CN112471158A - Medical instrument concentrated disinfectant containing complex chlorine and preparation method thereof - Google Patents
Medical instrument concentrated disinfectant containing complex chlorine and preparation method thereof Download PDFInfo
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- CN112471158A CN112471158A CN202011332793.9A CN202011332793A CN112471158A CN 112471158 A CN112471158 A CN 112471158A CN 202011332793 A CN202011332793 A CN 202011332793A CN 112471158 A CN112471158 A CN 112471158A
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Abstract
The invention discloses a medical apparatus concentrated disinfectant containing complex chlorine, which comprises the following components in percentage by weight: 0.5-5% of sodium dichloroisocyanurate, 5-15% of sodium metasilicate, 1-10% of sodium tripolyphosphate, 1-10% of boron nitride, 2-10% of complexing agent, 1-5% of corrosion inhibitor, 0.5-5% of stabilizer, 0.1-1% of pH regulator and deionized water; the invention also discloses a preparation method of the medical apparatus concentrated disinfectant containing the complex chlorine, which comprises the following steps: heating and mixing sodium dichloroisocyanurate, sodium metasilicate, sodium tripolyphosphate, boron nitride, complexing agent and corrosion inhibitor at 60-70 ℃ for 1-3 hours according to the components and the content, cooling, adding stabilizing agent and pH regulator, adding water to 100%, and uniformly mixing to obtain the medical instrument concentrated disinfectant containing the complex chlorine. The invention can be diluted into various concentrations, can kill various germs and viruses, and has the advantages of high efficiency, broad spectrum, quick sterilization, persistent sterilization, good safety and simple and convenient use.
Description
Technical Field
The invention relates to the field of medical instrument cleaning agents, in particular to a medical instrument concentrated disinfectant containing complex chlorine, and in particular relates to a medical instrument concentrated disinfectant containing complex chlorine and a preparation method thereof.
Background
For the disinfection and sterilization of medical instruments, the traditional chemical disinfection and sterilization agents such as glutaraldehyde, o-phthalaldehyde, peracetic acid and the like have long disinfection time, large smell and corrosiveness and are obviously limited in the using process. The glutaraldehyde disinfectant has drug resistance to mycobacterium bisecting, the o-phthalaldehyde disinfectant cannot achieve a sterilization effect when the using concentration is low, and the peracetic acid disinfectant has low stability and is corroded.
Complexing chlorine: the process of combining molecules or ions with metal ions to form new stable ionic groups is called complexation, and generally refers to compounds containing complex chloride ions.
The sterilization mechanism of the complex chlorine is as follows: HOCl molecules are continuously released into the solution and keep dynamic balance, the HOCl molecules are small and uncharged, can easily penetrate through cell membranes of microorganisms to enter the solution, nascent state [ O ] and [ Cl ] are released, the oxidation effect and the chlorination effect are strong, amino acids in the microorganisms can be decomposed, the amino acid chains are broken, and the proteins lose functions, so that the microorganisms can be rapidly killed.
Disclosure of Invention
Aiming at the defects of the prior art, the invention utilizes the sterilization principle of complex chlorine, can play a role of rapid sterilization, basically has no corrosion to metals such as carbon steel, copper, aluminum and the like under the use concentration, has no toxicity, carcinogenic and teratogenic effects on human bodies, and has no stimulation to skin and mucosa under the use concentration.
In order to achieve the purpose, the technical scheme provided by the invention is as follows:
a medical apparatus concentrated disinfectant containing complex chlorine comprises the following components: sodium dichloroisocyanurate, sodium metasilicate, sodium tripolyphosphate, boron nitride, complexing agent, corrosion inhibitor, stabilizer, pH regulator and water.
The concentrated disinfectant solution for medical instruments containing chlorine complex as claimed in claim 1, wherein the weight percentages of the components are as follows:
0.5 to 5 percent of sodium dichloro isocyanurate;
5-15% of sodium metasilicate;
1-10% of sodium tripolyphosphate;
1-10% of boron nitride;
2-10% of complexing agent;
1-5% of corrosion inhibitor;
0.5-5% of stabilizer;
0.1-1% of pH regulator;
88.9 to 39 percent of water.
The complexing agent is composed of one or more of sodium tripolyphosphate, boron nitride, sodium hydroxide and EDTA-2 Na.
The corrosion inhibitor is one or more of sodium silicate, pentaerythritol ester, sodium metasilicate and borate.
The stabilizing agent is one or more of sodium silicate, sodium metasilicate, sodium phosphate, magnesium silicate and sodium nitrite.
The pH regulator is one or more of caustic soda, benzotriazole, sodium carbonate, lime, limestone and dolomite.
The invention also provides a preparation method of the medical apparatus concentrated disinfectant containing the complex chlorine, which is characterized by comprising the following steps:
step 1: according to the content and the components, 0.5-5% of sodium dichloroisocyanurate, 5-15% of sodium metasilicate, 1-10% of sodium tripolyphosphate, 1-10% of boron nitride, 2-10% of complexing agent and 1-5% of corrosion inhibitor are heated and mixed in sequence to form a solution;
step 2: after the solution formed in the step 1 is cooled, sequentially adding 0.5-5% of a stabilizer and a pH regulator;
and step 3: and (3) adding the balance of water into the solution formed in the step (3) to ensure that the overall mass percentage of the solution reaches 100%, and uniformly mixing to obtain the medical instrument concentrated disinfectant containing the complex chlorine.
In the step 1, the components are mixed and heated, and the heating temperature is as follows: 60-70 ℃.
After the main components are uniformly mixed, deionized water is added to ensure that the whole weight percentage of the solution reaches 100 percent, and the solution is uniformly stirred.
The medical apparatus concentrated disinfectant containing the complex chlorine can be diluted into various concentrations, and the disinfectant with different concentrations can kill intestinal pathogenic bacteria, pyogenic coccus, pathogenic yeast and bacterial spores and inactivate viruses.
The medical instrument concentrated disinfectant containing the complex chlorine is convenient to use, and can be used for diluting a medical instrument stock solution by 1:4, achieving sterilization within 30 minutes and achieving high-level sterilization within 5 minutes. The stock solution of the medical apparatus is diluted by 1:10, and high-level disinfection is achieved in 10 minutes.
The medical apparatus concentrated disinfectant containing the complex chlorine can kill intestinal pathogenic bacteria, pyogenic coccus, pathogenic yeast and bacterial spores and inactivate viruses. Not only has high efficiency, broad spectrum, quick sterilization and long-lasting effect, but also has good safety and simple and convenient and quick use. Is suitable for high-level disinfection and sterilization of various endoscopes, medical instruments, dialysis machines and the like in medical and health institutions.
Detailed Description
The present invention will be described in further detail with reference to the following examples in order to clarify technical problems, technical solutions, implementation processes and performance displays.
Example 1
As an embodiment of the invention, the medical apparatus concentrated disinfectant containing complex chlorine consists of sodium dichloroisocyanurate, a complexing agent, a corrosion inhibitor, a stabilizer, a pH regulator, sodium metasilicate, sodium tripolyphosphate, boron nitride and deionized water.
As a possible embodiment, the concentrated disinfectant for medical instruments containing complex chlorine comprises the following components in percentage by weight:
sodium dichloroisocyanurate: 2 percent;
sodium metasilicate: 8 percent;
sodium tripolyphosphate: 5 percent;
boron nitride: 10 percent;
complexing agent: 7 percent;
corrosion inhibitor: 2 percent;
a stabilizer: 1 percent;
pH regulator: 0.5 percent;
water: 69.5 percent.
Wherein the complexing agent is one or more of sodium tripolyphosphate, boron nitride, sodium hydroxide and EDTA-2Na
Wherein, the corrosion inhibitor is one or more of sodium silicate, sodium metasilicate, pentaerythritol ester and borate.
Wherein the stabilizer is one or more of sodium silicate, sodium metasilicate, sodium phosphate, magnesium silicate and sodium nitrite.
Wherein the pH regulator is one or more of caustic soda, benzotriazole, sodium carbonate, lime, limestone and dolomite.
As a possible embodiment, the method for preparing the concentrated disinfectant solution according to this embodiment includes the following steps:
step 1: according to the content and the components, 2 percent of sodium dichloroisocyanurate, 8 percent of sodium metasilicate, 5 percent of sodium tripolyphosphate, 10 percent of boron nitride, 7 percent of complexing agent and 2 percent of corrosion inhibitor are heated and mixed in sequence to form a solution;
step 2: after the solution formed in the step 1 is cooled, sequentially adding 1% of stabilizer and 0.5% of pH regulator;
and step 3: and (3) adding the balance of water into the solution formed in the step (3) to ensure that the overall mass percentage of the solution reaches 100%, and uniformly mixing to obtain the medical instrument concentrated disinfectant containing the complex chlorine.
In the step 1, the components are mixed and heated, and the heating temperature is as follows: 60-70 ℃.
Wherein, after the main components are uniformly mixed, deionized water is added to ensure that the whole weight percentage of the solution reaches 100 percent, and the solution is uniformly stirred.
The medical instrument concentrated disinfectant containing the complex chlorine is convenient to use, and can be used for diluting a medical instrument stock solution by 1:4, achieving sterilization within 30 minutes and achieving high-level sterilization within 5 minutes. The stock solution of the medical apparatus is diluted by 1:10, and high-level disinfection is achieved in 10 minutes.
According to the detection report of Jiangsu Suzhou medicine science and technology limited company:
1) for this example 1, results of the mouse acute oral toxicity test:
| sex | Dosage (mg/kg. bw) | Animal number (only) | Number of dead animals | Mortality (%) |
| Female | 5000 | 10 | 0 | 0 |
| Male sex | 5000 | 10 | 0 | 0 |
And (5) concluding that the test sample belongs to a non-toxic grade.
2) For this example 1, the micronucleus test was performed on mouse bone marrow pleochromocytes:
and (4) conclusion: the test samples had no micronucleus effect on mouse myelophilous red blood cells.
3) For example 1, the detection of irritability:
the results show that: the stimulation intensity in this example was non-irritating.
Example 2
As an embodiment of the invention, the medical apparatus concentrated disinfectant containing complex chlorine consists of sodium dichloroisocyanurate, a complexing agent, a corrosion inhibitor, a stabilizer, a pH regulator, sodium metasilicate, sodium tripolyphosphate, boron nitride and deionized water.
As a possible embodiment, the medical apparatus concentrated disinfectant containing complex chlorine comprises the following components in percentage by weight:
sodium dichloroisocyanurate: 3 percent;
sodium metasilicate: 5 percent;
sodium tripolyphosphate: 7 percent;
boron nitride: 7 percent;
complexing agent: 2 percent;
corrosion inhibitor: 5 percent;
a stabilizer: 0.5 percent;
pH regulator: 0.1 percent;
water: 70.4 percent.
Wherein the complexing agent is one or more of sodium tripolyphosphate, boron nitride, sodium hydroxide and EDTA-2 Na.
Wherein, the corrosion inhibitor is one or more of sodium silicate, sodium metasilicate, pentaerythritol ester and borate.
Wherein the stabilizer is one or more of sodium silicate, sodium metasilicate, sodium phosphate, magnesium silicate and sodium nitrite.
Wherein the pH regulator is one or more of caustic soda, benzotriazole, sodium carbonate, lime, limestone and dolomite.
As a possible embodiment, the method for preparing the concentrated disinfectant solution according to this embodiment includes the following steps:
step 1: according to the content and the components, 3 percent of sodium dichloroisocyanurate, 5 percent of sodium metasilicate, 7 percent of sodium tripolyphosphate, 7 percent of boron nitride, 2 percent of complexing agent and 5 percent of corrosion inhibitor are heated and mixed in sequence to form a solution;
step 2: after the solution formed in the step 1 is cooled, sequentially adding 0.5% of stabilizer and 0.1% of pH regulator;
and step 3: and (3) adding the balance of water into the solution formed in the step (3) to ensure that the overall mass percentage of the solution reaches 100%, and uniformly mixing to obtain the medical instrument concentrated disinfectant containing the complex chlorine.
In the step 1, the components are mixed and heated, and the heating temperature is as follows: 60-70 ℃.
Wherein, after the main components are uniformly mixed, deionized water is added to ensure that the whole weight percentage of the solution reaches 100 percent, and the solution is uniformly stirred.
The medical instrument concentrated disinfectant containing the complex chlorine is convenient to use, and can be used for diluting a medical instrument stock solution by 1:4, achieving sterilization within 30 minutes and achieving high-level sterilization within 5 minutes. The stock solution of the medical apparatus is diluted by 1:10, and high-level disinfection is achieved in 10 minutes.
According to the detection report of Jiangsu Suzhou medicine science and technology limited company:
1) for this example 2, mice acute oral toxicity test results:
| sex | Dosage (mg/kg. bw) | Animal number (only) | Number of dead animals | Mortality (%) |
| Female | 5000 | 10 | 0 | 0 |
| Male sex | 5000 | 10 | 0 | 0 |
And (5) concluding that the test sample belongs to a non-toxic grade.
2) For this example 2, the micronucleus test was performed on mouse bone marrow pleochromocytes:
and (4) conclusion: the test samples had no micronucleus effect on mouse myelophilous red blood cells.
3) For this example 2, the detection of irritability:
the results show that: the stimulation intensity in this example was non-irritating.
Example 3
As an embodiment of the invention, the medical apparatus concentrated disinfectant containing complex chlorine consists of sodium dichloroisocyanurate, a complexing agent, a corrosion inhibitor, a stabilizer, a pH regulator, sodium metasilicate, sodium tripolyphosphate, boron nitride and deionized water.
As a possible embodiment, the medical apparatus concentrated disinfectant containing complex chlorine comprises the following components in percentage by weight:
sodium dichloroisocyanurate: 4 percent;
sodium metasilicate: 15 percent;
sodium tripolyphosphate: 10 percent;
boron nitride: 2 percent;
complexing agent: 10 percent;
corrosion inhibitor: 1 percent;
a stabilizer: 3 percent;
pH regulator: 1 percent;
water: 54 percent.
Wherein the complexing agent is one or more of sodium tripolyphosphate, boron nitride, sodium hydroxide and EDTA-2 Na.
Wherein, the corrosion inhibitor is one or more of sodium silicate, sodium metasilicate, pentaerythritol ester and borate.
Wherein the stabilizer is one or more of sodium silicate, sodium metasilicate, sodium phosphate, magnesium silicate and sodium nitrite.
Wherein the pH regulator is one or more of caustic soda, benzotriazole, sodium carbonate, lime, limestone and dolomite.
As a possible embodiment, the method for preparing the concentrated disinfectant solution according to this embodiment includes the following steps:
step 1: according to the content and the components, 4 percent of sodium dichloroisocyanurate, 15 percent of sodium metasilicate, 10 percent of sodium tripolyphosphate, 2 percent of boron nitride, 10 percent of complexing agent and 1 percent of corrosion inhibitor are heated and mixed in sequence to form a solution;
step 2: after the solution formed in the step 1 is cooled, sequentially adding 3% of stabilizing agent and 1% of pH regulator;
and step 3: and (3) adding the balance of water into the solution formed in the step (3) to ensure that the overall mass percentage of the solution reaches 100%, and uniformly mixing to obtain the medical instrument concentrated disinfectant containing the complex chlorine.
In the step 1, the components are mixed and heated, and the heating temperature is as follows: 60-70 ℃.
Wherein, after the main components are uniformly mixed, deionized water is added to ensure that the whole weight percentage of the solution reaches 100 percent, and the solution is uniformly stirred.
The medical instrument concentrated disinfectant containing the complex chlorine is convenient to use, and can be used for diluting a medical instrument stock solution by 1:4, achieving sterilization within 30 minutes and achieving high-level sterilization within 5 minutes. The stock solution of the medical apparatus is diluted by 1:10, and high-level disinfection is achieved in 10 minutes.
According to the detection report of Jiangsu Suzhou medicine science and technology limited company:
1) for this example 3, results of the mouse acute oral toxicity test:
| sex | Dosage (mg/kg. bw) | Animal number (only) | Number of dead animals | Mortality (%) |
| Female | 5000 | 10 | 0 | 0 |
| Male sex | 5000 | 10 | 0 | 0 |
And (5) concluding that the test sample belongs to a non-toxic grade.
2) For this example 3, the micronucleus test was performed on mouse bone marrow pleochromocytes:
and (4) conclusion: the test samples had no micronucleus effect on mouse myelophilous red blood cells.
3) For this example 3, the detection of irritancy:
the results show that: the stimulation intensity in this example was non-irritating.
As a possible implementation mode, the medical instrument concentrated disinfectant containing the complex chlorine can be diluted into various concentrations, can kill intestinal pathogenic bacteria, pyogenic coccus, pathogenic yeast and bacterial spores, and can inactivate viruses. Not only has high efficiency, broad spectrum, quick sterilization and long-lasting effect, but also has good safety and simple and convenient and quick use. Is suitable for high-level disinfection and sterilization of various endoscopes, medical instruments, dialysis machines and the like in medical and health institutions.
Having described embodiments of the present disclosure, the foregoing description is intended to be exemplary, not exhaustive, and not limited to the disclosed embodiments. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The terms used herein were chosen in order to best explain the principles of the embodiments, the practical application, or technical improvements to the techniques in the marketplace, or to enable others of ordinary skill in the art to understand the embodiments disclosed herein.
Claims (9)
1. A medical apparatus concentrated disinfectant containing complex chlorine comprises the following components: sodium dichloroisocyanurate, sodium metasilicate, sodium tripolyphosphate, boron nitride, complexing agent, corrosion inhibitor, stabilizer, pH regulator and deionized water; the weight percentage of each component is as follows:
0.5 to 5 percent of sodium dichloro isocyanurate;
5-15% of sodium metasilicate;
1-10% of sodium tripolyphosphate;
1-10% of boron nitride;
2-10% of complexing agent;
1-5% of corrosion inhibitor;
0.5-5% of stabilizer;
0.1-1% of pH regulator;
88.9 to 39 percent of deionized water.
2. The concentrated disinfectant for medical instruments containing chlorine complex as claimed in claim 1, wherein said complexing agent is one or more selected from sodium tripolyphosphate, boron nitride, sodium hydroxide, EDTA-2 Na.
3. The concentrated disinfectant for medical instruments containing chlorine complex as claimed in claim 1, wherein said corrosion inhibitor is one or more selected from the group consisting of sodium silicate, pentaerythritol ester, sodium metasilicate and borate.
4. The concentrated disinfectant solution for medical instruments containing chlorine complex as claimed in claim 1, wherein said stabilizer is one or more of sodium silicate, sodium metasilicate, sodium phosphate, magnesium silicate and sodium nitrite.
5. The concentrated disinfectant for medical instruments containing chlorine complex according to claim 1, wherein the pH regulator is one or more of caustic soda, benzotriazole, sodium carbonate, lime, limestone and dolomite.
6. A preparation method of a medical instrument concentrated disinfectant containing complex chlorine is characterized by comprising the following steps:
step 1: according to the content and the components, 0.5-5% of sodium dichloroisocyanurate, 5-15% of sodium metasilicate, 1-10% of sodium tripolyphosphate, 1-10% of boron nitride, 2-10% of complexing agent and 1-5% of corrosion inhibitor are heated and mixed in sequence to form a solution;
step 2: after the solution formed in the step 1 is cooled, sequentially adding 0.5-5% of a stabilizer and a pH regulator;
and step 3: and (3) adding the balance of water into the solution formed in the step (3) to ensure that the overall mass percentage of the solution reaches 100%, and uniformly mixing to obtain the medical instrument concentrated disinfectant containing the complex chlorine.
7. The method for preparing the rapid sterilizing agent for the medical devices as claimed in claim 7, wherein in the step 1, the components are mixed and heated at the temperature of: 60-70 ℃, heating time: 1-3 hours.
8. The method for preparing a rapid sterilizing agent for medical instruments as claimed in claim 7, wherein after the main components are uniformly mixed, deionized water is added to make the total weight percentage of the solution to 100%, and the solution is uniformly stirred.
9. The method for preparing the concentrated disinfectant for medical instruments containing chlorine complex as claimed in claim 7, wherein the concentrated disinfectant for medical instruments containing chlorine complex can be diluted into various concentrations, and the disinfectant with different concentrations can kill intestinal pathogenic bacteria, pyogenic cocci, pathogenic yeasts and bacterial spores and inactivate viruses.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114766509A (en) * | 2022-05-16 | 2022-07-22 | 深圳市玛斯特威科技开发有限公司 | Aviation disinfectant and preparation method thereof |
| CN115152777A (en) * | 2022-08-01 | 2022-10-11 | 山东利尔康医疗科技股份有限公司 | Chlorine-containing disinfection powder for disinfection and sterilization of endoscope and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1052986A (en) * | 1990-01-06 | 1991-07-17 | 李久春 | First, hepatitis type B virus, venereal disease disinfectant |
-
2020
- 2020-11-24 CN CN202011332793.9A patent/CN112471158A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1052986A (en) * | 1990-01-06 | 1991-07-17 | 李久春 | First, hepatitis type B virus, venereal disease disinfectant |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114766509A (en) * | 2022-05-16 | 2022-07-22 | 深圳市玛斯特威科技开发有限公司 | Aviation disinfectant and preparation method thereof |
| CN115152777A (en) * | 2022-08-01 | 2022-10-11 | 山东利尔康医疗科技股份有限公司 | Chlorine-containing disinfection powder for disinfection and sterilization of endoscope and preparation method thereof |
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