CN112461822A - Automated functional material biochemical synthesis workstation based on artificial intelligence - Google Patents
Automated functional material biochemical synthesis workstation based on artificial intelligence Download PDFInfo
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Abstract
The invention relates to an automated functional material biochemical synthesis workstation based on artificial intelligence, which comprises a desktop robot hardware platform and an intelligent control analysis center which is in communication connection with the desktop robot hardware platform and comprises a database and software; the desktop robot hardware platform is provided with a raw material area, a reaction area, a test area, an evaluation area and a video monitoring area, the intelligent control analysis center can drive the three-axis mechanical arm to drive the liquid-transferring gun to prepare raw materials in the raw material area, the raw materials can also be injected into the porous reaction plate and the porous microporous plate to supply a visual module below the reaction area, the test detector in the test area and the evaluation detector in the evaluation area acquire data, the intelligent control analysis center calculates, analyzes and learns the data, the high-throughput test, the test and the iterative optimization function material are calculated and output according to a preset model, the closed loop of 'design-test-characterization-learning-redesign' is completed quickly, at low cost and in a multi-cycle manner, and the preparation and the digital manufacturing of novel function materials are realized.
Description
Technical Field
The invention relates to the technical field of research and development of high-throughput functional materials, in particular to a biochemical synthesis test workstation based on artificial intelligence and robot combined digital manufacturing and automatic screening, preparation, characterization and testing of novel functional materials.
Background
The traditional research and development process of the functional material has high cost and long time consumption, has high requirements on the efficiency and repeatability of the experiment, and the low efficiency and waste of the experiment can be great consumption on research cost and talents. Relying on manual operation alone is time-consuming and prone to error, which greatly affects the repeatability of experimental results. On the other hand, the conventional method has obvious defects in the relationship of predicting the characteristics and components of the material, processing conditions and the like. In addition, some toxic solid reagents have great risks in the process of extracting and weighing samples, which may not only cause harm to laboratory staff, but also cause uncontrollable pollution to the environment.
The rapid development of novel functional materials in the fields of energy environmental protection, electronic information, biomedical technology and intersection thereof is started, a solid theoretical basis and technical support are provided for the development of strategic emerging industries such as energy, information, high-end equipment manufacturing and human health, the development of the novel materials is changed from a traditional mode of scientific intuition and trial and error to a new mode of theoretical prediction and experimental verification, the speed of the functional materials from discovery to application is comprehensively improved, and the cost is reduced.
Disclosure of Invention
The invention aims to realize human-artificial intelligence-robot cooperation through data driving, machine learning and a machine platform, and provides an automatic functional material biochemical synthesis workstation based on artificial intelligence in a synergistic manner.
The technical scheme for solving the problems is as follows: an automatic functional material biochemical synthesis workstation based on artificial intelligence is characterized in that:
the system comprises a desktop robot hardware platform and an intelligent control analysis center which is in communication connection with the desktop robot hardware platform and comprises a database and software;
the desktop robot hardware platform is provided with a raw material area, a reaction area, a test area, an evaluation area, a vision module and a video monitoring module,
the raw material area is used for storing raw materials,
the reaction zone is a reaction platform and a raw material extraction device,
the test zone contains a test detection instrument,
the evaluation area comprises an evaluation detector and an evaluation detector,
the intelligent control analysis center controls the raw material extraction device to extract raw materials in the raw material area, the raw materials are sent to the reaction platform to be prepared, a sample is obtained, the intelligent control analysis center controls the raw material extraction device to extract the sample to the test area, a test detection instrument of the test area detects and analyzes the sample, the sample detected by the test area is conveyed to the evaluation area through the conveying device, an evaluation detector in the evaluation area collects and analyzes data of the sample to be detected, and the raw material area, the reaction area, the test area and the evaluation area are monitored by the video monitoring module and upload monitoring information to the intelligent control analysis center;
the vision module comprises an illumination photographing device, the illumination photographing device is used for collecting images of samples in the reaction area and transmitting the collected images to an intelligent control analysis center, the intelligent control analysis center can collect data collected by the illumination photographing device, the test detector and the evaluation detector and upload the data to a database in the intelligent control analysis center, the data are calculated, analyzed and machine-learned through software, and calculation results are output according to a preset model in the software, so that high-flux tests are realized.
Furthermore, the number of the raw material areas is multiple, the number of the reaction platforms is multiple, and the raw material areas and the reaction subareas are arranged at intervals.
Further, above-mentioned raw materials extraction element includes the triaxial arm, be equipped with the pipette on the triaxial arm, reaction platform includes the transparent porous reaction plate of a plurality of, be equipped with a plurality of reaction holes on the porous reaction plate, the bottom of the reaction hole has overlapped the rubber sleeve, the rubber sleeve bottom still is equipped with the hole, the porous reaction plate downside is equipped with the illumination device of shooing.
Furthermore, the upper sides of the reaction zone and the raw material zone are also provided with a temperature sensor and an environment temperature regulator.
Further, be equipped with a plurality of former feed boxes in the above-mentioned raw materials district for place different stoste and/or raw materials, former feed box is transparent cuboid form, just former feed box upper end opening, it is right that former feed box downside still is equipped with the illumination device of shooing former feed box shoots and collects data.
Further, above-mentioned illumination device of shooing includes the shadowless lamp, the shadowless lamp is installed on the desktop robot hardware platform, the shadowless lamp middle part is equipped with the stand, the camera has been inlayed to stand upper end.
Furthermore, a vibration motor is arranged on the side edge of the reaction area.
Further, above-mentioned test detector is box-like, just test detector upper portion bottom is equipped with a plurality of monochromatic light transmitting heads, the transmitting head downside is equipped with receiving sensor, receiving sensor both sides still are equipped with the conveying running roller.
Furthermore, a conveying roller is also arranged on the platform at the outer side of the test detector, a plurality of transparent porous micro-porous plates are also arranged on the conveying roller on the platform at the outer side, and the test area is connected with the evaluation area through the conveying roller.
Furthermore, the evaluation detector comprises a plurality of detection heads, wherein a receiving plate is arranged on the lower side of each detection head, a sensor is arranged in each receiving plate, conveying rollers are also arranged on two sides of each receiving plate, and the porous microporous plate is conveyed between the test area and the evaluation area through the conveying rollers.
Furthermore, the evaluation area is connected with a waste collecting area through a conveying roller, the waste collecting area comprises a waste collecting area groove, and the waste collecting groove is rectangular.
The invention has the advantages that:
the invention relates to an automatic functional material testing device based on artificial intelligence, which carries out text mining, material gene acquisition, high-throughput calculation, machine learning, data analysis, material model establishment and the like on functional materials, namely application layers (carrying out database establishment, material query, component optimization, functional optimization and the like on materials in the fields of energy environmental protection, electronic information, biomedicine and the like) by a hardware layer, namely a desktop robot hardware platform and relying on the software layer (PYTHON, PYMATGEN, FACTSAE, AFLOW, VASP and the like), obtains the material genes by text mining the functional materials through the artificial intelligence, further carries out high-throughput (i.e. a large number of repeated operations in a short time) test and a series of detection calculation through the device, leads the device to carry out deeper optimization test and optimize the material ratio through the self-learning of an artificial intelligence program built in the device, finally, the required materials are obtained or calculated or analyzed, so that the cost and time consumption are saved, the research and development of the functional materials which originally can be completed for years and even decades can be shortened to months, and in addition, the design can be realized through the free combination of all the partition modules, so that the research and development of biological medicines can be realized, the research and development of materials in the aspects of electronic information, energy environmental protection and the like can be realized, and guidance data can be provided.
Drawings
FIG. 1 is an overall operational schematic of the present invention;
FIG. 2 is a detailed view of the main structure of the present invention;
FIG. 3 is a schematic side view of the main structure of the present invention;
FIG. 4 is a schematic top view of the main structure of the present invention;
FIG. 5 is a schematic view of a pipette according to the present invention;
FIG. 6 is a schematic view of the installation position of the multi-hole reaction plate and the illumination photographing device according to the present invention;
FIG. 7 is a schematic view of an illumination photographing apparatus according to the present invention;
FIG. 8 is a schematic view of a multi-well reaction plate according to the present invention;
FIG. 9 is a schematic view of a multi-well reaction plate according to another aspect of the present invention;
FIG. 10 is a schematic view of the test area workflow of the present invention;
FIG. 11 is a schematic view of a test meter according to the present invention;
FIG. 12 is a schematic view of the transfer of a multi-well microplate according to the invention;
FIG. 13 is a schematic view of a workspace of the present invention;
FIG. 14 is a schematic view of an evaluation test apparatus according to the present invention;
fig. 15 is a flow chart of the operation of the present invention.
1. A desktop robot hardware platform, 2, a three-axis mechanical arm, 3, an environment temperature regulator, 4, a temperature sensor, 5, a pipette, 6, a micro pump, 7, a first raw material area, 8, a raw material box, 9, a first reaction area, 10, a second raw material area, 12, a second reaction area, 13, a vibration motor, 14, a porous microporous plate, 15, a conveying roller, 16, a test area, 17, a waste collecting tank, 18, a lighting and photographing device, 19, a stand column, 20, a shadowless lamp, 21, a porous reaction plate, 22, a reaction hole, 23, a rubber sleeve, 24, a hole, 25, an evaluation area, 26, a receiving plate, 27, a receiving sensor, 28, a monochromatic light emitting head, 29, a detection head, 30, a sensor, 31, a camera, 32, a test detector, 33, an evaluation detector, 35 and a video monitoring module.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings of the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention. Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention.
Referring to fig. 1 to 4, an automated functional material biochemical synthesis workstation based on artificial intelligence comprises a modular automated desktop robot hardware platform 1, an intelligent control analysis center containing a database and software. The desktop robot hardware platform 1 is provided with a raw material area, a reaction area, a test area, an evaluation area and a video monitoring module 35.
The desktop robot hardware platform is provided with a raw material area, a reaction area, a test area, an evaluation area, a vision module and a video monitoring module.
The material area is internally provided with at least one material stock solution, the reaction area comprises a reaction platform and a material extraction device, the test area comprises a test detection instrument, and the evaluation area comprises an evaluation detection instrument.
The intelligent control analysis center controls the raw material extraction device to extract raw materials in the raw material area and sends the raw materials to the reaction platform for preparation to obtain a sample, the intelligent control analysis center controls the raw material extraction device to extract the sample to the test area, a test detection instrument of the test area detects and analyzes the sample, the sample detected by the test area is conveyed to the evaluation area through the conveying device, an evaluation detector in the evaluation area carries out data acquisition and analysis on the sample to be detected, and the raw material area, the reaction area, the test area and the evaluation area are all monitored by the video monitoring module and upload monitoring information to the intelligent control analysis center.
The vision module comprises an illumination photographing device, the illumination photographing device is used for carrying out image acquisition on the sample in the reaction area and conveying the acquired image to the intelligent control analysis center. The software layer comprises an intelligent control analysis center, the intelligent control analysis center can acquire data acquired by the illumination photographing device, the test detector and the evaluation detector, upload the data to a database in the intelligent control analysis center, perform calculation, analysis and machine learning through software, output calculation results according to a preset model in the software, and realize high-throughput tests.
The design mainly researches a functional material automatic platform (body) and a functional material interface genome project (brain) of the desktop robot, and the matching similar to the body and the brain is preliminarily realized through the top-layer design and interactive linkage of the two.
The invention uses a hardware layer, namely a desktop robot hardware platform, to rely on a software layer (PYTHON, PYMATGEN, FACTSAE, AFLOW, VASP and other software) on the hardware layer to perform text mining, material gene acquisition, high-throughput calculation, machine learning, data analysis, material model establishment and the like on functional materials, namely an application layer (database establishment, material query, component optimization, function optimization and the like on materials in the fields of energy environmental protection, electronic information, biomedicine and the like), to acquire material genes by text mining on the functional materials through artificial intelligence, the device can be used for carrying out high-throughput (namely, a large number of repeated operations in a short time) tests and a series of detection calculations, and carrying out deeper optimization tests and optimizing material proportioning by self-learning of an artificial intelligence program built in the device, and finally obtaining or calculating or analyzing the required materials.
As a preferred embodiment of the present invention, the raw material extraction apparatus includes a three-axis mechanical arm 2 and a plurality of pipette guns 5 connected to the three-axis mechanical arm 2, the three-axis mechanical arm 2 is driven to control the pipette guns 5 below the three-axis mechanical arm 2 to perform corresponding operations on each partition on the desktop robot hardware platform 1, and an individual micro pump 6 is arranged above each row of the pipette guns 5, as shown in fig. 5, the individual micro pumps 6 perform a refined liquid sucking and discharging operation on each pipette gun 5.
The raw materials district includes raw materials district one 7 or raw materials district two 10, the reaction platform includes reaction zone one 9 or reaction zone two 12, raw materials district one 7 or raw materials district two 10 with reaction zone one 9 or reaction zone two 12 interval sets up, the reaction zone with raw materials district upside still is equipped with temperature sensor 4 and ambient temperature regulator 3. Through temperature sensor 4 with ambient temperature regulator 3 can regulate and control the inside ambient temperature of this device (heat up and heat or cool down and cool off), the purpose that the interval set up is stagger respectively to a plurality of raw materials district one 7 or raw materials district two 10 and a plurality of reaction zone one 9 or reaction zone two 12: the raw material areas I7 or the raw material areas II 10 and the reaction areas I9 or the reaction areas II 12 can be freely combined to carry out formula preparation combination, and prepared raw materials and prepared samples are stored in a classified mode, so that the test steps are simplified.
As a preferred embodiment of the present invention, as shown in fig. 2, 3 and 4, a plurality of raw material boxes 8 are disposed on the first raw material area 7 or the second raw material area 10, and different raw liquids and/or raw materials are placed in the raw material boxes 8, the raw material boxes 8 are in a transparent rectangular parallelepiped shape, and an illuminating and photographing device 18 is further disposed on a lower side of the raw material boxes 8. The above-mentioned raw material box 8 is transparent and the purpose of setting up the illumination device 18 of shooing below lies in: the raw material box 8 can be photographed and uploaded in real time through the lighting photographing device 18, and the raw materials in the raw material box 8 or the prepared samples can be monitored through a background intelligent control analysis center.
The raw material areas I7 and II 10 can be used as raw material containing areas and carriers for formula preparation, one or more raw material boxes 8 can be used for simultaneously preparing one or more formulas, and the formulas can be photographed in real time by the lighting photographing devices 18 below the raw material areas 10 and uploaded to a database of an intelligent control analysis center and analyzed by software in the formula preparing process, so that the preparation can be monitored.
Referring to fig. 7, the lighting photographing device 18 comprises a shadowless lamp 20, the shadowless lamp 20 is mounted on the desktop robot hardware platform 1, a column 19 is arranged in the middle of the shadowless lamp 20, and a camera 31 is embedded in the upper end of the column 19.
As shown in fig. 6, 7, 8, and 9, a plurality of transparent porous reaction plates 21 are disposed on the first reaction zone 9 or the second reaction zone 12, a plurality of reaction holes 22 are disposed on the porous reaction plates 21, rubber sleeves 23 are sleeved at bottoms of the reaction holes 22, holes 24 are further disposed at bottoms of the rubber sleeves 23, and the illumination photographing device 18 is also disposed at a lower side of the porous reaction plates 21.
The purpose of the illumination photographing device 18 arranged below the porous reaction plate 21 is to: the multi-hole reaction plate 21 is photographed and uploaded in real time through the lighting photographing device 18, and the bottom of the reaction hole 22 of the multi-hole reaction plate 21 is sleeved with a rubber sleeve 23, and the rubber sleeve 23 is provided with a hole 24 so that when the illumination photographing device 18 takes a photograph, the image difference between the holes is more obvious, and in addition, the shadowless lamp 20 in the illumination photographing device 18 can prevent the light rays from influencing each other when the reaction holes 22 of the multi-hole reaction plate 21 are photographed due to the difference of the light rays when the reaction holes 22 are photographed so as to cause the situation that the photographic image can present more shadows, the original shadow is covered by the shadowless lamp 20 to make the real-time shot picture clearer, meanwhile, the color reaction generated in the porous reaction plate 21 can be distinguished by the intelligent control analysis center of the background more conveniently, so that machine learning is more conveniently carried out.
As a preferred embodiment of the present invention, referring to fig. 2, a vibration motor 13 is further disposed at a side edge of the second reaction zone 12 at an edge of the desktop robot hardware platform 1. The above-mentioned vibrating motor 13 is provided for the purpose of: the vibration motor 13 is driven to vibrate, so that the mixing of the raw materials in the second reaction zone 12 is accelerated, and the time required by the test is shortened.
As shown in fig. 2, fig. 10, fig. 11, fig. 12, the test area 16 includes a test detector 32, the test detector 32 is an instrument that can test the developed functional materials, such as a microplate reader, and the test detector 32 is connected to the intelligent control analysis center through an external interface, the test detector 32 is box-shaped, the bottom end of the upper portion of the test detector 32 is provided with a plurality of monochromatic light emitting heads 28, a receiving sensor 27 is arranged on the lower side of the emitting heads 28, conveying rollers 15 are further arranged on two sides of the receiving sensor 27, conveying rollers 15 are also arranged on the platform outside the test detector 32, a plurality of transparent porous micro-porous plates 14 are further arranged on the conveying rollers 15 on the platform outside, and the test area 16 is connected to the evaluation area 25 through the conveying rollers 15.
As shown in fig. 10, in the embodiment of the present invention, the multi-well microplate 14 absorbs the sample to be tested in the multi-well reaction plate 21 by the pipette gun 5 through the three-axis robot arm 2, adds the sample to the well of the multi-well microplate 14, and conveys the sample to the lower side of the test detector 32 through the conveying roller 15, the monochromatic light emitting head 28 on the test detector 32 emits monochromatic light to pass through the sample to be tested on the multi-well microplate 14 and irradiate the receiving sensor 27, the receiving sensor 27 converts the received signal into an electrical signal and uploads the electrical signal to the database of the intelligent control analysis center, and the data analysis is performed by software in the intelligent control analysis center.
As shown in fig. 13 and 14, in the embodiment of the present invention, the evaluation area 25 includes an evaluation detector 33, the evaluation detector 33 is also connected to the intelligent control analysis center through an external interface, the evaluation detector 33 is a professional instrument capable of performing characterization analysis on functional materials, the evaluation detector 33 includes a detection head 29, a receiving plate 26 is disposed on a lower side of the detection head 29, a sensor 30 is disposed in the receiving plate 26, transfer rollers 15 are disposed on two sides of the receiving plate 26, and the multi-well plate 14 is transferred between the test area 16 and the evaluation area 25 through the transfer rollers 15.
The multi-hole microporous plate 14 is detected by the test zone 16, then is transmitted into the evaluation zone 25 through the transmission roller 15 and is transmitted to the lower part of the evaluation detector 33, the detection head 29 emits detection light, the detection light penetrates through the multi-hole microporous plate 14 and is received by the sensor 30 on the receiving plate 26, the sensor 30 converts the received signal into an electric signal and uploads the electric signal to the database of the intelligent control analysis center, and the data analysis is performed by software in the database.
In a preferred embodiment of the present invention, the evaluation area 25 is further connected to a garbage collection tank 17 through a conveying roller 15, the garbage collection tank 17 is rectangular, and a reaction plate collection and TIP detachment collection device can be arranged in the garbage collection tank 17. The porous microporous plate 14 is detected by the test area 16 and the evaluation area 25, and then is conveyed to the waste collecting tank 17 by the conveying roller 15 for collection and then is treated uniformly.
The specific use method of the design is as follows:
firstly, raw materials required for functional material research and development are respectively placed in raw material boxes 8 of a plurality of raw material areas I7 or raw material areas II 10 of the raw material areas, according to a preliminary formula given in the intelligent analysis center, software in the intelligent analysis center is used for operating a three-axis mechanical arm 2 on the upper side of a desktop robot hardware platform 1 to carry out preliminary formula preparation, and the raw materials and the formula materials in each raw material box 8 can be photographed and uploaded in real time through a lighting photographing device 18 of a vision module on the lower side of the raw material box 8 and are analyzed by the intelligent control analysis center, so that the purity of the raw materials in the raw material box 8, the residual degree of the raw materials and the preliminary color reaction of a sample prepared in the raw material box 8 are monitored.
Then driving a triaxial mechanical arm 2 at the upper side of the desktop robot hardware platform 1 to move so that the pipette 5 extends into a raw material box 8 of required raw materials and quantitatively absorbs the raw materials through a micro pump 6 at the upper part of the pipette 5, then driving the triaxial mechanical arm 2 to release the absorbed raw materials into a reaction hole 22 of the porous reaction plate 21 and mix and stir the raw materials through repeated suction of the pipette 5, repeating the steps to absorb the raw materials and carry out proportioning reaction in the porous reaction plate 21, carrying out real-time photographing on color reaction in the porous reaction plate 21 through an illumination photographic device 18 below the porous reaction plate 21, uploading the color reaction to a database of an intelligent control analysis center and analyzing the color reaction by software, carrying out classification learning on reaction results, and carrying out a short-time repeated high-throughput test through a machine, the data center can obtain a large amount of test data in a short time, and further can better evaluate the test data, so that the test can be further optimized according to a model preset by software.
Then, the triaxial mechanical arm 2 is driven to absorb and release the alternative materials in the porous reaction plate 21 which are processed, analyzed and screened by the intelligent control analysis center into the porous microporous plate 14, the porous microporous plate 14 with the sample to be detected is conveyed to the lower part of the test detector 32 through the conveying roller 15, the test detector 32 detects the alternative materials, and the detection result of the test detector 32 is sent to the background intelligent control analysis center for analysis through the receiving sensor 27.
After the porous microporous plate 14 with the sample to be tested and detected by the test detector 32 is detected by the test area 16, the porous microporous plate is further conveyed to the position below the evaluation detector 33 of the evaluation area 25 by the conveying roller 15, the evaluation detector 33 detects the suspension degree, the nano particle size and the like, and similarly, the detection result is converted into a signal by the sensor 30 and is sent to the intelligent control analysis center for analysis.
The porous microplate 14 finally detected by the above-mentioned test zone 16 and evaluation zone 25 is conveyed by the conveying roller 15 into the waste collection tank 17 to be further processed.
After the steps, the intelligent control analysis center obtains a group of material genes, uploads the material genes to the database and continues to design and optimize the ratio by analyzing data calculation through corresponding software, so that the steps are repeated, a closed loop from 'design-test-characterization-learning-redesign' is formed, and the machine automatically optimizes the ratio of raw materials and performs automatic ratio detection by combining mechanical automation and artificial intelligence big data analysis learning, so that the manual use is reduced, the time consumption for researching and developing novel functional materials is reduced, and the cost of each aspect is saved.
In addition, the raw material area of the design is mainly used for placing liquid consumables and the like and carrying out preliminary formula reaction on functional materials such as enzyme catalysis, protein crystallization, electronic ink and the like; a temperature sensor 4 of the heating area and an environment temperature regulator 3 are mainly used for regulating and controlling the temperature of the whole device and testing the thermal stability, the photosensitive degree, the quantum dots and the like of the material; the reaction zone is mainly used as a reaction platform of biochemical reaction and catalytic reaction in the research and development process of functional materials, the visual module comprises an illumination photographing device 18, the zone mainly photographs the reaction generated in the reaction zone and the raw material zone and uploads the photographed reaction to an intelligent control analysis center for image analysis for machine learning, the video monitoring module 35 mainly comprises a camera thereon, the camera photographs the reaction and uploads the photographed reaction to the intelligent control analysis center for integral video monitoring by software, the test evaluation zone comprises a test zone 16 and an evaluation zone 25, the zone mainly connects commercial equipment such as a microplate reader, a suspension degree analyzer and a nanometer particle size analyzer through an external interface to perform professional test evaluation on the functional materials, thereby evaluating the specific application value of the functional materials, the waste zone comprises a waste collecting tank 17, and the zone mainly collects consumable waste generated in the test through each collecting device (prior art) arranged on the zone, through the flexible combination of each partition module, the design can be used for the research and development of biomedicine, and also can be used for the research and development of electronic information, energy environment-friendly materials and the like, for example, protein crystallization operation is carried out, originally, a protein sample is injected into a porous plate through a pipette, the manual operation is time-consuming and labor-consuming and is easy to generate cross contamination, so that the test fails, the protein sample tested in the porous plate needs to be tested and detected after the protein sample is injected into the porous plate, the process needs to be finished manually, not only the steps are complicated, but also the possibility of pollution is provided, so that the detection result is inaccurate, in a workstation of the design, the crystallization operation on the protein can be finished automatically by issuing instructions by an intelligent control analysis center so as to finish each step including the crystallization of the protein, detection, and the like.
In summary, the specific work flow of the design can be summarized as shown in fig. 15, the development steps of the functional material are subdivided into four flows of preparation, reaction, test and evaluation, wherein the preparation area and the reaction area are provided with specific visual modules for real-time photographing and uploading to an intelligent control analysis center for evaluation learning in aspects of color and the like, the two flows of test and evaluation are implemented by professional detection instruments such as a microplate reader for professional test evaluation of enzyme-linked immunosorbent assay, material turbidity, material nanoparticle size and the like on the material, and the detected data of each group are uploaded to the intelligent control analysis center for synthesis, and the data (namely, functional material gene data) of the material test are recorded by the intelligent control analysis center, and the test is further optimized by a software program analysis comparison optimization formula, and re-optimizing according to a preset model and re-sending instructions to each module of the design to perform optimization tests, thereby performing closed loop of 'design-test-representation-learning-re-design' and realizing novel functional material preparation and digital manufacturing.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all equivalent structures or equivalent flow transformations made by using the contents of the specification and the drawings, or applied directly or indirectly to other related systems, are included in the scope of the present invention.
Claims (12)
1. An automatic functional material biochemical synthesis workstation based on artificial intelligence, its characterized in that:
the system comprises a desktop robot hardware platform and an intelligent control analysis center which is in communication connection with the desktop robot hardware platform and comprises a database and software;
the desktop robot hardware platform is provided with a raw material area, a reaction area, a test area, an evaluation area, a vision module and a video monitoring module;
the raw material area is used for storing raw materials, the reaction area comprises a reaction platform and a raw material extraction device, the test area comprises a test detection instrument, and the evaluation area comprises an evaluation detector;
the intelligent control analysis center controls the raw material extraction device to extract raw materials in the raw material area, the raw materials are sent to the reaction platform to be prepared, a sample is obtained, the intelligent control analysis center controls the raw material extraction device to extract the sample to the test area, a test detection instrument of the test area detects and analyzes the sample, the sample detected by the test area is conveyed to the evaluation area through the conveying device, an evaluation detector in the evaluation area collects and analyzes data of the sample to be detected, and the raw material area, the reaction area, the test area and the evaluation area are monitored by the video monitoring module and upload monitoring information to the intelligent control analysis center;
the vision module comprises an illumination photographing device, the illumination photographing device is used for collecting images of samples in the reaction area and transmitting the collected images to an intelligent control analysis center, the intelligent control analysis center can collect data collected by the illumination photographing device, the test detector and the evaluation detector and upload the data to a database in the intelligent control analysis center, the data are calculated, analyzed and machine-learned through software, and calculation results are output according to a preset model in the software, so that high-flux tests are realized.
2. The automated functional material biochemical synthesis workstation based on artificial intelligence of claim 1, wherein:
the quantity of raw materials district is a plurality of, the quantity of reaction platform is a plurality of, raw materials district and reaction platform interval set up.
3. The automated functional material biochemical synthesis workstation based on artificial intelligence of claim 1, wherein:
the raw material extraction device comprises a triaxial mechanical arm, wherein a liquid transfer gun is arranged on the triaxial mechanical arm, and the liquid transfer guns are respectively connected through corresponding micro pumps.
4. The automated functional material biochemical synthesis workstation based on artificial intelligence of claim 1, wherein:
the reaction platform comprises a plurality of transparent porous reaction plates, a plurality of reaction holes are formed in the porous reaction plates, rubber sleeves are sleeved at the bottoms of the reaction holes, holes are further formed in the bottoms of the rubber sleeves, and the lighting photographing device is arranged on the lower side of the porous reaction plates.
5. An automated functional material biochemical synthesis workstation based on artificial intelligence according to any one of claims 1-4, characterized by:
the temperature control system further comprises a temperature sensor and an environment temperature regulator, the environment temperature regulator regulates the temperature, and the temperature sensor is used for acquiring the environment temperature.
6. An automated functional material biochemical synthesis workstation based on artificial intelligence according to any one of claims 1-4, characterized by:
be equipped with a plurality of former feed boxes in the raw materials district, former feed box is transparent cuboid form, just former feed box upper end opening, the illumination device of shooing sets up shoots raw materials box at former feed box downside and collects data.
7. An automated functional material biochemical synthesis workstation based on artificial intelligence according to any one of claims 1-4, characterized by:
the illumination device of shooing includes the shadowless lamp, the shadowless lamp is installed on the desktop robot hardware platform, the shadowless lamp middle part is equipped with the stand, the camera has been inlayed to stand upper end.
8. An automated functional material biochemical synthesis workstation based on artificial intelligence according to any one of claims 1-4, characterized by:
and a vibration motor is also arranged on the side edge of the reaction zone.
9. An automated functional material biochemical synthesis workstation based on artificial intelligence according to any one of claims 1-4, characterized by:
the test detector is box-like, just test detector upper portion bottom is equipped with a plurality of monochromatic light transmitting heads, the transmitting head downside is equipped with the receiving sensor, the receiving sensor both sides still are equipped with the conveying running roller.
10. An automated functional material biochemical synthesis workstation based on artificial intelligence according to any one of claims 1-4, characterized by:
the test and detection instrument is characterized in that a conveying roller is also arranged on the platform on the outer side of the test and detection instrument, a plurality of transparent porous micro-porous plates are further arranged on the conveying roller on the platform on the outer side, and the test area is connected with the evaluation area through the conveying roller.
11. An automated functional material biochemical synthesis workstation based on artificial intelligence according to any one of claims 1-4, characterized by:
the evaluation detector comprises a plurality of detection heads, wherein a receiving plate is arranged on the lower side of each detection head, a sensor is arranged in each receiving plate, conveying rollers are also arranged on two sides of each receiving plate, and the porous microporous plate is conveyed between the test area and the evaluation area through the conveying rollers.
12. An automated functional material biochemical synthesis workstation based on artificial intelligence according to any one of claims 1-4, characterized by:
the desktop robot hardware platform is provided with a waste collecting area, and the waste collecting area is connected with the evaluation area through a conveying roller.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117444948A (en) * | 2023-06-08 | 2024-01-26 | 香港量子人工智能实验室有限公司 | Automatic material synthesis system and method based on artificial intelligence and robot |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117444948A (en) * | 2023-06-08 | 2024-01-26 | 香港量子人工智能实验室有限公司 | Automatic material synthesis system and method based on artificial intelligence and robot |
| CN117444948B (en) * | 2023-06-08 | 2024-06-28 | 香港量子人工智能实验室有限公司 | Automatic material synthesis system and method based on artificial intelligence and robot |
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