CN1124144A - Full scorpion preparation for curing cardio-cerebral vascular nervous system diseases and tumor and its preparing method - Google Patents

Abstract

The single ingredient whole scorpion preparation can be made into capsules, tablets, granules or pills, its main pharmacodynamic specifications, such as anti-thrombus, are superior to that of prevailing "Hwa Tuo Zaizao Wan", it is safe and convenient, low in toxicity, and is indicated for treating cardiovascular and cerebrovascular diseases, tumor and diseases of nervous system.

Description

A kind of cardio-cerebral vascular nervous system diseases and tumor controlled

Full scorpion preparation and preparation method thereof

The present invention relates to a kind of full scorpion preparation that acts on cardiovascular and cerebrovascular vessel, nervous system disease and tumor and preparation method thereof, specifically, is oral solid formulation and the system method thereof of Scorpio.

Scorpio is a Chinese medicine, has the function " Pharmacopoeia of People's Republic of China (an one) 118 pages of nineteen nineties version " of endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.The centering air port , hemiplegia, hypertension, dizzy, headache, infantile convulsion tic spasm, epilepsy, rheumatic ostalgia etc. have sure curative effect.Chang Peiwu uses in compound recipe in clinical practice.Apoplexy is the name of disease of the traditional Chinese medical science, is equivalent to the acute cerebrovascular disease of modern medicine, comprises that brain blood is fastened, thromboembolism, cerebral hemorrhage etc.Be used for the treatment of the Chinese patent medicine of this class disease such as HUATUO ZAIZAO WAN, DAHUOLUO WAN, YANG invigorating also five oral liquids, MAILUONING ZHUSHEYE etc. in the market, be compound preparation, wherein HUATUO ZAIZAO WAN is in great demand the most.Scorpio is used for the treatment of tumor and is found in compatibility use in the prescription among the people, does not see the anticancer preparation of single Scorpio and the pharmacological research of system thereof so far.

The object of the present invention is to provide a kind ofly carry, taking convenience, the Scorpio oral solid formulation of controlling cardiovascular and cerebrovascular vessel, nervous system disease and tumor evident in efficacy.

Purpose of the present invention still is the method that a kind of raw material is single, technology simply prepares the Scorpio oral solid formulation is provided, and the control of product quality detection method is simpler than compound preparation.

Purpose of the present invention can reach by following measure: a kind of full scorpion preparation of controlling cardiovascular and cerebrovascular vessel, nervous system disease and tumor, it is characterized in that: basically by the single Scorpio as active component, can add an amount of acceptable accessories, make oral solid formulation.

The Scorpio oral solid formulation can be a capsule.

The Scorpio oral solid formulation can be a tablet.

The Scorpio oral solid formulation can be an electuary.

The Scorpio oral solid formulation can be a pill.

The preparation method of Scorpio oral solid formulation is characterized in that mainly being made up of following step: powder or the granule of (1) preparation Scorpio, and the A method is pulverized new fresh and alive scorpion after freezing in-25～-30 ℃, becomes the scorpion powder in 60 ℃ of vacuum dryings then; Perhaps freezing caked Scorpio is smashed, use water extraction in 80～95 ℃, behind the aqueous extract vacuum concentration, add appropriate amount of auxiliary materials or aforementioned scorpion powder system granule, the granule that drying obtains; The B method is made raw material with prepared slices of Chinese crude drugs Scorpio, is ground into the scorpion powder; Perhaps adopt conventional decocting method to make extractum, add appropriate amount of auxiliary materials or scorpion powder then and granulate the granule that drying obtains.(2) formulation method is made oral solid formulation with powder, extractum or granule routinely.

Described oral solid formulation can be capsule, tablet, electuary, pill.Powder or granule directly can be incapsulated; Perhaps powder or granule adding appropriate amount of auxiliary materials are pressed into tablet; Perhaps extractum is added appropriate amount of auxiliary materials or powder and make electuary or pill.

Make the pertinent regulations that various preparations meet rules of preparations in the Chinese Pharmacopoeia " appendix " by above-mentioned preparation method.Discrimination method is with the whole dactylogram of thin slice scan or with ultraviolet maximum absorption band and standard control, and content assaying method is a quantitative target with thin layer chromatography scanning or automatic amino acid analyzer mensuration with contained taurine.

The Scorpio oral solid formulation all has good action to cardio-cerebrovascular, nervous system disease and tumor.The main pharmacodynamics of Scorpio oral solid formulation studies show that it has the effect of anti-platelet aggregation, antithrombotic, reduction whole blood contrast viscosity, and it also has antitumaous effect, and it still has anticonvulsant action.Toxicological study shows that Scorpio capsule toxicity is very low.

The Scorpio oral solid formulation has good action to cardiovascular and cerebrovascular disease, and its antiplatelet aggregative activity, antithrombotic and the effect of reduction whole blood contrast viscosity etc. all are better than " HUATUO ZAIZAO WAN " salable in the market.

1. Scorpio capsule 0.95-1.7g.kg ^-1Obviously increase ICAF amount, 1.7g.kg ^-1The dosage group obviously descends the internal carotid artery vascular resistance, and with the positive control drug contrast, the dosage that reaches similar drug effect is lower, and the drug effect of prompting this product is stronger.See Table 1.

2. Scorpio capsule 0.3g.kg ^-1The drug effect and the HUATUO ZAIZAO WAN 1.0g.kg of the cerebral edema (brain water content) when group reduces cerebral ischemia ^-1Organize identically, prompting this product reduces the cerebral edema drug effect due to the ischemia, is about 3 times of positive controls.See Table 2.

3. the Scorpio capsule shows significantly to antiplatelet aggregation, 2.4g.kg ^-1Group and positive drug 4g.kg ^-1Similar.Prompting this product antiplatelet aggregative activity is better than HUATUO ZAIZAO WAN.See Table 3

4. the Scorpio capsule all has anti-effect to reaching external thrombosis in the body, is the dosage compliance.1.2g.kg ^-1Drug effect roughly with positive drug 4g.kg ^-1Similar.The anticoagulation of prompting this product also is better than HUATUO ZAIZAO WAN.See Table 4 tables 5.

5. the Scorpio capsule reduces whole blood contrast viscosity, is the dosage compliance, the specific viscosity of high shear and low-rate-of-shear is all had the reduction effect, and can reduce the specific viscosity of blood plasma, and drug effect also is better than HUATUO ZAIZAO WAN, and can reduce packed cell volume.See Table 6.Single medicine with Scorpio treatment tumor is not arranged in the market as yet, Scorpio capsule of the present invention through pharmacodynamics test to sarcoma S ₁₈₀Cancerous cell, hepatoma carcinoma cell, ehrlich ascites cell have direct killing effect, and in vivo test is to sarcoma S ₁₈₀Obvious inhibitory action is also arranged, and toxicity is very low, can be used as the auxiliary treatment life-time service of antineoplastic agent or cancer therapy drug.

1. animal: the Kunming white mice, body weight 20 ± 2 grams, ♂ ♀ dual-purpose is available from institute of materia medica, Nanjing and animal housing of China Medicine University.

2. medicine: 1. full scorpion preparation is carried by Chinese medicine institute of China Medicine University Chinese medicine preparation research department

Supply.2. cyclophosphamide---Shanghai No.12 Pharmaceutical Factory produces (lot number 810364-12)

1. in vitro tests: use Yihong staining

1. to S ₁₈₀The effect of cancerous cell:

Get 7-9 days S of inoculation ₁₈₀Ehrlich ascites carcinoma white mice, aseptic condition extract ascites fluid down, are diluted to 1: 3 solution with normal saline, with the medicine mixed in equal amounts of variable concentrations, make evenly, in 37 ℃ of incubators, cultivate, observed its red rate (dyeing of 0.5% Yihong) of dying in 1 hour, 3 hours, experimental result sees Table 7.2. to the effect of hepatic ascites cancerous cell:

Get 7-9 days hepatic ascites cancer white mice of inoculation, aseptic condition extracts ascites fluid down, be diluted to 1: 3 solution with normal saline, medicine mixed in equal amounts with variable concentrations, make evenly, cultivate in 37 ℃ of incubators, observed its red rate (dyeing of 0.5% Yihong) of dying in 1 hour, 3 hours, experimental result sees Table 8.3. to the effect of ehrlich ascites cell:

Get 7-9 days ehrlich carcinoma white mice of inoculation, aseptic condition extracts ascites fluid down, be diluted to 1: 3 solution with normal saline, medicine mixed in equal amounts with variable concentrations, make evenly, cultivate in 37 ℃ of incubators, observed its red rate (dyeing of 0.5% Yihong) of dying in 1 hour, 3 hours, experimental result sees Table 9.From table 7,8,9 as can be known, Scorpio is to S ₁₈₀, hepatic ascites cancer and ehrlich ascites cell have direct killing effect, and its action intensity increases with drug level and the prolongation of action time strengthens.

2. anti-tumor in vivo experiment:

1. to S ₁₈₀The solid tumor effect:

Get 7-9 days well-grown S of inoculation ₁₈₀Tumor liquid is diluted to the cancerous cell liquid of 1: 3 concentration with normal saline, under aseptic condition, at the cancerous cell liquid of the right fore armpit subcutaneous vaccination 0.2ml of every white mice, random packet behind the 24h, the ig administration is 9 days continuously, after the drug withdrawal, weigh next day, dissects white mice, and gained tumor piece is weighed, compare administration group and matched group tumor piece difference, and calculate tumour inhibiting rate.Formula is as follows:

Experimental result sees Table 10.

Scorpio oral liquid solid preparation also has good efficacy to nervous system disease, and the convulsion test shows that the frightened effect of causing of obvious anti-electrofit effect and anti-Coraminum is arranged in the Scorpio capsule.

The convulsion test:

1. anti-electrofit: cause frightened with the 35V alternating current, choose 40 of mices, be divided into two groups at random, 20 every group, matched group is irritated stomach to distilled water, the administration group is got the solution that the Scorpio capsule 's content is made into 1g/ml (product of giving money as a gift calculating) and is irritated stomach, successive administration 7 days, after the last administration 50 minutes, cause frightened with electricity irritation, the statistics Mus number of fainting from fear and do not faint from fear, the result group mice of taking medicine obviously reduces and causes the convulsions number, referring to table 11.

2. the convulsions of anti-Coraminum:

Get 40 of Kunming kind white mice, be divided into two groups at random, medication is identical with above-mentioned anti-electrofit with dosage, in the 3rd after administration 50 minutes, abdominal part hypodermic 1.25% Coraminum solution 0.2ml/10g caused frightened, the Scorpio capsule makes mice have the frightened effect of causing of anti-Coraminum as a result, sees Table 12.Scorpio capsule toxicological study shows that its toxicity is very low.

1. acute toxicity test:

By simplifying probability method, mice LD ₅₀＞20g/kg

Calculate 300 times that surpass the clinical application amount by total administration.

2. chronic toxicity test:

Use the rat feeding test for 90 days, the every index of hematological examination as a result and biochemical investigation is all in range of normal value.Pathological change is not found in the histopathology check yet, and its no overt toxicity reaction is described.

Below the present invention is described in further detail

The A method:

1. get new fresh and alive scorpion 1000, immerse in the water, wait to tell most earth impurity, wash down, pull out and drain, put into refrigerating chamber and freeze to death in-30 ℃, form ice cube, be broken into granular immediately, 60 ℃ of vacuum dryings are ground into fine powder again, sieve to such an extent that particle diameter is 0.15～0.17 millimeter scorpion powder 250g.

2. get new fresh and alive scorpion 1000, immerse in the water, wait to tell most earth impurity, wash down, pull out and drain, put into refrigerating chamber and freeze to death in-30 ℃, form ice cube, be broken into granular immediately, add 6 premium on currency then, extracted repeatedly in 1 hour 2 times in 90 ℃ of heating extraction, merge extractive liquid, carries out concentrating under reduced pressure in 70 ℃, until obtaining extractum 40g, extractum proportion is that 1.25/80 ℃ of heat is surveyed, and this extractum is added the above-mentioned dry scorpion powder (in 1: 1.2 ratio W/W) that makes, mixing granulation again, drying, sieve granule 135g (particle diameter is 0.18～0.35 millimeter)

The B method:

1. get commercially available prepared slices of Chinese crude drugs Scorpio 1000g, remove the impurity foreign body,, be ground into fine powder then, sieve to such an extent that particle diameter is 0.15～0.17 millimeter scorpion powder 850g in 80 ℃ of dryings through picking.

2. get commercially available prepared slices of Chinese crude drugs Scorpio 1000g, remove the impurity foreign body through picking, appropriateness is ground into the Semen phaseoli radiati size again, add 9 premium on currency then and soaked 1 hour, reheat to 95 ℃ extraction 1 hour, and extract repeatedly twice, merge extractive liquid,, handle equally by above-mentioned A method, get extractum 185g after concentrating, 1.25/80 ℃ of heat of proportion is surveyed.Again this extractum is added the scorpion powder that commercially available Chinese medicine Scorpio makes by same processing of above-mentioned A method, mixing granulation, drying, sieve granule 225g (0.18～0.35 millimeter of particle diameter)

1. capsule

(1) gets scorpion powder that the new fresh and alive scorpion of aforementioned A method the makes capsule of directly packing into No. 0, every loading amount 0.30g.The clinical practice instructions about how to take medicine: each 5, every day 3 times.

(2) get granule that aforementioned A method (or B method) the makes capsule of packing into No. 0, every loading amount 0.35g.Clinical usage: at every turn obey 2, every day 3 times.

2. tablet

Get aforementioned scorpion powder 145g that makes and extractum 120g mix mixed, drying, powder is spitted, cross No. 6 sieves with in honey be binding agent system soft material for 30 milliliters, pushed sieve No. 2, drying then, add again 3% (W/W) Pulvis Talci tremble even, tabletting, every weighs 0.5g.Clinical usage: at every turn obey 2, every day 3 times.

3. electuary

Get the aforementioned extractum 100g that makes, cane sugar powder 300g, soluble starch 150g, uniform mixing is made soft material, presses sieve No. 1, makes granule, and in 80 ℃ of oven dry, the granulate that sieves is packaged in the sealing bag, every bag of 6g.Clinical usage: at every turn obey 1 bag, every day 2 times.

4. pill

Get aforementioned extractum 100g that makes and scorpion powder 120g, honeyed pill method routinely is mixed and made into the suitable ball piece of soft or hard, extrusion then, pill, with wet granular do, sieve, glazing, coating must concentrate 750 of honeyed pill, the heavy 150g of grain.Clinical usage: at every turn obey 8, every day 2 times.

Table 1. Scorpio capsule and HUATUO ZAIZAO WAN be to dog ICBF, ICVR, MAP, SAP, the influence of DAP and HR

Medicine ICBF ICVR MAP SAP DAP HR

(g.kg ^-1) (ml.min ^-1) (KPa.ml ^-1.min ^-1) (KPa) (KPa) (KPa) (bpm) 0.5％CMC B 9.0±1.8 2.0±0.4 17.7±0.9 22.8±1.1 11.7±1.5 168±50

A 9.5 ± 3.0 2.1 ± 0.6 18.5 ± 1.7 23.0 ± 1.7 16.5 ± 2.3 165 ± 55 HUATUO ZAIZAO WAN A 8.0 ± 1.6 2.6 ± 0.6 19.0 ± 3.5 23.6 ± 4.0 16.5 ± 3.3 170 ± 46

2.6 B?12.4±2.6 ^** 1.7±0.4 ^* 19.5±2.4 24.3±2.8 16.7±1.9 173±34

Scorpio

0.81 A 7.2±1.6 2.4±0.4 16.1±2.4 20.5±2.0 13.9±2.5 180±42

B 7.2±1.3 2.3±0.5 16.1±2.8 20.1±2.1 14.1±3.2 194±44

0.95 A 8.8±1.6 2.1±0.4 18.5±3.1 22.4±4.1 16.4±3.0 205±19

B?11.2±2.6 1.8±0.3 19.6±2.4 23.3±2.8 17.4±2.3 204±32

1.7 A 8.0±2.1 2.3±0.3 18.2±3.0 22.9±2.9 16.3±2.6 204±22

B 11.8 ± 1.8 ^*1.5 ± 0.2 ^*17.2 ± 2.6 21.2 ± 2.9 15.2 ± 2.3 207 ± 33X ± s, n=5, P＜0.01 is relatively preceding with administration, A: before the administration, B: after the administration.

Table 2. Scorpio capsule is to the influence of brain water content and cerebral index

Group (g.100g ^-1) brain water content (%) cerebral index sham operated rats 77.3 ± 0.6 0.84 ± 0.04 not treatment groups 79.1 ± 1.2 ^###1.16 ± 0.12 ^###HUATUO ZAIZAO WAN 1.0 77.6 ± 1.1 ^*0.90 ± 0.072 ^{* *}Scorpio 0.15 78.2 ± 1.0 0.96 ± 0.05 ^{* *}

0.3 78.1±1.1 0.94±0.03 ^***

0.6 76.7 ± 0.9 ^{* *}0.92 ± 0.04 ^{* *}X ≠ s, n=8, ^*P＜0.05 ^*P＜0.01 ^{* *}Compare with not treatment group P＜0.001.

^###Compare with sham operated rats P＜0.001.

Table 3. Scorpio capsule antiplatelet aggregative activity

Maximum assemble (%) of group assembled (%) gathering in the 5th minute (%) (g.kg in first minute ^-1) blank administration group blank administration group blank administration group Scorpio 0.6 41.4 24.4 38.2 22.4 30.4 18.0

±14.7 ±9.1 ^* ±12.7 ±9.6 ^* ±19.5 ±7.8 ^* 1.2 44.1 21.5 38.1 18.9 35.4 17.8

±20.1 ±9.5 ^**?±18.6 ±9.5 ^* ±25.5 ±l8.9 ^*** 2.1 44.3 11.8 42.5 9.9 31.3 4.4

± 7.5 ± 3.6 ^{* *}± 6.9 ± 4.4 ^{* *}± 7.4 ± 2.5 ^{* *}Aspirin 0.005 65.2 39.6 51.3 35.3 56.3 35.4

± 15.5 ± 18.9 ^*± 19.6 ± 18.8 ^*24.2 ± 20.0 ^*Chinaization restorative bolus 4 42.6 11.0 40.9 9.2 38.7 5.1

± 7.4 ± 2.3 ^{* *}± 6.9 ± 2.2 ^{* *}± 7.3 ± 2.8 ^{* *}X ± s, n=6, ^*P＜0.05, ^*P＜0.0 ^{* *}Compare with matched group P＜0.001.

The influence that table 4. Scorpio capsule forms thrombus in vivo

Group wet weight of thrombus thrombosis dry weight (g.kg ^-1) blank administration group blank administration group

Scorpio

0.6 330±81 186±133 ^* 83±29 47±36

1.2 302±39 119±56 ^** 94±21 36±18 ^**

2.4 274 ± 75 61 ± 23 ^{* *}112 ± 29 25 ± 9 ^{* *}Aspirin 0.005 349 ± 79 154 ± 97 ^{* *}106 ± 46 50 ± 29 ^{* *}HUATUO ZAIZAO WAN

4 245 ± 35 85 ± 37 ^{* *}108 ± 11 38 ± 19 ^{* *}X ± s, n=6, ^*P＜0.05 ^*P＜0.01 ^{* *}Compare with the photograph group P＜0.001.

Table 5. Scorpio capsule is to the influence of external thrombus

Group thrombosis length (cm) wet weight of thrombus (mg) thrombosis dry weight (mg) (g.kg ^-1) blank administration group blank administration group blank administration group

Scorpio

0.6 7.5±1.6 3.4±2.1 ^** 117±48 82±55 ^** 30±12 19±5

1.2 7.0±0.7 3.7±1.5 ^** 49±1.0 77±8 ^** 71±5 6±7 ^***

2.4 6.6 ± 0.9 0.8 ± 0.3 ^{* *}58 ± 6 16 ± 7 ^{* *}27 ± 27 ± 3 ^*An Ah Duan woods

0.005 8.0 ± 1.6 3.5 ± 2.1 ^{* *}126 ± 21 56 ± 30 ^*45 ± 22 17 ± 8 ^*HUATUO ZAIZAO WAN

4 7.4±0.7 2.6±1.1 ^*** 61±3 25±12 ^*** 28±2 10±5 ^***X±s，n＝6， ^*P＜0.05? ^**P＜0.01? ^***P＜0.001

Table 6. Scorpio capsule influences group shearing (I/s) erythrocyte (g.kg to what the rabbit whole blood specific viscosity arranged ^-1) 20 30 40 60 80 hematocrits (%) Scorpio, 0.6 blank 4.9 ± 1.2 4.6 ± 0.9 4.3 ± 0.8 4.1 ± 0.7 4.0 ± 0.8 35.9 ± 3.4

Administration group 4.3 ± 0.6 4.1 ± 0.7 ^*3.8 ± 0.5 ^*3.7 ± 0.5 ^*3.5 ± 0.5 ^*34.0 ± 3.1 ^*1.2 blank 5.9 ± 1.0 5.3 ± 0.5 5.0 ± 0.6 4.7 ± 0.4 4.6 ± 0.4 39.0 ± 3.4

Administration group 4.9 ± 0.5 ^*4.6 ± 0.3 ^*4.4 ± 0.3 ^*4.3 ± 0.2 ^*4.0 ± 0.2 ^*37.3 ± 2.72.4 blank 6.1 ± 0.6 5.6 ± 0.5 5.2 ± 0.4 4.9 ± 0.4 4.6 ± 0.4 39.8 ± 5.6

Administration group 4.8 ± 0.2 ^*4.4 ± 0.5 ^*4.1 ± 0.4 ^*3.8 ± 0.4 ^*3.6 ± 0.4 ^*33.2 ± 2.2 ^*HUATUO ZAIZAO WAN 4 blank 6.0 ± 1.6 5.2 ± 1.2 4.8 ± 1.0 4.5 ± 0.6 4.3 ± 0.5 38.7 ± 4.5

Administration group 5.1 ± 1.4 ^*4.3 ± 1.2 3.8 ± 0.8 ^*3.7 ± 0.7 ^*3.4 ± 0.5 ^*35.5 ± 5.9 aspirin 0.005 blank 6.0 ± 1.9 5.4 ± 1.5 4.9 ± 1.1 4.7 scholar 0.9 4.5 ± 0.8 37.7 ± 5.5

Administration group 4.2 ± 1.3 ^*4.0 ± 1.0 ^*3.7 ± 0.8 ^*3.5 ± 0.7 ^*3.4 ± 0.6 ^*36.0 ± 5.3 X ± s, D=6, ^*P＜0.05 ^*Compare with matched group P＜0.01.

Table 7. in vitro tests: Scorpio is to S ₁₈₀The red rate % that dyes of mg/ml number of the drugs with function concentration of cancerous cell

Mg/ml (1 hour) (3 hours) normal saline 27 10 Scorpios 10 2 50 99

2 2 12 50

0.4 2 10 15

0.04 2 8 11

Table 8. in vitro tests: Scorpio is to the red rate % that dyes of mg/ml number of drugs with function concentration of hepatic ascites cancerous cell

Mg/ml (1 hour) (3 hours) normal saline 248 Scorpios 25 2 98 99

5 2 16 80

0.5 2 9 25

0.05 2 5 11

Table 9. in vitro tests: Scorpio is to the red rate % that dyes of mg/ml number of drugs with function concentration of ehrlich ascites cell

1 hour 3 hours normal saline 234 Scorpios 25 2 96 99 of mg/ml

5 2 56 91

0.50 2 15 42

0.50 2 9 30

The in vivo test of table 10. mice: Scorpio is to S ₁₈₀Heavy (g) tumour inhibiting rate (%) normal saline of the average tumor of solid tumor cell cytosis drug dose (mg/kg) number of mice average weight (g) 34,/36 19.9/27 2.87 ± 1.23-cyclophosphamide 20 * 9 15,/15 19.8/22 0.8 ± 0.11 ^{* *}72 Scorpio 7840 * 9 13,/15 19.7/29 1.5 ± 0.8 ^{* *}17.7

3920×9 14/15 19.7/28 1.82±1.27 ^** 37

1960 * 9 15,/15 19.8/27 1.85 ± 0.6 ^*35.5 ^*P＜0.05 ^{* *}P＜0.01VS normal saline

The effect of the anti-electricity irritation convulsions of table 11. Scorpio

Mus number (only) causes the unlikely convulsions number of convulsions number (only) (only) matched group 20 20 0 administration groups 20 11 9

Table 12. Coraminum causes mice convulsion incubation period

Mus number (only) length incubation period (X ± SD second) matched group 20 115.5 ± 60.7 administration groups 20 226.3 ± 172.9

Claims (7)

1. full scorpion preparation of controlling cardiovascular and cerebrovascular vessel, nervous system disease and tumor is characterized in that: basically by the single Scorpio as active component, can add an amount of acceptable accessories and make oral solid formulation.

2. full scorpion preparation according to claim 1 is characterized in that it can being capsule.

3. full scorpion preparation according to claim 1 is characterized in that it can being tablet.

4. full scorpion preparation according to claim 1 is characterized in that it can being electuary.

5. full scorpion preparation according to claim 1 is characterized in that it can being pill.

6. the preparation method of the described full scorpion preparation of claim 1 is characterized in that mainly being made up of following step: powder, extractum and the granule of (1) preparation Scorpio, the A method, with new fresh and alive scorpion in-25～-30 ℃ freezing after, be ground into the scorpion powder, be dried into dry scorpion powder; Perhaps freezing caked bright scorpion is smashed, use water extraction in 80～95 ℃, the extracting solution concentrating under reduced pressure gets extractum, adds above-mentioned scorpion powder or appropriate amount of auxiliary materials and granulates, and drying obtains granule; The B method is made raw material with prepared slices of Chinese crude drugs Scorpio, is ground into the scorpion powder; Perhaps adopt conventional decocting method to make extractum, add appropriate amount of auxiliary materials or scorpion powder system granule then, the granule that drying obtains; (2) formulation method is made oral solid formulation with powder extractum or granule routinely.

7. the preparation method of full scorpion preparation according to claim 6 is characterized in that the oral solid formulation of making according to a conventional method can be capsule, tablet, electuary or pill.