 冻干赋形制剂的制备方法
CN110037978A (zh) * 2019-06-06 2019-07-23 山东天源人乳库科技发展有限公司 一种添加有人乳脂组合物的化妆品或护肤品制剂及其制备方法
CN110075054A (zh) * 2019-06-06 2019-08-02 山东天源人乳库科技发展有限公司 一种来源于人乳的人源性生长因子修复制剂及其制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102462665A (zh) * 2010-11-18 2012-05-23 董玲 冻干赋形制剂的制备方法
CN110037978A (zh) * 2019-06-06 2019-07-23 山东天源人乳库科技发展有限公司 一种添加有人乳脂组合物的化妆品或护肤品制剂及其制备方法
CN110075054A (zh) * 2019-06-06 2019-08-02 山东天源人乳库科技发展有限公司 一种来源于人乳的人源性生长因子修复制剂及其制备方法

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