CN112402058A - Intervention mitral valve stent - Google Patents
Intervention mitral valve stent Download PDFInfo
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- CN112402058A CN112402058A CN202011086959.3A CN202011086959A CN112402058A CN 112402058 A CN112402058 A CN 112402058A CN 202011086959 A CN202011086959 A CN 202011086959A CN 112402058 A CN112402058 A CN 112402058A
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- valve
- leaflet
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- beams
- upper portion
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- 210000004115 mitral valve Anatomy 0.000 title claims abstract description 34
- 239000000725 suspension Substances 0.000 claims abstract description 63
- 230000002980 postoperative effect Effects 0.000 claims description 4
- 206010067171 Regurgitation Diseases 0.000 claims description 2
- 230000007704 transition Effects 0.000 claims description 2
- 230000002035 prolonged effect Effects 0.000 abstract description 2
- 239000000463 material Substances 0.000 description 12
- 230000000004 hemodynamic effect Effects 0.000 description 7
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 230000005489 elastic deformation Effects 0.000 description 5
- 210000000709 aorta Anatomy 0.000 description 4
- 230000002349 favourable effect Effects 0.000 description 4
- 239000010410 layer Substances 0.000 description 4
- 210000001765 aortic valve Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000011038 discontinuous diafiltration by volume reduction Methods 0.000 description 2
- 210000002837 heart atrium Anatomy 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000012938 design process Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 229910001285 shape-memory alloy Inorganic materials 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
- A61F2/2463—Implants forming part of the valve leaflets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
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- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
The present application relates to an interventional mitral valve stent comprising an upper valve portion and a leaflet suspension portion, the upper valve portion being connected above the leaflet suspension portion, the stiffness of the upper valve portion being less than the stiffness of the leaflet suspension portion. The rigidity of the upper part of the valve on the valve support is smaller than that of the valve hanging part, so that the upper part of the softer valve can be fully attached to the valve orifice of a human body and can be naturally shaped according to the shape of the valve orifice of the human body, the occurrence of backflow can be effectively reduced, the endothelialization after operation can be accelerated, and the interventional valve can stably work in the body; meanwhile, the valve leaf hanging part has high rigidity, so that the reliability of fixing the valve leaf can be improved, the normal work of the intervention valve is ensured, and the service life is prolonged.
Description
Technical Field
The application relates to the technical field of medical equipment, in particular to an intervention mitral valve stent.
Background
Because the valve orifice of the human mitral valve is generally in a saddle shape and is not positioned on the same plane front, back, left and right, although the factors are fully considered in the design process of the intervention mitral valve, the upper part of the intervention valve can be fitted with the valve orifice of the human mitral valve as much as possible so as to reduce the perivalvular leakage and endothelialization as soon as possible, so that the intervention valve and the human body are fused into a whole. However, because of the great individual difference of human body, a shaped product is difficult to adapt to each individual shape, which may cause perivalvular leakage, and the valve can not be endothelialized or integrated with the human body, and in future life and work of the operator, the valve may be displaced or separated from the valve orifice due to improper force application, forming irretrievable results.
Because the human aorta is very close to the mitral valve and only one layer of curtain is separated, the curtain is pushed to one side of the mitral valve by blood during the period of opening the aortic valve and closing the mitral valve, so that the aorta inflow channel is more unobstructed to reduce the blood flow resistance. If the orifice of the interventional valve is too stiff, the curtain cannot be pushed to the side of the interventional valve, resulting in poor hemodynamics of the aortic valve. If the part of the intervention valve support connected with the valve leaflets is too soft, the valve leaflets can be unstably fixed, and the normal work of the intervention valve and the service life of the intervention valve are influenced.
For this reason, some manufacturers have designed the intervention valve as a two-layered stent, the inner layer being used to fix the leaflets and being relatively stiff, and the outer layer being used to fix the leaflets and being relatively soft. However, the valve has a large volume and can be implanted only by a large delivery system, so that the operation trauma is increased, and meanwhile, the opening area of the valve is small, and certain influence is also generated on the hemodynamics.
Disclosure of Invention
The application relates to an intervene mitral valve support to can realize carrying out the nature moulding according to human valve mouth shape through one deck valve frame, realize also guaranteeing that the hemodynamics is stable when valve normally works.
An object of the present application is to provide an interventional mitral valve stent, which includes a valve upper portion and a leaflet suspension portion, the valve upper portion being connected above the leaflet suspension portion, the valve upper portion having a stiffness less than that of the leaflet suspension portion to reduce the incidence of regurgitation and accelerate post-operative endothelialization;
the upper valve part and the valve leaf hanging part are both of a net structure, a plurality of net holes are formed in the net structure, and a connecting beam is formed between every two adjacent net holes;
the total cross-sectional area of the connecting beam of the upper portion of the leaflet is smaller than the total cross-sectional area of the connecting beam of the leaflet suspension portion.
In one possible implementation, the ratio between the total cross-sectional area of the connecting beams of the upper part of the leaflet and the total cross-sectional area of the connecting beams of the suspension of the leaflet ranges from 0.3 to 0.7.
In one possible implementation, the thickness of the connection beam in the leaflet suspension is not less than the thickness of the connection beam on the upper portion of the leaflet.
In one possible implementation, the width of the connection beam of the leaflet suspension is not less than the width of the connection beam of the upper portion of the leaflet.
In one possible implementation, the width or thickness of the connecting beam of the valve upper part and the width or thickness of the connecting beam of the leaflet suspension gradually transition between the valve upper part and the leaflet suspension.
In one possible implementation, the number of connecting beams of the leaflet suspension is not less than the number of connecting beams of the upper part of the leaflet.
In one possible implementation, the height of the upper part of the flap is 3-8 mm.
The technical scheme provided by the application can achieve the following beneficial effects:
the application provides an intervene mitral valve support for a single-deck valve frame, this single-deck valve frame has better elastic deformation ability, for current double-deck valve frame, this single-deck valve frame has less volume after the compression, can pack into conveying system more conveniently to implant the human body through conveying system. Simultaneously, owing to have the volume reduction of the intervention valve of the single-deck valve frame that this embodiment provided, avoided the expansion to the operation wound, intervene the relative increase of open area of valve simultaneously, be favorable to the stability of hemodynamics.
In addition, through making the rigidity on the valve upper portion on this valve support be less than the rigidity of leaflet suspension portion, make valve upper portion softer, and the rigidity of leaflet suspension portion is great relatively, comparatively non-deformable for valve upper portion, at the in-process that will intervene the valve implantation human body, can intervene the valve through conveying system and draw from the atrium to the ventricle, make softer valve upper portion can fully laminate with human valve mouth, and carry out the nature moulding according to human valve mouth shape, thereby can effectively reduce the emergence of backflowing and accelerate postoperative endothelialization, make and intervene the valve and can be at internal stable work.
In addition, the valve upper part has relatively lower rigidity and relatively higher elastic deformation capacity, so that the curtain can be pushed to one side of the interventional valve by blood more easily, and the stability of the aortic hemodynamics is ensured. Meanwhile, the valve leaf hanging part has higher rigidity relative to the upper part of the valve, so that the valve leaf hanging part is not easy to deform relatively, the reliability of fixing the valve leaf is improved, the normal work of the intervention valve is ensured, and the service life is prolonged.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the application.
Drawings
Fig. 1 is a schematic structural diagram of an interventional mitral valve stent provided in an embodiment of the present application;
FIG. 2 is a schematic representation of a deployed, post-deployment structure of an interventional mitral valve stent provided in accordance with an embodiment of the present application;
FIG. 3 is a side view of FIG. 2;
FIG. 4 is a schematic representation of a post-deployment configuration of an interventional mitral valve stent provided in accordance with another embodiment of the present application;
FIG. 5 is a side view of FIG. 4;
FIG. 6 is a schematic representation of a post-deployment configuration of an interventional mitral valve stent provided in accordance with yet another embodiment of the present application;
fig. 7 is a side view of fig. 6.
Reference numerals:
1-a valve stent;
11-lobe upper;
12-a leaflet suspension;
13-connecting the beams;
14-mesh;
h-height;
b 1-thickness;
b 2-thickness;
c 1-width;
c 2-width.
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the present application and together with the description, serve to explain the principles of the application.
Detailed Description
For better understanding of the technical solutions of the present application, the following detailed descriptions of the embodiments of the present application are provided with reference to the accompanying drawings.
It should be understood that the embodiments described are only a few embodiments of the present application, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
The terminology used in the embodiments of the present application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used in the examples of this application and the appended claims, the singular forms "a", "an", and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
It should be understood that the term "and/or" as used herein is merely one type of association that describes an associated object, meaning that three relationships may exist, e.g., a and/or B may mean: a exists alone, A and B exist simultaneously, and B exists alone. In addition, the character "/" herein generally indicates that the former and latter related objects are in an "or" relationship.
It should be noted that the terms "upper", "lower", "left", "right", and the like used in the embodiments of the present application are described in terms of the angles shown in the drawings, and should not be construed as limiting the embodiments of the present application. In addition, in this context, it will also be understood that when an element is referred to as being "on" or "under" another element, it can be directly on "or" under "the other element or be indirectly on" or "under" the other element via an intermediate element.
As shown in fig. 1 to 7, the present embodiment provides an interventional mitral valve stent including a valve upper portion 11 and a leaflet suspension portion 12, the valve upper portion 11 being connected above the leaflet suspension portion 12, the stiffness of the valve upper portion 11 being less than the stiffness of the leaflet suspension portion 12.
Wherein stiffness refers to the ability of a material or structure to resist elastic deformation when subjected to a force. In this embodiment, the stiffness is used to represent the ability of the valve upper portion 11 and the valve leaflet to resist elastic deformation when being subjected to a force, that is, the smaller the stiffness of the valve upper portion 11 or the valve leaflet is, the weaker the ability to resist deformation is, and the stronger the ability to elastically deform when being subjected to a force is.
As shown in fig. 1, the interventional mitral valve stent provided by the present embodiment is a single-layer valve stent, which has better elastic deformability, and has a smaller volume after being compressed compared to the existing double-layer valve stent, so that the single-layer valve stent can be more conveniently loaded into a delivery system and implanted into a human body through the delivery system. Simultaneously, owing to have the volume reduction of the intervention valve of the single-deck valve frame that this embodiment provided, avoided the expansion to the operation wound, intervene the relative increase of open area of valve simultaneously, be favorable to the stability of hemodynamics.
In addition, the valve frame that this embodiment provided, rigidity through making valve upper portion 11 is less relatively, makes valve upper portion 11 softer, and the rigidity of leaflet suspension portion 12 is great relatively, and is harder for valve upper portion 11, at the in-process that will intervene the valve implantation human body, can intervene the valve and draw from the atrium to the ventricle through conveying system, make softer valve upper portion 11 can fully laminate with human valve mouth, and carry out natural shaping according to human valve mouth shape, thereby can effectively reduce the emergence of backflowing and accelerate postoperative endothelialization, make intervene the valve can be at internal steady operation.
It will be appreciated that the human aorta is spaced relatively close to the mitral valve, with only one curtain, which is pushed by blood to one side of the mitral valve during the period when the aortic valve is open and the mitral valve is closed, to provide a more open aortic inflow channel to reduce resistance to blood flow. The interventional mitral valve stent provided by the embodiment enables the valve upper part 11 to have relatively strong elastic deformation capability by enabling the valve upper part 11 to have relatively small rigidity, so that the curtain can be more easily pushed to one side of the interventional valve by blood during the closing of the mitral valve and the opening of the aorta, and the stability of aortic hemodynamics is ensured.
In addition, the leaflet generally needs to be fixed on the leaflet suspension portion 12 to realize the connection of the leaflet with the leaflet frame, and if the leaflet suspension portion 12 has the same lower rigidity as the upper portion 11 of the valve, the leaflet suspension portion 12 is made to be softer, which is not favorable for the connection and fixation of the leaflet, and is also not favorable for the effective closing of the access valve of the leaflet in the working process.
Therefore, in the present embodiment, the leaflet suspension portion 12 has a greater rigidity with respect to the upper portion 11 of the valve, so that the leaflet suspension portion 12 is less likely to deform, thereby improving the reliability of fixation of the leaflet, ensuring the normal operation of the intervention valve, and extending the service life.
As shown in fig. 1, the valve upper portion 11 and the valve leaflet hanging portion 12 are both a mesh structure, a plurality of mesh holes 14 are provided in the mesh structure, and a connecting beam 13 is formed between two adjacent mesh holes 14.
It should be noted that to facilitate the deformation of the interventional mitral valve stent, the shape of the mesh 14 may be diamond-shaped. Wherein, the valve support can be a memory alloy plate material, such as nickel titanium alloy.
Wherein, the flap upper portion 11 and the flap hanging portion 12 may be integrally formed.
As a specific implementation, the total cross-sectional area of the connecting beams of the flap upper portion 11 is smaller than the total cross-sectional area of the connecting beams of the leaflet suspension portion 12.
In a natural state, the whole valve stent 1 has a hollow cylindrical structure, and the cross section of the hollow cylindrical structure can be D-shaped, oval or circular.
Thus, by making the total cross-sectional area of the bridge of the flap upper portion 11 smaller than the total cross-sectional area of the bridge of the leaflet suspension portion 12, the amount of material used for the bridge 13 in the flap upper portion 11 can be made relatively small, so that the stiffness of the flap upper portion 11 can be made relatively low, while the softness is relatively enhanced. In contrast, the material of the connection beam 13 in the leaflet suspension portion 12 is used in a relatively large amount, so that the stiffness of the leaflet suspension portion 12 can be made relatively high and the resistance to deformation can be made relatively strong.
As a specific implementation, the ratio between the total cross-sectional area of the connecting beams of the leaflet upper portion 11 and the total cross-sectional area of the connecting beams of the leaflet hanging portion 12 may range from 0.3 to 0.7. In this embodiment, the ratio may preferably be 0.4, 0.5 or 0.6.
In a specific embodiment, as shown in fig. 1 to 3, the thickness b2 of the connection beam 13 of the leaflet suspension 12 is not less than the radial thickness b1 of the connection beam 13 of the upper leaflet 11.
Wherein, the thickness b2 of all the connection beams 13 in the leaflet suspension portion 12 may be greater than the thickness b1 of all the connection beams 13 in the leaflet upper portion 11; it is also possible that the thickness b2 of a part of the connection beams 13 in the leaflet suspension 12 is greater than the thickness b1 of the connection beams 13 in the upper leaflet 11, and the thickness b2 of another part of the connection beams 13 in the leaflet suspension 12 is equal to the thickness b1 of the connection beams 13 in the upper leaflet 11. Therefore, the material consumption of the connection beam 13 in the leaflet suspending portion 12 can be made relatively large, and the stiffness of the leaflet suspending portion 12 is made relatively high, and the resistance to deformation is made relatively strong. At the same time, the material of the connecting beam 13 in the flap upper part 11 can be used in a relatively small amount, so that the stiffness of the flap upper part 11 can be made relatively low and the softness relatively increased.
As shown in fig. 2 and 3, in the present embodiment, the width and the number of the connecting beams 13 in the valve upper portion 11 and the leaflet suspension portion 12 may be the same, and the total cross-sectional area of the connecting beams is changed by changing the thickness of the connecting beams 13 in the valve upper portion 11 and the leaflet suspension portion 12, and the rigidity of the valve upper portion 11 and the leaflet suspension portion 12 is changed.
Of course, while the thickness of the connecting beams 13 in the valve upper portion 11 and the leaflet suspending portion 12 is changed, the width and the number of the connecting beams 13 in the valve upper portion 11 and the leaflet suspending portion 12 may also be changed as appropriate, specifically, the total cross-sectional area of the connecting beams in the valve upper portion 11 is smaller than the total cross-sectional area of the connecting beams in the leaflet suspending portion 12, and the requirements for the rigidity of the two are taken as the criteria, which is not limited in this embodiment.
In another specific embodiment, as shown in fig. 4 and 5, the width c2 of the connecting beam 13 of the leaflet suspension 12 is not less than the width c1 of the connecting beam 13 of the upper leaflet 11.
Wherein, in the expanded state of the valve stent 1, the width of the connecting beam 13 can be the distance between two adjacent mesh openings 14 separated by one connecting beam 13.
Specifically, it may be that the width c2 of all the connection beams 13 in the leaflet suspension portion 12 is greater than the width c1 of all the connection beams 13 in the leaflet upper portion 11, as shown in fig. 4; it is also possible that the width c2 of a part of the connecting beams 13 in the leaflet suspension 12 is greater than the width c1 of the connecting beams 13 in the upper leaflet 11, and the width c2 of another part of the connecting beams 13 in the leaflet suspension 12 is equal to the width c1 of the connecting beams 13 in the upper leaflet 11. Therefore, the material usage of the connection beam in the leaflet suspension portion 12 can be relatively large, and further, the stiffness of the leaflet suspension portion 12 is relatively high and the ability to resist deformation is relatively strong. At the same time, the material of the connecting beam 13 in the flap upper part 11 can be used in a relatively small amount, so that the stiffness of the flap upper part 11 can be made relatively low and the softness relatively increased.
As shown in fig. 4 and 5, in the present embodiment, the thickness and the number of the connecting beams 13 in the valve upper portion 11 and the leaflet suspension portion 12 may be the same, and the total cross-sectional area of the connecting beams is changed by changing only the width of the connecting beams 13 in the valve upper portion 11 and the leaflet suspension portion 12, thereby changing the rigidity of the valve upper portion 11 and the leaflet suspension portion 12.
Of course, while the width of the connecting beams 13 in the valve upper portion 11 and the leaflet suspending portion 12 is changed, the thickness and the number of the connecting beams 13 in the valve upper portion 11 and the leaflet suspending portion 12 may also be changed as appropriate, specifically, the total cross-sectional area of the connecting beams in the valve upper portion 11 is smaller than the total cross-sectional area of the connecting beams in the leaflet suspending portion 12, and the requirements for the rigidity of the two are taken as the criteria, which is not limited in this embodiment.
In yet another specific embodiment, as shown in fig. 6 and 7, the number of the connection beams 13 of the leaflet suspension portion 12 is not less than the number of the connection beams 13 of the upper leaflet portion 11.
Wherein, as shown in fig. 6, when there are fewer connecting beams 13 in the flap upper portion 11, the number of mesh openings 14 formed between the connecting beams 13 is also smaller, and the area of the mesh openings 14 is increased, resulting in that the number of connecting beams 13 is also smaller, i.e., the amount of material of the connecting beams 13 is relatively reduced, and the rigidity is lowered; when the number of the connecting beams 13 is large, the arrangement among the connecting beams 13 is dense, the number of the connecting beams 13 is increased, that is, the amount of the material of the connecting beams 13 is relatively increased, and the rigidity is increased.
Specifically, it may be that the number of all the connection beams 13 in the leaflet suspension portion 12 is greater than the number of all the connection beams 13 in the leaflet upper portion 11, as shown in fig. 6; it is also possible that the number of a part of the connection beams 13 in the leaflet suspension 12 is greater than the number of the connection beams 13 in the upper leaflet portion 11, and the number of another part of the connection beams 13 in the leaflet suspension 12 is equal to the number of the connection beams 13 in the upper leaflet portion 11. Therefore, the material consumption of the connection beam 13 in the leaflet suspending portion 12 can be made relatively large, and the stiffness of the leaflet suspending portion 12 is made relatively high, and the resistance to deformation is made relatively strong. At the same time, the material of the connecting beam 13 in the flap upper part 11 can be used in a relatively small amount, so that the stiffness of the flap upper part 11 can be made relatively low and the softness relatively increased.
Note that, as shown in fig. 6 and 7, in the present embodiment, the thickness and the width of the connecting beams 13 in the flap upper portion 11 and the leaflet suspension portion 12 may be the same, and the change of the total cross-sectional area of the connecting beams in both the flap upper portion 11 and the leaflet suspension portion 12, and thus the rigidity of the flap upper portion 11 and the leaflet suspension portion 12, is realized only by changing the number of the connecting beams 13 in both the flap upper portion 11 and the leaflet suspension portion 12.
Of course, while the number of the connecting beams 13 in the valve upper portion 11 and the leaflet suspending portion 12 is changed, the thickness and the width of the connecting beams 13 in the valve upper portion 11 and the leaflet suspending portion 12 may also be changed as appropriate, and the present embodiment is not limited to this, specifically, the total cross-sectional area of the connecting beams in the valve upper portion 11 is smaller than the total cross-sectional area of the connecting beams in the leaflet suspending portion 12, and the requirements for the rigidity of the two are taken as the criteria.
In a more preferred embodiment, when the rigidity of the valve upper portion 11 and the leaflet hanging portion 12 is changed by changing the thickness, width or number of the connecting beams 13, the thickness or width of the connecting beams 13 can be gradually changed and transited between the valve upper portion 11 and the leaflet hanging portion 12, so that the total cross-sectional area of the connecting beams of the valve upper portion 11 and the total cross-sectional area of the connecting beams of the leaflet hanging portion 12 are gradually transited without forming a strict boundary line to the total cross-sectional area, and thus, the acting force from blood can be uniformly transited on the valve support 1 and the leaflets, and the stable operation of the intervention valve in a human body is ensured.
As a specific implementation, the height h of the flap upper portion 11 may be 3-8mm, as shown in FIG. 2. Therefore, the valve upper part 11 can be effectively fitted with the human mitral valve orifice, the perivalvular leakage is reduced, and endothelialization is carried out as soon as possible, so that the interventional valve and the human body are integrated into a whole. The height h of the flap upper part 11 may be 4mm, 5mm, 6mm, or 7 mm.
It should be noted that the interventional mitral valve stent provided by the embodiments of the present application can also be applied to other valve sites.
The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims (7)
1. An interventional mitral valve stent comprising an upper valve portion (11) and a leaflet suspension portion (12), the upper valve portion (11) being connected above the leaflet suspension portion (12), the upper valve portion (11) having a stiffness less than the stiffness of the leaflet suspension portion (12) to reduce the incidence of regurgitation and accelerate post-operative endothelialization;
the valve upper part (11) and the valve leaf hanging part (12) are both of a net structure, a plurality of net holes (14) are formed in the net structure, and a connecting beam (13) is formed between every two adjacent net holes (14);
the total cross-sectional area of the connecting beams of the leaflet upper portion (11) is smaller than the total cross-sectional area of the connecting beams of the leaflet suspension portion (12).
2. The interventional mitral valve stent according to claim 1, wherein a ratio between a total cross-sectional area of the connecting beams of the valve upper portion (11) and a total cross-sectional area of the connecting beams of the leaflet suspension (12) ranges from 0.3 to 0.7.
3. The interventional mitral valve stent of claim 1, wherein a thickness (b2) of the connection beams (13) of the leaflet suspension (12) is not less than a thickness (b1) of the connection beams (13) of the valve upper portion (11).
4. The interventional mitral valve stent of claim 3, wherein a width (c2) of the connection beams (13) of the leaflet suspension (12) is not less than a width (c1) of the connection beams (13) of the valve upper portion (11).
5. The interventional mitral valve stent of claim 4, wherein a width or thickness of the bridge of the upper valve portion and a width or thickness of the bridge of the leaflet suspension gradually transition between the upper valve portion and the leaflet suspension.
6. The interventional mitral valve stent according to claim 1, wherein the number of connecting beams (13) of the leaflet suspension (12) is not less than the number of connecting beams (13) of the valve upper part (11).
7. The interventional mitral valve stent of any one of claims 1-5, wherein the height (h) of the valve upper part (11) is 3-8 mm.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011086959.3A CN112402058A (en) | 2020-10-12 | 2020-10-12 | Intervention mitral valve stent |
| PCT/CN2021/129991 WO2022078525A1 (en) | 2020-10-12 | 2021-11-11 | Interventional mitral valve stent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011086959.3A CN112402058A (en) | 2020-10-12 | 2020-10-12 | Intervention mitral valve stent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112402058A true CN112402058A (en) | 2021-02-26 |
Family
ID=74854009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011086959.3A Pending CN112402058A (en) | 2020-10-12 | 2020-10-12 | Intervention mitral valve stent |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN112402058A (en) |
| WO (1) | WO2022078525A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022078525A1 (en) * | 2020-10-12 | 2022-04-21 | 金仕生物科技（常熟）有限公司 | Interventional mitral valve stent |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2022078525A1 (en) | 2022-04-21 |
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